format-version: 1.0 date: 17:05:2005 15:42 saved-by: jlomax auto-generated-by: DAG-Edit 1.419 rev 2 default-namespace: gene_ontology remark: cvs version: $Revision: 1.1 $ subsetdef: goslim_yeast "Yeast GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria\, including the mitochondrial genome\, into daughter cells after mitosis or meiosis\, mediated by interactions between mitochondria and the cytoskeleton." [PMID:10873824, PMID:11389764, SGD:mcc] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome." [GO:ai] is_a: GO:0007005 ! mitochondrion organization and biogenesis [Term] id: GO:0000003 name: reproduction alt_id: GO:0019952 namespace: biological_process def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GO:curators, ISBN:0198506732] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0007275 ! development [Term] id: GO:0000004 name: biological process unknown namespace: biological_process def: "Used for the annotation of gene products whose process is not known or cannot be inferred." [SGD:curators] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo\, but is not a component of the assembled ribosome when performing its normal biological function." [GO:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. To update annotations\, consider the molecular function term 'unfolded protein binding ; GO\:0051082' and the biological process term 'ribosome biogenesis and assembly ; GO\:0042254' and its children. is_obsolete: true [Term] id: GO:0000006 name: high affinity zinc uptake transporter activity namespace: molecular_function def: "Catalysis of the reaction\: Zn2+(out) = Zn2+(in)\, probably powered by proton motive force." [TC:2.A.5.1.1] xref_analog: TC:2.A.5.1.1 is_a: GO:0005385 ! zinc ion transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transporter activity namespace: molecular_function is_a: GO:0005385 ! zinc ion transporter activity [Term] id: GO:0000008 name: thioredoxin alt_id: GO:0000013 namespace: molecular_function def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism\, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide\, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [SP:kd] comment: This term was made obsolete because it represents gene products. To update annotations\, consider the molecular function term 'thiol-disulfide exchange intermediate activity ; GO\:0030508'. is_obsolete: true [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide\, forming an alpha-1\,6-linkage." [PMID:2644248, SGD:mcc] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction\: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] subset: gosubset_prok xref_analog: EC:2.5.1.30 xref_analog: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis\, mediated by interactions between vacuoles and the cytoskeleton." [PMID:10873824, PMID:14616069, SGD:mcc] is_a: GO:0007033 ! vacuole organization and biogenesis is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GO:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex\, usually a dimer or an octamer\, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GO:jl, ISBN:0198506732] subset: gosubset_prok exact_synonym: "enolase complex" [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction\: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] xref_analog: EC:3.2.1.108 xref_analog: MetaCyc:LACTASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into\, out of\, within or between cells. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue\, and the anomeric carbon of the bond is in an alpha configuration." [GO:jl, ISBN:0198506732, http://www.biochem.purdue.edu/] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of DNA recombination\, the processes by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GO:curators, ISBN:0198506732] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolism relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of DNA recombination during mitosis." [GO:curators] is_a: GO:0000018 ! regulation of DNA recombination relationship: part_of GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops\, prevents or reduces the rate of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GO:curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. To update annotations\, consider the biological process term 'negative regulation of mitotic recombination ; GO\:0045950'. is_obsolete: true [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [SGD:mah] exact_synonym: "spindle elongation during mitosis" [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0007052 ! mitotic spindle organization and biogenesis [Term] id: GO:0000023 name: maltose metabolism namespace: biological_process def: "The chemical reactions involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)\, an intermediate in the catabolism of glycogen and starch." [GO:jl, ISBN:0198506732] subset: gosubset_prok exact_synonym: "malt sugar metabolism" [] is_a: GO:0005984 ! disaccharide metabolism [Term] id: GO:0000024 name: maltose biosynthesis namespace: biological_process def: "The formation from simpler components of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GO:jl, ISBN:0198506732] subset: gosubset_prok exact_synonym: "malt sugar biosynthesis" [] is_a: GO:0000023 ! maltose metabolism is_a: GO:0046351 ! disaccharide biosynthesis [Term] id: GO:0000025 name: maltose catabolism namespace: biological_process def: "The breakdown into simpler components of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GO:jl, ISBN:0198506732] subset: gosubset_prok exact_synonym: "malt sugar catabolism" [] xref_analog: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolism is_a: GO:0046352 ! disaccharide catabolism [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide\, forming an alpha-1\,2-linkage." [PMID:10521541, SGD:mcc] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly and maintenance namespace: biological_process def: "The maintenance and assembly of the large ribosomal subunit from its constituent parts." [GO:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly [Term] id: GO:0000028 name: ribosomal small subunit assembly and maintenance namespace: biological_process def: "The maintenance and assembly of the small ribosomal subunit from its constituent parts." [GO:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule\, typically another carbohydrate or a lipid." [GO:ai] subset: gosubset_prok xref_analog: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of an mannosylphosphate group from one compound to another." [GO:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthesis namespace: biological_process def: "The formation from simpler components of cell wall mannoproteins\, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [GO:ai] subset: gosubset_prok is_a: GO:0006057 ! mannoprotein biosynthesis relationship: part_of GO:0007047 ! cell wall organization and biogenesis [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide\, forming an alpha-1\,3-linkage." [PMID:10521541, SGD:mcc] xref_analog: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction\: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok xref_analog: EC:3.5.4.2 xref_analog: MetaCyc:ADENINE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively with an acyl group\, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [ISBN:0198506732, http://cancerweb.ncl.ac.uk/] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function subset: gosubset_prok is_a: GO:0005386 ! carrier activity [Term] id: GO:0000038 name: very-long-chain fatty acid metabolism namespace: biological_process def: "The chemical reactions involving fatty acids with a chain length of C20 or greater." [MGI:hjd] subset: gosubset_prok is_a: GO:0006631 ! fatty acid metabolism [Term] id: GO:0000039 name: plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GO:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. To update annotations\, consider the molecular function term 'long-chain fatty acid transporter activity ; GO\:0005324' and the cellular component term 'plasma membrane ; GO\:0005886'. is_obsolete: true [Term] id: GO:0000040 name: low affinity iron ion transport namespace: biological_process is_a: GO:0006826 ! iron ion transport [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into\, out of\, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons\, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium\, manganese\, iron\, copper\, cobalt\, nickel\, molybdenum and silver." [ISBN:0198506732] subset: gosubset_prok exact_synonym: "transition metal transport" [] is_a: GO:0015674 ! di-, tri-valent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000042 name: protein-Golgi targeting namespace: biological_process def: "The process of directing proteins towards the Golgi using signals contained within the protein." [GO:ai] is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi is_a: GO:0006605 ! protein targeting [Term] id: GO:0000044 name: ascorbate stabilization namespace: biological_process def: "The reduction of the ascorbate free radical to a stable form." [GO:ai] subset: gosubset_prok synonym: "vitamin C stabilization" [] is_a: GO:0006118 ! electron transport [Term] id: GO:0000045 name: autophagic vacuole formation namespace: biological_process def: "The formation of a double membrane-bound structure\, the autophagosome\, that occurs when a specialized membrane sac\, called the isolation membrane\, starts to enclose a portion of the cytoplasm." [PMID:9412464] exact_synonym: "autophagosome formation" [] relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000046 name: autophagic vacuole fusion namespace: biological_process def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast\, inner membrane-bound structures (autophagic bodies) appear in the vacuole." [PMID:11099404] narrow_synonym: "fusion of autophagosome with lysosome" [] is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000047 name: Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GO:ai] comment: This term was made obsolete because it represents a gene product. To update annotations\, consider the molecular function term 'electron transporter activity ; GO\:0005489' and its children. synonym: "Rieske iron-sulphur protein" [] is_obsolete: true [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction\: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] xref_analog: EC:2.3.2.12 xref_analog: MetaCyc:PEPTIDYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Interacting selectively with transfer RNA." [GO:ai] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle alt_id: GO:0006594 alt_id: GO:0006871 namespace: biological_process