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<g id="node38" class="node"><title>GO:0044445</title>
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<g id="edge85" class="edge"><title>GO:0005829&#45;&gt;GO:0044445</title>
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<g id="node15" class="node"><title>GO:0042981</title>
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<text text-anchor="middle" x="2533" y="-463.667" style="font-family:Arial;font-size:10px;">apoptosis</text>
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<g id="node30" class="node"><title>GO:0044444</title>
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<g id="edge51" class="edge"><title>GO:0005737&#45;&gt;GO:0044444</title>
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<g id="node17" class="node"><title>GO:0005815</title>
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<g id="edge3" class="edge"><title>GO:0005815&#45;&gt;GO:0005813</title>
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<g id="node88" class="node"><title>GO:0044450</title>
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<g id="edge343" class="edge"><title>GO:0005815&#45;&gt;GO:0044450</title>
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<text text-anchor="middle" x="490" y="-257.667" style="font-family:Arial;font-size:10px;">part</text>
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<!-- GO:0044430&#45;&gt;GO:0005815 -->
<g id="edge5" class="edge"><title>GO:0044430&#45;&gt;GO:0005815</title>
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<g id="edge339" class="edge"><title>GO:0044430&#45;&gt;GO:0044450</title>
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<!-- GO:0044446 -->
<g id="node19" class="node"><title>GO:0044446</title>
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<text text-anchor="middle" x="610" y="-447.667" style="font-family:Arial;font-size:10px;">organelle part</text>
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<g id="edge7" class="edge"><title>GO:0044446&#45;&gt;GO:0044430</title>
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<g id="edge9" class="edge"><title>GO:0044422&#45;&gt;GO:0044446</title>
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<g id="edge13" class="edge"><title>GO:0043226&#45;&gt;GO:0044422</title>
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<g id="node26" class="node"><title>GO:0043229</title>
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<polygon style="fill:none;stroke:black;" points="490,-538 490,-568 546,-568 546,-538 490,-538"/>
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<text text-anchor="middle" x="518" y="-545.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<!-- GO:0043226&#45;&gt;GO:0043229 -->
<g id="edge33" class="edge"><title>GO:0043226&#45;&gt;GO:0043229</title>
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<g id="node29" class="node"><title>GO:0043228</title>
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<g id="edge43" class="edge"><title>GO:0043226&#45;&gt;GO:0043228</title>
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<g id="node90" class="node"><title>GO:0043227</title>
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<text text-anchor="middle" x="410" y="-545.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<g id="edge349" class="edge"><title>GO:0043226&#45;&gt;GO:0043227</title>
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<g id="node22" class="node"><title>GO:0044424</title>
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<text text-anchor="middle" x="699" y="-637.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="699" y="-625.667" style="font-family:Arial;font-size:10px;">part</text>
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<g id="edge53" class="edge"><title>GO:0044424&#45;&gt;GO:0005737</title>
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<!-- GO:0044424&#45;&gt;GO:0044446 -->
<g id="edge17" class="edge"><title>GO:0044424&#45;&gt;GO:0044446</title>
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<g id="edge35" class="edge"><title>GO:0044424&#45;&gt;GO:0043229</title>
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<g id="edge49" class="edge"><title>GO:0044424&#45;&gt;GO:0044444</title>
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<!-- GO:0044464&#45;&gt;GO:0044424 -->
<g id="edge19" class="edge"><title>GO:0044464&#45;&gt;GO:0044424</title>
