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</g>
<!-- GO:0040016 -->
<g id="node9" class="node"><title>GO:0040016</title>
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<text text-anchor="middle" x="3996" y="-681.667" style="font-family:Arial;font-size:10px;">embryonic cleavage</text>
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<text text-anchor="middle" x="3996" y="-665.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="3996" y="-649.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0042985 -->
<g id="node10" class="node"><title>GO:0042985</title>
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<polygon style="fill:none;stroke:black;" points="2557,-158 2557,-212 2651,-212 2651,-158 2557,-158"/>
<text text-anchor="middle" x="2604" y="-201.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="2604" y="-189.667" style="font-family:Arial;font-size:10px;">of amyloid precursor</text>
<text text-anchor="middle" x="2604" y="-177.667" style="font-family:Arial;font-size:10px;">protein biosynthetic</text>
<text text-anchor="middle" x="2604" y="-165.667" style="font-family:Arial;font-size:10px;">process</text>
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<text text-anchor="middle" x="2604" y="-147.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2604" y="-131.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005794 -->
<g id="node11" class="node"><title>GO:0005794</title>
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<text text-anchor="middle" x="880" y="-370.667" style="font-family:Arial;font-size:10px;">Golgi apparatus</text>
<text text-anchor="middle" x="880" y="-358.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0019904 -->
<g id="node12" class="node"><title>GO:0019904</title>
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<text text-anchor="middle" x="44" y="-752.667" style="font-family:Arial;font-size:10px;">protein domain</text>
<text text-anchor="middle" x="44" y="-740.667" style="font-family:Arial;font-size:10px;">specific binding</text>
<text text-anchor="middle" x="44" y="-728.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0007346 -->
<g id="node13" class="node"><title>GO:0007346</title>
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<text text-anchor="middle" x="3582" y="-607.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="3582" y="-595.667" style="font-family:Arial;font-size:10px;">mitotic cell</text>
<text text-anchor="middle" x="3582" y="-583.667" style="font-family:Arial;font-size:10px;">cycle</text>
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<text text-anchor="middle" x="3582" y="-565.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="3582" y="-549.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0042254 -->
<g id="node14" class="node"><title>GO:0042254</title>
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<polygon style="fill:none;stroke:black;" points="3692,-597 3692,-613 3788,-613 3788,-597 3692,-597"/>
<text text-anchor="middle" x="3740" y="-602.667" style="font-family:Arial;font-size:10px;">ribosome biogenesis</text>
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<text text-anchor="middle" x="3740" y="-586.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="3692,-565 3692,-581 3788,-581 3788,-565 3692,-565"/>
<text text-anchor="middle" x="3740" y="-570.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<text text-anchor="middle" x="3740" y="-554.667" style="font-family:Arial;font-size:10px;">Pombe: ISS_only</text>
</g>
<!-- GO:0042254&#45;&gt;GO:0006364 -->
<g id="edge273" class="edge"><title>GO:0042254&#45;&gt;GO:0006364</title>
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<polygon style="fill:blue;stroke:blue;" points="3712.44,-548.137 3723,-549 3715.28,-541.74 3712.44,-548.137"/>
</g>
<!-- GO:0005730 -->
<g id="node15" class="node"><title>GO:0005730</title>
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<polygon style="fill:none;stroke:black;" points="404,-84 404,-100 486,-100 486,-84 404,-84"/>
<text text-anchor="middle" x="445" y="-89.6667" style="font-family:Arial;font-size:10px;">nucleolus</text>
<polygon style="fill:tomato;stroke:tomato;" points="404,-68 404,-84 486,-84 486,-68 404,-68"/>
<polygon style="fill:none;stroke:black;" points="404,-68 404,-84 486,-84 486,-68 404,-68"/>
<text text-anchor="middle" x="445" y="-73.6667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="404,-52 404,-68 486,-68 486,-52 404,-52"/>
<text text-anchor="middle" x="445" y="-57.6667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
<polygon style="fill:cyan;stroke:cyan;" points="404,-36 404,-52 486,-52 486,-36 404,-36"/>
<polygon style="fill:none;stroke:black;" points="404,-36 404,-52 486,-52 486,-36 404,-36"/>
<text text-anchor="middle" x="445" y="-41.6667" style="font-family:Arial;font-size:10px;">Yeast</text>
<polygon style="fill:lightblue;stroke:lightblue;" points="404,-20 404,-36 486,-36 486,-20 404,-20"/>
<polygon style="fill:none;stroke:black;" points="404,-20 404,-36 486,-36 486,-20 404,-20"/>
<text text-anchor="middle" x="445" y="-25.6667" style="font-family:Arial;font-size:10px;">Mouse</text>
<polygon style="fill:blueviolet;stroke:blueviolet;" points="404,-4 404,-20 486,-20 486,-4 404,-4"/>
<polygon style="fill:none;stroke:black;" points="404,-4 404,-20 486,-20 486,-4 404,-4"/>
<text text-anchor="middle" x="445" y="-9.66667" style="font-family:Arial;font-size:10px;">Pombe: ISS_only</text>
</g>
<!-- GO:0003700 -->
<g id="node16" class="node"><title>GO:0003700</title>
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<polygon style="fill:none;stroke:black;" points="234,-647 234,-689 298,-689 298,-647 234,-647"/>
<text text-anchor="middle" x="266" y="-678.667" style="font-family:Arial;font-size:10px;">transcription</text>
<text text-anchor="middle" x="266" y="-666.667" style="font-family:Arial;font-size:10px;">factor activity</text>
<text text-anchor="middle" x="266" y="-654.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0005634 -->
<g id="node17" class="node"><title>GO:0005634</title>
<polygon style="fill:white;stroke:white;" points="611,-398 611,-414 675,-414 675,-398 611,-398"/>
<polygon style="fill:none;stroke:black;" points="611,-398 611,-414 675,-414 675,-398 611,-398"/>
<text text-anchor="middle" x="643" y="-403.667" style="font-family:Arial;font-size:10px;">nucleus</text>
<polygon style="fill:tomato;stroke:tomato;" points="611,-382 611,-398 675,-398 675,-382 611,-382"/>
<polygon style="fill:none;stroke:black;" points="611,-382 611,-398 675,-398 675,-382 611,-382"/>
<text text-anchor="middle" x="643" y="-387.667" style="font-family:Arial;font-size:10px;">Human</text>
<polygon style="fill:gold;stroke:gold;" points="611,-366 611,-382 675,-382 675,-366 611,-366"/>
<polygon style="fill:none;stroke:black;" points="611,-366 611,-382 675,-382 675,-366 611,-366"/>
<text text-anchor="middle" x="643" y="-371.667" style="font-family:Arial;font-size:10px;">Rat</text>
