A new article from GO Consortium members was published this week in the journal Autophagy.
Autophagy is a fundamental process used to recycle cellular components, respond to cellular stresses and remove foreign material from cells. Disruption of autophagy can lead to neurodegeneration, cardiac disease and cancer.
The paper describes the work of GO Consortium members from University College London, EMBL-EBI, Swiss Institute of Bioinformatics and The Jackson Laboratory to expand and refine the Gene Ontology terms that describe autophagy and the subsequent effort to improve the annotation of proteins involved in autophagy. This autophagy-focused annotation project has led to a more complete representation of autophagy in the GO database, enabling better interpretation of autophagy-related disease datasets, e.g. Parkinson's disease, as well as providing additional insights into the functional roles of autophagy-related protein interaction networks.
Read the article here: http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1415189
Figure taken from Denny et al. Autophagy 2018. doi:10.1080/15548627.2017.1415189