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<!-- Title: ORTHOMCL6515 Pages: 1 -->
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<g id="edge15" class="edge"><title>GO:0008150&#45;&gt;GO:0009987</title>
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<g id="edge43" class="edge"><title>GO:0008150&#45;&gt;GO:0008152</title>
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<g id="edge3" class="edge"><title>GO:0051259&#45;&gt;GO:0051260</title>
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<g id="edge5" class="edge"><title>GO:0006461&#45;&gt;GO:0051259</title>
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<g id="edge7" class="edge"><title>GO:0065003&#45;&gt;GO:0006461</title>
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<g id="edge9" class="edge"><title>GO:0022607&#45;&gt;GO:0065003</title>
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<g id="edge25" class="edge"><title>GO:0016043&#45;&gt;GO:0006996</title>
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<text text-anchor="middle" x="1167" y="-121.667" style="font-family:Arial;font-size:10px;">DNA duplex unwinding</text>
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<!-- GO:0032508&#45;&gt;GO:0006268 -->
<g id="edge31" class="edge"><title>GO:0032508&#45;&gt;GO:0006268</title>
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</g>
<!-- GO:0032392 -->
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<text text-anchor="middle" x="1171" y="-207.667" style="font-family:Arial;font-size:10px;">DNA geometric</text>
<text text-anchor="middle" x="1171" y="-195.667" style="font-family:Arial;font-size:10px;">change</text>
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<!-- GO:0032392&#45;&gt;GO:0032508 -->
<g id="edge33" class="edge"><title>GO:0032392&#45;&gt;GO:0032508</title>
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</g>
<!-- GO:0006259 -->
<g id="node23" class="node"><title>GO:0006259</title>
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<text text-anchor="middle" x="1173" y="-275.667" style="font-family:Arial;font-size:10px;">DNA metabolic</text>
<text text-anchor="middle" x="1173" y="-263.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0006259&#45;&gt;GO:0032392 -->
<g id="edge35" class="edge"><title>GO:0006259&#45;&gt;GO:0032392</title>
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<!-- GO:0006260 -->
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<text text-anchor="middle" x="1289" y="-200.667" style="font-family:Arial;font-size:10px;">DNA replication</text>
</g>
<!-- GO:0006259&#45;&gt;GO:0006260 -->
<g id="edge69" class="edge"><title>GO:0006259&#45;&gt;GO:0006260</title>
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<!-- GO:0006139 -->
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<polygon style="fill:none;stroke:black;" points="935,-410 935,-476 1021,-476 1021,-410 935,-410"/>
<text text-anchor="middle" x="978" y="-465.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
<text text-anchor="middle" x="978" y="-453.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="978" y="-441.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
<text text-anchor="middle" x="978" y="-429.667" style="font-family:Arial;font-size:10px;">nucleic acid</text>
<text text-anchor="middle" x="978" y="-417.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0006139&#45;&gt;GO:0006259 -->
<g id="edge37" class="edge"><title>GO:0006139&#45;&gt;GO:0006259</title>
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<polygon style="fill:gray;stroke:gray;" points="1003.2,-399.9 1000,-410 1008.8,-404.1 1003.2,-399.9"/>
</g>
<!-- GO:0044237&#45;&gt;GO:0006139 -->
<g id="edge39" class="edge"><title>GO:0044237&#45;&gt;GO:0006139</title>
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</g>
<!-- GO:0044260 -->
<g id="node31" class="node"><title>GO:0044260</title>
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<polygon style="fill:none;stroke:black;" points="1181,-428 1181,-458 1287,-458 1287,-428 1181,-428"/>
<text text-anchor="middle" x="1234" y="-447.667" style="font-family:Arial;font-size:10px;">cellular macromolecule</text>
<text text-anchor="middle" x="1234" y="-435.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0044237&#45;&gt;GO:0044260 -->
<g id="edge63" class="edge"><title>GO:0044237&#45;&gt;GO:0044260</title>
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<polygon style="fill:gray;stroke:gray;" points="1134.04,-494.084 1127,-502 1137.44,-500.203 1134.04,-494.084"/>
</g>
<!-- GO:0044249 -->
<g id="node38" class="node"><title>GO:0044249</title>
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<polygon style="fill:none;stroke:black;" points="1055,-428 1055,-458 1147,-458 1147,-428 1055,-428"/>
