format-version: 1.2
date: 15:08:2011 17:04
auto-generated-by: OBO-Edit 2.0
ontology: go
saved-by: kchris
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
subsetdef: high_level_annotation_qc "High-level terms not to be used for direct annotation"
subsetdef: unvetted "unvetted"
remark: cvs version: $Revision: 1.101 $

[Term]
id: GO:0000003
name: reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "reproductive physiological process" EXACT []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000128
name: flocculation
namespace: biological_process
def: "The non-sexual aggregation of single-celled organisms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flocculation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030427 ! site of polarized growth
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000166
name: nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases." [PMID:10465791]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subset: goslim_pir
synonym: "exosome (ribonucleasease complex)" EXACT []
synonym: "exosome multienzyme ribonuclease complex" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000267
name: cell fraction
namespace: cellular_component
def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
subset: goslim_pir
synonym: "CDK holoenzyme" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
subset: goslim_pir
synonym: "TREX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000441
name: SSL2-core TFIIH complex
namespace: cellular_component
def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0000502
name: proteasome complex
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb]
subset: goslim_pir
synonym: "26S proteasome" NARROW []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
alt_id: GO:0005699
def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Kinetochore
is_a: GO:0043234 ! protein complex
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
alt_id: GO:0005718
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Nucleosome
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
alt_id: GO:0005676
alt_id: GO:0008620
def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
subset: goslim_pir
synonym: "13S condensin complex" NARROW []
synonym: "SMC complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: goslim_pir
subset: gosubset_prok
synonym: "ORC" EXACT []
synonym: "origin of replication recognition complex" EXACT []
xref: Wikipedia:Origin_recognition_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971]
subset: goslim_pir
xref: Wikipedia:Radial_spoke
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0042995 ! cell projection
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subset: goslim_pir
synonym: "interferon production" NARROW [GOC:mah, GOC:add]
synonym: "interleukin production" NARROW [GOC:mah, GOC:add]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001871
name: pattern binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]
comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead.
subset: goslim_pir
subset: gosubset_prok
synonym: "pattern recognition activity" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0001906
name: cell killing
namespace: biological_process
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "necrosis" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
subset: goslim_generic
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []
synonym: "molecular function unknown" NARROW []

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: goslim_plant
synonym: "lamin/chromatin binding" BROAD []
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003823
name: antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544]
subset: goslim_pir
synonym: "B cell receptor activity" RELATED []
synonym: "antibody" RELATED []
synonym: "immunoglobulin" RELATED []
synonym: "opsonin activity" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "enzyme activity" EXACT [GOC:tb, GOC:dph]
xref: Wikipedia:Enzyme
relationship: part_of GO:0008152 ! metabolic process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0004133
name: glycogen debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0006112 ! energy reserve metabolic process
relationship: part_of GO:0044237 ! cellular metabolic process
relationship: part_of GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_100335 ! RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum
xref: Reactome:REACT_101111 ! Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae
xref: Reactome:REACT_101247 ! Formation of open bubble structure in DNA by helicases, Bos taurus
xref: Reactome:REACT_101622 ! MCM8 mediated fork unwinding, Danio rerio
xref: Reactome:REACT_101644 ! Formation of open bubble structure in DNA by helicases, Oryza sativa
xref: Reactome:REACT_101823 ! MCM2-7 mediated fork unwinding, Plasmodium falciparum
xref: Reactome:REACT_101994 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis
xref: Reactome:REACT_102116 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Bos taurus
xref: Reactome:REACT_102121 ! Addition of the third nucleotide on the nascent transcript, Rattus norvegicus
xref: Reactome:REACT_102441 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus
xref: Reactome:REACT_102560 ! MCM2-7 mediated fork unwinding, Oryza sativa
xref: Reactome:REACT_1033 ! Formation of open bubble structure in DNA by helicases, Homo sapiens
xref: Reactome:REACT_103861 ! MCM8 mediated fork unwinding, Bos taurus
xref: Reactome:REACT_103897 ! MCM8 mediated fork unwinding, Mus musculus
xref: Reactome:REACT_103959 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus
xref: Reactome:REACT_104221 ! MCM2-7 mediated fork unwinding, Rattus norvegicus
xref: Reactome:REACT_105950 ! MCM2-7 mediated fork unwinding, Xenopus tropicalis
xref: Reactome:REACT_106346 ! Formation of open bubble structure in DNA by helicases, Taeniopygia guttata
xref: Reactome:REACT_107072 ! Formation of open bubble structure in DNA by helicases, Mus musculus
xref: Reactome:REACT_107495 ! RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata
xref: Reactome:REACT_108159 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum
xref: Reactome:REACT_108648 ! Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana
xref: Reactome:REACT_108654 ! MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe
xref: Reactome:REACT_109035 ! RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe
xref: Reactome:REACT_109161 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana
xref: Reactome:REACT_110588 ! MCM8 mediated fork unwinding, Xenopus tropicalis
xref: Reactome:REACT_110827 ! Formation of open bubble structure in DNA by helicases, Danio rerio
xref: Reactome:REACT_110838 ! Addition of the third nucleotide on the nascent transcript, Bos taurus
xref: Reactome:REACT_110845 ! Cap-bound mRNA is activated by helicases, Mus musculus
xref: Reactome:REACT_1521 ! Cap-bound mRNA is activated by helicases, Homo sapiens
xref: Reactome:REACT_1817 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens
xref: Reactome:REACT_1844 ! RNA Polymerase II Promoter Opening: First Transition, Homo sapiens
xref: Reactome:REACT_28131 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster
xref: Reactome:REACT_28343 ! MCM2-7 mediated fork unwinding, Danio rerio
xref: Reactome:REACT_28810 ! Addition of the third nucleotide on the nascent transcript, Oryza sativa
xref: Reactome:REACT_28880 ! MCM2-7 mediated fork unwinding, Drosophila melanogaster
xref: Reactome:REACT_29155 ! Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster
xref: Reactome:REACT_29217 ! Formation of open bubble structure in DNA by helicases, Xenopus tropicalis
xref: Reactome:REACT_29818 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa
xref: Reactome:REACT_29850 ! RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae
xref: Reactome:REACT_30013 ! MCM8 mediated fork unwinding, Rattus norvegicus
xref: Reactome:REACT_30989 ! MCM8 mediated fork unwinding, Arabidopsis thaliana
xref: Reactome:REACT_31034 ! Cap-bound mRNA is activated by helicases, Danio rerio
xref: Reactome:REACT_31090 ! MCM2-7 mediated fork unwinding, Gallus gallus
xref: Reactome:REACT_32533 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans
xref: Reactome:REACT_33205 ! MCM8 mediated fork unwinding, Canis familiaris
xref: Reactome:REACT_34016 ! Formation of open bubble structure in DNA by helicases, Rattus norvegicus
xref: Reactome:REACT_34089 ! MCM2-7 mediated fork unwinding, Dictyostelium discoideum
xref: Reactome:REACT_34560 ! MCM8 mediated fork unwinding, Sus scrofa
xref: Reactome:REACT_40 ! Addition of the third nucleotide on the nascent transcript, Homo sapiens
xref: Reactome:REACT_6134 ! HIV-1 Promoter Opening: First Transition, Homo sapiens
xref: Reactome:REACT_6184 ! Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens
xref: Reactome:REACT_6325 ! Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens
xref: Reactome:REACT_6758 ! Xenopus Mcm8 mediated fork unwinding, Xenopus laevis
xref: Reactome:REACT_6768 ! MCM8 mediated fork unwinding, Homo sapiens
xref: Reactome:REACT_6853 ! Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae
xref: Reactome:REACT_6922 ! MCM2-7 mediated fork unwinding, Homo sapiens
xref: Reactome:REACT_78086 ! RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus
xref: Reactome:REACT_78462 ! Formation of open bubble structure in DNA by helicases, Drosophila melanogaster
xref: Reactome:REACT_78667 ! MCM2-7 mediated fork unwinding, Canis familiaris
xref: Reactome:REACT_78771 ! MCM8 mediated fork unwinding, Dictyostelium discoideum
xref: Reactome:REACT_79401 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe
xref: Reactome:REACT_79759 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus
xref: Reactome:REACT_80107 ! RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana
xref: Reactome:REACT_80325 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio
xref: Reactome:REACT_80500 ! MCM8 mediated fork unwinding, Gallus gallus
xref: Reactome:REACT_80532 ! Addition of the third nucleotide on the nascent transcript, Gallus gallus
xref: Reactome:REACT_80605 ! Addition of the third nucleotide on the nascent transcript, Mus musculus
xref: Reactome:REACT_81126 ! Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe
xref: Reactome:REACT_81335 ! RNA Polymerase II Promoter Opening: First Transition, Gallus gallus
xref: Reactome:REACT_81427 ! MCM8 mediated fork unwinding, Taeniopygia guttata
xref: Reactome:REACT_81441 ! MCM8 mediated fork unwinding, Oryza sativa
xref: Reactome:REACT_81682 ! Formation of open bubble structure in DNA by helicases, Canis familiaris
xref: Reactome:REACT_82776 ! RNA Polymerase II Promoter Opening: First Transition, Danio rerio
xref: Reactome:REACT_83794 ! Formation of open bubble structure in DNA by helicases, Gallus gallus
xref: Reactome:REACT_84565 ! Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe
xref: Reactome:REACT_84574 ! Cap-bound mRNA is activated by helicases, Canis familiaris
xref: Reactome:REACT_84809 ! MCM2-7 mediated fork unwinding, Mus musculus
xref: Reactome:REACT_84907 ! MCM2-7 mediated fork unwinding, Taeniopygia guttata
xref: Reactome:REACT_85111 ! Cap-bound mRNA is activated by helicases, Drosophila melanogaster
xref: Reactome:REACT_85172 ! MCM2-7 mediated fork unwinding, Arabidopsis thaliana
xref: Reactome:REACT_86220 ! MCM2-7 mediated fork unwinding, Caenorhabditis elegans
xref: Reactome:REACT_88362 ! Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans
xref: Reactome:REACT_88953 ! Addition of the third nucleotide on the nascent transcript, Canis familiaris
xref: Reactome:REACT_89000 ! MCM2-7 mediated fork unwinding, Bos taurus
xref: Reactome:REACT_89030 ! Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae
xref: Reactome:REACT_89363 ! Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis
xref: Reactome:REACT_89694 ! RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster
xref: Reactome:REACT_91596 ! RNA Polymerase II Promoter Opening: First Transition, Canis familiaris
xref: Reactome:REACT_91692 ! RNA Polymerase II Promoter Opening: First Transition, Bos taurus
xref: Reactome:REACT_91822 ! MCM8 mediated fork unwinding, Plasmodium falciparum
xref: Reactome:REACT_93046 ! Cap-bound mRNA is activated by helicases, Rattus norvegicus
xref: Reactome:REACT_93391 ! RNA Polymerase II Promoter Opening: First Transition, Oryza sativa
xref: Reactome:REACT_93711 ! RNA Polymerase II Promoter Opening: First Transition, Mus musculus
xref: Reactome:REACT_94645 ! RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis
xref: Reactome:REACT_94679 ! RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans
xref: Reactome:REACT_95942 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae
xref: Reactome:REACT_95993 ! Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana
xref: Reactome:REACT_98273 ! Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum
xref: Reactome:REACT_98302 ! Formation of open bubble structure in DNA by helicases, Sus scrofa
xref: Reactome:REACT_98745 ! Cap-bound mRNA is activated by helicases, Xenopus tropicalis
xref: Reactome:REACT_99106 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Canis familiaris
xref: Reactome:REACT_99120 ! Addition of the third nucleotide on the nascent transcript, Danio rerio
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004497
name: monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "hydroxylase activity" RELATED [GOC:vk, GOC:mah]
xref: Reactome:REACT_100875 ! FMO2 S-oxidizes the antithyroid drug methimazole, Dictyostelium discoideum
xref: Reactome:REACT_101711 ! CYP2W1 can oxidize indole, Sus scrofa
xref: Reactome:REACT_102176 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Canis familiaris
xref: Reactome:REACT_104843 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Sus scrofa
xref: Reactome:REACT_105821 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Rattus norvegicus
xref: Reactome:REACT_106539 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Gallus gallus
xref: Reactome:REACT_106973 ! CYP2W1 can oxidize indole, Mus musculus
xref: Reactome:REACT_107936 ! FMO2 S-oxidizes the antithyroid drug methimazole, Caenorhabditis elegans
xref: Reactome:REACT_109390 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Mus musculus
xref: Reactome:REACT_110926 ! CYP2W1 can oxidize indole, Danio rerio
xref: Reactome:REACT_13511 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Homo sapiens
xref: Reactome:REACT_13592 ! CYP2W1 can oxidize indole, Homo sapiens
xref: Reactome:REACT_13740 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Homo sapiens
xref: Reactome:REACT_13821 ! FMO2 S-oxidizes the antithyroid drug methimazole, Homo sapiens
xref: Reactome:REACT_30553 ! FMO2 S-oxidizes the antithyroid drug methimazole, Canis familiaris
xref: Reactome:REACT_34685 ! FMO2 S-oxidizes the antithyroid drug methimazole, Mus musculus
xref: Reactome:REACT_77846 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Canis familiaris
xref: Reactome:REACT_78030 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Danio rerio
xref: Reactome:REACT_79048 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Danio rerio
xref: Reactome:REACT_80846 ! CYP2W1 can oxidize indole, Canis familiaris
xref: Reactome:REACT_81830 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Caenorhabditis elegans
xref: Reactome:REACT_82079 ! CYP2W1 can oxidize indole, Xenopus tropicalis
xref: Reactome:REACT_84097 ! FMO2 S-oxidizes the antithyroid drug methimazole, Bos taurus
xref: Reactome:REACT_84242 ! CYP2W1 can oxidize indole, Gallus gallus
xref: Reactome:REACT_84580 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Bos taurus
xref: Reactome:REACT_85402 ! CYP2W1 can oxidize indole, Taeniopygia guttata
xref: Reactome:REACT_86737 ! FMO2 S-oxidizes the antithyroid drug methimazole, Xenopus tropicalis
xref: Reactome:REACT_86917 ! CYP2W1 can oxidize indole, Rattus norvegicus
xref: Reactome:REACT_88779 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Xenopus tropicalis
xref: Reactome:REACT_89003 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Bos taurus
xref: Reactome:REACT_90320 ! CYP4F11 omega-hydroxylates 3-hydroxypalmitate, Taeniopygia guttata
xref: Reactome:REACT_90960 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Drosophila melanogaster
xref: Reactome:REACT_90990 ! CYP2W1 can oxidize indole, Bos taurus
xref: Reactome:REACT_92968 ! FMO2 S-oxidizes the antithyroid drug methimazole, Sus scrofa
xref: Reactome:REACT_95195 ! FMO2 S-oxidizes the antithyroid drug methimazole, Rattus norvegicus
xref: Reactome:REACT_96655 ! CYP3A43 catalyzes the 6beta-hydroxylation of testosterone, Mus musculus
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004803
name: transposase activity
namespace: molecular_function
alt_id: GO:0004804
def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "P-element encoded transposase activity" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004871
name: signal transducer activity
namespace: molecular_function
alt_id: GO:0005062
alt_id: GO:0009369
alt_id: GO:0009370
def: "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
comment: Ligands do NOT have the molecular function 'signal transducer activity'.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW []
synonym: "quorum sensing response regulator activity" NARROW []
synonym: "quorum sensing signal generator activity" NARROW []
relationship: part_of GO:0050896 ! response to stimulus
relationship: part_of GO:0009987 ! cellular process
relationship: part_of GO:0065007 ! biological regulation
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "small-molecule carrier or transporter" RELATED []
xref: Reactome:REACT_6315 ! Virion-associated M2 protein mediated ion infusion, Homo sapiens
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0006810 ! transport

[Term]
id: GO:0005488
name: binding
namespace: molecular_function
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]
comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "ligand" NARROW []
xref: Wikipedia:Binding_(molecular)
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005496
name: steroid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0045308
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED []
synonym: "protein amino acid binding" EXACT []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein folding chaperone" NARROW [GOC:tb, GOC:mah, GOC:dph]
synonym: "protein tagging activity" RELATED []
xref: Reactome:REACT_100108 ! Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus
xref: Reactome:REACT_100287 ! Formation of the IGF:IGFBP-4 Complex, Canis familiaris
xref: Reactome:REACT_101129 ! Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus
xref: Reactome:REACT_102084 ! Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus
xref: Reactome:REACT_102457 ! An anchoring protein, SARA, recruits R-SMAD, Canis familiaris
xref: Reactome:REACT_103972 ! Type II receptor recruits type I receptor, Xenopus tropicalis
xref: Reactome:REACT_104488 ! Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus
xref: Reactome:REACT_104599 ! Type II receptor recruits type I receptor, Sus scrofa
xref: Reactome:REACT_105776 ! Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio
xref: Reactome:REACT_106189 ! Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus
xref: Reactome:REACT_107402 ! Formation of the IGF:IGFBP-4 Complex, Mus musculus
xref: Reactome:REACT_108283 ! Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis
xref: Reactome:REACT_108734 ! Exocyst complex formation, Rattus norvegicus
xref: Reactome:REACT_109392 ! Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus
xref: Reactome:REACT_110419 ! Type II receptor recruits type I receptor, Bos taurus
xref: Reactome:REACT_110570 ! Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa
xref: Reactome:REACT_15321 ! Formation of the IGF:IGFBP-1 Complex, Homo sapiens
xref: Reactome:REACT_15325 ! Formation of the IGF:IGFBP-4 Complex, Homo sapiens
xref: Reactome:REACT_15355 ! Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens
xref: Reactome:REACT_15394 ! Exocyst complex formation, Homo sapiens
xref: Reactome:REACT_15417 ! Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens
xref: Reactome:REACT_15419 ! Formation of the IGF:IGFBP-2 Complex, Homo sapiens
xref: Reactome:REACT_15506 ! Formation of the IGF:IGFBP-6 Complex, Homo sapiens
xref: Reactome:REACT_15520 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Homo sapiens
xref: Reactome:REACT_15541 ! Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens
xref: Reactome:REACT_20509 ! Exocytosis of Insulin, Mus musculus
xref: Reactome:REACT_20539 ! Traversal of the cortical actin network., Mus musculus
xref: Reactome:REACT_28794 ! Formation of the IGF:IGFBP-4 Complex, Sus scrofa
xref: Reactome:REACT_29512 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Caenorhabditis elegans
xref: Reactome:REACT_29669 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Danio rerio
xref: Reactome:REACT_29941 ! Formation of the IGF:IGFBP-4 Complex, Bos taurus
xref: Reactome:REACT_30571 ! Formation of the IGF:IGFBP-6 Complex, Danio rerio
xref: Reactome:REACT_30672 ! Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata
xref: Reactome:REACT_31305 ! Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata
xref: Reactome:REACT_31537 ! Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus
xref: Reactome:REACT_31641 ! Type II receptor recruits type I receptor, Danio rerio
xref: Reactome:REACT_31648 ! An anchoring protein, SARA, recruits R-SMAD, Mus musculus
xref: Reactome:REACT_32973 ! Formation of the IGF:IGFBP-1 Complex, Canis familiaris
xref: Reactome:REACT_33135 ! An anchoring protein, SARA, recruits R-SMAD, Rattus norvegicus
xref: Reactome:REACT_34719 ! Formation of the IGF:IGFBP-1 Complex, Danio rerio
xref: Reactome:REACT_6923 ! An anchoring protein, SARA, recruits R-SMAD, Homo sapiens
xref: Reactome:REACT_6945 ! Type II receptor recruits type I receptor, Homo sapiens
xref: Reactome:REACT_77120 ! Formation of the IGF:IGFBP-2 Complex, Bos taurus
xref: Reactome:REACT_77540 ! Exocyst complex formation, Canis familiaris
xref: Reactome:REACT_77845 ! Exocyst complex formation, Danio rerio
xref: Reactome:REACT_78036 ! Exocyst complex formation, Drosophila melanogaster
xref: Reactome:REACT_78044 ! Exocyst complex formation, Xenopus tropicalis
xref: Reactome:REACT_78382 ! Formation of the IGF:IGFBP-1 Complex, Mus musculus
xref: Reactome:REACT_78466 ! Formation of the IGF:IGFBP-6 Complex, Canis familiaris
xref: Reactome:REACT_79611 ! Exocyst complex formation, Bos taurus
xref: Reactome:REACT_79634 ! Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris
xref: Reactome:REACT_80470 ! Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus
xref: Reactome:REACT_80778 ! Type II receptor recruits type I receptor, Mus musculus
xref: Reactome:REACT_83147 ! Type II receptor recruits type I receptor, Rattus norvegicus
xref: Reactome:REACT_83165 ! Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa
xref: Reactome:REACT_83532 ! Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis
xref: Reactome:REACT_85250 ! Formation of the IGF:IGFBP-2 Complex, Canis familiaris
xref: Reactome:REACT_85814 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Dictyostelium discoideum
xref: Reactome:REACT_85858 ! Formation of the IGF:IGFBP-2 Complex, Gallus gallus
xref: Reactome:REACT_85962 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Taeniopygia guttata
xref: Reactome:REACT_85975 ! An anchoring protein, SARA, recruits R-SMAD, Danio rerio
xref: Reactome:REACT_86333 ! Exocyst complex formation, Taeniopygia guttata
xref: Reactome:REACT_86955 ! Exocyst complex formation, Mus musculus
xref: Reactome:REACT_87187 ! An anchoring protein, SARA, recruits R-SMAD, Xenopus tropicalis
xref: Reactome:REACT_87374 ! Formation of the IGF:IGFBP-6 Complex, Sus scrofa
xref: Reactome:REACT_88068 ! Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris
xref: Reactome:REACT_88138 ! Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio
xref: Reactome:REACT_88223 ! Formation of the IGF:IGFBP-1 Complex, Sus scrofa
xref: Reactome:REACT_89261 ! Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata
xref: Reactome:REACT_90027 ! Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus
xref: Reactome:REACT_90105 ! Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis
xref: Reactome:REACT_90666 ! An anchoring protein, SARA, recruits R-SMAD, Sus scrofa
xref: Reactome:REACT_91560 ! Type II receptor recruits type I receptor, Canis familiaris
xref: Reactome:REACT_92029 ! Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus
xref: Reactome:REACT_93175 ! Formation of the IGF:IGFBP-1 Complex, Gallus gallus
xref: Reactome:REACT_93596 ! Formation of the IGF:IGFBP-6 Complex, Bos taurus
xref: Reactome:REACT_93938 ! Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus
xref: Reactome:REACT_94337 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Mus musculus
xref: Reactome:REACT_94522 ! Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata
xref: Reactome:REACT_94808 ! Formation of the IGF:IGFBP-6 Complex, Mus musculus
xref: Reactome:REACT_95241 ! Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus
xref: Reactome:REACT_95561 ! Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis
xref: Reactome:REACT_95914 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Drosophila melanogaster
xref: Reactome:REACT_96236 ! Formation of the IGF:IGFBP-2 Complex, Mus musculus
xref: Reactome:REACT_96264 ! Formation of the IGF:IGFBP-2 Complex, Danio rerio
xref: Reactome:REACT_98028 ! Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata
xref: Reactome:REACT_98807 ! An anchoring protein, SARA, recruits R-SMAD, Bos taurus
xref: Reactome:REACT_99562 ! Exocyst complex formation, Gallus gallus
is_a: GO:0005488 ! binding

[Term]
id: GO:0005549
name: odorant binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular component" EXACT []
synonym: "cellular component unknown" NARROW []
xref: NIF_Subcellular:sao1337158144
disjoint_from: GO:0003674 ! molecular_function

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cell_wall
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0005622
name: intracellular
namespace: cellular_component
def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "internal to cell" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005643
name: nuclear pore
namespace: cellular_component
alt_id: GO:0005644
def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
subset: goslim_pir
synonym: "NPC" EXACT []
synonym: "nuclear pore complex" EXACT []
synonym: "nuclear pore membrane protein" NARROW []
synonym: "nucleopore" EXACT [GOC:al, PMID:7603572]
xref: NIF_Subcellular:sao220861693
xref: Wikipedia:Nuclear_pore
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]
subset: goslim_pir
subset: gosubset_prok
synonym: "RFC complex" EXACT []
synonym: "activator 1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0005667
name: transcription factor complex
namespace: cellular_component
def: "A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005681
name: spliceosomal complex
namespace: cellular_component
def: "Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]
subset: goslim_pir
synonym: "spliceosome complex" EXACT []
xref: Wikipedia:Spliceosome
is_a: GO:0005575 ! cellular_component
is_a: GO:0030529 ! ribonucleoprotein complex
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]
subset: goslim_pir
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus
is_a: GO:0005575 ! cellular_component
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005732
name: small nucleolar ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
comment: Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex.
subset: goslim_pir
synonym: "small nucleolar ribonucleoprotein" EXACT []
synonym: "snoRNP" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005744
name: mitochondrial inner membrane presequence translocase complex
namespace: cellular_component
def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
subset: goslim_pir
synonym: "Tim23 complex" NARROW []
synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT []
synonym: "mitochondrial inner membrane translocase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005768
name: endosome
namespace: cellular_component
def: "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
xref: NIF_Subcellular:sao1720343330
xref: Wikipedia:Endosome
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "ER" EXACT []
xref: NIF_Subcellular:sao1036339110
xref: Wikipedia:Endoplasmic_reticulum
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005784
name: Sec61 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647]
subset: goslim_pir
synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005813
name: centrosome
namespace: cellular_component
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
subset: goslim_pir
xref: Wikipedia:Centrosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0005835
name: fatty acid synthase complex
namespace: cellular_component
alt_id: GO:0031373
alt_id: GO:0031374
def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840]
subset: goslim_pir
subset: gosubset_prok
synonym: "FAS complex" EXACT []
synonym: "cytosolic FAS complex" EXACT []
synonym: "cytosolic fatty acid synthase complex" EXACT []
synonym: "cytosolic type I FAS complex" EXACT []
synonym: "cytosolic type I fatty acid synthase complex" EXACT []
synonym: "fatty acid synthetase complex" EXACT []
synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED []
xref: Wikipedia:Fatty_acid_synthetase_complex
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
alt_id: GO:0033279
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal RNA" RELATED []
synonym: "ribosomal subunit" RELATED [GOC:mah, GOC:vw]
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0005575 ! cellular_component
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0030529 ! ribonucleoprotein complex
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005844
name: polysome
namespace: cellular_component
def: "Several ribosomes bound to one mRNA." [ISBN:0198506732]
subset: goslim_pir
synonym: "polyribosome" EXACT []
xref: Wikipedia:Polysome
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005849
name: mRNA cleavage factor complex
namespace: cellular_component
def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005891
name: voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
subset: goslim_pir
synonym: "voltage gated calcium channel complex" EXACT []
synonym: "voltage-dependent calcium channel complex" EXACT []
synonym: "voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
xref: Wikipedia:Microvillus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Brush_border
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005937
name: mating projection
namespace: cellular_component
def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc]
subset: goslim_pir
synonym: "conjugation tube" NARROW []
synonym: "shmoo" NARROW []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005942
name: phosphatidylinositol 3-kinase complex
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphatidylinositol 3-kinase (PI3K)." [GOC:bf]
subset: goslim_pir
synonym: "1-phosphatidylinositol 3-kinase complex" EXACT []
synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575]
synonym: "PI3K complex" EXACT []
synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429]
synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439]
synonym: "phosphoinositide 3-kinase complex" EXACT [GOC:curators]
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005960
name: glycine cleavage complex
namespace: cellular_component
alt_id: GO:0005961
alt_id: GO:0070015
def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycine cleavage system" EXACT []
synonym: "glycine decarboxylase complex" EXACT []
synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT []
synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED []
synonym: "glycine synthase complex" EXACT []
xref: Wikipedia:Glycine_decarboxylase_complex
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:REACT_101193 ! Metabolism of carbohydrates, Sus scrofa
xref: Reactome:REACT_102834 ! Metabolism of carbohydrates, Mus musculus
xref: Reactome:REACT_103806 ! Metabolism of carbohydrates, Mycobacterium tuberculosis
xref: Reactome:REACT_104502 ! Metabolism of carbohydrates, Gallus gallus
xref: Reactome:REACT_105321 ! Metabolism of carbohydrates, Escherichia coli
xref: Reactome:REACT_106046 ! Metabolism of carbohydrates, Drosophila melanogaster
xref: Reactome:REACT_107409 ! Metabolism of carbohydrates, Caenorhabditis elegans
xref: Reactome:REACT_28218 ! Metabolism of carbohydrates, Xenopus tropicalis
xref: Reactome:REACT_32291 ! Metabolism of carbohydrates, Staphylococcus aureus N315
xref: Reactome:REACT_33141 ! Metabolism of carbohydrates, Taeniopygia guttata
xref: Reactome:REACT_33953 ! Metabolism of carbohydrates, Rattus norvegicus
xref: Reactome:REACT_34800 ! Metabolism of carbohydrates, Danio rerio
xref: Reactome:REACT_474 ! Metabolism of carbohydrates, Homo sapiens
xref: Reactome:REACT_77669 ! Metabolism of carbohydrates, Plasmodium falciparum
xref: Reactome:REACT_81945 ! Metabolism of carbohydrates, Schizosaccharomyces pombe
xref: Reactome:REACT_83038 ! Metabolism of carbohydrates, Arabidopsis thaliana
xref: Reactome:REACT_83329 ! Metabolism of carbohydrates, Saccharomyces cerevisiae
xref: Reactome:REACT_88330 ! Metabolism of carbohydrates, Bos taurus
xref: Reactome:REACT_88558 ! Metabolism of carbohydrates, Canis familiaris
xref: Reactome:REACT_96375 ! Metabolism of carbohydrates, Dictyostelium discoideum
xref: Reactome:REACT_98394 ! Metabolism of carbohydrates, Oryza sativa
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycan metabolic process" EXACT []
synonym: "glycan metabolism" EXACT []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0006066
name: alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "alcohol metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006081
name: cellular aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "aldehyde metabolism" EXACT []
synonym: "alkanal metabolic process" EXACT []
synonym: "alkanal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006112
name: energy reserve metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "energy reserve metabolism" EXACT []
xref: Reactome:REACT_100070 ! Integration of energy metabolism, Taeniopygia guttata
xref: Reactome:REACT_105810 ! Integration of energy metabolism, Mus musculus
xref: Reactome:REACT_108807 ! Integration of energy metabolism, Plasmodium falciparum
xref: Reactome:REACT_109211 ! Integration of energy metabolism, Arabidopsis thaliana
xref: Reactome:REACT_110910 ! Integration of energy metabolism, Rattus norvegicus
xref: Reactome:REACT_1505 ! Integration of energy metabolism, Homo sapiens
xref: Reactome:REACT_28839 ! Integration of energy metabolism, Dictyostelium discoideum
xref: Reactome:REACT_31409 ! Integration of energy metabolism, Caenorhabditis elegans
xref: Reactome:REACT_33977 ! Integration of energy metabolism, Xenopus tropicalis
xref: Reactome:REACT_77410 ! Integration of energy metabolism, Bos taurus
xref: Reactome:REACT_79340 ! Integration of energy metabolism, Escherichia coli
xref: Reactome:REACT_80356 ! Integration of energy metabolism, Canis familiaris
xref: Reactome:REACT_80630 ! Integration of energy metabolism, Sus scrofa
xref: Reactome:REACT_83420 ! Integration of energy metabolism, Mycobacterium tuberculosis
xref: Reactome:REACT_85294 ! Integration of energy metabolism, Danio rerio
xref: Reactome:REACT_87289 ! Integration of energy metabolism, Saccharomyces cerevisiae
xref: Reactome:REACT_88950 ! Integration of energy metabolism, Staphylococcus aureus N315
xref: Reactome:REACT_89538 ! Integration of energy metabolism, Drosophila melanogaster
xref: Reactome:REACT_93425 ! Integration of energy metabolism, Oryza sativa
xref: Reactome:REACT_94255 ! Integration of energy metabolism, Gallus gallus
xref: Reactome:REACT_94635 ! Integration of energy metabolism, Schizosaccharomyces pombe
is_a: GO:0008152 ! metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0006113
name: fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:curators, MetaCyc:Fermentation]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:FERMENTATION-PWY
xref: Wikipedia:Fermentation_(biochemistry)
is_a: GO:0008152 ! metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0006119
name: oxidative phosphorylation
namespace: biological_process
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309]
subset: goslim_pir
subset: gosubset_prok
synonym: "respiratory-chain phosphorylation" EXACT []
xref: Wikipedia:Oxidative_phosphorylation
relationship: has_part GO:0006807 ! nitrogen compound metabolic process
relationship: has_part GO:0046483 ! heterocycle metabolic process
relationship: has_part GO:0006818 ! hydrogen transport
relationship: has_part GO:0006811 ! ion transport
relationship: has_part GO:0009117 ! nucleotide metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006139
name: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "DNA metabolism" EXACT []
synonym: "cellular DNA metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0006260
name: DNA replication
namespace: biological_process
alt_id: GO:0055133
def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah]
comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_100559 ! Activation of ATR in response to replication stress, Mus musculus
xref: Reactome:REACT_101280 ! Activation of claspin, Xenopus tropicalis
xref: Reactome:REACT_101497 ! Activation of claspin, Bos taurus
xref: Reactome:REACT_102679 ! Activation of ATR in response to replication stress, Gallus gallus
xref: Reactome:REACT_103614 ! Stalling of DNA replication fork and RPA binding, Taeniopygia guttata
xref: Reactome:REACT_104547 ! Recruitment and activation of Chk1, Gallus gallus
xref: Reactome:REACT_105292 ! Activation of ATR in response to replication stress, Xenopus tropicalis
xref: Reactome:REACT_105467 ! Loading of claspin onto DNA during replication origin firing, Danio rerio
xref: Reactome:REACT_105835 ! Stalling of DNA replication fork and RPA binding, Gallus gallus
xref: Reactome:REACT_106018 ! Recruitment of Rad17-RFC complex to DNA, Gallus gallus
xref: Reactome:REACT_106104 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Bos taurus
xref: Reactome:REACT_106382 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster
xref: Reactome:REACT_106434 ! Activation of claspin, Canis familiaris
xref: Reactome:REACT_106732 ! Recruitment and activation of Chk1, Canis familiaris
xref: Reactome:REACT_107075 ! Activation of ATR in response to replication stress, Danio rerio
xref: Reactome:REACT_107423 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans
xref: Reactome:REACT_108461 ! Recruitment and activation of Chk1, Bos taurus
xref: Reactome:REACT_108634 ! Loading of claspin onto DNA during replication origin firing, Mus musculus
xref: Reactome:REACT_108739 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Xenopus tropicalis
xref: Reactome:REACT_108768 ! Activation of ATR in response to replication stress, Bos taurus
xref: Reactome:REACT_108929 ! Activation of ATR in response to replication stress, Drosophila melanogaster
xref: Reactome:REACT_109137 ! Stalling of DNA replication fork and RPA binding, Rattus norvegicus
xref: Reactome:REACT_29423 ! Activation of ATR in response to replication stress, Schizosaccharomyces pombe
xref: Reactome:REACT_29444 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Taeniopygia guttata
xref: Reactome:REACT_29691 ! Activation of ATR in response to replication stress, Rattus norvegicus
xref: Reactome:REACT_29764 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata
xref: Reactome:REACT_30149 ! Activation of claspin, Rattus norvegicus
xref: Reactome:REACT_31024 ! Recruitment of Rad17-RFC complex to DNA, Xenopus tropicalis
xref: Reactome:REACT_31919 ! Loading of claspin onto DNA during replication origin firing, Rattus norvegicus
xref: Reactome:REACT_32546 ! Recruitment of Rad17-RFC complex to DNA, Mus musculus
xref: Reactome:REACT_32932 ! Recruitment and activation of Chk1, Taeniopygia guttata
xref: Reactome:REACT_33874 ! Recruitment and activation of Chk1, Xenopus tropicalis
xref: Reactome:REACT_50018 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus
xref: Reactome:REACT_53588 ! Loading of claspin onto DNA during replication origin firing, Canis familiaris
xref: Reactome:REACT_6729 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens
xref: Reactome:REACT_6738 ! Loading of claspin onto DNA during replication origin firing, Homo sapiens
xref: Reactome:REACT_6750 ! Activation of claspin, Homo sapiens
xref: Reactome:REACT_6769 ! Activation of ATR in response to replication stress, Homo sapiens
xref: Reactome:REACT_6798 ! Recruitment of Rad17-RFC complex to DNA, Homo sapiens
xref: Reactome:REACT_6869 ! Recruitment and activation of Chk1, Homo sapiens
xref: Reactome:REACT_6936 ! Stalling of DNA replication fork and RPA binding, Homo sapiens
xref: Reactome:REACT_6939 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Homo sapiens
xref: Reactome:REACT_77532 ! Stalling of DNA replication fork and RPA binding, Canis familiaris
xref: Reactome:REACT_79188 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris
xref: Reactome:REACT_79450 ! Activation of ATR in response to replication stress, Dictyostelium discoideum
xref: Reactome:REACT_80432 ! Loading of claspin onto DNA during replication origin firing, Taeniopygia guttata
xref: Reactome:REACT_80571 ! Activation of claspin, Mus musculus
xref: Reactome:REACT_80896 ! Recruitment and activation of Chk1, Sus scrofa
xref: Reactome:REACT_80988 ! Loading of claspin onto DNA during replication origin firing, Bos taurus
xref: Reactome:REACT_81803 ! Recruitment of Rad17-RFC complex to DNA, Canis familiaris
xref: Reactome:REACT_83095 ! Recruitment of Rad17-RFC complex to DNA, Danio rerio
xref: Reactome:REACT_84829 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Danio rerio
xref: Reactome:REACT_85266 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum
xref: Reactome:REACT_85561 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Rattus norvegicus
xref: Reactome:REACT_86410 ! Stalling of DNA replication fork and RPA binding, Mus musculus
xref: Reactome:REACT_86739 ! Recruitment and activation of Chk1, Rattus norvegicus
xref: Reactome:REACT_87233 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Canis familiaris
xref: Reactome:REACT_87449 ! Recruitment of Rad17-RFC complex to DNA, Rattus norvegicus
xref: Reactome:REACT_87590 ! Recruitment of Rad17-RFC complex to DNA, Bos taurus
xref: Reactome:REACT_88085 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Gallus gallus
xref: Reactome:REACT_88384 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe
xref: Reactome:REACT_88529 ! Activation of claspin, Gallus gallus
xref: Reactome:REACT_89355 ! Activation of claspin, Danio rerio
xref: Reactome:REACT_89439 ! Activation of ATR in response to replication stress, Sus scrofa
xref: Reactome:REACT_89725 ! Loading of claspin onto DNA during replication origin firing, Drosophila melanogaster
xref: Reactome:REACT_90512 ! Stalling of DNA replication fork and RPA binding, Bos taurus
xref: Reactome:REACT_90809 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio
xref: Reactome:REACT_90838 ! Recruitment of Rad17-RFC complex to DNA, Taeniopygia guttata
xref: Reactome:REACT_91184 ! Recruitment and activation of Chk1, Danio rerio
xref: Reactome:REACT_91302 ! Activation of ATR in response to replication stress, Canis familiaris
xref: Reactome:REACT_92527 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus
xref: Reactome:REACT_92644 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis
xref: Reactome:REACT_92706 ! Stalling of DNA replication fork and RPA binding, Danio rerio
xref: Reactome:REACT_94983 ! Stalling of DNA replication fork and RPA binding, Xenopus tropicalis
xref: Reactome:REACT_95253 ! Activation of ATR in response to replication stress, Taeniopygia guttata
xref: Reactome:REACT_95329 ! Activation of claspin, Taeniopygia guttata
xref: Reactome:REACT_96115 ! Binding of ATR-ATRIP to the RPA-ssDNA complex, Mus musculus
xref: Reactome:REACT_96804 ! Recruitment and activation of Chk1, Mus musculus
xref: Reactome:REACT_96998 ! Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus
xref: Reactome:REACT_97204 ! Loading of claspin onto DNA during replication origin firing, Gallus gallus
xref: Reactome:REACT_97726 ! Activation of ATR in response to replication stress, Caenorhabditis elegans
xref: Reactome:REACT_99948 ! Loading of claspin onto DNA during replication origin firing, Xenopus tropicalis
xref: Wikipedia:DNA_replication
relationship: has_part GO:0006259 ! DNA metabolic process
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006266
name: DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006276
name: plasmid maintenance
namespace: biological_process
def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006281
name: DNA repair
namespace: biological_process
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_102034 ! DNA Repair, Staphylococcus aureus N315
xref: Reactome:REACT_106650 ! DNA Damage Reversal, Taeniopygia guttata
xref: Reactome:REACT_107446 ! DNA Repair, Arabidopsis thaliana
xref: Reactome:REACT_107692 ! DNA Damage Reversal, Gallus gallus
xref: Reactome:REACT_107752 ! DNA Repair, Plasmodium falciparum
xref: Reactome:REACT_108864 ! DNA Damage Reversal, Rattus norvegicus
xref: Reactome:REACT_108881 ! DNA Damage Reversal, Bos taurus
xref: Reactome:REACT_108903 ! DNA Repair, Xenopus tropicalis
xref: Reactome:REACT_109956 ! DNA Repair, Gallus gallus
xref: Reactome:REACT_127 ! DNA Damage Reversal, Homo sapiens
xref: Reactome:REACT_216 ! DNA Repair, Homo sapiens
xref: Reactome:REACT_29531 ! DNA Damage Reversal, Saccharomyces cerevisiae
xref: Reactome:REACT_29636 ! DNA Damage Reversal, Staphylococcus aureus N315
xref: Reactome:REACT_33728 ! DNA Damage Reversal, Sus scrofa
xref: Reactome:REACT_34272 ! DNA Repair, Dictyostelium discoideum
xref: Reactome:REACT_78051 ! DNA Damage Reversal, Canis familiaris
xref: Reactome:REACT_82907 ! DNA Repair, Oryza sativa
xref: Reactome:REACT_83599 ! DNA Repair, Sus scrofa
xref: Reactome:REACT_83608 ! DNA Damage Reversal, Caenorhabditis elegans
xref: Reactome:REACT_83660 ! DNA Repair, Escherichia coli
xref: Reactome:REACT_84835 ! DNA Damage Reversal, Dictyostelium discoideum
xref: Reactome:REACT_85522 ! DNA Repair, Mus musculus
xref: Reactome:REACT_86513 ! DNA Repair, Mycobacterium tuberculosis
xref: Reactome:REACT_86902 ! DNA Repair, Danio rerio
xref: Reactome:REACT_88201 ! DNA Repair, Drosophila melanogaster
xref: Reactome:REACT_88946 ! DNA Damage Reversal, Mycobacterium tuberculosis
xref: Reactome:REACT_89358 ! DNA Damage Reversal, Escherichia coli
xref: Reactome:REACT_89524 ! DNA Damage Reversal, Drosophila melanogaster
xref: Reactome:REACT_90385 ! DNA Repair, Canis familiaris
xref: Reactome:REACT_90952 ! DNA Damage Reversal, Arabidopsis thaliana
xref: Reactome:REACT_91094 ! DNA Repair, Rattus norvegicus
xref: Reactome:REACT_91330 ! DNA Repair, Bos taurus
xref: Reactome:REACT_91442 ! DNA Repair, Caenorhabditis elegans
xref: Reactome:REACT_91576 ! DNA Damage Reversal, Oryza sativa
xref: Reactome:REACT_92707 ! DNA Repair, Taeniopygia guttata
xref: Reactome:REACT_93704 ! DNA Repair, Saccharomyces cerevisiae
xref: Reactome:REACT_94769 ! DNA Repair, Schizosaccharomyces pombe
xref: Reactome:REACT_95158 ! DNA Damage Reversal, Xenopus tropicalis
xref: Reactome:REACT_96452 ! DNA Damage Reversal, Danio rerio
xref: Reactome:REACT_99277 ! DNA Damage Reversal, Mus musculus
xref: Wikipedia:DNA_repair
is_a: GO:0050896 ! response to stimulus
is_a: GO:0009987 ! cellular process
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006304
name: DNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006323
name: DNA packaging
namespace: biological_process
def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "DNA organisation" EXACT [GOC:curators]
synonym: "DNA organization" EXACT [GOC:curators]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006354
name: transcription elongation, DNA-dependent
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA elongation" BROAD []
synonym: "transcriptional elongation, DNA-dependent" EXACT []
relationship: part_of GO:0016070 ! RNA metabolic process
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0006396
name: RNA processing
namespace: biological_process
alt_id: GO:0006394
def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Post-transcriptional_modification
relationship: part_of GO:0043170 ! macromolecule metabolic process
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT [GOC:curators]
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:REACT_100851 ! Translation, Saccharomyces cerevisiae
xref: Reactome:REACT_101045 ! Translation, Dictyostelium discoideum
xref: Reactome:REACT_101324 ! Translation, Canis familiaris
xref: Reactome:REACT_1014 ! Translation, Homo sapiens
xref: Reactome:REACT_103420 ! Translation, Plasmodium falciparum
xref: Reactome:REACT_105544 ! Translation, Arabidopsis thaliana
xref: Reactome:REACT_29980 ! Translation, Bos taurus
xref: Reactome:REACT_33559 ! Translation, Rattus norvegicus
xref: Reactome:REACT_77710 ! Translation, Drosophila melanogaster
xref: Reactome:REACT_79784 ! Translation, Danio rerio
xref: Reactome:REACT_81734 ! Translation, Schizosaccharomyces pombe
xref: Reactome:REACT_81833 ! Translation, Caenorhabditis elegans
xref: Reactome:REACT_82171 ! Translation, Xenopus tropicalis
xref: Reactome:REACT_83429 ! Translation, Taeniopygia guttata
xref: Reactome:REACT_83530 ! Translation, Gallus gallus
xref: Reactome:REACT_84182 ! Translation, Sus scrofa
xref: Reactome:REACT_86996 ! Translation, Oryza sativa
xref: Reactome:REACT_95535 ! Translation, Mus musculus
xref: Reactome:REACT_96394 ! Translation, Escherichia coli
xref: Wikipedia:Translation_(genetics)
relationship: part_of GO:0043170 ! macromolecule metabolic process
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Reactome:REACT_100411 ! Chaperonin-mediated protein folding, Arabidopsis thaliana
xref: Reactome:REACT_104912 ! Chaperonin-mediated protein folding, Caenorhabditis elegans
xref: Reactome:REACT_105663 ! Chaperonin-mediated protein folding, Rattus norvegicus
xref: Reactome:REACT_106009 ! Chaperonin-mediated protein folding, Canis familiaris
xref: Reactome:REACT_106427 ! Chaperonin-mediated protein folding, Mus musculus
xref: Reactome:REACT_106894 ! Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris
xref: Reactome:REACT_106927 ! Chaperonin-mediated protein folding, Drosophila melanogaster
xref: Reactome:REACT_107029 ! Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster
xref: Reactome:REACT_108248 ! Chaperonin-mediated protein folding, Gallus gallus
xref: Reactome:REACT_109411 ! Formation of tubulin folding intermediates by CCT/TriC, Bos taurus
xref: Reactome:REACT_110417 ! Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus
xref: Reactome:REACT_16956 ! Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens
xref: Reactome:REACT_17001 ! Formation of tubulin folding intermediates by CCT/TriC, Mus musculus
xref: Reactome:REACT_17004 ! Chaperonin-mediated protein folding, Homo sapiens
xref: Reactome:REACT_17056 ! Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus
xref: Reactome:REACT_23878 ! N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens
xref: Reactome:REACT_30906 ! Chaperonin-mediated protein folding, Oryza sativa
xref: Reactome:REACT_32155 ! Chaperonin-mediated protein folding, Saccharomyces cerevisiae
xref: Reactome:REACT_32255 ! Chaperonin-mediated protein folding, Schizosaccharomyces pombe
xref: Reactome:REACT_33395 ! Formation of tubulin folding intermediates by CCT/TriC, Mus musculus
xref: Reactome:REACT_77627 ! Chaperonin-mediated protein folding, Plasmodium falciparum
xref: Reactome:REACT_77963 ! Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae
xref: Reactome:REACT_78530 ! Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus
xref: Reactome:REACT_81155 ! Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans
xref: Reactome:REACT_83906 ! Chaperonin-mediated protein folding, Dictyostelium discoideum
xref: Reactome:REACT_85492 ! Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa
xref: Reactome:REACT_85496 ! Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum
xref: Reactome:REACT_86318 ! Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana
xref: Reactome:REACT_91676 ! Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe
xref: Reactome:REACT_92785 ! Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum
xref: Reactome:REACT_92961 ! Chaperonin-mediated protein folding, Xenopus tropicalis
xref: Reactome:REACT_92981 ! Chaperonin-mediated protein folding, Taeniopygia guttata
xref: Reactome:REACT_94123 ! Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata
xref: Reactome:REACT_94443 ! Formation of tubulin folding intermediates by CCT/TriC, Danio rerio
xref: Reactome:REACT_94772 ! Chaperonin-mediated protein folding, Sus scrofa
xref: Reactome:REACT_96773 ! Chaperonin-mediated protein folding, Danio rerio
xref: Reactome:REACT_97016 ! Chaperonin-mediated protein folding, Bos taurus
xref: Reactome:REACT_97220 ! Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis
xref: Reactome:REACT_98132 ! Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa
xref: Wikipedia:Protein_folding
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006464
name: protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "process resulting in protein modification" RELATED []
synonym: "protein tagging activity" RELATED []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006508
name: proteolysis
namespace: biological_process
def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah]
comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein maturation.
subset: goslim_pir
subset: gosubset_prok
synonym: "ATP-dependent proteolysis" NARROW [GOC:mah]
synonym: "peptidolysis" EXACT []
xref: Reactome:REACT_105459 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Gallus gallus
xref: Reactome:REACT_106013 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Canis familiaris
xref: Reactome:REACT_106377 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Mus musculus
xref: Reactome:REACT_107219 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Danio rerio
xref: Reactome:REACT_110326 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Bos taurus
xref: Reactome:REACT_733 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Homo sapiens
xref: Reactome:REACT_84556 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Xenopus tropicalis
xref: Reactome:REACT_92566 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Sus scrofa
xref: Reactome:REACT_95969 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Taeniopygia guttata
xref: Reactome:REACT_98959 ! Removal of aminoterminal propeptides from gamma-carboxylated proteins, Rattus norvegicus
xref: Wikipedia:Proteolysis
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "peptide metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "lipid metabolism" EXACT []
xref: Reactome:REACT_104930 ! Lipid digestion, mobilization, and transport, Drosophila melanogaster
xref: Reactome:REACT_107479 ! Lipid digestion, mobilization, and transport, Xenopus tropicalis
xref: Reactome:REACT_108775 ! Lipid digestion, mobilization, and transport, Canis familiaris
xref: Reactome:REACT_28745 ! Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae
xref: Reactome:REACT_31395 ! Lipid digestion, mobilization, and transport, Sus scrofa
xref: Reactome:REACT_32539 ! Lipid digestion, mobilization, and transport, Bos taurus
xref: Reactome:REACT_33836 ! Lipid digestion, mobilization, and transport, Rattus norvegicus
xref: Reactome:REACT_602 ! Lipid digestion, mobilization, and transport, Homo sapiens
xref: Reactome:REACT_77176 ! Lipid digestion, mobilization, and transport, Danio rerio
xref: Reactome:REACT_77191 ! Lipid digestion, mobilization, and transport, Arabidopsis thaliana
xref: Reactome:REACT_79244 ! Lipid digestion, mobilization, and transport, Plasmodium falciparum
xref: Reactome:REACT_81778 ! Lipid digestion, mobilization, and transport, Oryza sativa
xref: Reactome:REACT_82512 ! Lipid digestion, mobilization, and transport, Taeniopygia guttata
xref: Reactome:REACT_82723 ! Lipid digestion, mobilization, and transport, Escherichia coli
xref: Reactome:REACT_90757 ! Lipid digestion, mobilization, and transport, Mus musculus
xref: Reactome:REACT_94607 ! Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis
xref: Reactome:REACT_97906 ! Lipid digestion, mobilization, and transport, Gallus gallus
xref: Reactome:REACT_98052 ! Lipid digestion, mobilization, and transport, Caenorhabditis elegans
xref: Reactome:REACT_98129 ! Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe
xref: Reactome:REACT_99706 ! Lipid digestion, mobilization, and transport, Dictyostelium discoideum
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006662
name: glycerol ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycerol ether metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006725
name: cellular aromatic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "aromatic compound metabolism" EXACT []
synonym: "aromatic hydrocarbon metabolic process" NARROW []
synonym: "aromatic hydrocarbon metabolism" NARROW []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006730
name: one-carbon metabolic process
namespace: biological_process
alt_id: GO:0019753
alt_id: GO:0019754
def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
subset: goslim_pir
subset: gosubset_prok
synonym: "one carbon metabolic process" EXACT [GOC:mah]
synonym: "one carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:C1cyc
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "vitamin metabolism" EXACT []
xref: Reactome:REACT_101808 ! Metabolism of vitamins and cofactors, Bos taurus
xref: Reactome:REACT_101968 ! Metabolism of vitamins and cofactors, Saccharomyces cerevisiae
xref: Reactome:REACT_103646 ! Metabolism of vitamins and cofactors, Staphylococcus aureus N315
xref: Reactome:REACT_105907 ! Metabolism of vitamins and cofactors, Danio rerio
xref: Reactome:REACT_106152 ! Metabolism of vitamins and cofactors, Xenopus tropicalis
xref: Reactome:REACT_108558 ! Metabolism of vitamins and cofactors, Rattus norvegicus
xref: Reactome:REACT_110948 ! Metabolism of vitamins and cofactors, Sus scrofa
xref: Reactome:REACT_11193 ! Metabolism of vitamins and cofactors, Homo sapiens
xref: Reactome:REACT_30091 ! Metabolism of vitamins and cofactors, Oryza sativa
xref: Reactome:REACT_33738 ! Metabolism of vitamins and cofactors, Mycobacterium tuberculosis
xref: Reactome:REACT_34161 ! Metabolism of vitamins and cofactors, Mus musculus
xref: Reactome:REACT_78899 ! Metabolism of vitamins and cofactors, Caenorhabditis elegans
xref: Reactome:REACT_81509 ! Metabolism of vitamins and cofactors, Gallus gallus
xref: Reactome:REACT_82129 ! Metabolism of vitamins and cofactors, Taeniopygia guttata
xref: Reactome:REACT_83508 ! Metabolism of vitamins and cofactors, Arabidopsis thaliana
xref: Reactome:REACT_87513 ! Metabolism of vitamins and cofactors, Schizosaccharomyces pombe
xref: Reactome:REACT_88850 ! Metabolism of vitamins and cofactors, Dictyostelium discoideum
xref: Reactome:REACT_96278 ! Metabolism of vitamins and cofactors, Plasmodium falciparum
xref: Reactome:REACT_96904 ! Metabolism of vitamins and cofactors, Drosophila melanogaster
xref: Reactome:REACT_97734 ! Metabolism of vitamins and cofactors, Escherichia coli
xref: Reactome:REACT_97893 ! Metabolism of vitamins and cofactors, Canis familiaris
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006805
name: xenobiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "xenobiotic metabolism" EXACT []
xref: Reactome:REACT_100124 ! Conjugation of benzoate with glycine, Mus musculus
xref: Reactome:REACT_100325 ! Conjugation of phenylacetate with glutamine, Mus musculus
xref: Reactome:REACT_100603 ! Biological oxidations, Arabidopsis thaliana
xref: Reactome:REACT_101131 ! Phase 1 - Functionalization of compounds, Dictyostelium discoideum
xref: Reactome:REACT_101207 ! Phase II conjugation, Bos taurus
xref: Reactome:REACT_101609 ! Conjugation of benzoate with glycine, Staphylococcus aureus N315
xref: Reactome:REACT_102079 ! Phase 1 - Functionalization of compounds, Sus scrofa
xref: Reactome:REACT_102115 ! Phase 1 - Functionalization of compounds, Schizosaccharomyces pombe
xref: Reactome:REACT_102277 ! Biological oxidations, Sus scrofa
xref: Reactome:REACT_102424 ! Phase 1 - Functionalization of compounds, Danio rerio
xref: Reactome:REACT_102433 ! Conjugation of salicylate with glycine, Sus scrofa
xref: Reactome:REACT_102710 ! Phase II conjugation, Drosophila melanogaster
xref: Reactome:REACT_102875 ! Conjugation of phenylacetate with glutamine, Bos taurus
xref: Reactome:REACT_103704 ! Conjugation of salicylate with glycine, Gallus gallus
xref: Reactome:REACT_103896 ! Phase 1 - Functionalization of compounds, Saccharomyces cerevisiae
xref: Reactome:REACT_104199 ! Phase II conjugation, Staphylococcus aureus N315
xref: Reactome:REACT_104666 ! Phase 1 - Functionalization of compounds, Arabidopsis thaliana
xref: Reactome:REACT_104877 ! Conjugation of carboxylic acids, Canis familiaris
xref: Reactome:REACT_105707 ! Phase 1 - Functionalization of compounds, Canis familiaris
xref: Reactome:REACT_106111 ! Phase II conjugation, Schizosaccharomyces pombe
xref: Reactome:REACT_106484 ! Conjugation of salicylate with glycine, Danio rerio
xref: Reactome:REACT_106812 ! Biological oxidations, Staphylococcus aureus N315
xref: Reactome:REACT_108383 ! Phase 1 - Functionalization of compounds, Gallus gallus
xref: Reactome:REACT_110034 ! Biological oxidations, Saccharomyces cerevisiae
xref: Reactome:REACT_110188 ! Conjugation of phenylacetate with glutamine, Rattus norvegicus
xref: Reactome:REACT_110735 ! Conjugation of salicylate with glycine, Canis familiaris
xref: Reactome:REACT_110771 ! Phase II conjugation, Saccharomyces cerevisiae
xref: Reactome:REACT_13433 ! Biological oxidations, Homo sapiens
xref: Reactome:REACT_13705 ! Phase 1 - Functionalization of compounds, Homo sapiens
xref: Reactome:REACT_28583 ! Conjugation of carboxylic acids, Taeniopygia guttata
xref: Reactome:REACT_29864 ! Conjugation of salicylate with glycine, Taeniopygia guttata
xref: Reactome:REACT_30367 ! Conjugation of carboxylic acids, Danio rerio
xref: Reactome:REACT_30613 ! Amino Acid conjugation, Canis familiaris
xref: Reactome:REACT_31665 ! Phase II conjugation, Caenorhabditis elegans
xref: Reactome:REACT_32556 ! Biological oxidations, Escherichia coli
xref: Reactome:REACT_32957 ! Conjugation of phenylacetate with glutamine, Sus scrofa
xref: Reactome:REACT_33042 ! Phase II conjugation, Xenopus tropicalis
xref: Reactome:REACT_33621 ! Biological oxidations, Canis familiaris
xref: Reactome:REACT_33687 ! Phase 1 - Functionalization of compounds, Drosophila melanogaster
xref: Reactome:REACT_34424 ! Biological oxidations, Plasmodium falciparum
xref: Reactome:REACT_43989 ! Phase II conjugation, Gallus gallus
xref: Reactome:REACT_6800 ! Conjugation of phenylacetate with glutamine, Homo sapiens
xref: Reactome:REACT_6812 ! Conjugation of salicylate with glycine, Homo sapiens
xref: Reactome:REACT_6889 ! Conjugation of carboxylic acids, Homo sapiens
xref: Reactome:REACT_6933 ! Conjugation of benzoate with glycine, Homo sapiens
xref: Reactome:REACT_6959 ! Phase II conjugation, Homo sapiens
xref: Reactome:REACT_6971 ! Amino Acid conjugation, Homo sapiens
xref: Reactome:REACT_76924 ! Biological oxidations, Bos taurus
xref: Reactome:REACT_76938 ! Phase II conjugation, Canis familiaris
xref: Reactome:REACT_77460 ! Phase II conjugation, Danio rerio
xref: Reactome:REACT_77547 ! Phase 1 - Functionalization of compounds, Oryza sativa
xref: Reactome:REACT_77582 ! Biological oxidations, Taeniopygia guttata
xref: Reactome:REACT_77645 ! Phase 1 - Functionalization of compounds, Mus musculus
xref: Reactome:REACT_78106 ! Biological oxidations, Drosophila melanogaster
xref: Reactome:REACT_78673 ! Amino Acid conjugation, Staphylococcus aureus N315
xref: Reactome:REACT_78750 ! Phase 1 - Functionalization of compounds, Taeniopygia guttata
xref: Reactome:REACT_79195 ! Conjugation of salicylate with glycine, Mus musculus
xref: Reactome:REACT_79356 ! Conjugation of phenylacetate with glutamine, Gallus gallus
xref: Reactome:REACT_80247 ! Biological oxidations, Dictyostelium discoideum
xref: Reactome:REACT_80647 ! Biological oxidations, Xenopus tropicalis
xref: Reactome:REACT_81143 ! Biological oxidations, Mus musculus
xref: Reactome:REACT_81348 ! Amino Acid conjugation, Taeniopygia guttata
xref: Reactome:REACT_81813 ! Amino Acid conjugation, Mus musculus
xref: Reactome:REACT_82058 ! Phase II conjugation, Escherichia coli
xref: Reactome:REACT_82657 ! Biological oxidations, Rattus norvegicus
xref: Reactome:REACT_82846 ! Phase II conjugation, Plasmodium falciparum
xref: Reactome:REACT_83267 ! Conjugation of benzoate with glycine, Taeniopygia guttata
xref: Reactome:REACT_83594 ! Phase II conjugation, Taeniopygia guttata
xref: Reactome:REACT_83912 ! Amino Acid conjugation, Bos taurus
xref: Reactome:REACT_83999 ! Biological oxidations, Oryza sativa
xref: Reactome:REACT_84336 ! Phase 1 - Functionalization of compounds, Caenorhabditis elegans
xref: Reactome:REACT_84559 ! Phase 1 - Functionalization of compounds, Xenopus tropicalis
xref: Reactome:REACT_84880 ! Conjugation of carboxylic acids, Sus scrofa
xref: Reactome:REACT_86049 ! Conjugation of carboxylic acids, Bos taurus
xref: Reactome:REACT_86211 ! Conjugation of phenylacetate with glutamine, Danio rerio
xref: Reactome:REACT_87255 ! Phase II conjugation, Oryza sativa
xref: Reactome:REACT_87382 ! Phase II conjugation, Mycobacterium tuberculosis
xref: Reactome:REACT_87394 ! Amino Acid conjugation, Sus scrofa
xref: Reactome:REACT_87515 ! Phase 1 - Functionalization of compounds, Bos taurus
xref: Reactome:REACT_87608 ! Phase II conjugation, Mus musculus
xref: Reactome:REACT_88305 ! Amino Acid conjugation, Danio rerio
xref: Reactome:REACT_88538 ! Conjugation of salicylate with glycine, Rattus norvegicus
xref: Reactome:REACT_89162 ! Biological oxidations, Gallus gallus
xref: Reactome:REACT_89372 ! Biological oxidations, Danio rerio
xref: Reactome:REACT_89381 ! Conjugation of benzoate with glycine, Sus scrofa
xref: Reactome:REACT_89411 ! Phase II conjugation, Arabidopsis thaliana
xref: Reactome:REACT_89442 ! Phase II conjugation, Sus scrofa
xref: Reactome:REACT_89902 ! Biological oxidations, Mycobacterium tuberculosis
xref: Reactome:REACT_89981 ! Conjugation of benzoate with glycine, Danio rerio
xref: Reactome:REACT_90526 ! Biological oxidations, Caenorhabditis elegans
xref: Reactome:REACT_90693 ! Conjugation of phenylacetate with glutamine, Canis familiaris
xref: Reactome:REACT_93150 ! Amino Acid conjugation, Rattus norvegicus
xref: Reactome:REACT_93320 ! Biological oxidations, Schizosaccharomyces pombe
xref: Reactome:REACT_93377 ! Conjugation of carboxylic acids, Rattus norvegicus
xref: Reactome:REACT_94407 ! Phase 1 - Functionalization of compounds, Mycobacterium tuberculosis
xref: Reactome:REACT_94419 ! Conjugation of carboxylic acids, Staphylococcus aureus N315
xref: Reactome:REACT_94547 ! Amino Acid conjugation, Gallus gallus
xref: Reactome:REACT_95660 ! Phase II conjugation, Rattus norvegicus
xref: Reactome:REACT_96794 ! Phase II conjugation, Dictyostelium discoideum
xref: Reactome:REACT_96971 ! Conjugation of carboxylic acids, Mus musculus
xref: Reactome:REACT_97512 ! Conjugation of benzoate with glycine, Gallus gallus
xref: Reactome:REACT_97920 ! Conjugation of salicylate with glycine, Bos taurus
xref: Reactome:REACT_98034 ! Conjugation of carboxylic acids, Gallus gallus
xref: Reactome:REACT_98166 ! Conjugation of benzoate with glycine, Canis familiaris
xref: Reactome:REACT_98222 ! Conjugation of benzoate with glycine, Rattus norvegicus
xref: Reactome:REACT_98651 ! Conjugation of benzoate with glycine, Bos taurus
xref: Reactome:REACT_99593 ! Conjugation of salicylate with glycine, Staphylococcus aureus N315
xref: Reactome:REACT_99671 ! Conjugation of phenylacetate with glutamine, Staphylococcus aureus N315
xref: Reactome:REACT_99732 ! Conjugation of phenylacetate with glutamine, Taeniopygia guttata
xref: Reactome:REACT_99818 ! Phase 1 - Functionalization of compounds, Rattus norvegicus
xref: Wikipedia:Xenobiotic_metabolism
is_a: GO:0044237 ! cellular metabolic process
relationship: part_of GO:0050896 ! response to stimulus
relationship: part_of GO:0009987 ! cellular process

[Term]
id: GO:0006807
name: nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732]
comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node.
subset: goslim_pir
subset: gosubset_prok
synonym: "nitrogen compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "auxiliary transport protein activity" RELATED [GOC:mah]
synonym: "small molecule transport" NARROW []
synonym: "solute:solute exchange" NARROW []
synonym: "transport accessory protein activity" RELATED [GOC:mah]
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0006811
name: ion transport
namespace: biological_process
def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_102356 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Xenopus tropicalis
xref: Reactome:REACT_102895 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Staphylococcus aureus N315
xref: Reactome:REACT_106972 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Sus scrofa
xref: Reactome:REACT_109067 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Saccharomyces cerevisiae
xref: Reactome:REACT_110862 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Arabidopsis thaliana
xref: Reactome:REACT_19397 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Homo sapiens
xref: Reactome:REACT_29110 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Oryza sativa
xref: Reactome:REACT_31978 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Mus musculus
xref: Reactome:REACT_33992 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Danio rerio
xref: Reactome:REACT_34201 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Gallus gallus
xref: Reactome:REACT_79109 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Caenorhabditis elegans
xref: Reactome:REACT_82618 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Escherichia coli
xref: Reactome:REACT_87822 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Bos taurus
xref: Reactome:REACT_91472 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Dictyostelium discoideum
xref: Reactome:REACT_91958 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Drosophila melanogaster
xref: Reactome:REACT_92903 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Mycobacterium tuberculosis
xref: Reactome:REACT_93485 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Canis familiaris
xref: Reactome:REACT_94357 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Rattus norvegicus
xref: Reactome:REACT_96078 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Plasmodium falciparum
xref: Reactome:REACT_96919 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Taeniopygia guttata
xref: Reactome:REACT_98077 ! Transport of inorganic cations/anions and amino acids/oligopeptides, Schizosaccharomyces pombe
is_a: GO:0006810 ! transport

[Term]
id: GO:0006818
name: hydrogen transport
namespace: biological_process
def: "The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_104605 ! Amino acid transport across the plasma membrane, Rattus norvegicus
xref: Reactome:REACT_105142 ! Amino acid transport across the plasma membrane, Mus musculus
xref: Reactome:REACT_105179 ! Amino acid transport across the plasma membrane, Caenorhabditis elegans
xref: Reactome:REACT_106669 ! Amino acid transport across the plasma membrane, Dictyostelium discoideum
xref: Reactome:REACT_107151 ! Amino acid transport across the plasma membrane, Arabidopsis thaliana
xref: Reactome:REACT_107366 ! Amino acid transport across the plasma membrane, Gallus gallus
xref: Reactome:REACT_107449 ! Amino acid transport across the plasma membrane, Escherichia coli
xref: Reactome:REACT_13796 ! Amino acid transport across the plasma membrane, Homo sapiens
xref: Reactome:REACT_29020 ! Amino acid transport across the plasma membrane, Staphylococcus aureus N315
xref: Reactome:REACT_81602 ! Amino acid transport across the plasma membrane, Oryza sativa
xref: Reactome:REACT_81848 ! Amino acid transport across the plasma membrane, Danio rerio
xref: Reactome:REACT_83425 ! Amino acid transport across the plasma membrane, Bos taurus
xref: Reactome:REACT_90553 ! Amino acid transport across the plasma membrane, Drosophila melanogaster
xref: Reactome:REACT_95755 ! Amino acid transport across the plasma membrane, Taeniopygia guttata
xref: Reactome:REACT_96944 ! Amino acid transport across the plasma membrane, Sus scrofa
xref: Reactome:REACT_98408 ! Amino acid transport across the plasma membrane, Xenopus tropicalis
xref: Reactome:REACT_99072 ! Amino acid transport across the plasma membrane, Canis familiaris
is_a: GO:0015849 ! organic acid transport
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
relationship: part_of GO:0051179 ! localization
is_a: GO:0006810 ! transport

[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
alt_id: GO:0016238
def: "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464]
subset: goslim_pir
synonym: "chaperone-mediated autophagy" EXACT []
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006928
name: cellular component movement
namespace: biological_process
def: "The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
comment: Note that in GO cellular components include whole cells (cell is_a cellular component).
subset: goslim_pir
subset: gosubset_prok
synonym: "cell movement" RELATED []
synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732]
subset: goslim_pir
xref: Reactome:REACT_100109 ! Smooth Muscle Contraction, Canis familiaris
xref: Reactome:REACT_102067 ! Smooth Muscle Contraction, Taeniopygia guttata
xref: Reactome:REACT_20558 ! Smooth Muscle Contraction, Homo sapiens
xref: Reactome:REACT_29015 ! Smooth Muscle Contraction, Danio rerio
xref: Reactome:REACT_77478 ! Smooth Muscle Contraction, Xenopus tropicalis
xref: Reactome:REACT_80035 ! Smooth Muscle Contraction, Caenorhabditis elegans
xref: Reactome:REACT_81255 ! Smooth Muscle Contraction, Mus musculus
xref: Reactome:REACT_83607 ! Smooth Muscle Contraction, Bos taurus
xref: Reactome:REACT_85440 ! Smooth Muscle Contraction, Gallus gallus
xref: Reactome:REACT_87764 ! Smooth Muscle Contraction, Sus scrofa
xref: Reactome:REACT_88232 ! Smooth Muscle Contraction, Rattus norvegicus
xref: Reactome:REACT_90741 ! Smooth Muscle Contraction, Dictyostelium discoideum
xref: Reactome:REACT_97034 ! Smooth Muscle Contraction, Drosophila melanogaster
xref: Wikipedia:Muscle_contraction
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732]
subset: goslim_pir
relationship: part_of GO:0032502 ! developmental process
is_a: GO:0032502 ! developmental process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "organelle organisation" EXACT [GOC:curators]
synonym: "organelle organization and biogenesis" RELATED [GOC:mah, GOC:jl, GOC:dph]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT [GOC:curators]
synonym: "nuclear organization" EXACT [GOC:curators]
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007005
name: mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "mitochondria organization" EXACT [GOC:mah]
synonym: "mitochondrion organisation" EXACT [GOC:mah]
synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytoplasm organisation" EXACT [GOC:curators]
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007029
name: endoplasmic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "ER organisation" EXACT [GOC:curators]
synonym: "ER organization and biogenesis" RELATED [GOC:mah]
synonym: "endoplasmic reticulum morphology" RELATED []
synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators]
synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi organisation" EXACT [GOC:curators]
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007031
name: peroxisome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "peroxisome organisation" EXACT [GOC:curators]
synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah]
synonym: "peroxisome-assembly ATPase activity" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007032
name: endosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endosome organisation" EXACT [GOC:curators]
synonym: "endosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT [GOC:curators]
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007047
name: cellular cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation" EXACT [GOC:curators]
is_a: GO:0071555 ! cell wall organization
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:ai, GOC:mah]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Cell_signaling
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell adhesion molecule activity" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0022610 ! biological adhesion
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Digestion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
alt_id: GO:0070261
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0008023
name: transcription elongation factor complex
namespace: cellular_component
def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0008037
name: cell recognition
namespace: biological_process
def: "The process in which a cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
subset: goslim_pir
synonym: "recognition of surroundings by cell" EXACT [GOC:curators]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0032501 ! multicellular organismal process

[Term]
id: GO:0008144
name: drug binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "biological process" EXACT []
synonym: "biological process unknown" NARROW []
synonym: "physiological process" EXACT []
xref: Wikipedia:Biological_process
disjoint_from: GO:0005575 ! cellular_component

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "metabolic process resulting in cell growth" NARROW []
synonym: "metabolism" EXACT []
synonym: "metabolism resulting in cell growth" NARROW []
xref: Wikipedia:Metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" EXACT []
xref: EC:3.4
xref: Reactome:REACT_106748 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus
xref: Reactome:REACT_110349 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus
xref: Reactome:REACT_13710 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens
xref: Reactome:REACT_19284 ! Proteolytic processing of Slit, Homo sapiens
xref: Reactome:REACT_93020 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus
xref: Reactome:REACT_99630 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0008278
name: cohesin complex
namespace: cellular_component
alt_id: GO:0008279
alt_id: GO:0043222
def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:sp, PMID:9887095]
subset: goslim_pir
synonym: "14S cohesin" NARROW []
synonym: "SMC complex" RELATED []
synonym: "SMC/kleisin ring complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0008283
name: cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells.
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0008287
name: protein serine/threonine phosphatase complex
namespace: cellular_component
def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008290
name: F-actin capping protein complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0008641
name: small protein activating enzyme activity
namespace: molecular_function
alt_id: GO:0008642
def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "ubiquitin-like activating enzyme activity" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
alt_id: GO:0006861
alt_id: GO:0008644
def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "sugar transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0008655
name: pyrimidine-containing compound salvage
namespace: biological_process
def: "Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [CHEBI:39447, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "pyrimidine salvage" RELATED [GOC:curators]
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0008907
name: integrase activity
namespace: molecular_function
def: "Catalysis of the integration of one segment of DNA into another." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009009
name: site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh]
comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009055
name: electron carrier activity
namespace: molecular_function
alt_id: GO:0009053
alt_id: GO:0009054
def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "2Fe-2S electron transfer carrier" NARROW []
synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW []
synonym: "adrenodoxin-type ferredoxin" NARROW []
synonym: "amicyanin" NARROW []
synonym: "azurin" NARROW []
synonym: "bacterial-type ferredoxin" NARROW []
synonym: "chloroplast-type ferredoxin" NARROW []
synonym: "copper electron carrier" NARROW []
synonym: "dicluster bacterial-type ferredoxin" NARROW []
synonym: "electron acceptor activity" NARROW []
synonym: "electron carrier, chlorophyll electron transport system" RELATED []
synonym: "electron donor activity" NARROW []
synonym: "electron transfer flavoprotein" NARROW []
synonym: "electron transfer flavoprotein, group I" NARROW []
synonym: "electron transfer flavoprotein, group II" NARROW []
synonym: "electron transporter activity" EXACT []
synonym: "high-potential iron-sulfur carrier" NARROW []
synonym: "iron-sulfur electron transfer carrier" NARROW []
synonym: "monocluster bacterial-type ferredoxin" NARROW []
synonym: "mononuclear iron electron carrier" NARROW []
synonym: "polyferredoxin" NARROW []
synonym: "redox-active disulfide bond electron carrier" NARROW []
synonym: "rubredoxin" NARROW []
synonym: "small blue copper electron carrier" NARROW []
synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW []
xref: Reactome:REACT_100606 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Caenorhabditis elegans
xref: Reactome:REACT_107372 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Xenopus tropicalis
xref: Reactome:REACT_107740 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mus musculus
xref: Reactome:REACT_107845 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Rattus norvegicus
xref: Reactome:REACT_109222 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Danio rerio
xref: Reactome:REACT_28440 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Escherichia coli
xref: Reactome:REACT_29712 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Bos taurus
xref: Reactome:REACT_31774 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Dictyostelium discoideum
xref: Reactome:REACT_6154 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Homo sapiens
xref: Reactome:REACT_78399 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Sus scrofa
xref: Reactome:REACT_81671 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Arabidopsis thaliana
xref: Reactome:REACT_89868 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Taeniopygia guttata
xref: Reactome:REACT_93247 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Saccharomyces cerevisiae
xref: Reactome:REACT_94498 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Drosophila melanogaster
xref: Reactome:REACT_98413 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Canis familiaris
xref: Reactome:REACT_98930 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Schizosaccharomyces pombe
xref: Reactome:REACT_99683 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mycobacterium tuberculosis
xref: Reactome:REACT_99848 ! Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Oryza sativa
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009116
name: nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleoside metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0009117
name: nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0009225
name: nucleotide-sugar metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide-sugar metabolism" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0009289
name: pilus
namespace: cellular_component
def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "fimbria" EXACT []
synonym: "fimbriae" EXACT []
synonym: "fimbrium" EXACT []
synonym: "pili" EXACT []
xref: Wikipedia:Pilus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0009292
name: genetic transfer
namespace: biological_process
def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt]
subset: goslim_pir
subset: gosubset_prok
synonym: "genetic exchange" BROAD []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "amine metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0009317
name: acetyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720]
subset: goslim_pir
subset: gosubset_prok
synonym: "ACCase complex" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009368
name: endopeptidase Clp complex
namespace: cellular_component
def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009372
name: quorum sensing
namespace: biological_process
def: "The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518]
subset: goslim_pir
subset: gosubset_prok
synonym: "quorum sensing system" EXACT []
xref: Wikipedia:Quorum_sensing
is_a: GO:0051704 ! multi-organism process
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0009404
name: toxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "toxin metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009521
name: photosystem
namespace: cellular_component
alt_id: GO:0030090
def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: goslim_pir
subset: gosubset_prok
synonym: "reaction center" NARROW []
synonym: "reaction centre" NARROW []
xref: Wikipedia:Photosystem
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Plastid
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009579
name: thylakoid
namespace: cellular_component
def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732]
comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles.
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "photosynthetic membrane" RELATED []
xref: Wikipedia:Thylakoid
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009657
name: plastid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah]
subset: goslim_pir
synonym: "plastid organisation" EXACT [GOC:curators]
synonym: "plastid organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0009975
name: cyclase activity
namespace: molecular_function
def: "Catalysis of a ring closure reaction." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009986
name: cell surface
namespace: cellular_component
alt_id: GO:0009928
alt_id: GO:0009929
def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
subset: goslim_pir
subset: gosubset_prok
synonym: "cell associated" EXACT []
synonym: "cell bound" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0010118
name: stomatal movement
namespace: biological_process
def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0010191
name: mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm]
subset: goslim_pir
synonym: "mucilage metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0010316
name: pyrophosphate-dependent phosphofructokinase complex
namespace: cellular_component
def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409]
subset: goslim_pir
synonym: "PFK complex" RELATED []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "enzyme transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015074
name: DNA integration
namespace: biological_process
def: "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015791
name: polyol transport
namespace: biological_process
def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015835
name: peptidoglycan transport
namespace: biological_process
def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "murein transport" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015891
name: siderophore transport
namespace: biological_process
alt_id: GO:0015892
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "iron-siderochrome transport" NARROW []
synonym: "iron-siderophore transport" EXACT []
synonym: "siderochrome transport" NARROW []
synonym: "siderophore-iron transport" EXACT []
is_a: GO:0006811 ! ion transport
relationship: part_of GO:0009987 ! cellular process
relationship: part_of GO:0065007 ! biological regulation

[Term]
id: GO:0015893
name: drug transport
namespace: biological_process
def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0050896 ! response to stimulus
is_a: GO:0006810 ! transport

[Term]
id: GO:0015920
name: lipopolysaccharide transport
namespace: biological_process
def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "LPS transport" EXACT []
relationship: part_of GO:0051179 ! localization
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015931
name: nucleobase, nucleoside, nucleotide and nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015935
name: small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a ribosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "ribosomal small subunit" EXACT []
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005840 ! ribosome
is_a: GO:0005575 ! cellular_component
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0015948
name: methanogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "methane biosynthesis" EXACT []
synonym: "methane biosynthetic process" EXACT []
xref: UM-BBD_pathwayID:meth
xref: Wikipedia:Methanogenesis
is_a: GO:0045333 ! cellular respiration
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0015949
name: nucleobase, nucleoside and nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide is synthesized from another nucleobase, nucleoside or nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:P1-PWY
xref: Reactome:REACT_102506 ! Synthesis and interconversion of nucleotide di- and triphosphates, Oryza sativa
xref: Reactome:REACT_107209 ! Synthesis and interconversion of nucleotide di- and triphosphates, Drosophila melanogaster
xref: Reactome:REACT_108426 ! Synthesis and interconversion of nucleotide di- and triphosphates, Danio rerio
xref: Reactome:REACT_109014 ! Synthesis and interconversion of nucleotide di- and triphosphates, Saccharomyces cerevisiae
xref: Reactome:REACT_109980 ! Synthesis and interconversion of nucleotide di- and triphosphates, Gallus gallus
xref: Reactome:REACT_110584 ! Synthesis and interconversion of nucleotide di- and triphosphates, Escherichia coli
xref: Reactome:REACT_21330 ! Synthesis and interconversion of nucleotide di- and triphosphates, Homo sapiens
xref: Reactome:REACT_29794 ! Synthesis and interconversion of nucleotide di- and triphosphates, Caenorhabditis elegans
xref: Reactome:REACT_41788 ! Synthesis and interconversion of nucleotide di- and triphosphates, Canis familiaris
xref: Reactome:REACT_77249 ! Synthesis and interconversion of nucleotide di- and triphosphates, Arabidopsis thaliana
xref: Reactome:REACT_77992 ! Synthesis and interconversion of nucleotide di- and triphosphates, Xenopus tropicalis
xref: Reactome:REACT_80972 ! Synthesis and interconversion of nucleotide di- and triphosphates, Taeniopygia guttata
xref: Reactome:REACT_82335 ! Synthesis and interconversion of nucleotide di- and triphosphates, Mus musculus
xref: Reactome:REACT_82859 ! Synthesis and interconversion of nucleotide di- and triphosphates, Bos taurus
xref: Reactome:REACT_86356 ! Synthesis and interconversion of nucleotide di- and triphosphates, Schizosaccharomyces pombe
xref: Reactome:REACT_89651 ! Synthesis and interconversion of nucleotide di- and triphosphates, Mycobacterium tuberculosis
xref: Reactome:REACT_90295 ! Synthesis and interconversion of nucleotide di- and triphosphates, Plasmodium falciparum
xref: Reactome:REACT_95252 ! Synthesis and interconversion of nucleotide di- and triphosphates, Rattus norvegicus
xref: Reactome:REACT_97285 ! Synthesis and interconversion of nucleotide di- and triphosphates, Dictyostelium discoideum
xref: Reactome:REACT_99115 ! Synthesis and interconversion of nucleotide di- and triphosphates, Sus scrofa
xref: Reactome:REACT_99360 ! Synthesis and interconversion of nucleotide di- and triphosphates, Staphylococcus aureus N315
is_a: GO:0008152 ! metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0015976
name: carbon utilization
namespace: biological_process
alt_id: GO:0015978
def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah]
synonym: "heterotrophy" EXACT []
xref: Wikipedia:Heterotroph
is_a: GO:0008150 ! biological_process
relationship: has_part GO:0006810 ! transport
relationship: has_part GO:0008152 ! metabolic process
relationship: has_part GO:0051606 ! detection of stimulus

[Term]
id: GO:0015979
name: photosynthesis
namespace: biological_process
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Photosynthesis
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0016010
name: dystrophin-associated glycoprotein complex
namespace: cellular_component
def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]
subset: goslim_pir
synonym: "DGC" EXACT []
synonym: "dystrophin glycoprotein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Biological_membrane
is_a: GO:0044464 ! cell part

