format-version: 1.2
date: 01:07:2008 10:08
saved-by: midori
auto-generated-by: OBO-Edit 1.101
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
remark: cvs version: $Revision: 1.1 $

[Term]
id: GO:0001509
name: legumain activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34]
synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "citvac" RELATED [EC:3.4.22.34]
synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34]
synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
xref: EC:3.4.22.34
xref: MetaCyc:3.4.22.34-RXN
is_obsolete: true

[Term]
id: GO:0003802
name: coagulation factor VIIa activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253]
synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21]
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21]
xref: EC:3.4.21.21
xref: MetaCyc:3.4.21.21-RXN
xref: Reactome:11520
is_obsolete: true

[Term]
id: GO:0003803
name: coagulation factor IXa activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22]
synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22]
synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22]
synonym: "activated christmas factor" RELATED [EC:3.4.21.22]
synonym: "autoprothrombin II" RELATED [EC:3.4.21.22]
synonym: "blood coagulation factor IX activity" EXACT []
synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22]
synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22]
synonym: "Christmas factor activity" EXACT [EC:3.4.21.22]
xref: EC:3.4.21.22
xref: MetaCyc:3.4.21.22-RXN
xref: Reactome:11522
is_obsolete: true

[Term]
id: GO:0003804
name: coagulation factor Xa activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023]
synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6]
synonym: "activated factor X" RELATED [EC:3.4.21.6]
synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6]
synonym: "autoprothrombin C" RELATED [EC:3.4.21.6]
synonym: "blood coagulation factor X activity" EXACT []
synonym: "factor Xa" RELATED [EC:3.4.21.6]
synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6]
synonym: "prothrombase activity" EXACT [EC:3.4.21.6]
synonym: "prothrombinase activity" EXACT [EC:3.4.21.6]
synonym: "Stuart factor" RELATED [EC:3.4.21.6]
synonym: "Stuart factor activity" EXACT [EC:3.4.21.6]
synonym: "thrombokinase activity" EXACT [EC:3.4.21.6]
synonym: "thromboplastin" RELATED [EC:3.4.21.6]
xref: EC:3.4.21.6
xref: MetaCyc:3.4.21.6-RXN
xref: Reactome:11523
is_obsolete: true

[Term]
id: GO:0003805
name: coagulation factor XIa activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27]
synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27]
synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27]
synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27]
synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27]
xref: EC:3.4.21.27
xref: MetaCyc:3.4.21.27-RXN
xref: Reactome:11530
is_obsolete: true

[Term]
id: GO:0003806
name: coagulation factor XIIa activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38]
synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38]
synonym: "blood coagulation factor XII activity" EXACT []
synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38]
synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38]
synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38]
synonym: "hageman factor activity" EXACT [EC:3.4.21.38]
synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38]
synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38]
synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38]
synonym: "prealbumin activator" RELATED [EC:3.4.21.38]
synonym: "prekallikrein activator" RELATED [EC:3.4.21.38]
xref: EC:3.4.21.38
xref: MetaCyc:3.4.21.38-RXN
xref: Reactome:11532
is_obsolete: true

[Term]
id: GO:0003807
name: plasma kallikrein activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34]
synonym: "bradykininogenase" BROAD [EC:3.4.21.34]
synonym: "callicrein" RELATED [EC:3.4.21.34]
synonym: "depot-padutin" RELATED [EC:3.4.21.34]
synonym: "dilminal D" RELATED [EC:3.4.21.34]
synonym: "glumorin" RELATED [EC:3.4.21.34]
synonym: "kallidinogenase" BROAD [EC:3.4.21.34]
synonym: "kallikrein" RELATED [EC:3.4.21.34]
synonym: "kallikrein I" RELATED [EC:3.4.21.34]
synonym: "kallikrein II" RELATED [EC:3.4.21.34]
synonym: "kininogenase" BROAD [EC:3.4.21.34]
synonym: "kininogenin activity" RELATED [EC:3.4.21.34]
synonym: "onokrein P" RELATED [EC:3.4.21.34]
synonym: "padreatin" RELATED [EC:3.4.21.34]
synonym: "padutin" RELATED [EC:3.4.21.34]
synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34]
synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.34]
synonym: "urokallikrein" RELATED [EC:3.4.21.34]
xref: EC:3.4.21.34
xref: MetaCyc:3.4.21.34-RXN
xref: Reactome:11535
is_obsolete: true

[Term]
id: GO:0003808
name: protein C (activated) activity
namespace: molecular_function
def: "Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69]
synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69]
synonym: "activated protein C" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69]
synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69]
synonym: "GSAPC" RELATED [EC:3.4.21.69]
synonym: "protein Ca" RELATED [EC:3.4.21.69]
xref: EC:3.4.21.69
xref: MetaCyc:3.4.21.69-RXN
xref: Reactome:11537
is_obsolete: true

[Term]
id: GO:0003809
name: thrombin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5]
synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5]
synonym: "beta-thrombin" RELATED [EC:3.4.21.5]
synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5]
synonym: "E thrombin" RELATED [EC:3.4.21.5]
synonym: "factor IIa" RELATED [EC:3.4.21.5]
synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5]
synonym: "gamma-thrombin" RELATED [EC:3.4.21.5]
synonym: "thrombase activity" EXACT [EC:3.4.21.5]
synonym: "thrombin-C" RELATED [EC:3.4.21.5]
synonym: "thrombofort" RELATED [EC:3.4.21.5]
synonym: "topical" RELATED [EC:3.4.21.5]
synonym: "tropostasin" RELATED [EC:3.4.21.5]
xref: EC:3.4.21.5
xref: MetaCyc:3.4.21.5-RXN
xref: Reactome:11540
is_obsolete: true

[Term]
id: GO:0003812
name: alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47]
synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47]
synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47]
synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47]
synonym: "C3 convertase activity" BROAD [EC:3.4.21.47]
synonym: "C3 proactivator" RELATED [EC:3.4.21.47]
synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.47]
synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47]
synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47]
synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47]
synonym: "complement factor B activity" EXACT [EC:3.4.21.47]
synonym: "CVF,Bb" RELATED [EC:3.4.21.47]
synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47]
synonym: "heat-labile factor" RELATED [EC:3.4.21.47]
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" EXACT [EC:3.4.21.47]
xref: EC:3.4.21.47
xref: MetaCyc:3.4.21.47-RXN
xref: Reactome:11550
is_obsolete: true

[Term]
id: GO:0003813
name: classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43]
synonym: "C3 convertase activity" BROAD [EC:3.4.21.43]
synonym: "C42" RELATED [EC:3.4.21.43]
synonym: "C423" RELATED [EC:3.4.21.43]
synonym: "C4b,2a" RELATED [EC:3.4.21.43]
synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.43]
synonym: "complement C2 activity" BROAD [EC:3.4.21.43]
synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43]
synonym: "complement C42" RELATED [EC:3.4.21.43]
xref: EC:3.4.21.43
xref: MetaCyc:3.4.21.43-RXN
xref: Reactome:11551
is_obsolete: true

[Term]
id: GO:0003815
name: complement component C1r activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41]
synonym: "activated complement C1r" RELATED [EC:3.4.21.41]
synonym: "C1r esterase activity" EXACT [EC:3.4.21.41]
synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41]
xref: EC:3.4.21.41
xref: MetaCyc:3.4.21.41-RXN
xref: Reactome:11553
is_obsolete: true

[Term]
id: GO:0003816
name: complement component C1s activity
namespace: molecular_function
def: "Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42]
synonym: "activated complement C1s" RELATED [EC:3.4.21.42]
synonym: "C1 esterase activity" EXACT [EC:3.4.21.42]
synonym: "C1s esterase activity" EXACT [EC:3.4.21.42]
synonym: "complement C1s" RELATED [EC:3.4.21.42]
synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42]
xref: EC:3.4.21.42
xref: MetaCyc:3.4.21.42-RXN
is_obsolete: true

