The Gene Ontology Consortium is moving towards a more expressive way of describing the function of gene products that allows annotations to be connected together to give a complete function of what each gene does in the context of a larger biological process. The new model is called LEGO, for "Logical Extension of the Gene Ontology".
For example, with the current datamodel and Gene Association Files, it's possible to make two statements:
- TEM1 enables GTPase activity
- BFA1 enables GTPase inhibitor activity