Compare GO annotations for POLA and its Reference Genomes orthologs

Compare GO annotations for POLA and its orthologs

Possible outliers might be spotted in a summary/comparison table of high level GO categories.
Complete table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: human, mouse, rat, chicken, zfish, fly, worm, dicty, dicot, yeast, pombe, ecoli.
Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Red arrows indicate "regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Chicken from GOA; Zfish from Zfin; Fly from Flybase; Worm from Wormbase; Dicot from TAIR; Dicty from Dictybase; Yeast from SGD; Pombe from Sanger; Ecoli from EcoliHub.
Organisms with experimental annotations are indicated: IC, IDA, IEP, IGI, IMP, IPI. In addition, ISS annotations are so indicated.
Does not include evidence codes: IEA, IGC, NAS, ND, NR, RCA, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
Evidence codes are listed at the bottom of the page.
Graph generated Thu Jan 8 13:33:51 2009.

Compare annotations to GO categories for POLA.

Entry indicates that ortholog exists for this gene.
Colored entries indicate experimental annotation.
Parentheses indicate ISS annotation only.

Category	ID	Term	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	Ecoli
Molecular Function	GO:0005488	binding	Human	Mouse	Rat	(Chicken)	Zfish	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Molecular Function	GO:0003824	catalytic activity	Human	Mouse	Rat	(Chicken)	Zfish	Fly	(Worm)	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0005623	cell	Human	Mouse	Rat	(Chicken)	Zfish	Fly	(Worm)	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0044464	cell part	Human	Mouse	Rat	(Chicken)	Zfish	Fly	(Worm)	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0031975	envelope	Human	Mouse	(Rat)	(Chicken)	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Cellular Component	GO:0032991	macromolecular complex	Human	Mouse	Rat	(Chicken)	Zfish	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0031974	membrane-enclosed lumen	Human	Mouse	(Rat)	(Chicken)	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Cellular Component	GO:0043226	organelle	Human	Mouse	Rat	(Chicken)	Zfish	Fly	(Worm)	(Dicty)	Dicot	Yeast	Pombe	X
Cellular Component	GO:0044422	organelle part	Human	Mouse	Rat	(Chicken)	Zfish	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Biological Process	GO:0065007	biological regulation	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0009987	cellular process	Human	Mouse	Rat	(Chicken)	Zfish	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X
Biological Process	GO:0032502	developmental process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0051234	establishment of localization	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0051179	localization	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0008152	metabolic process	Human	Mouse	Rat	(Chicken)	Zfish	Fly	(Worm)	(Dicty)	Dicot	Yeast	Pombe	X
Biological Process	GO:0032501	multicellular organismal process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0048519	negative regulation of biological process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0050789	regulation of biological process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0000003	reproduction	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0022414	reproductive process	Human	Mouse	Rat	Chicken	Zfish	Fly	Worm	Dicty	Dicot	Yeast	Pombe	X
Biological Process	GO:0050896	response to stimulus	Human	Mouse	(Rat)	(Chicken)	Zfish	Fly	Worm	(Dicty)	Dicot	Yeast	Pombe	X

