GO Annotations

A GO annotation is a statement about the function of a particular gene. Each GO annotation consists of an association between a gene and a GO term. Together, these statements comprise a “snapshot” of current biological knowledge. Different pieces of knowledge regarding gene function may be established to different degrees, which is why each GO annotation always refers to the evidence upon which it is based. Evidence is presented in the form of a GO ‘evidence code’ and either a published reference or description of the methodology used to create the annotation.


The work of the Gene Ontology Consortium (GOC) is only possible through collaborations among the members of a very active research community. Below are links to the Consortium's own projects and those conducted in collaboration with other research groups.

Contact GO

Contact the GO Help Desk with questions, comments, or feedback.

For questions, first check our Frequently Asked Questions, as your query may have already been answered.

The GOC also supports several mailing lists to foster discussion within the GO community. Subscribe to one or more of these mailing lists to follow general developments, discussions within the GOC, or to post a message to the GO community.

Reviewing GO annotations for a gene or protein

To start, check if there are existing annotations to the gene or protein of interest: open a Gene Ontology browser (e.g. AmiGO, QuickGO) and search for the gene or gene protein record of interest by entering it in the 'Search' field, then browse associated annotations and follow links to see the full list of annotations:

Reviewing GO annotations associated with a scientific article

To start, check if there are existing annotations to the paper:  Open a Gene Ontology browser, (e.g. AmiGO, QuickGO) and enter a PubMed identifier (PMID) for the paper of interest in the 'Search' field.

SynGO - Synapse Biology


The Synapse Gene Ontology and Annotation Initiative (SynGO) aims to:
  • Improve the Gene Ontology to accurately describe cellular components (CC) and biological processes (BP) important for synapse biology
  • Provide expert curated annotations of pre- and postsynaptic genes using the improved Gene Ontology classes

SynGO is funded by the Stanley Center for Psychiatric Research at the Broad Institute