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<g id="edge381" class="edge"><title>GO:0008150&#45;&gt;GO:0000003</title>
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<g id="edge77" class="edge"><title>GO:0008150&#45;&gt;GO:0050789</title>
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<g id="edge377" class="edge"><title>GO:0008150&#45;&gt;GO:0022414</title>
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<!-- GO:0015949 -->
<g id="node8" class="node"><title>GO:0015949</title>
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<text text-anchor="middle" x="2605" y="-666.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
<text text-anchor="middle" x="2605" y="-654.667" style="font-family:Arial;font-size:10px;">nucleoside and</text>
<text text-anchor="middle" x="2605" y="-642.667" style="font-family:Arial;font-size:10px;">nucleotide interconversion</text>
<text text-anchor="middle" x="2605" y="-630.667" style="font-family:Arial;font-size:10px;">Ecoli</text>
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<!-- GO:0006167 -->
<g id="node9" class="node"><title>GO:0006167</title>
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<polygon style="fill:none;stroke:black;" points="2859,-52 2859,-82 2943,-82 2943,-52 2859,-52"/>
<text text-anchor="middle" x="2901" y="-71.6667" style="font-family:Arial;font-size:10px;">AMP biosynthetic</text>
<text text-anchor="middle" x="2901" y="-59.6667" style="font-family:Arial;font-size:10px;">process</text>
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<text text-anchor="middle" x="2901" y="-41.6667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="2901" y="-25.6667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2901" y="-9.66667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0048046 -->
<g id="node10" class="node"><title>GO:0048046</title>
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<polygon style="fill:none;stroke:black;" points="1023,-985 1023,-1015 1065,-1015 1065,-985 1023,-985"/>
<text text-anchor="middle" x="1044" y="-1004.67" style="font-family:Arial;font-size:10px;">apoplast</text>
<text text-anchor="middle" x="1044" y="-992.667" style="font-family:Arial;font-size:10px;">Dicot</text>
</g>
<!-- GO:0009792 -->
<g id="node11" class="node"><title>GO:0009792</title>
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<text text-anchor="middle" x="1262" y="-803.667" style="font-family:Arial;font-size:10px;">embryonic development</text>
<text text-anchor="middle" x="1262" y="-791.667" style="font-family:Arial;font-size:10px;">ending in birth</text>
<text text-anchor="middle" x="1262" y="-779.667" style="font-family:Arial;font-size:10px;">or egg hatching</text>
<text text-anchor="middle" x="1262" y="-767.667" style="font-family:Arial;font-size:10px;">Worm</text>
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<!-- GO:0004019 -->
<g id="node12" class="node"><title>GO:0004019</title>
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<polygon style="fill:none;stroke:black;" points="565,-828 565,-858 647,-858 647,-828 565,-828"/>
<text text-anchor="middle" x="606" y="-847.667" style="font-family:Arial;font-size:10px;">adenylosuccinate</text>
<text text-anchor="middle" x="606" y="-835.667" style="font-family:Arial;font-size:10px;">synthase activity</text>
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<text text-anchor="middle" x="606" y="-817.667" style="font-family:Arial;font-size:10px;">Human</text>
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<text text-anchor="middle" x="606" y="-801.667" style="font-family:Arial;font-size:10px;">Dicty</text>
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<text text-anchor="middle" x="606" y="-785.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="606" y="-769.667" style="font-family:Arial;font-size:10px;">Yeast</text>
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<text text-anchor="middle" x="606" y="-753.667" style="font-family:Arial;font-size:10px;">Ecoli</text>
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<text text-anchor="middle" x="606" y="-737.667" style="font-family:Arial;font-size:10px;">Mouse</text>
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<text text-anchor="middle" x="606" y="-721.667" style="font-family:Arial;font-size:10px;">Fly: ISS_only</text>
</g>
<!-- GO:0009507 -->
<g id="node13" class="node"><title>GO:0009507</title>
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<polygon style="fill:none;stroke:black;" points="936,-346 936,-376 990,-376 990,-346 936,-346"/>
<text text-anchor="middle" x="963" y="-365.667" style="font-family:Arial;font-size:10px;">chloroplast</text>
<text text-anchor="middle" x="963" y="-353.667" style="font-family:Arial;font-size:10px;">Dicot</text>
</g>
<!-- GO:0044434 -->
<g id="node45" class="node"><title>GO:0044434</title>
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<polygon style="fill:none;stroke:black;" points="936,-212 936,-242 990,-242 990,-212 936,-212"/>
<text text-anchor="middle" x="963" y="-231.667" style="font-family:Arial;font-size:10px;">chloroplast</text>
<text text-anchor="middle" x="963" y="-219.667" style="font-family:Arial;font-size:10px;">part</text>
</g>
<!-- GO:0009507&#45;&gt;GO:0044434 -->
<g id="edge61" class="edge"><title>GO:0009507&#45;&gt;GO:0044434</title>
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<polygon style="fill:blue;stroke:blue;" points="959.5,-336 963,-346 966.5,-336 959.5,-336"/>
</g>
<!-- GO:0046686 -->
<g id="node14" class="node"><title>GO:0046686</title>
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<polygon style="fill:none;stroke:black;" points="2881,-651 2881,-681 2943,-681 2943,-651 2881,-651"/>
<text text-anchor="middle" x="2912" y="-670.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="2912" y="-658.667" style="font-family:Arial;font-size:10px;">cadmium ion</text>
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<text text-anchor="middle" x="2912" y="-640.667" style="font-family:Arial;font-size:10px;">Dicot</text>
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<polygon style="fill:none;stroke:black;" points="2881,-619 2881,-635 2943,-635 2943,-619 2881,-619"/>
<text text-anchor="middle" x="2912" y="-624.667" style="font-family:Arial;font-size:10px;">Pombe</text>
</g>
<!-- GO:0003688 -->
<g id="node15" class="node"><title>GO:0003688</title>
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<polygon style="fill:none;stroke:black;" points="452,-629 452,-671 526,-671 526,-629 452,-629"/>