Full set of experimental (and ISS) annotations for POLA

Category	ID	Term	DB Object	Evidence	With_From	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	POLA1	IDA		Human	PMID:16762037
Molecular Function	GO:0003682	chromatin binding	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Molecular Function	GO:0003682	chromatin binding	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0003677	DNA binding	POLA1	IDA		Human	PMID:16762037
Molecular Function	GO:0003677	DNA binding	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Molecular Function	GO:0003677	DNA binding	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0003677	DNA binding	polA1	ISS	InterPro:IPR001098	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003896	DNA primase activity	POLA1	IDA		Human	PMID:2175912
Molecular Function	GO:0003896	DNA primase activity	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Molecular Function	GO:0003896	DNA primase activity	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0003896	DNA primase activity	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IMP		Human	PMID:4084590
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:3359994
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLA1	IDA		Human	PMID:893425
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Mouse	MGI:MGI:1203906\|PMID:9584195
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Mouse	MGI:MGI:64718\|PMID:8106564
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IDA		Rat	RGD:724599\|PMID:7354082
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	IMP		Rat	RGD:1580606\|PMID:8576284
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Y47D3A.29	ISS	UniProtKB:P09884	Worm	WB:WBPaper00003297
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	polA1	ISS	InterPro:IPR001098	Dicty	dictyBase_REF:10155
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POL1	IDA		Yeast	SGD_REF:S000064604\|PMID:3907855
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POL1	IDA		Yeast	SGD_REF:S000116439\|PMID:1704371
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POL1	IDA		Yeast	SGD_REF:S000064605\|PMID:3888995
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	pol1	IGI	SGD:S000005046	Pombe	PMID:8423854
Molecular Function	GO:0003690	double-stranded DNA binding	Pola1	IDA		Rat	RGD:1580605\|PMID:7670930
Molecular Function	GO:0000166	nucleotide binding	POLA1	IDA		Human	PMID:3139084
Molecular Function	GO:0000166	nucleotide binding	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0000166	nucleotide binding	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P33993	Human	PMID:10518787
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P06750	Human	PMID:2243771
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P06400	Human	PMID:9395244
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P81460	Human	PMID:2243771
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P29558-1	Human	PMID:10869558
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:O75419	Human	PMID:10518787
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P09874	Human	PMID:9518481
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:Q14683	Human	PMID:16438930
Molecular Function	GO:0005515	protein binding	POLA1	IPI	UniProtKB:P27694	Human	PMID:1311258
Molecular Function	GO:0005515	protein binding	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Molecular Function	GO:0005515	protein binding	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Molecular Function	GO:0005515	protein binding	pol1	IPI	GeneDB_Spombe:SPBC1734.02c	Pombe	PMID:15579205
Molecular Function	GO:0005515	protein binding	pol1	IPI	GeneDB_Spombe:SPAPB1E7.02c	Pombe	PMID:15643072
Molecular Function	GO:0046982	protein heterodimerization activity	Pola1	IPI	UniProtKB:P33611	Mouse	MGI:MGI:1203906\|PMID:9584195
Molecular Function	GO:0017076	purine nucleotide binding	Pola1	IMP		Rat	RGD:1580605\|PMID:7670930
Molecular Function	GO:0019103	pyrimidine nucleotide binding	Pola1	IMP		Rat	RGD:1580605\|PMID:7670930
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POLA1	IDA		Human	PMID:2175912
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IDA		Mouse	MGI:MGI:1203906\|PMID:9584195
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	IDA		Rat	RGD:1580605\|PMID:7670930
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	POL1	IDA		Yeast	SGD_REF:S000064605\|PMID:3888995
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	pol1	IGI	SGD:S000005046	Pombe	PMID:8423854
Cellular Component	GO:0000785	chromatin	POLA1	IDA		Human	PMID:9815285
Cellular Component	GO:0000785	chromatin	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0000785	chromatin	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005737	cytoplasm	POLA1	IDA		Human	PMID:18029348
Cellular Component	GO:0005739	mitochondrion	POL1	IDA		Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005635	nuclear envelope	POLA1	IDA		Human	PMID:9518481
Cellular Component	GO:0005635	nuclear envelope	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0005635	nuclear envelope	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0016363	nuclear matrix	POLA1	IDA		Human	PMID:1903085
Cellular Component	GO:0016363	nuclear matrix	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0016363	nuclear matrix	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005730	nucleolus	POLA1	IDA		Human	PMID:9518481
Cellular Component	GO:0005730	nucleolus	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0005730	nucleolus	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005654	nucleoplasm	POLA1	IDA		Human	PMID:7045121
Cellular Component	GO:0005654	nucleoplasm	POLA1	EXP		Human	PMID:11473323
Cellular Component	GO:0005654	nucleoplasm	POLA1	EXP		Human	PMID:9822671
Cellular Component	GO:0005654	nucleoplasm	POLA1	EXP		Human	PMID:6693436
Cellular Component	GO:0005654	nucleoplasm	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0005654	nucleoplasm	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005634	nucleus	POLA1	IDA		Human	PMID:4084590