<polygon style="fill:lightblue;stroke:lightblue;" points="611,-350 611,-366 675,-366 675,-350 611,-350"/>
<polygon style="fill:none;stroke:black;" points="611,-350 611,-366 675,-366 675,-350 611,-350"/>
<text text-anchor="middle" x="643" y="-355.667" style="font-family:Arial;font-size:10px;">Mouse</text>
<polygon style="fill:blueviolet;stroke:blueviolet;" points="611,-334 611,-350 675,-350 675,-334 611,-334"/>
<polygon style="fill:none;stroke:black;" points="611,-334 611,-350 675,-350 675,-334 611,-334"/>
<text text-anchor="middle" x="643" y="-339.667" style="font-family:Arial;font-size:10px;">Pombe</text>
<polygon style="fill:darkturquoise;stroke:darkturquoise;" points="611,-318 611,-334 675,-334 675,-318 611,-318"/>
<polygon style="fill:none;stroke:black;" points="611,-318 611,-334 675,-334 675,-318 611,-318"/>
<text text-anchor="middle" x="643" y="-323.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0044428 -->
<g id="node122" class="node"><title>GO:0044428</title>
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<polygon style="fill:none;stroke:black;" points="573,-257 573,-273 631,-273 631,-257 573,-257"/>
<text text-anchor="middle" x="602" y="-262.667" style="font-family:Arial;font-size:10px;">nuclear part</text>
</g>
<!-- GO:0005634&#45;&gt;GO:0044428 -->
<g id="edge473" class="edge"><title>GO:0005634&#45;&gt;GO:0044428</title>
<path style="fill:none;stroke:blue;" d="M631,-309C623,-298 613,-282 607,-273"/>
<polygon style="fill:blue;stroke:blue;" points="628.541,-311.621 637,-318 634.365,-307.738 628.541,-311.621"/>
</g>
<!-- GO:0005515 -->
<g id="node18" class="node"><title>GO:0005515</title>
<polygon style="fill:white;stroke:white;" points="114,-840 114,-856 184,-856 184,-840 114,-840"/>
<polygon style="fill:none;stroke:black;" points="114,-840 114,-856 184,-856 184,-840 114,-840"/>
<text text-anchor="middle" x="149" y="-845.667" style="font-family:Arial;font-size:10px;">protein binding</text>
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<polygon style="fill:none;stroke:black;" points="114,-824 114,-840 184,-840 184,-824 114,-824"/>
<text text-anchor="middle" x="149" y="-829.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="114,-808 114,-824 184,-824 184,-808 114,-808"/>
<text text-anchor="middle" x="149" y="-813.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="114,-792 114,-808 184,-808 184,-792 114,-792"/>
<text text-anchor="middle" x="149" y="-797.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0019904 -->
<g id="edge449" class="edge"><title>GO:0005515&#45;&gt;GO:0019904</title>
<path style="fill:none;stroke:gray;" d="M125,-787C112,-779 95,-770 80,-762"/>
<polygon style="fill:gray;stroke:gray;" points="123.559,-790.203 134,-792 126.958,-784.084 123.559,-790.203"/>
</g>
<!-- GO:0008092 -->
<g id="node134" class="node"><title>GO:0008092</title>
<polygon style="fill:white;stroke:white;" points="114,-727 114,-757 184,-757 184,-727 114,-727"/>
<polygon style="fill:none;stroke:black;" points="114,-727 114,-757 184,-757 184,-727 114,-727"/>
<text text-anchor="middle" x="149" y="-746.667" style="font-family:Arial;font-size:10px;">cytoskeletal</text>
<text text-anchor="middle" x="149" y="-734.667" style="font-family:Arial;font-size:10px;">protein binding</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0008092 -->
<g id="edge521" class="edge"><title>GO:0005515&#45;&gt;GO:0008092</title>
<path style="fill:none;stroke:gray;" d="M149,-782C149,-774 149,-764 149,-757"/>
<polygon style="fill:gray;stroke:gray;" points="145.5,-782 149,-792 152.5,-782 145.5,-782"/>
</g>
<!-- GO:0030686 -->
<g id="node19" class="node"><title>GO:0030686</title>
<polygon style="fill:cyan;stroke:cyan;" points="1008,-351 1008,-381 1088,-381 1088,-351 1008,-351"/>
<polygon style="fill:none;stroke:black;" points="1008,-351 1008,-381 1088,-381 1088,-351 1008,-351"/>
<text text-anchor="middle" x="1048" y="-370.667" style="font-family:Arial;font-size:10px;">90S preribosome</text>
<text text-anchor="middle" x="1048" y="-358.667" style="font-family:Arial;font-size:10px;">Yeast</text>
</g>
<!-- GO:0007155 -->
<g id="node20" class="node"><title>GO:0007155</title>
<polygon style="fill:white;stroke:white;" points="3993,-750 3993,-766 4059,-766 4059,-750 3993,-750"/>
<polygon style="fill:none;stroke:black;" points="3993,-750 3993,-766 4059,-766 4059,-750 3993,-750"/>
<text text-anchor="middle" x="4026" y="-755.667" style="font-family:Arial;font-size:10px;">cell adhesion</text>
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<polygon style="fill:none;stroke:black;" points="3993,-734 3993,-750 4059,-750 4059,-734 3993,-734"/>
<text text-anchor="middle" x="4026" y="-739.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="3993,-718 3993,-734 4059,-734 4059,-718 3993,-718"/>
<text text-anchor="middle" x="4026" y="-723.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0048156 -->
<g id="node21" class="node"><title>GO:0048156</title>
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<polygon style="fill:none;stroke:black;" points="123,-647 123,-689 175,-689 175,-647 123,-647"/>
<text text-anchor="middle" x="149" y="-678.667" style="font-family:Arial;font-size:10px;">tau protein</text>
<text text-anchor="middle" x="149" y="-666.667" style="font-family:Arial;font-size:10px;">binding</text>
<text text-anchor="middle" x="149" y="-654.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0005737 -->
<g id="node22" class="node"><title>GO:0005737</title>
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<polygon style="fill:none;stroke:black;" points="884,-589 884,-605 936,-605 936,-589 884,-589"/>
<text text-anchor="middle" x="910" y="-594.667" style="font-family:Arial;font-size:10px;">cytoplasm</text>
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<polygon style="fill:none;stroke:black;" points="884,-573 884,-589 936,-589 936,-573 884,-573"/>
<text text-anchor="middle" x="910" y="-578.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<polygon style="fill:none;stroke:black;" points="884,-557 884,-573 936,-573 936,-557 884,-557"/>
<text text-anchor="middle" x="910" y="-562.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0044444 -->
<g id="node76" class="node"><title>GO:0044444</title>
<polygon style="fill:white;stroke:white;" points="903,-464 903,-494 961,-494 961,-464 903,-464"/>
<polygon style="fill:none;stroke:black;" points="903,-464 903,-494 961,-494 961,-464 903,-464"/>
<text text-anchor="middle" x="932" y="-483.667" style="font-family:Arial;font-size:10px;">cytoplasmic</text>
<text text-anchor="middle" x="932" y="-471.667" style="font-family:Arial;font-size:10px;">part</text>
</g>
<!-- GO:0005737&#45;&gt;GO:0044444 -->
<g id="edge245" class="edge"><title>GO:0005737&#45;&gt;GO:0044444</title>
<path style="fill:none;stroke:blue;" d="M915,-547C919,-531 925,-509 928,-494"/>
<polygon style="fill:blue;stroke:blue;" points="911.521,-546.416 912,-557 918.226,-548.427 911.521,-546.416"/>
