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</g>
<!-- GO:0002376 -->
<g id="node368" class="node"><title>GO:0002376</title>
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<text text-anchor="middle" x="4645" y="-1151.67" style="font-family:Arial;font-size:10px;">immune system</text>
<text text-anchor="middle" x="4645" y="-1139.67" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0008150&#45;&gt;GO:0002376 -->
<g id="edge1275" class="edge"><title>GO:0008150&#45;&gt;GO:0002376</title>
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</g>
<!-- GO:0048844 -->
<g id="node5" class="node"><title>GO:0048844</title>
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<polygon style="fill:none;stroke:black;" points="1963,-471 1963,-487 2063,-487 2063,-471 1963,-471"/>
<text text-anchor="middle" x="2013" y="-476.667" style="font-family:Arial;font-size:10px;">artery morphogenesis</text>
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<text text-anchor="middle" x="2013" y="-460.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2013" y="-444.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0060017 -->
<g id="node6" class="node"><title>GO:0060017</title>
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<polygon style="fill:none;stroke:black;" points="4023,-672 4023,-702 4109,-702 4109,-672 4023,-672"/>
<text text-anchor="middle" x="4066" y="-691.667" style="font-family:Arial;font-size:10px;">parathyroid</text>
<text text-anchor="middle" x="4066" y="-679.667" style="font-family:Arial;font-size:10px;">gland development</text>
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<text text-anchor="middle" x="4066" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="4066" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0008284 -->
<g id="node7" class="node"><title>GO:0008284</title>
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<text text-anchor="middle" x="5962" y="-799.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="5962" y="-787.667" style="font-family:Arial;font-size:10px;">of cell proliferation</text>
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<text text-anchor="middle" x="5962" y="-769.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="5962" y="-753.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0043066 -->
<g id="node8" class="node"><title>GO:0043066</title>
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<polygon style="fill:none;stroke:black;" points="5605,-574 5605,-604 5691,-604 5691,-574 5605,-574"/>
<text text-anchor="middle" x="5648" y="-593.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="5648" y="-581.667" style="font-family:Arial;font-size:10px;">of apoptosis</text>
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<polygon style="fill:none;stroke:black;" points="5605,-558 5605,-574 5691,-574 5691,-558 5605,-558"/>
<text text-anchor="middle" x="5648" y="-563.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="5648" y="-547.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0006916 -->
<g id="node365" class="node"><title>GO:0006916</title>
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<polygon style="fill:none;stroke:black;" points="5708,-455 5708,-471 5774,-471 5774,-455 5708,-455"/>
<text text-anchor="middle" x="5741" y="-460.667" style="font-family:Arial;font-size:10px;">anti&#45;apoptosis</text>
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<!-- GO:0043066&#45;&gt;GO:0006916 -->
<g id="edge1263" class="edge"><title>GO:0043066&#45;&gt;GO:0006916</title>
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</g>
<!-- GO:0004703 -->
<g id="node9" class="node"><title>GO:0004703</title>
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<polygon style="fill:none;stroke:black;" points="56,-546 56,-600 138,-600 138,-546 56,-546"/>
<text text-anchor="middle" x="97" y="-589.667" style="font-family:Arial;font-size:10px;">G&#45;protein coupled</text>
<text text-anchor="middle" x="97" y="-577.667" style="font-family:Arial;font-size:10px;">receptor kinase</text>
<text text-anchor="middle" x="97" y="-565.667" style="font-family:Arial;font-size:10px;">activity</text>
<text text-anchor="middle" x="97" y="-553.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0001701 -->
<g id="node10" class="node"><title>GO:0001701</title>
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<polygon style="fill:none;stroke:black;" points="4566,-672 4566,-702 4652,-702 4652,-672 4566,-672"/>
<text text-anchor="middle" x="4609" y="-691.667" style="font-family:Arial;font-size:10px;">in utero embryonic</text>
<text text-anchor="middle" x="4609" y="-679.667" style="font-family:Arial;font-size:10px;">development</text>
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<text text-anchor="middle" x="4609" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="4609" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0001824 -->
<g id="node320" class="node"><title>GO:0001824</title>
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<text text-anchor="middle" x="4609" y="-570.667" style="font-family:Arial;font-size:10px;">blastocyst development</text>
</g>
<!-- GO:0001701&#45;&gt;GO:0001824 -->
<g id="edge1037" class="edge"><title>GO:0001701&#45;&gt;GO:0001824</title>
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</g>
<!-- GO:0019915 -->
<g id="node11" class="node"><title>GO:0019915</title>
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<polygon style="fill:none;stroke:black;" points="9483,-780 9483,-810 9549,-810 9549,-780 9483,-780"/>
<text text-anchor="middle" x="9516" y="-799.667" style="font-family:Arial;font-size:10px;">sequestering</text>
<text text-anchor="middle" x="9516" y="-787.667" style="font-family:Arial;font-size:10px;">of lipid</text>
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<polygon style="fill:none;stroke:black;" points="9483,-764 9483,-780 9549,-780 9549,-764 9483,-764"/>
<text text-anchor="middle" x="9516" y="-769.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="9483,-748 9483,-764 9549,-764 9549,-748 9483,-748"/>
<text text-anchor="middle" x="9516" y="-753.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0010468 -->
<g id="node12" class="node"><title>GO:0010468</title>
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<polygon style="fill:none;stroke:black;" points="7991,-672 7991,-702 8069,-702 8069,-672 7991,-672"/>
<text text-anchor="middle" x="8030" y="-691.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="8030" y="-679.667" style="font-family:Arial;font-size:10px;">gene expression</text>
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<polygon style="fill:none;stroke:black;" points="7991,-656 7991,-672 8069,-672 8069,-656 7991,-656"/>
<text text-anchor="middle" x="8030" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="7991,-640 7991,-656 8069,-656 8069,-640 7991,-640"/>
<text text-anchor="middle" x="8030" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0045449 -->
<g id="node89" class="node"><title>GO:0045449</title>
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<polygon style="fill:none;stroke:black;" points="8799,-574 8799,-604 8865,-604 8865,-574 8799,-574"/>
<text text-anchor="middle" x="8832" y="-593.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="8832" y="-581.667" style="font-family:Arial;font-size:10px;">transcription</text>
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<polygon style="fill:none;stroke:black;" points="8799,-558 8799,-574 8865,-574 8865,-558 8799,-558"/>
<text text-anchor="middle" x="8832" y="-563.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="8832" y="-547.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0010468&#45;&gt;GO:0045449 -->
<g id="edge759" class="edge"><title>GO:0010468&#45;&gt;GO:0045449</title>
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</g>
<!-- GO:0010628 -->
<g id="node296" class="node"><title>GO:0010628</title>
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<text text-anchor="middle" x="8105" y="-577.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8105" y="-565.667" style="font-family:Arial;font-size:10px;">of gene expression</text>
</g>
<!-- GO:0010468&#45;&gt;GO:0010628 -->
<g id="edge893" class="edge"><title>GO:0010468&#45;&gt;GO:0010628</title>
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<polygon style="fill:gray;stroke:gray;" points="8042.6,-630.454 8038,-640 8047.55,-635.404 8042.6,-630.454"/>
</g>
<!-- GO:0045884 -->
<g id="node364" class="node"><title>GO:0045884</title>
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<text text-anchor="middle" x="6055" y="-353.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="6055" y="-341.667" style="font-family:Arial;font-size:10px;">survival gene</text>
<text text-anchor="middle" x="6055" y="-329.667" style="font-family:Arial;font-size:10px;">product expression</text>
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<!-- GO:0010468&#45;&gt;GO:0045884 -->
<g id="edge1265" class="edge"><title>GO:0010468&#45;&gt;GO:0045884</title>
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</g>
<!-- GO:0006917 -->
<g id="node13" class="node"><title>GO:0006917</title>
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<text text-anchor="middle" x="5199" y="-483.667" style="font-family:Arial;font-size:10px;">induction of</text>
<text text-anchor="middle" x="5199" y="-471.667" style="font-family:Arial;font-size:10px;">apoptosis</text>
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<text text-anchor="middle" x="5199" y="-453.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="5166,-432 5166,-448 5232,-448 5232,-432 5166,-432"/>
<text text-anchor="middle" x="5199" y="-437.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0007165 -->
<g id="node14" class="node"><title>GO:0007165</title>
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<polygon style="fill:none;stroke:black;" points="6185,-904 6185,-920 6273,-920 6273,-904 6185,-904"/>
<text text-anchor="middle" x="6229" y="-909.667" style="font-family:Arial;font-size:10px;">signal transduction</text>
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<text text-anchor="middle" x="6229" y="-893.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="6185,-872 6185,-888 6273,-888 6273,-872 6185,-872"/>
<text text-anchor="middle" x="6229" y="-877.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="6185,-856 6185,-872 6273,-872 6273,-856 6185,-856"/>
<text text-anchor="middle" x="6229" y="-861.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0007242 -->
<g id="node202" class="node"><title>GO:0007242</title>
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<text text-anchor="middle" x="6118" y="-783.667" style="font-family:Arial;font-size:10px;">intracellular</text>
<text text-anchor="middle" x="6118" y="-771.667" style="font-family:Arial;font-size:10px;">signaling cascade</text>
</g>
<!-- GO:0007165&#45;&gt;GO:0007242 -->
<g id="edge449" class="edge"><title>GO:0007165&#45;&gt;GO:0007242</title>
<path style="fill:none;stroke:gray;" d="M6210,-850C6200,-843 6187,-834 6177,-826 6163,-815 6148,-803 6137,-794"/>
<polygon style="fill:gray;stroke:gray;" points="6207.9,-852.8 6218,-856 6212.1,-847.2 6207.9,-852.8"/>
</g>
<!-- GO:0009967 -->
<g id="node224" class="node"><title>GO:0009967</title>
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<text text-anchor="middle" x="6320" y="-675.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6320" y="-663.667" style="font-family:Arial;font-size:10px;">of signal transduction</text>
</g>
<!-- GO:0007165&#45;&gt;GO:0009967 -->
<g id="edge561" class="edge"><title>GO:0007165&#45;&gt;GO:0009967</title>
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<!-- GO:0009966 -->
<g id="node225" class="node"><title>GO:0009966</title>
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<text text-anchor="middle" x="6238" y="-783.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="6238" y="-771.667" style="font-family:Arial;font-size:10px;">signal transduction</text>
</g>
<!-- GO:0007165&#45;&gt;GO:0009966 -->
<g id="edge551" class="edge"><title>GO:0007165&#45;&gt;GO:0009966</title>
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<!-- GO:0007166 -->
<g id="node347" class="node"><title>GO:0007166</title>
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<text text-anchor="middle" x="6398" y="-789.667" style="font-family:Arial;font-size:10px;">cell surface</text>
<text text-anchor="middle" x="6398" y="-777.667" style="font-family:Arial;font-size:10px;">receptor linked</text>
<text text-anchor="middle" x="6398" y="-765.667" style="font-family:Arial;font-size:10px;">signal transduction</text>
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<!-- GO:0007165&#45;&gt;GO:0007166 -->
<g id="edge1177" class="edge"><title>GO:0007165&#45;&gt;GO:0007166</title>
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<!-- GO:0032868 -->
<g id="node15" class="node"><title>GO:0032868</title>
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<text text-anchor="middle" x="10648" y="-799.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10648" y="-787.667" style="font-family:Arial;font-size:10px;">insulin stimulus</text>
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<text text-anchor="middle" x="10648" y="-769.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0007455 -->
<g id="node16" class="node"><title>GO:0007455</title>
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<text text-anchor="middle" x="2703" y="-583.667" style="font-family:Arial;font-size:10px;">eye&#45;antennal</text>
<text text-anchor="middle" x="2703" y="-571.667" style="font-family:Arial;font-size:10px;">disc morphogenesis</text>
<text text-anchor="middle" x="2703" y="-559.667" style="font-family:Arial;font-size:10px;">Fly</text>
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<!-- GO:0007405 -->
<g id="node17" class="node"><title>GO:0007405</title>
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<text text-anchor="middle" x="5814" y="-577.667" style="font-family:Arial;font-size:10px;">neuroblast proliferation</text>
<text text-anchor="middle" x="5814" y="-565.667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0048701 -->
<g id="node18" class="node"><title>GO:0048701</title>
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<text text-anchor="middle" x="2186" y="-483.667" style="font-family:Arial;font-size:10px;">embryonic cranial</text>
<text text-anchor="middle" x="2186" y="-471.667" style="font-family:Arial;font-size:10px;">skeleton morphogenesis</text>
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<text text-anchor="middle" x="2186" y="-453.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2186" y="-437.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0006468 -->
<g id="node19" class="node"><title>GO:0006468</title>
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<polygon style="fill:none;stroke:black;" points="7343,-472 7343,-502 7439,-502 7439,-472 7343,-472"/>
<text text-anchor="middle" x="7391" y="-491.667" style="font-family:Arial;font-size:10px;">protein amino</text>
<text text-anchor="middle" x="7391" y="-479.667" style="font-family:Arial;font-size:10px;">acid phosphorylation</text>
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<text text-anchor="middle" x="7391" y="-445.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<text text-anchor="middle" x="7391" y="-429.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
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<!-- GO:0000186 -->
<g id="node24" class="node"><title>GO:0000186</title>
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<text text-anchor="middle" x="6984" y="-363.667" style="font-family:Arial;font-size:10px;">activation of</text>
<text text-anchor="middle" x="6984" y="-351.667" style="font-family:Arial;font-size:10px;">MAPKK activity</text>
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<text text-anchor="middle" x="6984" y="-317.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0006468&#45;&gt;GO:0000186 -->
<g id="edge413" class="edge"><title>GO:0006468&#45;&gt;GO:0000186</title>
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<polygon style="fill:gray;stroke:gray;" points="7335.51,-425.471 7346,-424 7336.88,-418.607 7335.51,-425.471"/>
</g>
<!-- GO:0046777 -->
<g id="node38" class="node"><title>GO:0046777</title>
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<polygon style="fill:none;stroke:black;" points="7334,-322 7334,-364 7448,-364 7448,-322 7334,-322"/>
<text text-anchor="middle" x="7391" y="-353.667" style="font-family:Arial;font-size:10px;">protein amino</text>
<text text-anchor="middle" x="7391" y="-341.667" style="font-family:Arial;font-size:10px;">acid autophosphorylation</text>
<text text-anchor="middle" x="7391" y="-329.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<!-- GO:0006468&#45;&gt;GO:0046777 -->
<g id="edge537" class="edge"><title>GO:0006468&#45;&gt;GO:0046777</title>
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<polygon style="fill:gray;stroke:gray;" points="7387.5,-414 7391,-424 7394.5,-414 7387.5,-414"/>
</g>
<!-- GO:0009952 -->
<g id="node20" class="node"><title>GO:0009952</title>
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<polygon style="fill:none;stroke:black;" points="3982,-780 3982,-810 4060,-810 4060,-780 3982,-780"/>
<text text-anchor="middle" x="4021" y="-799.667" style="font-family:Arial;font-size:10px;">anterior/posterior</text>
<text text-anchor="middle" x="4021" y="-787.667" style="font-family:Arial;font-size:10px;">pattern formation</text>
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<polygon style="fill:none;stroke:black;" points="3982,-764 3982,-780 4060,-780 4060,-764 3982,-764"/>
<text text-anchor="middle" x="4021" y="-769.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="4021" y="-753.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005024 -->
<g id="node21" class="node"><title>GO:0005024</title>
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<polygon style="fill:none;stroke:black;" points="238,-332 238,-386 304,-386 304,-332 238,-332"/>
<text text-anchor="middle" x="271" y="-375.667" style="font-family:Arial;font-size:10px;">transforming</text>
<text text-anchor="middle" x="271" y="-363.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="271" y="-351.667" style="font-family:Arial;font-size:10px;">beta receptor</text>
<text text-anchor="middle" x="271" y="-339.667" style="font-family:Arial;font-size:10px;">activity</text>
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<text text-anchor="middle" x="271" y="-321.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="238,-300 238,-316 304,-316 304,-300 238,-300"/>
<text text-anchor="middle" x="271" y="-305.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005025 -->
<g id="node54" class="node"><title>GO:0005025</title>
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<polygon style="fill:none;stroke:black;" points="188,-208 188,-274 252,-274 252,-208 188,-208"/>
<text text-anchor="middle" x="220" y="-263.667" style="font-family:Arial;font-size:10px;">transforming</text>
<text text-anchor="middle" x="220" y="-251.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="220" y="-239.667" style="font-family:Arial;font-size:10px;">beta receptor</text>
<text text-anchor="middle" x="220" y="-227.667" style="font-family:Arial;font-size:10px;">activity, type</text>
<text text-anchor="middle" x="220" y="-215.667" style="font-family:Arial;font-size:10px;">I</text>
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<polygon style="fill:none;stroke:black;" points="188,-192 188,-208 252,-208 252,-192 188,-192"/>
<text text-anchor="middle" x="220" y="-197.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<polygon style="fill:none;stroke:black;" points="188,-176 188,-192 252,-192 252,-176 188,-176"/>
<text text-anchor="middle" x="220" y="-181.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0005024&#45;&gt;GO:0005025 -->
<g id="edge505" class="edge"><title>GO:0005024&#45;&gt;GO:0005025</title>
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<polygon style="fill:gray;stroke:gray;" points="256.2,-294.1 265,-300 261.8,-289.9 256.2,-294.1"/>
</g>
<!-- GO:0017002 -->
<g id="node216" class="node"><title>GO:0017002</title>
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<polygon style="fill:none;stroke:black;" points="286,-210 286,-240 358,-240 358,-210 286,-210"/>
<text text-anchor="middle" x="322" y="-229.667" style="font-family:Arial;font-size:10px;">activin receptor</text>
<text text-anchor="middle" x="322" y="-217.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0005024&#45;&gt;GO:0017002 -->
<g id="edge509" class="edge"><title>GO:0005024&#45;&gt;GO:0017002</title>
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<polygon style="fill:gray;stroke:gray;" points="278.635,-289.738 276,-300 284.459,-293.621 278.635,-289.738"/>
</g>
<!-- GO:0016324 -->
<g id="node22" class="node"><title>GO:0016324</title>
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<polygon style="fill:none;stroke:black;" points="1648,-650 1648,-692 1714,-692 1714,-650 1648,-650"/>
<text text-anchor="middle" x="1681" y="-681.667" style="font-family:Arial;font-size:10px;">apical plasma</text>
<text text-anchor="middle" x="1681" y="-669.667" style="font-family:Arial;font-size:10px;">membrane</text>
<text text-anchor="middle" x="1681" y="-657.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0031625 -->
<g id="node23" class="node"><title>GO:0031625</title>
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<text text-anchor="middle" x="878" y="-898.667" style="font-family:Arial;font-size:10px;">ubiquitin protein</text>
<text text-anchor="middle" x="878" y="-886.667" style="font-family:Arial;font-size:10px;">ligase binding</text>
<text text-anchor="middle" x="878" y="-874.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0007346 -->
<g id="node25" class="node"><title>GO:0007346</title>
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<text text-anchor="middle" x="6752" y="-795.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<text text-anchor="middle" x="6752" y="-771.667" style="font-family:Arial;font-size:10px;">cycle</text>
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</g>
<!-- GO:0040024 -->
<g id="node26" class="node"><title>GO:0040024</title>
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<text text-anchor="middle" x="4502" y="-681.667" style="font-family:Arial;font-size:10px;">dauer larval</text>
<text text-anchor="middle" x="4502" y="-669.667" style="font-family:Arial;font-size:10px;">development</text>
<text text-anchor="middle" x="4502" y="-657.667" style="font-family:Arial;font-size:10px;">Worm</text>
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<!-- GO:0030199 -->
<g id="node27" class="node"><title>GO:0030199</title>
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<text text-anchor="middle" x="5066" y="-691.667" style="font-family:Arial;font-size:10px;">collagen fibril</text>