[Term]
id: GO:0016028
name: rhabdomere
namespace: cellular_component
def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774]
subset: goslim_pir
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0016032
name: viral reproduction
namespace: biological_process
def: "The process in which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:mah]
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
subset: goslim_pir
synonym: "viral infection" RELATED []
synonym: "viral life cycle" EXACT []
synonym: "viral replication cycle" EXACT []
synonym: "virulence" RELATED []
xref: Reactome:REACT_6145 ! Influenza Life Cycle, Homo sapiens
xref: Reactome:REACT_6185 ! HIV Infection, Homo sapiens
xref: Reactome:REACT_6256 ! HIV Life Cycle, Homo sapiens
xref: Wikipedia:Viral_life_cycle
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016044
name: cellular membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "membrane organisation" EXACT [GOC:curators]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:REACT_101524 ! Membrane Trafficking, Dictyostelium discoideum
xref: Reactome:REACT_103082 ! Membrane Trafficking, Schizosaccharomyces pombe
xref: Reactome:REACT_11123 ! Membrane Trafficking, Homo sapiens
xref: Reactome:REACT_29278 ! Membrane Trafficking, Sus scrofa
xref: Reactome:REACT_32337 ! Membrane Trafficking, Taeniopygia guttata
xref: Reactome:REACT_33741 ! Membrane Trafficking, Bos taurus
xref: Reactome:REACT_34084 ! Membrane Trafficking, Caenorhabditis elegans
xref: Reactome:REACT_78213 ! Membrane Trafficking, Plasmodium falciparum
xref: Reactome:REACT_78288 ! Membrane Trafficking, Xenopus tropicalis
xref: Reactome:REACT_83546 ! Membrane Trafficking, Oryza sativa
xref: Reactome:REACT_86557 ! Membrane Trafficking, Arabidopsis thaliana
xref: Reactome:REACT_87431 ! Membrane Trafficking, Drosophila melanogaster
xref: Reactome:REACT_88307 ! Membrane Trafficking, Mus musculus
xref: Reactome:REACT_91154 ! Membrane Trafficking, Saccharomyces cerevisiae
xref: Reactome:REACT_93714 ! Membrane Trafficking, Danio rerio
xref: Reactome:REACT_95586 ! Membrane Trafficking, Gallus gallus
xref: Reactome:REACT_96516 ! Membrane Trafficking, Canis familiaris
xref: Reactome:REACT_97881 ! Membrane Trafficking, Rattus norvegicus
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
alt_id: GO:0048591
def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
synonym: "non-developmental cell growth" RELATED [GOC:mah]
synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah]
is_a: GO:0040007 ! growth
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT [GOC:curators]
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "RNA metabolism" EXACT []
xref: Reactome:REACT_107259 ! Metabolism of RNA, Sus scrofa
xref: Reactome:REACT_107652 ! Metabolism of RNA, Schizosaccharomyces pombe
xref: Reactome:REACT_110289 ! Metabolism of RNA, Danio rerio
xref: Reactome:REACT_21257 ! Metabolism of RNA, Homo sapiens
xref: Reactome:REACT_30579 ! Metabolism of RNA, Xenopus tropicalis
xref: Reactome:REACT_31367 ! Metabolism of RNA, Dictyostelium discoideum
xref: Reactome:REACT_33720 ! Metabolism of RNA, Plasmodium falciparum
xref: Reactome:REACT_80071 ! Metabolism of RNA, Caenorhabditis elegans
xref: Reactome:REACT_83630 ! Metabolism of RNA, Taeniopygia guttata
xref: Reactome:REACT_84169 ! Metabolism of RNA, Canis familiaris
xref: Reactome:REACT_85788 ! Metabolism of RNA, Oryza sativa
xref: Reactome:REACT_88316 ! Metabolism of RNA, Mus musculus
xref: Reactome:REACT_89992 ! Metabolism of RNA, Saccharomyces cerevisiae
xref: Reactome:REACT_91556 ! Metabolism of RNA, Bos taurus
xref: Reactome:REACT_92152 ! Metabolism of RNA, Drosophila melanogaster
xref: Reactome:REACT_94876 ! Metabolism of RNA, Arabidopsis thaliana
xref: Reactome:REACT_99403 ! Metabolism of RNA, Rattus norvegicus
xref: Reactome:REACT_99885 ! Metabolism of RNA, Gallus gallus
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0016209
name: antioxidant activity
namespace: molecular_function
def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016458
name: gene silencing
namespace: biological_process
def: "Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jid, GOC:tb]
comment: Note that this process is the opposite of long-term maintenance of gene activation.
subset: goslim_pir
synonym: "long-term maintenance of gene inactivation" RELATED []
xref: Wikipedia:Gene_silencing
is_a: GO:0009987 ! cellular process
is_a: GO:0065007 ! biological regulation
relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]
subset: goslim_pir
subset: gosubset_prok
synonym: "hydrogen-transporting two-sector ATPase complex" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0016472
name: sodium ion-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431]
subset: goslim_pir
synonym: "sodium-transporting two-sector ATPase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1
xref: Reactome:REACT_102858 ! Diiodinated tyrosine can be deiodinated, Mus musculus
xref: Reactome:REACT_102973 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris
xref: Reactome:REACT_103874 ! Monoiodinated tyrosine can be deiodinated, Canis familiaris
xref: Reactome:REACT_104604 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio
xref: Reactome:REACT_105062 ! Monoiodinated tyrosine can be deiodinated, Danio rerio
xref: Reactome:REACT_105121 ! Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans
xref: Reactome:REACT_106088 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus
xref: Reactome:REACT_106276 ! Monoiodinated tyrosine can be deiodinated, Rattus norvegicus
xref: Reactome:REACT_107002 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa
xref: Reactome:REACT_107467 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus
xref: Reactome:REACT_108745 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata
xref: Reactome:REACT_109500 ! Monoiodinated tyrosine can be deiodinated, Bos taurus
xref: Reactome:REACT_110582 ! Diiodinated tyrosine can be deiodinated, Rattus norvegicus
xref: Reactome:REACT_15389 ! Monoiodinated tyrosine can be deiodinated, Homo sapiens
xref: Reactome:REACT_15410 ! Diiodinated tyrosine can be deiodinated, Homo sapiens
xref: Reactome:REACT_17006 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens
xref: Reactome:REACT_17042 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens
xref: Reactome:REACT_29212 ! Diiodinated tyrosine can be deiodinated, Canis familiaris
xref: Reactome:REACT_30160 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus
xref: Reactome:REACT_31762 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus
xref: Reactome:REACT_32960 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus
xref: Reactome:REACT_34705 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus
xref: Reactome:REACT_44470 ! Monoiodinated tyrosine can be deiodinated, Mus musculus
xref: Reactome:REACT_78923 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata
xref: Reactome:REACT_84842 ! Diiodinated tyrosine can be deiodinated, Gallus gallus
xref: Reactome:REACT_86178 ! Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis
xref: Reactome:REACT_88304 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus
xref: Reactome:REACT_89057 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus
xref: Reactome:REACT_90394 ! Diiodinated tyrosine can be deiodinated, Xenopus tropicalis
xref: Reactome:REACT_91638 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana
xref: Reactome:REACT_91952 ! Monoiodinated tyrosine can be deiodinated, Gallus gallus
xref: Reactome:REACT_92075 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis
xref: Reactome:REACT_92434 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris
xref: Reactome:REACT_93539 ! Diiodinated tyrosine can be deiodinated, Drosophila melanogaster
xref: Reactome:REACT_93974 ! Diiodinated tyrosine can be deiodinated, Taeniopygia guttata
xref: Reactome:REACT_95169 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio
xref: Reactome:REACT_95558 ! Monoiodinated tyrosine can be deiodinated, Sus scrofa
xref: Reactome:REACT_95573 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans
xref: Reactome:REACT_97234 ! Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans
xref: Reactome:REACT_97568 ! Diiodinated tyrosine can be deiodinated, Sus scrofa
xref: Reactome:REACT_97851 ! Diiodinated tyrosine can be deiodinated, Bos taurus
xref: Reactome:REACT_98022 ! Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster
xref: Reactome:REACT_99085 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa
xref: Reactome:REACT_99794 ! Diiodinated tyrosine can be deiodinated, Danio rerio
xref: Reactome:REACT_99989 ! Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016530
name: metallochaperone activity
namespace: molecular_function
def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016585
name: chromatin remodeling complex
namespace: cellular_component
alt_id: GO:0005679
def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]
subset: goslim_pir
synonym: "chromatin remodelling complex" EXACT []
synonym: "nucleosome remodeling complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0016591
name: DNA-directed RNA polymerase II, holoenzyme
namespace: cellular_component
def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0016597
name: amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: EC:2
xref: Reactome:REACT_25050 ! Molybdenum ion transfer onto molybdopterin, Homo sapiens
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: EC:3
xref: Reactome:REACT_110436 ! Hydrolysis of phosphatidylcholine, Bos taurus
xref: Reactome:REACT_15331 ! Hydrolysis of phosphatidylcholine, Homo sapiens
xref: Reactome:REACT_83734 ! Hydrolysis of phosphatidylcholine, Danio rerio
xref: Reactome:REACT_84047 ! Hydrolysis of phosphatidylcholine, Xenopus tropicalis
xref: Reactome:REACT_87959 ! Hydrolysis of phosphatidylcholine, Gallus gallus
xref: Reactome:REACT_88159 ! Hydrolysis of phosphatidylcholine, Canis familiaris
xref: Reactome:REACT_90118 ! Hydrolysis of phosphatidylcholine, Mus musculus
xref: Reactome:REACT_91045 ! Hydrolysis of phosphatidylcholine, Taeniopygia guttata
xref: Reactome:REACT_98572 ! Hydrolysis of phosphatidylcholine, Rattus norvegicus
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other lyase activity" NARROW []
xref: EC:4
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other isomerase activity" NARROW []
xref: EC:5
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: EC:6
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]
subset: goslim_pir
synonym: "IGF binding protein complex" EXACT []
relationship: part_of GO:0005576 ! extracellular region
is_a: GO:0005575 ! cellular_component
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0017053
name: transcriptional repressor complex
namespace: cellular_component
def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0017144
name: drug metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "drug metabolism" EXACT []
xref: Reactome:REACT_100188 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Danio rerio
xref: Reactome:REACT_106588 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Canis familiaris
xref: Reactome:REACT_109592 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Taeniopygia guttata
xref: Reactome:REACT_110347 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Gallus gallus
xref: Reactome:REACT_163 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Homo sapiens
xref: Reactome:REACT_54870 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Bos taurus
xref: Reactome:REACT_80439 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Xenopus tropicalis
xref: Reactome:REACT_85142 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Mus musculus
xref: Reactome:REACT_88376 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Rattus norvegicus
xref: Reactome:REACT_92052 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Sus scrofa
xref: Wikipedia:Drug_metabolism
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0018942
name: organometal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "organometal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0019012
name: virion
namespace: cellular_component
def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325]
subset: goslim_pir
synonym: "complete virus particle" EXACT []
xref: Wikipedia:Virus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0019213
name: deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0019239
name: deaminase activity
namespace: molecular_function
def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "secondary metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0019825
name: oxygen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
xref: Reactome:REACT_100179 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Mus musculus
xref: Reactome:REACT_100188 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Danio rerio
xref: Reactome:REACT_100232 ! CYP4B1 can 12-hydroxylate arachidonic acid, Xenopus tropicalis
xref: Reactome:REACT_100276 ! Dehalogenation of carbon tetrachloride to form a free radical, Mus musculus
xref: Reactome:REACT_100352 ! CYP2F1 dehydrogenates 3-methylindole, Sus scrofa
xref: Reactome:REACT_100468 ! MEOS oxidizes ethanol to acetaldehyde, Xenopus tropicalis
xref: Reactome:REACT_100647 ! N-atom dealkylation of caffeine, Bos taurus
xref: Reactome:REACT_100686 ! CYP4B1 can 12-hydroxylate arachidonic acid, Gallus gallus
xref: Reactome:REACT_100861 ! CYP4B1 can 12-hydroxylate arachidonic acid, Sus scrofa
xref: Reactome:REACT_100981 ! N-hydroxylation of 4-aminobiphenyl, Taeniopygia guttata
xref: Reactome:REACT_101063 ! Benzene is hydroxylated to phenol, Xenopus tropicalis
xref: Reactome:REACT_101073 ! N-atom dealkylation of caffeine, Taeniopygia guttata
xref: Reactome:REACT_101109 ! CYP1B1 4-hydroxylates estradiol-17beta, Canis familiaris
xref: Reactome:REACT_101424 ! MEOS oxidizes ethanol to acetaldehyde, Bos taurus
xref: Reactome:REACT_101610 ! CYP2C19 5-hydroxylates omeprazole, Rattus norvegicus
xref: Reactome:REACT_101735 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Taeniopygia guttata
xref: Reactome:REACT_102272 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Bos taurus
xref: Reactome:REACT_102377 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Sus scrofa
xref: Reactome:REACT_102634 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Sus scrofa
xref: Reactome:REACT_102704 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Mus musculus
xref: Reactome:REACT_102873 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Xenopus tropicalis
xref: Reactome:REACT_103035 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Canis familiaris
xref: Reactome:REACT_103342 ! N-hydroxylation of 4-aminobiphenyl, Bos taurus
xref: Reactome:REACT_103579 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Rattus norvegicus
xref: Reactome:REACT_103850 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Sus scrofa
xref: Reactome:REACT_103936 ! CYP4F12 hydroxylates arachidonic acid, Taeniopygia guttata
xref: Reactome:REACT_104062 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Rattus norvegicus
xref: Reactome:REACT_104186 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Xenopus tropicalis
xref: Reactome:REACT_104205 ! CYP2U1 can omega-hydroxylate arachidonate, Drosophila melanogaster
xref: Reactome:REACT_104401 ! CYP4B1 can 12-hydroxylate arachidonic acid, Danio rerio
xref: Reactome:REACT_104637 ! Dehalogenation of carbon tetrachloride to form a free radical, Sus scrofa
xref: Reactome:REACT_104682 ! CYP4F12 hydroxylates arachidonic acid, Mus musculus
xref: Reactome:REACT_104739 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Danio rerio
xref: Reactome:REACT_104903 ! CYP4F12 hydroxylates arachidonic acid, Bos taurus
xref: Reactome:REACT_105192 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Xenopus tropicalis
xref: Reactome:REACT_105335 ! CYP3A4 can N-demethylate loperaminde, Caenorhabditis elegans
xref: Reactome:REACT_105445 ! CYP3A4 can N-demethylate loperaminde, Drosophila melanogaster
xref: Reactome:REACT_105726 ! Benzene is hydroxylated to phenol, Taeniopygia guttata
xref: Reactome:REACT_106014 ! CYP3A7 can 6beta-hydroxylate testosterone, Caenorhabditis elegans
xref: Reactome:REACT_106170 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Sus scrofa
xref: Reactome:REACT_106173 ! N-atom dealkylation of caffeine, Sus scrofa
xref: Reactome:REACT_106332 ! CYP2U1 can omega-hydroxylate arachidonate, Rattus norvegicus
xref: Reactome:REACT_106588 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Canis familiaris
xref: Reactome:REACT_106593 ! CYP4F8 hydroxylates prostaglandin H2, Danio rerio
xref: Reactome:REACT_106741 ! CYP2C19 5-hydroxylates omeprazole, Mus musculus
xref: Reactome:REACT_106777 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Canis familiaris
xref: Reactome:REACT_106979 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Taeniopygia guttata
xref: Reactome:REACT_107183 ! CYP2U1 can omega-hydroxylate arachidonate, Canis familiaris
xref: Reactome:REACT_107350 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Taeniopygia guttata
xref: Reactome:REACT_107408 ! CYP2C19 5-hydroxylates omeprazole, Sus scrofa
xref: Reactome:REACT_107478 ! MEOS oxidizes ethanol to acetaldehyde, Danio rerio
xref: Reactome:REACT_107548 ! N-hydroxylation of 4-aminobiphenyl, Rattus norvegicus
xref: Reactome:REACT_107861 ! CYP2U1 can omega-hydroxylate arachidonate, Taeniopygia guttata
xref: Reactome:REACT_107892 ! S-atom dealkylation of 6-methylmercaptopurine, Sus scrofa
xref: Reactome:REACT_107973 ! CYP2C19 5-hydroxylates omeprazole, Gallus gallus
xref: Reactome:REACT_108050 ! Benzene is hydroxylated to phenol, Gallus gallus
xref: Reactome:REACT_108219 ! N-hydroxylation of 4-aminobiphenyl, Mus musculus
xref: Reactome:REACT_108293 ! CYP3A7 can 6beta-hydroxylate testosterone, Bos taurus
xref: Reactome:REACT_108341 ! N-atom dealkylation of caffeine, Mus musculus
xref: Reactome:REACT_108385 ! Dehalogenation of carbon tetrachloride to form a free radical, Danio rerio
xref: Reactome:REACT_108547 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Danio rerio
xref: Reactome:REACT_108791 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Rattus norvegicus
xref: Reactome:REACT_108912 ! Benzene is hydroxylated to phenol, Canis familiaris
xref: Reactome:REACT_108924 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Gallus gallus
xref: Reactome:REACT_109005 ! CYP2F1 dehydrogenates 3-methylindole, Danio rerio
xref: Reactome:REACT_109209 ! MEOS oxidizes ethanol to acetaldehyde, Gallus gallus
xref: Reactome:REACT_109592 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Taeniopygia guttata
xref: Reactome:REACT_109788 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Rattus norvegicus
xref: Reactome:REACT_110347 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Gallus gallus
xref: Reactome:REACT_110759 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Mus musculus
xref: Reactome:REACT_1165 ! N-atom dealkylation of caffeine, Homo sapiens
xref: Reactome:REACT_122 ! Dehalogenation of carbon tetrachloride to form a free radical, Homo sapiens
xref: Reactome:REACT_13412 ! CYP2U1 can omega-hydroxylate arachidonate, Homo sapiens
xref: Reactome:REACT_13485 ! CYP4F12 hydroxylates arachidonic acid, Homo sapiens
xref: Reactome:REACT_13515 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Homo sapiens
xref: Reactome:REACT_13607 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Homo sapiens
xref: Reactome:REACT_13614 ! CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Homo sapiens
xref: Reactome:REACT_13615 ! CYP4B1 can 12-hydroxylate arachidonic acid, Homo sapiens
xref: Reactome:REACT_13624 ! CYP4F8 hydroxylates prostaglandin H2, Homo sapiens
xref: Reactome:REACT_13651 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Homo sapiens
xref: Reactome:REACT_13668 ! CYP1B1 4-hydroxylates estradiol-17beta, Homo sapiens
xref: Reactome:REACT_13670 ! CYP3A7 can 6beta-hydroxylate testosterone, Homo sapiens
xref: Reactome:REACT_13671 ! CYP2F1 dehydrogenates 3-methylindole, Homo sapiens
xref: Reactome:REACT_13729 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Homo sapiens
xref: Reactome:REACT_13734 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Homo sapiens
xref: Reactome:REACT_13738 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Homo sapiens
xref: Reactome:REACT_13761 ! CYP2C19 5-hydroxylates omeprazole, Homo sapiens
xref: Reactome:REACT_13765 ! CYP3A4 can N-demethylate loperaminde, Homo sapiens
xref: Reactome:REACT_1437 ! N-hydroxylation of 4-aminobiphenyl, Homo sapiens
xref: Reactome:REACT_1447 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Homo sapiens
xref: Reactome:REACT_163 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Homo sapiens
xref: Reactome:REACT_1750 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Homo sapiens
xref: Reactome:REACT_1995 ! S-atom dealkylation of 6-methylmercaptopurine, Homo sapiens
xref: Reactome:REACT_228 ! Benzene is hydroxylated to phenol, Homo sapiens
xref: Reactome:REACT_28179 ! CYP3A7 can 6beta-hydroxylate testosterone, Rattus norvegicus
xref: Reactome:REACT_28287 ! CYP4B1 can 12-hydroxylate arachidonic acid, Rattus norvegicus
xref: Reactome:REACT_28328 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Caenorhabditis elegans
xref: Reactome:REACT_28569 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Rattus norvegicus
xref: Reactome:REACT_29648 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Danio rerio
xref: Reactome:REACT_30083 ! O-atom dealkylation of dextromethorphan, Taeniopygia guttata
xref: Reactome:REACT_30377 ! CYP4F12 hydroxylates arachidonic acid, Sus scrofa
xref: Reactome:REACT_30413 ! S-atom dealkylation of 6-methylmercaptopurine, Taeniopygia guttata
xref: Reactome:REACT_305 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Homo sapiens
xref: Reactome:REACT_30596 ! N-atom dealkylation of caffeine, Xenopus tropicalis
xref: Reactome:REACT_30757 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Danio rerio
xref: Reactome:REACT_31096 ! CYP3A7 can 6beta-hydroxylate testosterone, Drosophila melanogaster
xref: Reactome:REACT_31117 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Sus scrofa
xref: Reactome:REACT_31583 ! Dehalogenation of carbon tetrachloride to form a free radical, Xenopus tropicalis
xref: Reactome:REACT_323 ! O-atom dealkylation of dextromethorphan, Homo sapiens
xref: Reactome:REACT_32309 ! CYP4A11 omega-hydroxylates laurate, Danio rerio
xref: Reactome:REACT_32803 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Mus musculus
xref: Reactome:REACT_33556 ! CYP2U1 can omega-hydroxylate arachidonate, Bos taurus
xref: Reactome:REACT_33790 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Rattus norvegicus
xref: Reactome:REACT_33813 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Rattus norvegicus
xref: Reactome:REACT_33859 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Sus scrofa
xref: Reactome:REACT_33898 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Mus musculus
xref: Reactome:REACT_33922 ! CYP1B1 4-hydroxylates estradiol-17beta, Xenopus tropicalis
xref: Reactome:REACT_34265 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Danio rerio
xref: Reactome:REACT_34271 ! Benzene is hydroxylated to phenol, Mus musculus
xref: Reactome:REACT_34597 ! Dehalogenation of carbon tetrachloride to form a free radical, Canis familiaris
xref: Reactome:REACT_44575 ! O-atom dealkylation of dextromethorphan, Rattus norvegicus
xref: Reactome:REACT_49029 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Bos taurus
xref: Reactome:REACT_499 ! MEOS oxidizes ethanol to acetaldehyde, Homo sapiens
xref: Reactome:REACT_54494 ! CYP3A4 can N-demethylate loperaminde, Rattus norvegicus
xref: Reactome:REACT_54870 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Bos taurus
xref: Reactome:REACT_55692 ! Benzene is hydroxylated to phenol, Sus scrofa
xref: Reactome:REACT_58290 ! CYP1B1 4-hydroxylates estradiol-17beta, Mus musculus
xref: Reactome:REACT_58734 ! CYP4A11 omega-hydroxylates laurate, Bos taurus
xref: Reactome:REACT_75504 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Bos taurus
xref: Reactome:REACT_77501 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Mus musculus
xref: Reactome:REACT_77895 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Taeniopygia guttata
xref: Reactome:REACT_77958 ! O-atom dealkylation of dextromethorphan, Sus scrofa
xref: Reactome:REACT_78242 ! Dehalogenation of carbon tetrachloride to form a free radical, Bos taurus
xref: Reactome:REACT_78392 ! N-hydroxylation of 4-aminobiphenyl, Canis familiaris
xref: Reactome:REACT_78439 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Mus musculus
xref: Reactome:REACT_79362 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Bos taurus
xref: Reactome:REACT_79520 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Canis familiaris
xref: Reactome:REACT_79814 ! Benzene is hydroxylated to phenol, Rattus norvegicus
xref: Reactome:REACT_80439 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Xenopus tropicalis
xref: Reactome:REACT_80448 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Taeniopygia guttata
xref: Reactome:REACT_80600 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Gallus gallus
xref: Reactome:REACT_80785 ! MEOS oxidizes ethanol to acetaldehyde, Canis familiaris
xref: Reactome:REACT_81228 ! CYP2U1 can omega-hydroxylate arachidonate, Mus musculus
xref: Reactome:REACT_81599 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Canis familiaris
xref: Reactome:REACT_81769 ! S-atom dealkylation of 6-methylmercaptopurine, Canis familiaris
xref: Reactome:REACT_82090 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Gallus gallus
xref: Reactome:REACT_82285 ! CYP3A7 can 6beta-hydroxylate testosterone, Canis familiaris
xref: Reactome:REACT_82546 ! CYP4F8 hydroxylates prostaglandin H2, Xenopus tropicalis
xref: Reactome:REACT_82713 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Gallus gallus
xref: Reactome:REACT_82917 ! CYP4A11 omega-hydroxylates laurate, Sus scrofa
xref: Reactome:REACT_83225 ! CYP1B1 4-hydroxylates estradiol-17beta, Rattus norvegicus
xref: Reactome:REACT_83236 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Danio rerio
xref: Reactome:REACT_83558 ! N-atom dealkylation of caffeine, Canis familiaris
xref: Reactome:REACT_83612 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Bos taurus
xref: Reactome:REACT_83900 ! Dehalogenation of carbon tetrachloride to form a free radical, Rattus norvegicus
xref: Reactome:REACT_83932 ! O-atom dealkylation of dextromethorphan, Xenopus tropicalis
xref: Reactome:REACT_83946 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Bos taurus
xref: Reactome:REACT_83985 ! MEOS oxidizes ethanol to acetaldehyde, Rattus norvegicus
xref: Reactome:REACT_84011 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Bos taurus
xref: Reactome:REACT_84240 ! CYP4A11 omega-hydroxylates laurate, Mus musculus
xref: Reactome:REACT_84540 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Gallus gallus
xref: Reactome:REACT_84651 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Mus musculus
xref: Reactome:REACT_84804 ! CYP4B1 can 12-hydroxylate arachidonic acid, Mus musculus
xref: Reactome:REACT_85142 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Mus musculus
xref: Reactome:REACT_85590 ! CYP4F8 hydroxylates prostaglandin H2, Bos taurus
xref: Reactome:REACT_85617 ! CYP2C19 5-hydroxylates omeprazole, Danio rerio
xref: Reactome:REACT_85789 ! CYP3A7 can 6beta-hydroxylate testosterone, Danio rerio
xref: Reactome:REACT_86584 ! CYP2F1 dehydrogenates 3-methylindole, Canis familiaris
xref: Reactome:REACT_86609 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Danio rerio
xref: Reactome:REACT_87066 ! CYP2U1 can omega-hydroxylate arachidonate, Xenopus tropicalis
xref: Reactome:REACT_87157 ! CYP4F8 hydroxylates prostaglandin H2, Canis familiaris
xref: Reactome:REACT_87553 ! CYP1B1 4-hydroxylates estradiol-17beta, Taeniopygia guttata
xref: Reactome:REACT_87557 ! MEOS oxidizes ethanol to acetaldehyde, Taeniopygia guttata
xref: Reactome:REACT_87584 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Canis familiaris
xref: Reactome:REACT_87585 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Mus musculus
xref: Reactome:REACT_88131 ! CYP4B1 can 12-hydroxylate arachidonic acid, Bos taurus
xref: Reactome:REACT_88365 ! S-atom dealkylation of 6-methylmercaptopurine, Xenopus tropicalis
xref: Reactome:REACT_88376 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Rattus norvegicus
xref: Reactome:REACT_88388 ! CYP1B1 4-hydroxylates estradiol-17beta, Sus scrofa
xref: Reactome:REACT_88780 ! N-hydroxylation of 4-aminobiphenyl, Xenopus tropicalis
xref: Reactome:REACT_89077 ! Benzene is hydroxylated to phenol, Bos taurus
xref: Reactome:REACT_89132 ! Ethylene is oxidized to Ethylene oxide by CYP1A1, Xenopus tropicalis
xref: Reactome:REACT_89288 ! MEOS oxidizes ethanol to acetaldehyde, Sus scrofa
xref: Reactome:REACT_89918 ! CYP4A11 omega-hydroxylates laurate, Xenopus tropicalis
xref: Reactome:REACT_90187 ! Cyclophosphamide is 4-hydroxylated by CYP2B6, Bos taurus
xref: Reactome:REACT_90287 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Xenopus tropicalis
xref: Reactome:REACT_90452 ! CYP2C19 5-hydroxylates omeprazole, Taeniopygia guttata
xref: Reactome:REACT_90650 ! N-atom dealkylation of caffeine, Rattus norvegicus
xref: Reactome:REACT_90911 ! CYP4F8 hydroxylates prostaglandin H2, Mus musculus
xref: Reactome:REACT_91080 ! CYP3A4 can N-demethylate loperaminde, Danio rerio
xref: Reactome:REACT_91396 ! CYP3A4 can N-demethylate loperaminde, Bos taurus
xref: Reactome:REACT_91491 ! CYP3A4 can N-demethylate loperaminde, Gallus gallus
xref: Reactome:REACT_91742 ! CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Rattus norvegicus
xref: Reactome:REACT_91815 ! O-atom dealkylation of dextromethorphan, Gallus gallus
xref: Reactome:REACT_92052 ! Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Sus scrofa
xref: Reactome:REACT_92115 ! N-hydroxylation of 4-aminobiphenyl, Sus scrofa
xref: Reactome:REACT_92163 ! CYP4A11 omega-hydroxylates laurate, Gallus gallus
xref: Reactome:REACT_92564 ! O-atom dealkylation of dextromethorphan, Mus musculus
xref: Reactome:REACT_92591 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Xenopus tropicalis
xref: Reactome:REACT_92660 ! CYP3A7 can 6beta-hydroxylate testosterone, Mus musculus
xref: Reactome:REACT_92678 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Taeniopygia guttata
xref: Reactome:REACT_92793 ! CYP2U1 can omega-hydroxylate arachidonate, Sus scrofa
xref: Reactome:REACT_92798 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Bos taurus
xref: Reactome:REACT_92861 ! CYP4F3 omega-hydroxylates leukotriene B4, thus inactivating it, Bos taurus
xref: Reactome:REACT_92887 ! CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it, Sus scrofa
xref: Reactome:REACT_93025 ! CYP3A5 oxidises aflatoxin B1 to aflatoxin-8,9-oxide, Drosophila melanogaster
xref: Reactome:REACT_93071 ! CYP2F1 dehydrogenates 3-methylindole, Rattus norvegicus
xref: Reactome:REACT_93786 ! CYP3A4 can N-demethylate loperaminde, Mus musculus
xref: Reactome:REACT_94199 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Xenopus tropicalis
xref: Reactome:REACT_94252 ! CYP2F1 dehydrogenates 3-methylindole, Mus musculus
xref: Reactome:REACT_94389 ! CYP1B1 4-hydroxylates estradiol-17beta, Gallus gallus
xref: Reactome:REACT_95074 ! CYP2U1 can omega-hydroxylate arachidonate, Danio rerio
xref: Reactome:REACT_95175 ! CYP4B1 can 12-hydroxylate arachidonic acid, Canis familiaris
xref: Reactome:REACT_95629 ! CYP2F1 dehydrogenates 3-methylindole, Xenopus tropicalis
xref: Reactome:REACT_95768 ! CYP4F8 hydroxylates prostaglandin H2, Taeniopygia guttata
xref: Reactome:REACT_95891 ! O-atom dealkylation of dextromethorphan, Canis familiaris
xref: Reactome:REACT_96007 ! CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation, Danio rerio
xref: Reactome:REACT_96630 ! O-atom dealkylation of dextromethorphan, Bos taurus
xref: Reactome:REACT_97001 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Canis familiaris
xref: Reactome:REACT_97031 ! S-atom dealkylation of 6-methylmercaptopurine, Mus musculus
xref: Reactome:REACT_97585 ! Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide, Xenopus tropicalis
xref: Reactome:REACT_97637 ! CYP2C19 5-hydroxylates omeprazole, Xenopus tropicalis
xref: Reactome:REACT_97724 ! S-atom dealkylation of 6-methylmercaptopurine, Bos taurus
xref: Reactome:REACT_97732 ! Benzene is hydroxylated to phenol, Danio rerio
xref: Reactome:REACT_97964 ! CYP4F12 hydroxylates arachidonic acid, Xenopus tropicalis
xref: Reactome:REACT_97980 ! CYP4F12 hydroxylates arachidonic acid, Danio rerio
xref: Reactome:REACT_98 ! CYP4A11 omega-hydroxylates laurate, Homo sapiens
xref: Reactome:REACT_98236 ! CYP1B1 4-hydroxylates estradiol-17beta, Bos taurus
xref: Reactome:REACT_98427 ! CYP2C19 5-hydroxylates omeprazole, Bos taurus
xref: Reactome:REACT_98611 ! CYP3A4 can N-demethylate loperaminde, Canis familiaris
xref: Reactome:REACT_98613 ! CYP2U1 can omega-hydroxylate arachidonate, Caenorhabditis elegans
xref: Reactome:REACT_98733 ! CYP4F12 hydroxylates arachidonic acid, Canis familiaris
xref: Reactome:REACT_98774 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Sus scrofa
xref: Reactome:REACT_98874 ! MEOS oxidizes ethanol to acetaldehyde, Mus musculus
xref: Reactome:REACT_98906 ! S-atom dealkylation of 6-methylmercaptopurine, Rattus norvegicus
xref: Reactome:REACT_98989 ! CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation, Gallus gallus
xref: Reactome:REACT_99056 ! CYP3A7 can 6beta-hydroxylate testosterone, Gallus gallus
xref: Reactome:REACT_99083 ! CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation, Rattus norvegicus
xref: Reactome:REACT_99093 ! Dehalogenation of carbon tetrachloride to form a free radical, Gallus gallus
xref: Reactome:REACT_99244 ! Vinyl chloride is oxidized to 2-Chloroethylene oxide, Taeniopygia guttata
xref: Reactome:REACT_99362 ! Dehalogenation of carbon tetrachloride to form a free radical, Taeniopygia guttata
xref: Reactome:REACT_99726 ! CYP4A11 omega-hydroxylates laurate, Canis familiaris
is_a: GO:0005488 ! binding