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<!-- GO:0044464&#45;&gt;GO:0005622 -->
<g id="edge29" class="edge"><title>GO:0044464&#45;&gt;GO:0005622</title>
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<g id="edge23" class="edge"><title>GO:0005623&#45;&gt;GO:0044464</title>
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<g id="edge31" class="edge"><title>GO:0043229&#45;&gt;GO:0044446</title>
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<g id="node28" class="node"><title>GO:0043232</title>
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<g id="edge45" class="edge"><title>GO:0043229&#45;&gt;GO:0043232</title>
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<g id="node89" class="node"><title>GO:0043231</title>
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<text text-anchor="middle" x="488" y="-453.667" style="font-family:Arial;font-size:10px;">membrane&#45;bounded</text>
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<g id="edge351" class="edge"><title>GO:0043229&#45;&gt;GO:0043231</title>
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<polygon style="fill:none;stroke:black;" points="365,-343 365,-359 427,-359 427,-343 365,-343"/>
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<g id="edge37" class="edge"><title>GO:0005856&#45;&gt;GO:0044430</title>
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<g id="edge57" class="edge"><title>GO:0005856&#45;&gt;GO:0015630</title>
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<g id="edge41" class="edge"><title>GO:0043228&#45;&gt;GO:0043232</title>
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<g id="edge87" class="edge"><title>GO:0044444&#45;&gt;GO:0005829</title>
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<g id="edge47" class="edge"><title>GO:0044444&#45;&gt;GO:0005815</title>
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<g id="edge83" class="edge"><title>GO:0044444&#45;&gt;GO:0044445</title>
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<g id="edge341" class="edge"><title>GO:0044444&#45;&gt;GO:0044450</title>
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<g id="node91" class="node"><title>GO:0005768</title>
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<text text-anchor="middle" x="605" y="-348.667" style="font-family:Arial;font-size:10px;">endosome</text>
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<!-- GO:0044444&#45;&gt;GO:0005768 -->
<g id="edge357" class="edge"><title>GO:0044444&#45;&gt;GO:0005768</title>
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<!-- GO:0015630&#45;&gt;GO:0005815 -->
<g id="edge55" class="edge"><title>GO:0015630&#45;&gt;GO:0005815</title>
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<!-- GO:0005488&#45;&gt;GO:0005515 -->
<g id="edge63" class="edge"><title>GO:0005488&#45;&gt;GO:0005515</title>
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<!-- GO:0015631 -->
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</g>
<!-- GO:0015631&#45;&gt;GO:0043015 -->
<g id="edge67" class="edge"><title>GO:0015631&#45;&gt;GO:0043015</title>
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<!-- GO:0008092&#45;&gt;GO:0015631 -->
<g id="edge69" class="edge"><title>GO:0008092&#45;&gt;GO:0015631</title>
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<!-- GO:0031082 -->
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<text text-anchor="middle" x="800" y="-194.667" style="font-family:Arial;font-size:10px;">BLOC complex</text>
</g>
<!-- GO:0031082&#45;&gt;GO:0031083 -->
<g id="edge73" class="edge"><title>GO:0031082&#45;&gt;GO:0031083</title>
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</g>
<!-- GO:0043234 -->
<g id="node36" class="node"><title>GO:0043234</title>
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<polygon style="fill:none;stroke:black;" points="858,-257 858,-273 934,-273 934,-257 858,-257"/>
<text text-anchor="middle" x="896" y="-262.667" style="font-family:Arial;font-size:10px;">protein complex</text>
</g>
<!-- GO:0043234&#45;&gt;GO:0000930 -->
<g id="edge335" class="edge"><title>GO:0043234&#45;&gt;GO:0000930</title>
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</g>
<!-- GO:0043234&#45;&gt;GO:0031082 -->
<g id="edge75" class="edge"><title>GO:0043234&#45;&gt;GO:0031082</title>
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<!-- GO:0032991&#45;&gt;GO:0043234 -->