[Term]
id: GO:0003817
name: complement factor D activity
namespace: molecular_function
def: "Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46]
synonym: "adipsin" EXACT []
synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46]
synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46]
synonym: "factor D" RELATED [EC:3.4.21.46]
synonym: "factor D (complement)" RELATED [EC:3.4.21.46]
synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46]
xref: EC:3.4.21.46
xref: MetaCyc:3.4.21.46-RXN
xref: Reactome:11557
is_obsolete: true

[Term]
id: GO:0003818
name: complement factor I activity
namespace: molecular_function
def: "Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45]
synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45]
synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "C3bINA" RELATED [EC:3.4.21.45]
synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4bi" RELATED [EC:3.4.21.45]
synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45]
synonym: "factor I" RELATED [EC:3.4.21.45]
xref: EC:3.4.21.45
xref: MetaCyc:3.4.21.45-RXN
is_obsolete: true

[Term]
id: GO:0004178
name: leucyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1]
subset: gosubset_prok
synonym: "aminopeptidase II" RELATED [EC:3.4.11.1]
synonym: "cathepsin III" RELATED [EC:3.4.11.1]
synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1]
synonym: "FTBL proteins" RELATED [EC:3.4.11.1]
synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1]
synonym: "peptidase S activity" NARROW [EC:3.4.11.1]
synonym: "proteinates FTBL" RELATED [EC:3.4.11.1]
xref: EC:3.4.11.1
xref: MetaCyc:3.4.11.1-RXN
is_obsolete: true

[Term]
id: GO:0004179
name: membrane alanyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2]
subset: gosubset_prok
synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2]
synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2]
synonym: "CD13" RELATED [EC:3.4.11.2]
synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2]
synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2]
synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2]
synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "peptidase E activity" BROAD [EC:3.4.11.2]
synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2]
xref: EC:3.4.11.2
xref: MetaCyc:3.4.11.2-RXN
is_obsolete: true

[Term]
id: GO:0004182
name: carboxypeptidase A activity
namespace: molecular_function
alt_id: GO:0008731
def: "Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1]
subset: gosubset_prok
synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1]
synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1]
synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1]
xref: EC:3.4.17.1
xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
is_obsolete: true

[Term]
id: GO:0004183
name: carboxypeptidase E activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10]
synonym: "carboxypeptidase H activity" EXACT []
synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10]
synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10]
synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10]
xref: EC:3.4.17.10
xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
is_obsolete: true

[Term]
id: GO:0004184
name: lysine carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3]
synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3]
synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3]
synonym: "carboxypeptidase N activity" EXACT []
synonym: "CPase N" RELATED [EC:3.4.17.3]
synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3]
synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3]
synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3]
synonym: "kininase I activity" EXACT [EC:3.4.17.3]
synonym: "kininase Ia" RELATED [EC:3.4.17.3]
synonym: "lysine (arginine) carboxypeptidase activity" EXACT []
synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3]
synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3]
xref: EC:3.4.17.3
xref: MetaCyc:LYSINE(ARGININE)-CARBOXYPEPTIDASE-RXN
is_obsolete: true

[Term]
id: GO:0004186
name: carboxypeptidase C activity
namespace: molecular_function
def: "Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5]
synonym: "cathepsin A activity" NARROW [EC:3.4.16.5]
synonym: "deamidase" RELATED [EC:3.4.16.5]
synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5]
synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5]
synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "vacuolar carboxypeptidase Y" NARROW []
xref: EC:3.4.16.5
xref: MetaCyc:3.4.16.5-RXN
is_obsolete: true

[Term]
id: GO:0004187
name: carboxypeptidase D activity
namespace: molecular_function
def: "Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6]
synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6]
synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6]
synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6]
synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6]
synonym: "CPDW-II" RELATED [EC:3.4.16.6]
synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6]
synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6]
synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6]
xref: EC:3.4.16.6
xref: MetaCyc:3.4.16.6-RXN
is_obsolete: true

[Term]
id: GO:0004188
name: serine-type Pro-X carboxypeptidase activity
namespace: molecular_function
alt_id: GO:0008323
def: "Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2]
synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW []
synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "PCP" RELATED [EC:3.4.16.2]
synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2]
synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2]
xref: EC:3.4.16.2
xref: MetaCyc:3.4.16.2-RXN
is_obsolete: true

[Term]
id: GO:0004189
name: tubulinyl-Tyr carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17]
synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17]
synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "TTCPase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT []
synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
xref: EC:3.4.17.17
xref: MetaCyc:3.4.17.17-RXN
is_obsolete: true

[Term]
id: GO:0004191
name: barrierpepsin activity
namespace: molecular_function
def: "Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35]
synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35]
synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35]
synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35]
xref: EC:3.4.23.35
xref: MetaCyc:3.4.23.35-RXN
is_obsolete: true

[Term]
id: GO:0004192
name: cathepsin D activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]
xref: EC:3.4.23.5
xref: MetaCyc:3.4.23.5-RXN
is_obsolete: true

[Term]
id: GO:0004193
name: cathepsin E activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34]
synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "EMAP" RELATED [EC:3.4.23.34]
synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34]
synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34]
synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34]
synonym: "SMP" RELATED [EC:3.4.23.34]
xref: EC:3.4.23.34
xref: MetaCyc:3.4.23.34-RXN
is_obsolete: true

[Term]
id: GO:0004194
name: pepsin A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1]
synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1]
synonym: "fundus-pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1]
synonym: "P I" RELATED [EC:3.4.23.1]
synonym: "P II" RELATED [EC:3.4.23.1]
synonym: "pepsin activity" BROAD [EC:3.4.23.1]
synonym: "pepsin D" RELATED [EC:3.4.23.1]
synonym: "pepsin fortior" RELATED [EC:3.4.23.1]
synonym: "pepsin R" RELATED [EC:3.4.23.1]
xref: EC:3.4.23.1
xref: MetaCyc:3.4.23.1-RXN
is_obsolete: true

[Term]
id: GO:0004195
name: renin activity
namespace: molecular_function
def: "Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15]
synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15]
synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15]
xref: EC:3.4.23.15
xref: MetaCyc:3.4.23.15-RXN
is_obsolete: true

[Term]
id: GO:0004196
name: saccharopepsin activity
namespace: molecular_function
def: "Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25]
synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "PRA" RELATED [EC:3.4.23.25]
synonym: "proteinase A" RELATED [EC:3.4.23.25]
synonym: "proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25]
synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25]
synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25]
synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25]
synonym: "yeast proteinase A" RELATED [EC:3.4.23.25]
xref: EC:3.4.23.25
xref: MetaCyc:3.4.23.25-RXN
is_obsolete: true

[Term]
id: GO:0004213
name: cathepsin B activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1]
synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1]
synonym: "cathepsin II" RELATED [EC:3.4.22.1]
xref: EC:3.4.22.1
xref: MetaCyc:3.4.22.1-RXN
is_obsolete: true

[Term]
id: GO:0004214
name: dipeptidyl-peptidase I activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1]
synonym: "cathepsin C activity" EXACT [EC:3.4.14.1]
synonym: "cathepsin J activity" EXACT [EC:3.4.14.1]
synonym: "DAP I" RELATED [EC:3.4.14.1]
synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1]
synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1]
synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1]
xref: EC:3.4.14.1
xref: MetaCyc:3.4.14.1-RXN
is_obsolete: true