</g>
<!-- GO:0005925 -->
<g id="node23" class="node"><title>GO:0005925</title>
<polygon style="fill:white;stroke:white;" points="1185,-60 1185,-76 1253,-76 1253,-60 1185,-60"/>
<polygon style="fill:none;stroke:black;" points="1185,-60 1185,-76 1253,-76 1253,-60 1185,-60"/>
<text text-anchor="middle" x="1219" y="-65.6667" style="font-family:Arial;font-size:10px;">focal adhesion</text>
<polygon style="fill:tomato;stroke:tomato;" points="1185,-44 1185,-60 1253,-60 1253,-44 1185,-44"/>
<polygon style="fill:none;stroke:black;" points="1185,-44 1185,-60 1253,-60 1253,-44 1185,-44"/>
<text text-anchor="middle" x="1219" y="-49.6667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="1185,-28 1185,-44 1253,-44 1253,-28 1185,-28"/>
<text text-anchor="middle" x="1219" y="-33.6667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0010557 -->
<g id="node24" class="node"><title>GO:0010557</title>
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<polygon style="fill:none;stroke:black;" points="2034,-452 2034,-506 2118,-506 2118,-452 2034,-452"/>
<text text-anchor="middle" x="2076" y="-495.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2076" y="-483.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
<text text-anchor="middle" x="2076" y="-471.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2076" y="-459.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0010557&#45;&gt;GO:0045941 -->
<g id="edge3" class="edge"><title>GO:0010557&#45;&gt;GO:0045941</title>
<path style="fill:none;stroke:gray;" d="M2076,-442C2078,-408 2081,-356 2095,-314 2110,-266 2141,-217 2160,-190"/>
<polygon style="fill:gray;stroke:gray;" points="2072.5,-442 2076,-452 2079.5,-442 2072.5,-442"/>
</g>
<!-- GO:0009891 -->
<g id="node25" class="node"><title>GO:0009891</title>
<polygon style="fill:white;stroke:white;" points="2714,-560 2714,-602 2798,-602 2798,-560 2714,-560"/>
<polygon style="fill:none;stroke:black;" points="2714,-560 2714,-602 2798,-602 2798,-560 2714,-560"/>
<text text-anchor="middle" x="2756" y="-591.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2756" y="-579.667" style="font-family:Arial;font-size:10px;">of biosynthetic</text>
<text text-anchor="middle" x="2756" y="-567.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0009891&#45;&gt;GO:0010557 -->
<g id="edge5" class="edge"><title>GO:0009891&#45;&gt;GO:0010557</title>
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<g id="edge85" class="edge"><title>GO:0009891&#45;&gt;GO:0031328</title>
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<g id="edge7" class="edge"><title>GO:0009889&#45;&gt;GO:0009891</title>
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<g id="edge43" class="edge"><title>GO:0009889&#45;&gt;GO:0010556</title>
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<g id="edge121" class="edge"><title>GO:0009889&#45;&gt;GO:0031326</title>
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<!-- GO:0009889&#45;&gt;GO:0009890 -->
<g id="edge323" class="edge"><title>GO:0009889&#45;&gt;GO:0009890</title>
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<g id="edge9" class="edge"><title>GO:0019222&#45;&gt;GO:0009889</title>
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<!-- GO:0019222&#45;&gt;GO:0009893 -->
<g id="edge29" class="edge"><title>GO:0019222&#45;&gt;GO:0009893</title>
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<text text-anchor="middle" x="2149" y="-666.667" style="font-family:Arial;font-size:10px;">macromolecule</text>
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<g id="edge47" class="edge"><title>GO:0019222&#45;&gt;GO:0060255</title>
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<g id="edge93" class="edge"><title>GO:0019222&#45;&gt;GO:0031323</title>
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<g id="edge327" class="edge"><title>GO:0019222&#45;&gt;GO:0009892</title>
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<g id="edge11" class="edge"><title>GO:0050789&#45;&gt;GO:0019222</title>
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<g id="edge33" class="edge"><title>GO:0050789&#45;&gt;GO:0048518</title>
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<!-- GO:0050789&#45;&gt;GO:0050794 -->
<g id="edge97" class="edge"><title>GO:0050789&#45;&gt;GO:0050794</title>
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<g id="edge331" class="edge"><title>GO:0050789&#45;&gt;GO:0048519</title>
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<g id="edge13" class="edge"><title>GO:0065007&#45;&gt;GO:0050789</title>
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<!-- GO:0008152&#45;&gt;GO:0009058 -->
<g id="edge25" class="edge"><title>GO:0008152&#45;&gt;GO:0009058</title>
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<g id="edge37" class="edge"><title>GO:0008152&#45;&gt;GO:0009893</title>
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<g id="edge51" class="edge"><title>GO:0008152&#45;&gt;GO:0043170</title>
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<g id="edge105" class="edge"><title>GO:0008152&#45;&gt;GO:0044237</title>
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<g id="edge55" class="edge"><title>GO:0009058&#45;&gt;GO:0009059</title>
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<g id="edge27" class="edge"><title>GO:0009893&#45;&gt;GO:0009891</title>
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<text text-anchor="middle" x="1955" y="-591.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="1955" y="-579.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
<text text-anchor="middle" x="1955" y="-567.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0009893&#45;&gt;GO:0010604 -->
<g id="edge61" class="edge"><title>GO:0009893&#45;&gt;GO:0010604</title>
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<!-- GO:0009893&#45;&gt;GO:0031325 -->
<g id="edge89" class="edge"><title>GO:0009893&#45;&gt;GO:0031325</title>
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<g id="edge31" class="edge"><title>GO:0048518&#45;&gt;GO:0009893</title>
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<g id="edge111" class="edge"><title>GO:0048518&#45;&gt;GO:0048522</title>
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<g id="edge41" class="edge"><title>GO:0010556&#45;&gt;GO:0010557</title>
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<!-- GO:0045449 -->
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<!-- GO:0010556&#45;&gt;GO:0045449 -->
<g id="edge137" class="edge"><title>GO:0010556&#45;&gt;GO:0045449</title>
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<!-- GO:0010556&#45;&gt;GO:0010558 -->
<g id="edge339" class="edge"><title>GO:0010556&#45;&gt;GO:0010558</title>
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<!-- GO:0010559 -->
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<text text-anchor="middle" x="2623" y="-382.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<text text-anchor="middle" x="2623" y="-358.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