<text text-anchor="middle" x="5066" y="-679.667" style="font-family:Arial;font-size:10px;">organization</text>
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<text text-anchor="middle" x="5066" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="5066" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0007568 -->
<g id="node28" class="node"><title>GO:0007568</title>
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<text text-anchor="middle" x="4720" y="-1078.67" style="font-family:Arial;font-size:10px;">aging</text>
<text text-anchor="middle" x="4720" y="-1066.67" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0016323 -->
<g id="node29" class="node"><title>GO:0016323</title>
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<polygon style="fill:none;stroke:black;" points="1490,-650 1490,-692 1576,-692 1576,-650 1490,-650"/>
<text text-anchor="middle" x="1533" y="-681.667" style="font-family:Arial;font-size:10px;">basolateral</text>
<text text-anchor="middle" x="1533" y="-669.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
<text text-anchor="middle" x="1533" y="-657.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0048870 -->
<g id="node30" class="node"><title>GO:0048870</title>
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<polygon style="fill:none;stroke:black;" points="9382,-896 9382,-912 9448,-912 9448,-896 9382,-896"/>
<text text-anchor="middle" x="9415" y="-901.667" style="font-family:Arial;font-size:10px;">cell motility</text>
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<polygon style="fill:none;stroke:black;" points="9382,-880 9382,-896 9448,-896 9448,-880 9382,-880"/>
<text text-anchor="middle" x="9415" y="-885.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="9382,-864 9382,-880 9448,-880 9448,-864 9382,-864"/>
<text text-anchor="middle" x="9415" y="-869.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0016477 -->
<g id="node217" class="node"><title>GO:0016477</title>
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<text text-anchor="middle" x="9416" y="-776.667" style="font-family:Arial;font-size:10px;">cell migration</text>
</g>
<!-- GO:0048870&#45;&gt;GO:0016477 -->
<g id="edge515" class="edge"><title>GO:0048870&#45;&gt;GO:0016477</title>
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<!-- GO:0048666 -->
<g id="node31" class="node"><title>GO:0048666</title>
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<text text-anchor="middle" x="5358" y="-467.667" style="font-family:Arial;font-size:10px;">neuron development</text>
<text text-anchor="middle" x="5358" y="-455.667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0031175 -->
<g id="node329" class="node"><title>GO:0031175</title>
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<text text-anchor="middle" x="5294" y="-340.667" style="font-family:Arial;font-size:10px;">neurite development</text>
</g>
<!-- GO:0048666&#45;&gt;GO:0031175 -->
<g id="edge1087" class="edge"><title>GO:0048666&#45;&gt;GO:0031175</title>
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</g>
<!-- GO:0048667 -->
<g id="node330" class="node"><title>GO:0048667</title>
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<text text-anchor="middle" x="5422" y="-353.667" style="font-family:Arial;font-size:10px;">cell morphogenesis</text>
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<!-- GO:0048666&#45;&gt;GO:0048667 -->
<g id="edge1097" class="edge"><title>GO:0048666&#45;&gt;GO:0048667</title>
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<!-- GO:0016361 -->
<g id="node32" class="node"><title>GO:0016361</title>
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<polygon style="fill:none;stroke:black;" points="235,-108 235,-150 307,-150 307,-108 235,-108"/>
<text text-anchor="middle" x="271" y="-139.667" style="font-family:Arial;font-size:10px;">activin receptor</text>
<text text-anchor="middle" x="271" y="-127.667" style="font-family:Arial;font-size:10px;">activity, type</text>
<text text-anchor="middle" x="271" y="-115.667" style="font-family:Arial;font-size:10px;">I</text>
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<text text-anchor="middle" x="271" y="-65.6667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
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<!-- GO:0001501 -->
<g id="node33" class="node"><title>GO:0001501</title>
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<text text-anchor="middle" x="2316" y="-799.667" style="font-family:Arial;font-size:10px;">skeletal system</text>
<text text-anchor="middle" x="2316" y="-787.667" style="font-family:Arial;font-size:10px;">development</text>
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<text text-anchor="middle" x="2316" y="-769.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0048705 -->
<g id="node41" class="node"><title>GO:0048705</title>
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<polygon style="fill:none;stroke:black;" points="2148,-672 2148,-702 2224,-702 2224,-672 2148,-672"/>
<text text-anchor="middle" x="2186" y="-691.667" style="font-family:Arial;font-size:10px;">skeletal system</text>
<text text-anchor="middle" x="2186" y="-679.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
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<polygon style="fill:none;stroke:black;" points="2148,-656 2148,-672 2224,-672 2224,-656 2148,-656"/>
<text text-anchor="middle" x="2186" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2186" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0001501&#45;&gt;GO:0048705 -->
<g id="edge299" class="edge"><title>GO:0001501&#45;&gt;GO:0048705</title>
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<polygon style="fill:blue;stroke:blue;" points="2290.56,-746.203 2301,-748 2293.96,-740.084 2290.56,-746.203"/>
</g>
<!-- GO:0048706 -->
<g id="node159" class="node"><title>GO:0048706</title>
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<polygon style="fill:none;stroke:black;" points="2258,-656 2258,-686 2354,-686 2354,-656 2258,-656"/>
<text text-anchor="middle" x="2306" y="-675.667" style="font-family:Arial;font-size:10px;">embryonic skeletal</text>
<text text-anchor="middle" x="2306" y="-663.667" style="font-family:Arial;font-size:10px;">system development</text>
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<!-- GO:0001501&#45;&gt;GO:0048706 -->
<g id="edge305" class="edge"><title>GO:0001501&#45;&gt;GO:0048706</title>
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<polygon style="fill:gray;stroke:gray;" points="2310.52,-738.398 2315,-748 2317.49,-737.701 2310.52,-738.398"/>
</g>
<!-- GO:0046332 -->
<g id="node34" class="node"><title>GO:0046332</title>
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<polygon style="fill:none;stroke:black;" points="628,-993 628,-1009 696,-1009 696,-993 628,-993"/>
<text text-anchor="middle" x="662" y="-998.667" style="font-family:Arial;font-size:10px;">SMAD binding</text>
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<polygon style="fill:none;stroke:black;" points="628,-977 628,-993 696,-993 696,-977 628,-977"/>
<text text-anchor="middle" x="662" y="-982.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="662" y="-966.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0008354 -->
<g id="node35" class="node"><title>GO:0008354</title>
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<polygon style="fill:none;stroke:black;" points="9457,-679 9457,-695 9545,-695 9545,-679 9457,-679"/>
<text text-anchor="middle" x="9501" y="-684.667" style="font-family:Arial;font-size:10px;">germ cell migration</text>
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<polygon style="fill:none;stroke:black;" points="9457,-663 9457,-679 9545,-679 9545,-663 9457,-663"/>
<text text-anchor="middle" x="9501" y="-668.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="9457,-647 9457,-663 9545,-663 9545,-647 9457,-647"/>
<text text-anchor="middle" x="9501" y="-652.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0009790 -->
<g id="node36" class="node"><title>GO:0009790</title>
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<polygon style="fill:none;stroke:black;" points="3960,-993 3960,-1009 4068,-1009 4068,-993 3960,-993"/>
<text text-anchor="middle" x="4014" y="-998.667" style="font-family:Arial;font-size:10px;">embryonic development</text>
<polygon style="fill:gold;stroke:gold;" points="3960,-977 3960,-993 4068,-993 4068,-977 3960,-977"/>
<polygon style="fill:none;stroke:black;" points="3960,-977 3960,-993 4068,-993 4068,-977 3960,-977"/>
<text text-anchor="middle" x="4014" y="-982.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<polygon style="fill:none;stroke:black;" points="3960,-961 3960,-977 4068,-977 4068,-961 3960,-961"/>
<text text-anchor="middle" x="4014" y="-966.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0009792 -->
<g id="node128" class="node"><title>GO:0009792</title>
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<polygon style="fill:none;stroke:black;" points="4216,-867 4216,-909 4324,-909 4324,-867 4216,-867"/>
<text text-anchor="middle" x="4270" y="-898.667" style="font-family:Arial;font-size:10px;">embryonic development</text>
<text text-anchor="middle" x="4270" y="-886.667" style="font-family:Arial;font-size:10px;">ending in birth</text>
<text text-anchor="middle" x="4270" y="-874.667" style="font-family:Arial;font-size:10px;">or egg hatching</text>
</g>
<!-- GO:0009790&#45;&gt;GO:0009792 -->
<g id="edge157" class="edge"><title>GO:0009790&#45;&gt;GO:0009792</title>
<path style="fill:none;stroke:gray;" d="M4051,-958C4062,-955 4074,-952 4085,-950 4136,-939 4151,-949 4199,-932 4214,-926 4229,-918 4242,-909"/>
<polygon style="fill:gray;stroke:gray;" points="4049.57,-954.774 4041,-961 4051.58,-961.479 4049.57,-954.774"/>
</g>
<!-- GO:0048598 -->
<g id="node158" class="node"><title>GO:0048598</title>
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<polygon style="fill:none;stroke:black;" points="2550,-880 2550,-896 2670,-896 2670,-880 2550,-880"/>
<text text-anchor="middle" x="2610" y="-885.667" style="font-family:Arial;font-size:10px;">embryonic morphogenesis</text>
</g>
<!-- GO:0009790&#45;&gt;GO:0048598 -->
<g id="edge293" class="edge"><title>GO:0009790&#45;&gt;GO:0048598</title>
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</g>
<!-- GO:0031100 -->
<g id="node37" class="node"><title>GO:0031100</title>
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<polygon style="fill:none;stroke:black;" points="1858,-656 1858,-686 1944,-686 1944,-656 1858,-656"/>
<text text-anchor="middle" x="1901" y="-675.667" style="font-family:Arial;font-size:10px;">organ regeneration</text>
<text text-anchor="middle" x="1901" y="-663.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0043065 -->
<g id="node39" class="node"><title>GO:0043065</title>
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<text text-anchor="middle" x="5274" y="-583.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="5274" y="-571.667" style="font-family:Arial;font-size:10px;">of apoptosis</text>
<text text-anchor="middle" x="5274" y="-559.667" style="font-family:Arial;font-size:10px;">Mouse: ISS_only</text>
</g>
<!-- GO:0043065&#45;&gt;GO:0006917 -->
<g id="edge205" class="edge"><title>GO:0043065&#45;&gt;GO:0006917</title>
<path style="fill:none;stroke:gray;" d="M5251,-544C5238,-527 5222,-508 5211,-494"/>
<polygon style="fill:gray;stroke:gray;" points="5248.2,-546.1 5257,-552 5253.8,-541.9 5248.2,-546.1"/>
</g>
<!-- GO:0051897 -->
<g id="node40" class="node"><title>GO:0051897</title>
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<polygon style="fill:none;stroke:black;" points="6146,-332 6146,-386 6230,-386 6230,-332 6146,-332"/>
<text text-anchor="middle" x="6188" y="-375.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6188" y="-363.667" style="font-family:Arial;font-size:10px;">of protein kinase</text>
<text text-anchor="middle" x="6188" y="-351.667" style="font-family:Arial;font-size:10px;">B signaling</text>
<text text-anchor="middle" x="6188" y="-339.667" style="font-family:Arial;font-size:10px;">cascade</text>
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<text text-anchor="middle" x="6188" y="-321.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="6146,-300 6146,-316 6230,-316 6230,-300 6146,-300"/>
<text text-anchor="middle" x="6188" y="-305.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0048704 -->
<g id="node157" class="node"><title>GO:0048704</title>
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<polygon style="fill:none;stroke:black;" points="2132,-558 2132,-588 2240,-588 2240,-558 2132,-558"/>
<text text-anchor="middle" x="2186" y="-577.667" style="font-family:Arial;font-size:10px;">embryonic skeletal</text>
<text text-anchor="middle" x="2186" y="-565.667" style="font-family:Arial;font-size:10px;">system morphogenesis</text>
</g>
<!-- GO:0048705&#45;&gt;GO:0048704 -->
<g id="edge295" class="edge"><title>GO:0048705&#45;&gt;GO:0048704</title>
<path style="fill:none;stroke:gray;" d="M2186,-630C2186,-617 2186,-600 2186,-588"/>
<polygon style="fill:gray;stroke:gray;" points="2182.5,-630 2186,-640 2189.5,-630 2182.5,-630"/>
</g>
<!-- GO:0034695 -->
<g id="node42" class="node"><title>GO:0034695</title>
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<polygon style="fill:none;stroke:black;" points="10235,-644 10235,-698 10299,-698 10299,-644 10235,-644"/>
<text text-anchor="middle" x="10267" y="-687.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10267" y="-675.667" style="font-family:Arial;font-size:10px;">prostaglandin</text>
<text text-anchor="middle" x="10267" y="-663.667" style="font-family:Arial;font-size:10px;">E stimulus</text>
<text text-anchor="middle" x="10267" y="-651.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0046676 -->
<g id="node43" class="node"><title>GO:0046676</title>
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<polygon style="fill:none;stroke:black;" points="9853,-344 9853,-374 9941,-374 9941,-344 9853,-344"/>
<text text-anchor="middle" x="9897" y="-363.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="9897" y="-351.667" style="font-family:Arial;font-size:10px;">of insulin secretion</text>
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<polygon style="fill:none;stroke:black;" points="9853,-328 9853,-344 9941,-344 9941,-328 9853,-328"/>
<text text-anchor="middle" x="9897" y="-333.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="9853,-312 9853,-328 9941,-328 9941,-312 9853,-312"/>
<text text-anchor="middle" x="9897" y="-317.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005886 -->
<g id="node44" class="node"><title>GO:0005886</title>
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<polygon style="fill:none;stroke:black;" points="1489,-896 1489,-912 1575,-912 1575,-896 1489,-896"/>
<text text-anchor="middle" x="1532" y="-901.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
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<polygon style="fill:none;stroke:black;" points="1489,-880 1489,-896 1575,-896 1575,-880 1489,-880"/>
<text text-anchor="middle" x="1532" y="-885.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="1489,-864 1489,-880 1575,-880 1575,-864 1489,-864"/>
<text text-anchor="middle" x="1532" y="-869.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0044459 -->
<g id="node182" class="node"><title>GO:0044459</title>
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<polygon style="fill:none;stroke:black;" points="1489,-764 1489,-794 1575,-794 1575,-764 1489,-764"/>
<text text-anchor="middle" x="1532" y="-783.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
<text text-anchor="middle" x="1532" y="-771.667" style="font-family:Arial;font-size:10px;">part</text>
</g>
<!-- GO:0005886&#45;&gt;GO:0044459 -->
<g id="edge397" class="edge"><title>GO:0005886&#45;&gt;GO:0044459</title>
<path style="fill:none;stroke:blue;" d="M1532,-854C1532,-836 1532,-810 1532,-794"/>
<polygon style="fill:blue;stroke:blue;" points="1528.5,-854 1532,-864 1535.5,-854 1528.5,-854"/>
</g>
<!-- GO:0009636 -->
<g id="node45" class="node"><title>GO:0009636</title>
<polygon style="fill:gold;stroke:gold;" points="10162,-964 10162,-1006 10220,-1006 10220,-964 10162,-964"/>
<polygon style="fill:none;stroke:black;" points="10162,-964 10162,-1006 10220,-1006 10220,-964 10162,-964"/>
<text text-anchor="middle" x="10191" y="-995.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10191" y="-983.667" style="font-family:Arial;font-size:10px;">toxin</text>
<text text-anchor="middle" x="10191" y="-971.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0051491 -->
<g id="node46" class="node"><title>GO:0051491</title>
<polygon style="fill:white;stroke:white;" points="2948,-100 2948,-142 3032,-142 3032,-100 2948,-100"/>
<polygon style="fill:none;stroke:black;" points="2948,-100 2948,-142 3032,-142 3032,-100 2948,-100"/>
<text text-anchor="middle" x="2990" y="-131.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="2990" y="-119.667" style="font-family:Arial;font-size:10px;">of filopodium</text>
<text text-anchor="middle" x="2990" y="-107.667" style="font-family:Arial;font-size:10px;">formation</text>
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<polygon style="fill:none;stroke:black;" points="2948,-84 2948,-100 3032,-100 3032,-84 2948,-84"/>
<text text-anchor="middle" x="2990" y="-89.6667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="2948,-68 2948,-84 3032,-84 3032,-68 2948,-68"/>
<text text-anchor="middle" x="2990" y="-73.6667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0045944 -->
<g id="node47" class="node"><title>GO:0045944</title>
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<polygon style="fill:none;stroke:black;" points="8852,-192 8852,-258 8954,-258 8954,-192 8852,-192"/>
<text text-anchor="middle" x="8903" y="-247.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8903" y="-235.667" style="font-family:Arial;font-size:10px;">of transcription</text>
<text text-anchor="middle" x="8903" y="-223.667" style="font-family:Arial;font-size:10px;">from RNA polymerase</text>
<text text-anchor="middle" x="8903" y="-211.667" style="font-family:Arial;font-size:10px;">II promoter</text>
<text text-anchor="middle" x="8903" y="-199.667" style="font-family:Arial;font-size:10px;">Worm</text>
</g>
<!-- GO:0014070 -->
<g id="node48" class="node"><title>GO:0014070</title>
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<polygon style="fill:none;stroke:black;" points="10264,-861 10264,-915 10330,-915 10330,-861 10264,-861"/>
<text text-anchor="middle" x="10297" y="-904.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10297" y="-892.667" style="font-family:Arial;font-size:10px;">organic cyclic</text>
<text text-anchor="middle" x="10297" y="-880.667" style="font-family:Arial;font-size:10px;">substance</text>
<text text-anchor="middle" x="10297" y="-868.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<!-- GO:0032403 -->
<g id="node49" class="node"><title>GO:0032403</title>
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<text text-anchor="middle" x="768" y="-995.667" style="font-family:Arial;font-size:10px;">protein complex</text>
<text text-anchor="middle" x="768" y="-983.667" style="font-family:Arial;font-size:10px;">binding</text>
<text text-anchor="middle" x="768" y="-971.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0048185 -->
<g id="node68" class="node"><title>GO:0048185</title>
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<text text-anchor="middle" x="767" y="-917.667" style="font-family:Arial;font-size:10px;">activin binding</text>
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<text text-anchor="middle" x="767" y="-885.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<text text-anchor="middle" x="767" y="-869.667" style="font-family:Arial;font-size:10px;">Mouse: ISS_only</text>
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<text text-anchor="middle" x="767" y="-853.667" style="font-family:Arial;font-size:10px;">Fly</text>
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<!-- GO:0032403&#45;&gt;GO:0048185 -->
<g id="edge1169" class="edge"><title>GO:0032403&#45;&gt;GO:0048185</title>
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<polygon style="fill:gray;stroke:gray;" points="763.522,-954.398 768,-964 770.488,-953.701 763.522,-954.398"/>
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<!-- GO:0048663 -->
<g id="node50" class="node"><title>GO:0048663</title>
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<polygon style="fill:none;stroke:black;" points="5450,-464 5450,-494 5516,-494 5516,-464 5450,-464"/>
<text text-anchor="middle" x="5483" y="-483.667" style="font-family:Arial;font-size:10px;">neuron fate</text>
<text text-anchor="middle" x="5483" y="-471.667" style="font-family:Arial;font-size:10px;">commitment</text>
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<text text-anchor="middle" x="5483" y="-437.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0007566 -->
<g id="node51" class="node"><title>GO:0007566</title>
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<text text-anchor="middle" x="6726" y="-892.667" style="font-family:Arial;font-size:10px;">embryo implantation</text>
<text text-anchor="middle" x="6726" y="-880.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0051272 -->
<g id="node52" class="node"><title>GO:0051272</title>
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<polygon style="fill:none;stroke:black;" points="7468,-780 7468,-810 7552,-810 7552,-780 7468,-780"/>
<text text-anchor="middle" x="7510" y="-799.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="7510" y="-787.667" style="font-family:Arial;font-size:10px;">of cell motion</text>
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<text text-anchor="middle" x="7510" y="-769.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="7468,-748 7468,-764 7552,-764 7552,-748 7468,-748"/>
<text text-anchor="middle" x="7510" y="-753.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0070022 -->
<g id="node53" class="node"><title>GO:0070022</title>
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<polygon style="fill:none;stroke:black;" points="1580,-452 1580,-506 1644,-506 1644,-452 1580,-452"/>
<text text-anchor="middle" x="1612" y="-495.667" style="font-family:Arial;font-size:10px;">transforming</text>
<text text-anchor="middle" x="1612" y="-483.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="1612" y="-471.667" style="font-family:Arial;font-size:10px;">beta receptor</text>
<text text-anchor="middle" x="1612" y="-459.667" style="font-family:Arial;font-size:10px;">complex</text>
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<text text-anchor="middle" x="1612" y="-441.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="1580,-420 1580,-436 1644,-436 1644,-420 1580,-420"/>