Cellular Component	GO:0005634	nucleus	POLA1	IDA		Human	PMID:16762037
Cellular Component	GO:0005634	nucleus	Pola1	IDA		Mouse	MGI:MGI:1203906\|PMID:9584195
Cellular Component	GO:0005634	nucleus	Pola1	IMP		Rat	RGD:1580616\|PMID:10969999
Cellular Component	GO:0005634	nucleus	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Cellular Component	GO:0005634	nucleus	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Cellular Component	GO:0005634	nucleus	Y47D3A.29	ISS	UniProtKB:P09884	Worm	WB:WBPaper00003297
Cellular Component	GO:0005634	nucleus	pol1	IDA		Pombe	PMID:16823372
Cellular Component	GO:0005657	replication fork	POL1	IDA		Yeast	SGD_REF:S000081149\|PMID:15773893
Cellular Component	GO:0005657	replication fork	pol1	IGI	SGD:S000005046	Pombe	PMID:8423854
Biological Process	GO:0008283	cell proliferation	POLA1	IDA		Human	PMID:3359994
Biological Process	GO:0008283	cell proliferation	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0008283	cell proliferation	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0006260	DNA replication	Pola1	IDA		Mouse	MGI:MGI:1203906\|PMID:9584195
Biological Process	GO:0006260	DNA replication	Pola1	IMP		Mouse	MGI:MGI:67849\|PMID:8125989
Biological Process	GO:0006260	DNA replication	Pola1	IDA		Mouse	MGI:MGI:64718\|PMID:8106564
Biological Process	GO:0006260	DNA replication	Pola1	IMP		Rat	RGD:1580606\|PMID:8576284
Biological Process	GO:0006260	DNA replication	Y47D3A.29	ISS	UniProtKB:P33609	Worm	WB:WBPaper00003297
Biological Process	GO:0006260	DNA replication	polA1	ISS	InterPro:IPR001098	Dicty	dictyBase_REF:10155
Biological Process	GO:0006260	DNA replication	POL1	IMP		Yeast	SGD_REF:S000056892\|PMID:2651896
Biological Process	GO:0000076	DNA replication checkpoint	pol1	IMP		Pombe	PMID:8537450
Biological Process	GO:0006270	DNA replication initiation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006270	DNA replication initiation	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0006270	DNA replication initiation	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0006270	DNA replication initiation	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Biological Process	GO:0006270	DNA replication initiation	POL1	IC	GO:0005658	Yeast	SGD_REF:S000064605\|PMID:3888995
Biological Process	GO:0006270	DNA replication initiation	pol1	IMP		Pombe	PMID:8537450
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	pol1	IGI	SGD:S000005046	Pombe	PMID:8537450
Biological Process	GO:0000731	DNA synthesis during DNA repair	POLA1	IDA		Human	PMID:3335506
Biological Process	GO:0000731	DNA synthesis during DNA repair	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0000731	DNA synthesis during DNA repair	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0000731	DNA synthesis during DNA repair	polA1	ISS	SGD:S000005046	Dicty	dictyBase_REF:10155
Biological Process	GO:0000731	DNA synthesis during DNA repair	POL1	IMP		Yeast	SGD_REF:S000056892\|PMID:2651896
Biological Process	GO:0000731	DNA synthesis during DNA repair	POL1	IMP		Yeast	SGD_REF:S000056091\|PMID:10025407
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	POLA1	IMP		Human	PMID:11470886
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	Y47D3A.29	IMP	WB:WBRNAi00009341\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	Y47D3A.29	IMP	WB:WBRNAi00009342\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	Y47D3A.29	IMP	WB:WBRNAi00026719\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	Y47D3A.29	IMP	WB:WBRNAi00026720\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	Y47D3A.29	IMP	WB:WBRNAi00056755\|WB:WBPhenotype:0000050	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0000734	gene conversion at mating-type locus, DNA repair synthesis	pol1	IMP		Pombe	PMID:8423854
Biological Process	GO:0006273	lagging strand elongation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006273	lagging strand elongation	POLA1	IDA		Human	PMID:7910375
Biological Process	GO:0006273	lagging strand elongation	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0006273	lagging strand elongation	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0006273	lagging strand elongation	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Biological Process	GO:0006273	lagging strand elongation	POL1	IC	GO:0005658	Yeast	SGD_REF:S000064605\|PMID:3888995
Biological Process	GO:0006272	leading strand elongation	POLA1	IDA		Human	PMID:2175912
Biological Process	GO:0006272	leading strand elongation	POLA1	IDA		Human	PMID:7910375
Biological Process	GO:0006272	leading strand elongation	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0006272	leading strand elongation	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0006272	leading strand elongation	polA1	ISS	UniProt:P09884	Dicty	dictyBase_REF:10155
Biological Process	GO:0006279	premeiotic DNA synthesis	POL1	IMP		Yeast	SGD_REF:S000056892\|PMID:2651896
Biological Process	GO:0035046	pronuclear migration	Y47D3A.29	IMP	WB:WBRNAi00056755\|WB:WBPhenotype:0001152	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0006278	RNA-dependent DNA replication	POL1	IDA		Yeast	SGD_REF:S000122326\|PMID:17429354
Biological Process	GO:0000084	S phase of mitotic cell cycle	POLA1	IDA		Human	PMID:16762037
Biological Process	GO:0000084	S phase of mitotic cell cycle	Pola1	ISS	UniProtKB:P09884	Rat	RGD:1600115
Biological Process	GO:0000084	S phase of mitotic cell cycle	Q59J86	ISS	UniProtKB:P09884	Chicken	UniProtKB:Q59J86
Biological Process	GO:0000723	telomere maintenance	pol1	IMP		Pombe	PMID:12697806

Gene Ontology Evidence Code Abbreviations:

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IEP Inferred from expression pattern

IGC Inferred from genomic context

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

NAS Non-traceable Author Statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

NR Not recorded (appears in some legacy annotations)