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<g id="edge353" class="edge"><title>GO:0010556&#45;&gt;GO:0010559</title>
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<!-- GO:0060255&#45;&gt;GO:0010556 -->
<g id="edge45" class="edge"><title>GO:0060255&#45;&gt;GO:0010556</title>
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<!-- GO:0060255&#45;&gt;GO:0010604 -->
<g id="edge63" class="edge"><title>GO:0060255&#45;&gt;GO:0010604</title>
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<!-- GO:0010468 -->
<g id="node40" class="node"><title>GO:0010468</title>
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<text text-anchor="middle" x="1442" y="-370.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0060255&#45;&gt;GO:0010468 -->
<g id="edge73" class="edge"><title>GO:0060255&#45;&gt;GO:0010468</title>
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<!-- GO:0010605 -->
<g id="node100" class="node"><title>GO:0010605</title>
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<text text-anchor="middle" x="2377" y="-591.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="2377" y="-579.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
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<!-- GO:0060255&#45;&gt;GO:0010605 -->
<g id="edge345" class="edge"><title>GO:0060255&#45;&gt;GO:0010605</title>
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<!-- GO:0051246 -->
<g id="node109" class="node"><title>GO:0051246</title>
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<text text-anchor="middle" x="1612" y="-489.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0060255&#45;&gt;GO:0051246 -->
<g id="edge401" class="edge"><title>GO:0060255&#45;&gt;GO:0051246</title>
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<!-- GO:0043170&#45;&gt;GO:0060255 -->
<g id="edge49" class="edge"><title>GO:0043170&#45;&gt;GO:0060255</title>
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<!-- GO:0043170&#45;&gt;GO:0009059 -->
<g id="edge57" class="edge"><title>GO:0043170&#45;&gt;GO:0009059</title>
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<!-- GO:0043170&#45;&gt;GO:0010604 -->
<g id="edge65" class="edge"><title>GO:0043170&#45;&gt;GO:0010604</title>
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<!-- GO:0010467 -->
<g id="node41" class="node"><title>GO:0010467</title>
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<!-- GO:0043170&#45;&gt;GO:0010467 -->
<g id="edge77" class="edge"><title>GO:0043170&#45;&gt;GO:0010467</title>
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<!-- GO:0044260 -->
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<!-- GO:0043170&#45;&gt;GO:0044260 -->
<g id="edge167" class="edge"><title>GO:0043170&#45;&gt;GO:0044260</title>
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<!-- GO:0043170&#45;&gt;GO:0043283 -->
<g id="edge175" class="edge"><title>GO:0043170&#45;&gt;GO:0043283</title>
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<!-- GO:0043170&#45;&gt;GO:0010605 -->
<g id="edge347" class="edge"><title>GO:0043170&#45;&gt;GO:0010605</title>
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<g id="edge67" class="edge"><title>GO:0009059&#45;&gt;GO:0010557</title>
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<g id="edge53" class="edge"><title>GO:0009059&#45;&gt;GO:0010556</title>
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<!-- GO:0009059&#45;&gt;GO:0034645 -->
<g id="edge161" class="edge"><title>GO:0009059&#45;&gt;GO:0034645</title>
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<!-- GO:0043284 -->
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<!-- GO:0009059&#45;&gt;GO:0043284 -->
<g id="edge181" class="edge"><title>GO:0009059&#45;&gt;GO:0043284</title>
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<g id="edge349" class="edge"><title>GO:0009059&#45;&gt;GO:0010558</title>
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<g id="edge59" class="edge"><title>GO:0010604&#45;&gt;GO:0010557</title>
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<!-- GO:0010604&#45;&gt;GO:0010628 -->
<g id="edge79" class="edge"><title>GO:0010604&#45;&gt;GO:0010628</title>
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<g id="edge71" class="edge"><title>GO:0010468&#45;&gt;GO:0010628</title>
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<g id="edge135" class="edge"><title>GO:0010468&#45;&gt;GO:0045449</title>
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<g id="edge81" class="edge"><title>GO:0010467&#45;&gt;GO:0010628</title>
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<g id="edge75" class="edge"><title>GO:0010467&#45;&gt;GO:0010468</title>
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<!-- GO:0010467&#45;&gt;GO:0006350 -->
<g id="edge185" class="edge"><title>GO:0010467&#45;&gt;GO:0006350</title>
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<text text-anchor="middle" x="1635" y="-363.667" style="font-family:Arial;font-size:10px;">RNA processing</text>
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<!-- GO:0010467&#45;&gt;GO:0006396 -->
<g id="edge271" class="edge"><title>GO:0010467&#45;&gt;GO:0006396</title>
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<g id="edge83" class="edge"><title>GO:0031328&#45;&gt;GO:0045941</title>
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<g id="edge87" class="edge"><title>GO:0031325&#45;&gt;GO:0031328</title>
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<text text-anchor="middle" x="2441" y="-394.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2441" y="-382.667" style="font-family:Arial;font-size:10px;">of nucleobase,</text>
<text text-anchor="middle" x="2441" y="-370.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
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<!-- GO:0031325&#45;&gt;GO:0045935 -->
<g id="edge191" class="edge"><title>GO:0031325&#45;&gt;GO:0045935</title>
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<g id="edge91" class="edge"><title>GO:0031323&#45;&gt;GO:0031325</title>
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<g id="edge123" class="edge"><title>GO:0031323&#45;&gt;GO:0031326</title>
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<text text-anchor="middle" x="2347" y="-507.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<g id="edge141" class="edge"><title>GO:0031323&#45;&gt;GO:0019219</title>
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<text text-anchor="middle" x="3393" y="-591.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="3393" y="-579.667" style="font-family:Arial;font-size:10px;">of cellular</text>
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<!-- GO:0031323&#45;&gt;GO:0031324 -->
<g id="edge373" class="edge"><title>GO:0031323&#45;&gt;GO:0031324</title>
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<!-- GO:0032268 -->