[Term]
id: GO:0004215
name: cathepsin H activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16]
synonym: "aleurain activity" EXACT [EC:3.4.22.16]
synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin Ba" RELATED [EC:3.4.22.16]
synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16]
synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16]
xref: EC:3.4.22.16
xref: MetaCyc:3.4.22.16-RXN
is_obsolete: true

[Term]
id: GO:0004216
name: cathepsin K activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38]
synonym: "cathepsin O activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin X activity" EXACT [EC:3.4.22.38]
xref: EC:3.4.22.38
xref: MetaCyc:3.4.22.38-RXN
is_obsolete: true

[Term]
id: GO:0004217
name: cathepsin L activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15]
synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15]
xref: EC:3.4.22.15
xref: MetaCyc:3.4.22.15-RXN
is_obsolete: true

[Term]
id: GO:0004218
name: cathepsin S activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]
xref: EC:3.4.22.27
xref: MetaCyc:3.4.22.27-RXN
is_obsolete: true

[Term]
id: GO:0004219
name: pyroglutamyl-peptidase I activity
namespace: molecular_function
def: "Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3]
comment: Note that pyroglutamic acid has sometimes been referred to as 5-oxoproline.
subset: gosubset_prok
synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrase activity" EXACT [EC:3.4.19.3]
synonym: "PYRase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3]
xref: EC:3.4.19.3
xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN
is_obsolete: true

[Term]
id: GO:0004226
name: Gly-X carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4]
subset: gosubset_prok
synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4]
synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4]
synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "peptidase alpha" RELATED [EC:3.4.17.4]
synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4]
xref: EC:3.4.17.4
xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
is_obsolete: true

[Term]
id: GO:0004228
name: gelatinase A activity
namespace: molecular_function
def: "Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24]
synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24]
synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24]
synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24]
synonym: "collagenase IV" RELATED [EC:3.4.24.24]
synonym: "collagenase type IV" RELATED [EC:3.4.24.24]
synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24]
synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24]
synonym: "MMP 2" RELATED [EC:3.4.24.24]
synonym: "MMP-2" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24]
synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24]
synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24]
xref: EC:3.4.24.24
xref: MetaCyc:3.4.24.24-RXN
is_obsolete: true

[Term]
id: GO:0004229
name: gelatinase B activity
namespace: molecular_function
def: "Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35]
synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35]
synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35]
synonym: "collagenase IV" RELATED [EC:3.4.24.35]
synonym: "collagenase type IV" RELATED [EC:3.4.24.35]
synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35]
synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35]
synonym: "MMP 9" RELATED [EC:3.4.24.35]
synonym: "MMP-9" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35]
synonym: "type V collagenase activity" EXACT [EC:3.4.24.35]
xref: EC:3.4.24.35
xref: MetaCyc:3.4.24.35-RXN
is_obsolete: true

[Term]
id: GO:0004230
name: glutamyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7]
subset: gosubset_prok
synonym: "aminopeptidase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A2" RELATED [EC:3.4.11.7]
synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7]
synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7]
synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7]
xref: EC:3.4.11.7
xref: MetaCyc:3.4.11.7-RXN
is_obsolete: true

[Term]
id: GO:0004231
name: insulysin activity
namespace: molecular_function
def: "Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56]
subset: gosubset_prok
synonym: "IDE" RELATED [EC:3.4.24.56]
synonym: "insulin protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56]
synonym: "insulinase activity" EXACT [EC:3.4.24.56]
synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56]
xref: EC:3.4.24.56
xref: MetaCyc:3.4.24.56-RXN
xref: Reactome:9609
is_obsolete: true

[Term]
id: GO:0004232
name: interstitial collagenase activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7]
synonym: "matrix metalloproteinase 1" EXACT []
synonym: "MMP-1" EXACT []
synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7]
xref: EC:3.4.24.7
xref: MetaCyc:3.4.24.7-RXN
is_obsolete: true

[Term]
id: GO:0004234
name: macrophage elastase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65]
synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65]
synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65]
synonym: "metalloelastase activity" EXACT [EC:3.4.24.65]
synonym: "metalloesterase activity" EXACT []
synonym: "MMP-12" EXACT []
xref: EC:3.4.24.65
xref: MetaCyc:3.4.24.65-RXN
is_obsolete: true

[Term]
id: GO:0004235
name: matrilysin activity
namespace: molecular_function
def: "Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23]
synonym: "matrin activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23]
synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23]
synonym: "MMP" RELATED [EC:3.4.24.23]
synonym: "MMP 7" RELATED [EC:3.4.24.23]
synonym: "MMP-7" EXACT []
synonym: "PUMP" RELATED [EC:3.4.24.23]
synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23]
synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23]
synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23]
synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23]
synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23]
xref: EC:3.4.24.23
xref: MetaCyc:3.4.24.23-RXN
is_obsolete: true

[Term]
id: GO:0004237
name: membrane dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19]
subset: gosubset_prok
synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19]
synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19]
synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19]
synonym: "DPH I activity" NARROW [EC:3.4.13.19]
synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "MDP" RELATED [EC:3.4.13.19]
synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19]
synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19]
xref: EC:3.4.13.19
xref: MetaCyc:3.4.13.19-RXN
is_obsolete: true

[Term]
id: GO:0004238
name: meprin A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18]
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18]
synonym: "meprin" RELATED [EC:3.4.24.18]
synonym: "meprin-a" RELATED [EC:3.4.24.18]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PPH" RELATED [EC:3.4.24.18]
xref: EC:3.4.24.18
xref: MetaCyc:3.4.24.18-RXN
is_obsolete: true

[Term]
id: GO:0004239
name: methionyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18]
subset: gosubset_prok
synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "MAP" RELATED [EC:3.4.11.18]
synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "peptidase M activity" EXACT [EC:3.4.11.18]
xref: EC:3.4.11.18
xref: MetaCyc:3.4.11.18-RXN
is_obsolete: true

[Term]
id: GO:0004240
name: mitochondrial processing peptidase activity
namespace: molecular_function
def: "Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64]
synonym: "alpha-mitochondrial processing peptidase" NARROW []
synonym: "beta-mitochondrial processing peptidase" NARROW []
synonym: "matrix peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64]
synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64]
synonym: "MPP" EXACT []
synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64]
synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64]
xref: EC:3.4.24.64
xref: MetaCyc:3.4.24.64-RXN
is_obsolete: true

[Term]
id: GO:0004243
name: mitochondrial intermediate peptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59]
synonym: "MIP" BROAD []
synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59]
xref: EC:3.4.24.59
xref: MetaCyc:3.4.24.59-RXN
is_obsolete: true

[Term]
id: GO:0004244
name: mitochondrial inner membrane peptidase activity
namespace: molecular_function
def: "Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769]
synonym: "IMP" BROAD []
xref: EC:3.4.99.-
is_obsolete: true

[Term]
id: GO:0004245
name: neprilysin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11]
subset: gosubset_prok
synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA" RELATED [EC:3.4.24.11]
synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11]
synonym: "CALLA antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11]
synonym: "CD10" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11]
synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11]
synonym: "enkephalinase activity" EXACT [EC:3.4.24.11]
synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11]
synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11]
synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11]
synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11]
xref: EC:3.4.24.11
xref: MetaCyc:3.4.24.11-RXN
is_obsolete: true

[Term]
id: GO:0004246
name: peptidyl-dipeptidase A activity
namespace: molecular_function
def: "Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1]
subset: gosubset_prok
synonym: "ACE activity" BROAD []
synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1]
synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1]
synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1]
synonym: "DCP" RELATED [EC:3.4.15.1]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1]
synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1]
synonym: "kininase II activity" EXACT [EC:3.4.15.1]
synonym: "PDH" RELATED [EC:3.4.15.1]
synonym: "peptidase P activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1]
xref: EC:3.4.15.1
xref: MetaCyc:3.4.15.1-RXN
is_obsolete: true

[Term]
id: GO:0004247
name: saccharolysin activity
namespace: molecular_function
def: "Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37]
synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37]
synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37]
synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37]
synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37]
xref: EC:3.4.24.37
xref: MetaCyc:3.4.24.37-RXN
is_obsolete: true

[Term]
id: GO:0004248
name: stromelysin 1 activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17]
synonym: "collagen-activating protein" RELATED [EC:3.4.24.17]
synonym: "collagenase activating protein" RELATED [EC:3.4.24.17]
synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17]
synonym: "MMP-3" EXACT []
synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "procollagenase activator" RELATED [EC:3.4.24.17]
synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "stromelysin" RELATED [EC:3.4.24.17]
synonym: "transin activity" EXACT [EC:3.4.24.17]
xref: EC:3.4.24.17
xref: MetaCyc:3.4.24.17-RXN
is_obsolete: true

[Term]
id: GO:0004249
name: stromelysin 3 activity
namespace: molecular_function
synonym: "matrix metalloproteinase 11" EXACT []
synonym: "MMP-11" EXACT []
xref: EC:3.4.24.-
is_obsolete: true

[Term]
id: GO:0004250
name: aminopeptidase I activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22]
subset: gosubset_prok
synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22]
synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22]
synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22]
synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22]
synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22]
xref: EC:3.4.11.22
xref: MetaCyc:3.4.11.22-RXN
is_obsolete: true

[Term]
id: GO:0004251
name: X-Pro dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9]
subset: gosubset_prok
synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9]
synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "peptidase D" RELATED [EC:3.4.13.9]
synonym: "prolidase activity" EXACT [EC:3.4.13.9]
synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "Xaa-Pro dipeptidase activity" EXACT []
xref: EC:3.4.13.9
xref: MetaCyc:3.4.13.9-RXN
is_obsolete: true

[Term]
id: GO:0004253
name: gamma-renin activity
namespace: molecular_function
def: "Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54]
xref: EC:3.4.21.54
xref: MetaCyc:3.4.21.54-RXN
is_obsolete: true

[Term]
id: GO:0004254
name: acylaminoacyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1]
subset: gosubset_prok
synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1]
synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1]
xref: EC:3.4.19.1
xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
is_obsolete: true

[Term]
id: GO:0004261
name: cathepsin G activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20]
synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20]
synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20]
xref: EC:3.4.21.20
xref: MetaCyc:3.4.21.20-RXN
is_obsolete: true

[Term]
id: GO:0004262
name: cerevisin activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48]
synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48]
synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48]
synonym: "peptidase beta" RELATED [EC:3.4.21.48]
synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48]
synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48]
xref: EC:3.4.21.48
xref: MetaCyc:3.4.21.48-RXN
is_obsolete: true

[Term]
id: GO:0004263
name: chymotrypsin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alpha-chymar" RELATED [EC:3.4.21.1]
synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1]
synonym: "avazyme" RELATED [EC:3.4.21.1]
synonym: "chymar" RELATED [EC:3.4.21.1]
synonym: "chymotest" RELATED [EC:3.4.21.1]
synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1]
synonym: "enzeon" RELATED [EC:3.4.21.1]
synonym: "quimar" RELATED [EC:3.4.21.1]
synonym: "quimotrase activity" EXACT [EC:3.4.21.1]
xref: EC:3.4.21.1
xref: MetaCyc:3.4.21.1-RXN
is_obsolete: true

[Term]
id: GO:0004274
name: dipeptidyl-peptidase IV activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5]
subset: gosubset_prok
synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5]
synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5]
synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5]
synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "pep X" RELATED [EC:3.4.14.5]
synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5]
synonym: "X-PDAP" RELATED [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
xref: EC:3.4.14.5
xref: MetaCyc:3.4.14.5-RXN
is_obsolete: true

[Term]
id: GO:0004275
name: enteropeptidase activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9]
synonym: "enterokinase activity" RELATED [EC:3.4.21.9]
xref: EC:3.4.21.9
xref: MetaCyc:3.4.21.9-RXN
is_obsolete: true

[Term]
id: GO:0004276
name: furin activity
namespace: molecular_function
def: "Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75]
synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75]
synonym: "PACE" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75]
synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75]
synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75]
synonym: "SPC3" RELATED [EC:3.4.21.75]
xref: EC:3.4.21.75
xref: MetaCyc:3.4.21.75-RXN
xref: Reactome:9708
is_obsolete: true

[Term]
id: GO:0004277
name: granzyme A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78]
synonym: "CTLA3" RELATED [EC:3.4.21.78]
synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78]
synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78]
synonym: "HuTPS" RELATED [EC:3.4.21.78]
synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78]
synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78]
synonym: "TSP-1" RELATED [EC:3.4.21.78]
xref: EC:3.4.21.78
xref: MetaCyc:3.4.21.78-RXN
is_obsolete: true

[Term]
id: GO:0004278
name: granzyme B activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79]
synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79]
synonym: "CCPII" RELATED [EC:3.4.21.79]
synonym: "CTLA1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79]
synonym: "granzyme G" RELATED [EC:3.4.21.79]
synonym: "granzyme H" RELATED [EC:3.4.21.79]
xref: EC:3.4.21.79
xref: MetaCyc:3.4.21.79-RXN
xref: Reactome:9714
is_obsolete: true

[Term]
id: GO:0004281
name: pancreatic elastase II activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71]
synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71]
xref: EC:3.4.21.71
xref: MetaCyc:3.4.21.71-RXN
is_obsolete: true

[Term]
id: GO:0004283
name: plasmin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7]
synonym: "actase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7]
synonym: "serum tryptase activity" EXACT [EC:3.4.21.7]
synonym: "thrombolysin" RELATED [EC:3.4.21.7]
xref: EC:3.4.21.7
xref: MetaCyc:3.4.21.7-RXN
xref: Reactome:9727
is_obsolete: true

[Term]
id: GO:0004284
name: acrosin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10]
synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10]
synonym: "acrozonase activity" EXACT [EC:3.4.21.10]
synonym: "alpha-acrosin" RELATED [EC:3.4.21.10]
synonym: "beta-acrosin" RELATED [EC:3.4.21.10]
synonym: "psi-acrosin" RELATED [EC:3.4.21.10]
xref: EC:3.4.21.10
xref: MetaCyc:3.4.21.10-RXN
is_obsolete: true

[Term]
id: GO:0004285
name: proprotein convertase 1 activity
namespace: molecular_function
def: "Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93]
synonym: "NEC 1 activity" NARROW [EC:3.4.21.93]
synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93]
synonym: "PC1 activity" NARROW [EC:3.4.21.93]
synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93]
synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93]
xref: EC:3.4.21.93
xref: MetaCyc:3.4.21.93-RXN
is_obsolete: true

[Term]
id: GO:0004286
name: proprotein convertase 2 activity
namespace: molecular_function
def: "Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94]
synonym: "NEC 2 activity" NARROW [EC:3.4.21.94]
synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94]
synonym: "PC2 activity" NARROW [EC:3.4.21.94]
synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94]
xref: EC:3.4.21.94
xref: MetaCyc:3.4.21.94-RXN
is_obsolete: true

[Term]
id: GO:0004287
name: prolyl oligopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26]
subset: gosubset_prok
synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26]
synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26]
synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26]
xref: EC:3.4.21.26
xref: MetaCyc:3.4.21.26-RXN
is_obsolete: true

[Term]
id: GO:0004289
name: subtilase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:3.4.21.-
is_obsolete: true