<text text-anchor="middle" x="1612" y="-425.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0005025&#45;&gt;GO:0016361 -->
<g id="edge503" class="edge"><title>GO:0005025&#45;&gt;GO:0016361</title>
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</g>
<!-- GO:0005524 -->
<g id="node55" class="node"><title>GO:0005524</title>
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<polygon style="fill:none;stroke:black;" points="1151,-679 1151,-695 1209,-695 1209,-679 1151,-679"/>
<text text-anchor="middle" x="1180" y="-684.667" style="font-family:Arial;font-size:10px;">ATP binding</text>
<polygon style="fill:tomato;stroke:tomato;" points="1151,-663 1151,-679 1209,-679 1209,-663 1151,-663"/>
<polygon style="fill:none;stroke:black;" points="1151,-663 1151,-679 1209,-679 1209,-663 1151,-663"/>
<text text-anchor="middle" x="1180" y="-668.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="1180" y="-652.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0001834 -->
<g id="node56" class="node"><title>GO:0001834</title>
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<polygon style="fill:none;stroke:black;" points="5653,-322 5653,-364 5733,-364 5733,-322 5653,-322"/>
<text text-anchor="middle" x="5693" y="-353.667" style="font-family:Arial;font-size:10px;">trophectodermal</text>
<text text-anchor="middle" x="5693" y="-341.667" style="font-family:Arial;font-size:10px;">cell proliferation</text>
<text text-anchor="middle" x="5693" y="-329.667" style="font-family:Arial;font-size:10px;">Mouse: ISS_only</text>
</g>
<!-- GO:0060021 -->
<g id="node57" class="node"><title>GO:0060021</title>
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<polygon style="fill:none;stroke:black;" points="3494,-993 3494,-1009 3584,-1009 3584,-993 3494,-993"/>
<text text-anchor="middle" x="3539" y="-998.667" style="font-family:Arial;font-size:10px;">palate development</text>
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<polygon style="fill:none;stroke:black;" points="3494,-977 3494,-993 3584,-993 3584,-977 3494,-977"/>
<text text-anchor="middle" x="3539" y="-982.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="3494,-961 3494,-977 3584,-977 3584,-961 3494,-961"/>
<text text-anchor="middle" x="3539" y="-966.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0045602 -->
<g id="node58" class="node"><title>GO:0045602</title>
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<polygon style="fill:none;stroke:black;" points="4913,-644 4913,-698 4999,-698 4999,-644 4913,-644"/>
<text text-anchor="middle" x="4956" y="-687.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="4956" y="-675.667" style="font-family:Arial;font-size:10px;">of endothelial</text>
<text text-anchor="middle" x="4956" y="-663.667" style="font-family:Arial;font-size:10px;">cell differentiation</text>
<text text-anchor="middle" x="4956" y="-651.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0005515 -->
<g id="node59" class="node"><title>GO:0005515</title>
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<text text-anchor="middle" x="768" y="-1095.67" style="font-family:Arial;font-size:10px;">protein binding</text>
<polygon style="fill:gold;stroke:gold;" points="733,-1074 733,-1090 803,-1090 803,-1074 733,-1074"/>
<polygon style="fill:none;stroke:black;" points="733,-1074 733,-1090 803,-1090 803,-1074 733,-1074"/>
<text text-anchor="middle" x="768" y="-1079.67" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="733,-1058 733,-1074 803,-1074 803,-1058 733,-1058"/>
<text text-anchor="middle" x="768" y="-1063.67" style="font-family:Arial;font-size:10px;">Worm</text>
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<polygon style="fill:none;stroke:black;" points="733,-1042 733,-1058 803,-1058 803,-1042 733,-1042"/>
<text text-anchor="middle" x="768" y="-1047.67" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0046332 -->
<g id="edge511" class="edge"><title>GO:0005515&#45;&gt;GO:0046332</title>
<path style="fill:none;stroke:gray;" d="M741,-1038C721,-1029 696,-1017 679,-1009"/>
<polygon style="fill:gray;stroke:gray;" points="739.44,-1041.14 750,-1042 742.283,-1034.74 739.44,-1041.14"/>
</g>
<!-- GO:0005515&#45;&gt;GO:0032403 -->
<g id="edge945" class="edge"><title>GO:0005515&#45;&gt;GO:0032403</title>
<path style="fill:none;stroke:gray;" d="M768,-1032C768,-1024 768,-1014 768,-1006"/>
<polygon style="fill:gray;stroke:gray;" points="764.5,-1032 768,-1042 771.5,-1032 764.5,-1032"/>
</g>
<!-- GO:0019899 -->
<g id="node188" class="node"><title>GO:0019899</title>
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<text text-anchor="middle" x="877" y="-982.667" style="font-family:Arial;font-size:10px;">enzyme binding</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0019899 -->
<g id="edge407" class="edge"><title>GO:0005515&#45;&gt;GO:0019899</title>
<path style="fill:none;stroke:gray;" d="M793,-1037C802,-1032 813,-1026 823,-1020 838,-1011 854,-1000 865,-993"/>
<polygon style="fill:gray;stroke:gray;" points="791.042,-1034.08 784,-1042 794.441,-1040.2 791.042,-1034.08"/>
</g>
<!-- GO:0019838 -->
<g id="node354" class="node"><title>GO:0019838</title>
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<polygon style="fill:none;stroke:black;" points="1058,-970 1058,-1000 1120,-1000 1120,-970 1058,-970"/>
<text text-anchor="middle" x="1089" y="-989.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="1089" y="-977.667" style="font-family:Arial;font-size:10px;">binding</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0019838 -->
<g id="edge1205" class="edge"><title>GO:0005515&#45;&gt;GO:0019838</title>
<path style="fill:none;stroke:gray;" d="M813,-1047C880,-1044 1001,-1035 1041,-1020 1053,-1015 1064,-1007 1073,-1000"/>
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</g>
<!-- GO:0019955 -->
<g id="node355" class="node"><title>GO:0019955</title>
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<polygon style="fill:none;stroke:black;" points="948,-977 948,-993 1024,-993 1024,-977 948,-977"/>
<text text-anchor="middle" x="986" y="-982.667" style="font-family:Arial;font-size:10px;">cytokine binding</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0019955 -->
<g id="edge1209" class="edge"><title>GO:0005515&#45;&gt;GO:0019955</title>
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<polygon style="fill:gray;stroke:gray;" points="812.602,-1042.52 803,-1047 813.299,-1049.49 812.602,-1042.52"/>
</g>
<!-- GO:0046983 -->
<g id="node360" class="node"><title>GO:0046983</title>
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<polygon style="fill:none;stroke:black;" points="394,-970 394,-1000 484,-1000 484,-970 394,-970"/>
<text text-anchor="middle" x="439" y="-989.667" style="font-family:Arial;font-size:10px;">protein dimerization</text>
<text text-anchor="middle" x="439" y="-977.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0046983 -->
<g id="edge1241" class="edge"><title>GO:0005515&#45;&gt;GO:0046983</title>
<path style="fill:none;stroke:gray;" d="M723,-1047C658,-1042 541,-1032 501,-1020 487,-1015 472,-1007 461,-1000"/>
<polygon style="fill:gray;stroke:gray;" points="722.701,-1050.49 733,-1048 723.398,-1043.52 722.701,-1050.49"/>
</g>
<!-- GO:0005102 -->
<g id="node363" class="node"><title>GO:0005102</title>
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<polygon style="fill:none;stroke:black;" points="518,-977 518,-993 594,-993 594,-977 518,-977"/>
<text text-anchor="middle" x="556" y="-982.667" style="font-family:Arial;font-size:10px;">receptor binding</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0005102 -->
<g id="edge1255" class="edge"><title>GO:0005515&#45;&gt;GO:0005102</title>
<path style="fill:none;stroke:gray;" d="M723,-1046C691,-1041 648,-1034 611,-1020 595,-1013 577,-1001 567,-993"/>
<polygon style="fill:gray;stroke:gray;" points="722.701,-1049.49 733,-1047 723.398,-1042.52 722.701,-1049.49"/>
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<!-- GO:0007411 -->
<g id="node60" class="node"><title>GO:0007411</title>
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<text text-anchor="middle" x="7025" y="-23.6667" style="font-family:Arial;font-size:10px;">axon guidance</text>
<text text-anchor="middle" x="7025" y="-11.6667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0030307 -->
<g id="node61" class="node"><title>GO:0030307</title>
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<text text-anchor="middle" x="7211" y="-691.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="7211" y="-679.667" style="font-family:Arial;font-size:10px;">of cell growth</text>
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<text text-anchor="middle" x="7211" y="-661.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="7169,-640 7169,-656 7253,-656 7253,-640 7169,-640"/>
<text text-anchor="middle" x="7211" y="-645.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<!-- GO:0043234 -->
<g id="node62" class="node"><title>GO:0043234</title>
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<text text-anchor="middle" x="1786" y="-675.667" style="font-family:Arial;font-size:10px;">protein complex</text>
<text text-anchor="middle" x="1786" y="-663.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0043235 -->
<g id="node305" class="node"><title>GO:0043235</title>
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<text text-anchor="middle" x="1689" y="-570.667" style="font-family:Arial;font-size:10px;">receptor complex</text>
</g>
<!-- GO:0043234&#45;&gt;GO:0043235 -->
<g id="edge981" class="edge"><title>GO:0043234&#45;&gt;GO:0043235</title>
<path style="fill:none;stroke:gray;" d="M1764,-649C1742,-627 1711,-595 1697,-581"/>
<polygon style="fill:gray;stroke:gray;" points="1761.45,-651.404 1771,-656 1766.4,-646.454 1761.45,-651.404"/>
</g>
<!-- GO:0002021 -->
<g id="node63" class="node"><title>GO:0002021</title>
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<polygon style="fill:none;stroke:black;" points="7624,-780 7624,-810 7694,-810 7694,-780 7624,-780"/>
<text text-anchor="middle" x="7659" y="-799.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="7659" y="-787.667" style="font-family:Arial;font-size:10px;">dietary excess</text>
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<text text-anchor="middle" x="7659" y="-769.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="7659" y="-753.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0043627 -->
<g id="node64" class="node"><title>GO:0043627</title>
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<polygon style="fill:none;stroke:black;" points="10493,-758 10493,-800 10577,-800 10577,-758 10493,-758"/>
<text text-anchor="middle" x="10535" y="-789.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10535" y="-777.667" style="font-family:Arial;font-size:10px;">estrogen stimulus</text>
<text text-anchor="middle" x="10535" y="-765.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<text text-anchor="middle" x="5235" y="-998.667" style="font-family:Arial;font-size:10px;">cell differentiation</text>
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<g id="node154" class="node"><title>GO:0048468</title>
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<text text-anchor="middle" x="5732" y="-885.667" style="font-family:Arial;font-size:10px;">cell development</text>
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<g id="edge275" class="edge"><title>GO:0030154&#45;&gt;GO:0048468</title>
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<text text-anchor="middle" x="5436" y="-570.667" style="font-family:Arial;font-size:10px;">neuron differentiation</text>
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<!-- GO:0030154&#45;&gt;GO:0030182 -->
<g id="edge499" class="edge"><title>GO:0030154&#45;&gt;GO:0030182</title>
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<!-- GO:0045165 -->
<g id="node301" class="node"><title>GO:0045165</title>
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<text text-anchor="middle" x="5379" y="-885.667" style="font-family:Arial;font-size:10px;">cell fate commitment</text>
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<g id="edge951" class="edge"><title>GO:0030154&#45;&gt;GO:0045165</title>
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<!-- GO:0045596 -->
<g id="node321" class="node"><title>GO:0045596</title>
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<text text-anchor="middle" x="5206" y="-783.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
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<g id="edge1055" class="edge"><title>GO:0030154&#45;&gt;GO:0045596</title>
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<!-- GO:0045595 -->
<g id="node322" class="node"><title>GO:0045595</title>
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<text text-anchor="middle" x="5142" y="-892.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="5142" y="-880.667" style="font-family:Arial;font-size:10px;">cell differentiation</text>
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<!-- GO:0030154&#45;&gt;GO:0045595 -->
<g id="edge1049" class="edge"><title>GO:0030154&#45;&gt;GO:0045595</title>
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<!-- GO:0045446 -->
<g id="node324" class="node"><title>GO:0045446</title>
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<polygon style="fill:none;stroke:black;" points="4851,-873 4851,-903 4933,-903 4933,-873 4851,-873"/>
<text text-anchor="middle" x="4892" y="-892.667" style="font-family:Arial;font-size:10px;">endothelial</text>
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<g id="edge1063" class="edge"><title>GO:0030154&#45;&gt;GO:0045446</title>
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<!-- GO:0009749 -->
<g id="node66" class="node"><title>GO:0009749</title>
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<polygon style="fill:none;stroke:black;" points="10355,-574 10355,-604 10435,-604 10435,-574 10355,-574"/>
<text text-anchor="middle" x="10395" y="-593.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10395" y="-581.667" style="font-family:Arial;font-size:10px;">glucose stimulus</text>
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<text text-anchor="middle" x="10395" y="-563.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="10355,-542 10355,-558 10435,-558 10435,-542 10355,-542"/>
<text text-anchor="middle" x="10395" y="-547.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0007507 -->
<g id="node67" class="node"><title>GO:0007507</title>
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<text text-anchor="middle" x="3086" y="-792.667" style="font-family:Arial;font-size:10px;">heart development</text>
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<polygon style="fill:none;stroke:black;" points="3044,-771 3044,-787 3128,-787 3128,-771 3044,-771"/>
<text text-anchor="middle" x="3086" y="-776.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="3044,-755 3044,-771 3128,-771 3128,-755 3044,-755"/>
<text text-anchor="middle" x="3086" y="-760.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0007179 -->
<g id="node69" class="node"><title>GO:0007179</title>
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<polygon style="fill:none;stroke:black;" points="6504,-460 6504,-514 6588,-514 6588,-460 6504,-460"/>
<text text-anchor="middle" x="6546" y="-503.667" style="font-family:Arial;font-size:10px;">transforming</text>
<text text-anchor="middle" x="6546" y="-491.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="6546" y="-479.667" style="font-family:Arial;font-size:10px;">beta receptor</text>
<text text-anchor="middle" x="6546" y="-467.667" style="font-family:Arial;font-size:10px;">signaling pathway</text>
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<polygon style="fill:none;stroke:black;" points="6504,-444 6504,-460 6588,-460 6588,-444 6504,-444"/>
<text text-anchor="middle" x="6546" y="-449.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<polygon style="fill:none;stroke:black;" points="6504,-428 6504,-444 6588,-444 6588,-428 6504,-428"/>
<text text-anchor="middle" x="6546" y="-433.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<text text-anchor="middle" x="6546" y="-417.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0007476 -->
<g id="node70" class="node"><title>GO:0007476</title>
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<text text-anchor="middle" x="3490" y="-473.667" style="font-family:Arial;font-size:10px;">imaginal disc&#45;derived</text>
<text text-anchor="middle" x="3490" y="-461.667" style="font-family:Arial;font-size:10px;">wing morphogenesis</text>
<text text-anchor="middle" x="3490" y="-449.667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0042981 -->
<g id="node71" class="node"><title>GO:0042981</title>
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<polygon style="fill:none;stroke:black;" points="5365,-680 5365,-710 5431,-710 5431,-680 5365,-680"/>
<text text-anchor="middle" x="5398" y="-699.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="5398" y="-687.667" style="font-family:Arial;font-size:10px;">apoptosis</text>
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<text text-anchor="middle" x="5398" y="-669.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="5398" y="-653.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="5398" y="-637.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0042981&#45;&gt;GO:0043066 -->
<g id="edge81" class="edge"><title>GO:0042981&#45;&gt;GO:0043066</title>
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</g>
<!-- GO:0042981&#45;&gt;GO:0043065 -->
<g id="edge207" class="edge"><title>GO:0042981&#45;&gt;GO:0043065</title>
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</g>
<!-- GO:0050431 -->
<g id="node72" class="node"><title>GO:0050431</title>
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<polygon style="fill:none;stroke:black;" points="998,-883 998,-925 1060,-925 1060,-883 998,-883"/>
<text text-anchor="middle" x="1029" y="-914.667" style="font-family:Arial;font-size:10px;">transforming</text>
<text text-anchor="middle" x="1029" y="-902.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="1029" y="-890.667" style="font-family:Arial;font-size:10px;">beta binding</text>
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<text text-anchor="middle" x="1029" y="-872.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="1029" y="-856.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<!-- GO:0051602 -->
<g id="node73" class="node"><title>GO:0051602</title>
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<text text-anchor="middle" x="9531" y="-995.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="9531" y="-983.667" style="font-family:Arial;font-size:10px;">electrical stimulus</text>
<text text-anchor="middle" x="9531" y="-971.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0030324 -->
<g id="node74" class="node"><title>GO:0030324</title>
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<text text-anchor="middle" x="3749" y="-675.667" style="font-family:Arial;font-size:10px;">lung development</text>
<text text-anchor="middle" x="3749" y="-663.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0004674 -->
<g id="node75" class="node"><title>GO:0004674</title>
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<text text-anchor="middle" x="97" y="-691.667" style="font-family:Arial;font-size:10px;">protein serine/threonine</text>
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<polygon style="fill:none;stroke:black;" points="43,-656 43,-672 151,-672 151,-656 43,-656"/>
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<text text-anchor="middle" x="97" y="-645.667" style="font-family:Arial;font-size:10px;">Rat</text>
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<!-- GO:0004674&#45;&gt;GO:0004703 -->
<g id="edge135" class="edge"><title>GO:0004674&#45;&gt;GO:0004703</title>
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</g>
<!-- GO:0004702 -->
<g id="node175" class="node"><title>GO:0004702</title>
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<text text-anchor="middle" x="226" y="-583.667" style="font-family:Arial;font-size:10px;">receptor signaling</text>
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<!-- GO:0004674&#45;&gt;GO:0004702 -->
<g id="edge361" class="edge"><title>GO:0004674&#45;&gt;GO:0004702</title>
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</g>
<!-- GO:0001822 -->
<g id="node76" class="node"><title>GO:0001822</title>
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<text text-anchor="middle" x="4140" y="-792.667" style="font-family:Arial;font-size:10px;">kidney development</text>
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<text text-anchor="middle" x="4140" y="-776.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="4140" y="-760.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<!-- GO:0048179 -->
<g id="node77" class="node"><title>GO:0048179</title>
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<text text-anchor="middle" x="1454" y="-491.667" style="font-family:Arial;font-size:10px;">activin receptor</text>
<text text-anchor="middle" x="1454" y="-479.667" style="font-family:Arial;font-size:10px;">complex</text>
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<text text-anchor="middle" x="1454" y="-461.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="1454" y="-445.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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</g>
<!-- GO:0009791 -->
<g id="node78" class="node"><title>GO:0009791</title>
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<text text-anchor="middle" x="3264" y="-959.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0009886 -->
<g id="node149" class="node"><title>GO:0009886</title>
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<text text-anchor="middle" x="2740" y="-880.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
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<!-- GO:0009791&#45;&gt;GO:0009886 -->
<g id="edge251" class="edge"><title>GO:0009791&#45;&gt;GO:0009886</title>
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<!-- GO:0002165 -->
<g id="node150" class="node"><title>GO:0002165</title>
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<text text-anchor="middle" x="2859" y="-892.667" style="font-family:Arial;font-size:10px;">instar larval</text>
<text text-anchor="middle" x="2859" y="-880.667" style="font-family:Arial;font-size:10px;">or pupal development</text>
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<!-- GO:0009791&#45;&gt;GO:0002165 -->
<g id="edge259" class="edge"><title>GO:0009791&#45;&gt;GO:0002165</title>
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</g>
<!-- GO:0002164 -->
<g id="node207" class="node"><title>GO:0002164</title>
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<text text-anchor="middle" x="3920" y="-885.667" style="font-family:Arial;font-size:10px;">larval development</text>
</g>
<!-- GO:0009791&#45;&gt;GO:0002164 -->
<g id="edge467" class="edge"><title>GO:0009791&#45;&gt;GO:0002164</title>
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<g id="node79" class="node"><title>GO:0046982</title>
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<text text-anchor="middle" x="439" y="-898.667" style="font-family:Arial;font-size:10px;">protein heterodimerization</text>
<text text-anchor="middle" x="439" y="-886.667" style="font-family:Arial;font-size:10px;">activity</text>
<text text-anchor="middle" x="439" y="-874.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0001666 -->
<g id="node80" class="node"><title>GO:0001666</title>
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<text text-anchor="middle" x="9636" y="-995.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="9636" y="-983.667" style="font-family:Arial;font-size:10px;">hypoxia</text>
<text text-anchor="middle" x="9636" y="-971.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0009986 -->
<g id="node81" class="node"><title>GO:0009986</title>
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<text text-anchor="middle" x="1581" y="-989.667" style="font-family:Arial;font-size:10px;">cell surface</text>
<text text-anchor="middle" x="1581" y="-977.667" style="font-family:Arial;font-size:10px;">Mouse: ISS_only</text>
</g>
<!-- GO:0048565 -->
<g id="node82" class="node"><title>GO:0048565</title>
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<polygon style="fill:none;stroke:black;" points="3598,-764 3598,-794 3674,-794 3674,-764 3598,-764"/>
<text text-anchor="middle" x="3636" y="-783.667" style="font-family:Arial;font-size:10px;">gut development</text>
<text text-anchor="middle" x="3636" y="-771.667" style="font-family:Arial;font-size:10px;">Rat</text>
</g>
<!-- GO:0005114 -->
<g id="node83" class="node"><title>GO:0005114</title>
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<text text-anchor="middle" x="564" y="-811.667" style="font-family:Arial;font-size:10px;">type II transforming</text>
<text text-anchor="middle" x="564" y="-799.667" style="font-family:Arial;font-size:10px;">growth factor</text>
<text text-anchor="middle" x="564" y="-787.667" style="font-family:Arial;font-size:10px;">beta receptor</text>
<text text-anchor="middle" x="564" y="-775.667" style="font-family:Arial;font-size:10px;">binding</text>
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<text text-anchor="middle" x="564" y="-757.667" style="font-family:Arial;font-size:10px;">Human</text>
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<polygon style="fill:none;stroke:black;" points="520,-736 520,-752 608,-752 608,-736 520,-736"/>
<text text-anchor="middle" x="564" y="-741.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0045885 -->
<g id="node84" class="node"><title>GO:0045885</title>
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<polygon style="fill:none;stroke:black;" points="6736,-214 6736,-268 6820,-268 6820,-214 6736,-214"/>
<text text-anchor="middle" x="6778" y="-257.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6778" y="-245.667" style="font-family:Arial;font-size:10px;">of survival</text>
<text text-anchor="middle" x="6778" y="-233.667" style="font-family:Arial;font-size:10px;">gene product</text>
<text text-anchor="middle" x="6778" y="-221.667" style="font-family:Arial;font-size:10px;">expression</text>
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<polygon style="fill:none;stroke:black;" points="6736,-198 6736,-214 6820,-214 6820,-198 6736,-198"/>
<text text-anchor="middle" x="6778" y="-203.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="6778" y="-187.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
</g>
<!-- GO:0048538 -->
<g id="node85" class="node"><title>GO:0048538</title>
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<polygon style="fill:none;stroke:black;" points="4342,-679 4342,-695 4438,-695 4438,-679 4342,-679"/>
<text text-anchor="middle" x="4390" y="-684.667" style="font-family:Arial;font-size:10px;">thymus development</text>
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<polygon style="fill:none;stroke:black;" points="4342,-663 4342,-679 4438,-679 4438,-663 4342,-663"/>
<text text-anchor="middle" x="4390" y="-668.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="4342,-647 4342,-663 4438,-663 4438,-647 4342,-647"/>
<text text-anchor="middle" x="4390" y="-652.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0016319 -->
<g id="node86" class="node"><title>GO:0016319</title>
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<polygon style="fill:none;stroke:black;" points="2449,-552 2449,-594 2525,-594 2525,-552 2449,-552"/>
<text text-anchor="middle" x="2487" y="-583.667" style="font-family:Arial;font-size:10px;">mushroom body</text>
<text text-anchor="middle" x="2487" y="-571.667" style="font-family:Arial;font-size:10px;">development</text>
<text text-anchor="middle" x="2487" y="-559.667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0060037 -->
<g id="node87" class="node"><title>GO:0060037</title>
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<polygon style="fill:none;stroke:black;" points="4686,-672 4686,-702 4774,-702 4774,-672 4686,-672"/>
<text text-anchor="middle" x="4730" y="-691.667" style="font-family:Arial;font-size:10px;">pharyngeal system</text>
<text text-anchor="middle" x="4730" y="-679.667" style="font-family:Arial;font-size:10px;">development</text>
<polygon style="fill:gold;stroke:gold;" points="4686,-656 4686,-672 4774,-672 4774,-656 4686,-656"/>
<polygon style="fill:none;stroke:black;" points="4686,-656 4686,-672 4774,-672 4774,-656 4686,-656"/>
<text text-anchor="middle" x="4730" y="-661.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<polygon style="fill:none;stroke:black;" points="4686,-640 4686,-656 4774,-656 4774,-640 4686,-640"/>
<text text-anchor="middle" x="4730" y="-645.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0032924 -->
<g id="node88" class="node"><title>GO:0032924</title>
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<polygon style="fill:none;stroke:black;" points="6386,-442 6386,-484 6470,-484 6470,-442 6386,-442"/>
<text text-anchor="middle" x="6428" y="-473.667" style="font-family:Arial;font-size:10px;">activin receptor</text>
<text text-anchor="middle" x="6428" y="-461.667" style="font-family:Arial;font-size:10px;">signaling pathway</text>
<text text-anchor="middle" x="6428" y="-449.667" style="font-family:Arial;font-size:10px;">Fly</text>
</g>
<!-- GO:0006355 -->
<g id="node271" class="node"><title>GO:0006355</title>
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<polygon style="fill:none;stroke:black;" points="8793,-442 8793,-484 8867,-484 8867,-442 8793,-442"/>
<text text-anchor="middle" x="8830" y="-473.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="8830" y="-461.667" style="font-family:Arial;font-size:10px;">transcription,</text>
<text text-anchor="middle" x="8830" y="-449.667" style="font-family:Arial;font-size:10px;">DNA&#45;dependent</text>
</g>
<!-- GO:0045449&#45;&gt;GO:0006355 -->
<g id="edge757" class="edge"><title>GO:0045449&#45;&gt;GO:0006355</title>
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</g>
<!-- GO:0045941 -->
<g id="node291" class="node"><title>GO:0045941</title>
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<polygon style="fill:none;stroke:black;" points="8675,-448 8675,-478 8759,-478 8759,-448 8675,-448"/>
<text text-anchor="middle" x="8717" y="-467.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8717" y="-455.667" style="font-family:Arial;font-size:10px;">of transcription</text>
</g>
<!-- GO:0045449&#45;&gt;GO:0045941 -->
<g id="edge917" class="edge"><title>GO:0045449&#45;&gt;GO:0045941</title>
<path style="fill:none;stroke:gray;" d="M8807,-537C8797,-532 8786,-525 8776,-518 8760,-506 8743,-490 8732,-478"/>
<polygon style="fill:gray;stroke:gray;" points="8805.56,-540.203 8816,-542 8808.96,-534.084 8805.56,-540.203"/>
</g>
<!-- GO:0048514 -->
<g id="node90" class="node"><title>GO:0048514</title>
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<polygon style="fill:none;stroke:black;" points="1977,-558 1977,-588 2049,-588 2049,-558 1977,-558"/>
<text text-anchor="middle" x="2013" y="-577.667" style="font-family:Arial;font-size:10px;">blood vessel</text>
<text text-anchor="middle" x="2013" y="-565.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
</g>
<!-- GO:0048514&#45;&gt;GO:0048844 -->
<g id="edge3" class="edge"><title>GO:0048514&#45;&gt;GO:0048844</title>
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</g>
<!-- GO:0009887 -->
<g id="node91" class="node"><title>GO:0009887</title>
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<polygon style="fill:none;stroke:black;" points="2050,-771 2050,-787 2150,-787 2150,-771 2050,-771"/>
<text text-anchor="middle" x="2100" y="-776.667" style="font-family:Arial;font-size:10px;">organ morphogenesis</text>
</g>
<!-- GO:0009887&#45;&gt;GO:0031100 -->
<g id="edge531" class="edge"><title>GO:0009887&#45;&gt;GO:0031100</title>
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</g>
<!-- GO:0009887&#45;&gt;GO:0048705 -->
<g id="edge297" class="edge"><title>GO:0009887&#45;&gt;GO:0048705</title>
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</g>
<!-- GO:0009887&#45;&gt;GO:0048514 -->
<g id="edge5" class="edge"><title>GO:0009887&#45;&gt;GO:0048514</title>
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<polygon style="fill:gray;stroke:gray;" points="2065.44,-770.137 2076,-771 2068.28,-763.74 2065.44,-770.137"/>
</g>
<!-- GO:0007560 -->
<g id="node145" class="node"><title>GO:0007560</title>
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<polygon style="fill:none;stroke:black;" points="2564,-656 2564,-686 2636,-686 2636,-656 2564,-656"/>
<text text-anchor="middle" x="2600" y="-675.667" style="font-family:Arial;font-size:10px;">imaginal disc</text>
<text text-anchor="middle" x="2600" y="-663.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
</g>
<!-- GO:0009887&#45;&gt;GO:0007560 -->
<g id="edge235" class="edge"><title>GO:0009887&#45;&gt;GO:0007560</title>
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</g>
<!-- GO:0009653 -->
<g id="node92" class="node"><title>GO:0009653</title>
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<polygon style="fill:none;stroke:black;" points="2856,-970 2856,-1000 2950,-1000 2950,-970 2856,-970"/>
<text text-anchor="middle" x="2903" y="-989.667" style="font-family:Arial;font-size:10px;">anatomical structure</text>
<text text-anchor="middle" x="2903" y="-977.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
</g>
<!-- GO:0009653&#45;&gt;GO:0009887 -->
<g id="edge7" class="edge"><title>GO:0009653&#45;&gt;GO:0009887</title>
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</g>
<!-- GO:0007552 -->
<g id="node147" class="node"><title>GO:0007552</title>
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<polygon style="fill:none;stroke:black;" points="2426,-771 2426,-787 2498,-787 2498,-771 2426,-771"/>
<text text-anchor="middle" x="2462" y="-776.667" style="font-family:Arial;font-size:10px;">metamorphosis</text>
</g>
<!-- GO:0009653&#45;&gt;GO:0007552 -->
<g id="edge243" class="edge"><title>GO:0009653&#45;&gt;GO:0007552</title>
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</g>
<!-- GO:0009653&#45;&gt;GO:0009886 -->
<g id="edge249" class="edge"><title>GO:0009653&#45;&gt;GO:0009886</title>
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</g>
<!-- GO:0009653&#45;&gt;GO:0048598 -->
<g id="edge291" class="edge"><title>GO:0009653&#45;&gt;GO:0048598</title>
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<polygon style="fill:gray;stroke:gray;" points="2845.51,-978.471 2856,-977 2846.88,-971.607 2845.51,-978.471"/>
</g>
<!-- GO:0031099 -->
<g id="node222" class="node"><title>GO:0031099</title>
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<polygon style="fill:none;stroke:black;" points="1895,-771 1895,-787 1955,-787 1955,-771 1895,-771"/>
<text text-anchor="middle" x="1925" y="-776.667" style="font-family:Arial;font-size:10px;">regeneration</text>
</g>
<!-- GO:0009653&#45;&gt;GO:0031099 -->
<g id="edge535" class="edge"><title>GO:0009653&#45;&gt;GO:0031099</title>
<path style="fill:none;stroke:gray;" d="M2846,-984C2699,-978 2301,-952 2000,-826 1976,-815 1950,-797 1936,-787"/>
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</g>
<!-- GO:0022603 -->
<g id="node260" class="node"><title>GO:0022603</title>
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<g id="edge89" class="edge"><title>GO:0032502&#45;&gt;GO:0050793</title>
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<g id="edge1225" class="edge"><title>GO:0048513&#45;&gt;GO:0030323</title>
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<g id="edge1269" class="edge"><title>GO:0048513&#45;&gt;GO:0048534</title>
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<!-- GO:0048513&#45;&gt;GO:0007420 -->
<g id="edge1283" class="edge"><title>GO:0048513&#45;&gt;GO:0007420</title>
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<g id="edge301" class="edge"><title>GO:0048731&#45;&gt;GO:0001501</title>
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<g id="edge21" class="edge"><title>GO:0048731&#45;&gt;GO:0048513</title>
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<g id="edge45" class="edge"><title>GO:0048731&#45;&gt;GO:0035270</title>
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<g id="edge285" class="edge"><title>GO:0048731&#45;&gt;GO:0007399</title>
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<g id="edge1277" class="edge"><title>GO:0048731&#45;&gt;GO:0002520</title>
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<g id="edge1287" class="edge"><title>GO:0048731&#45;&gt;GO:0007417</title>
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<g id="edge161" class="edge"><title>GO:0007275&#45;&gt;GO:0009790</title>
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<g id="edge25" class="edge"><title>GO:0007275&#45;&gt;GO:0048731</title>
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<g id="edge1147" class="edge"><title>GO:0032501&#45;&gt;GO:0051239</title>
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<g id="edge47" class="edge"><title>GO:0042127&#45;&gt;GO:0008284</title>
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<!-- GO:0050794&#45;&gt;GO:0048522 -->
<g id="edge75" class="edge"><title>GO:0050794&#45;&gt;GO:0048522</title>
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<text text-anchor="middle" x="5619" y="-777.667" style="font-family:Arial;font-size:10px;">programmed cell</text>
<text text-anchor="middle" x="5619" y="-765.667" style="font-family:Arial;font-size:10px;">death</text>
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<!-- GO:0050794&#45;&gt;GO:0043067 -->
<g id="edge91" class="edge"><title>GO:0050794&#45;&gt;GO:0043067</title>
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<g id="edge119" class="edge"><title>GO:0050794&#45;&gt;GO:0048523</title>
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<text text-anchor="middle" x="6498" y="-892.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0050794&#45;&gt;GO:0051726 -->
<g id="edge453" class="edge"><title>GO:0050794&#45;&gt;GO:0051726</title>
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<!-- GO:0010646 -->
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<!-- GO:0050794&#45;&gt;GO:0010646 -->
<g id="edge547" class="edge"><title>GO:0050794&#45;&gt;GO:0010646</title>
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<g id="node261" class="node"><title>GO:0051128</title>
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<text text-anchor="middle" x="3340" y="-898.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0050794&#45;&gt;GO:0051128 -->
<g id="edge709" class="edge"><title>GO:0050794&#45;&gt;GO:0051128</title>
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<g id="node277" class="node"><title>GO:0031323</title>
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<text text-anchor="middle" x="8425" y="-898.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<text text-anchor="middle" x="8425" y="-874.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0050794&#45;&gt;GO:0031323 -->
<g id="edge785" class="edge"><title>GO:0050794&#45;&gt;GO:0031323</title>
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<!-- GO:0051270 -->
<g id="node304" class="node"><title>GO:0051270</title>
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<text text-anchor="middle" x="7602" y="-880.667" style="font-family:Arial;font-size:10px;">cell motion</text>
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<!-- GO:0050794&#45;&gt;GO:0051270 -->
<g id="edge973" class="edge"><title>GO:0050794&#45;&gt;GO:0051270</title>
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<!-- GO:0050794&#45;&gt;GO:0045595 -->
<g id="edge1047" class="edge"><title>GO:0050794&#45;&gt;GO:0045595</title>
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<!-- GO:0001558 -->
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<text text-anchor="middle" x="7211" y="-771.667" style="font-family:Arial;font-size:10px;">cell growth</text>
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<!-- GO:0050794&#45;&gt;GO:0001558 -->
<g id="edge1107" class="edge"><title>GO:0050794&#45;&gt;GO:0001558</title>
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<!-- GO:0050789&#45;&gt;GO:0050794 -->
<g id="edge51" class="edge"><title>GO:0050789&#45;&gt;GO:0050794</title>
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<!-- GO:0050789&#45;&gt;GO:0048518 -->
<g id="edge71" class="edge"><title>GO:0050789&#45;&gt;GO:0048518</title>
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<!-- GO:0050789&#45;&gt;GO:0050793 -->
<g id="edge87" class="edge"><title>GO:0050789&#45;&gt;GO:0050793</title>
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<g id="edge115" class="edge"><title>GO:0050789&#45;&gt;GO:0048519</title>
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<!-- GO:0019222 -->
<g id="node133" class="node"><title>GO:0019222</title>
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<text text-anchor="middle" x="8281" y="-989.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0050789&#45;&gt;GO:0019222 -->
<g id="edge175" class="edge"><title>GO:0050789&#45;&gt;GO:0019222</title>
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<!-- GO:0032879 -->
<g id="node238" class="node"><title>GO:0032879</title>
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<text text-anchor="middle" x="7779" y="-989.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0050789&#45;&gt;GO:0032879 -->
<g id="edge601" class="edge"><title>GO:0050789&#45;&gt;GO:0032879</title>
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<!-- GO:0040008 -->
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<text text-anchor="middle" x="7097" y="-977.667" style="font-family:Arial;font-size:10px;">growth</text>
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<!-- GO:0050789&#45;&gt;GO:0040008 -->
<g id="edge1103" class="edge"><title>GO:0050789&#45;&gt;GO:0040008</title>
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<g id="edge1145" class="edge"><title>GO:0050789&#45;&gt;GO:0051239</title>
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<g id="edge53" class="edge"><title>GO:0065007&#45;&gt;GO:0050789</title>
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<g id="node196" class="node"><title>GO:0065009</title>
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<text text-anchor="middle" x="7135" y="-1078.67" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="7135" y="-1066.67" style="font-family:Arial;font-size:10px;">molecular function</text>
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<!-- GO:0065007&#45;&gt;GO:0065009 -->
<g id="edge429" class="edge"><title>GO:0065007&#45;&gt;GO:0065009</title>
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<g id="node253" class="node"><title>GO:0065008</title>
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<text text-anchor="middle" x="7463" y="-1078.67" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0065007&#45;&gt;GO:0065008 -->
<g id="edge667" class="edge"><title>GO:0065007&#45;&gt;GO:0065008</title>
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<g id="edge59" class="edge"><title>GO:0009987&#45;&gt;GO:0050794</title>
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<!-- GO:0009987&#45;&gt;GO:0008283 -->
<g id="edge65" class="edge"><title>GO:0009987&#45;&gt;GO:0008283</title>
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<g id="edge77" class="edge"><title>GO:0009987&#45;&gt;GO:0048522</title>
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<!-- GO:0009987&#45;&gt;GO:0008219 -->
<g id="edge97" class="edge"><title>GO:0009987&#45;&gt;GO:0008219</title>
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<g id="edge121" class="edge"><title>GO:0009987&#45;&gt;GO:0048523</title>
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<!-- GO:0009987&#45;&gt;GO:0007154 -->
<g id="edge215" class="edge"><title>GO:0009987&#45;&gt;GO:0007154</title>
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<g id="edge273" class="edge"><title>GO:0009987&#45;&gt;GO:0048468</title>
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<g id="edge279" class="edge"><title>GO:0009987&#45;&gt;GO:0048869</title>
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<text text-anchor="middle" x="8379" y="-1078.67" style="font-family:Arial;font-size:10px;">cellular metabolic</text>
<text text-anchor="middle" x="8379" y="-1066.67" style="font-family:Arial;font-size:10px;">process</text>
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<g id="edge319" class="edge"><title>GO:0009987&#45;&gt;GO:0044237</title>
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<!-- GO:0009987&#45;&gt;GO:0007049 -->
<g id="edge457" class="edge"><title>GO:0009987&#45;&gt;GO:0007049</title>
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<!-- GO:0009987&#45;&gt;GO:0016043 -->
<g id="edge475" class="edge"><title>GO:0009987&#45;&gt;GO:0016043</title>
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<!-- GO:0009987&#45;&gt;GO:0006928 -->
<g id="edge483" class="edge"><title>GO:0009987&#45;&gt;GO:0006928</title>
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<text text-anchor="middle" x="9660" y="-904.667" style="font-family:Arial;font-size:10px;">generation of</text>
<text text-anchor="middle" x="9660" y="-892.667" style="font-family:Arial;font-size:10px;">a signal involved</text>
<text text-anchor="middle" x="9660" y="-880.667" style="font-family:Arial;font-size:10px;">in cell&#45;cell</text>
<text text-anchor="middle" x="9660" y="-868.667" style="font-family:Arial;font-size:10px;">signaling</text>
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<!-- GO:0009987&#45;&gt;GO:0003001 -->
