Annotation related questions (e.g. evidence codes, ID mapping...).

Where can I find software to allow me to make or edit GO annotations?

GO annotations can be made and edited using various database-specific tools. Please contact the relevant database to find out how their GO annotation is done. The GMOD online tool, Canto, supports functional gene annotation by community researchers as well as by professional curators.

Sometimes the number of GO annotations changes significantly over a short period of time. Why?

Most annotations in association files are electronically inferred (IEA). As with all types of annotations, IEAs change over time, with an overall increasing trend. However, in the specific case of IEAs, significant fluctuations in numbers may sometimes be observed over a short period of time. Nearly always, these are not due to bugs, but rather to the following reasons and/or to a combination thereof: