format-version: 1.2 date: 25:09:2009 11:40 auto-generated-by: OBO-Edit 2.1-beta1 saved-by: jane synonymtypedef: systematic_synonym "Systematic synonym" EXACT subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" remark: cvs version: $Revision: 1.7 $ [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai] subset: goslim_candida subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:449273 "Mitotic Telophase /Cytokinesis" xref: Reactome:470393 "Mitotic Telophase /Cytokinesis" xref: Reactome:488068 "Mitotic Telophase /Cytokinesis" xref: Reactome:508035 "Mitotic Telophase /Cytokinesis" xref: Reactome:517891 "Mitotic Telophase /Cytokinesis" xref: Reactome:526715 "Mitotic Telophase /Cytokinesis" xref: Reactome:531490 "Mitotic Telophase /Cytokinesis" xref: Reactome:542630 "Mitotic Telophase /Cytokinesis" xref: Reactome:547945 "Mitotic Telophase /Cytokinesis" xref: Reactome:552520 "Mitotic Telophase /Cytokinesis" xref: Reactome:558142 "Mitotic Telophase /Cytokinesis" xref: Reactome:586024 "Mitotic Telophase /Cytokinesis" xref: Reactome:592880 "Mitotic Telophase /Cytokinesis" xref: Reactome:68884 "Mitotic Telophase /Cytokinesis" xref: Wikipedia:Cytokinesis is_a: GO:0008150 ! biological_process [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:448487 "Metabolism of carbohydrates" xref: Reactome:469617 "Metabolism of carbohydrates" xref: Reactome:487336 "Metabolism of carbohydrates" xref: Reactome:507287 "Metabolism of carbohydrates" xref: Reactome:517301 "Metabolism of carbohydrates" xref: Reactome:526186 "Metabolism of carbohydrates" xref: Reactome:531076 "Metabolism of carbohydrates" xref: Reactome:536449 "Metabolism of carbohydrates" xref: Reactome:542153 "Metabolism of carbohydrates" xref: Reactome:547511 "Metabolism of carbohydrates" xref: Reactome:552109 "Metabolism of carbohydrates" xref: Reactome:557702 "Metabolism of carbohydrates" xref: Reactome:568311 "Metabolism of carbohydrates" xref: Reactome:581513 "Metabolism of carbohydrates" xref: Reactome:585745 "Metabolism of carbohydrates" xref: Reactome:592407 "Metabolism of carbohydrates" xref: Reactome:595291 "Metabolism of carbohydrates" xref: Reactome:597267 "Metabolism of carbohydrates" xref: Reactome:598076 "Metabolism of carbohydrates" xref: Reactome:599604 "Metabolism of carbohydrates" xref: Reactome:600550 "Metabolism of carbohydrates" xref: Reactome:602409 "Metabolism of carbohydrates" xref: Reactome:71387 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "DNA metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006260 name: DNA replication namespace: biological_process def: "The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "DNA biosynthesis" RELATED [] synonym: "DNA biosynthetic process" RELATED [] synonym: "DNA synthesis" RELATED [] xref: Reactome:176101 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:176116 "Recruitment and activation of Chk1" xref: Reactome:176175 "Stalling of DNA replication fork and RPA binding" xref: Reactome:176187 "Activation of ATR in response to replication stress" xref: Reactome:176250 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:176298 "Activation of claspin" xref: Reactome:176318 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:429125 "Activation of claspin" xref: Reactome:433202 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:442012 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:446069 "Recruitment and activation of Chk1" xref: Reactome:446123 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:446153 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:447074 "Stalling of DNA replication fork and RPA binding" xref: Reactome:448696 "Activation of ATR in response to replication stress" xref: Reactome:463715 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:467450 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:467477 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:468344 "Stalling of DNA replication fork and RPA binding" xref: Reactome:470298 "Activation of ATR in response to replication stress" xref: Reactome:472164 "Activation of claspin" xref: Reactome:475516 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:482185 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:485413 "Recruitment and activation of Chk1" xref: Reactome:485440 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:485461 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:486163 "Stalling of DNA replication fork and RPA binding" xref: Reactome:487512 "Activation of ATR in response to replication stress" xref: Reactome:490390 "Activation of claspin" xref: Reactome:502397 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:505179 "Recruitment and activation of Chk1" xref: Reactome:507473 "Activation of ATR in response to replication stress" xref: Reactome:514771 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:516172 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:517816 "Activation of