<g id="edge653" class="edge"><title>GO:0009987&#45;&gt;GO:0003001</title>
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<g id="edge949" class="edge"><title>GO:0009987&#45;&gt;GO:0045165</title>
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<!-- GO:0016049 -->
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<text text-anchor="middle" x="7325" y="-885.667" style="font-family:Arial;font-size:10px;">cell growth</text>
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<!-- GO:0009987&#45;&gt;GO:0016049 -->
<g id="edge1111" class="edge"><title>GO:0009987&#45;&gt;GO:0016049</title>
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<!-- GO:0008283&#45;&gt;GO:0008284 -->
<g id="edge79" class="edge"><title>GO:0008283&#45;&gt;GO:0008284</title>
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<!-- GO:0008283&#45;&gt;GO:0007405 -->
<g id="edge265" class="edge"><title>GO:0008283&#45;&gt;GO:0007405</title>
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<!-- GO:0008283&#45;&gt;GO:0001834 -->
<g id="edge1021" class="edge"><title>GO:0008283&#45;&gt;GO:0001834</title>
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<!-- GO:0008283&#45;&gt;GO:0042127 -->
<g id="edge63" class="edge"><title>GO:0008283&#45;&gt;GO:0042127</title>
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<!-- GO:0048522&#45;&gt;GO:0008284 -->
<g id="edge67" class="edge"><title>GO:0048522&#45;&gt;GO:0008284</title>
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<!-- GO:0048522&#45;&gt;GO:0051272 -->
<g id="edge967" class="edge"><title>GO:0048522&#45;&gt;GO:0051272</title>
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<!-- GO:0048522&#45;&gt;GO:0030307 -->
<g id="edge1127" class="edge"><title>GO:0048522&#45;&gt;GO:0030307</title>
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<g id="node137" class="node"><title>GO:0043068</title>
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<text text-anchor="middle" x="5175" y="-681.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="5175" y="-669.667" style="font-family:Arial;font-size:10px;">of programmed</text>
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<!-- GO:0048522&#45;&gt;GO:0043068 -->
<g id="edge193" class="edge"><title>GO:0048522&#45;&gt;GO:0043068</title>
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<text text-anchor="middle" x="6526" y="-783.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6526" y="-771.667" style="font-family:Arial;font-size:10px;">of cell communication</text>
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<!-- GO:0048522&#45;&gt;GO:0010647 -->
<g id="edge557" class="edge"><title>GO:0048522&#45;&gt;GO:0010647</title>
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<!-- GO:0051130 -->
<g id="node265" class="node"><title>GO:0051130</title>
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<text text-anchor="middle" x="3353" y="-789.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="3353" y="-777.667" style="font-family:Arial;font-size:10px;">of cellular</text>
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<!-- GO:0048522&#45;&gt;GO:0051130 -->
<g id="edge731" class="edge"><title>GO:0048522&#45;&gt;GO:0051130</title>
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<g id="node298" class="node"><title>GO:0031325</title>
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<text text-anchor="middle" x="8341" y="-789.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8341" y="-777.667" style="font-family:Arial;font-size:10px;">of cellular</text>
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<!-- GO:0048522&#45;&gt;GO:0031325 -->
<g id="edge909" class="edge"><title>GO:0048522&#45;&gt;GO:0031325</title>
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<g id="edge69" class="edge"><title>GO:0048518&#45;&gt;GO:0048522</title>
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<g id="edge197" class="edge"><title>GO:0048518&#45;&gt;GO:0051094</title>
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<text text-anchor="middle" x="8270" y="-898.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8270" y="-886.667" style="font-family:Arial;font-size:10px;">of metabolic</text>
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<!-- GO:0048518&#45;&gt;GO:0009893 -->
<g id="edge873" class="edge"><title>GO:0048518&#45;&gt;GO:0009893</title>
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<!-- GO:0045927 -->
<g id="node336" class="node"><title>GO:0045927</title>
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<g id="edge1123" class="edge"><title>GO:0048518&#45;&gt;GO:0045927</title>
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<g id="edge83" class="edge"><title>GO:0043067&#45;&gt;GO:0042981</title>
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<g id="edge109" class="edge"><title>GO:0043067&#45;&gt;GO:0043069</title>
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<g id="edge191" class="edge"><title>GO:0043067&#45;&gt;GO:0043068</title>
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<g id="edge85" class="edge"><title>GO:0050793&#45;&gt;GO:0043067</title>
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<g id="edge127" class="edge"><title>GO:0050793&#45;&gt;GO:0051093</title>
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<g id="edge199" class="edge"><title>GO:0050793&#45;&gt;GO:0051094</title>
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<g id="edge703" class="edge"><title>GO:0050793&#45;&gt;GO:0022603</title>
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<g id="edge1045" class="edge"><title>GO:0050793&#45;&gt;GO:0045595</title>
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<!-- GO:0012501&#45;&gt;GO:0043067 -->
<g id="edge93" class="edge"><title>GO:0012501&#45;&gt;GO:0043067</title>
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<!-- GO:0012501&#45;&gt;GO:0006915 -->
<g id="edge105" class="edge"><title>GO:0012501&#45;&gt;GO:0006915</title>
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<g id="edge131" class="edge"><title>GO:0012501&#45;&gt;GO:0043069</title>
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<g id="edge203" class="edge"><title>GO:0012501&#45;&gt;GO:0043068</title>
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<g id="edge95" class="edge"><title>GO:0008219&#45;&gt;GO:0012501</title>
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<!-- GO:0016265&#45;&gt;GO:0008219 -->
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<!-- GO:0006915&#45;&gt;GO:0043066 -->
<g id="edge133" class="edge"><title>GO:0006915&#45;&gt;GO:0043066</title>
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<!-- GO:0006915&#45;&gt;GO:0043065 -->
<g id="edge211" class="edge"><title>GO:0006915&#45;&gt;GO:0043065</title>
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<!-- GO:0006915&#45;&gt;GO:0042981 -->
<g id="edge103" class="edge"><title>GO:0006915&#45;&gt;GO:0042981</title>
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<!-- GO:0043069&#45;&gt;GO:0043066 -->
<g id="edge107" class="edge"><title>GO:0043069&#45;&gt;GO:0043066</title>
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<!-- GO:0048523&#45;&gt;GO:0043069 -->
<g id="edge111" class="edge"><title>GO:0048523&#45;&gt;GO:0043069</title>
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<!-- GO:0046888 -->
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<polygon style="fill:none;stroke:black;" points="9692,-558 9692,-588 9788,-588 9788,-558 9692,-558"/>
<text text-anchor="middle" x="9740" y="-577.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="9740" y="-565.667" style="font-family:Arial;font-size:10px;">of hormone secretion</text>
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<!-- GO:0048523&#45;&gt;GO:0046888 -->
<g id="edge671" class="edge"><title>GO:0048523&#45;&gt;GO:0046888</title>
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<!-- GO:0048523&#45;&gt;GO:0045596 -->
<g id="edge1051" class="edge"><title>GO:0048523&#45;&gt;GO:0045596</title>
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<!-- GO:0048519&#45;&gt;GO:0048523 -->
<g id="edge113" class="edge"><title>GO:0048519&#45;&gt;GO:0048523</title>
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<polygon style="fill:gray;stroke:gray;" points="6125.78,-958.779 6135,-964 6131.05,-954.169 6125.78,-958.779"/>
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<!-- GO:0048519&#45;&gt;GO:0051093 -->
<g id="edge125" class="edge"><title>GO:0048519&#45;&gt;GO:0051093</title>
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<!-- GO:0051051 -->
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<polygon style="fill:none;stroke:black;" points="9669,-764 9669,-794 9755,-794 9755,-764 9669,-764"/>
<text text-anchor="middle" x="9712" y="-783.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="9712" y="-771.667" style="font-family:Arial;font-size:10px;">of transport</text>
</g>
<!-- GO:0048519&#45;&gt;GO:0051051 -->
<g id="edge631" class="edge"><title>GO:0048519&#45;&gt;GO:0051051</title>
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<!-- GO:0051093&#45;&gt;GO:0043069 -->
<g id="edge123" class="edge"><title>GO:0051093&#45;&gt;GO:0043069</title>
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</g>
<!-- GO:0051093&#45;&gt;GO:0045596 -->
<g id="edge1053" class="edge"><title>GO:0051093&#45;&gt;GO:0045596</title>
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<!-- GO:0004672 -->
<g id="node121" class="node"><title>GO:0004672</title>
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<polygon style="fill:none;stroke:black;" points="88,-764 88,-794 154,-794 154,-764 88,-764"/>
<text text-anchor="middle" x="121" y="-783.667" style="font-family:Arial;font-size:10px;">protein kinase</text>
<text text-anchor="middle" x="121" y="-771.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0004672&#45;&gt;GO:0004674 -->
<g id="edge137" class="edge"><title>GO:0004672&#45;&gt;GO:0004674</title>
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<polygon style="fill:gray;stroke:gray;" points="110.774,-755.427 117,-764 117.479,-753.416 110.774,-755.427"/>
</g>
<!-- GO:0019199 -->
<g id="node179" class="node"><title>GO:0019199</title>
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<polygon style="fill:none;stroke:black;" points="301,-650 301,-692 375,-692 375,-650 301,-650"/>
<text text-anchor="middle" x="338" y="-681.667" style="font-family:Arial;font-size:10px;">transmembrane</text>
<text text-anchor="middle" x="338" y="-669.667" style="font-family:Arial;font-size:10px;">receptor protein</text>
<text text-anchor="middle" x="338" y="-657.667" style="font-family:Arial;font-size:10px;">kinase activity</text>
</g>
<!-- GO:0004672&#45;&gt;GO:0019199 -->
<g id="edge373" class="edge"><title>GO:0004672&#45;&gt;GO:0019199</title>
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</g>
<!-- GO:0016301 -->
<g id="node122" class="node"><title>GO:0016301</title>
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<polygon style="fill:none;stroke:black;" points="8,-880 8,-896 76,-896 76,-880 8,-880"/>
<text text-anchor="middle" x="42" y="-885.667" style="font-family:Arial;font-size:10px;">kinase activity</text>
</g>
<!-- GO:0016301&#45;&gt;GO:0004672 -->
<g id="edge139" class="edge"><title>GO:0016301&#45;&gt;GO:0004672</title>
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<polygon style="fill:gray;stroke:gray;" points="51.2,-869.9 48,-880 56.8,-874.1 51.2,-869.9"/>
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<!-- GO:0016772 -->
<g id="node123" class="node"><title>GO:0016772</title>
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<polygon style="fill:none;stroke:black;" points="103,-958 103,-1012 207,-1012 207,-958 103,-958"/>
<text text-anchor="middle" x="155" y="-1001.67" style="font-family:Arial;font-size:10px;">transferase</text>
<text text-anchor="middle" x="155" y="-989.667" style="font-family:Arial;font-size:10px;">activity, transferring</text>
<text text-anchor="middle" x="155" y="-977.667" style="font-family:Arial;font-size:10px;">phosphorus&#45;containing</text>
<text text-anchor="middle" x="155" y="-965.667" style="font-family:Arial;font-size:10px;">groups</text>
</g>
<!-- GO:0016772&#45;&gt;GO:0016301 -->
<g id="edge141" class="edge"><title>GO:0016772&#45;&gt;GO:0016301</title>
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<polygon style="fill:none;stroke:black;" points="110,-867 110,-909 200,-909 200,-867 110,-867"/>
<text text-anchor="middle" x="155" y="-898.667" style="font-family:Arial;font-size:10px;">phosphotransferase</text>
<text text-anchor="middle" x="155" y="-886.667" style="font-family:Arial;font-size:10px;">activity, alcohol</text>
<text text-anchor="middle" x="155" y="-874.667" style="font-family:Arial;font-size:10px;">group as acceptor</text>
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<!-- GO:0016772&#45;&gt;GO:0016773 -->
<g id="edge151" class="edge"><title>GO:0016772&#45;&gt;GO:0016773</title>
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<g id="node124" class="node"><title>GO:0016740</title>
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<polygon style="fill:none;stroke:black;" points="133,-1059 133,-1089 187,-1089 187,-1059 133,-1059"/>
<text text-anchor="middle" x="160" y="-1078.67" style="font-family:Arial;font-size:10px;">transferase</text>
<text text-anchor="middle" x="160" y="-1066.67" style="font-family:Arial;font-size:10px;">activity</text>
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<!-- GO:0016740&#45;&gt;GO:0016772 -->
<g id="edge143" class="edge"><title>GO:0016740&#45;&gt;GO:0016772</title>
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<!-- GO:0003824&#45;&gt;GO:0016740 -->
<g id="edge145" class="edge"><title>GO:0003824&#45;&gt;GO:0016740</title>
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<!-- GO:0016773&#45;&gt;GO:0004672 -->
<g id="edge149" class="edge"><title>GO:0016773&#45;&gt;GO:0004672</title>
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<!-- GO:0043009 -->
<g id="node127" class="node"><title>GO:0043009</title>
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<polygon style="fill:none;stroke:black;" points="4606,-764 4606,-794 4698,-794 4698,-764 4606,-764"/>
<text text-anchor="middle" x="4652" y="-783.667" style="font-family:Arial;font-size:10px;">chordate embryonic</text>
<text text-anchor="middle" x="4652" y="-771.667" style="font-family:Arial;font-size:10px;">development</text>
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<!-- GO:0043009&#45;&gt;GO:0001701 -->
<g id="edge153" class="edge"><title>GO:0043009&#45;&gt;GO:0001701</title>
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<!-- GO:0043009&#45;&gt;GO:0060037 -->
<g id="edge1293" class="edge"><title>GO:0043009&#45;&gt;GO:0060037</title>
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<!-- GO:0043009&#45;&gt;GO:0048706 -->
<g id="edge307" class="edge"><title>GO:0043009&#45;&gt;GO:0048706</title>
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<g id="edge155" class="edge"><title>GO:0009792&#45;&gt;GO:0043009</title>
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<text text-anchor="middle" x="9516" y="-892.667" style="font-family:Arial;font-size:10px;">lipid metabolic</text>
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<!-- GO:0006629&#45;&gt;GO:0019915 -->
<g id="edge163" class="edge"><title>GO:0006629&#45;&gt;GO:0019915</title>
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<g id="node130" class="node"><title>GO:0044238</title>
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<polygon style="fill:none;stroke:black;" points="8622,-970 8622,-1000 8706,-1000 8706,-970 8622,-970"/>
<text text-anchor="middle" x="8664" y="-989.667" style="font-family:Arial;font-size:10px;">primary metabolic</text>
<text text-anchor="middle" x="8664" y="-977.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0044238&#45;&gt;GO:0006629 -->
<g id="edge165" class="edge"><title>GO:0044238&#45;&gt;GO:0006629</title>
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<text text-anchor="middle" x="8034" y="-880.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0044238&#45;&gt;GO:0019538 -->
<g id="edge337" class="edge"><title>GO:0044238&#45;&gt;GO:0019538</title>
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<text text-anchor="middle" x="8665" y="-910.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
<text text-anchor="middle" x="8665" y="-898.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="8665" y="-886.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
<text text-anchor="middle" x="8665" y="-874.667" style="font-family:Arial;font-size:10px;">nucleic acid</text>
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<!-- GO:0044238&#45;&gt;GO:0006139 -->
<g id="edge793" class="edge"><title>GO:0044238&#45;&gt;GO:0006139</title>
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<!-- GO:0008152&#45;&gt;GO:0044238 -->
<g id="edge167" class="edge"><title>GO:0008152&#45;&gt;GO:0044238</title>
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<g id="edge177" class="edge"><title>GO:0008152&#45;&gt;GO:0019222</title>
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<g id="edge171" class="edge"><title>GO:0060255&#45;&gt;GO:0010468</title>
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<g id="edge835" class="edge"><title>GO:0060255&#45;&gt;GO:0051252</title>
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<!-- GO:0060255&#45;&gt;GO:0010604 -->
<g id="edge885" class="edge"><title>GO:0060255&#45;&gt;GO:0010604</title>
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<g id="edge173" class="edge"><title>GO:0019222&#45;&gt;GO:0060255</title>
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<!-- GO:0009889 -->
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<g id="edge765" class="edge"><title>GO:0019222&#45;&gt;GO:0009889</title>
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<g id="edge783" class="edge"><title>GO:0019222&#45;&gt;GO:0031323</title>
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<g id="edge871" class="edge"><title>GO:0019222&#45;&gt;GO:0009893</title>
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<g id="edge179" class="edge"><title>GO:0043170&#45;&gt;GO:0060255</title>
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<!-- GO:0043170&#45;&gt;GO:0010467 -->
<g id="edge185" class="edge"><title>GO:0043170&#45;&gt;GO:0010467</title>
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<!-- GO:0043170&#45;&gt;GO:0043283 -->
<g id="edge329" class="edge"><title>GO:0043170&#45;&gt;GO:0043283</title>
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<!-- GO:0043170&#45;&gt;GO:0044260 -->
<g id="edge345" class="edge"><title>GO:0043170&#45;&gt;GO:0044260</title>
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<!-- GO:0043170&#45;&gt;GO:0009059 -->
<g id="edge777" class="edge"><title>GO:0043170&#45;&gt;GO:0009059</title>
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<g id="edge887" class="edge"><title>GO:0043170&#45;&gt;GO:0010604</title>
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<g id="edge183" class="edge"><title>GO:0010467&#45;&gt;GO:0010468</title>
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<!-- GO:0010467&#45;&gt;GO:0006350 -->
<g id="edge829" class="edge"><title>GO:0010467&#45;&gt;GO:0006350</title>
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<g id="edge897" class="edge"><title>GO:0010467&#45;&gt;GO:0010628</title>
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<g id="edge209" class="edge"><title>GO:0043068&#45;&gt;GO:0043065</title>
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<g id="edge189" class="edge"><title>GO:0043068&#45;&gt;GO:0012502</title>
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<g id="edge213" class="edge"><title>GO:0007154&#45;&gt;GO:0007165</title>
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<g id="edge657" class="edge"><title>GO:0007154&#45;&gt;GO:0007267</title>
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<g id="edge219" class="edge"><title>GO:0043434&#45;&gt;GO:0032868</title>
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<g id="edge583" class="edge"><title>GO:0009725&#45;&gt;GO:0034694</title>
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<g id="edge223" class="edge"><title>GO:0009719&#45;&gt;GO:0009725</title>
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<g id="edge1137" class="edge"><title>GO:0050896&#45;&gt;GO:0002021</title>
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<g id="edge231" class="edge"><title>GO:0050896&#45;&gt;GO:0042221</title>
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<g id="edge1213" class="edge"><title>GO:0050896&#45;&gt;GO:0009628</title>
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<g id="edge1245" class="edge"><title>GO:0050896&#45;&gt;GO:0006950</title>
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<g id="edge693" class="edge"><title>GO:0042221&#45;&gt;GO:0009636</title>
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<g id="edge229" class="edge"><title>GO:0042221&#45;&gt;GO:0009725</title>
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<g id="edge589" class="edge"><title>GO:0042221&#45;&gt;GO:0010033</title>
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<g id="edge233" class="edge"><title>GO:0007560&#45;&gt;GO:0007455</title>
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<!-- GO:0007560&#45;&gt;GO:0007472 -->
<g id="edge1197" class="edge"><title>GO:0007560&#45;&gt;GO:0007472</title>
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<g id="edge237" class="edge"><title>GO:0007444&#45;&gt;GO:0007560</title>
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<g id="edge263" class="edge"><title>GO:0007444&#45;&gt;GO:0035214</title>
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<g id="edge1201" class="edge"><title>GO:0007444&#45;&gt;GO:0035220</title>
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<g id="edge241" class="edge"><title>GO:0007552&#45;&gt;GO:0007560</title>
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<!-- GO:0048707&#45;&gt;GO:0007560 -->
<g id="edge245" class="edge"><title>GO:0048707&#45;&gt;GO:0007560</title>
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<g id="edge247" class="edge"><title>GO:0009886&#45;&gt;GO:0048707</title>
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<g id="edge257" class="edge"><title>GO:0002165&#45;&gt;GO:0048707</title>
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<g id="edge267" class="edge"><title>GO:0048699&#45;&gt;GO:0007405</title>
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<g id="edge501" class="edge"><title>GO:0048699&#45;&gt;GO:0030182</title>
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<g id="edge277" class="edge"><title>GO:0048869&#45;&gt;GO:0030154</title>
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<g id="edge309" class="edge"><title>GO:0016310&#45;&gt;GO:0006468</title>