<g id="edge77" class="edge"><title>GO:0032991&#45;&gt;GO:0043234</title>
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<!-- GO:0044445&#45;&gt;GO:0031082 -->
<g id="edge81" class="edge"><title>GO:0044445&#45;&gt;GO:0031082</title>
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<!-- GO:0006357 -->
<g id="node39" class="node"><title>GO:0006357</title>
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<polygon style="fill:none;stroke:black;" points="1493,-96 1493,-150 1595,-150 1595,-96 1493,-96"/>
<text text-anchor="middle" x="1544" y="-139.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1544" y="-127.667" style="font-family:Arial;font-size:10px;">transcription</text>
<text text-anchor="middle" x="1544" y="-115.667" style="font-family:Arial;font-size:10px;">from RNA polymerase</text>
<text text-anchor="middle" x="1544" y="-103.667" style="font-family:Arial;font-size:10px;">II promoter</text>
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<!-- GO:0006357&#45;&gt;GO:0045944 -->
<g id="edge89" class="edge"><title>GO:0006357&#45;&gt;GO:0045944</title>
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</g>
<!-- GO:0006355 -->
<g id="node40" class="node"><title>GO:0006355</title>
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<polygon style="fill:none;stroke:black;" points="1580,-176 1580,-218 1654,-218 1654,-176 1580,-176"/>
<text text-anchor="middle" x="1617" y="-207.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1617" y="-195.667" style="font-family:Arial;font-size:10px;">transcription,</text>
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<!-- GO:0006355&#45;&gt;GO:0006357 -->
<g id="edge91" class="edge"><title>GO:0006355&#45;&gt;GO:0006357</title>
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</g>
<!-- GO:0045893 -->
<g id="node75" class="node"><title>GO:0045893</title>
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<polygon style="fill:none;stroke:black;" points="1629,-102 1629,-144 1713,-144 1713,-102 1629,-102"/>
<text text-anchor="middle" x="1671" y="-133.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="1671" y="-121.667" style="font-family:Arial;font-size:10px;">of transcription,</text>
<text text-anchor="middle" x="1671" y="-109.667" style="font-family:Arial;font-size:10px;">DNA&#45;dependent</text>
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<!-- GO:0006355&#45;&gt;GO:0045893 -->
<g id="edge241" class="edge"><title>GO:0006355&#45;&gt;GO:0045893</title>
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<polygon style="fill:gray;stroke:gray;" points="1635.2,-165.9 1632,-176 1640.8,-170.1 1635.2,-165.9"/>
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<!-- GO:0045449 -->
<g id="node41" class="node"><title>GO:0045449</title>
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<polygon style="fill:none;stroke:black;" points="1650,-250 1650,-280 1710,-280 1710,-250 1650,-250"/>
<text text-anchor="middle" x="1680" y="-269.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1680" y="-257.667" style="font-family:Arial;font-size:10px;">transcription</text>
</g>
<!-- GO:0045449&#45;&gt;GO:0006355 -->
<g id="edge93" class="edge"><title>GO:0045449&#45;&gt;GO:0006355</title>
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<!-- GO:0045941 -->
<g id="node76" class="node"><title>GO:0045941</title>
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<polygon style="fill:none;stroke:black;" points="1839,-182 1839,-212 1923,-212 1923,-182 1839,-182"/>
<text text-anchor="middle" x="1881" y="-201.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="1881" y="-189.667" style="font-family:Arial;font-size:10px;">of transcription</text>
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<!-- GO:0045449&#45;&gt;GO:0045941 -->
<g id="edge309" class="edge"><title>GO:0045449&#45;&gt;GO:0045941</title>
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<!-- GO:0010468 -->
<g id="node42" class="node"><title>GO:0010468</title>
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<polygon style="fill:none;stroke:black;" points="1571,-538 1571,-568 1649,-568 1649,-538 1571,-538"/>
<text text-anchor="middle" x="1610" y="-557.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1610" y="-545.667" style="font-family:Arial;font-size:10px;">gene expression</text>
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<!-- GO:0010468&#45;&gt;GO:0045449 -->
<g id="edge95" class="edge"><title>GO:0010468&#45;&gt;GO:0045449</title>