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<text text-anchor="middle" x="1874" y="-376.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="1874" y="-364.667" style="font-family:Arial;font-size:10px;">cellular protein</text>
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<!-- GO:0031323&#45;&gt;GO:0032268 -->
<g id="edge397" class="edge"><title>GO:0031323&#45;&gt;GO:0032268</title>
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<g id="edge95" class="edge"><title>GO:0050794&#45;&gt;GO:0031323</title>
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<g id="edge113" class="edge"><title>GO:0050794&#45;&gt;GO:0048522</title>
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<text text-anchor="middle" x="3433" y="-666.667" style="font-family:Arial;font-size:10px;">of cellular</text>
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<!-- GO:0050794&#45;&gt;GO:0048523 -->
<g id="edge379" class="edge"><title>GO:0050794&#45;&gt;GO:0048523</title>
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<text text-anchor="middle" x="3539" y="-672.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0050794&#45;&gt;GO:0051726 -->
<g id="edge457" class="edge"><title>GO:0050794&#45;&gt;GO:0051726</title>
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<!-- GO:0009987&#45;&gt;GO:0007155 -->
<g id="edge513" class="edge"><title>GO:0009987&#45;&gt;GO:0007155</title>
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<!-- GO:0009987&#45;&gt;GO:0050794 -->
<g id="edge99" class="edge"><title>GO:0009987&#45;&gt;GO:0050794</title>
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<g id="edge107" class="edge"><title>GO:0009987&#45;&gt;GO:0044237</title>
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<!-- GO:0009987&#45;&gt;GO:0048522 -->
<g id="edge115" class="edge"><title>GO:0009987&#45;&gt;GO:0048522</title>
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<!-- GO:0009987&#45;&gt;GO:0016043 -->
<g id="edge279" class="edge"><title>GO:0009987&#45;&gt;GO:0016043</title>
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<!-- GO:0009987&#45;&gt;GO:0051301 -->
<g id="edge301" class="edge"><title>GO:0009987&#45;&gt;GO:0051301</title>
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<g id="edge381" class="edge"><title>GO:0009987&#45;&gt;GO:0048523</title>
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<g id="edge461" class="edge"><title>GO:0009987&#45;&gt;GO:0007049</title>
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<g id="edge117" class="edge"><title>GO:0044237&#45;&gt;GO:0031325</title>
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<g id="edge103" class="edge"><title>GO:0044237&#45;&gt;GO:0031323</title>
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<g id="edge129" class="edge"><title>GO:0044237&#45;&gt;GO:0044249</title>
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<g id="edge145" class="edge"><title>GO:0044237&#45;&gt;GO:0006139</title>
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<g id="edge169" class="edge"><title>GO:0044237&#45;&gt;GO:0044260</title>
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<g id="edge109" class="edge"><title>GO:0048522&#45;&gt;GO:0031325</title>
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<g id="edge119" class="edge"><title>GO:0031326&#45;&gt;GO:0031328</title>
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<text text-anchor="middle" x="658" y="-573.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<!-- GO:0043226&#45;&gt;GO:0043229 -->
<g id="edge227" class="edge"><title>GO:0043226&#45;&gt;GO:0043229</title>
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<!-- GO:0043228 -->
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<text text-anchor="middle" x="541" y="-573.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<!-- GO:0043226&#45;&gt;GO:0043228 -->
<g id="edge237" class="edge"><title>GO:0043226&#45;&gt;GO:0043228</title>
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<g id="node117" class="node"><title>GO:0043227</title>
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<!-- GO:0043226&#45;&gt;GO:0043227 -->
<g id="edge443" class="edge"><title>GO:0043226&#45;&gt;GO:0043227</title>
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<text text-anchor="middle" x="859" y="-672.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="859" y="-660.667" style="font-family:Arial;font-size:10px;">part</text>
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<!-- GO:0044424&#45;&gt;GO:0005737 -->
<g id="edge247" class="edge"><title>GO:0044424&#45;&gt;GO:0005737</title>
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<!-- GO:0044424&#45;&gt;GO:0044446 -->
<g id="edge211" class="edge"><title>GO:0044424&#45;&gt;GO:0044446</title>
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<!-- GO:0044424&#45;&gt;GO:0043229 -->
<g id="edge229" class="edge"><title>GO:0044424&#45;&gt;GO:0043229</title>
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<!-- GO:0044424&#45;&gt;GO:0044444 -->
<g id="edge243" class="edge"><title>GO:0044424&#45;&gt;GO:0044444</title>
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<!-- GO:0030529 -->
<g id="node131" class="node"><title>GO:0030529</title>
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<polygon style="fill:none;stroke:black;" points="1008,-566 1008,-596 1088,-596 1088,-566 1008,-566"/>
<text text-anchor="middle" x="1048" y="-585.667" style="font-family:Arial;font-size:10px;">ribonucleoprotein</text>
<text text-anchor="middle" x="1048" y="-573.667" style="font-family:Arial;font-size:10px;">complex</text>
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<!-- GO:0044424&#45;&gt;GO:0030529 -->
<g id="edge511" class="edge"><title>GO:0044424&#45;&gt;GO:0030529</title>
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<!-- GO:0044464&#45;&gt;GO:0044424 -->
<g id="edge213" class="edge"><title>GO:0044464&#45;&gt;GO:0044424</title>
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<g id="node71" class="node"><title>GO:0005622</title>
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<polygon style="fill:none;stroke:black;" points="952,-734 952,-750 1008,-750 1008,-734 952,-734"/>
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</g>
<!-- GO:0044464&#45;&gt;GO:0005622 -->
<g id="edge223" class="edge"><title>GO:0044464&#45;&gt;GO:0005622</title>
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<!-- GO:0044425 -->
<g id="node87" class="node"><title>GO:0044425</title>
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<text text-anchor="middle" x="1052" y="-665.667" style="font-family:Arial;font-size:10px;">membrane part</text>
</g>
<!-- GO:0044464&#45;&gt;GO:0044425 -->
<g id="edge289" class="edge"><title>GO:0044464&#45;&gt;GO:0044425</title>
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<!-- GO:0016020 -->
<g id="node88" class="node"><title>GO:0016020</title>