<text text-anchor="middle" x="1101" y="-447.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
<text text-anchor="middle" x="1101" y="-435.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0044237&#45;&gt;GO:0044249 -->
<g id="edge87" class="edge"><title>GO:0044237&#45;&gt;GO:0044249</title>
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<polygon style="fill:gray;stroke:gray;" points="1096.51,-491.701 1099,-502 1103.48,-492.398 1096.51,-491.701"/>
</g>
<!-- GO:0008152&#45;&gt;GO:0044237 -->
<g id="edge41" class="edge"><title>GO:0008152&#45;&gt;GO:0044237</title>
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<polygon style="fill:gray;stroke:gray;" points="1133.45,-559.404 1143,-564 1138.4,-554.454 1133.45,-559.404"/>
</g>
<!-- GO:0044238 -->
<g id="node27" class="node"><title>GO:0044238</title>
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<polygon style="fill:none;stroke:black;" points="937,-502 937,-532 1021,-532 1021,-502 937,-502"/>
<text text-anchor="middle" x="979" y="-521.667" style="font-family:Arial;font-size:10px;">primary metabolic</text>
<text text-anchor="middle" x="979" y="-509.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0044238 -->
<g id="edge49" class="edge"><title>GO:0008152&#45;&gt;GO:0044238</title>
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<polygon style="fill:gray;stroke:gray;" points="1115.42,-564.479 1126,-564 1117.43,-557.774 1115.42,-564.479"/>
</g>
<!-- GO:0043170 -->
<g id="node30" class="node"><title>GO:0043170</title>
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<polygon style="fill:none;stroke:black;" points="1290,-502 1290,-532 1376,-532 1376,-502 1290,-502"/>
<text text-anchor="middle" x="1333" y="-521.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1333" y="-509.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0043170 -->
<g id="edge57" class="edge"><title>GO:0008152&#45;&gt;GO:0043170</title>
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<polygon style="fill:gray;stroke:gray;" points="1186.57,-557.774 1178,-564 1188.58,-564.479 1186.57,-557.774"/>
</g>
<!-- GO:0009058 -->
<g id="node37" class="node"><title>GO:0009058</title>
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<polygon style="fill:none;stroke:black;" points="1174,-502 1174,-532 1232,-532 1232,-502 1174,-502"/>
<text text-anchor="middle" x="1203" y="-521.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1203" y="-509.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0009058 -->
<g id="edge79" class="edge"><title>GO:0008152&#45;&gt;GO:0009058</title>
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<polygon style="fill:gray;stroke:gray;" points="1163.6,-554.454 1159,-564 1168.55,-559.404 1163.6,-554.454"/>
</g>
<!-- GO:0044238&#45;&gt;GO:0006139 -->
<g id="edge47" class="edge"><title>GO:0044238&#45;&gt;GO:0006139</title>
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<polygon style="fill:gray;stroke:gray;" points="975.5,-492 979,-502 982.5,-492 975.5,-492"/>
</g>
<!-- GO:0034960 -->
<g id="node28" class="node"><title>GO:0034960</title>
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<polygon style="fill:none;stroke:black;" points="1245,-336 1245,-366 1333,-366 1333,-336 1245,-336"/>
<text text-anchor="middle" x="1289" y="-355.667" style="font-family:Arial;font-size:10px;">cellular biopolymer</text>
<text text-anchor="middle" x="1289" y="-343.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0034960&#45;&gt;GO:0006259 -->
<g id="edge51" class="edge"><title>GO:0034960&#45;&gt;GO:0006259</title>
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<polygon style="fill:gray;stroke:gray;" points="1256.9,-332.8 1267,-336 1261.1,-327.2 1256.9,-332.8"/>
</g>
<!-- GO:0034961 -->
<g id="node34" class="node"><title>GO:0034961</title>
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<polygon style="fill:none;stroke:black;" points="1245,-250 1245,-292 1333,-292 1333,-250 1245,-250"/>
<text text-anchor="middle" x="1289" y="-281.667" style="font-family:Arial;font-size:10px;">cellular biopolymer</text>
<text text-anchor="middle" x="1289" y="-269.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1289" y="-257.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0034960&#45;&gt;GO:0034961 -->
<g id="edge91" class="edge"><title>GO:0034960&#45;&gt;GO:0034961</title>
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</g>
<!-- GO:0043283 -->
<g id="node29" class="node"><title>GO:0043283</title>
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<polygon style="fill:none;stroke:black;" points="1427,-428 1427,-458 1525,-458 1525,-428 1427,-428"/>