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</g>
<!-- GO:0010628 -->
<g id="node82" class="node"><title>GO:0010628</title>
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<polygon style="fill:none;stroke:black;" points="1838,-440 1838,-470 1926,-470 1926,-440 1838,-440"/>
<text text-anchor="middle" x="1882" y="-459.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="1882" y="-447.667" style="font-family:Arial;font-size:10px;">of gene expression</text>
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<!-- GO:0010468&#45;&gt;GO:0010628 -->
<g id="edge279" class="edge"><title>GO:0010468&#45;&gt;GO:0010628</title>
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<!-- GO:0060255 -->
<g id="node43" class="node"><title>GO:0060255</title>
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<polygon style="fill:none;stroke:black;" points="1643,-612 1643,-654 1729,-654 1729,-612 1643,-612"/>
<text text-anchor="middle" x="1686" y="-643.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1686" y="-631.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1686" y="-619.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0060255&#45;&gt;GO:0010468 -->
<g id="edge97" class="edge"><title>GO:0060255&#45;&gt;GO:0010468</title>
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<!-- GO:0010556 -->
<g id="node50" class="node"><title>GO:0010556</title>
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<polygon style="fill:none;stroke:black;" points="1759,-526 1759,-580 1831,-580 1831,-526 1759,-526"/>
<text text-anchor="middle" x="1795" y="-569.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1795" y="-557.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1795" y="-545.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
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<!-- GO:0060255&#45;&gt;GO:0010556 -->
<g id="edge131" class="edge"><title>GO:0060255&#45;&gt;GO:0010556</title>
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</g>
<!-- GO:0051252 -->
<g id="node70" class="node"><title>GO:0051252</title>
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<polygon style="fill:none;stroke:black;" points="1528,-330 1528,-372 1600,-372 1600,-330 1528,-330"/>
<text text-anchor="middle" x="1564" y="-361.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1564" y="-349.667" style="font-family:Arial;font-size:10px;">RNA metabolic</text>
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<!-- GO:0060255&#45;&gt;GO:0051252 -->
<g id="edge217" class="edge"><title>GO:0060255&#45;&gt;GO:0051252</title>
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</g>
<!-- GO:0010604 -->
<g id="node81" class="node"><title>GO:0010604</title>
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<polygon style="fill:none;stroke:black;" points="1903,-532 1903,-574 1989,-574 1989,-532 1903,-532"/>
<text text-anchor="middle" x="1946" y="-563.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="1946" y="-551.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
<text text-anchor="middle" x="1946" y="-539.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0060255&#45;&gt;GO:0010604 -->
<g id="edge271" class="edge"><title>GO:0060255&#45;&gt;GO:0010604</title>
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</g>
<!-- GO:0019222 -->
<g id="node44" class="node"><title>GO:0019222</title>
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<polygon style="fill:none;stroke:black;" points="2031,-696 2031,-726 2117,-726 2117,-696 2031,-696"/>
<text text-anchor="middle" x="2074" y="-715.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="2074" y="-703.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0019222&#45;&gt;GO:0060255 -->
<g id="edge99" class="edge"><title>GO:0019222&#45;&gt;GO:0060255</title>
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</g>
<!-- GO:0009889 -->
<g id="node51" class="node"><title>GO:0009889</title>
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<polygon style="fill:none;stroke:black;" points="1927,-612 1927,-654 1985,-654 1985,-612 1927,-612"/>
<text text-anchor="middle" x="1956" y="-643.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1956" y="-631.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1956" y="-619.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0019222&#45;&gt;GO:0009889 -->
<g id="edge125" class="edge"><title>GO:0019222&#45;&gt;GO:0009889</title>