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<g id="edge311" class="edge"><title>GO:0006796&#45;&gt;GO:0016310</title>
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<g id="edge313" class="edge"><title>GO:0006793&#45;&gt;GO:0006796</title>
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<g id="edge315" class="edge"><title>GO:0044237&#45;&gt;GO:0006793</title>
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<g id="edge347" class="edge"><title>GO:0044237&#45;&gt;GO:0044260</title>
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<text text-anchor="middle" x="8995" y="-989.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
<text text-anchor="middle" x="8995" y="-977.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0044237&#45;&gt;GO:0044249 -->
<g id="edge805" class="edge"><title>GO:0044237&#45;&gt;GO:0044249</title>
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<g id="edge911" class="edge"><title>GO:0044237&#45;&gt;GO:0031325</title>
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<!-- GO:0043687&#45;&gt;GO:0006468 -->
<g id="edge321" class="edge"><title>GO:0043687&#45;&gt;GO:0006468</title>
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<g id="edge323" class="edge"><title>GO:0006464&#45;&gt;GO:0043687</title>
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<!-- GO:0043283&#45;&gt;GO:0019538 -->
<g id="edge335" class="edge"><title>GO:0043283&#45;&gt;GO:0019538</title>
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<text text-anchor="middle" x="8544" y="-892.667" style="font-family:Arial;font-size:10px;">cellular biopolymer</text>
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<!-- GO:0043283&#45;&gt;GO:0034960 -->
<g id="edge341" class="edge"><title>GO:0043283&#45;&gt;GO:0034960</title>
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<!-- GO:0043283&#45;&gt;GO:0043284 -->
<g id="edge827" class="edge"><title>GO:0043283&#45;&gt;GO:0043284</title>
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<g id="edge331" class="edge"><title>GO:0044267&#45;&gt;GO:0006464</title>
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<g id="edge333" class="edge"><title>GO:0019538&#45;&gt;GO:0044267</title>
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<text text-anchor="middle" x="9228" y="-789.667" style="font-family:Arial;font-size:10px;">cellular biopolymer</text>
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<g id="edge821" class="edge"><title>GO:0034960&#45;&gt;GO:0034961</title>
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<g id="edge841" class="edge"><title>GO:0034960&#45;&gt;GO:0016070</title>
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<g id="edge343" class="edge"><title>GO:0044260&#45;&gt;GO:0034960</title>
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<g id="edge819" class="edge"><title>GO:0044260&#45;&gt;GO:0034645</title>
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<g id="edge359" class="edge"><title>GO:0004702&#45;&gt;GO:0004675</title>
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<!-- GO:0004871 -->
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<polygon style="fill:none;stroke:black;" points="255,-970 255,-1000 335,-1000 335,-970 255,-970"/>
<text text-anchor="middle" x="295" y="-989.667" style="font-family:Arial;font-size:10px;">signal transducer</text>
<text text-anchor="middle" x="295" y="-977.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0004871&#45;&gt;GO:0005057 -->
<g id="edge365" class="edge"><title>GO:0004871&#45;&gt;GO:0005057</title>
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<polygon style="fill:gray;stroke:gray;" points="270.781,-964.779 280,-970 276.049,-960.169 270.781,-964.779"/>
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<!-- GO:0004872 -->
<g id="node181" class="node"><title>GO:0004872</title>
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<polygon style="fill:none;stroke:black;" points="272,-880 272,-896 346,-896 346,-880 272,-880"/>
<text text-anchor="middle" x="309" y="-885.667" style="font-family:Arial;font-size:10px;">receptor activity</text>
</g>
<!-- GO:0004871&#45;&gt;GO:0004872 -->
<g id="edge379" class="edge"><title>GO:0004871&#45;&gt;GO:0004872</title>
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</g>
<!-- GO:0060089&#45;&gt;GO:0004871 -->
<g id="edge367" class="edge"><title>GO:0060089&#45;&gt;GO:0004871</title>
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<!-- GO:0019199&#45;&gt;GO:0004675 -->
<g id="edge371" class="edge"><title>GO:0019199&#45;&gt;GO:0004675</title>
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<polygon style="fill:gray;stroke:gray;" points="325.774,-641.427 332,-650 332.479,-639.416 325.774,-641.427"/>
</g>
<!-- GO:0004888 -->
<g id="node180" class="node"><title>GO:0004888</title>
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<polygon style="fill:none;stroke:black;" points="291,-764 291,-794 365,-794 365,-764 291,-764"/>
<text text-anchor="middle" x="328" y="-783.667" style="font-family:Arial;font-size:10px;">transmembrane</text>
<text text-anchor="middle" x="328" y="-771.667" style="font-family:Arial;font-size:10px;">receptor activity</text>
</g>
<!-- GO:0004888&#45;&gt;GO:0019199 -->
<g id="edge375" class="edge"><title>GO:0004888&#45;&gt;GO:0019199</title>
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<polygon style="fill:gray;stroke:gray;" points="326.512,-753.701 329,-764 333.478,-754.398 326.512,-753.701"/>
</g>
<!-- GO:0004872&#45;&gt;GO:0004888 -->
<g id="edge377" class="edge"><title>GO:0004872&#45;&gt;GO:0004888</title>
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<polygon style="fill:gray;stroke:gray;" points="308.529,-869.508 310,-880 315.393,-870.881 308.529,-869.508"/>
</g>
<!-- GO:0044459&#45;&gt;GO:0016324 -->
<g id="edge381" class="edge"><title>GO:0044459&#45;&gt;GO:0016324</title>
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<polygon style="fill:gray;stroke:gray;" points="1560.9,-755.2 1555,-764 1565.1,-760.8 1560.9,-755.2"/>
</g>
<!-- GO:0044459&#45;&gt;GO:0016323 -->
<g id="edge479" class="edge"><title>GO:0044459&#45;&gt;GO:0016323</title>
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<polygon style="fill:gray;stroke:gray;" points="1528.5,-754 1532,-764 1535.5,-754 1528.5,-754"/>
</g>
<!-- GO:0044459&#45;&gt;GO:0070022 -->
<g id="edge987" class="edge"><title>GO:0044459&#45;&gt;GO:0070022</title>
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<polygon style="fill:gray;stroke:gray;" points="1557.22,-754.781 1552,-764 1561.83,-760.049 1557.22,-754.781"/>
</g>
<!-- GO:0044459&#45;&gt;GO:0048179 -->
<g id="edge1235" class="edge"><title>GO:0044459&#45;&gt;GO:0048179</title>
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<polygon style="fill:gray;stroke:gray;" points="1503.45,-759.404 1513,-764 1508.4,-754.454 1503.45,-759.404"/>
</g>
<!-- GO:0031226 -->
<g id="node310" class="node"><title>GO:0031226</title>
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<polygon style="fill:none;stroke:black;" points="1332,-656 1332,-686 1418,-686 1418,-656 1332,-656"/>
<text text-anchor="middle" x="1375" y="-675.667" style="font-family:Arial;font-size:10px;">intrinsic to</text>
<text text-anchor="middle" x="1375" y="-663.667" style="font-family:Arial;font-size:10px;">plasma membrane</text>
</g>
<!-- GO:0044459&#45;&gt;GO:0031226 -->
<g id="edge1001" class="edge"><title>GO:0044459&#45;&gt;GO:0031226</title>
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<polygon style="fill:gray;stroke:gray;" points="1499.9,-760.8 1510,-764 1504.1,-755.2 1499.9,-760.8"/>
</g>
<!-- GO:0044425 -->
<g id="node183" class="node"><title>GO:0044425</title>
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<polygon style="fill:none;stroke:black;" points="1383,-880 1383,-896 1455,-896 1455,-880 1383,-880"/>
<text text-anchor="middle" x="1419" y="-885.667" style="font-family:Arial;font-size:10px;">membrane part</text>
</g>
<!-- GO:0044425&#45;&gt;GO:0044459 -->
<g id="edge383" class="edge"><title>GO:0044425&#45;&gt;GO:0044459</title>
<path style="fill:none;stroke:gray;" d="M1434,-873C1456,-852 1495,-814 1516,-794"/>
<polygon style="fill:gray;stroke:gray;" points="1431.6,-870.454 1427,-880 1436.55,-875.404 1431.6,-870.454"/>
</g>
<!-- GO:0031224 -->
<g id="node309" class="node"><title>GO:0031224</title>
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<polygon style="fill:none;stroke:black;" points="1349,-764 1349,-794 1401,-794 1401,-764 1349,-764"/>
<text text-anchor="middle" x="1375" y="-783.667" style="font-family:Arial;font-size:10px;">intrinsic to</text>
<text text-anchor="middle" x="1375" y="-771.667" style="font-family:Arial;font-size:10px;">membrane</text>
</g>
<!-- GO:0044425&#45;&gt;GO:0031224 -->
<g id="edge995" class="edge"><title>GO:0044425&#45;&gt;GO:0031224</title>
<path style="fill:none;stroke:gray;" d="M1412,-871C1403,-849 1389,-814 1381,-794"/>
<polygon style="fill:gray;stroke:gray;" points="1408.74,-872.283 1416,-880 1415.14,-869.44 1408.74,-872.283"/>
</g>
<!-- GO:0044464&#45;&gt;GO:0009986 -->
<g id="edge1247" class="edge"><title>GO:0044464&#45;&gt;GO:0009986</title>
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<polygon style="fill:gray;stroke:gray;" points="1577.5,-1056 1581,-1066 1584.5,-1056 1577.5,-1056"/>
</g>
<!-- GO:0044464&#45;&gt;GO:0044425 -->
<g id="edge385" class="edge"><title>GO:0044464&#45;&gt;GO:0044425</title>
<path style="fill:none;stroke:gray;" d="M1551,-1071C1518,-1066 1466,-1053 1438,-1020 1408,-982 1414,-919 1418,-896"/>
<polygon style="fill:gray;stroke:gray;" points="1550.7,-1074.49 1561,-1072 1551.4,-1067.52 1550.7,-1074.49"/>
</g>
<!-- GO:0016020 -->
<g id="node186" class="node"><title>GO:0016020</title>
<polygon style="fill:white;stroke:white;" points="1455,-977 1455,-993 1507,-993 1507,-977 1455,-977"/>
<polygon style="fill:none;stroke:black;" points="1455,-977 1455,-993 1507,-993 1507,-977 1455,-977"/>
<text text-anchor="middle" x="1481" y="-982.667" style="font-family:Arial;font-size:10px;">membrane</text>
</g>
<!-- GO:0044464&#45;&gt;GO:0016020 -->
<g id="edge395" class="edge"><title>GO:0044464&#45;&gt;GO:0016020</title>
<path style="fill:none;stroke:gray;" d="M1564,-1059C1543,-1040 1507,-1008 1490,-993"/>
<polygon style="fill:gray;stroke:gray;" points="1562.17,-1062.05 1572,-1066 1566.78,-1056.78 1562.17,-1062.05"/>
</g>
<!-- GO:0045177 -->
<g id="node187" class="node"><title>GO:0045177</title>
<polygon style="fill:white;stroke:white;" points="1655,-970 1655,-1000 1707,-1000 1707,-970 1655,-970"/>
<polygon style="fill:none;stroke:black;" points="1655,-970 1655,-1000 1707,-1000 1707,-970 1655,-970"/>
<text text-anchor="middle" x="1681" y="-989.667" style="font-family:Arial;font-size:10px;">apical part</text>
<text text-anchor="middle" x="1681" y="-977.667" style="font-family:Arial;font-size:10px;">of cell</text>
</g>
<!-- GO:0044464&#45;&gt;GO:0045177 -->
<g id="edge403" class="edge"><title>GO:0044464&#45;&gt;GO:0045177</title>
<path style="fill:none;stroke:gray;" d="M1598,-1059C1616,-1043 1646,-1016 1664,-1000"/>
<polygon style="fill:gray;stroke:gray;" points="1595.22,-1056.78 1590,-1066 1599.83,-1062.05 1595.22,-1056.78"/>
</g>
<!-- GO:0005623&#45;&gt;GO:0044464 -->
<g id="edge389" class="edge"><title>GO:0005623&#45;&gt;GO:0044464</title>
<path style="fill:none;stroke:blue;" d="M1581,-1129C1581,-1114 1581,-1094 1581,-1082"/>
<polygon style="fill:blue;stroke:blue;" points="1577.5,-1129 1581,-1139 1584.5,-1129 1577.5,-1129"/>
</g>
<!-- GO:0016020&#45;&gt;GO:0005886 -->
<g id="edge399" class="edge"><title>GO:0016020&#45;&gt;GO:0005886</title>
<path style="fill:none;stroke:gray;" d="M1491,-968C1502,-951 1519,-926 1527,-912"/>
<polygon style="fill:gray;stroke:gray;" points="1487.8,-966.559 1486,-977 1493.92,-969.958 1487.8,-966.559"/>
</g>
<!-- GO:0016020&#45;&gt;GO:0044425 -->
<g id="edge393" class="edge"><title>GO:0016020&#45;&gt;GO:0044425</title>
<path style="fill:none;stroke:blue;" d="M1471,-969C1457,-947 1434,-912 1424,-896"/>
<polygon style="fill:blue;stroke:blue;" points="1467.73,-970.375 1476,-977 1473.67,-966.665 1467.73,-970.375"/>
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<!-- GO:0045177&#45;&gt;GO:0016324 -->
<g id="edge401" class="edge"><title>GO:0045177&#45;&gt;GO:0016324</title>
<path style="fill:none;stroke:blue;" d="M1681,-960C1681,-900 1681,-748 1681,-692"/>
<polygon style="fill:blue;stroke:blue;" points="1677.5,-960 1681,-970 1684.5,-960 1677.5,-960"/>
</g>
<!-- GO:0019899&#45;&gt;GO:0031625 -->
<g id="edge405" class="edge"><title>GO:0019899&#45;&gt;GO:0031625</title>
<path style="fill:none;stroke:gray;" d="M877,-967C877,-950 877,-926 878,-909"/>
<polygon style="fill:gray;stroke:gray;" points="873.5,-967 877,-977 880.5,-967 873.5,-967"/>
</g>
<!-- GO:0005488&#45;&gt;GO:0005515 -->
<g id="edge409" class="edge"><title>GO:0005488&#45;&gt;GO:0005515</title>
<path style="fill:none;stroke:gray;" d="M768,-1129C768,-1121 768,-1112 768,-1106"/>
<polygon style="fill:gray;stroke:gray;" points="764.5,-1129 768,-1139 771.5,-1129 764.5,-1129"/>
</g>
<!-- GO:0000166 -->
<g id="node314" class="node"><title>GO:0000166</title>
<polygon style="fill:white;stroke:white;" points="1152,-1066 1152,-1082 1236,-1082 1236,-1066 1152,-1066"/>
<polygon style="fill:none;stroke:black;" points="1152,-1066 1152,-1082 1236,-1082 1236,-1066 1152,-1066"/>
<text text-anchor="middle" x="1194" y="-1071.67" style="font-family:Arial;font-size:10px;">nucleotide binding</text>
</g>
<!-- GO:0005488&#45;&gt;GO:0000166 -->
<g id="edge1011" class="edge"><title>GO:0005488&#45;&gt;GO:0000166</title>
<path style="fill:none;stroke:gray;" d="M796,-1142C869,-1130 1065,-1096 1152,-1081"/>
<polygon style="fill:gray;stroke:gray;" points="795.119,-1138.61 786,-1144 796.492,-1145.47 795.119,-1138.61"/>
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<!-- GO:0032147 -->
<g id="node190" class="node"><title>GO:0032147</title>
<polygon style="fill:white;stroke:white;" points="6951,-442 6951,-484 7017,-484 7017,-442 6951,-442"/>
<polygon style="fill:none;stroke:black;" points="6951,-442 6951,-484 7017,-484 7017,-442 6951,-442"/>
<text text-anchor="middle" x="6984" y="-473.667" style="font-family:Arial;font-size:10px;">activation of</text>
<text text-anchor="middle" x="6984" y="-461.667" style="font-family:Arial;font-size:10px;">protein kinase</text>
<text text-anchor="middle" x="6984" y="-449.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0032147&#45;&gt;GO:0000186 -->
<g id="edge415" class="edge"><title>GO:0032147&#45;&gt;GO:0000186</title>
<path style="fill:none;stroke:gray;" d="M6984,-432C6984,-413 6984,-389 6984,-374"/>
<polygon style="fill:gray;stroke:gray;" points="6980.5,-432 6984,-442 6987.5,-432 6980.5,-432"/>
</g>
<!-- GO:0045860 -->
<g id="node191" class="node"><title>GO:0045860</title>
<polygon style="fill:white;stroke:white;" points="6942,-552 6942,-594 7026,-594 7026,-552 6942,-552"/>
<polygon style="fill:none;stroke:black;" points="6942,-552 6942,-594 7026,-594 7026,-552 6942,-552"/>
<text text-anchor="middle" x="6984" y="-583.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6984" y="-571.667" style="font-family:Arial;font-size:10px;">of protein kinase</text>
<text text-anchor="middle" x="6984" y="-559.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0045860&#45;&gt;GO:0032147 -->
<g id="edge417" class="edge"><title>GO:0045860&#45;&gt;GO:0032147</title>
<path style="fill:none;stroke:gray;" d="M6984,-542C6984,-524 6984,-501 6984,-484"/>
<polygon style="fill:gray;stroke:gray;" points="6980.5,-542 6984,-552 6987.5,-542 6980.5,-542"/>
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<!-- GO:0033674 -->
<g id="node192" class="node"><title>GO:0033674</title>
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<polygon style="fill:none;stroke:black;" points="6887,-656 6887,-686 6971,-686 6971,-656 6887,-656"/>
<text text-anchor="middle" x="6929" y="-675.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6929" y="-663.667" style="font-family:Arial;font-size:10px;">of kinase activity</text>
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<!-- GO:0033674&#45;&gt;GO:0045860 -->
<g id="edge419" class="edge"><title>GO:0033674&#45;&gt;GO:0045860</title>
<path style="fill:none;stroke:gray;" d="M6943,-647C6952,-631 6964,-610 6972,-594"/>
<polygon style="fill:gray;stroke:gray;" points="6939.8,-645.559 6938,-656 6945.92,-648.958 6939.8,-645.559"/>
</g>
<!-- GO:0043549 -->
<g id="node193" class="node"><title>GO:0043549</title>
<polygon style="fill:white;stroke:white;" points="7004,-764 7004,-794 7072,-794 7072,-764 7004,-764"/>
<polygon style="fill:none;stroke:black;" points="7004,-764 7004,-794 7072,-794 7072,-764 7004,-764"/>
<text text-anchor="middle" x="7038" y="-783.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="7038" y="-771.667" style="font-family:Arial;font-size:10px;">kinase activity</text>
</g>
<!-- GO:0043549&#45;&gt;GO:0033674 -->
<g id="edge421" class="edge"><title>GO:0043549&#45;&gt;GO:0033674</title>
<path style="fill:none;stroke:gray;" d="M7016,-757C6994,-736 6963,-705 6944,-686"/>
<polygon style="fill:gray;stroke:gray;" points="7013.45,-759.404 7023,-764 7018.4,-754.454 7013.45,-759.404"/>
</g>
<!-- GO:0045859 -->
<g id="node199" class="node"><title>GO:0045859</title>
<polygon style="fill:white;stroke:white;" points="7005,-650 7005,-692 7071,-692 7071,-650 7005,-650"/>
<polygon style="fill:none;stroke:black;" points="7005,-650 7005,-692 7071,-692 7071,-650 7005,-650"/>
<text text-anchor="middle" x="7038" y="-681.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="7038" y="-669.667" style="font-family:Arial;font-size:10px;">protein kinase</text>
<text text-anchor="middle" x="7038" y="-657.667" style="font-family:Arial;font-size:10px;">activity</text>
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<!-- GO:0043549&#45;&gt;GO:0045859 -->
<g id="edge441" class="edge"><title>GO:0043549&#45;&gt;GO:0045859</title>
<path style="fill:none;stroke:gray;" d="M7038,-754C7038,-735 7038,-710 7038,-692"/>
<polygon style="fill:gray;stroke:gray;" points="7034.5,-754 7038,-764 7041.5,-754 7034.5,-754"/>
</g>
<!-- GO:0051338 -->
<g id="node194" class="node"><title>GO:0051338</title>
<polygon style="fill:white;stroke:white;" points="7013,-867 7013,-909 7071,-909 7071,-867 7013,-867"/>
<polygon style="fill:none;stroke:black;" points="7013,-867 7013,-909 7071,-909 7071,-867 7013,-867"/>
<text text-anchor="middle" x="7042" y="-898.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="7042" y="-886.667" style="font-family:Arial;font-size:10px;">transferase</text>
<text text-anchor="middle" x="7042" y="-874.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0051338&#45;&gt;GO:0043549 -->
<g id="edge423" class="edge"><title>GO:0051338&#45;&gt;GO:0043549</title>
<path style="fill:none;stroke:gray;" d="M7041,-857C7040,-837 7039,-810 7039,-794"/>
<polygon style="fill:gray;stroke:gray;" points="7037.5,-857 7041,-867 7044.5,-857 7037.5,-857"/>
</g>
<!-- GO:0051347 -->
<g id="node197" class="node"><title>GO:0051347</title>
<polygon style="fill:white;stroke:white;" points="6886,-758 6886,-800 6970,-800 6970,-758 6886,-758"/>
<polygon style="fill:none;stroke:black;" points="6886,-758 6886,-800 6970,-800 6970,-758 6886,-758"/>
<text text-anchor="middle" x="6928" y="-789.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6928" y="-777.667" style="font-family:Arial;font-size:10px;">of transferase</text>
<text text-anchor="middle" x="6928" y="-765.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0051338&#45;&gt;GO:0051347 -->
<g id="edge437" class="edge"><title>GO:0051338&#45;&gt;GO:0051347</title>
<path style="fill:none;stroke:gray;" d="M7013,-860C6993,-841 6969,-817 6950,-800"/>
<polygon style="fill:gray;stroke:gray;" points="7010.45,-862.404 7020,-867 7015.4,-857.454 7010.45,-862.404"/>
</g>
<!-- GO:0050790 -->
<g id="node195" class="node"><title>GO:0050790</title>
<polygon style="fill:white;stroke:white;" points="6882,-970 6882,-1000 6958,-1000 6958,-970 6882,-970"/>
<polygon style="fill:none;stroke:black;" points="6882,-970 6882,-1000 6958,-1000 6958,-970 6882,-970"/>
<text text-anchor="middle" x="6920" y="-989.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="6920" y="-977.667" style="font-family:Arial;font-size:10px;">catalytic activity</text>
</g>
<!-- GO:0050790&#45;&gt;GO:0051338 -->
<g id="edge425" class="edge"><title>GO:0050790&#45;&gt;GO:0051338</title>
<path style="fill:none;stroke:gray;" d="M6953,-964C6966,-955 6982,-943 6996,-932 7004,-925 7013,-917 7021,-909"/>
<polygon style="fill:gray;stroke:gray;" points="6950.38,-961.541 6944,-970 6954.26,-967.365 6950.38,-961.541"/>
</g>
<!-- GO:0043085 -->
<g id="node198" class="node"><title>GO:0043085</title>
<polygon style="fill:white;stroke:white;" points="6895,-867 6895,-909 6979,-909 6979,-867 6895,-867"/>
<polygon style="fill:none;stroke:black;" points="6895,-867 6895,-909 6979,-909 6979,-867 6895,-867"/>
<text text-anchor="middle" x="6937" y="-898.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="6937" y="-886.667" style="font-family:Arial;font-size:10px;">of catalytic</text>
<text text-anchor="middle" x="6937" y="-874.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0050790&#45;&gt;GO:0043085 -->
<g id="edge435" class="edge"><title>GO:0050790&#45;&gt;GO:0043085</title>
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<g id="edge427" class="edge"><title>GO:0065009&#45;&gt;GO:0050790</title>
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<g id="edge431" class="edge"><title>GO:0051347&#45;&gt;GO:0033674</title>
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<!-- GO:0043085&#45;&gt;GO:0051347 -->
<g id="edge433" class="edge"><title>GO:0043085&#45;&gt;GO:0051347</title>
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<!-- GO:0045859&#45;&gt;GO:0045860 -->
<g id="edge439" class="edge"><title>GO:0045859&#45;&gt;GO:0045860</title>
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<!-- GO:0000165 -->
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<!-- GO:0000165&#45;&gt;GO:0000186 -->
<g id="edge443" class="edge"><title>GO:0000165&#45;&gt;GO:0000186</title>
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<!-- GO:0007243&#45;&gt;GO:0000165 -->
<g id="edge445" class="edge"><title>GO:0007243&#45;&gt;GO:0000165</title>
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<text text-anchor="middle" x="6297" y="-461.667" style="font-family:Arial;font-size:10px;">of protein kinase</text>
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<!-- GO:0007243&#45;&gt;GO:0010740 -->
<g id="edge569" class="edge"><title>GO:0007243&#45;&gt;GO:0010740</title>
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<!-- GO:0010627 -->
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<polygon style="fill:none;stroke:black;" points="6191,-552 6191,-594 6257,-594 6257,-552 6191,-552"/>
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<!-- GO:0007243&#45;&gt;GO:0010627 -->