<text text-anchor="middle" x="1476" y="-447.667" style="font-family:Arial;font-size:10px;">biopolymer metabolic</text>
<text text-anchor="middle" x="1476" y="-435.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0043283&#45;&gt;GO:0034960 -->
<g id="edge53" class="edge"><title>GO:0043283&#45;&gt;GO:0034960</title>
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<!-- GO:0043284 -->
<g id="node39" class="node"><title>GO:0043284</title>
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<polygon style="fill:none;stroke:black;" points="1367,-336 1367,-366 1475,-366 1475,-336 1367,-336"/>
<text text-anchor="middle" x="1421" y="-355.667" style="font-family:Arial;font-size:10px;">biopolymer biosynthetic</text>
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<!-- GO:0043283&#45;&gt;GO:0043284 -->
<g id="edge97" class="edge"><title>GO:0043283&#45;&gt;GO:0043284</title>
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<!-- GO:0043170&#45;&gt;GO:0043283 -->
<g id="edge55" class="edge"><title>GO:0043170&#45;&gt;GO:0043283</title>
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<!-- GO:0043170&#45;&gt;GO:0044260 -->
<g id="edge61" class="edge"><title>GO:0043170&#45;&gt;GO:0044260</title>
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<!-- GO:0009059 -->
<g id="node36" class="node"><title>GO:0009059</title>
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<polygon style="fill:none;stroke:black;" points="1321,-422 1321,-464 1393,-464 1393,-422 1321,-422"/>
<text text-anchor="middle" x="1357" y="-453.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1357" y="-441.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1357" y="-429.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0043170&#45;&gt;GO:0009059 -->
<g id="edge81" class="edge"><title>GO:0043170&#45;&gt;GO:0009059</title>
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<!-- GO:0044260&#45;&gt;GO:0034960 -->
<g id="edge59" class="edge"><title>GO:0044260&#45;&gt;GO:0034960</title>
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<!-- GO:0034645 -->
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<polygon style="fill:none;stroke:black;" points="1105,-330 1105,-372 1211,-372 1211,-330 1105,-330"/>
<text text-anchor="middle" x="1158" y="-361.667" style="font-family:Arial;font-size:10px;">cellular macromolecule</text>
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<!-- GO:0044260&#45;&gt;GO:0034645 -->
<g id="edge89" class="edge"><title>GO:0044260&#45;&gt;GO:0034645</title>
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<!-- GO:0006261 -->
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<polygon style="fill:none;stroke:black;" points="1253,-109 1253,-139 1327,-139 1327,-109 1253,-109"/>
<text text-anchor="middle" x="1290" y="-128.667" style="font-family:Arial;font-size:10px;">DNA&#45;dependent</text>
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<!-- GO:0006261&#45;&gt;GO:0006268 -->
<g id="edge65" class="edge"><title>GO:0006261&#45;&gt;GO:0006268</title>
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<!-- GO:0006260&#45;&gt;GO:0006261 -->
<g id="edge67" class="edge"><title>GO:0006260&#45;&gt;GO:0006261</title>
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<!-- GO:0034961&#45;&gt;GO:0006260 -->
<g id="edge71" class="edge"><title>GO:0034961&#45;&gt;GO:0006260</title>
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<g id="edge73" class="edge"><title>GO:0034645&#45;&gt;GO:0034961</title>
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<g id="edge75" class="edge"><title>GO:0009059&#45;&gt;GO:0034645</title>
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<g id="edge95" class="edge"><title>GO:0009059&#45;&gt;GO:0043284</title>
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<!-- GO:0009058&#45;&gt;GO:0009059 -->
<g id="edge77" class="edge"><title>GO:0009058&#45;&gt;GO:0009059</title>
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<g id="edge85" class="edge"><title>GO:0009058&#45;&gt;GO:0044249</title>
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<!-- GO:0044249&#45;&gt;GO:0034645 -->
<g id="edge83" class="edge"><title>GO:0044249&#45;&gt;GO:0034645</title>
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<!-- GO:0043284&#45;&gt;GO:0034961 -->
<g id="edge93" class="edge"><title>GO:0043284&#45;&gt;GO:0034961</title>
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<!-- GO:0043231 -->
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<text text-anchor="middle" x="358" y="-213.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="358" y="-201.667" style="font-family:Arial;font-size:10px;">membrane&#45;bounded</text>
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