<text text-anchor="middle" x="489" y="-660.667" style="font-family:Arial;font-size:10px;">DNA replication</text>
<text text-anchor="middle" x="489" y="-648.667" style="font-family:Arial;font-size:10px;">origin binding</text>
<text text-anchor="middle" x="489" y="-636.667" style="font-family:Arial;font-size:10px;">Yeast</text>
</g>
<!-- GO:0006163 -->
<g id="node16" class="node"><title>GO:0006163</title>
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<polygon style="fill:none;stroke:black;" points="2897,-459 2897,-501 2983,-501 2983,-459 2897,-459"/>
<text text-anchor="middle" x="2940" y="-490.667" style="font-family:Arial;font-size:10px;">purine nucleotide</text>
<text text-anchor="middle" x="2940" y="-478.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
<text text-anchor="middle" x="2940" y="-466.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0006164 -->
<g id="node27" class="node"><title>GO:0006164</title>
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<polygon style="fill:none;stroke:black;" points="2795,-388 2795,-430 2875,-430 2875,-388 2795,-388"/>
<text text-anchor="middle" x="2835" y="-419.667" style="font-family:Arial;font-size:10px;">purine nucleotide</text>
<text text-anchor="middle" x="2835" y="-407.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2835" y="-395.667" style="font-family:Arial;font-size:10px;">process</text>
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<text text-anchor="middle" x="2835" y="-377.667" style="font-family:Arial;font-size:10px;">Dicty: ISS_only</text>
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<text text-anchor="middle" x="2835" y="-361.667" style="font-family:Arial;font-size:10px;">Rat: ISS_only</text>
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<text text-anchor="middle" x="2835" y="-345.667" style="font-family:Arial;font-size:10px;">Yeast</text>
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<text text-anchor="middle" x="2835" y="-329.667" style="font-family:Arial;font-size:10px;">Ecoli</text>
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<text text-anchor="middle" x="2835" y="-297.667" style="font-family:Arial;font-size:10px;">Pombe</text>
</g>
<!-- GO:0006163&#45;&gt;GO:0006164 -->
<g id="edge179" class="edge"><title>GO:0006163&#45;&gt;GO:0006164</title>
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<polygon style="fill:gray;stroke:gray;" points="2898.9,-455.8 2909,-459 2903.1,-450.2 2898.9,-455.8"/>
</g>
<!-- GO:0009126 -->
<g id="node84" class="node"><title>GO:0009126</title>
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<polygon style="fill:none;stroke:black;" points="2909,-340 2909,-382 2995,-382 2995,-340 2909,-340"/>
<text text-anchor="middle" x="2952" y="-371.667" style="font-family:Arial;font-size:10px;">purine nucleoside</text>
<text text-anchor="middle" x="2952" y="-359.667" style="font-family:Arial;font-size:10px;">monophosphate</text>
<text text-anchor="middle" x="2952" y="-347.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0006163&#45;&gt;GO:0009126 -->
<g id="edge201" class="edge"><title>GO:0006163&#45;&gt;GO:0009126</title>
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</g>
<!-- GO:0009150 -->
<g id="node86" class="node"><title>GO:0009150</title>
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<polygon style="fill:none;stroke:black;" points="3029,-346 3029,-376 3125,-376 3125,-346 3029,-346"/>
<text text-anchor="middle" x="3077" y="-365.667" style="font-family:Arial;font-size:10px;">purine ribonucleotide</text>
<text text-anchor="middle" x="3077" y="-353.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0006163&#45;&gt;GO:0009150 -->
<g id="edge211" class="edge"><title>GO:0006163&#45;&gt;GO:0009150</title>
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</g>
<!-- GO:0005624 -->
<g id="node17" class="node"><title>GO:0005624</title>
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<text text-anchor="middle" x="640" y="-654.667" style="font-family:Arial;font-size:10px;">membrane fraction</text>
<text text-anchor="middle" x="640" y="-642.667" style="font-family:Arial;font-size:10px;">Ecoli</text>
</g>
<!-- GO:0040010 -->
<g id="node18" class="node"><title>GO:0040010</title>
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<text text-anchor="middle" x="2041" y="-648.667" style="font-family:Arial;font-size:10px;">of growth rate</text>
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</g>
<!-- GO:0045335 -->
<g id="node19" class="node"><title>GO:0045335</title>
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<text text-anchor="middle" x="1167" y="-139.667" style="font-family:Arial;font-size:10px;">phagocytic vesicle</text>
<text text-anchor="middle" x="1167" y="-127.667" style="font-family:Arial;font-size:10px;">Dicty</text>
</g>
<!-- GO:0005634 -->
<g id="node20" class="node"><title>GO:0005634</title>
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<text text-anchor="middle" x="1111" y="-484.667" style="font-family:Arial;font-size:10px;">nucleus</text>
<text text-anchor="middle" x="1111" y="-472.667" style="font-family:Arial;font-size:10px;">Pombe</text>
</g>
<!-- GO:0009078 -->
<g id="node21" class="node"><title>GO:0009078</title>
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<text text-anchor="middle" x="2776" y="-573.667" style="font-family:Arial;font-size:10px;">pyruvate family</text>
<text text-anchor="middle" x="2776" y="-561.667" style="font-family:Arial;font-size:10px;">amino acid metabolic</text>
<text text-anchor="middle" x="2776" y="-549.667" style="font-family:Arial;font-size:10px;">process</text>
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</g>
<!-- GO:0005515 -->
<g id="node22" class="node"><title>GO:0005515</title>
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<text text-anchor="middle" x="161" y="-1013.67" style="font-family:Arial;font-size:10px;">protein binding</text>
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<text text-anchor="middle" x="161" y="-981.667" style="font-family:Arial;font-size:10px;">Mouse</text>
</g>
<!-- GO:0042802 -->
<g id="node124" class="node"><title>GO:0042802</title>
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<text text-anchor="middle" x="45" y="-921.667" style="font-family:Arial;font-size:10px;">identical protein</text>
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<!-- GO:0005515&#45;&gt;GO:0042802 -->
<g id="edge361" class="edge"><title>GO:0005515&#45;&gt;GO:0042802</title>
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</g>
<!-- GO:0046983 -->
<g id="node125" class="node"><title>GO:0046983</title>
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<text text-anchor="middle" x="161" y="-921.667" style="font-family:Arial;font-size:10px;">protein dimerization</text>
<text text-anchor="middle" x="161" y="-909.667" style="font-family:Arial;font-size:10px;">activity</text>
</g>
<!-- GO:0005515&#45;&gt;GO:0046983 -->
<g id="edge365" class="edge"><title>GO:0005515&#45;&gt;GO:0046983</title>
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</g>
<!-- GO:0042803 -->
<g id="node23" class="node"><title>GO:0042803</title>
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<text text-anchor="middle" x="75" y="-797.667" style="font-family:Arial;font-size:10px;">protein homodimerization</text>
<text text-anchor="middle" x="75" y="-785.667" style="font-family:Arial;font-size:10px;">activity</text>
<text text-anchor="middle" x="75" y="-773.667" style="font-family:Arial;font-size:10px;">Pombe: ISS_only</text>
</g>
<!-- GO:0040035 -->
<g id="node24" class="node"><title>GO:0040035</title>
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<text text-anchor="middle" x="1384" y="-567.667" style="font-family:Arial;font-size:10px;">hermaphrodite</text>
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<g id="edge379" class="edge"><title>GO:0000003&#45;&gt;GO:0022414</title>
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<g id="edge177" class="edge"><title>GO:0006164&#45;&gt;GO:0009127</title>
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<g id="edge207" class="edge"><title>GO:0006164&#45;&gt;GO:0009152</title>
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<g id="edge23" class="edge"><title>GO:0005737&#45;&gt;GO:0044444</title>
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<g id="node29" class="node"><title>GO:0046086</title>
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<g id="edge3" class="edge"><title>GO:0009532&#45;&gt;GO:0009570</title>
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<g id="edge5" class="edge"><title>GO:0044435&#45;&gt;GO:0009532</title>
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<g id="edge59" class="edge"><title>GO:0044435&#45;&gt;GO:0044434</title>
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<g id="edge385" class="edge"><title>GO:0044444&#45;&gt;GO:0005829</title>
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<g id="edge7" class="edge"><title>GO:0044444&#45;&gt;GO:0044435</title>
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<g id="node42" class="node"><title>GO:0009536</title>
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<g id="edge55" class="edge"><title>GO:0044444&#45;&gt;GO:0009536</title>
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<g id="node114" class="node"><title>GO:0031410</title>
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<g id="edge323" class="edge"><title>GO:0044444&#45;&gt;GO:0031410</title>
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<g id="edge25" class="edge"><title>GO:0044424&#45;&gt;GO:0005737</title>
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<g id="edge9" class="edge"><title>GO:0044424&#45;&gt;GO:0044444</title>
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<g id="node38" class="node"><title>GO:0044446</title>
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<g id="edge37" class="edge"><title>GO:0044424&#45;&gt;GO:0044446</title>
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<g id="edge43" class="edge"><title>GO:0044424&#45;&gt;GO:0043229</title>
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<g id="edge11" class="edge"><title>GO:0044464&#45;&gt;GO:0044424</title>
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<g id="edge21" class="edge"><title>GO:0044464&#45;&gt;GO:0005622</title>
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<g id="edge287" class="edge"><title>GO:0044464&#45;&gt;GO:0000267</title>
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<g id="edge15" class="edge"><title>GO:0005623&#45;&gt;GO:0044464</title>
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<g id="edge19" class="edge"><title>GO:0005622&#45;&gt;GO:0044424</title>
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<g id="edge27" class="edge"><title>GO:0044446&#45;&gt;GO:0044435</title>
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<g id="edge29" class="edge"><title>GO:0044422&#45;&gt;GO:0044446</title>
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<g id="edge33" class="edge"><title>GO:0043226&#45;&gt;GO:0044422</title>
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<g id="edge41" class="edge"><title>GO:0043226&#45;&gt;GO:0043229</title>
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<g id="edge51" class="edge"><title>GO:0043226&#45;&gt;GO:0043227</title>
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<g id="edge319" class="edge"><title>GO:0043226&#45;&gt;GO:0031982</title>
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<g id="edge53" class="edge"><title>GO:0043229&#45;&gt;GO:0043231</title>
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<g id="edge329" class="edge"><title>GO:0043231&#45;&gt;GO:0016023</title>
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<g id="edge49" class="edge"><title>GO:0043227&#45;&gt;GO:0043231</title>
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<g id="edge57" class="edge"><title>GO:0044434&#45;&gt;GO:0009570</title>
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<g id="edge65" class="edge"><title>GO:0040028&#45;&gt;GO:0040027</title>
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<g id="edge67" class="edge"><title>GO:0048580&#45;&gt;GO:0040028</title>
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<g id="edge69" class="edge"><title>GO:0050793&#45;&gt;GO:0048580</title>
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<g id="edge129" class="edge"><title>GO:0050793&#45;&gt;GO:0051093</title>
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<g id="edge71" class="edge"><title>GO:0050789&#45;&gt;GO:0050793</title>
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<g id="edge85" class="edge"><title>GO:0050789&#45;&gt;GO:0051239</title>
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<g id="edge79" class="edge"><title>GO:0032502&#45;&gt;GO:0050793</title>
