Recent news

Cardiovascular Gene Annotation Newsletter May 2016

The UCL cardiovascular gene annotation newsletter is now available at https://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslett.... This newsletter highlights annotation of the miR-17~92 cluster, our RNA paper and our forthcoming 2-day bioinformatic resources workshop.

Paper on extending GO in the context of extracellular RNA and vesicle communication

To address the lack of standard terminology to describe extracellular RNA data and metadata, a team of several academic societies collaborated with the GO Consortium to extend the Gene Ontology with subcellular structure concepts relevant to the exRNA domain. As a result, exRNA data and metadata will be more easily annotated and queried because it will

GAF, GPAD and LEGO

The GO has historically provided access to annotations in a format called GAF (Gene Association Format). This format allows detailed representation of evidence and metadata for a GO term association, but has historically been limited in how well it can express important details of the cellular biology being described.

This has lead to a number of incremental improvements, while retaining compatibility, ultimately leading to the new expressive LEGO format.

Paper on GO-annotating key players in Parkinson's Disease published in Neuroinformatics

Read more about how we at UCL are using GO to annotate key players in Parkinson's disease. Our latest publication has just been published in Neuroinformatics: http://www.ncbi.nlm.nih.gov/pubmed/26825309.

Cardiovascular Gene Annotation Newsletter February 2016

The UCL cardiovascular gene annotation newsletter is now available at http://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslette... A new biocurator joins us this year, Barbara Czub, and we will be supervising 2 MSc student projects. In addition, Jess and Nancy have been annotating the telomere maintenance.

Connecting together multiple GO annotations: a report on the LEGO jamboree

In December, a group of us gathered at the Swiss Institute for Bioinformatics in Geneva to beta test and develop curation guidelines for a new GO annotation tool called Noctua. Noctua advances on the current GO annotation paradigm by allowing curators to connect together multiple annotations to give a cohesive picture of a biological process or mechanism.

To illustrate, consider the following two annotations which follow the current datamodel, which associates genes with GO terms:
  • TEM1 enables GTPase activity

Parkinson's Gene Annotation Project Newsletter, January 2016

The latest UCL Parkinson's UK gene annotation newsletter is now available at https://www.ucl.ac.uk/functional-gene-annotation/neurological/newsletter.... Rebecca has been annotating the role of Wnt-signalling in dopaminergic neuron development, and Paul has been focusing on autophagy. The Parkinson’s UK Gene Ontology Initiative represents a collaboration between University College London and the European Bioinformatics Institute (EBI) and is supported by Parkinson's UK grant G-1307.

Cardiovascular Gene Annotation Newsletter November 2015

The UCL cardiovascular gene annotation newsletter is now available at http://www.ucl.ac.uk/functional-gene-annotation/cardiovascular/newslette.... We have a new biocurator, Jess Buxton, a new look to our website, and our 2 MSc students have created 600 annotations between them. #UCLgene #UCL

Take the Gene Ontology Survey!

Survey Closed

The GO survey is now closed! You can still give us feedback on how we're doing or send us a note on twitter (@news4go).

Please assist the Gene Ontology (GO) project by completing a brief survey. The results will help us determine how we can make GO a better tool for your work, and will be used in preparation of our grant renewal. Completed surveys will be eligible for a prize draw.