Domain specialist

SynGO - Synapse Biology


The Synapse Gene Ontology and Annotation Initiative (SynGO) aims to:
  • Improve the Gene Ontology to accurately describe cellular components (CC) and biological processes (BP) important for synapse biology
  • Provide expert curated annotations of pre- and postsynaptic genes using the improved Gene Ontology classes

SynGO is funded by the Stanley Center for Psychiatric Research at the Broad Institute

Detection and Response To Stimulus

Terms and Structure

The response of a cell or an organism to a stimulus is all the processes that occur as a result of the stimulus occurring within or outside the cell or organism. Detection of the stimulus, the process in which a stimulus is received by a cell and converted into a molecular signal, is thus a class of stimulus response. The general structure of this node is as follows:

  • response to stimulus
    • [i] detection of stimulus
      • [i] detection of [stimulus type] stimulus


The set of standard terms below can be applied to each developing structure in each species covered in the ontology. However it is generally not practical to implement every term for every structure, since this would lead to a massive proliferation of terms. Where one term e.g. x development, is present, the rest of the terms for the development of x are considered to be implied, without having actually been implemented. Further terms are generally only implemented when they are required for annotation.

The Cell Cycle

The representation of the cell cycle in GO is split into two sections: the physical processes that occur and the temporal stages—prophase, anaphase and so on—used to describe sets of events. This method of representation is used to prevent true path problems when organisms differ from the "canonical" (usually S. cerevisiae) cell cycle.

Terms and Structure

The cell cycle node sits under cellular process ; GO:0007049 and is split into types of cell cycle (meiotic or mitotic) and stages (M phase, S phase, etc.), plus a regulation term.

  • cell cycle