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<polygon style="fill:gray;stroke:gray;" points="2040.9,-692.8 2051,-696 2045.1,-687.2 2040.9,-692.8"/>
</g>
<!-- GO:0031323 -->
<g id="node55" class="node"><title>GO:0031323</title>
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<polygon style="fill:none;stroke:black;" points="2095,-612 2095,-654 2177,-654 2177,-612 2095,-612"/>
<text text-anchor="middle" x="2136" y="-643.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="2136" y="-631.667" style="font-family:Arial;font-size:10px;">cellular metabolic</text>
<text text-anchor="middle" x="2136" y="-619.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0019222&#45;&gt;GO:0031323 -->
<g id="edge143" class="edge"><title>GO:0019222&#45;&gt;GO:0031323</title>
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<polygon style="fill:gray;stroke:gray;" points="2089.2,-685.9 2086,-696 2094.8,-690.1 2089.2,-685.9"/>
</g>
<!-- GO:0009893 -->
<g id="node79" class="node"><title>GO:0009893</title>
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<polygon style="fill:none;stroke:black;" points="2211,-612 2211,-654 2295,-654 2295,-612 2211,-612"/>
<text text-anchor="middle" x="2253" y="-643.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2253" y="-631.667" style="font-family:Arial;font-size:10px;">of metabolic</text>
<text text-anchor="middle" x="2253" y="-619.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0019222&#45;&gt;GO:0009893 -->
<g id="edge253" class="edge"><title>GO:0019222&#45;&gt;GO:0009893</title>
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</g>
<!-- GO:0050789&#45;&gt;GO:0019222 -->
<g id="edge101" class="edge"><title>GO:0050789&#45;&gt;GO:0019222</title>
<path style="fill:none;stroke:gray;" d="M2247,-774C2207,-760 2152,-740 2115,-726"/>
<polygon style="fill:gray;stroke:gray;" points="2245.41,-777.158 2256,-777 2247.62,-770.517 2245.41,-777.158"/>
</g>
<!-- GO:0050794 -->
<g id="node56" class="node"><title>GO:0050794</title>
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<polygon style="fill:none;stroke:black;" points="2307,-696 2307,-726 2381,-726 2381,-696 2307,-696"/>
<text text-anchor="middle" x="2344" y="-715.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="2344" y="-703.667" style="font-family:Arial;font-size:10px;">cellular process</text>
</g>
<!-- GO:0050789&#45;&gt;GO:0050794 -->
<g id="edge147" class="edge"><title>GO:0050789&#45;&gt;GO:0050794</title>
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<polygon style="fill:gray;stroke:gray;" points="2307.8,-766.559 2306,-777 2313.92,-769.958 2307.8,-766.559"/>
</g>
<!-- GO:0050789&#45;&gt;GO:0048518 -->
<g id="edge257" class="edge"><title>GO:0050789&#45;&gt;GO:0048518</title>
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<polygon style="fill:gray;stroke:gray;" points="2276.2,-771.1 2285,-777 2281.8,-766.9 2276.2,-771.1"/>
</g>
<!-- GO:0050793 -->
<g id="node93" class="node"><title>GO:0050793</title>
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<text text-anchor="middle" x="2487" y="-709.667" style="font-family:Arial;font-size:10px;">developmental</text>
<text text-anchor="middle" x="2487" y="-697.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0050789&#45;&gt;GO:0050793 -->
<g id="edge363" class="edge"><title>GO:0050789&#45;&gt;GO:0050793</title>
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<!-- GO:0065007&#45;&gt;GO:0050789 -->
<g id="edge103" class="edge"><title>GO:0065007&#45;&gt;GO:0050789</title>
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<!-- GO:0008152&#45;&gt;GO:0019222 -->
<g id="edge109" class="edge"><title>GO:0008152&#45;&gt;GO:0019222</title>
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<!-- GO:0043170 -->
<g id="node48" class="node"><title>GO:0043170</title>
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<text text-anchor="middle" x="1573" y="-715.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1573" y="-703.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0008152&#45;&gt;GO:0043170 -->
<g id="edge115" class="edge"><title>GO:0008152&#45;&gt;GO:0043170</title>
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<!-- GO:0009058 -->
<g id="node52" class="node"><title>GO:0009058</title>
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<polygon style="fill:none;stroke:black;" points="1823,-696 1823,-726 1881,-726 1881,-696 1823,-696"/>