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<g id="edge93" class="edge"><title>GO:0032502&#45;&gt;GO:0009791</title>
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<g id="edge99" class="edge"><title>GO:0032502&#45;&gt;GO:0007275</title>
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<g id="edge253" class="edge"><title>GO:0032502&#45;&gt;GO:0009790</title>
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<g id="edge119" class="edge"><title>GO:0009791&#45;&gt;GO:0002164</title>
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<g id="edge113" class="edge"><title>GO:0007275&#45;&gt;GO:0048731</title>
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<g id="edge255" class="edge"><title>GO:0007275&#45;&gt;GO:0009790</title>
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<!-- GO:0040025 -->
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<!-- GO:0040025&#45;&gt;GO:0040027 -->
<g id="edge133" class="edge"><title>GO:0040025&#45;&gt;GO:0040027</title>
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<!-- GO:0040025&#45;&gt;GO:0040028 -->
<g id="edge101" class="edge"><title>GO:0040025&#45;&gt;GO:0040028</title>
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<g id="node57" class="node"><title>GO:0048513</title>
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<!-- GO:0048513&#45;&gt;GO:0040025 -->
<g id="edge103" class="edge"><title>GO:0048513&#45;&gt;GO:0040025</title>
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<!-- GO:0048513&#45;&gt;GO:0048806 -->
<g id="edge369" class="edge"><title>GO:0048513&#45;&gt;GO:0048806</title>
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<g id="edge105" class="edge"><title>GO:0048856&#45;&gt;GO:0048513</title>
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<!-- GO:0048856&#45;&gt;GO:0048731 -->
<g id="edge111" class="edge"><title>GO:0048856&#45;&gt;GO:0048731</title>
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<!-- GO:0048731&#45;&gt;GO:0048513 -->
<g id="edge109" class="edge"><title>GO:0048731&#45;&gt;GO:0048513</title>
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<!-- GO:0002119 -->
<g id="node60" class="node"><title>GO:0002119</title>
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<text text-anchor="middle" x="1557" y="-654.667" style="font-family:Arial;font-size:10px;">nematode larval</text>
<text text-anchor="middle" x="1557" y="-642.667" style="font-family:Arial;font-size:10px;">development</text>
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<!-- GO:0002119&#45;&gt;GO:0040025 -->
<g id="edge115" class="edge"><title>GO:0002119&#45;&gt;GO:0040025</title>
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<!-- GO:0002164&#45;&gt;GO:0002119 -->
<g id="edge117" class="edge"><title>GO:0002164&#45;&gt;GO:0002119</title>
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<!-- GO:0051093&#45;&gt;GO:0040027 -->
<g id="edge121" class="edge"><title>GO:0051093&#45;&gt;GO:0040027</title>
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<!-- GO:0048519&#45;&gt;GO:0051093 -->
<g id="edge123" class="edge"><title>GO:0048519&#45;&gt;GO:0051093</title>
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<!-- GO:0032561 -->
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<text text-anchor="middle" x="303" y="-654.667" style="font-family:Arial;font-size:10px;">guanyl ribonucleotide</text>
<text text-anchor="middle" x="303" y="-642.667" style="font-family:Arial;font-size:10px;">binding</text>
</g>
<!-- GO:0032561&#45;&gt;GO:0005525 -->
<g id="edge135" class="edge"><title>GO:0032561&#45;&gt;GO:0005525</title>
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<!-- GO:0019001 -->
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<polygon style="fill:none;stroke:black;" points="201,-772 201,-802 283,-802 283,-772 201,-772"/>
<text text-anchor="middle" x="242" y="-791.667" style="font-family:Arial;font-size:10px;">guanyl nucleotide</text>
<text text-anchor="middle" x="242" y="-779.667" style="font-family:Arial;font-size:10px;">binding</text>
</g>
<!-- GO:0019001&#45;&gt;GO:0032561 -->
<g id="edge137" class="edge"><title>GO:0019001&#45;&gt;GO:0032561</title>
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</g>
<!-- GO:0017076 -->
<g id="node66" class="node"><title>GO:0017076</title>
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<polygon style="fill:none;stroke:black;" points="240,-902 240,-932 320,-932 320,-902 240,-902"/>
<text text-anchor="middle" x="280" y="-921.667" style="font-family:Arial;font-size:10px;">purine nucleotide</text>
<text text-anchor="middle" x="280" y="-909.667" style="font-family:Arial;font-size:10px;">binding</text>
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<!-- GO:0017076&#45;&gt;GO:0019001 -->
<g id="edge139" class="edge"><title>GO:0017076&#45;&gt;GO:0019001</title>
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<!-- GO:0032555 -->
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<polygon style="fill:none;stroke:black;" points="317,-772 317,-802 413,-802 413,-772 317,-772"/>
<text text-anchor="middle" x="365" y="-791.667" style="font-family:Arial;font-size:10px;">purine ribonucleotide</text>
<text text-anchor="middle" x="365" y="-779.667" style="font-family:Arial;font-size:10px;">binding</text>
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<!-- GO:0017076&#45;&gt;GO:0032555 -->
<g id="edge149" class="edge"><title>GO:0017076&#45;&gt;GO:0032555</title>
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<g id="node67" class="node"><title>GO:0000166</title>
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<polygon style="fill:none;stroke:black;" points="341,-992 341,-1008 425,-1008 425,-992 341,-992"/>
<text text-anchor="middle" x="383" y="-997.667" style="font-family:Arial;font-size:10px;">nucleotide binding</text>
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<!-- GO:0000166&#45;&gt;GO:0017076 -->
<g id="edge141" class="edge"><title>GO:0000166&#45;&gt;GO:0017076</title>
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<!-- GO:0032553 -->
<g id="node70" class="node"><title>GO:0032553</title>
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<text text-anchor="middle" x="387" y="-921.667" style="font-family:Arial;font-size:10px;">ribonucleotide</text>
<text text-anchor="middle" x="387" y="-909.667" style="font-family:Arial;font-size:10px;">binding</text>
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<!-- GO:0000166&#45;&gt;GO:0032553 -->