ATR in response to replication stress" xref: Reactome:525168 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:526692 "Activation of ATR in response to replication stress" xref: Reactome:531467 "Activation of ATR in response to replication stress" xref: Reactome:536852 "Activation of ATR in response to replication stress" xref: Reactome:541523 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:542605 "Activation of ATR in response to replication stress" xref: Reactome:546964 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:547923 "Activation of ATR in response to replication stress" xref: Wikipedia:DNA_replication is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_pir subset: goslim_pombe subset: gosubset_prok xref: Reactome:448579 "DNA Repair" xref: Reactome:449225 "DNA Damage Reversal" xref: Reactome:469708 "DNA Repair" xref: Reactome:470344 "DNA Damage Reversal" xref: Reactome:487420 "DNA Repair" xref: Reactome:488024 "DNA Damage Reversal" xref: Reactome:507375 "DNA Repair" xref: Reactome:507985 "DNA Damage Reversal" xref: Reactome:517374 "DNA Repair" xref: Reactome:526250 "DNA Repair" xref: Reactome:531127 "DNA Repair" xref: Reactome:536499 "DNA Repair" xref: Reactome:542209 "DNA Repair" xref: Reactome:542599 "DNA Damage Reversal" xref: Reactome:547563 "DNA Repair" xref: Reactome:552173 "DNA Repair" xref: Reactome:557757 "DNA Repair" xref: Reactome:558121 "DNA Damage Reversal" xref: Reactome:568370 "DNA Repair" xref: Reactome:568747 "DNA Damage Reversal" xref: Reactome:581572 "DNA Repair" xref: Reactome:581951 "DNA Damage Reversal" xref: Reactome:585783 "DNA Repair" xref: Reactome:592468 "DNA Repair" xref: Reactome:595411 "DNA Repair" xref: Reactome:597351 "DNA Repair" xref: Reactome:598160 "DNA Repair" xref: Reactome:599712 "DNA Repair" xref: Reactome:600616 "DNA Repair" xref: Reactome:600694 "DNA Damage Reversal" xref: Reactome:602518 "DNA Repair" xref: Reactome:602608 "DNA Damage Reversal" xref: Reactome:73894 "DNA Repair" xref: Reactome:73942 "DNA Damage Reversal" xref: Wikipedia:DNA_repair is_a: GO:0006950 ! response to stress is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006350 name: transcription namespace: biological_process def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:448636 "Transcription" xref: Reactome:469764 "Transcription" xref: Reactome:487521 "Transcription" xref: Reactome:507482 "Transcription" xref: Reactome:517466 "Transcription" xref: Reactome:526339 "Transcription" xref: Reactome:531172 "Transcription" xref: Reactome:536547 "Transcription" xref: Reactome:542268 "Transcription" xref: Reactome:547614 "Transcription" xref: Reactome:552218 "Transcription" xref: Reactome:557808 "Transcription" xref: Reactome:568425 "Transcription" xref: Reactome:581627 "Transcription" xref: Reactome:585958 "Transcription" xref: Reactome:592524 "Transcription" xref: Reactome:595359 "Transcription" xref: Reactome:74159 "Transcription" xref: Wikipedia:Transcription_(genetics) relationship: part_of GO:0008150 ! biological_process is_a: GO:0008150 ! biological_process [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "tRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:448800 "Translation" xref: Reactome:469916 "Translation" xref: Reactome:487622 "Translation" xref: Reactome:507577 "Translation" xref: Reactome:517550 "Translation" xref: Reactome:526417 "Translation" xref: Reactome:531240 "Translation" xref: Reactome:536611 "Translation" xref: Reactome:542335 "Translation" xref: Reactome:547676 "Translation" xref: Reactome:552260 "Translation" xref: Reactome:557879 "Translation" xref: Reactome:568477 "Translation" xref: Reactome:581688 "Translation" xref: Reactome:585834 "Translation" xref: Reactome:592595 "Translation" xref: Reactome:595406 "Translation" xref: Reactome:597395 "Translation" xref: Reactome:598177 "Translation" xref: Reactome:599776 "Translation" xref: Reactome:72766 "Translation" xref: Wikipedia:Translation_(genetics) relationship: part_of GO:0008150 ! biological_process is_a: GO:0008150 ! biological_process [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:389960 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:389967 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:390466 "Chaperonin-mediated protein folding" xref: Reactome:392033 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding" xref: Reactome:448640 "Chaperonin-mediated protein folding" xref: Reactome:448770 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:469768 "Chaperonin-mediated protein folding" xref: Reactome:469885 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:487587 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:487589 "Chaperonin-mediated protein folding" xref: Reactome:507422 "Chaperonin-mediated protein folding" xref: Reactome:507545 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:517425 "Chaperonin-mediated protein folding" xref: Reactome:517525 