<text text-anchor="middle" x="1852" y="-715.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1852" y="-703.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0008152&#45;&gt;GO:0009058 -->
<g id="edge129" class="edge"><title>GO:0008152&#45;&gt;GO:0009058</title>
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<!-- GO:0044237 -->
<g id="node58" class="node"><title>GO:0044237</title>
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<text text-anchor="middle" x="1956" y="-715.667" style="font-family:Arial;font-size:10px;">cellular metabolic</text>
<text text-anchor="middle" x="1956" y="-703.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0008152&#45;&gt;GO:0044237 -->
<g id="edge155" class="edge"><title>GO:0008152&#45;&gt;GO:0044237</title>
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<!-- GO:0044238 -->
<g id="node60" class="node"><title>GO:0044238</title>
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<polygon style="fill:none;stroke:black;" points="1290,-696 1290,-726 1374,-726 1374,-696 1290,-696"/>
<text text-anchor="middle" x="1332" y="-715.667" style="font-family:Arial;font-size:10px;">primary metabolic</text>
<text text-anchor="middle" x="1332" y="-703.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0008152&#45;&gt;GO:0044238 -->
<g id="edge165" class="edge"><title>GO:0008152&#45;&gt;GO:0044238</title>
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<!-- GO:0008152&#45;&gt;GO:0009893 -->
<g id="edge261" class="edge"><title>GO:0008152&#45;&gt;GO:0009893</title>
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<!-- GO:0043170&#45;&gt;GO:0060255 -->
<g id="edge113" class="edge"><title>GO:0043170&#45;&gt;GO:0060255</title>
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<polygon style="fill:black;stroke:black;" points="1600.9,-687.2 1595,-696 1605.1,-692.8 1600.9,-687.2"/>
</g>
<!-- GO:0010467 -->
<g id="node49" class="node"><title>GO:0010467</title>
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<polygon style="fill:none;stroke:black;" points="1425,-625 1425,-641 1503,-641 1503,-625 1425,-625"/>
<text text-anchor="middle" x="1464" y="-630.667" style="font-family:Arial;font-size:10px;">gene expression</text>
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<!-- GO:0043170&#45;&gt;GO:0010467 -->
<g id="edge119" class="edge"><title>GO:0043170&#45;&gt;GO:0010467</title>
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<!-- GO:0009059 -->
<g id="node53" class="node"><title>GO:0009059</title>
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<polygon style="fill:none;stroke:black;" points="1537,-612 1537,-654 1609,-654 1609,-612 1537,-612"/>
<text text-anchor="middle" x="1573" y="-643.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
<text text-anchor="middle" x="1573" y="-631.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="1573" y="-619.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0043170&#45;&gt;GO:0009059 -->
<g id="edge137" class="edge"><title>GO:0043170&#45;&gt;GO:0009059</title>
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<!-- GO:0044260 -->
<g id="node66" class="node"><title>GO:0044260</title>
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<text text-anchor="middle" x="1300" y="-637.667" style="font-family:Arial;font-size:10px;">cellular macromolecule</text>
<text text-anchor="middle" x="1300" y="-625.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0043170&#45;&gt;GO:0044260 -->
<g id="edge193" class="edge"><title>GO:0043170&#45;&gt;GO:0044260</title>
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<!-- GO:0043283 -->
<g id="node68" class="node"><title>GO:0043283</title>
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<text text-anchor="middle" x="1126" y="-637.667" style="font-family:Arial;font-size:10px;">biopolymer metabolic</text>
<text text-anchor="middle" x="1126" y="-625.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0043170&#45;&gt;GO:0043283 -->
<g id="edge201" class="edge"><title>GO:0043170&#45;&gt;GO:0043283</title>
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<!-- GO:0043170&#45;&gt;GO:0010604 -->
<g id="edge273" class="edge"><title>GO:0043170&#45;&gt;GO:0010604</title>
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<!-- GO:0010467&#45;&gt;GO:0010468 -->
<g id="edge117" class="edge"><title>GO:0010467&#45;&gt;GO:0010468</title>
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<!-- GO:0006350 -->
<g id="node63" class="node"><title>GO:0006350</title>