<g id="edge567" class="edge"><title>GO:0007243&#45;&gt;GO:0010627</title>
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<polygon style="fill:black;stroke:black;" points="6176.8,-645.559 6175,-656 6182.92,-648.958 6176.8,-645.559"/>
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<text text-anchor="middle" x="6124" y="-571.667" style="font-family:Arial;font-size:10px;">B signaling</text>
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<!-- GO:0007243&#45;&gt;GO:0043491 -->
<g id="edge577" class="edge"><title>GO:0007243&#45;&gt;GO:0043491</title>
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<!-- GO:0007242&#45;&gt;GO:0007243 -->
<g id="edge447" class="edge"><title>GO:0007242&#45;&gt;GO:0007243</title>
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<!-- GO:0051726&#45;&gt;GO:0007346 -->
<g id="edge451" class="edge"><title>GO:0051726&#45;&gt;GO:0007346</title>
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<!-- GO:0007049&#45;&gt;GO:0051726 -->
<g id="edge455" class="edge"><title>GO:0007049&#45;&gt;GO:0051726</title>
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<!-- GO:0000278 -->
<g id="node205" class="node"><title>GO:0000278</title>
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<text text-anchor="middle" x="6834" y="-880.667" style="font-family:Arial;font-size:10px;">cycle</text>
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<!-- GO:0007049&#45;&gt;GO:0000278 -->
<g id="edge461" class="edge"><title>GO:0007049&#45;&gt;GO:0000278</title>
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<!-- GO:0000278&#45;&gt;GO:0007346 -->
<g id="edge459" class="edge"><title>GO:0000278&#45;&gt;GO:0007346</title>
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<!-- GO:0002119 -->
<g id="node206" class="node"><title>GO:0002119</title>
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<text text-anchor="middle" x="4535" y="-771.667" style="font-family:Arial;font-size:10px;">development</text>
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<!-- GO:0002119&#45;&gt;GO:0040024 -->
<g id="edge463" class="edge"><title>GO:0002119&#45;&gt;GO:0040024</title>
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<polygon style="fill:gray;stroke:gray;" points="4523.77,-755.427 4530,-764 4530.48,-753.416 4523.77,-755.427"/>
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<!-- GO:0002164&#45;&gt;GO:0002119 -->
<g id="edge465" class="edge"><title>GO:0002164&#45;&gt;GO:0002119</title>
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<!-- GO:0030198&#45;&gt;GO:0030199 -->
<g id="edge469" class="edge"><title>GO:0030198&#45;&gt;GO:0030199</title>
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<!-- GO:0043062&#45;&gt;GO:0030198 -->
<g id="edge471" class="edge"><title>GO:0043062&#45;&gt;GO:0030198</title>
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<!-- GO:0016043&#45;&gt;GO:0043062 -->
<g id="edge473" class="edge"><title>GO:0016043&#45;&gt;GO:0043062</title>
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<g id="edge711" class="edge"><title>GO:0016043&#45;&gt;GO:0051128</title>
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<!-- GO:0016043&#45;&gt;GO:0032989 -->
<g id="edge719" class="edge"><title>GO:0016043&#45;&gt;GO:0032989</title>
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<!-- GO:0016043&#45;&gt;GO:0051130 -->
<g id="edge735" class="edge"><title>GO:0016043&#45;&gt;GO:0051130</title>
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<!-- GO:0006928&#45;&gt;GO:0048870 -->
<g id="edge481" class="edge"><title>GO:0006928&#45;&gt;GO:0048870</title>
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<!-- GO:0006928&#45;&gt;GO:0051272 -->
<g id="edge977" class="edge"><title>GO:0006928&#45;&gt;GO:0051272</title>
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<!-- GO:0006928&#45;&gt;GO:0007411 -->
<g id="edge1067" class="edge"><title>GO:0006928&#45;&gt;GO:0007411</title>
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<g id="edge975" class="edge"><title>GO:0006928&#45;&gt;GO:0051270</title>
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<text text-anchor="middle" x="7749" y="-1066.67" style="font-family:Arial;font-size:10px;">of cell</text>
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<!-- GO:0051674&#45;&gt;GO:0006928 -->
<g id="edge485" class="edge"><title>GO:0051674&#45;&gt;GO:0006928</title>
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<g id="edge487" class="edge"><title>GO:0051179&#45;&gt;GO:0051674</title>
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<!-- GO:0051179&#45;&gt;GO:0032879 -->
<g id="edge603" class="edge"><title>GO:0051179&#45;&gt;GO:0032879</title>
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<g id="edge611" class="edge"><title>GO:0051179&#45;&gt;GO:0051234</title>
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<!-- GO:0040011&#45;&gt;GO:0048870 -->
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<g id="edge497" class="edge"><title>GO:0030182&#45;&gt;GO:0048666</title>
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<!-- GO:0030182&#45;&gt;GO:0048663 -->
<g id="edge953" class="edge"><title>GO:0030182&#45;&gt;GO:0048663</title>
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<!-- GO:0017002&#45;&gt;GO:0016361 -->
<g id="edge507" class="edge"><title>GO:0017002&#45;&gt;GO:0016361</title>
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<g id="edge513" class="edge"><title>GO:0016477&#45;&gt;GO:0008354</title>
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<!-- GO:0007276 -->
<g id="node218" class="node"><title>GO:0007276</title>
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<!-- GO:0007276&#45;&gt;GO:0008354 -->
<g id="edge517" class="edge"><title>GO:0007276&#45;&gt;GO:0008354</title>
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<!-- GO:0022414&#45;&gt;GO:0007276 -->
<g id="edge519" class="edge"><title>GO:0022414&#45;&gt;GO:0007276</title>
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<!-- GO:0007565 -->
<g id="node302" class="node"><title>GO:0007565</title>
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<!-- GO:0022414&#45;&gt;GO:0007565 -->
<g id="edge961" class="edge"><title>GO:0022414&#45;&gt;GO:0007565</title>
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<!-- GO:0000003&#45;&gt;GO:0022414 -->
<g id="edge523" class="edge"><title>GO:0000003&#45;&gt;GO:0022414</title>
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<!-- GO:0000003&#45;&gt;GO:0019953 -->
<g id="edge529" class="edge"><title>GO:0000003&#45;&gt;GO:0019953</title>
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<g id="edge527" class="edge"><title>GO:0019953&#45;&gt;GO:0007276</title>
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<g id="edge533" class="edge"><title>GO:0031099&#45;&gt;GO:0031100</title>
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<g id="edge539" class="edge"><title>GO:0010740&#45;&gt;GO:0051897</title>
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<!-- GO:0009966&#45;&gt;GO:0009967 -->
<g id="edge543" class="edge"><title>GO:0009966&#45;&gt;GO:0009967</title>
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<g id="edge565" class="edge"><title>GO:0009966&#45;&gt;GO:0010627</title>
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<!-- GO:0010646&#45;&gt;GO:0009966 -->
<g id="edge545" class="edge"><title>GO:0010646&#45;&gt;GO:0009966</title>
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<!-- GO:0010646&#45;&gt;GO:0010647 -->
<g id="edge555" class="edge"><title>GO:0010646&#45;&gt;GO:0010647</title>
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<g id="node247" class="node"><title>GO:0046883</title>
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<polygon style="fill:none;stroke:black;" points="9697,-656 9697,-686 9783,-686 9783,-656 9697,-656"/>
<text text-anchor="middle" x="9740" y="-675.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="9740" y="-663.667" style="font-family:Arial;font-size:10px;">hormone secretion</text>
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<!-- GO:0010646&#45;&gt;GO:0046883 -->
<g id="edge645" class="edge"><title>GO:0010646&#45;&gt;GO:0046883</title>
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<!-- GO:0010647&#45;&gt;GO:0009967 -->
<g id="edge553" class="edge"><title>GO:0010647&#45;&gt;GO:0009967</title>
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<!-- GO:0010627&#45;&gt;GO:0010740 -->
<g id="edge563" class="edge"><title>GO:0010627&#45;&gt;GO:0010740</title>
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<polygon style="fill:gray;stroke:gray;" points="6241.2,-541.9 6238,-552 6246.8,-546.1 6241.2,-541.9"/>
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<g id="node229" class="node"><title>GO:0051896</title>
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<polygon style="fill:none;stroke:black;" points="6155,-436 6155,-490 6221,-490 6221,-436 6155,-436"/>
<text text-anchor="middle" x="6188" y="-479.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="6188" y="-467.667" style="font-family:Arial;font-size:10px;">protein kinase</text>
<text text-anchor="middle" x="6188" y="-455.667" style="font-family:Arial;font-size:10px;">B signaling</text>
<text text-anchor="middle" x="6188" y="-443.667" style="font-family:Arial;font-size:10px;">cascade</text>
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<!-- GO:0010627&#45;&gt;GO:0051896 -->
<g id="edge573" class="edge"><title>GO:0010627&#45;&gt;GO:0051896</title>
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<polygon style="fill:gray;stroke:gray;" points="6210.77,-543.427 6217,-552 6217.48,-541.416 6210.77,-543.427"/>
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<!-- GO:0051896&#45;&gt;GO:0051897 -->
<g id="edge571" class="edge"><title>GO:0051896&#45;&gt;GO:0051897</title>
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<!-- GO:0043491&#45;&gt;GO:0051897 -->
<g id="edge579" class="edge"><title>GO:0043491&#45;&gt;GO:0051897</title>
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<!-- GO:0043491&#45;&gt;GO:0051896 -->
<g id="edge575" class="edge"><title>GO:0043491&#45;&gt;GO:0051896</title>
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<polygon style="fill:black;stroke:black;" points="6137.8,-541.559 6136,-552 6143.92,-544.958 6137.8,-541.559"/>
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<!-- GO:0034694&#45;&gt;GO:0034695 -->
<g id="edge581" class="edge"><title>GO:0034694&#45;&gt;GO:0034695</title>
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</g>
<!-- GO:0033993 -->
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<polygon style="fill:none;stroke:black;" points="10172,-873 10172,-903 10230,-903 10230,-873 10172,-873"/>
<text text-anchor="middle" x="10201" y="-892.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="10201" y="-880.667" style="font-family:Arial;font-size:10px;">lipid</text>
</g>
<!-- GO:0033993&#45;&gt;GO:0034694 -->
<g id="edge585" class="edge"><title>GO:0033993&#45;&gt;GO:0034694</title>
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<!-- GO:0010033&#45;&gt;GO:0014070 -->
<g id="edge943" class="edge"><title>GO:0010033&#45;&gt;GO:0014070</title>
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<!-- GO:0010033&#45;&gt;GO:0033993 -->
<g id="edge587" class="edge"><title>GO:0010033&#45;&gt;GO:0033993</title>
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<polygon style="fill:gray;stroke:gray;" points="10272.5,-965.404 10282,-970 10277.4,-960.454 10272.5,-965.404"/>
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<!-- GO:0009743 -->
<g id="node344" class="node"><title>GO:0009743</title>
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<polygon style="fill:none;stroke:black;" points="10364,-867 10364,-909 10426,-909 10426,-867 10364,-867"/>
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<text text-anchor="middle" x="10395" y="-886.667" style="font-family:Arial;font-size:10px;">carbohydrate</text>
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<!-- GO:0010033&#45;&gt;GO:0009743 -->
<g id="edge1165" class="edge"><title>GO:0010033&#45;&gt;GO:0009743</title>
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<polygon style="fill:gray;stroke:gray;" points="10317.2,-960.781 10312,-970 10321.8,-966.049 10317.2,-960.781"/>
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<!-- GO:0002792 -->
<g id="node234" class="node"><title>GO:0002792</title>
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<polygon style="fill:none;stroke:black;" points="10044,-558 10044,-588 10134,-588 10134,-558 10044,-558"/>
<text text-anchor="middle" x="10089" y="-577.667" style="font-family:Arial;font-size:10px;">negative regulation</text>
<text text-anchor="middle" x="10089" y="-565.667" style="font-family:Arial;font-size:10px;">of peptide secretion</text>
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<!-- GO:0002792&#45;&gt;GO:0046676 -->
<g id="edge591" class="edge"><title>GO:0002792&#45;&gt;GO:0046676</title>
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<!-- GO:0002791 -->
<g id="node235" class="node"><title>GO:0002791</title>
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<text text-anchor="middle" x="10089" y="-675.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<g id="edge593" class="edge"><title>GO:0002791&#45;&gt;GO:0002792</title>
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<text text-anchor="middle" x="9860" y="-467.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0002791&#45;&gt;GO:0050796 -->
<g id="edge679" class="edge"><title>GO:0002791&#45;&gt;GO:0050796</title>
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<g id="node236" class="node"><title>GO:0051046</title>
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<!-- GO:0051046&#45;&gt;GO:0002791 -->
<g id="edge595" class="edge"><title>GO:0051046&#45;&gt;GO:0002791</title>
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<g id="node244" class="node"><title>GO:0051048</title>
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<!-- GO:0051046&#45;&gt;GO:0051048 -->
<g id="edge627" class="edge"><title>GO:0051046&#45;&gt;GO:0051048</title>
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<!-- GO:0051046&#45;&gt;GO:0046883 -->
<g id="edge647" class="edge"><title>GO:0051046&#45;&gt;GO:0046883</title>
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<!-- GO:0051049 -->
<g id="node237" class="node"><title>GO:0051049</title>
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<polygon style="fill:none;stroke:black;" points="9770,-873 9770,-903 9828,-903 9828,-873 9770,-873"/>
<text text-anchor="middle" x="9799" y="-892.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0051049&#45;&gt;GO:0051046 -->
<g id="edge597" class="edge"><title>GO:0051049&#45;&gt;GO:0051046</title>
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</g>
<!-- GO:0051049&#45;&gt;GO:0051051 -->
<g id="edge633" class="edge"><title>GO:0051049&#45;&gt;GO:0051051</title>
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<g id="edge599" class="edge"><title>GO:0032879&#45;&gt;GO:0051049</title>
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<g id="edge971" class="edge"><title>GO:0032879&#45;&gt;GO:0051270</title>
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<!-- GO:0006810&#45;&gt;GO:0051049 -->
<g id="edge605" class="edge"><title>GO:0006810&#45;&gt;GO:0051049</title>
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<!-- GO:0046903 -->
<g id="node241" class="node"><title>GO:0046903</title>
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<polygon style="fill:none;stroke:black;" points="9980,-880 9980,-896 10026,-896 10026,-880 9980,-880"/>
<text text-anchor="middle" x="10003" y="-885.667" style="font-family:Arial;font-size:10px;">secretion</text>
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<!-- GO:0006810&#45;&gt;GO:0046903 -->
<g id="edge615" class="edge"><title>GO:0006810&#45;&gt;GO:0046903</title>
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<g id="node243" class="node"><title>GO:0015833</title>
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<text text-anchor="middle" x="10099" y="-885.667" style="font-family:Arial;font-size:10px;">peptide transport</text>
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<!-- GO:0006810&#45;&gt;GO:0015833 -->
<g id="edge621" class="edge"><title>GO:0006810&#45;&gt;GO:0015833</title>
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<!-- GO:0006810&#45;&gt;GO:0051051 -->
<g id="edge635" class="edge"><title>GO:0006810&#45;&gt;GO:0051051</title>
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<!-- GO:0006810&#45;&gt;GO:0009914 -->
<g id="edge661" class="edge"><title>GO:0006810&#45;&gt;GO:0009914</title>
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<g id="edge607" class="edge"><title>GO:0051234&#45;&gt;GO:0006810</title>
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<!-- GO:0046903&#45;&gt;GO:0051046 -->
<g id="edge613" class="edge"><title>GO:0046903&#45;&gt;GO:0051046</title>
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<!-- GO:0046903&#45;&gt;GO:0002790 -->
<g id="edge623" class="edge"><title>GO:0046903&#45;&gt;GO:0002790</title>
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<!-- GO:0046903&#45;&gt;GO:0051048 -->
<g id="edge637" class="edge"><title>GO:0046903&#45;&gt;GO:0051048</title>
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<!-- GO:0046903&#45;&gt;GO:0046879 -->
<g id="edge669" class="edge"><title>GO:0046903&#45;&gt;GO:0046879</title>
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<g id="edge639" class="edge"><title>GO:0002790&#45;&gt;GO:0002792</title>
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<g id="edge617" class="edge"><title>GO:0002790&#45;&gt;GO:0002791</title>
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<!-- GO:0002790&#45;&gt;GO:0030072 -->
<g id="edge687" class="edge"><title>GO:0002790&#45;&gt;GO:0030072</title>
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<g id="edge619" class="edge"><title>GO:0015833&#45;&gt;GO:0002790</title>
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<!-- GO:0051048&#45;&gt;GO:0002792 -->
<g id="edge625" class="edge"><title>GO:0051048&#45;&gt;GO:0002792</title>
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<!-- GO:0051048&#45;&gt;GO:0046888 -->
<g id="edge673" class="edge"><title>GO:0051048&#45;&gt;GO:0046888</title>
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<!-- GO:0051051&#45;&gt;GO:0051048 -->
<g id="edge629" class="edge"><title>GO:0051051&#45;&gt;GO:0051048</title>
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<!-- GO:0046888&#45;&gt;GO:0046676 -->
<g id="edge641" class="edge"><title>GO:0046888&#45;&gt;GO:0046676</title>
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<!-- GO:0046883&#45;&gt;GO:0046888 -->
<g id="edge643" class="edge"><title>GO:0046883&#45;&gt;GO:0046888</title>
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<!-- GO:0046883&#45;&gt;GO:0050796 -->
<g id="edge681" class="edge"><title>GO:0046883&#45;&gt;GO:0050796</title>
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<!-- GO:0046879&#45;&gt;GO:0046888 -->
<g id="edge675" class="edge"><title>GO:0046879&#45;&gt;GO:0046888</title>
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<!-- GO:0046879&#45;&gt;GO:0046883 -->
<g id="edge649" class="edge"><title>GO:0046879&#45;&gt;GO:0046883</title>
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<!-- GO:0046879&#45;&gt;GO:0030072 -->
<g id="edge689" class="edge"><title>GO:0046879&#45;&gt;GO:0030072</title>
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<!-- GO:0003001&#45;&gt;GO:0046879 -->
<g id="edge651" class="edge"><title>GO:0003001&#45;&gt;GO:0046879</title>
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<!-- GO:0007267&#45;&gt;GO:0003001 -->
<g id="edge655" class="edge"><title>GO:0007267&#45;&gt;GO:0003001</title>
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<!-- GO:0009914&#45;&gt;GO:0046879 -->
<g id="edge659" class="edge"><title>GO:0009914&#45;&gt;GO:0046879</title>
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<!-- GO:0010817 -->
<g id="node252" class="node"><title>GO:0010817</title>
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<polygon style="fill:none;stroke:black;" points="9189,-970 9189,-1000 9259,-1000 9259,-970 9189,-970"/>
<text text-anchor="middle" x="9224" y="-989.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<!-- GO:0010817&#45;&gt;GO:0009914 -->
<g id="edge663" class="edge"><title>GO:0010817&#45;&gt;GO:0009914</title>
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<!-- GO:0065008&#45;&gt;GO:0010817 -->
<g id="edge665" class="edge"><title>GO:0065008&#45;&gt;GO:0010817</title>
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<!-- GO:0008361 -->
<g id="node335" class="node"><title>GO:0008361</title>
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<text text-anchor="middle" x="7463" y="-989.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="7463" y="-977.667" style="font-family:Arial;font-size:10px;">cell size</text>
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<!-- GO:0065008&#45;&gt;GO:0008361 -->
<g id="edge1117" class="edge"><title>GO:0065008&#45;&gt;GO:0008361</title>
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<!-- GO:0050796&#45;&gt;GO:0046676 -->
<g id="edge677" class="edge"><title>GO:0050796&#45;&gt;GO:0046676</title>
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<g id="node255" class="node"><title>GO:0030073</title>
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<!-- GO:0030073&#45;&gt;GO:0046676 -->
<g id="edge691" class="edge"><title>GO:0030073&#45;&gt;GO:0046676</title>
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<!-- GO:0030073&#45;&gt;GO:0050796 -->
<g id="edge683" class="edge"><title>GO:0030073&#45;&gt;GO:0050796</title>
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<!-- GO:0030072&#45;&gt;GO:0030073 -->
<g id="edge685" class="edge"><title>GO:0030072&#45;&gt;GO:0030073</title>
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<g id="edge695" class="edge"><title>GO:0031346&#45;&gt;GO:0051491</title>
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<g id="node258" class="node"><title>GO:0031344</title>
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<polygon style="fill:none;stroke:black;" points="2973,-552 2973,-594 3039,-594 3039,-552 2973,-552"/>
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<text text-anchor="middle" x="3006" y="-571.667" style="font-family:Arial;font-size:10px;">cell projection</text>
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<!-- GO:0031344&#45;&gt;GO:0031346 -->
<g id="edge697" class="edge"><title>GO:0031344&#45;&gt;GO:0031346</title>
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<!-- GO:0051489 -->
<g id="node266" class="node"><title>GO:0051489</title>