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<polygon style="fill:none;stroke:black;" points="1080,-734 1080,-750 1132,-750 1132,-734 1080,-734"/>
<text text-anchor="middle" x="1106" y="-739.667" style="font-family:Arial;font-size:10px;">membrane</text>
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<!-- GO:0044464&#45;&gt;GO:0016020 -->
<g id="edge293" class="edge"><title>GO:0044464&#45;&gt;GO:0016020</title>
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<!-- GO:0005623&#45;&gt;GO:0044464 -->
<g id="edge217" class="edge"><title>GO:0005623&#45;&gt;GO:0044464</title>
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<!-- GO:0005622&#45;&gt;GO:0044424 -->
<g id="edge221" class="edge"><title>GO:0005622&#45;&gt;GO:0044424</title>
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<!-- GO:0043229&#45;&gt;GO:0044446 -->
<g id="edge225" class="edge"><title>GO:0043229&#45;&gt;GO:0044446</title>
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<!-- GO:0043232 -->
<g id="node74" class="node"><title>GO:0043232</title>
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<polygon style="fill:none;stroke:black;" points="482,-458 482,-500 592,-500 592,-458 482,-458"/>
<text text-anchor="middle" x="537" y="-489.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="537" y="-477.667" style="font-family:Arial;font-size:10px;">non&#45;membrane&#45;bounded</text>
<text text-anchor="middle" x="537" y="-465.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<!-- GO:0043229&#45;&gt;GO:0043232 -->
<g id="edge239" class="edge"><title>GO:0043229&#45;&gt;GO:0043232</title>
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<polygon style="fill:gray;stroke:gray;" points="632.454,-561.404 642,-566 637.404,-556.454 632.454,-561.404"/>
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<!-- GO:0043231 -->
<g id="node116" class="node"><title>GO:0043231</title>
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<polygon style="fill:none;stroke:black;" points="724,-458 724,-500 816,-500 816,-458 724,-458"/>
<text text-anchor="middle" x="770" y="-489.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="770" y="-477.667" style="font-family:Arial;font-size:10px;">membrane&#45;bounded</text>
<text text-anchor="middle" x="770" y="-465.667" style="font-family:Arial;font-size:10px;">organelle</text>
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<!-- GO:0043229&#45;&gt;GO:0043231 -->
<g id="edge445" class="edge"><title>GO:0043229&#45;&gt;GO:0043231</title>
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<polygon style="fill:gray;stroke:gray;" points="680.221,-556.781 675,-566 684.831,-562.049 680.221,-556.781"/>
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<g id="node73" class="node"><title>GO:0005856</title>
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<polygon style="fill:none;stroke:black;" points="709,-358 709,-374 771,-374 771,-358 709,-358"/>
<text text-anchor="middle" x="740" y="-363.667" style="font-family:Arial;font-size:10px;">cytoskeleton</text>
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<!-- GO:0005856&#45;&gt;GO:0044430 -->
<g id="edge231" class="edge"><title>GO:0005856&#45;&gt;GO:0044430</title>
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<!-- GO:0015630 -->
<g id="node77" class="node"><title>GO:0015630</title>
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<polygon style="fill:none;stroke:black;" points="682,-250 682,-280 744,-280 744,-250 682,-250"/>
<text text-anchor="middle" x="713" y="-269.667" style="font-family:Arial;font-size:10px;">microtubule</text>
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<!-- GO:0005856&#45;&gt;GO:0015630 -->
<g id="edge251" class="edge"><title>GO:0005856&#45;&gt;GO:0015630</title>
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<!-- GO:0043232&#45;&gt;GO:0005813 -->
<g id="edge253" class="edge"><title>GO:0043232&#45;&gt;GO:0005813</title>
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<!-- GO:0043232&#45;&gt;GO:0005730 -->
<g id="edge467" class="edge"><title>GO:0043232&#45;&gt;GO:0005730</title>
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<g id="edge233" class="edge"><title>GO:0043232&#45;&gt;GO:0005856</title>
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<!-- GO:0043228&#45;&gt;GO:0043232 -->
<g id="edge235" class="edge"><title>GO:0043228&#45;&gt;GO:0043232</title>
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<!-- GO:0044444&#45;&gt;GO:0005794 -->
<g id="edge447" class="edge"><title>GO:0044444&#45;&gt;GO:0005794</title>
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<!-- GO:0044444&#45;&gt;GO:0005815 -->
<g id="edge241" class="edge"><title>GO:0044444&#45;&gt;GO:0005815</title>
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<!-- GO:0015630&#45;&gt;GO:0005815 -->
<g id="edge249" class="edge"><title>GO:0015630&#45;&gt;GO:0005815</title>
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<g id="node78" class="node"><title>GO:0016072</title>
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<text text-anchor="middle" x="2347" y="-269.667" style="font-family:Arial;font-size:10px;">rRNA metabolic</text>
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<!-- GO:0016072&#45;&gt;GO:0006364 -->
<g id="edge255" class="edge"><title>GO:0016072&#45;&gt;GO:0006364</title>
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<!-- GO:0034660 -->
<g id="node79" class="node"><title>GO:0034660</title>
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<text text-anchor="middle" x="2323" y="-370.667" style="font-family:Arial;font-size:10px;">ncRNA metabolic</text>
<text text-anchor="middle" x="2323" y="-358.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0034660&#45;&gt;GO:0016072 -->
<g id="edge257" class="edge"><title>GO:0034660&#45;&gt;GO:0016072</title>
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<!-- GO:0016070&#45;&gt;GO:0034660 -->
<g id="edge259" class="edge"><title>GO:0016070&#45;&gt;GO:0034660</title>
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<!-- GO:0016070&#45;&gt;GO:0006396 -->
<g id="edge269" class="edge"><title>GO:0016070&#45;&gt;GO:0006396</title>
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<!-- GO:0034470 -->
<g id="node81" class="node"><title>GO:0034470</title>
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<text text-anchor="middle" x="1734" y="-262.667" style="font-family:Arial;font-size:10px;">ncRNA processing</text>
</g>
<!-- GO:0034470&#45;&gt;GO:0006364 -->
<g id="edge265" class="edge"><title>GO:0034470&#45;&gt;GO:0006364</title>
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<!-- GO:0006396&#45;&gt;GO:0034470 -->
<g id="edge267" class="edge"><title>GO:0006396&#45;&gt;GO:0034470</title>
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<!-- GO:0006996 -->
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<text text-anchor="middle" x="3740" y="-665.667" style="font-family:Arial;font-size:10px;">organelle organization</text>