def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [ISBN:0198506732] exact_synonym: "ornithine cycle" [] xref_analog: Reactome:70635 is_a: GO:0006807 ! nitrogen compound metabolism [Term] id: GO:0000051 name: urea cycle intermediate metabolism namespace: biological_process def: "The chemical reactions involving any of the intermediate compounds involved in the urea cycle\, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GO:jl "", ISBN:0198506732 ""] subset: gosubset_prok is_a: GO:0008152 ! metabolism relationship: part_of GO:0006807 ! nitrogen compound metabolism [Term] id: GO:0000052 name: citrulline metabolism namespace: biological_process def: "The chemical reactions involving citrulline\, N5-carbamoyl-L-ornithine\, an alpha amino acid not found in proteins." [ISBN:0198506732] subset: gosubset_prok is_a: GO:0000051 ! urea cycle intermediate metabolism is_a: GO:0019794 ! nonprotein amino acid metabolism [Term] id: GO:0000053 name: argininosuccinate metabolism namespace: biological_process def: "The chemical reactions involving argininosuccinate\, 2-(Nw-arginino)succinate\, an intermediate in the ornithine-urea cycle\, where it is synthesized from citrulline and aspartate." [ISBN:0198506732] is_a: GO:0000051 ! urea cycle intermediate metabolism [Term] id: GO:0000054 name: ribosome-nucleus export namespace: biological_process def: "The directed movement of a ribosome from the nucleus into the cytoplasm." [GO:ai] is_a: GO:0007046 ! ribosome biogenesis relationship: part_of GO:0006611 ! protein-nucleus export [Term] id: GO:0000055 name: ribosomal large subunit-nucleus export alt_id: GO:0000057 namespace: biological_process def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GO:mah ""] is_a: GO:0000054 ! ribosome-nucleus export [Term] id: GO:0000056 name: ribosomal small subunit-nucleus export alt_id: GO:0000058 namespace: biological_process def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GO:mah ""] is_a: GO:0000054 ! ribosome-nucleus export [Term] id: GO:0000059 name: protein-nucleus import, docking namespace: biological_process relationship: part_of GO:0006606 ! protein-nucleus import [Term] id: GO:0000060 name: protein-nucleus import, translocation namespace: biological_process def: "The vectorial transfer of a protein from the cytoplasm into the nucleus\, across the nuclear membrane." [GO:jl, ISBN:0198506732] relationship: part_of GO:0006606 ! protein-nucleus import [Term] id: GO:0000061 name: protein-nucleus import, substrate release namespace: biological_process relationship: part_of GO:0006606 ! protein-nucleus import [Term] id: GO:0000062 name: acyl-CoA binding namespace: molecular_function def: "Interacting selectively with acyl-CoA\, any derivative of coenzyme A in which the sulfhydryl group is in thioester linkage with a fatty acyl group." [GO:jl, ISBN:0198506732] subset: gosubset_prok is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0000064 name: L-ornithine transporter activity namespace: molecular_function def: "Enables the directed movement of L-ornithine\, 2\,5-diaminopentanoic acid\, into\, out of\, within or between cells." [GO:ai] subset: gosubset_prok xref_analog: Reactome:115868 xref_analog: Reactome:118497 xref_analog: Reactome:121106 xref_analog: Reactome:123243 xref_analog: Reactome:125346 xref_analog: Reactome:70633 is_a: GO:0015179 ! L-amino acid transporter activity [Term] id: GO:0000066 name: mitochondrial ornithine transport namespace: biological_process def: "The directed movement of ornithine\, 2\,5-diaminopentanoic acid\, into\, out of or within a mitochondrion." [GO:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015822 ! L-ornithine transport [Term] id: GO:0000067 name: DNA replication and chromosome cycle namespace: biological_process subset: gosubset_prok relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0000068 name: chromosome condensation namespace: biological_process def: "OBSOLETE. The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division in eukaryotic cells." [ISBN:0815316194, SGD:mah] comment: This term was made obsolete because its meaning was changed. To update annotations\, consider the biological process term 'chromosome condensation ; GO\:0030261'. is_obsolete: true [Term] id: GO:0000069 name: centromere and kinetochore complex maturation namespace: biological_process exact_synonym: "centromere/kinetochore complex maturation" [] relationship: part_of GO:0000067 ! DNA replication and chromosome cycle [Term] id: GO:0000070 name: mitotic sister chromatid segregation alt_id: GO:0016359 namespace: biological_process def: "The process by which replicated homologous chromosomes are physically separated into two sets during mitosis. Each replicated chromosome\, composed of two sister chromatids\, aligns at the cell equator\, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GO:ai] exact_synonym: "mitotic chromosome segregation" [] is_a: GO:0000819 ! sister chromatid segregation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000072 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [SGD:mah] synonym: "M-phase specific microtubule process" [] is_a: GO:0007017 ! microtubule-based process relationship: part_of GO:0000279 ! M phase [Term] id: GO:0000073 name: spindle pole body separation alt_id: GO:0030475 namespace: biological_process def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation\, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble.." [SGD:curators] exact_synonym: "spindle pole body separation (sensu Fungi)" [] narrow_synonym: "spindle pole body separation (sensu Saccharomyces)" [] relationship: part_of GO:0030471 ! spindle pole body and microtubule cycle (sensu Fungi) [Term] id: GO:0000074 name: regulation of cell cycle namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of the cell cycle." [GO:curators] subset: gosubset_prok exact_synonym: "cell cycle control" [] is_a: GO:0051244 ! regulation of cellular physiological process relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process def: "A point in the eukaryotic cell cycle where progress through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [ISBN:0815316194, SGD:mah] xref_analog: Reactome:69620 is_a: GO:0000074 ! regulation of cell cycle [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete\, thereby ensuring that progeny inherit a full complement of the genome." [PMID:11728327 "", PMID:12537518 "", SGD:rn ""] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A signal transduction pathway\, induced by DNA damage\, that blocks cell cycle progression (in G1\, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124] narrow_synonym: "DNA damage response\, signal transduction resulting in cell cycle arrest" [] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0042770 ! DNA damage response, signal transduction [Term] id: GO:0000078 name: cell morphogenesis checkpoint namespace: biological_process is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0000079 name: regulation of cyclin dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of CDK activity." [GO:curators] exact_synonym: "regulation of CDK activity" [] is_a: GO:0000074 ! regulation of cell cycle is_a: GO:0045859 ! regulation of protein kinase activity relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000080 name: G1 phase of mitotic cell cycle namespace: biological_process def: "Progression through G1 phase\, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [ISBN:0815316194] xref_analog: Reactome:69236 is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "Progression from G1 phase to S phase of the mitotic cell cycle." [SGD:mah] xref_analog: Reactome:69206 relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000083 name: G1/S-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1/S phase of the mitotic cell cycle." [GO:mah] xref_analog: Reactome:69205 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: S phase of mitotic cell cycle namespace: biological_process def: "Progression through S phase\, the part of the mitotic cell cycle during which DNA synthesis takes place." [ISBN:0815316194] is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000085 name: G2 phase of mitotic cell cycle namespace: biological_process def: "Progression through G2 phase\, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [ISBN:0815316194] xref_analog: Reactome:68911 is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "Progression from G2 phase to M phase of the mitotic cell cycle." [SGD:mah] xref_analog: Reactome:69275 relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000087 name: M phase of mitotic cell cycle namespace: biological_process def: "Progression through M phase\, the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [ISBN:0815316194, SGD:mah] synonym: "M-phase of mitotic cell cycle" [] xref_analog: Reactome:68886 is_a: GO:0000279 ! M phase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "Progression through prophase\, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [ISBN:0815316194] xref_analog: Reactome:68875 is_a: GO:0051324 ! prophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "Progression through metaphase\, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194] xref_analog: Reactome:68879 is_a: GO:0051323 ! metaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "Progression through anaphase\, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [ISBN:0815316194] xref_analog: Reactome:68882 is_a: GO:0051322 ! anaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "Progression through anaphase A\, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "Progression through anaphase B\, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "Progression through telophase\, the last of the stages of mitosis; in the canonical cell cycle\, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [ISBN:0721662544] is_a: GO:0051326 ! telophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000094 name: septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GO:curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. To update annotations\, consider the biological process term 'septin ring assembly ; GO\:0000921'\, 'barrier septum formation ; GO\:0000917'\, 'selection of site for barrier septum formation ; GO\:0000918'. is_obsolete: true [Term] id: GO:0000095 name: S-adenosylmethionine transporter activity namespace: molecular_function def: "Enables the directed movement of S-adenosylmethionine\, S-(5'-adenosyl)-L-methionine\, an important intermediate in one-carbon metabolism\, into\, out of\, within or between cells." [GO:ai] exact_synonym: "S-adenosyl methionine transporter