[Term]
id: GO:0004290
name: kexin activity
namespace: molecular_function
def: "Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61]
synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61]
synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 protease" NARROW [EC:3.4.21.61]
synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61]
synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61]
synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61]
synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61]
synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61]
synonym: "protease KEX2" RELATED [EC:3.4.21.61]
synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61]
synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61]
synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61]
xref: EC:3.4.21.61
xref: MetaCyc:3.4.21.61-RXN
is_obsolete: true

[Term]
id: GO:0004291
name: subtilisin activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62]
subset: gosubset_prok
synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62]
synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62]
synonym: "alcalase activity" EXACT [EC:3.4.21.62]
synonym: "ALK-enzyme" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62]
synonym: "bioprase AL 15" RELATED [EC:3.4.21.62]
synonym: "bioprase APL 30" RELATED [EC:3.4.21.62]
synonym: "colistinase activity" EXACT [EC:3.4.21.62]
synonym: "esperase activity" EXACT [EC:3.4.21.62]
synonym: "genenase I" RELATED [EC:3.4.21.62]
synonym: "kazusase activity" EXACT [EC:3.4.21.62]
synonym: "maxatase activity" EXACT [EC:3.4.21.62]
synonym: "opticlean" RELATED [EC:3.4.21.62]
synonym: "orientase 10B" RELATED [EC:3.4.21.62]
synonym: "protease S" RELATED [EC:3.4.21.62]
synonym: "protease VIII" RELATED [EC:3.4.21.62]
synonym: "protease XXVII" RELATED [EC:3.4.21.62]
synonym: "protin A 3L" RELATED [EC:3.4.21.62]
synonym: "savinase 16.0L" RELATED [EC:3.4.21.62]
synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62]
synonym: "savinase 4.0T" RELATED [EC:3.4.21.62]
synonym: "savinase 8.0L" RELATED [EC:3.4.21.62]
synonym: "savinase activity" EXACT [EC:3.4.21.62]
synonym: "SP 266" RELATED [EC:3.4.21.62]
synonym: "subtilisin BL" RELATED [EC:3.4.21.62]
synonym: "subtilisin DY" RELATED [EC:3.4.21.62]
synonym: "subtilisin E" RELATED [EC:3.4.21.62]
synonym: "subtilisin GX" RELATED [EC:3.4.21.62]
synonym: "subtilisin J" RELATED [EC:3.4.21.62]
synonym: "subtilisin S41" RELATED [EC:3.4.21.62]
synonym: "subtilisin sendai" RELATED [EC:3.4.21.62]
synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62]
synonym: "superase activity" EXACT [EC:3.4.21.62]
synonym: "thermoase" BROAD [EC:3.4.21.62]
synonym: "thermoase PC 10" RELATED [EC:3.4.21.62]
xref: EC:3.4.21.62
xref: MetaCyc:3.4.21.62-RXN
is_obsolete: true

[Term]
id: GO:0004293
name: tissue kallikrein activity
namespace: molecular_function
alt_id: GO:0004279
def: "Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35]
synonym: "bradykininogenase" BROAD [EC:3.4.21.35]
synonym: "callicrein" RELATED [EC:3.4.21.35]
synonym: "depot-padutin" RELATED [EC:3.4.21.35]
synonym: "dilminal D" RELATED [EC:3.4.21.35]
synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35]
synonym: "glumorin" RELATED [EC:3.4.21.35]
synonym: "kallidinogenase" BROAD [EC:3.4.21.35]
synonym: "kallikrein" RELATED [EC:3.4.21.35]
synonym: "kidney kallikrein" RELATED [EC:3.4.21.35]
synonym: "kininogenase" BROAD [EC:3.4.21.35]
synonym: "kininogenin activity" RELATED [EC:3.4.21.35]
synonym: "onokrein P" RELATED [EC:3.4.21.35]
synonym: "padreatin" RELATED [EC:3.4.21.35]
synonym: "padutin" RELATED [EC:3.4.21.35]
synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35]
synonym: "salivary kallikrein" RELATED [EC:3.4.21.35]
synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35]
synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urokallikrein" RELATED [EC:3.4.21.35]
xref: EC:3.4.21.35
xref: MetaCyc:3.4.21.35-RXN
is_obsolete: true

[Term]
id: GO:0004294
name: tripeptidyl-peptidase II activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10]
synonym: "TPP" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10]
xref: EC:3.4.14.10
xref: MetaCyc:3.4.14.10-RXN
is_obsolete: true

[Term]
id: GO:0004295
name: trypsin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4]
subset: gosubset_prok
synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "cocoonase activity" EXACT [EC:3.4.21.4]
synonym: "parenzyme" RELATED [EC:3.4.21.4]
synonym: "parenzymol" RELATED [EC:3.4.21.4]
synonym: "pseudotrypsin" RELATED [EC:3.4.21.4]
synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4]
synonym: "tripcellim" RELATED [EC:3.4.21.4]
synonym: "tryptar" RELATED [EC:3.4.21.4]
synonym: "trypure" RELATED [EC:3.4.21.4]
xref: EC:3.4.21.4
xref: MetaCyc:3.4.21.4-RXN
is_obsolete: true

[Term]
id: GO:0008125
name: pancreatic elastase I activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36]
synonym: "elaszym" RELATED [EC:3.4.21.36]
synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36]
synonym: "serine elastase" BROAD [EC:3.4.21.36]
xref: EC:3.4.21.36
xref: MetaCyc:3.4.21.36-RXN
is_obsolete: true

[Term]
id: GO:0008129
name: actinidain activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14]
synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14]
synonym: "actinidin activity" EXACT [EC:3.4.22.14]
synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14]
xref: EC:3.4.22.14
xref: MetaCyc:3.4.22.14-RXN
is_obsolete: true

[Term]
id: GO:0008130
name: neutrophil collagenase activity
namespace: molecular_function
def: "Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34]
synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34]
synonym: "MMP-8" EXACT []
synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34]
xref: EC:3.4.24.34
xref: MetaCyc:3.4.24.34-RXN
is_obsolete: true

[Term]
id: GO:0008132
name: pancreatic elastase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71]
xref: EC:3.4.21.-
is_obsolete: true

[Term]
id: GO:0008133
name: collagenase activity
namespace: molecular_function
xref: EC:3.4.24.-
is_obsolete: true

[Term]
id: GO:0008243
name: plasminogen activator activity
namespace: molecular_function
alt_id: GO:0004296
alt_id: GO:0004297
def: "Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73]
subset: gosubset_prok
synonym: "abbokinase activity" EXACT [EC:3.4.21.68]
synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68]
synonym: "t-PA" RELATED [EC:3.4.21.68]
synonym: "t-plasminogen activator activity" NARROW []
synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-]
synonym: "tPA activity" NARROW [EC:3.4.21.-]
synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "u-PA" RELATED [EC:3.4.21.68]
synonym: "u-plasminogen activator activity" NARROW []
synonym: "uPA" RELATED [EC:3.4.21.68]
synonym: "urinary esterase A" RELATED [EC:3.4.21.68]
synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "urokinase activity" RELATED [EC:3.4.21.-]
synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
xref: EC:3.4.21.-
xref: EC:3.4.21.68
xref: EC:3.4.21.73
xref: MetaCyc:3.4.21.68-RXN
xref: MetaCyc:3.4.21.73-RXN
xref: Reactome:9757
is_obsolete: true

[Term]
id: GO:0008319
name: prenyl protein specific endopeptidase activity
namespace: molecular_function
xref: EC:3.4.24.-
is_obsolete: true

[Term]
id: GO:0008322
name: Pro-X carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah]
is_obsolete: true

[Term]
id: GO:0008423
name: bleomycin hydrolase activity
namespace: molecular_function
def: "Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40]
subset: gosubset_prok
synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40]
xref: EC:3.4.22.40
xref: MetaCyc:3.4.22.40-RXN
is_obsolete: true