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<text text-anchor="middle" x="2990" y="-229.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<g id="edge741" class="edge"><title>GO:0031344&#45;&gt;GO:0051489</title>
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<g id="node259" class="node"><title>GO:0022604</title>
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<text text-anchor="middle" x="2846" y="-675.667" style="font-family:Arial;font-size:10px;">regulation of</text>
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<g id="edge699" class="edge"><title>GO:0022604&#45;&gt;GO:0031344</title>
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<!-- GO:0022603&#45;&gt;GO:0022604 -->
<g id="edge701" class="edge"><title>GO:0022603&#45;&gt;GO:0022604</title>
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<g id="edge707" class="edge"><title>GO:0051128&#45;&gt;GO:0022604</title>
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<g id="edge733" class="edge"><title>GO:0051128&#45;&gt;GO:0051130</title>
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<g id="edge713" class="edge"><title>GO:0000902&#45;&gt;GO:0022604</title>
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<text text-anchor="middle" x="3074" y="-675.667" style="font-family:Arial;font-size:10px;">cell projection</text>
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<!-- GO:0000902&#45;&gt;GO:0030030 -->
<g id="edge725" class="edge"><title>GO:0000902&#45;&gt;GO:0030030</title>
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<g id="node327" class="node"><title>GO:0048858</title>
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<polygon style="fill:none;stroke:black;" points="3336,-558 3336,-588 3408,-588 3408,-558 3336,-558"/>
<text text-anchor="middle" x="3372" y="-577.667" style="font-family:Arial;font-size:10px;">cell projection</text>
<text text-anchor="middle" x="3372" y="-565.667" style="font-family:Arial;font-size:10px;">morphogenesis</text>
</g>
<!-- GO:0000902&#45;&gt;GO:0048858 -->
<g id="edge1081" class="edge"><title>GO:0000902&#45;&gt;GO:0048858</title>
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</g>
<!-- GO:0000902&#45;&gt;GO:0000904 -->
<g id="edge1093" class="edge"><title>GO:0000902&#45;&gt;GO:0000904</title>
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</g>
<!-- GO:0032989&#45;&gt;GO:0000902 -->
<g id="edge715" class="edge"><title>GO:0032989&#45;&gt;GO:0000902</title>
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</g>
<!-- GO:0032990 -->
<g id="node328" class="node"><title>GO:0032990</title>
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<polygon style="fill:none;stroke:black;" points="3317,-663 3317,-679 3427,-679 3427,-663 3317,-663"/>
<text text-anchor="middle" x="3372" y="-668.667" style="font-family:Arial;font-size:10px;">cell part morphogenesis</text>
</g>
<!-- GO:0032989&#45;&gt;GO:0032990 -->
<g id="edge1079" class="edge"><title>GO:0032989&#45;&gt;GO:0032990</title>
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<!-- GO:0030030&#45;&gt;GO:0031346 -->
<g id="edge737" class="edge"><title>GO:0030030&#45;&gt;GO:0031346</title>
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</g>
<!-- GO:0030030&#45;&gt;GO:0031344 -->
<g id="edge723" class="edge"><title>GO:0030030&#45;&gt;GO:0031344</title>
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<polygon style="fill:black;stroke:black;" points="3054.54,-649.621 3063,-656 3060.37,-645.738 3054.54,-649.621"/>
</g>
<!-- GO:0030031 -->
<g id="node269" class="node"><title>GO:0030031</title>
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<polygon style="fill:none;stroke:black;" points="2873,-558 2873,-588 2939,-588 2939,-558 2873,-558"/>
<text text-anchor="middle" x="2906" y="-577.667" style="font-family:Arial;font-size:10px;">cell projection</text>
<text text-anchor="middle" x="2906" y="-565.667" style="font-family:Arial;font-size:10px;">assembly</text>
</g>
<!-- GO:0030030&#45;&gt;GO:0030031 -->
<g id="edge749" class="edge"><title>GO:0030030&#45;&gt;GO:0030031</title>
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</g>
<!-- GO:0030030&#45;&gt;GO:0048858 -->
<g id="edge1075" class="edge"><title>GO:0030030&#45;&gt;GO:0048858</title>
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</g>
<!-- GO:0030030&#45;&gt;GO:0031175 -->
<g id="edge1085" class="edge"><title>GO:0030030&#45;&gt;GO:0031175</title>
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</g>
<!-- GO:0051130&#45;&gt;GO:0031346 -->
<g id="edge729" class="edge"><title>GO:0051130&#45;&gt;GO:0031346</title>
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<polygon style="fill:gray;stroke:gray;" points="3391.9,-749.2 3386,-758 3396.1,-754.8 3391.9,-749.2"/>
</g>
<!-- GO:0051489&#45;&gt;GO:0051491 -->
<g id="edge739" class="edge"><title>GO:0051489&#45;&gt;GO:0051491</title>
<path style="fill:none;stroke:gray;" d="M2990,-200C2990,-182 2990,-159 2990,-142"/>
<polygon style="fill:gray;stroke:gray;" points="2986.5,-200 2990,-210 2993.5,-200 2986.5,-200"/>
</g>
<!-- GO:0046847 -->
<g id="node267" class="node"><title>GO:0046847</title>
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<polygon style="fill:none;stroke:black;" points="2862,-335 2862,-351 2954,-351 2954,-335 2862,-335"/>
<text text-anchor="middle" x="2908" y="-340.667" style="font-family:Arial;font-size:10px;">filopodium formation</text>
</g>
<!-- GO:0046847&#45;&gt;GO:0051491 -->
<g id="edge751" class="edge"><title>GO:0046847&#45;&gt;GO:0051491</title>
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<!-- GO:0046847&#45;&gt;GO:0051489 -->
<g id="edge743" class="edge"><title>GO:0046847&#45;&gt;GO:0051489</title>
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<polygon style="fill:black;stroke:black;" points="2917.2,-324.9 2914,-335 2922.8,-329.1 2917.2,-324.9"/>
</g>
<!-- GO:0030035 -->
<g id="node268" class="node"><title>GO:0030035</title>
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<polygon style="fill:none;stroke:black;" points="2858,-455 2858,-471 2956,-471 2956,-455 2858,-455"/>
<text text-anchor="middle" x="2907" y="-460.667" style="font-family:Arial;font-size:10px;">microspike assembly</text>
</g>
<!-- GO:0030035&#45;&gt;GO:0046847 -->
<g id="edge745" class="edge"><title>GO:0030035&#45;&gt;GO:0046847</title>
<path style="fill:none;stroke:gray;" d="M2907,-445C2907,-418 2908,-370 2908,-351"/>
<polygon style="fill:gray;stroke:gray;" points="2903.5,-445 2907,-455 2910.5,-445 2903.5,-445"/>
</g>
<!-- GO:0030031&#45;&gt;GO:0030035 -->
<g id="edge747" class="edge"><title>GO:0030031&#45;&gt;GO:0030035</title>
<path style="fill:none;stroke:gray;" d="M2906,-548C2906,-523 2907,-487 2907,-471"/>
<polygon style="fill:gray;stroke:gray;" points="2902.5,-548 2906,-558 2909.5,-548 2902.5,-548"/>
</g>
<!-- GO:0006357 -->
<g id="node270" class="node"><title>GO:0006357</title>
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<polygon style="fill:none;stroke:black;" points="8852,-316 8852,-370 8954,-370 8954,-316 8852,-316"/>
<text text-anchor="middle" x="8903" y="-359.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="8903" y="-347.667" style="font-family:Arial;font-size:10px;">transcription</text>
<text text-anchor="middle" x="8903" y="-335.667" style="font-family:Arial;font-size:10px;">from RNA polymerase</text>
<text text-anchor="middle" x="8903" y="-323.667" style="font-family:Arial;font-size:10px;">II promoter</text>
</g>
<!-- GO:0006357&#45;&gt;GO:0045944 -->
<g id="edge753" class="edge"><title>GO:0006357&#45;&gt;GO:0045944</title>
<path style="fill:none;stroke:gray;" d="M8903,-306C8903,-291 8903,-273 8903,-258"/>
<polygon style="fill:gray;stroke:gray;" points="8899.5,-306 8903,-316 8906.5,-306 8899.5,-306"/>
</g>
<!-- GO:0006355&#45;&gt;GO:0006357 -->
<g id="edge755" class="edge"><title>GO:0006355&#45;&gt;GO:0006357</title>
<path style="fill:none;stroke:gray;" d="M8848,-433C8860,-414 8875,-389 8886,-370"/>
<polygon style="fill:gray;stroke:gray;" points="8844.8,-431.559 8843,-442 8850.92,-434.958 8844.8,-431.559"/>
</g>
<!-- GO:0045893 -->
<g id="node290" class="node"><title>GO:0045893</title>
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<polygon style="fill:none;stroke:black;" points="8734,-322 8734,-364 8818,-364 8818,-322 8734,-322"/>
<text text-anchor="middle" x="8776" y="-353.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8776" y="-341.667" style="font-family:Arial;font-size:10px;">of transcription,</text>
<text text-anchor="middle" x="8776" y="-329.667" style="font-family:Arial;font-size:10px;">DNA&#45;dependent</text>
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<!-- GO:0006355&#45;&gt;GO:0045893 -->
<g id="edge859" class="edge"><title>GO:0006355&#45;&gt;GO:0045893</title>
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<polygon style="fill:gray;stroke:gray;" points="8812.74,-434.283 8820,-442 8819.14,-431.44 8812.74,-434.283"/>
</g>
<!-- GO:0010556&#45;&gt;GO:0045449 -->
<g id="edge761" class="edge"><title>GO:0010556&#45;&gt;GO:0045449</title>
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<!-- GO:0010557 -->
<g id="node292" class="node"><title>GO:0010557</title>
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<text text-anchor="middle" x="8687" y="-687.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8687" y="-675.667" style="font-family:Arial;font-size:10px;">of macromolecule</text>
<text text-anchor="middle" x="8687" y="-663.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="8687" y="-651.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0010556&#45;&gt;GO:0010557 -->
<g id="edge879" class="edge"><title>GO:0010556&#45;&gt;GO:0010557</title>
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</g>
<!-- GO:0009889&#45;&gt;GO:0010556 -->
<g id="edge763" class="edge"><title>GO:0009889&#45;&gt;GO:0010556</title>
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<polygon style="fill:gray;stroke:gray;" points="8832.95,-857.169 8829,-867 8838.22,-861.779 8832.95,-857.169"/>
</g>
<!-- GO:0031326 -->
<g id="node279" class="node"><title>GO:0031326</title>
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<polygon style="fill:none;stroke:black;" points="9020,-758 9020,-800 9112,-800 9112,-758 9020,-758"/>
<text text-anchor="middle" x="9066" y="-789.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="9066" y="-777.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
<text text-anchor="middle" x="9066" y="-765.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009889&#45;&gt;GO:0031326 -->
<g id="edge797" class="edge"><title>GO:0009889&#45;&gt;GO:0031326</title>
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<polygon style="fill:gray;stroke:gray;" points="8845.04,-863.084 8838,-871 8848.44,-869.203 8845.04,-863.084"/>
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<!-- GO:0009891 -->
<g id="node293" class="node"><title>GO:0009891</title>
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<polygon style="fill:none;stroke:black;" points="8758,-758 8758,-800 8842,-800 8842,-758 8758,-758"/>
<text text-anchor="middle" x="8800" y="-789.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8800" y="-777.667" style="font-family:Arial;font-size:10px;">of biosynthetic</text>
<text text-anchor="middle" x="8800" y="-765.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009889&#45;&gt;GO:0009891 -->
<g id="edge867" class="edge"><title>GO:0009889&#45;&gt;GO:0009891</title>
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<polygon style="fill:gray;stroke:gray;" points="8802.52,-857.398 8807,-867 8809.49,-856.701 8802.52,-857.398"/>
</g>
<!-- GO:0009058&#45;&gt;GO:0009889 -->
<g id="edge767" class="edge"><title>GO:0009058&#45;&gt;GO:0009889</title>
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<polygon style="fill:black;stroke:black;" points="8803.5,-1049 8807,-1059 8810.5,-1049 8803.5,-1049"/>
</g>
<!-- GO:0009058&#45;&gt;GO:0009059 -->
<g id="edge775" class="edge"><title>GO:0009058&#45;&gt;GO:0009059</title>
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</g>
<!-- GO:0009058&#45;&gt;GO:0044249 -->
<g id="edge803" class="edge"><title>GO:0009058&#45;&gt;GO:0044249</title>
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<polygon style="fill:gray;stroke:gray;" points="8843.72,-1054.74 8836,-1062 8846.56,-1061.14 8843.72,-1054.74"/>
</g>
<!-- GO:0009058&#45;&gt;GO:0009891 -->
<g id="edge877" class="edge"><title>GO:0009058&#45;&gt;GO:0009891</title>
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</g>
<!-- GO:0009059&#45;&gt;GO:0010556 -->
<g id="edge773" class="edge"><title>GO:0009059&#45;&gt;GO:0010556</title>
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<polygon style="fill:black;stroke:black;" points="8880.53,-953.508 8882,-964 8887.39,-954.881 8880.53,-953.508"/>
</g>
<!-- GO:0009059&#45;&gt;GO:0034645 -->
<g id="edge815" class="edge"><title>GO:0009059&#45;&gt;GO:0034645</title>
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</g>
<!-- GO:0009059&#45;&gt;GO:0043284 -->
<g id="edge825" class="edge"><title>GO:0009059&#45;&gt;GO:0043284</title>
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</g>
<!-- GO:0009059&#45;&gt;GO:0010557 -->
<g id="edge889" class="edge"><title>GO:0009059&#45;&gt;GO:0010557</title>
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</g>
<!-- GO:0019219 -->
<g id="node276" class="node"><title>GO:0019219</title>
<polygon style="fill:white;stroke:white;" points="8456,-740 8456,-818 8542,-818 8542,-740 8456,-740"/>
<polygon style="fill:none;stroke:black;" points="8456,-740 8456,-818 8542,-818 8542,-740 8456,-740"/>
<text text-anchor="middle" x="8499" y="-807.667" style="font-family:Arial;font-size:10px;">regulation of</text>
<text text-anchor="middle" x="8499" y="-795.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
<text text-anchor="middle" x="8499" y="-783.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="8499" y="-771.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
<text text-anchor="middle" x="8499" y="-759.667" style="font-family:Arial;font-size:10px;">nucleic acid</text>
<text text-anchor="middle" x="8499" y="-747.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0019219&#45;&gt;GO:0045449 -->
<g id="edge779" class="edge"><title>GO:0019219&#45;&gt;GO:0045449</title>
<path style="fill:none;stroke:gray;" d="M8538,-732C8573,-689 8621,-631 8628,-628 8656,-611 8749,-598 8799,-592"/>
<polygon style="fill:gray;stroke:gray;" points="8534.95,-730.169 8531,-740 8540.22,-734.779 8534.95,-730.169"/>
</g>
<!-- GO:0019219&#45;&gt;GO:0051252 -->
<g id="edge833" class="edge"><title>GO:0019219&#45;&gt;GO:0051252</title>
<path style="fill:none;stroke:gray;" d="M8499,-730C8499,-717 8499,-703 8499,-692"/>
<polygon style="fill:gray;stroke:gray;" points="8495.5,-730 8499,-740 8502.5,-730 8495.5,-730"/>
</g>
<!-- GO:0045935 -->
<g id="node299" class="node"><title>GO:0045935</title>
<polygon style="fill:white;stroke:white;" points="8343,-632 8343,-710 8429,-710 8429,-632 8343,-632"/>
<polygon style="fill:none;stroke:black;" points="8343,-632 8343,-710 8429,-710 8429,-632 8343,-632"/>
<text text-anchor="middle" x="8386" y="-699.667" style="font-family:Arial;font-size:10px;">positive regulation</text>
<text text-anchor="middle" x="8386" y="-687.667" style="font-family:Arial;font-size:10px;">of nucleobase,</text>
<text text-anchor="middle" x="8386" y="-675.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="8386" y="-663.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
<text text-anchor="middle" x="8386" y="-651.667" style="font-family:Arial;font-size:10px;">nucleic acid</text>
<text text-anchor="middle" x="8386" y="-639.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0019219&#45;&gt;GO:0045935 -->
<g id="edge921" class="edge"><title>GO:0019219&#45;&gt;GO:0045935</title>
<path style="fill:none;stroke:gray;" d="M8451,-733C8443,-725 8435,-718 8427,-710"/>
<polygon style="fill:gray;stroke:gray;" points="8448.45,-735.404 8458,-740 8453.4,-730.454 8448.45,-735.404"/>
</g>
<!-- GO:0031323&#45;&gt;GO:0019219 -->
<g id="edge781" class="edge"><title>GO:0031323&#45;&gt;GO:0019219</title>
<path style="fill:none;stroke:gray;" d="M8445,-859C8453,-846 8463,-832 8472,-818"/>
<polygon style="fill:gray;stroke:gray;" points="8442.2,-856.9 8439,-867 8447.8,-861.1 8442.2,-856.9"/>
</g>
<!-- GO:0031323&#45;&gt;GO:0031326 -->
<g id="edge799" class="edge"><title>GO:0031323&#45;&gt;GO:0031326</title>
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<g id="edge845" class="edge"><title>GO:0006350&#45;&gt;GO:0006351</title>
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<!-- GO:0051252&#45;&gt;GO:0051254 -->
<g id="edge935" class="edge"><title>GO:0051252&#45;&gt;GO:0051254</title>
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<!-- GO:0016070&#45;&gt;GO:0051252 -->
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<g id="edge937" class="edge"><title>GO:0016070&#45;&gt;GO:0051254</title>
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<g id="edge1233" class="edge"><title>GO:0043235&#45;&gt;GO:0048179</title>
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<g id="edge983" class="edge"><title>GO:0032991&#45;&gt;GO:0043234</title>
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<!-- GO:0005887&#45;&gt;GO:0070022 -->
<g id="edge989" class="edge"><title>GO:0005887&#45;&gt;GO:0070022</title>
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<g id="edge1237" class="edge"><title>GO:0005887&#45;&gt;GO:0048179</title>
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<!-- GO:0016021&#45;&gt;GO:0005887 -->
<g id="edge991" class="edge"><title>GO:0016021&#45;&gt;GO:0005887</title>
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<!-- GO:0031224&#45;&gt;GO:0016021 -->
<g id="edge993" class="edge"><title>GO:0031224&#45;&gt;GO:0016021</title>
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<!-- GO:0031224&#45;&gt;GO:0031226 -->
<g id="edge999" class="edge"><title>GO:0031224&#45;&gt;GO:0031226</title>
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<polygon style="fill:gray;stroke:gray;" points="1371.5,-754 1375,-764 1378.5,-754 1371.5,-754"/>
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<!-- GO:0031226&#45;&gt;GO:0005887 -->
<g id="edge997" class="edge"><title>GO:0031226&#45;&gt;GO:0005887</title>
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<text text-anchor="middle" x="1180" y="-783.667" style="font-family:Arial;font-size:10px;">adenyl ribonucleotide</text>
<text text-anchor="middle" x="1180" y="-771.667" style="font-family:Arial;font-size:10px;">binding</text>
</g>
<!-- GO:0032559&#45;&gt;GO:0005524 -->
<g id="edge1003" class="edge"><title>GO:0032559&#45;&gt;GO:0005524</title>
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<text text-anchor="middle" x="1178" y="-880.667" style="font-family:Arial;font-size:10px;">binding</text>
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<!-- GO:0030554&#45;&gt;GO:0032559 -->
<g id="edge1005" class="edge"><title>GO:0030554&#45;&gt;GO:0032559</title>
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<text text-anchor="middle" x="1194" y="-977.667" style="font-family:Arial;font-size:10px;">binding</text>
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<!-- GO:0017076&#45;&gt;GO:0030554 -->
<g id="edge1007" class="edge"><title>GO:0017076&#45;&gt;GO:0030554</title>
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<!-- GO:0017076&#45;&gt;GO:0032555 -->
<g id="edge1015" class="edge"><title>GO:0017076&#45;&gt;GO:0032555</title>
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<!-- GO:0000166&#45;&gt;GO:0017076 -->
<g id="edge1009" class="edge"><title>GO:0000166&#45;&gt;GO:0017076</title>
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<!-- GO:0000166&#45;&gt;GO:0032553 -->
<g id="edge1019" class="edge"><title>GO:0000166&#45;&gt;GO:0032553</title>
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<g id="edge1017" class="edge"><title>GO:0032553&#45;&gt;GO:0032555</title>
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<!-- GO:0001832&#45;&gt;GO:0001834 -->
<g id="edge1023" class="edge"><title>GO:0001832&#45;&gt;GO:0001834</title>
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<g id="edge1025" class="edge"><title>GO:0048589&#45;&gt;GO:0001832</title>
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<g id="edge1029" class="edge"><title>GO:0040007&#45;&gt;GO:0048589</title>
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<g id="edge1105" class="edge"><title>GO:0040007&#45;&gt;GO:0040008</title>
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<g id="edge1125" class="edge"><title>GO:0040007&#45;&gt;GO:0045927</title>
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<g id="edge1153" class="edge"><title>GO:0040007&#45;&gt;GO:0035264</title>
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<g id="edge1033" class="edge"><title>GO:0001824&#45;&gt;GO:0001832</title>
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<g id="edge1041" class="edge"><title>GO:0045596&#45;&gt;GO:0045602</title>
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<g id="edge1043" class="edge"><title>GO:0045595&#45;&gt;GO:0045596</title>
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<!-- GO:0045595&#45;&gt;GO:0045601 -->
<g id="edge1059" class="edge"><title>GO:0045595&#45;&gt;GO:0045601</title>
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<g id="edge1057" class="edge"><title>GO:0045601&#45;&gt;GO:0045602</title>
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<g id="edge1065" class="edge"><title>GO:0045446&#45;&gt;GO:0045602</title>
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<g id="edge1061" class="edge"><title>GO:0045446&#45;&gt;GO:0045601</title>
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<g id="edge1069" class="edge"><title>GO:0007409&#45;&gt;GO:0007411</title>
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<g id="edge1071" class="edge"><title>GO:0048812&#45;&gt;GO:0007409</title>
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<g id="edge1073" class="edge"><title>GO:0048858&#45;&gt;GO:0048812</title>
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<g id="edge1131" class="edge"><title>GO:0008361&#45;&gt;GO:0045793</title>
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<g id="edge1155" class="edge"><title>GO:0048545&#45;&gt;GO:0043627</title>
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<g id="edge1159" class="edge"><title>GO:0009746&#45;&gt;GO:0009749</title>
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<g id="edge1161" class="edge"><title>GO:0034284&#45;&gt;GO:0009746</title>
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<g id="edge1163" class="edge"><title>GO:0009743&#45;&gt;GO:0034284</title>
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<g id="edge1193" class="edge"><title>GO:0048736&#45;&gt;GO:0048737</title>
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<!-- GO:0005160&#45;&gt;GO:0005114 -->
<g id="edge1251" class="edge"><title>GO:0005160&#45;&gt;GO:0005114</title>
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