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<!-- GO:0006996&#45;&gt;GO:0042254 -->
<g id="edge275" class="edge"><title>GO:0006996&#45;&gt;GO:0042254</title>
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<g id="edge277" class="edge"><title>GO:0016043&#45;&gt;GO:0006996</title>
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<!-- GO:0022613 -->
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<text text-anchor="middle" x="3870" y="-678.667" style="font-family:Arial;font-size:10px;">ribonucleoprotein</text>
<text text-anchor="middle" x="3870" y="-666.667" style="font-family:Arial;font-size:10px;">complex biogenesis</text>
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<!-- GO:0016043&#45;&gt;GO:0022613 -->
<g id="edge283" class="edge"><title>GO:0016043&#45;&gt;GO:0022613</title>
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<!-- GO:0022613&#45;&gt;GO:0042254 -->
<g id="edge281" class="edge"><title>GO:0022613&#45;&gt;GO:0042254</title>
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<polygon style="fill:none;stroke:black;" points="1122,-566 1122,-596 1208,-596 1208,-566 1122,-566"/>
<text text-anchor="middle" x="1165" y="-585.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
<text text-anchor="middle" x="1165" y="-573.667" style="font-family:Arial;font-size:10px;">part</text>
</g>
<!-- GO:0044459&#45;&gt;GO:0030054 -->
<g id="edge285" class="edge"><title>GO:0044459&#45;&gt;GO:0030054</title>
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<polygon style="fill:gray;stroke:gray;" points="1189.22,-556.781 1184,-566 1193.83,-562.049 1189.22,-556.781"/>
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<!-- GO:0016323 -->
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<polygon style="fill:none;stroke:black;" points="1117,-464 1117,-494 1203,-494 1203,-464 1117,-464"/>
<text text-anchor="middle" x="1160" y="-483.667" style="font-family:Arial;font-size:10px;">basolateral</text>
<text text-anchor="middle" x="1160" y="-471.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
</g>
<!-- GO:0044459&#45;&gt;GO:0016323 -->
<g id="edge537" class="edge"><title>GO:0044459&#45;&gt;GO:0016323</title>
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<!-- GO:0044425&#45;&gt;GO:0044459 -->
<g id="edge287" class="edge"><title>GO:0044425&#45;&gt;GO:0044459</title>
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<!-- GO:0016020&#45;&gt;GO:0044425 -->
<g id="edge291" class="edge"><title>GO:0016020&#45;&gt;GO:0044425</title>
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<!-- GO:0005886 -->
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<text text-anchor="middle" x="1165" y="-665.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
</g>
<!-- GO:0016020&#45;&gt;GO:0005886 -->
<g id="edge297" class="edge"><title>GO:0016020&#45;&gt;GO:0005886</title>
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<g id="edge295" class="edge"><title>GO:0005886&#45;&gt;GO:0044459</title>
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<!-- GO:0051301&#45;&gt;GO:0040016 -->
<g id="edge299" class="edge"><title>GO:0051301&#45;&gt;GO:0040016</title>
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<polygon style="fill:gray;stroke:gray;" points="3804.9,-725.2 3799,-734 3809.1,-730.8 3804.9,-725.2"/>
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<!-- GO:0009790 -->
<g id="node91" class="node"><title>GO:0009790</title>
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<polygon style="fill:none;stroke:black;" points="3851,-734 3851,-750 3959,-750 3959,-734 3851,-734"/>
<text text-anchor="middle" x="3905" y="-739.667" style="font-family:Arial;font-size:10px;">embryonic development</text>
</g>
<!-- GO:0009790&#45;&gt;GO:0040016 -->
<g id="edge303" class="edge"><title>GO:0009790&#45;&gt;GO:0040016</title>
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<polygon style="fill:blue;stroke:blue;" points="3924.62,-725.732 3918,-734 3928.34,-731.668 3924.62,-725.732"/>
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<!-- GO:0032502&#45;&gt;GO:0009790 -->
<g id="edge305" class="edge"><title>GO:0032502&#45;&gt;GO:0009790</title>
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</g>
<!-- GO:0007275 -->
<g id="node93" class="node"><title>GO:0007275</title>
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<polygon style="fill:none;stroke:black;" points="3644,-809 3644,-839 3754,-839 3754,-809 3644,-809"/>
<text text-anchor="middle" x="3699" y="-828.667" style="font-family:Arial;font-size:10px;">multicellular</text>
<text text-anchor="middle" x="3699" y="-816.667" style="font-family:Arial;font-size:10px;">organismal development</text>
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<!-- GO:0032502&#45;&gt;GO:0007275 -->
<g id="edge315" class="edge"><title>GO:0032502&#45;&gt;GO:0007275</title>
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<!-- GO:0007275&#45;&gt;GO:0009790 -->
<g id="edge309" class="edge"><title>GO:0007275&#45;&gt;GO:0009790</title>
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<polygon style="fill:blue;stroke:blue;" points="3744.72,-801.74 3737,-809 3747.56,-808.137 3744.72,-801.74"/>
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<!-- GO:0032501&#45;&gt;GO:0007275 -->
<g id="edge311" class="edge"><title>GO:0032501&#45;&gt;GO:0007275</title>
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<polygon style="fill:gray;stroke:gray;" points="3695.5,-872 3699,-882 3702.5,-872 3695.5,-872"/>
</g>
<!-- GO:0010561 -->
<g id="node95" class="node"><title>GO:0010561</title>
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<polygon style="fill:none;stroke:black;" points="2500,-238 2500,-292 2586,-292 2586,-238 2500,-238"/>
<text text-anchor="middle" x="2543" y="-281.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="2543" y="-269.667" style="font-family:Arial;font-size:10px;">of glycoprotein</text>
<text text-anchor="middle" x="2543" y="-257.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2543" y="-245.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0010561&#45;&gt;GO:0042985 -->
<g id="edge317" class="edge"><title>GO:0010561&#45;&gt;GO:0042985</title>
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<polygon style="fill:gray;stroke:gray;" points="2567.2,-227.9 2564,-238 2572.8,-232.1 2567.2,-227.9"/>
</g>
<!-- GO:0010558&#45;&gt;GO:0010561 -->
<g id="edge319" class="edge"><title>GO:0010558&#45;&gt;GO:0010561</title>
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<polygon style="fill:gray;stroke:gray;" points="2508.53,-441.508 2510,-452 2515.39,-442.881 2508.53,-441.508"/>
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<!-- GO:0009890&#45;&gt;GO:0010558 -->
<g id="edge321" class="edge"><title>GO:0009890&#45;&gt;GO:0010558</title>
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<!-- GO:0009890&#45;&gt;GO:0031327 -->
<g id="edge367" class="edge"><title>GO:0009890&#45;&gt;GO:0031327</title>