activity" [] is_a: GO:0000099 ! sulfur amino acid transporter activity is_a: GO:0051184 ! cofactor transporter activity [Term] id: GO:0000096 name: sulfur amino acid metabolism namespace: biological_process def: "The chemical reactions involving amino acids containing sulfur\, comprising cysteine\, methionine and selenocysteine." [GO:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid metabolism" [] is_a: GO:0006520 ! amino acid metabolism is_a: GO:0006790 ! sulfur metabolism [Term] id: GO:0000097 name: sulfur amino acid biosynthesis namespace: biological_process def: "The formation from simpler components of amino acids containing sulfur\, comprising cysteine\, methionine and selenocysteine." [GO:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid biosynthesis" [] is_a: GO:0000096 ! sulfur amino acid metabolism is_a: GO:0008652 ! amino acid biosynthesis is_a: GO:0044272 ! sulfur compound biosynthesis [Term] id: GO:0000098 name: sulfur amino acid catabolism namespace: biological_process def: "The breakdown into simpler components of amino acids containing sulfur\, comprising cysteine\, methionine and selenocysteine." [GO:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid catabolism" [] is_a: GO:0000096 ! sulfur amino acid metabolism is_a: GO:0009063 ! amino acid catabolism is_a: GO:0044273 ! sulfur compound catabolism [Term] id: GO:0000099 name: sulfur amino acid transporter activity namespace: molecular_function def: "Enables the directed movement of amino acids containing sulfur (cystine\, methionine and their derivatives) into\, out of\, within or between cells." [GO:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid transporter activity" [] is_a: GO:0015171 ! amino acid transporter activity [Term] id: GO:0000100 name: S-methylmethionine transporter activity namespace: molecular_function def: "Enables the directed movement of S-methylmethionine into\, out of\, within or between cells." [GO:ai] subset: gosubset_prok is_a: GO:0000099 ! sulfur amino acid transporter activity [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine\, methionine and their derivatives) into\, out of\, within or between cells." [GO:ai] subset: gosubset_prok exact_synonym: "sulphur amino acid transport" [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0000102 name: L-methionine porter activity namespace: molecular_function xref_analog: TC:2.A.3.8.4 is_a: GO:0005294 ! neutral L-amino acid porter activity is_a: GO:0015191 ! L-methionine transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GO:jl] subset: gosubset_prok exact_synonym: "sulphate assimilation" [] is_a: GO:0006791 ! sulfur utilization [Term] id: GO:0000104 name: succinate dehydrogenase activity alt_id: GO:0019739 namespace: molecular_function def: "Catalysis of the reaction\: succinate + acceptor = fumarate + reduced acceptor. No reaction with quinols." [EC:1.3.99.1, SP:kd] subset: gosubset_prok exact_synonym: "fumarate reductase" [] xref_analog: EC:1.3.99.1 xref_analog: MetaCyc:SUCC-FUM-OXRED-A-RXN xref_analog: Reactome:118816 xref_analog: Reactome:70993 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthesis namespace: biological_process def: "The formation from simpler components of histidine\, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GO:curators] subset: gosubset_prok xref_analog: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolism is_a: GO:0009076 ! histidine family amino acid biosynthesis [Term] id: GO:0000107 name: imidazoleglycerol phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction\: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok broad_synonym: "glutamine amidotransferase\:cyclase" [] xref_analog: EC:2.4.2.- xref_analog: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: repairosome namespace: cellular_component def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER)\, such as DNA damage recognition\, DNA helix unwinding\, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] is_a: GO:0000109 ! nucleotide excision repair complex [Term] id: GO:0000109 name: nucleotide excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. is_a: GO:0043234 ! protein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000110 name: nucleotide excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide excision repair; possesses DNA damage recognition and endodeoxynuclease activities." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" [] is_a: GO:0000109 ! nucleotide excision repair complex [Term] id: GO:0000111 name: nucleotide excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide excision repair; possesses damaged DNA binding activity." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" [] is_a: GO:0000109 ! nucleotide excision repair complex [Term] id: GO:0000112 name: nucleotide excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide excision repair; possesses endodeoxynuclease and DNA helicase activities." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" [] is_a: GO:0000109 ! nucleotide excision repair complex [Term] id: GO:0000113 name: nucleotide excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" [] is_a: GO:0000109 ! nucleotide excision repair complex [Term] id: GO:0000114 name: G1-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G1 phase of the mitotic cell cycle." [GO:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0000115 name: S-phase-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the S phase of the mitotic cell cycle." [GO:mah] synonym: "S-specific transcription in mitotic cell cycle" [] xref_analog: Reactome:69241 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0000116 name: G2-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2 phase of the mitotic cell cycle." [GO:mah] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:0000117 name: G2/M-specific transcription in mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed during the G2/M phase of the mitotic cell cycle." [GO:mah] xref_analog: Reactome:69274 is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "Complex that possesses histone deacetylase activity." [GO:mah] comment: Note that this term represents a location\, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO\:0004407'. is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000119 name: mediator complex namespace: cellular_component def: "A protein complex that enables the RNA polymerase II-general RNA polymerase II transcription factor complex to react to transcriptional activator proteins; also enhances the level of basal transcription." [PMID:10384286, PMID:11114191, PMID:8187178, PMID:9396788, PMID:9774831] narrow_synonym: "TRAP complex" [] relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GO:mah] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction\: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] xref_analog: EC:3.1.3.21 xref_analog: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphoric monoester hydrolase activity [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops\, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GO:curators] exact_synonym: "negative regulation of transcription from Pol II promoter" [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "Complex that possesses histone acetyltransferase activity." [GO:mah] comment: Note that this term represents a location\, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO\:0004402'. exact_synonym: "histone acetylase complex" [] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p\, several proteins of the Spt and Ada families\, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions\, and usually contain homologs of the yeast proteins." [PMID:10637607] exact_synonym: "Spt-Ada-Gcn5-acetyltransferase complex" [] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex\, but includes fewer Spt and Ada proteins\, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO\:0000124'. is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor for eukaryotic RNA polymerase III promoters that is an RNA polymerase binding protein." [ISBN:0198547684, SGD:mah] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor for eukaryotic RNA polymerase III promoters." [ISBN:0198547684, SGD:mah] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "Non-sexual aggregation of single-celled organisms in culture." [GO:jl] is_a: GO:0007155 ! cell adhesion [Term] id: GO:0000131 name: incipient bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [SGD:clt] relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000132 name: establishment of mitotic spindle orientation alt_id: GO:0030607 alt_id: GO:0030609 namespace: biological_process def: "The processes that set the alignment of mitotic spindle relative to other cellular structures." [WB:ems] exact_synonym: "establishment of spindle orientation during mitosis" [] exact_synonym: "mitotic spindle orientation" [] exact_synonym: "orienting of mitotic spindle" [] narrow_synonym: "mitotic spindle orientation (sensu Fungi)" [] narrow_synonym: "mitotic spindle orientation (sensu Saccharomyces)" [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that helps determine cell polarity\, first described in yeast." [PMID:9632790] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005934 ! bud tip relationship: part_of GO:0005935 ! bud neck relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0000135 name: septin checkpoint namespace: biological_process is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0000136 name: mannosyltransferase complex namespace: cellular_component def: "A large\, multiprotein complex with alpha-1\,6 mannosyltransferase activity\, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [PMID:10037752, PMID:11095735, SGD:mcc] is_a: GO:0043234 ! protein complex relationship: part_of GO:0000137 ! Golgi cis cisterna [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GO:mah] is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction\: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] exact_synonym: "1-acyldihydroxyacetone-phosphate reductase" [] exact_synonym: "palmitoyldihydroxyacetone-phosphate reductase" [] xref_analog: EC:1.1.1.101 xref_analog: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref_analog: Reactome:76162 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: contractile ring (sensu Saccharomyces) namespace: cellular_component def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane at the mother-bud neck after mitosis. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [SGD:curators] exact_synonym: "actomyosin ring (sensu Saccharomyces)" [] exact_synonym: "cytokinetic ring (sensu Saccharomyces)" [] exact_synonym: "neck ring" [] is_a: GO:0030480 ! contractile ring (sensu Fungi) relationship: part_of GO:0005935 ! bud neck [Term] id: GO:0000144 name: septin ring (sensu Saccharomyces) namespace: cellular_component def: "Composed of the conserved family of filament forming proteins called septins as well as septin-associated proteins\, a septin ring initially forms in unbudded cells at the future site of bud emergence in close apposition to the cytoplasm face of plasma membrane. The ring expands into an hourglass shaped collar as the mother-bud neck develops during bud formation. The septin ring acts as a scaffold for other proteins that function at the bud neck and as a diffusion barrier to prevent the flow of some membrane proteins from the bud into the mother. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [SGD:curators] is_a: GO:0030481 ! septin ring (sensu Fungi) relationship: part_of GO:0000142 ! contractile ring (sensu Saccharomyces) [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "Protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] relationship: part_of GO:0005938 ! cell cortex [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament\, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GO:mah, ISBN:0815316194] is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch\, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GO:mah] is_a: GO:0030866 ! cortical actin cytoskeleton organization and biogenesis [Term] id: GO:0000148 name: 1,3-beta-glucan synthase complex namespace: cellular_component def: "The complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1\,3-beta-D-glucan chain." [EC:2.4.1.34] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005886 ! plasma membrane [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] exact_synonym: "SNAP receptor binding" [] is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [SGD:elh] comment: Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO\:0003690' and 'single-stranded DNA binding ; GO\:0003697'. subset: gosubset_prok narrow_synonym: "strand transferase" [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase (E3) and other proteins that may confer substrate specificity on the complex." [PMID:9529603] subset: gosubset_prok is_a: GO:0043234 ! protein complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [SGD:mah] is_a: GO:0000151 ! ubiquitin ligase complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [SGD:mah] is_a: GO:0000151 ! ubiquitin ligase complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000154 name: rRNA modification namespace: biological_process def: "The enzymatic modification of the chemical structure of specific sites in rRNA." [FB:ma] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0016072 ! rRNA metabolism [Term] id: GO:0000155 name: two-component sensor molecule activity namespace: molecular_function subset: gosubset_prok xref_analog: EC:2.7.3.- is_a: GO:0004673 ! protein-histidine kinase activity is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000156 name: two-component response regulator activity namespace: molecular_function subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0000158 name: protein phosphatase type 2A activity alt_id: GO:0008600 namespace: molecular_function def: "Catalysis of the reaction\: a phosphoprotein + H2O = a protein + phosphate. A protein serine/threonine phosphatase that is polycation-stimulated (PCS)\, being directly stimulated by protamine\, polylysine\, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine." [EC:3.1.3.16, ISBN:0198547684] exact_synonym: "protein phosphatase type 2A\, intrinsic catalyst activity" [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein serine/threonine phosphatase that is polycation-stimulated (PCS)\, being directly stimulated by protamine\, polylysine\, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine." [ISBN:0198547684] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0000160 name: two-component signal transduction system (phosphorelay) namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase that then acts as a phospho-donor to response regulator proteins; also known as histidyl-aspartyl phosphorelay." [PMID:9189755] subset: gosubset_prok is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0007165 ! signal transduction [Term] id: GO:0000161 name: MAPKKK cascade during osmolarity sensing namespace: biological_process def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007234 ! osmosensory signaling pathway via two-component system [Term] id: GO:0000162 name: tryptophan biosynthesis namespace: biological_process def: "The formation from simpler components of tryptophan\, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok xref_analog: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolism is_a: GO:0009096 ! aromatic amino acid family biosynthesis, anthranilate pathway is_a: GO:0046219 ! indolalkylamine biosynthesis [Term] id: GO:0000163 name: protein phosphatase type 1 activity alt_id: GO:0008598 namespace: molecular_function def: "Catalysis of the reaction\: a phosphoprotein + H2O = a protein + phosphate. An ATP\, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa\, which is subject to phosphorylation\, thus activating the phosphatase." [ISBN:0198547684, SGD:mah] exact_synonym: "protein phosphatase type 1\, intrinsic catalyst activity" [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "An ATP\, magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) that consists of a catalytic subunit of 38 kDa and a modulator subunit of 23 kDa\, which is subject to phosphorylation\, thus activating the phosphatase." [ISBN:0198547684, SGD:mah] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0000165 name: MAPKKK cascade namespace: biological_process def: "Cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [PMID:9561267, SGD:mah] is_a: GO:0007243 ! protein kinase cascade [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively with a nucleotide\, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety." [ISBN:0198547684, SGD:mah] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0000167 name: activation of MAPKKK during osmolarity sensing namespace: biological_process def: "Upregulation of MAPKKK activity in the context of osmolarity sensing." [PMID:9561267] is_a: GO:0000185 ! activation of MAPKKK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000168 name: activation of MAPKK during osmolarity sensing namespace: biological_process def: "Upregulation of a MAP kinase kinase in the context of osmolarity sensing." [PMID:9561267] is_a: GO:0000186 ! activation of MAPKK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000169 name: activation of MAPK during osmolarity sensing namespace: biological_process def: "Upregulation of MAP kinase activity in the context of osmolarity sensing." [PMID:9561267] is_a: GO:0000187 ! activation of MAPK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the first cleavage in rRNA transcript processing\, also involved in mitochondrial RNA processing." [PMID:10690410] exact_synonym: "RNase MRP" [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that performs the first cleavage in rRNA transcript processing and is also involved in mitochondrial RNA processing." [PMID:10690410] exact_synonym: "RNase MRP complex" [] exact_synonym: "ribonuclease mitochondrial RNA processing complex" [] is_a: GO:0030529 ! ribonucleoprotein complex relationship: part_of GO:0005730 ! nucleolus [Term] id: GO:0000173 name: inactivation of MAPK during osmolarity sensing namespace: biological_process def: "Downregulation of MAP kinase activity in the context of osmolarity sensing." [PMID:9561267] is_a: GO:0000188 ! inactivation of MAPK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000174 name: inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal\, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, use the biological process term 'signal transduction during conjugation with cellular fusion ; GO\:0000750'. is_obsolete: true [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [ISBN:0198547684, SGD:mah] subset: gosubset_prok exact_synonym: "3'-5' exoribonuclease activity" [] xref_analog: EC:3.1.13.- is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] is_a: GO:0000178 ! exosome (RNase complex) relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] is_a: GO:0000178 ! exosome (RNase complex) relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. is_a: GO:0043234 ! protein complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA\, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] subset: gosubset_prok xref_analog: EC:2.1.1.- is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GO:ai] comment: This term was made obsolete because more specific children exist. To update annotations\, consider the cellular component terms 'cytosolic large ribosomal subunit (sensu Bacteria) ; GO\:0009282' and 'cytosolic large ribosomal subunit (sensu Eukaryota) ; GO\:0005842'. is_obsolete: true [Term] id: GO:0000181 name: cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GO:ai] comment: This term was made obsolete because more specific children exist. To update annotations\, consider the cellular component terms 'cytosolic small ribosomal subunit (sensu Bacteria) ; GO\:0009283' and 'cytosolic small ribosomal subunit (sensu Eukaryota) ; GO\:0005843'. is_obsolete: true [Term] id: GO:0000182 name: ribosomal DNA (rDNA) binding namespace: molecular_function def: "Interacting selectively with DNA sequences encoding ribosomal RNA." [SGD:mah] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000183 name: chromatin silencing at ribosomal DNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by the formation of heterochromatin." [PMID:10219245] exact_synonym: "chromatin silencing at rDNA" [] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: mRNA catabolism, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated mRNA decay pathway degrades mRNAs transcribed from genes in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated\, and potentially harmful\, proteins." [FB:ma, PMID:10025395] subset: gosubset_prok exact_synonym: "mRNA catabolism\, nonsense-mediated" [] exact_synonym: "nonsense-mediated mRNA decay" [] is_a: GO:0006402 ! mRNA catabolism [Term] id: GO:0000185 name: activation of MAPKKK namespace: biological_process def: "Upregulation of MAPKKK activity in response to a signal." [PMID:9561267] exact_synonym: "activation of MAP kinase kinase kinase" [] exact_synonym: "positive regulation of MAP kinase kinase kinase activity" [] exact_synonym: "positive regulation of MAPKKK activity" [] is_a: GO:0045860 ! positive regulation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000186 name: activation of MAPKK alt_id: GO:0007255 namespace: biological_process def: "Upregulation of a MAP kinase kinase due to phosphorylation by a MAPKKK." [PMID:9561267] synonym: "activation of MAP/ERK kinase kinase" [] exact_synonym: "positive regulation of MAPKK activity" [] is_a: GO:0045860 ! positive regulation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000187 name: activation of MAPK namespace: biological_process def: "Upregulation of a MAP kinase activity due to phosphorylation by a MAPKK." [PMID:9561267] exact_synonym: "activation of MAP kinase" [] exact_synonym: "positive regulation of MAP kinase activity" [] exact_synonym: "positive regulation of MAPK activity" [] is_a: GO:0045860 ! positive regulation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000188 name: inactivation of MAPK namespace: biological_process def: "Downregulation of MAP kinase activity." [PMID:9561267] relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000189 name: nuclear translocation of MAPK namespace: biological_process def: "Movement of a MAP kinase from the cytoplasm to the nucleus upon activation." [PMID:9561267] is_a: GO:0000060 ! protein-nucleus import, translocation relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000190 name: MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000191 name: activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000192 name: activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000193 name: activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000194 name: inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000195 name: nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process term 'signal transduction during filamentous growth' (GO\:0001402). is_obsolete: true [Term] id: GO:0000196 name: MAPKKK cascade during cell wall biogenesis namespace: biological_process def: "MAPKKK cascade involved in pathway regulating cell wall integrity." [PMID:9561267] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007047 ! cell wall organization and biogenesis [Term] id: GO:0000197 name: activation of MAPKKK during cell wall biogenesis namespace: biological_process def: "Upregulation of MAPKKK activity in the context of regulating cell wall integrity." [PMID:9561267] is_a: GO:0000185 ! activation of MAPKKK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000198 name: activation of MAPKK during cell wall biogenesis namespace: biological_process def: "Upregulation of a MAP kinase kinase in the context of regulating cell wall integrity." [PMID:9561267] is_a: GO:0000186 ! activation of MAPKK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000199 name: activation of MAPK during cell wall biogenesis namespace: biological_process def: "Upregulation of MAP kinase activity in the context of regulating cell wall integrity." [PMID:9561267] is_a: GO:0000187 ! activation of MAPK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000200 name: inactivation of MAPK during cell wall biogenesis namespace: biological_process def: "Downregulation of MAP kinase activity in the context of regulating cell wall integrity." [PMID:9561267] is_a: GO:0000188 ! inactivation of MAPK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000201 name: nuclear translocation of MAPK during cell wall biogenesis namespace: biological_process def: "Movement of a MAP kinase to the nucleus in the context of regulating cell wall integrity." [PMID:9561267] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000196 ! MAPKKK cascade during cell wall biogenesis [Term] id: GO:0000202 name: MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000203 name: activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000204 name: activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000205 name: activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000206 name: inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000207 name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in\, but not restricted to\, the taxon Saccharomyces (Saccharomyces\, ncbi_taxonomy_id\:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. To update annotations\, consider the biological process terms 'sporulation (sensu Fungi)' ; GO\:0030437 or 'signal transduction' ; GO\:0007165. is_obsolete: true [Term] id: GO:0000208 name: nuclear translocation of MAPK during osmolarity sensing namespace: biological_process def: "Movement of a MAP kinase to the nucleus in the context of osmolarity sensing." [PMID:9561267] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000161 ! MAPKKK cascade during osmolarity sensing [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin moieties to a protein\, forming a ubiquitin chain." [ISBN:0815316194] subset: gosubset_prok exact_synonym: "protein polyubiquitinylation" [] exact_synonym: "protein polyubiquitylation" [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction\: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok exact_synonym: "NAD diphosphatase activity" [] exact_synonym: "NAD pyrophosphatase activity" [] xref_analog: EC:3.6.1.22 xref_analog: MetaCyc:NADPYROPHOSPHAT-RXN is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein\, targeting the tagged protein for destruction." [CGN:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. To update annotations\, consider the molecular function term 'protein binding ; GO\:0005515' and its children\, and the biological process terms 'protein ubiquitination during ubiquitin-dependent protein catabolism ; GO\:0042787' and 'modification-dependent protein catabolism ; GO\:0019941' and its children. is_obsolete: true [Term] id: GO:0000212 name: meiotic spindle organization and biogenesis namespace: biological_process def: "The formation and maintenance of the microtubule spindle during a meiotic cell cycle." [SGD:mah] exact_synonym: "spindle organization and biogenesis during meiosis" [] is_a: GO:0007051 ! spindle organization and biogenesis relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA\, producing 5'-hydroxyl and 2'\,3'-cyclic phosphate termini\, and specifically removing the intron." [EC:3.1.27.9] exact_synonym: "tRNA-splicing endonuclease" [] xref_analog: EC:3.1.27.9 xref_analog: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "Catalysis of the endonucleolytic cleavage of pre-tRNA\, producing 5'-hydroxyl and 2'\,3'-cyclic phosphate termini\, and specifically removing the intron." [EC:3.1.27.9] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [PMID:9148937] is_a: GO:0008665 ! 2'-phosphotransferase activity [Term] id: GO:0000216 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "Progression from M phase to G1 phase of the mitotic cell cycle." [SGD:mah] xref_analog: Reactome:68874 relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively with DNA containing secondary structure element such as cruciforms." [SGD:mah] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000219 name: vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GO:curators] comment: This term was made obsolete because more specific terms were created. To update annotations\, consider the cellular component term 'proton-transporting two-sector ATPase complex ; GO\:0016469' and its children. synonym: "V-ATPase" [] is_obsolete: true [Term] id: GO:0000220 name: hydrogen-transporting ATPase V0 domain namespace: cellular_component def: "The integral domain of the V-type ATPase comprises the pore through the membrane\, through which protons are translocated." [PMID:10224039, SGD:rb, TC:3.A.2.-.-] comment: Note that this domain often consists of five subunits\, although in some mammalian tissues it may have an additional subunit. is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex [Term] id: GO:0000221 name: hydrogen-transporting ATPase V1 domain namespace: cellular_component def: "The peripheral domain of the V-type ATPase contains the section responsible for ATP hydrolysis." [PMID:10224039, SGD:rb, TC:3.A.2.-.-] comment: Note that this domain generally consists of eight subunits. is_a: GO:0016471 ! hydrogen-translocating V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane hydrogen-transporting ATPase V0 domain namespace: cellular_component is_a: GO:0043234 ! protein complex relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0000223 name: plasma membrane hydrogen-transporting ATPase V1 domain namespace: cellular_component is_a: GO:0043234 ! protein complex relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated\, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "peptide\:N-glycanase" [] exact_synonym: "PNGase" [] xref_analog: EC:3.5.1.52 xref_analog: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction\: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI)\, used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89] comment: Note that this function was formerly EC\:3.1.1.69. xref_analog: EC:3.5.1.89 xref_analog: MetaCyc:3.1.1.69-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization and biogenesis namespace: biological_process def: "The assembly and arrangement of cytoskeletal structures comprising microtubules and their associated proteins." [SGD:mah] is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate carrier activity namespace: molecular_function xref_analog: TC:2.A.29.15.1 is_a: GO:0015131 ! oxaloacetate transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [SGD:mah] subset: goslim_generic is_a: GO:0005694 ! chromosome relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [SGD:mah] subset: goslim_generic subset: gosubset_prok is_a: GO:0005694 ! chromosome relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000230 name: nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [SGD:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations\, consider the cellular component term 'condensed nuclear chromosome ; GO\:0000794'. is_obsolete: true [Term] id: GO:0000231 name: cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [SGD:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations\, consider the cellular component term 'condensed chromosome ; GO\:0000793'. is_obsolete: true [Term] id: GO:0000232 name: nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [SGD:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations\, consider the cellular component term 'nuclear chromosome ; GO\: 0000228'. is_obsolete: true [Term] id: GO:0000233 name: cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [SGD:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. To update annotations\, consider the cellular component term 'cytoplasmic chromosome ; GO\:0000229'. is_obsolete: true [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction\: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] xref_analog: EC:2.1.1.103 xref_analog: MetaCyc:2.1.1.103-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "Progression through prometaphase\, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles\, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [ISBN:0198547684, SGD:mah] xref_analog: Reactome:68877 relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "Progression through the first stage of prophase I in meiosis\, in which chromosomes first become visible." [ISBN:0198547684] relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "Progression through the second stage of prophase I in meiosis\, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [ISBN:0198547684] relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "Progression through the third stage of prophase I in meiosis\, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [ISBN:0198547684] relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "Progression through the fourth stage of prophase I in meiosis\, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [ISBN:0198547684] relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "Progression through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [ISBN:0198547684] relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [ISBN:0815316194, SGD:clt] relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "The first portion of the spliceosome to assemble in mRNA splicing; in commitment complex formation the 5' and 3' splice sites are recognized by the U1 snRNP and the U2 snRNP auxiliary factor\, respectively." [PMID:9159080] exact_synonym: "E complex" [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005681 ! spliceosome complex [Term] id: GO:0000244 name: assembly of spliceosomal tri-snRNP namespace: biological_process def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] exact_synonym: "snRNP recycling" [] relationship: part_of GO:0000387 ! spliceosomal snRNP biogenesis [Term] id: GO:0000245 name: spliceosome assembly namespace: biological_process def: "Formation of the spliceosome\, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] is_a: GO:0006461 ! protein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction\: ergosterol + NADP+ = ergosta-5\,7\,22\,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850] subset: gosubset_prok exact_synonym: "D24(24-1)-sterol reductase activity" [] exact_synonym: "sterol delta-24(28) methylene reductase activity" [] exact_synonym: "sterol delta-24(28) reductase activity" [] xref_analog: EC:1.3.1.71 xref_analog: MetaCyc:1.3.1.71-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [SP:P32352] exact_synonym: "delta-8-delta-7 sterol isomerase" [] xref_analog: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of a C-5 double bond in the B ring of ergosterol." [SP:P32353] exact_synonym: "sterol-C5-desaturase" [] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain." [SP:P54781] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction\: (S)-2\,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7] subset: gosubset_prok exact_synonym: "2\,3-epoxysqualene-lanosterol cyclase" [] exact_synonym: "OSC" [] exact_synonym: "oxidosqualene-lanosterol cyclase" [] xref_analog: EC:5.4.99.7 xref_analog: MetaCyc:LANOSTEROL-SYNTHASE-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction\: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8\,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8\,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8\,24-dien-3-ol. synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" [] xref_analog: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction\: 4-alpha-methyl-5-alpha-cholesta-8\,24-dien-3-beta-ol + NADP+ = 4-alpha-methyl-5-alpha-cholesta-8\,24-dien-3-one + NADPH + H+." [EC:1.1.1.270, PMID:9811880] comment: Note that zymosterol is cholesta-8\,24-dien-3-ol. xref_analog: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction\: 4\,4-dimethyl-5-alpha-cholesta-8\,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8\,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8\,24-dien-3-ol. synonym: "methylsterol hydroxylase activity" [] synonym: "methylsterol monooxygenase activity" [] exact_synonym: "4-methylsterol oxidase activity" [] xref_analog: EC:1.14.13.- is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolism namespace: biological_process def: "The chemical reactions involving allantoin\, (2\,5-dioxo-4-imidazolidinyl)urea\, an intermediate or end product of purine catabolism." [ISBN:0198547684, SGD:mah] subset: gosubset_prok is_a: GO:0009308 ! amine metabolism is_a: GO:0046483 ! heterocycle metabolism [Term] id: GO:0000256 name: allantoin catabolism namespace: biological_process def: "The breakdown into simpler components of allantoin\, (2\,5-dioxo-4-imidazolidinyl)urea." [ISBN:0198547684, SGD:mah] subset: gosubset_prok is_a: GO:0000255 ! allantoin metabolism is_a: GO:0046700 ! heterocycle catabolism [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction\: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles\, and on the corresponding acid amides." [EC:3.5.5.1, SGD:kd] subset: gosubset_prok xref_analog: EC:3.5.5.1 xref_analog: MetaCyc:3.5.5.1-RXN xref_analog: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction\: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. To update annotations\, consider the molecular function terms 'L-isoleucine transporter activity ; GO\:0015188'\, 'L-valine transporter activity ; GO\:0005304'\, and 'sodium\:amino acid symporter activity ; GO\:0005283'. is_obsolete: true [Term] id: GO:0000259 name: intracellular nucleoside transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside\, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GO:ai] comment: This term was made obsolete because it contains component and function information. To update annotations\, use the molecular function term 'nucleoside transporter activity ; GO\:0005337' and the cellular component term 'intracellular ; GO\:0005622'. is_obsolete: true [Term] id: GO:0000260 name: hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction\: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. To update annotations\, use the molecular function term 'hydrogen-transporting ATPase activity\, rotational mechanism ; GO\:0046961'. is_obsolete: true [Term] id: GO:0000261 name: sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction\: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. To update annotations\, use the molecular function term 'sodium-transporting ATPase activity\, rotational mechanism ; GO\:0046962'. is_obsolete: true [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [SGD:mah] is_a: GO:0005694 ! chromosome relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [ISBN:0198547684, SGD:mah] comment: This term was made obsolete because it does not represent a molecular function. To update annotations\, consider the molecular function term 'GTPase activity ; GO\:0003924' and the cellular component term 'heterotrimeric G-protein complex ; GO\:0005834'. is_obsolete: true [Term] id: GO:0000264 name: heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [ISBN:0198547684, SGD:mah] comment: This term was made obsolete because it does not represent a molecular function. To update annotations\, consider the molecular function term 'GTPase activity ; GO\:0003924' and the cellular component term 'heterotrimeric G-protein complex ; GO\:0005834'. is_obsolete: true [Term] id: GO:0000265 name: heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [ISBN:0198547684, SGD:mah] comment: This term was made obsolete because it does not represent a molecular function. To update annotations\, consider the molecular function term 'GTPase activity ; GO\:0003924' and the cellular component term 'heterotrimeric G-protein complex ; GO\:0005834'. is_obsolete: true [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "Splitting of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] exact_synonym: "mitochondrial division" [] is_a: GO:0007005 ! mitochondrion organization and biogenesis is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: cell fraction namespace: cellular_component def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [FB:ma] comment: Note that this term refers to disrupted cells\, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok relationship: part_of GO:0005623 ! cell [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function def: "Interacting selectively with a peroxisomal targeting sequence\, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [ISBN:0879693568, SGD:mah] exact_synonym: "PTS binding" [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function xref_analog: TC:1.B.20.-.- is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolism alt_id: GO:0009284 namespace: biological_process def: "The chemical reactions involving peptidoglycans\, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [ISBN:0198506732, http://www.dsmz.de/species/murein.htm] subset: gosubset_prok exact_synonym: "murein metabolism" [] is_a: GO:0044262 ! cellular carbohydrate metabolism [Term] id: GO:0000271 name: polysaccharide biosynthesis namespace: biological_process def: "The formation from simpler components of polysaccharides\, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GO:curators] subset: gosubset_prok exact_synonym: "glycan biosynthesis" [] is_a: GO:0005976 ! polysaccharide metabolism is_a: GO:0016051 ! carbohydrate biosynthesis is_a: GO:0043284 ! biopolymer biosynthesis [Term] id: GO:0000272 name: polysaccharide catabolism namespace: biological_process def: "The breakdown into simpler components of polysaccharides\, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GO:curators] subset: gosubset_prok is_a: GO:0005976 ! polysaccharide metabolism is_a: GO:0016052 ! carbohydrate catabolism is_a: GO:0043285 ! biopolymer catabolism [Term] id: GO:0000273 name: lipoic acid metabolism namespace: biological_process def: "The chemical reactions involving lipoic acid\, 1\,2-dithiolane-3-pentanoic acid\, a coenzyme involved in oxidative decarboxylation of keto acids." [GO:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok is_a: GO:0006732 ! coenzyme metabolism is_a: GO:0019752 ! carboxylic acid metabolism is_a: GO:0046483 ! heterocycle metabolism [Term] id: GO:0000274 name: proton-transporting ATP synthase, stator stalk (sensu Eukaryota) namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. As in\, but not restricted to\, the eukaryotes (Eukaryota\, ncbi_taxonomy_id\:2759)." [PMID:10838056] exact_synonym: "hydrogen-transporting ATP synthase\, stator stalk (sensu Eukaryota)" [] is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk relationship: part_of GO:0000276 ! proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota) [Term] id: GO:0000275 name: proton-transporting ATP synthase complex, catalytic core F(1) (sensu Eukaryota) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk\, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. As in\, but not restricted to\, the eukaryotes (Eukaryota\, ncbi_taxonomy_id\:2759)." [PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO\:0005743'. broad_synonym: "hydrogen-transporting ATP synthase\, F1 sector" [] is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) relationship: part_of GO:0005753 ! proton-transporting ATP synthase complex (sensu Eukaryota) [Term] id: GO:0000276 name: proton-transporting ATP synthase complex, coupling factor F(o) (sensu Eukaryota) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase\, including integral and peripheral mitochondrial inner membrane proteins. As in\, but not restricted to\, the eukaryotes (Eukaryota\, ncbi_taxonomy_id\:2759)." [PMID:10838056] exact_synonym: "proton-transporting ATP synthase complex\, coupling factor F(0) (sensu Eukaryota)" [] broad_synonym: "hydrogen-transporting ATP synthase\, F0 sector" [] is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) relationship: part_of GO:0005753 ! proton-transporting ATP synthase complex (sensu Eukaryota) [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c; the reaction is S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine." [EC:2.1.1.59] xref_analog: EC:2.1.1.59 xref_analog: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle\, the most common eukaryotic cell cycle\, in which a cell is duplicated without changing ploidy; comprises four successive phases called G1\, S\, G2\, and M." [ISBN:0815316194, SGD:mah] xref_analog: Reactome:69278 is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "Progression through M phase\, the part of the cell cycle comprising nuclear division and cytokinesis." [ISBN:0815316194] exact_synonym: "M-phase" [] relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The partitioning of the nucleus and its genetic information." [FB:bf, GO:jl, http://www.biology-online.org/] synonym: "karyokinesis" [] is_a: GO:0050875 ! cellular physiological process [Term] id: GO:0000281 name: cytokinesis after mitosis namespace: biological_process def: "The processes resulting in the division of the cytoplasm of a cell after mitosis\, resulting in the separation of the original cell into two daughter cells." [GO:ai] is_a: GO:0000910 ! cytokinesis relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0000282 name: bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form\, in organisms that reproduce by budding." [SGD:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO\:0007115' (sibling term 'establishment of cell polarity (sensu Saccharomyces) ; GO\:0000283'). is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0030468 ! establishment of cell polarity (sensu Fungi) [Term] id: GO:0000284 name: shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [SGD:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. To update annotations\, use the biological process term 'cellular morphogenesis during conjugation with cellular fusion ; GO\:0000753'. is_obsolete: true [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction\: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3\,5-bisphosphate." [EC:2.7.1.150] xref_analog: EC:2.7.1.150 xref_analog: MetaCyc:2.7.1.150-RXN is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction\: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] subset: gosubset_prok xref_analog: EC:1.4.1.1 xref_analog: MetaCyc:ALANINE-DEHYDROGENASE-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively with magnesium (Mg) ions." [GO:ai] subset: gosubset_prok exact_synonym: "magnesium binding" [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: mRNA catabolism, deadenylylation-dependent decay namespace: biological_process def: "A major pathway of mRNA degradation\, that proceeds through a series of ordered steps\: poly(A) tail shortening\, deadenylylation-dependent decapping\, and decay of the transcript body\, and that can regulate mRNA stability." [SGD:krc] subset: gosubset_prok exact_synonym: "deadenylation-dependent mRNA decay" [] exact_synonym: "mRNA catabolism\, deadenylation-dependent" [] exact_synonym: "mRNA catabolism\, deadenylylation-dependent" [] is_a: GO:0006402 ! mRNA catabolism [Term] id: GO:0000289 name: poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of an mRNA from full length to an oligo(A) length." [SGD:krc] subset: gosubset_prok relationship: part_of GO:0000288 ! mRNA catabolism, deadenylylation-dependent decay [Term] id: GO:0000290 name: deadenylylation-dependent decapping namespace: biological_process def: "Cleavage of the 5'-cap of an mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [SGD:krc] exact_synonym: "deadenylation-dependent decapping" [] relationship: part_of GO:0000288 ! mRNA catabolism, deadenylylation-dependent decay [Term] id: GO:0000291 name: mRNA catabolism, exonucleolytic namespace: biological_process def: "Degradation of the mRNA transcript body that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [SGD:krc] subset: gosubset_prok exact_synonym: "exonucleolytic degradation of mRNA" [] is_a: GO:0006402 ! mRNA catabolism relationship: part_of GO:0000288 ! mRNA catabolism, deadenylylation-dependent decay relationship: part_of GO:0000294 ! mRNA catabolism, endonucleolytic cleavage-dependent decay [Term] id: GO:0000292 name: RNA fragment catabolism namespace: biological_process def: "The breakdown into simpler components of a fragment of RNA\, such as excised introns or sequences removed from ribosomal RNA during processing." [GO:mah ""] subset: gosubset_prok is_a: GO:0006401 ! RNA catabolism [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction\: 2 Fe(II) + NAD+ = 2 Fe(III) + NADH + H+." [EC:1.16.1.7] comment: Note that this function was formerly EC\:1.6.99.13. xref_analog: EC:1.16.1.7 xref_analog: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: mRNA catabolism, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor mRNA degradation pathway that begins with an endonucleolytic cleavage to generate unprotected ends." [SGD:krc] subset: gosubset_prok exact_synonym: "endonucleolytic mRNA decay" [] exact_synonym: "mRNA catabolism\, endonucleolytic" [] is_a: GO:0006402 ! mRNA catabolism [Term] id: GO:0000295 name: adenine nucleotide transporter activity namespace: molecular_function def: "Transports adenine nucleotides (AMP\, ADP\, and ATP) across membranes." [PMID:11566870] is_a: GO:0015216 ! purine nucleotide transporter activity [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine\, N\,N-bis(3-aminopropyl)-1\,4-diaminobutane\, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine\, into\, out of\, within or between cells." [ISBN:0198506732, SGD:krc] is_a: GO:0015846 ! polyamine transport [Term] id: GO:0000297 name: spermine transporter activity namespace: molecular_function def: "Enables the directed movement of spermine into\, out of\, within or between cells. Spermine is a polybasic amine found in human sperm\, in ribosomes and in some viruses\, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GO:ai] is_a: GO:0015203 ! polyamine transporter activity [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction\: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] xref_analog: EC:3.6.1.10 xref_analog: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: integral to membrane of membrane fraction namespace: cellular_component def: "Integral to that fraction of cells\, prepared by disruptive biochemical methods\, that includes the plasma and other membranes; require detergents\, such as Triton X-100\, to be released from membranes." [PMID:10512869] comment: Note that this term refers to disrupted cells\, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000300 name: peripheral to membrane of membrane fraction namespace: cellular_component def: "Peripheral to that fraction of cells\, prepared by disruptive biochemical methods\, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: Note that this term refers to disrupted cells\, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi\, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression\, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly\, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] exact_synonym: "retrograde (vesicle recycling within Golgi) transport" [] is_a: GO:0006891 ! intra-Golgi transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Responses induced by any reactive oxygen species\, including singlet oxygen\, superoxide\, and oxygen free radicals." [SGD:krc] subset: gosubset_prok is_a: GO:0006979 ! response to oxidative stress [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Responses induced by superoxide (the anion\, oxygen-\, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion)." [ISBN:0198506732, SGD:krc] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radicals [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "A change in state or activity of the organism (in terms of movement\, secretion\, enzyme production\, gene expression\, etc.) as a result of exposure to singlet oxygen\, a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin\, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [ISBN:0124325653, ISBN:0198506732, SGD:krc] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000305 name: response to oxygen radicals namespace: biological_process def: "Response induced by any oxygen radical (any oxygen species that carries a free electron\, examples include hydroxyl radicals and the superoxide anion)." [ISBN:0124325653, SGD:krc] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000306 name: extrinsic to vacuolar membrane namespace: cellular_component def: "Loosely bound to one or the other surface of the vacuolar membrane\, but not integrated into the hydrophobic region." [GO:jl, GO:mah "", http://cancerweb.ncl.ac.uk/] is_a: GO:0031312 ! extrinsic to organelle membrane relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [PMID:11602261, SGD:krc] exact_synonym: "CDK holoenzyme" [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [SGD:krc] broad_synonym: "CDK holoenzyme" [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction\: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] subset: gosubset_prok narrow_synonym: "NMN adenylyltransferase" [] xref_analog: EC:2.7.7.1 xref_analog: MetaCyc:2.7.7.1-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity alt_id: GO:0009043 namespace: molecular_function def: "Catalysis of the reaction\: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine." [EC:2.4.2.22, SGD:clt] subset: gosubset_prok exact_synonym: "xanthine-guanine phosphoribosyltransferase activity" [] xref_analog: EC:2.4.2.22 xref_analog: MetaCyc:XANPRIBOSYLTRAN-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation\: the aminoacyl site (A site) and peptidyl site (P site)." [SGD:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [SGD:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular organelle." [SGD:mcc] is_a: GO:0005840 ! ribosome [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [SGD:mcc] is_a: GO:0015935 ! small ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation\: the aminoacyl site (A site) and peptidyl site (P site)." [SGD:mcc] is_a: GO:0015934 ! large ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into\, out of\, within or between cells." [SGD:krc] exact_synonym: "sulphite transport" [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0000317 name: methionine-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction\: L-methionine S-oxide + reduced thioredoxin = L-methionine + oxidized thioredoxin; does not act on oxidized methionine in peptide linkage." [EC:1.8.4.5, PMID:11169920] subset: gosubset_prok exact_synonym: "methionine sulfoxide reductase" [] xref_analog: EC:1.8.4.5 xref_analog: MetaCyc:METHIONINE-S-OXIDE-REDUCTASE-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0000318 name: protein-methionine-R-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction\: L-methionine R-oxide + reduced thioredoxin = L-methionine + oxidized thioredoxin; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer." [EC:1.8.4.-, PMID:11929995] subset: gosubset_prok exact_synonym: "(protein) methionine-R-sulfoxide reductase" [] xref_analog: EC:1.8.4.- is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0000319 name: sulfite transporter activity namespace: molecular_function def: "Enables the directed movement of sulfite ions into\, out of\, within or between cells." [SGD:as] exact_synonym: "sulphite transporter activity" [] is_a: GO:0015103 ! inorganic anion transporter activity [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [SGD:krc] is_a: GO:0000074 ! regulation of cell cycle [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated." [PMID:9927449, SGD:krc] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation to pheromone during conjugation with cellular fusion [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials\, including nutrients\, pigments\, waste products\, and small molecules." [SGD:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes\, including a wide variety of acid hydrolases." [SGD:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: vacuole (sensu Fungi) namespace: cellular_component def: "The vacuole is a large\, membrane-bound organelle that functions as a reservoir for the storage of small molecules (including polyphosphate\, amino acids\, several divalent cations (e.g. calcium)\, other ions\, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment\, containing an ensemble of acid hydrolases. At least in S. cerevisiae\, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle\, with logarithmically growing cells having a multilobed\, reticulated vacuole\, while stationary phase cells contain a single large structure. As in\, but not restricted to\, the fungi (Fungi\, ncbi_taxonomy_id\:4751)." [ISBN:0879693649] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: vacuole (sensu Magnoliophyta) namespace: cellular_component def: "Cells contain one or several vacuoles\, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products\, as a degradative compartment\, as a cost-effective way of increasing cell size\, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. As in\, but not restricted to\, the flowering plants (Magnoliophyta\, ncbi_taxonomy_id\:3398)." [ISBN:0815316208] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A compound organelle of plants where there is a lytic vacuole within a storage vacuole." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! vacuole (sensu Magnoliophyta) [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bound compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole\, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole is_a: GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: vacuolar lumen (sensu Fungi) namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of the vacuole. As in\, but not restricted to\, the fungi (Fungi\, ncbi_taxonomy_id\:4751)." [SGD:krc] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! vacuole (sensu Fungi) [Term] id: GO:0000329 name: vacuolar membrane (sensu Fungi) namespace: cellular_component def: "The lipid bilayer separating the vacuole from the cytoplasm of the cell. As in\, but not restricted to\, the fungi (Fungi\, ncbi_taxonomy_id\:4751)." [SGD:krc] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000324 ! vacuole (sensu Fungi) [Term] id: GO:0000330 name: vacuolar lumen (sensu Magnoliophyta) namespace: cellular_component def: "The volume enclosed within the vacuolar membrane; as in\, but not restricted to\, the flowering plants (Magnoliophyta\, ncbi_taxonomy_id\:3398)." [SGD:krc] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! vacuole (sensu Magnoliophyta) [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells\, especially Protozoa\, that fills with water from the cytoplasm and then discharges this externally by the opening of a permanent narrow neck. Its function is probably osmoregulatory." [GO:jl, http://cancerweb.ncl.ac.uk/] is_a: GO:0005773 ! vacuole [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] exact_synonym: "telomerase\, template" [] relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] is_a: GO:0005697 ! telomerase holoenzyme complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction\: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde." [EC:1.13.11.6] subset: gosubset_prok xref_analog: EC:1.13.11.6 xref_analog: MetaCyc:1.13.11.6-RXN xref_analog: Reactome:114531 xref_analog: Reactome:116930 xref_analog: Reactome:119687 xref_analog: Reactome:122124 xref_analog: Reactome:124157 xref_analog: Reactome:71096 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of DNA transposition namespace: biological_process def: "Any process that stops\, prevents or reduces the rate of DNA transposition." [SGD:krc] subset: gosubset_prok is_a: GO:0000337 ! regulation of DNA transposition is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0000336 name: positive regulation of DNA transposition namespace: biological_process def: "Any process that activates or increases the rate of DNA transposition." [SGD:krc] subset: gosubset_prok is_a: GO:0000337 ! regulation of DNA transposition is_a: GO:0045911 ! positive regulation of DNA recombination [Term] id: GO:0000337 name: regulation of DNA transposition namespace: biological_process def: "Any process that modulates the frequency\, rate or extent of DNA transposition\, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [SGD:krc] subset: gosubset_prok is_a: GO:0000018 ! regulation of DNA recombination relationship: part_of GO:0006313 ! DNA transposition [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [SGD:krc] is_a: GO:0006464 ! protein modification [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule." [SGD:krc] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [SGD:krc] exact_synonym: "RNA m7G cap binding" [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively with the trimethylguanosine (m(3)(2\,2\,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures\, generally produced by posttranscriptional modification of a 7-methylguanosine cap\, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II\, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species\, e.g. C. elegans." [SGD:krc] exact_synonym: "RNA m2\,2\,7G cap binding" [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4)\: 7-methylguanosine-ppp-N6\, N6\, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3\, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [PMID:10880518, PMID:12121975, SGD:krc] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "The plastid-encoded plastid RNA polymerase A (PEP-A) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha\, beta\, and beta-prime subunits. An additional subunit\, a sigma factor\, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin\, like its precursor form the PEP-B complex." [PMID:10946105] exact_synonym: "PEP-A" [] is_a: GO:0030880 ! RNA polymerase complex relationship: part_of GO:0009536 ! plastid [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "The plastid-encoded plastid RNA polymerase B (PEP-B) is a plastid-encoded DNA-directed RNA polymerase that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha\, beta\, and beta-prime subunits. An additional subunit\, a sigma factor\, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts\, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] exact_synonym: "PEP-B" [] is_a: GO:0030880 ! RNA polymerase complex relationship: part_of GO:0009536 ! plastid [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase (sensu Bacteria) namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime\, beta\, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit\, a sigma factor\, is required for promoter recognition and specificity. As in\, but not restricted to\, the taxon Bacteria (Bacteria\, ncbi_taxonomy_id\:2)." [PMID:11158566] subset: gosubset_prok is_a: GO:0030880 ! RNA polymerase complex relationship: part_of GO:0005829 ! cytosol [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes\, including S. cerevisiae and metazoans." [PMID:11979277, SGD:krc] exact_synonym: "TREX complex" [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is an oligomeric complex\, primarily located in the nucleus\, that is involved in transcription elongation by RNA polymerase II and is crucial for transcription of certain coding regions. The complex\, though not each of the individual subunits\, is found in a range of eukaryotic organisms\, from S. cerevisiae to metazoans." [PMID:11060033, SGD:krc] is_a: GO:0043234 ! protein complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000348 name: nuclear mRNA branch site recognition namespace: biological_process def: "Recognition of the pre-mRNA branch site sequence by components of the assembling splice