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:526299 "Chaperonin-mediated protein folding" xref: Reactome:526394 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:531205 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:531207 "Chaperonin-mediated protein folding" xref: Reactome:536535 "Chaperonin-mediated protein folding" xref: Reactome:536580 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:542256 "Chaperonin-mediated protein folding" xref: Reactome:542306 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:547600 "Chaperonin-mediated protein folding" xref: Reactome:547647 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:552207 "Chaperonin-mediated protein folding" xref: Reactome:552239 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:557798 "Chaperonin-mediated protein folding" xref: Reactome:557852 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:568411 "Chaperonin-mediated protein folding" xref: Reactome:568446 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:581613 "Chaperonin-mediated protein folding" xref: Reactome:581659 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:585812 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:585814 "Chaperonin-mediated protein folding" xref: Reactome:592510 "Chaperonin-mediated protein folding" xref: Reactome:592570 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:595349 "Chaperonin-mediated protein folding" xref: Reactome:595388 "Formation of tubulin folding intermediates by CCT/TriC" xref: Wikipedia:Protein_folding is_a: GO:0008150 ! biological_process [Term] id: GO:0006461 name: protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] subset: goslim_pombe subset: gosubset_prok synonym: "chaperone activity" RELATED [] synonym: "protein complex biosynthesis" EXACT [] synonym: "protein complex formation" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006486 name: protein amino acid glycosylation namespace: biological_process def: "The addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [http://cancerweb.ncl.ac.uk/] subset: goslim_pombe subset: gosubset_prok relationship: part_of GO:0008150 ! biological_process is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] subset: goslim_pombe subset: gosubset_prok synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006810 ! transport relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "lipid metabolism" EXACT [] xref: Reactome:448458 "Metabolism of lipids and lipoproteins" xref: Reactome:469588 "Metabolism of lipids and lipoproteins" xref: Reactome:487307 "Metabolism of lipids and lipoproteins" xref: Reactome:507258 "Metabolism of lipids and lipoproteins" xref: Reactome:517280 "Metabolism of lipids and lipoproteins" xref: Reactome:526158 "Metabolism of lipids and lipoproteins" xref: Reactome:531055 "Metabolism of lipids and lipoproteins" xref: Reactome:536437 "Metabolism of lipids and lipoproteins" xref: Reactome:542134 "Metabolism of lipids and lipoproteins" xref: Reactome:547525 "Metabolism of lipids and lipoproteins" xref: Reactome:552094 "Metabolism of lipids and lipoproteins" xref: Reactome:557672 "Metabolism of lipids and lipoproteins" xref: Reactome:568290 "Metabolism of lipids and lipoproteins" xref: Reactome:581492 "Metabolism of lipids and lipoproteins" xref: Reactome:585774 "Metabolism of lipids and lipoproteins" xref: Reactome:592389 "Metabolism of lipids and lipoproteins" xref: Reactome:595297 "Metabolism of lipids and lipoproteins" xref: Reactome:597258 "Metabolism of lipids and lipoproteins" xref: Reactome:598099 "Metabolism of lipids and lipoproteins" xref: Reactome:599584 "Metabolism of lipids and lipoproteins" xref: Reactome:600579 "Metabolism of lipids and lipoproteins" xref: Reactome:602390 "Metabolism of lipids and lipoproteins" xref: Reactome:73923 "Metabolism of lipids and lipoproteins" xref: Wikipedia:Lipid_metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "vitamin metabolism" EXACT [] xref: Reactome:196854 "Metabolism of vitamins and cofactors" xref: Reactome:448501 "Metabolism of vitamins and cofactors" xref: Reactome:469631 "Metabolism of vitamins and cofactors" xref: Reactome:487350 "Metabolism of vitamins and cofactors" xref: Reactome:507301 "Metabolism of vitamins and cofactors" xref: Reactome:517315 "Metabolism of vitamins and cofactors" xref: Reactome:526200 "Metabolism of vitamins and cofactors" xref: Reactome:531086 "Metabolism of vitamins and cofactors" xref: Reactome:536459 "Metabolism of vitamins and cofactors" xref: Reactome:542163 "Metabolism of vitamins and cofactors" xref: Reactome:547521 "Metabolism of vitamins and cofactors" xref: Reactome:552114 "Metabolism of vitamins and cofactors" xref: Reactome:557706 "Metabolism of vitamins and cofactors" xref: Reactome:568321 "Metabolism of vitamins and cofactors" xref: Reactome:581523 "Metabolism of vitamins and cofactors" xref: Reactome:585808 "Metabolism of vitamins and cofactors" xref: Reactome:592410 "Metabolism