<g id="edge153" class="edge"><title>GO:0000166&#45;&gt;GO:0032553</title>
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<!-- GO:0005488&#45;&gt;GO:0005515 -->
<g id="edge357" class="edge"><title>GO:0005488&#45;&gt;GO:0005515</title>
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<!-- GO:0005488&#45;&gt;GO:0000166 -->
<g id="edge143" class="edge"><title>GO:0005488&#45;&gt;GO:0000166</title>
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<!-- GO:0005488&#45;&gt;GO:0003676 -->
<g id="edge281" class="edge"><title>GO:0005488&#45;&gt;GO:0003676</title>
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<!-- GO:0032555&#45;&gt;GO:0032561 -->
<g id="edge147" class="edge"><title>GO:0032555&#45;&gt;GO:0032561</title>
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<!-- GO:0032553&#45;&gt;GO:0032555 -->
<g id="edge151" class="edge"><title>GO:0032553&#45;&gt;GO:0032555</title>
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<text text-anchor="middle" x="2418" y="-791.667" style="font-family:Arial;font-size:10px;">nucleoside and</text>
<text text-anchor="middle" x="2418" y="-779.667" style="font-family:Arial;font-size:10px;">nucleotide metabolic</text>
<text text-anchor="middle" x="2418" y="-767.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0055086&#45;&gt;GO:0015949 -->
<g id="edge155" class="edge"><title>GO:0055086&#45;&gt;GO:0015949</title>
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<!-- GO:0055086&#45;&gt;GO:0006753 -->
<g id="edge185" class="edge"><title>GO:0055086&#45;&gt;GO:0006753</title>
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<!-- GO:0055086&#45;&gt;GO:0009116 -->
<g id="edge395" class="edge"><title>GO:0055086&#45;&gt;GO:0009116</title>
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<text text-anchor="middle" x="2193" y="-642.667" style="font-family:Arial;font-size:10px;">nucleotide biosynthetic</text>
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<!-- GO:0055086&#45;&gt;GO:0034404 -->
<g id="edge423" class="edge"><title>GO:0055086&#45;&gt;GO:0034404</title>
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<text text-anchor="middle" x="2418" y="-927.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="2418" y="-915.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
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<g id="edge157" class="edge"><title>GO:0006139&#45;&gt;GO:0055086</title>
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<text text-anchor="middle" x="2295" y="-815.667" style="font-family:Arial;font-size:10px;">nucleobase,</text>
<text text-anchor="middle" x="2295" y="-803.667" style="font-family:Arial;font-size:10px;">nucleoside,</text>
<text text-anchor="middle" x="2295" y="-791.667" style="font-family:Arial;font-size:10px;">nucleotide and</text>
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<!-- GO:0006139&#45;&gt;GO:0034654 -->
<g id="edge413" class="edge"><title>GO:0006139&#45;&gt;GO:0034654</title>
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<!-- GO:0044237&#45;&gt;GO:0006139 -->
<g id="edge159" class="edge"><title>GO:0044237&#45;&gt;GO:0006139</title>
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<text text-anchor="middle" x="2538" y="-915.667" style="font-family:Arial;font-size:10px;">acid and derivative</text>
<text text-anchor="middle" x="2538" y="-903.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
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<!-- GO:0044237&#45;&gt;GO:0006519 -->
<g id="edge337" class="edge"><title>GO:0044237&#45;&gt;GO:0006519</title>
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<text text-anchor="middle" x="2783" y="-927.667" style="font-family:Arial;font-size:10px;">cellular nitrogen</text>
<text text-anchor="middle" x="2783" y="-915.667" style="font-family:Arial;font-size:10px;">compound metabolic</text>
<text text-anchor="middle" x="2783" y="-903.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0044237&#45;&gt;GO:0034641 -->
<g id="edge349" class="edge"><title>GO:0044237&#45;&gt;GO:0034641</title>
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<!-- GO:0006082 -->
<g id="node123" class="node"><title>GO:0006082</title>
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<polygon style="fill:none;stroke:black;" points="2615,-902 2615,-932 2701,-932 2701,-902 2615,-902"/>
<text text-anchor="middle" x="2658" y="-921.667" style="font-family:Arial;font-size:10px;">organic acid</text>
<text text-anchor="middle" x="2658" y="-909.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0044237&#45;&gt;GO:0006082 -->
<g id="edge355" class="edge"><title>GO:0044237&#45;&gt;GO:0006082</title>
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<!-- GO:0044249 -->
<g id="node140" class="node"><title>GO:0044249</title>
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<text text-anchor="middle" x="2295" y="-921.667" style="font-family:Arial;font-size:10px;">cellular biosynthetic</text>
<text text-anchor="middle" x="2295" y="-909.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0044237&#45;&gt;GO:0044249 -->
<g id="edge421" class="edge"><title>GO:0044237&#45;&gt;GO:0044249</title>
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<!-- GO:0008152&#45;&gt;GO:0044237 -->
<g id="edge161" class="edge"><title>GO:0008152&#45;&gt;GO:0044237</title>
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<!-- GO:0044238 -->
<g id="node76" class="node"><title>GO:0044238</title>
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<text text-anchor="middle" x="2418" y="-1004.67" style="font-family:Arial;font-size:10px;">primary metabolic</text>
<text text-anchor="middle" x="2418" y="-992.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0044238 -->
<g id="edge171" class="edge"><title>GO:0008152&#45;&gt;GO:0044238</title>
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<!-- GO:0006807 -->
<g id="node121" class="node"><title>GO:0006807</title>
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<text text-anchor="middle" x="2718" y="-1004.67" style="font-family:Arial;font-size:10px;">nitrogen compound</text>
<text text-anchor="middle" x="2718" y="-992.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0006807 -->
<g id="edge347" class="edge"><title>GO:0008152&#45;&gt;GO:0006807</title>
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<g id="node141" class="node"><title>GO:0009058</title>
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<polygon style="fill:none;stroke:black;" points="2275,-985 2275,-1015 2333,-1015 2333,-985 2275,-985"/>
<text text-anchor="middle" x="2304" y="-1004.67" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2304" y="-992.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0008152&#45;&gt;GO:0009058 -->
<g id="edge419" class="edge"><title>GO:0008152&#45;&gt;GO:0009058</title>
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<!-- GO:0009987&#45;&gt;GO:0044237 -->
<g id="edge165" class="edge"><title>GO:0009987&#45;&gt;GO:0044237</title>
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<polygon style="fill:gray;stroke:gray;" points="2530.51,-1046.7 2533,-1057 2537.48,-1047.4 2530.51,-1046.7"/>
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<!-- GO:0044238&#45;&gt;GO:0006139 -->
<g id="edge169" class="edge"><title>GO:0044238&#45;&gt;GO:0006139</title>
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<!-- GO:0044238&#45;&gt;GO:0006519 -->
<g id="edge339" class="edge"><title>GO:0044238&#45;&gt;GO:0006519</title>
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<polygon style="fill:gray;stroke:gray;" points="2445.9,-976.2 2440,-985 2450.1,-981.8 2445.9,-976.2"/>
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<!-- GO:0009168 -->
<g id="node77" class="node"><title>GO:0009168</title>
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<polygon style="fill:none;stroke:black;" points="2790,-108 2790,-162 2888,-162 2888,-108 2790,-108"/>
<text text-anchor="middle" x="2839" y="-151.667" style="font-family:Arial;font-size:10px;">purine ribonucleoside</text>
<text text-anchor="middle" x="2839" y="-139.667" style="font-family:Arial;font-size:10px;">monophosphate</text>
<text text-anchor="middle" x="2839" y="-127.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2839" y="-115.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0009168&#45;&gt;GO:0006167 -->
<g id="edge173" class="edge"><title>GO:0009168&#45;&gt;GO:0006167</title>
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<!-- GO:0009127&#45;&gt;GO:0009168 -->
<g id="edge175" class="edge"><title>GO:0009127&#45;&gt;GO:0009168</title>
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<!-- GO:0009117 -->
<g id="node79" class="node"><title>GO:0009117</title>
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<polygon style="fill:none;stroke:black;" points="2597,-542 2597,-572 2693,-572 2693,-542 2597,-542"/>
<text text-anchor="middle" x="2645" y="-561.667" style="font-family:Arial;font-size:10px;">nucleotide metabolic</text>
<text text-anchor="middle" x="2645" y="-549.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0009117&#45;&gt;GO:0006163 -->
<g id="edge181" class="edge"><title>GO:0009117&#45;&gt;GO:0006163</title>
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<!-- GO:0009165 -->
<g id="node81" class="node"><title>GO:0009165</title>
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<polygon style="fill:none;stroke:black;" points="2454,-465 2454,-495 2560,-495 2560,-465 2454,-465"/>
<text text-anchor="middle" x="2507" y="-484.667" style="font-family:Arial;font-size:10px;">nucleotide biosynthetic</text>
<text text-anchor="middle" x="2507" y="-472.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009117&#45;&gt;GO:0009165 -->
<g id="edge189" class="edge"><title>GO:0009117&#45;&gt;GO:0009165</title>
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<!-- GO:0009123 -->
<g id="node83" class="node"><title>GO:0009123</title>
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<text text-anchor="middle" x="2656" y="-484.667" style="font-family:Arial;font-size:10px;">nucleoside monophosphate</text>
<text text-anchor="middle" x="2656" y="-472.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0009117&#45;&gt;GO:0009123 -->
<g id="edge195" class="edge"><title>GO:0009117&#45;&gt;GO:0009123</title>
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<!-- GO:0009259 -->
<g id="node87" class="node"><title>GO:0009259</title>
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<text text-anchor="middle" x="2795" y="-484.667" style="font-family:Arial;font-size:10px;">ribonucleotide</text>
<text text-anchor="middle" x="2795" y="-472.667" style="font-family:Arial;font-size:10px;">metabolic process</text>
</g>
<!-- GO:0009117&#45;&gt;GO:0009259 -->
<g id="edge215" class="edge"><title>GO:0009117&#45;&gt;GO:0009259</title>
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<!-- GO:0006753&#45;&gt;GO:0009117 -->
<g id="edge183" class="edge"><title>GO:0006753&#45;&gt;GO:0009117</title>
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<!-- GO:0009165&#45;&gt;GO:0006164 -->
<g id="edge187" class="edge"><title>GO:0009165&#45;&gt;GO:0006164</title>
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<!-- GO:0009124 -->
<g id="node82" class="node"><title>GO:0009124</title>
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<text text-anchor="middle" x="2479" y="-371.667" style="font-family:Arial;font-size:10px;">nucleoside monophosphate</text>
<text text-anchor="middle" x="2479" y="-359.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2479" y="-347.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0009165&#45;&gt;GO:0009124 -->
<g id="edge197" class="edge"><title>GO:0009165&#45;&gt;GO:0009124</title>
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<!-- GO:0009260 -->
<g id="node88" class="node"><title>GO:0009260</title>
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<polygon style="fill:none;stroke:black;" points="2575,-340 2575,-382 2641,-382 2641,-340 2575,-340"/>
<text text-anchor="middle" x="2608" y="-371.667" style="font-family:Arial;font-size:10px;">ribonucleotide</text>
<text text-anchor="middle" x="2608" y="-359.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2608" y="-347.667" style="font-family:Arial;font-size:10px;">process</text>
</g>
<!-- GO:0009165&#45;&gt;GO:0009260 -->
<g id="edge219" class="edge"><title>GO:0009165&#45;&gt;GO:0009260</title>
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<!-- GO:0009124&#45;&gt;GO:0009127 -->
<g id="edge191" class="edge"><title>GO:0009124&#45;&gt;GO:0009127</title>
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<!-- GO:0009156 -->
<g id="node89" class="node"><title>GO:0009156</title>
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<text text-anchor="middle" x="2603" y="-243.667" style="font-family:Arial;font-size:10px;">ribonucleoside</text>