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<!-- GO:0009892&#45;&gt;GO:0009890 -->
<g id="edge325" class="edge"><title>GO:0009892&#45;&gt;GO:0009890</title>
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<polygon style="fill:gray;stroke:gray;" points="2961.9,-643.8 2972,-647 2966.1,-638.2 2961.9,-643.8"/>
</g>
<!-- GO:0009892&#45;&gt;GO:0010605 -->
<g id="edge343" class="edge"><title>GO:0009892&#45;&gt;GO:0010605</title>
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<!-- GO:0009892&#45;&gt;GO:0031324 -->
<g id="edge371" class="edge"><title>GO:0009892&#45;&gt;GO:0031324</title>
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<!-- GO:0048519&#45;&gt;GO:0009892 -->
<g id="edge329" class="edge"><title>GO:0048519&#45;&gt;GO:0009892</title>
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<!-- GO:0048519&#45;&gt;GO:0048523 -->
<g id="edge377" class="edge"><title>GO:0048519&#45;&gt;GO:0048523</title>
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<polygon style="fill:gray;stroke:gray;" points="3342.04,-713.084 3335,-721 3345.44,-719.203 3342.04,-713.084"/>
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<!-- GO:0010605&#45;&gt;GO:0010558 -->
<g id="edge341" class="edge"><title>GO:0010605&#45;&gt;GO:0010558</title>
<path style="fill:none;stroke:gray;" d="M2412,-553C2430,-538 2453,-521 2471,-506"/>
<polygon style="fill:gray;stroke:gray;" points="2409.22,-550.781 2404,-560 2413.83,-556.049 2409.22,-550.781"/>
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<!-- GO:0051248 -->
<g id="node112" class="node"><title>GO:0051248</title>
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<polygon style="fill:none;stroke:black;" points="1707,-345 1707,-387 1797,-387 1797,-345 1707,-345"/>
<text text-anchor="middle" x="1752" y="-376.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="1752" y="-364.667" style="font-family:Arial;font-size:10px;">of protein metabolic</text>
<text text-anchor="middle" x="1752" y="-352.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0010605&#45;&gt;GO:0051248 -->
<g id="edge417" class="edge"><title>GO:0010605&#45;&gt;GO:0051248</title>
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<!-- GO:0010559&#45;&gt;GO:0010561 -->
<g id="edge351" class="edge"><title>GO:0010559&#45;&gt;GO:0010561</title>
<path style="fill:none;stroke:gray;" d="M2596,-331C2585,-318 2574,-304 2565,-292"/>
<polygon style="fill:gray;stroke:gray;" points="2593.2,-333.1 2602,-339 2598.8,-328.9 2593.2,-333.1"/>
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<!-- GO:0042984 -->
<g id="node113" class="node"><title>GO:0042984</title>
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<polygon style="fill:none;stroke:black;" points="2620,-238 2620,-292 2710,-292 2710,-238 2620,-238"/>
<text text-anchor="middle" x="2665" y="-281.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="2665" y="-269.667" style="font-family:Arial;font-size:10px;">amyloid precursor</text>
<text text-anchor="middle" x="2665" y="-257.667" style="font-family:Arial;font-size:10px;">protein biosynthetic</text>
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<!-- GO:0010559&#45;&gt;GO:0042984 -->
<g id="edge427" class="edge"><title>GO:0010559&#45;&gt;GO:0042984</title>
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<polygon style="fill:gray;stroke:gray;" points="2634.86,-328.44 2634,-339 2641.26,-331.283 2634.86,-328.44"/>
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<!-- GO:0009101&#45;&gt;GO:0010561 -->
<g id="edge389" class="edge"><title>GO:0009101&#45;&gt;GO:0010561</title>
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<!-- GO:0009101&#45;&gt;GO:0010559 -->
<g id="edge357" class="edge"><title>GO:0009101&#45;&gt;GO:0010559</title>
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<!-- GO:0042983 -->
<g id="node114" class="node"><title>GO:0042983</title>
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<text text-anchor="middle" x="2731" y="-376.667" style="font-family:Arial;font-size:10px;">amyloid precursor</text>
<text text-anchor="middle" x="2731" y="-364.667" style="font-family:Arial;font-size:10px;">protein biosynthetic</text>
<text text-anchor="middle" x="2731" y="-352.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009101&#45;&gt;GO:0042983 -->
<g id="edge431" class="edge"><title>GO:0009101&#45;&gt;GO:0042983</title>
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<!-- GO:0009100&#45;&gt;GO:0009101 -->
<g id="edge359" class="edge"><title>GO:0009100&#45;&gt;GO:0009101</title>
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<!-- GO:0042982 -->
<g id="node115" class="node"><title>GO:0042982</title>
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<text text-anchor="middle" x="2730" y="-477.667" style="font-family:Arial;font-size:10px;">protein metabolic</text>
<text text-anchor="middle" x="2730" y="-465.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009100&#45;&gt;GO:0042982 -->
<g id="edge435" class="edge"><title>GO:0009100&#45;&gt;GO:0042982</title>
<path style="fill:none;stroke:gray;" d="M2658,-559C2674,-541 2695,-517 2711,-500"/>
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<!-- GO:0031327&#45;&gt;GO:0010561 -->
<g id="edge365" class="edge"><title>GO:0031327&#45;&gt;GO:0010561</title>
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<!-- GO:0031324&#45;&gt;GO:0031327 -->
<g id="edge369" class="edge"><title>GO:0031324&#45;&gt;GO:0031327</title>
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<!-- GO:0032269 -->
<g id="node107" class="node"><title>GO:0032269</title>
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<polygon style="fill:none;stroke:black;" points="1910,-238 1910,-292 1996,-292 1996,-238 1910,-238"/>
<text text-anchor="middle" x="1953" y="-281.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
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<text text-anchor="middle" x="1953" y="-257.667" style="font-family:Arial;font-size:10px;">protein metabolic</text>
<text text-anchor="middle" x="1953" y="-245.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0031324&#45;&gt;GO:0032269 -->
<g id="edge393" class="edge"><title>GO:0031324&#45;&gt;GO:0032269</title>
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<!-- GO:0048523&#45;&gt;GO:0031324 -->
<g id="edge375" class="edge"><title>GO:0048523&#45;&gt;GO:0031324</title>
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<!-- GO:0032269&#45;&gt;GO:0042985 -->
<g id="edge391" class="edge"><title>GO:0032269&#45;&gt;GO:0042985</title>
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<!-- GO:0032268&#45;&gt;GO:0032269 -->
<g id="edge395" class="edge"><title>GO:0032268&#45;&gt;GO:0032269</title>
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<!-- GO:0051246&#45;&gt;GO:0032268 -->
<g id="edge399" class="edge"><title>GO:0051246&#45;&gt;GO:0032268</title>
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