[Term]
id: GO:0008439
name: monophenol monooxygenase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai]
synonym: "prophenol oxidase activator" RELATED []
is_obsolete: true

[Term]
id: GO:0008450
name: O-sialoglycoprotein endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57]
subset: gosubset_prok
synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57]
synonym: "glycoprotease activity" RELATED [EC:3.4.24.57]
synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57]
xref: EC:3.4.24.57
xref: MetaCyc:3.4.24.57-RXN
is_obsolete: true

[Term]
id: GO:0008451
name: X-Pro aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9]
subset: gosubset_prok
synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9]
synonym: "aminopeptidase P" EXACT []
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9]
synonym: "Xaa-Pro aminopeptidase activity" EXACT []
xref: EC:3.4.11.9
xref: MetaCyc:3.4.11.9-RXN
is_obsolete: true

[Term]
id: GO:0008462
name: endopeptidase Clp activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92]
subset: gosubset_prok
synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92]
synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92]
synonym: "Clp protease" NARROW [EC:3.4.21.92]
synonym: "ClpP" RELATED [EC:3.4.21.92]
synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92]
synonym: "protease Ti activity" RELATED [EC:3.4.21.92]
xref: EC:3.4.21.92
xref: MetaCyc:3.4.21.92-RXN
is_obsolete: true

[Term]
id: GO:0008464
name: gamma-glutamyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9]
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9]
synonym: "conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folate conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9]
synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9]
synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9]
synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9]
synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9]
synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9]
synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
is_obsolete: true

[Term]
id: GO:0008472
name: metallocarboxypeptidase D activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22]
synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22]
synonym: "gp180 (duck)" RELATED [EC:3.4.17.22]
xref: EC:3.4.17.22
xref: MetaCyc:3.4.17.22-RXN
is_obsolete: true

[Term]
id: GO:0008487
name: prenyl-dependent CAAX protease activity
namespace: molecular_function
is_obsolete: true

[Term]
id: GO:0008533
name: astacin activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21]
subset: gosubset_prok
synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21]
synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21]
synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21]
xref: EC:3.4.24.21
xref: MetaCyc:3.4.24.21-RXN
is_obsolete: true

[Term]
id: GO:0008581
name: ubiquitin-specific protease 5 activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001]
synonym: "ubiquitin isopeptidase T activity" EXACT []
is_obsolete: true

[Term]
id: GO:0008717
name: D-alanyl-D-alanine endopeptidase activity
namespace: molecular_function
subset: gosubset_prok
synonym: "penicillin-binding protein 7" NARROW []
synonym: "penicillin-binding protein 8" NARROW []
xref: EC:3.4.99.-
is_obsolete: true

[Term]
id: GO:0008769
name: X-His dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3]
subset: gosubset_prok
synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "carnosinase activity" RELATED [EC:3.4.13.3]
synonym: "dipeptidase M" RELATED [EC:3.4.13.3]
synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3]
synonym: "Xaa-His dipeptidase activity" EXACT []
xref: EC:3.4.13.3
xref: MetaCyc:3.4.13.3-RXN
is_obsolete: true

[Term]
id: GO:0008846
name: endopeptidase La activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53]
subset: gosubset_prok
synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53]
synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53]
synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53]
synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53]
synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53]
synonym: "gene lon protease activity" EXACT [EC:3.4.21.53]
synonym: "gene lon proteins" RELATED [EC:3.4.21.53]
synonym: "lon proteinase" NARROW [EC:3.4.21.53]
synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53]
synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53]
synonym: "protease La" RELATED [EC:3.4.21.53]
synonym: "proteinase La" RELATED [EC:3.4.21.53]
synonym: "serine protease La" RELATED [EC:3.4.21.53]
xref: EC:3.4.21.53
xref: MetaCyc:3.4.21.53-RXN
is_obsolete: true

[Term]
id: GO:0008931
name: murein DD-endopeptidase activity
namespace: molecular_function
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0008944
name: oligopeptidase A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70]
subset: gosubset_prok
synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70]
xref: EC:3.4.24.70
xref: MetaCyc:3.4.24.70-RXN
is_obsolete: true

[Term]
id: GO:0008945
name: oligopeptidase B activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83]
subset: gosubset_prok
synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83]
synonym: "protease II activity" EXACT [EC:3.4.21.83]
xref: EC:3.4.21.83
xref: MetaCyc:3.4.21.83-RXN
is_obsolete: true

[Term]
id: GO:0008947
name: omptin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87]
subset: gosubset_prok
xref: EC:3.4.21.87
xref: MetaCyc:3.4.21.87-RXN
is_obsolete: true

[Term]
id: GO:0008956
name: peptidyl-dipeptidase Dcp activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5]
subset: gosubset_prok
synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5]
synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5]
xref: EC:3.4.15.5
xref: MetaCyc:3.4.15.5-RXN
is_obsolete: true

[Term]
id: GO:0008975
name: pitrilysin activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55]
subset: gosubset_prok
synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55]
synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55]
synonym: "protease III activity" EXACT [EC:3.4.24.55]
synonym: "protease Pi activity" EXACT [EC:3.4.24.55]
synonym: "proteinase Pi" RELATED [EC:3.4.24.55]
synonym: "PTR" RELATED [EC:3.4.24.55]
xref: EC:3.4.24.55
xref: MetaCyc:3.4.24.55-RXN
is_obsolete: true

[Term]
id: GO:0008978
name: prepilin peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43]
subset: gosubset_prok
xref: EC:3.4.23.43
xref: MetaCyc:3.4.23.43-RXN
is_obsolete: true

[Term]
id: GO:0008981
name: protease IV activity
namespace: molecular_function
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0008991
name: serine-type signal peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah]
xref: EC:3.4.21.-
is_obsolete: true

[Term]
id: GO:0008992
name: repressor LexA activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88]
subset: gosubset_prok
synonym: "LexA repressor" RELATED [EC:3.4.21.88]
synonym: "repressor lexA" RELATED [EC:3.4.21.88]
xref: EC:3.4.21.88
xref: MetaCyc:3.4.21.88-RXN
is_obsolete: true

[Term]
id: GO:0009003
name: signal peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah]
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0009004
name: signal peptidase I activity
namespace: molecular_function
def: "Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89]
subset: gosubset_prok
synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89]
synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89]
synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "HOSP" RELATED [EC:3.4.21.89]
synonym: "leader peptidase activity" EXACT [EC:3.4.21.89]
synonym: "leader peptidase I" RELATED [EC:3.4.21.89]
synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "leader proteinase activity" EXACT [EC:3.4.21.89]
synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89]
synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "propeptidase activity" EXACT [EC:3.4.21.89]
synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89]
synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "signal proteinase activity" EXACT [EC:3.4.21.89]
synonym: "signalase activity" EXACT [EC:3.4.21.89]
synonym: "SPase I activity" EXACT [EC:3.4.21.89]
synonym: "SPC" RELATED [EC:3.4.21.89]
xref: EC:3.4.21.89
xref: MetaCyc:3.4.21.89-RXN
is_obsolete: true

[Term]
id: GO:0009005
name: signal peptidase II activity
namespace: molecular_function
def: "Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36]
subset: gosubset_prok
synonym: "leader peptidase II" RELATED [EC:3.4.23.36]
synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36]
synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36]
synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "SPase II activity" EXACT [EC:3.4.23.36]
xref: EC:3.4.23.36
xref: MetaCyc:3.4.23.36-RXN
is_obsolete: true

[Term]
id: GO:0009049
name: aspartic-type signal peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah]
subset: gosubset_prok
xref: EC:3.4.23.-
is_obsolete: true