of vitamins and cofactors" xref: Reactome:595340 "Metabolism of vitamins and cofactors" xref: Reactome:597308 "Metabolism of vitamins and cofactors" xref: Reactome:598109 "Metabolism of vitamins and cofactors" xref: Reactome:599609 "Metabolism of vitamins and cofactors" xref: Reactome:600553 "Metabolism of vitamins and cofactors" xref: Reactome:602413 "Metabolism of vitamins and cofactors" is_a: GO:0008150 ! biological_process [Term] id: GO:0006796 name: phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] subset: goslim_pombe subset: gosubset_prok synonym: "phosphate metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006810 name: transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] relationship: part_of GO:0008150 ! biological_process is_a: GO:0006810 ! transport [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [GOC:curators] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007033 name: vacuole organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vacuolar assembly" EXACT [] synonym: "vacuole organisation" EXACT [GOC:curators] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0008150 ! biological_process [Term] id: GO:0007126 name: meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [GOC:dph, GOC:mah, PMID:9334324] subset: goslim_pombe subset: goslim_yeast xref: Wikipedia:Meiosis is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "cell adhesion molecule activity" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0008150 ! biological_process [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] relationship: part_of GO:0008150 ! biological_process is_a: GO:0008150 ! biological_process [Term] id: GO:0007165 name: signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "signaling" EXACT [] synonym: "signaling cascade" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling cascade" EXACT [] xref: Reactome:212718 "EGFR interacts with phospholipase C-gamma" xref: Reactome:448734 "EGFR interacts with phospholipase C-gamma" xref: Reactome:469856 "EGFR interacts with phospholipase C-gamma" xref: Reactome:487553 "EGFR interacts with phospholipase C-gamma" xref: Reactome:507509 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_pombe synonym: "control of mitotic cell cycle progression" EXACT [] synonym: "mitotic cell cycle control" EXACT [] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "biological process" EXACT [] synonym: "biological process unknown" NARROW [] synonym: "physiological process" EXACT [] xref: Wikipedia:Biological_process [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "RNA metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0016071 name: mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "mRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] relationship: part_of GO:0008150 ! biological_process is_a: GO:0006810 ! transport [Term] id: GO:0016568 name: chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure." [GOC:mah] subset: goslim_pombe is_a: GO:0051276 ! chromosome organization [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] subset: goslim_candida subset: goslim_pombe subset: gosubset_prok synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0030437 name: ascospore formation namespace: biological_process alt_id: GO:0007151 def: "The process whereby cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:mah, PMID:16339736] subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0032569 name: gene-specific transcription from RNA polymerase II promoter namespace: biological_process def: "The specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. In addition to RNA polymerase II and the general transcription factors, specific transcription requires one or more specific factors that bind to specific DNA sequences or interact with the general transcription machinery." [GOC:mah] subset: goslim_pombe synonym: "specific transcription from RNA polymerase II promoter" EXACT [GOC:mah] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0006350 ! transcription relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_pombe subset: gosubset_prok synonym: "cellular nitrogen compound metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:ma] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal chaperone activity" RELATED [] synonym: "ribosome biogenesis and assembly" EXACT [] xref: Wikipedia:Ribosome_biogenesis is_a: GO:0008150 ! biological_process [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cofactor metabolism" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process def: "The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute." [GOC:jid] subset: goslim_pombe xref: Reactome:382551 "Transmembrane transport of small molecules" xref: Reactome:382556 "ABC-family proteins mediated transport" xref: Reactome:448617 "ABC-family proteins mediated transport" xref: Reactome:448618 "Transmembrane transport of small molecules" xref: Reactome:469743 "ABC-family proteins mediated transport" xref: Reactome:469744 "Transmembrane transport of small molecules" xref: Reactome:487452 "ABC-family proteins mediated transport" xref: Reactome:487453 "Transmembrane transport of small molecules" xref: Reactome:507409 "ABC-family proteins mediated transport" xref: Reactome:507410 "Transmembrane transport of small molecules" xref: Reactome:517410 "ABC-family proteins mediated transport" xref: Reactome:517411 "Transmembrane transport of small molecules" xref: Reactome:526284 "ABC-family proteins mediated transport" xref: Reactome:526285 "Transmembrane transport of small molecules" xref: Reactome:531148 "ABC-family proteins mediated transport" xref: Reactome:531149 "Transmembrane transport of small molecules" xref: Reactome:536519 "ABC-family proteins mediated transport" xref: Reactome:536520 "Transmembrane transport of small molecules" xref: Reactome:542237 "ABC-family proteins mediated transport" xref: Reactome:542238 "Transmembrane transport of small molecules" xref: Reactome:547954 "Transmembrane transport of small molecules" xref: Reactome:552197 "ABC-family proteins mediated transport" xref: Reactome:552198 "Transmembrane transport of small molecules" xref: Reactome:557783 "ABC-family proteins mediated transport" xref: Reactome:557784 "Transmembrane transport of small molecules" xref: Reactome:568396 "ABC-family proteins mediated transport" xref: Reactome:568397 "Transmembrane transport of small molecules" xref: Reactome:581598 "ABC-family proteins mediated transport" xref: Reactome:581599 "Transmembrane transport of small molecules" xref: Reactome:585791 "ABC-family proteins mediated transport" xref: Reactome:585792 "Transmembrane transport of small molecules" xref: Reactome:592494 "ABC-family proteins mediated transport" xref: Reactome:592495 "Transmembrane transport of small molecules" xref: Reactome:597317 "ABC-family proteins mediated transport" xref: Reactome:597318 "Transmembrane transport of small molecules" xref: Reactome:598116 "ABC-family proteins mediated transport" xref: Reactome:598117 "Transmembrane transport of small molecules" xref: Reactome:599664 "ABC-family proteins mediated transport" xref: Reactome:599665 "Transmembrane transport of small molecules" xref: Reactome:600589 "ABC-family proteins mediated transport" xref: Reactome:600590 "Transmembrane transport of small molecules" xref: Reactome:602478 "ABC-family proteins mediated transport" xref: Reactome:602479 "Transmembrane transport of small molecules" relationship: part_of GO:0008150 ! biological_process is_a: GO:0006810 ! transport [Term] id: GO:0055086 name: nucleobase, nucleoside and nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nucleobases, nucleosides and nucleotides." [GOC:vw] subset: goslim_pombe subset: gosubset_prok synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:15869 "Metablism of nucleotides" xref: Reactome:448478 "Metablism of nucleotides" xref: Reactome:469608 "Metablism of nucleotides" xref: Reactome:487327 "Metablism of nucleotides" xref: Reactome:507278 "Metablism of nucleotides" xref: Reactome:517298 "Metablism of nucleotides" xref: Reactome:526177 "Metablism of nucleotides" xref: Reactome:531067 "Metablism of nucleotides" xref: Reactome:536446 "Metablism of nucleotides" xref: Reactome:542144 "Metablism of nucleotides" xref: Reactome:547508 "Metablism of nucleotides" xref: Reactome:552100 "Metablism of nucleotides" xref: Reactome:557684 "Metablism of nucleotides" xref: Reactome:568302 "Metablism of nucleotides" xref: Reactome:581504 "Metablism of nucleotides" xref: Reactome:585751 "Metablism of nucleotides" xref: Reactome:592420 "Metablism of nucleotides" xref: Reactome:595288 "Metablism of nucleotides" xref: Reactome:597277 "Metablism of nucleotides" xref: Reactome:598083 "Metablism of nucleotides" xref: Reactome:599589 "Metablism of nucleotides" xref: Reactome:600547 "Metablism of nucleotides" xref: Reactome:602400 "Metablism of nucleotides" is_a: GO:0008150 ! biological_process [Term] id: GO:0070647 name: protein modification by small protein conjugation or removal namespace: biological_process def: "A protein modification process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] subset: goslim_pombe is_a: GO:0008150 ! biological_process [Term] id: GO:0070882 name: cell wall organization or biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_pombe subset: gosubset_prok is_a: GO:0008150 ! biological_process [Typedef] id: has_part name: has_part namespace: gene_ontology is_transitive: true [Typedef] id: negatively_regulates name: negatively_regulates namespace: gene_ontology is_a: regulates ! regulates [Typedef] id: part_of name: part_of namespace: gene_ontology xref: OBO_REL:part_of is_transitive: true [Typedef] id: positively_regulates name: positively_regulates namespace: gene_ontology is_a: regulates ! regulates [Typedef] id: regulates name: regulates namespace: gene_ontology