<text text-anchor="middle" x="2603" y="-231.667" style="font-family:Arial;font-size:10px;">monophosphate</text>
<text text-anchor="middle" x="2603" y="-219.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
<text text-anchor="middle" x="2603" y="-207.667" style="font-family:Arial;font-size:10px;">process</text>
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<!-- GO:0009124&#45;&gt;GO:0009156 -->
<g id="edge225" class="edge"><title>GO:0009124&#45;&gt;GO:0009156</title>
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<!-- GO:0009123&#45;&gt;GO:0009124 -->
<g id="edge193" class="edge"><title>GO:0009123&#45;&gt;GO:0009124</title>
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<!-- GO:0009123&#45;&gt;GO:0009126 -->
<g id="edge203" class="edge"><title>GO:0009123&#45;&gt;GO:0009126</title>
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<text text-anchor="middle" x="2718" y="-371.667" style="font-family:Arial;font-size:10px;">ribonucleoside</text>
<text text-anchor="middle" x="2718" y="-359.667" style="font-family:Arial;font-size:10px;">monophosphate</text>
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<!-- GO:0009123&#45;&gt;GO:0009161 -->
<g id="edge229" class="edge"><title>GO:0009123&#45;&gt;GO:0009161</title>
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<!-- GO:0009126&#45;&gt;GO:0009127 -->
<g id="edge199" class="edge"><title>GO:0009126&#45;&gt;GO:0009127</title>
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<!-- GO:0009126&#45;&gt;GO:0009167 -->
<g id="edge237" class="edge"><title>GO:0009126&#45;&gt;GO:0009167</title>
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<!-- GO:0009152&#45;&gt;GO:0009168 -->
<g id="edge205" class="edge"><title>GO:0009152&#45;&gt;GO:0009168</title>
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<g id="edge209" class="edge"><title>GO:0009150&#45;&gt;GO:0009152</title>
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<g id="edge239" class="edge"><title>GO:0009150&#45;&gt;GO:0009167</title>
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<g id="edge213" class="edge"><title>GO:0009259&#45;&gt;GO:0009150</title>
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<g id="edge217" class="edge"><title>GO:0009260&#45;&gt;GO:0009152</title>
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<g id="edge233" class="edge"><title>GO:0009260&#45;&gt;GO:0009156</title>
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<g id="edge235" class="edge"><title>GO:0009167&#45;&gt;GO:0009168</title>
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<text text-anchor="middle" x="2964" y="-139.667" style="font-family:Arial;font-size:10px;">AMP metabolic</text>
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<!-- GO:0009167&#45;&gt;GO:0046033 -->
<g id="edge245" class="edge"><title>GO:0009167&#45;&gt;GO:0046033</title>
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<g id="edge243" class="edge"><title>GO:0046033&#45;&gt;GO:0006167</title>
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<g id="edge247" class="edge"><title>GO:0005576&#45;&gt;GO:0048046</title>
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<!-- GO:0009790&#45;&gt;GO:0009792 -->
<g id="edge251" class="edge"><title>GO:0009790&#45;&gt;GO:0009792</title>
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<polygon style="fill:none;stroke:black;" points="552,-896 552,-938 660,-938 660,-896 552,-896"/>
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<text text-anchor="middle" x="606" y="-915.667" style="font-family:Arial;font-size:10px;">forming carbon&#45;nitrogen</text>
<text text-anchor="middle" x="606" y="-903.667" style="font-family:Arial;font-size:10px;">bonds</text>
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<!-- GO:0016879&#45;&gt;GO:0004019 -->
<g id="edge257" class="edge"><title>GO:0016879&#45;&gt;GO:0004019</title>
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<!-- GO:0016874 -->
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<polygon style="fill:none;stroke:black;" points="563,-992 563,-1008 627,-1008 627,-992 563,-992"/>
<text text-anchor="middle" x="595" y="-997.667" style="font-family:Arial;font-size:10px;">ligase activity</text>
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<!-- GO:0016874&#45;&gt;GO:0016879 -->
<g id="edge259" class="edge"><title>GO:0016874&#45;&gt;GO:0016879</title>
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<!-- GO:0003824&#45;&gt;GO:0016874 -->
<g id="edge261" class="edge"><title>GO:0003824&#45;&gt;GO:0016874</title>
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<polygon style="fill:gray;stroke:gray;" points="565.863,-1046.44 565,-1057 572.26,-1049.28 565.863,-1046.44"/>
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<!-- GO:0010038 -->
<g id="node98" class="node"><title>GO:0010038</title>
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<text text-anchor="middle" x="2912" y="-791.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="2912" y="-779.667" style="font-family:Arial;font-size:10px;">metal ion</text>
</g>
<!-- GO:0010038&#45;&gt;GO:0046686 -->
<g id="edge265" class="edge"><title>GO:0010038&#45;&gt;GO:0046686</title>
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<!-- GO:0010035 -->
<g id="node99" class="node"><title>GO:0010035</title>
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<text text-anchor="middle" x="2912" y="-921.667" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="2912" y="-909.667" style="font-family:Arial;font-size:10px;">inorganic substance</text>
</g>
<!-- GO:0010035&#45;&gt;GO:0010038 -->
<g id="edge267" class="edge"><title>GO:0010035&#45;&gt;GO:0010038</title>
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<polygon style="fill:gray;stroke:gray;" points="2908.5,-892 2912,-902 2915.5,-892 2908.5,-892"/>
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<!-- GO:0042221 -->
<g id="node100" class="node"><title>GO:0042221</title>
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<polygon style="fill:none;stroke:black;" points="2833,-985 2833,-1015 2917,-1015 2917,-985 2833,-985"/>
<text text-anchor="middle" x="2875" y="-1004.67" style="font-family:Arial;font-size:10px;">response to</text>
<text text-anchor="middle" x="2875" y="-992.667" style="font-family:Arial;font-size:10px;">chemical stimulus</text>
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<!-- GO:0042221&#45;&gt;GO:0010035 -->
<g id="edge269" class="edge"><title>GO:0042221&#45;&gt;GO:0010035</title>