[Term]
id: GO:0009377
name: HslUV protease activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141]
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0009980
name: glutamate carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN]
subset: gosubset_prok
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11]
synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11]
synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11]
synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11]
synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11]
xref: EC:3.4.17.11
xref: MetaCyc:3.4.17.11-RXN
is_obsolete: true

[Term]
id: GO:0009983
name: tyrosine aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_obsolete: true

[Term]
id: GO:0010320
name: arginine/lysine endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators]
is_obsolete: true

[Term]
id: GO:0016284
name: alanine aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl]
subset: gosubset_prok
xref: EC:3.4.11.-
is_obsolete: true

[Term]
id: GO:0016285
name: cytosol alanyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14]
subset: gosubset_prok
synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14]
synonym: "arylamidase activity" NARROW [EC:3.4.11.14]
synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14]
synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14]
synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14]
synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14]
xref: EC:3.4.11.14
xref: MetaCyc:3.4.11.14-RXN
is_obsolete: true

[Term]
id: GO:0016511
name: endothelin-converting enzyme activity
namespace: molecular_function
subset: gosubset_prok
is_obsolete: true

[Term]
id: GO:0016512
name: endothelin-converting enzyme 1 activity
namespace: molecular_function
def: "Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71]
subset: gosubset_prok
synonym: "ECE-1 activity" EXACT [EC:3.4.24.71]
xref: EC:3.4.24.71
xref: MetaCyc:3.4.24.71-RXN
is_obsolete: true

[Term]
id: GO:0016804
name: prolyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5]
subset: gosubset_prok
synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5]
synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5]
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5]
synonym: "proline iminopeptidase activity" EXACT []
xref: EC:3.4.11.5
xref: MetaCyc:3.4.11.5-RXN
is_obsolete: true

[Term]
id: GO:0016808
name: proprotein convertase activity
namespace: molecular_function
xref: EC:3.4.21.-
is_obsolete: true

[Term]
id: GO:0016919
name: nardilysin activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61]
synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61]
xref: EC:3.4.24.61
xref: MetaCyc:3.4.24.61-RXN
is_obsolete: true

[Term]
id: GO:0016921
name: pyroglutamyl-peptidase II activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6]
synonym: "PAP-II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6]
synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6]
synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "TRH-DE activity" NARROW [EC:3.4.19.6]
synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6]
xref: EC:3.4.19.6
xref: MetaCyc:3.4.19.6-RXN
is_obsolete: true

[Term]
id: GO:0016946
name: cathepsin F activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]
xref: EC:3.4.22.41
xref: MetaCyc:3.4.22.41-RXN
is_obsolete: true

[Term]
id: GO:0017026
name: procollagen C-endopeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19]
synonym: "BMP1" NARROW []
synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19]
xref: EC:3.4.24.19
xref: MetaCyc:3.4.24.19-RXN
is_obsolete: true

[Term]
id: GO:0017039
name: dipeptidyl-peptidase III activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4]
subset: gosubset_prok
synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4]
synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4]
synonym: "DPP III activity" EXACT [EC:3.4.14.4]
synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4]
synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4]
xref: EC:3.4.14.4
xref: MetaCyc:3.4.14.4-RXN
is_obsolete: true

[Term]
id: GO:0017074
name: procollagen N-endopeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14]
synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type III procollagen" RELATED [EC:3.4.24.14]
xref: EC:3.4.24.14
xref: MetaCyc:3.4.24.14-RXN
is_obsolete: true

[Term]
id: GO:0017088
name: X-Pro dipeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11]
subset: gosubset_prok
synonym: "PepX" RELATED [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11]
synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT []
xref: EC:3.4.14.11
xref: MetaCyc:3.4.14.11-RXN
is_obsolete: true

[Term]
id: GO:0017092
name: sterol regulatory element-binding protein site 2 protease activity
namespace: molecular_function
def: "Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525]
synonym: "SREBP site 2 protease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0017093
name: sterol regulatory element-binding protein protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
synonym: "SREBP protease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0017094
name: sterol regulatory element-binding protein site 1 protease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525]
synonym: "SREBP site 1 protease activity" EXACT []
is_obsolete: true

[Term]
id: GO:0017165
name: dipeptidase E activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21]
subset: gosubset_prok
synonym: "alpha-aspartyl dipeptidase activity" EXACT []
synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21]
synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21]
synonym: "peptidase E activity" BROAD [EC:3.4.13.21]
xref: EC:3.4.13.21
xref: MetaCyc:3.4.13.21-RXN
is_obsolete: true

[Term]
id: GO:0019131
name: tripeptidyl-peptidase I activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9]
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9]
xref: EC:3.4.14.9
xref: MetaCyc:3.4.14.9-RXN
is_obsolete: true

[Term]
id: GO:0019132
name: C-terminal processing peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102]
subset: gosubset_prok
synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102]
synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102]
synonym: "protease Re" RELATED [EC:3.4.21.102]
synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102]
synonym: "Tsp protease" NARROW [EC:3.4.21.102]
xref: EC:3.4.21.102
xref: MetaCyc:3.4.21.102-RXN
is_obsolete: true

[Term]
id: GO:0019783
name: small conjugating protein-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups." [GOC:ma, GOC:mah]
subset: gosubset_prok
synonym: "ubiquitin-like specific protease activity" NARROW []
synonym: "ubiquitin-like-protein-specific protease activity" NARROW []
is_obsolete: true

[Term]
id: GO:0019784
name: NEDD8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah]
is_obsolete: true

[Term]
id: GO:0019785
name: ISG15-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah]
is_obsolete: true

[Term]
id: GO:0019786
name: APG8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah]
synonym: "APG8-PE hydrolase" RELATED []
is_obsolete: true

[Term]
id: GO:0030019
name: tryptase activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59]
subset: gosubset_prok
synonym: "lung tryptase activity" NARROW [EC:3.4.21.59]
synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59]
synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59]
synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59]
synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59]
synonym: "skin tryptase activity" NARROW [EC:3.4.21.59]
synonym: "tryptase M" RELATED [EC:3.4.21.59]
xref: EC:3.4.21.59
xref: MetaCyc:3.4.21.59-RXN
is_obsolete: true

[Term]
id: GO:0030271
name: chymase activity
namespace: molecular_function
def: "Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39]
synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39]
synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39]
synonym: "SK protease activity" EXACT [EC:3.4.21.39]
synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39]
synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39]
synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39]
xref: EC:3.4.21.39
xref: MetaCyc:3.4.21.39-RXN
is_obsolete: true

[Term]
id: GO:0030303
name: stromelysin 2 activity
namespace: molecular_function
def: "Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22]
synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22]
synonym: "MMP-10" EXACT []
synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22]
synonym: "transin 2 activity" EXACT [EC:3.4.24.22]
xref: EC:3.4.24.22
xref: MetaCyc:3.4.24.22-RXN
is_obsolete: true

[Term]
id: GO:0030402
name: matrilysin-2 activity
namespace: molecular_function
synonym: "matrix metalloproteinase 26" EXACT []
synonym: "MMP-26" EXACT []
xref: EC:3.4.24.-
is_obsolete: true

[Term]
id: GO:0030403
name: collagenase 4 activity
namespace: molecular_function
synonym: "matrix metalloproteinase 18" EXACT []
synonym: "MMP-18" NARROW []
is_obsolete: true

[Term]
id: GO:0030404
name: collagenase 3 activity
namespace: molecular_function
synonym: "matrix metalloproteinase 13" EXACT []
synonym: "MMP-13" EXACT []
is_obsolete: true

[Term]
id: GO:0030405
name: matrix metalloproteinase 19 activity
namespace: molecular_function
synonym: "MMP-19" EXACT []
is_obsolete: true

[Term]
id: GO:0030406
name: matrix metalloproteinase 25 activity
namespace: molecular_function
synonym: "MMP-25" EXACT []
synonym: "MT6-MMP" EXACT []
is_obsolete: true