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<text text-anchor="middle" x="1298" y="-348.667" style="font-family:Arial;font-size:10px;">transcription</text>
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<!-- GO:0010467&#45;&gt;GO:0006350 -->
<g id="edge211" class="edge"><title>GO:0010467&#45;&gt;GO:0006350</title>
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<!-- GO:0010467&#45;&gt;GO:0010628 -->
<g id="edge283" class="edge"><title>GO:0010467&#45;&gt;GO:0010628</title>
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<!-- GO:0010556&#45;&gt;GO:0045449 -->
<g id="edge121" class="edge"><title>GO:0010556&#45;&gt;GO:0045449</title>
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<!-- GO:0010557 -->
<g id="node77" class="node"><title>GO:0010557</title>
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<polygon style="fill:none;stroke:black;" points="1960,-428 1960,-482 2044,-482 2044,-428 1960,-428"/>
<text text-anchor="middle" x="2002" y="-471.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2002" y="-459.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
<text text-anchor="middle" x="2002" y="-447.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2002" y="-435.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0010556&#45;&gt;GO:0010557 -->
<g id="edge265" class="edge"><title>GO:0010556&#45;&gt;GO:0010557</title>
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<!-- GO:0009889&#45;&gt;GO:0010556 -->
<g id="edge123" class="edge"><title>GO:0009889&#45;&gt;GO:0010556</title>
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<!-- GO:0031326 -->
<g id="node61" class="node"><title>GO:0031326</title>
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<text text-anchor="middle" x="2107" y="-563.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="2107" y="-551.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
<text text-anchor="middle" x="2107" y="-539.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009889&#45;&gt;GO:0031326 -->
<g id="edge169" class="edge"><title>GO:0009889&#45;&gt;GO:0031326</title>
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<!-- GO:0009891 -->
<g id="node78" class="node"><title>GO:0009891</title>
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<text text-anchor="middle" x="2229" y="-563.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2229" y="-551.667" style="font-family:Arial;font-size:10px;">of biosynthetic</text>
<text text-anchor="middle" x="2229" y="-539.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009889&#45;&gt;GO:0009891 -->
<g id="edge249" class="edge"><title>GO:0009889&#45;&gt;GO:0009891</title>
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<!-- GO:0009058&#45;&gt;GO:0009889 -->
<g id="edge127" class="edge"><title>GO:0009058&#45;&gt;GO:0009889</title>
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<!-- GO:0009058&#45;&gt;GO:0009059 -->
<g id="edge135" class="edge"><title>GO:0009058&#45;&gt;GO:0009059</title>
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<!-- GO:0044249 -->
<g id="node62" class="node"><title>GO:0044249</title>
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<text text-anchor="middle" x="1847" y="-637.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
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<!-- GO:0009058&#45;&gt;GO:0044249 -->
<g id="edge175" class="edge"><title>GO:0009058&#45;&gt;GO:0044249</title>
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<!-- GO:0009058&#45;&gt;GO:0009891 -->
<g id="edge263" class="edge"><title>GO:0009058&#45;&gt;GO:0009891</title>
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<!-- GO:0009059&#45;&gt;GO:0010556 -->
<g id="edge133" class="edge"><title>GO:0009059&#45;&gt;GO:0010556</title>
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<text text-anchor="middle" x="1446" y="-563.667" style="font-family:Arial;font-size:10px;">cellular macromolecule</text>
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<!-- GO:0009059&#45;&gt;GO:0034645 -->
<g id="edge187" class="edge"><title>GO:0009059&#45;&gt;GO:0034645</title>
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<!-- GO:0043284 -->
<g id="node69" class="node"><title>GO:0043284</title>
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<text text-anchor="middle" x="1147" y="-557.667" style="font-family:Arial;font-size:10px;">biopolymer biosynthetic</text>