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<!-- GO:0050896&#45;&gt;GO:0042221 -->
<g id="edge271" class="edge"><title>GO:0050896&#45;&gt;GO:0042221</title>
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<text text-anchor="middle" x="489" y="-779.667" style="font-family:Arial;font-size:10px;">DNA binding</text>
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<!-- GO:0043565&#45;&gt;GO:0003688 -->
<g id="edge275" class="edge"><title>GO:0043565&#45;&gt;GO:0003688</title>
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<!-- GO:0003677 -->
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<polygon style="fill:none;stroke:black;" points="458,-909 458,-925 518,-925 518,-909 458,-909"/>
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<!-- GO:0003677&#45;&gt;GO:0043565 -->
<g id="edge277" class="edge"><title>GO:0003677&#45;&gt;GO:0043565</title>
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<!-- GO:0003676&#45;&gt;GO:0003677 -->
<g id="edge279" class="edge"><title>GO:0003676&#45;&gt;GO:0003677</title>
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<!-- GO:0005626 -->
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<polygon style="fill:none;stroke:black;" points="682,-779 682,-795 760,-795 760,-779 682,-779"/>
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<!-- GO:0005626&#45;&gt;GO:0005624 -->
<g id="edge283" class="edge"><title>GO:0005626&#45;&gt;GO:0005624</title>
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<g id="edge285" class="edge"><title>GO:0000267&#45;&gt;GO:0005626</title>
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<polygon style="fill:none;stroke:black;" points="2001,-772 2001,-802 2059,-802 2059,-772 2001,-772"/>
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<text text-anchor="middle" x="2030" y="-779.667" style="font-family:Arial;font-size:10px;">growth rate</text>
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<!-- GO:0040009&#45;&gt;GO:0040010 -->
<g id="edge289" class="edge"><title>GO:0040009&#45;&gt;GO:0040010</title>
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<g id="edge291" class="edge"><title>GO:0040008&#45;&gt;GO:0040009</title>
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<!-- GO:0040008&#45;&gt;GO:0045927 -->
<g id="edge301" class="edge"><title>GO:0040008&#45;&gt;GO:0045927</title>
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<g id="edge295" class="edge"><title>GO:0040007&#45;&gt;GO:0040008</title>
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<g id="edge309" class="edge"><title>GO:0040007&#45;&gt;GO:0045927</title>
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<g id="edge299" class="edge"><title>GO:0045927&#45;&gt;GO:0040010</title>
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<g id="edge303" class="edge"><title>GO:0048518&#45;&gt;GO:0045927</title>
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<!-- GO:0030139&#45;&gt;GO:0045335 -->
<g id="edge311" class="edge"><title>GO:0030139&#45;&gt;GO:0045335</title>
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<g id="edge315" class="edge"><title>GO:0031410&#45;&gt;GO:0016023</title>
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<g id="edge317" class="edge"><title>GO:0031982&#45;&gt;GO:0031410</title>
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<text text-anchor="middle" x="1249" y="-484.667" style="font-family:Arial;font-size:10px;">membrane&#45;bounded</text>
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<!-- GO:0031982&#45;&gt;GO:0031988 -->
<g id="edge327" class="edge"><title>GO:0031982&#45;&gt;GO:0031988</title>
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<g id="edge325" class="edge"><title>GO:0031988&#45;&gt;GO:0016023</title>
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<!-- GO:0006520&#45;&gt;GO:0009078 -->
<g id="edge333" class="edge"><title>GO:0006520&#45;&gt;GO:0009078</title>
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<g id="edge335" class="edge"><title>GO:0006519&#45;&gt;GO:0006520</title>
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<g id="edge351" class="edge"><title>GO:0019752&#45;&gt;GO:0006520</title>
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<g id="edge353" class="edge"><title>GO:0006082&#45;&gt;GO:0019752</title>
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<g id="edge363" class="edge"><title>GO:0046983&#45;&gt;GO:0042803</title>
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<!-- GO:0007548&#45;&gt;GO:0048806 -->
<g id="edge371" class="edge"><title>GO:0007548&#45;&gt;GO:0048806</title>
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<g id="edge373" class="edge"><title>GO:0003006&#45;&gt;GO:0007548</title>
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<g id="edge375" class="edge"><title>GO:0022414&#45;&gt;GO:0003006</title>
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<g id="edge387" class="edge"><title>GO:0046085&#45;&gt;GO:0046086</title>
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<text text-anchor="middle" x="2341" y="-484.667" style="font-family:Arial;font-size:10px;">purine ribonucleoside</text>
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<!-- GO:0046128&#45;&gt;GO:0046085 -->
<g id="edge389" class="edge"><title>GO:0046128&#45;&gt;GO:0046085</title>
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<!-- GO:0046128&#45;&gt;GO:0046129 -->
<g id="edge433" class="edge"><title>GO:0046128&#45;&gt;GO:0046129</title>
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<!-- GO:0009119&#45;&gt;GO:0046128 -->
<g id="edge391" class="edge"><title>GO:0009119&#45;&gt;GO:0046128</title>
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<text text-anchor="middle" x="2224" y="-478.667" style="font-family:Arial;font-size:10px;">biosynthetic</text>
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<g id="edge429" class="edge"><title>GO:0009119&#45;&gt;GO:0042455</title>
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<g id="edge393" class="edge"><title>GO:0009116&#45;&gt;GO:0009119</title>
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<g id="edge399" class="edge"><title>GO:0009116&#45;&gt;GO:0042278</title>
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<g id="edge407" class="edge"><title>GO:0009116&#45;&gt;GO:0009163</title>
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<g id="edge397" class="edge"><title>GO:0042278&#45;&gt;GO:0046128</title>
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