[Term]
id: GO:0030601
name: aminopeptidase B activity
namespace: molecular_function
def: "Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6]
synonym: "arginyl aminopeptidase activity" EXACT []
synonym: "arylamidase II" RELATED [EC:3.4.11.6]
synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6]
synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
xref: EC:3.4.11.6
xref: MetaCyc:3.4.11.6-RXN
is_obsolete: true

[Term]
id: GO:0030602
name: chymosin activity
namespace: molecular_function
def: "Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4]
synonym: "rennin" RELATED [EC:3.4.23.4]
synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4]
xref: EC:3.4.23.4
xref: MetaCyc:3.4.23.4-RXN
is_obsolete: true

[Term]
id: GO:0030693
name: caspase activity
namespace: molecular_function
alt_id: GO:0004199
def: "Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455]
synonym: "caspase-1 activity" NARROW []
synonym: "caspase-10 activity" NARROW []
synonym: "caspase-2 activity" NARROW []
synonym: "caspase-3 activity" NARROW []
synonym: "caspase-4 activity" NARROW []
synonym: "caspase-5 activity" NARROW []
synonym: "caspase-6 activity" NARROW []
synonym: "caspase-7 activity" NARROW []
synonym: "caspase-8 activity" NARROW []
synonym: "caspase-9 activity" NARROW []
synonym: "effector caspase activity" NARROW []
synonym: "signaling (initiator) caspase activity" NARROW []
xref: Reactome:82077
is_obsolete: true

[Term]
id: GO:0031079
name: picornain 3C activity
namespace: molecular_function
def: "Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28]
synonym: "3C protease activity" EXACT [EC:3.4.22.28]
synonym: "3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "protease 3C" RELATED [EC:3.4.22.28]
synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28]
xref: EC:3.4.22.28
is_obsolete: true

[Term]
id: GO:0031368
name: Pro-X metallocarboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah]
synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-Xaa carboxypeptidase" NARROW []
synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16]
xref: EC:3.4.17.16
is_obsolete: true

[Term]
id: GO:0033264
name: bontoxilysin activity
namespace: molecular_function
def: "Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69]
subset: gosubset_prok
synonym: "BoNT" RELATED [EC:3.4.24.69]
synonym: "botulinum neurotoxin activity" EXACT []
xref: EC:3.4.24.69
xref: MetaCyc:3.4.24.69-RXN
is_obsolete: true

[Term]
id: GO:0042029
name: fibrolase activity
namespace: molecular_function
def: "Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320]
synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72]
xref: EC:3.4.24.72
xref: MetaCyc:3.4.24.72-RXN
is_obsolete: true

[Term]
id: GO:0042315
name: cytosol nonspecific dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18]
comment: Note that this function was formerly EC:3.4.3.1, EC:3.4.3.2, EC:3.4.3.6, EC:3.4.13.1, EC:3.4.13.2, EC:3.4.13.8, EC:3.4.13.11 and EC:3.4.13.15.
subset: gosubset_prok
synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "diglycinase activity" EXACT [EC:3.4.13.18]
synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "peptidase A activity" BROAD [EC:3.4.13.18]
synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolinase activity" NARROW [EC:3.4.13.18]
synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18]
xref: EC:3.4.13.18
xref: MetaCyc:3.4.13.18-RXN
is_obsolete: true

[Term]
id: GO:0042499
name: signal peptide peptidase activity
namespace: molecular_function
def: "Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416]
comment: Note that this function is distinct from the 'signal peptidases' (see the molecular function term 'signal peptidase activity ; GO:0009003' and its children). Broadly, signal peptidases cleave N-terminal leader sequences from secreted or membrane proteins, thereby creating signal peptides, while signal peptide peptidases cleave the signal peptides themselves.
synonym: "SPP" EXACT []
xref: EC:3.4.23.-
is_obsolete: true

[Term]
id: GO:0042576
name: aspartyl aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21]
subset: gosubset_prok
xref: EC:3.4.11.21
xref: MetaCyc:3.4.11.21-RXN
is_obsolete: true

[Term]
id: GO:0042708
name: elastase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of elastin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_obsolete: true

[Term]
id: GO:0043275
name: glutamate carboxypeptidase II activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl]
comment: Note that this function was formerly EC:3.4.19.8.
synonym: "acetylaspartylglutamate dipeptidase activity" EXACT []
synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "mGCP" RELATED [EC:3.4.17.21]
synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALADase activity" EXACT [EC:3.4.17.21]
synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "PSM antigen" RELATED [EC:3.4.17.21]
synonym: "PSMA" RELATED [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21]
xref: EC:3.4.17.21
is_obsolete: true

[Term]
id: GO:0043859
name: cyanophycinase activity
namespace: molecular_function
def: "Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200, UniProt:P58562]
subset: gosubset_prok
xref: EC:3.-.-.-
is_obsolete: true

[Term]
id: GO:0045024
name: peptidyl-glutamyl peptide hydrolyzing enzyme activity
namespace: molecular_function
def: "Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414]
is_obsolete: true

[Term]
id: GO:0046560
name: scytalidopepsin B activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32]
synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32]
synonym: "SLB" RELATED [EC:3.4.23.32]
xref: EC:3.4.23.32
xref: MetaCyc:3.4.23.32-RXN
is_obsolete: true

[Term]
id: GO:0046561
name: penicillopepsin activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20]
synonym: "acid protease A" EXACT []
synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "peptidase A activity" BROAD [EC:3.4.23.20]
xref: EC:3.4.23.20
xref: MetaCyc:3.4.23.20-RXN
is_obsolete: true

[Term]
id: GO:0050424
name: alanine carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN]
subset: gosubset_prok
synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6]
xref: EC:3.4.17.6
xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
is_obsolete: true

[Term]
id: GO:0050425
name: carboxypeptidase B activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN]
subset: gosubset_prok
synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2]
synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2]
synonym: "protaminase activity" RELATED [EC:3.4.17.2]
synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2]
xref: EC:3.4.17.2
xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN
is_obsolete: true

[Term]
id: GO:0050426
name: peptidyl-glycinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN]
synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2]
synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2]
xref: EC:3.4.19.2
xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN
is_obsolete: true

[Term]
id: GO:0051397
name: N-terminal basic amino acid aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai]
is_obsolete: true

[Term]
id: GO:0051398
name: N-terminal lysine aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
synonym: "lysine aminopeptidase activity" BROAD []
synonym: "lysyl aminopeptidase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0051399
name: N-terminal arginine aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
synonym: "arginine aminopeptidase activity" BROAD []
synonym: "argininyl aminopeptidase activity" BROAD []
is_obsolete: true

[Term]
id: GO:0051404
name: clostripain activity
namespace: molecular_function
def: "Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8]
synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8]
synonym: "clostridiopeptidase B activity" EXACT []
synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8]
xref: EC:3.4.22.8
is_obsolete: true

[Term]
id: GO:0051405
name: microbial collagenase activity
namespace: molecular_function
def: "Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3]
synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3]
synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3]
synonym: "azocollase activity" EXACT [EC:3.4.24.3]
synonym: "clostridiopeptidase A activity" EXACT []
synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3]
synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3]
synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3]
synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3]
synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3]
synonym: "collagen protease activity" EXACT [EC:3.4.24.3]
synonym: "collagenase 1 activity" EXACT []
synonym: "collagenase A activity" EXACT []
synonym: "collagenase I activity" EXACT [EC:3.4.24.3]
synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3]
synonym: "kollaza" RELATED [EC:3.4.24.3]
synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3]
synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3]
synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "nucleolysin" RELATED [EC:3.4.24.3]
synonym: "soycollagestin" RELATED [EC:3.4.24.3]
xref: EC:3.4.24.3
is_obsolete: true