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<!-- GO:0009059&#45;&gt;GO:0043284 -->
<g id="edge207" class="edge"><title>GO:0009059&#45;&gt;GO:0043284</title>
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<g id="edge275" class="edge"><title>GO:0009059&#45;&gt;GO:0010557</title>
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<!-- GO:0019219 -->
<g id="node54" class="node"><title>GO:0019219</title>
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<text text-anchor="middle" x="1685" y="-483.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1685" y="-471.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
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<text text-anchor="middle" x="1685" y="-435.667" style="font-family:Arial;font-size:10px;">nucleic acid</text>
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<!-- GO:0019219&#45;&gt;GO:0045449 -->
<g id="edge139" class="edge"><title>GO:0019219&#45;&gt;GO:0045449</title>
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<g id="edge313" class="edge"><title>GO:0019219&#45;&gt;GO:0045935</title>
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<g id="edge293" class="edge"><title>GO:0031323&#45;&gt;GO:0031325</title>
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<g id="edge299" class="edge"><title>GO:0050794&#45;&gt;GO:0048522</title>
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<!-- GO:0050794&#45;&gt;GO:0043067 -->
<g id="edge369" class="edge"><title>GO:0050794&#45;&gt;GO:0043067</title>
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<g id="edge149" class="edge"><title>GO:0009987&#45;&gt;GO:0050794</title>
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<g id="edge157" class="edge"><title>GO:0009987&#45;&gt;GO:0044237</title>
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<g id="edge301" class="edge"><title>GO:0009987&#45;&gt;GO:0048522</title>
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<!-- GO:0009987&#45;&gt;GO:0008219 -->
<g id="edge375" class="edge"><title>GO:0009987&#45;&gt;GO:0008219</title>
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<!-- GO:0044237&#45;&gt;GO:0031323 -->
<g id="edge153" class="edge"><title>GO:0044237&#45;&gt;GO:0031323</title>
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<!-- GO:0044237&#45;&gt;GO:0006139 -->
<g id="edge161" class="edge"><title>GO:0044237&#45;&gt;GO:0006139</title>
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<!-- GO:0044237&#45;&gt;GO:0044249 -->
<g id="edge177" class="edge"><title>GO:0044237&#45;&gt;GO:0044249</title>
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<!-- GO:0044237&#45;&gt;GO:0044260 -->
<g id="edge195" class="edge"><title>GO:0044237&#45;&gt;GO:0044260</title>
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<g id="edge303" class="edge"><title>GO:0044237&#45;&gt;GO:0031325</title>
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<g id="edge159" class="edge"><title>GO:0006139&#45;&gt;GO:0019219</title>
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<g id="edge181" class="edge"><title>GO:0006139&#45;&gt;GO:0006350</title>
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<!-- GO:0006139&#45;&gt;GO:0016070 -->
<g id="edge221" class="edge"><title>GO:0006139&#45;&gt;GO:0016070</title>
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<g id="edge163" class="edge"><title>GO:0044238&#45;&gt;GO:0006139</title>
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<g id="edge167" class="edge"><title>GO:0031326&#45;&gt;GO:0045449</title>
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<g id="edge173" class="edge"><title>GO:0044249&#45;&gt;GO:0031326</title>
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<!-- GO:0044249&#45;&gt;GO:0032774 -->
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<g id="edge307" class="edge"><title>GO:0044249&#45;&gt;GO:0031328</title>
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<g id="edge179" class="edge"><title>GO:0006350&#45;&gt;GO:0045449</title>
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<g id="edge185" class="edge"><title>GO:0034645&#45;&gt;GO:0034961</title>
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<g id="edge191" class="edge"><title>GO:0044260&#45;&gt;GO:0034645</title>
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<g id="edge243" class="edge"><title>GO:0045941&#45;&gt;GO:0045893</title>
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