[Term]
id: GO:0019840
name: isoprenoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0019842
name: vitamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0019861
name: flagellum
namespace: cellular_component
alt_id: GO:0008223
def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [SP_KW:KW-0282]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flagellum
is_a: GO:0043229 ! intracellular organelle
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0020015
name: glycosome
namespace: cellular_component
def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb]
subset: goslim_pir
xref: Wikipedia:Glycosome
is_a: GO:0042579 ! microbody

[Term]
id: GO:0020022
name: acidocalcisome
namespace: cellular_component
def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb]
subset: goslim_pir
synonym: "metachromatic granule" EXACT [PMID:15738951]
synonym: "polyphosphate vacuole" RELATED [PMID:15738951]
synonym: "volutin granule" EXACT [PMID:15738951]
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure disassembly" EXACT []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure assembly" EXACT []
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0022610
name: biological adhesion
namespace: biological_process
def: "The attachment of a cell or organism to a substrate or other organism." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]
subset: goslim_pir
subset: gosubset_prok
synonym: "antenna complex" RELATED []
xref: Wikipedia:Light-harvesting_complex
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030112
name: glycocalyx
namespace: cellular_component
def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Glycocalyx
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030115
name: S-layer
namespace: cellular_component
def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:S-layer
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030119
name: AP-type membrane coat adaptor complex
namespace: cellular_component
def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]
subset: goslim_pir
synonym: "clathrin adaptor" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0043234 ! protein complex
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0030175
name: filopodium
namespace: cellular_component
alt_id: GO:0030028
def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "microspike" EXACT []
xref: NIF_Subcellular:sao-1046371754
xref: Wikipedia:Filopodia
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
relationship: part_of GO:0065007 ! biological regulation
relationship: regulates GO:0003824 ! catalytic activity
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "selectin" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0044464 ! cell part

[Term]
id: GO:0030313
name: cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_envelope
is_a: GO:0044464 ! cell part
relationship: has_part GO:0016020 ! membrane

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: goslim_pir
subset: gosubset_prok
synonym: "cross wall" EXACT []
synonym: "septum" BROAD []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030431
name: sleep
namespace: biological_process
def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
subset: goslim_pir
synonym: "diapause" RELATED []
synonym: "dormancy" RELATED []
synonym: "lethargus" RELATED []
xref: Wikipedia:Sleep
is_a: GO:0050896 ! response to stimulus
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0030496
name: midbody
namespace: cellular_component
def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Midbody_(cell_biology)
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030529
name: ribonucleoprotein complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
subset: goslim_pir
subset: gosubset_prok
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
synonym: "protein-RNA complex" EXACT []
synonym: "ribonucleoprotein" EXACT []
xref: Wikipedia:Ribonucleoprotein
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: goslim_pir
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
xref: Wikipedia:SnRNP
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus
is_a: GO:0005575 ! cellular_component
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
subset: goslim_pir
subset: gosubset_prok
synonym: "RNase P complex" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030684
name: preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]
subset: goslim_pir
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030689
name: Noc complex
namespace: cellular_component
def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]
comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "multisubunit RNA polymerase" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030894
name: replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]
subset: goslim_pir
subset: gosubset_prok
synonym: "DNA synthesome complex" RELATED [CORUM:1001]
synonym: "RC complex" RELATED [CORUM:309, PMID:12006500]
synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500]
xref: Wikipedia:Replisome
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0030904
name: retromer complex
namespace: cellular_component
def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030964
name: NADH dehydrogenase complex
namespace: cellular_component
alt_id: GO:0030025
alt_id: GO:0030966
alt_id: GO:0031675
alt_id: GO:0031677
alt_id: GO:0031678
alt_id: GO:0045280
def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
subset: goslim_pir
subset: gosubset_prok
synonym: "Complex I" EXACT []
synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW []
synonym: "NADH dehydrogenase complex (quinone)" NARROW []
synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW []
synonym: "NADH:plastoquinone reductase complex" NARROW []
synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW []
xref: Wikipedia:NADH_dehydrogenase
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0030990
name: intraflagellar transport particle
namespace: cellular_component
def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kmv, PMID:14570576]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0042995 ! cell projection
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Extracellular_matrix
relationship: part_of GO:0005576 ! extracellular region
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031023
name: microtubule organizing center organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "microtubule organising center organisation" EXACT [GOC:curators]
synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0006996 ! organelle organization

[Term]
id: GO:0031026
name: glutamate synthase complex
namespace: cellular_component
def: "A complex that possesses glutamate synthase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031049
name: programmed DNA elimination
namespace: biological_process
def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0031074
name: nucleocytoplasmic shuttling complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031082
name: BLOC complex
namespace: cellular_component
def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031094
name: platelet dense tubular network
namespace: cellular_component
def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0031105
name: septin complex
namespace: cellular_component
def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732]
subset: goslim_pir
synonym: "pseudopod" EXACT []
xref: Wikipedia:Pseudopod
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031205
name: endoplasmic reticulum Sec complex
namespace: cellular_component
def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809]
subset: goslim_pir
relationship: has_part GO:0005784 ! Sec61 translocon complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0031248
name: protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031254
name: trailing edge
namespace: cellular_component
def: "The area of a motile cell opposite to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "back of cell" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031264
name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
subset: goslim_pir
synonym: "DISC" EXACT []
synonym: "death-inducing signalling complex" EXACT []
xref: Wikipedia:Death-inducing_signaling_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0031332
name: RNAi effector complex
namespace: cellular_component
def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433]
subset: goslim_pir
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0031371
name: ubiquitin conjugating enzyme complex
namespace: cellular_component
def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]
subset: goslim_pir
synonym: "E2 complex" RELATED []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031386
name: protein tag
namespace: molecular_function
def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]
subset: goslim_pir
synonym: "covalent modifier" RELATED [GOC:vw]
synonym: "protein tagging activity" RELATED []
synonym: "ubiquitin" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0031406
name: carboxylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0031409
name: pigment binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0031469
name: polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0031501
name: mannosyltransferase complex
namespace: cellular_component
def: "A complex that posseses mannosyltransferase activity." [GOC:mah]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031519
name: PcG protein complex
namespace: cellular_component
def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
subset: goslim_pir
synonym: "Polycomb Group protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0031640
name: killing of cells of other organism
namespace: biological_process
alt_id: GO:0001908
def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "killing of cells of another organism" EXACT [GOC:bf]
synonym: "killing of cells of another, non-host, organism" NARROW []
is_a: GO:0001906 ! cell killing
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0031647
name: regulation of protein stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0065007 ! biological regulation
relationship: regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043226 ! organelle

[Term]
id: GO:0031992
name: energy transducer activity
namespace: molecular_function
def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators]
subset: goslim_pir
synonym: "light harvesting activity" RELATED []
synonym: "photon capture" RELATED []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291]
subset: goslim_pir
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0032153
name: cell division site
namespace: cellular_component
def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, GOC:ns, PMID:12101122, PMID:15380095]
comment: Note that this term refers to the future site of division in a cell that has not yet divided.
subset: goslim_pir
synonym: "cell division plane" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
subset: goslim_pir
xref: Wikipedia:Germ_tube
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Transposon
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0032300
name: mismatch repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032392
name: DNA geometric change
namespace: biological_process
def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah]
comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo.
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0032421
name: stereocilium bundle
namespace: cellular_component
def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137]
subset: goslim_pir
synonym: "stereocilia bundle" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0032451
name: demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah]
subset: goslim_pir
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0032476
name: decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "development" NARROW []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032989
name: cellular component morphogenesis
namespace: biological_process
def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular structure morphogenesis" EXACT [GOC:tb, GOC:dph]
relationship: part_of GO:0032502 ! developmental process
is_a: GO:0032502 ! developmental process
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0032991
name: macromolecular complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex" EXACT []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0032997
name: Fc receptor complex
namespace: cellular_component
def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149]
subset: goslim_pir
synonym: "Fc-receptor complex" EXACT []
synonym: "FcR complex" EXACT []
synonym: "immunoglobulin receptor complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0033061
name: DNA recombinase mediator complex
namespace: cellular_component
def: "A protein complex that promotes nucleoprotein filament formation during homologous recombination; most known examples contain two or more RecA family proteins (often Rad51 paralogs)." [GOC:elh, GOC:mah, GOC:vw]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0033099
name: attachment organelle
namespace: cellular_component
def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0033202
name: DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses DNA helicase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0033218
name: amide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988, GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0033256
name: I-kappaB/NF-kappaB complex
namespace: cellular_component
def: "A protein complex containing an I-kappaB protein and one or more copies of an NF-kappaB protein; mediates regulation of NF-kappaB activity by I-kappaB." [GOC:mah, PMID:9407099]
subset: goslim_pir
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0034622
name: cellular macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular macromolecule complex assembly" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0065003 ! macromolecular complex assembly

[Term]
id: GO:0035097
name: histone methyltransferase complex
namespace: cellular_component
def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0035230
name: cytoneme
namespace: cellular_component
def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901]
subset: goslim_pir
synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0035273
name: phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0040007
name: growth
namespace: biological_process
alt_id: GO:0048590
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "growth pattern" RELATED []
synonym: "non-developmental growth" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042044
name: fluid transport
namespace: biological_process
def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042056
name: chemoattractant activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "attractant" BROAD []
relationship: part_of GO:0040011 ! locomotion
relationship: part_of GO:0050896 ! response to stimulus
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0042133
name: neurotransmitter metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]
subset: goslim_pir
synonym: "neurotransmitter metabolism" EXACT []
xref: Reactome:REACT_100207 ! Metabolism of Noradrenaline, Danio rerio
xref: Reactome:REACT_101077 ! Metabolism of Noradrenaline, Taeniopygia guttata
xref: Reactome:REACT_103666 ! Metabolism of Noradrenaline, Rattus norvegicus
xref: Reactome:REACT_104729 ! Metabolism of Noradrenaline, Xenopus tropicalis
xref: Reactome:REACT_108898 ! Metabolism of Noradrenaline, Canis familiaris
xref: Reactome:REACT_15390 ! Metabolism of Noradrenaline, Homo sapiens
xref: Reactome:REACT_57518 ! Metabolism of Noradrenaline, Gallus gallus
xref: Reactome:REACT_87838 ! Metabolism of Noradrenaline, Bos taurus
xref: Reactome:REACT_90506 ! Metabolism of Noradrenaline, Mycobacterium tuberculosis
xref: Reactome:REACT_94583 ! Metabolism of Noradrenaline, Sus scrofa
xref: Reactome:REACT_99002 ! Metabolism of Noradrenaline, Mus musculus
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0065007 ! biological regulation
relationship: part_of GO:0007154 ! cell communication
relationship: part_of GO:0008150 ! biological_process
relationship: part_of GO:0050877 ! neurological system process

[Term]
id: GO:0042165
name: neurotransmitter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042180
name: cellular ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
subset: gosubset_prok
synonym: "ketone metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "ribosomal chaperone activity" RELATED []
synonym: "ribosome biogenesis and assembly" EXACT []
xref: Wikipedia:Ribosome_biogenesis
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0042277
name: peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0042303
name: molting cycle
namespace: biological_process
def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0042440
name: pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "pigment metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042445
name: hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "hormone metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0042562
name: hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]
subset: goslim_pir
xref: Wikipedia:Hydrogenosome
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042579
name: microbody
namespace: cellular_component
def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]
subset: goslim_pir
xref: Wikipedia:Microbody
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042597
name: periplasmic space
namespace: cellular_component
alt_id: GO:0005620
def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi)." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "periplasm" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042600
name: chorion
namespace: cellular_component
def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]
comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
subset: goslim_pir
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0042620
name: poly(3-hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: goslim_pir
subset: gosubset_prok
synonym: "PHA metabolic process" BROAD []
synonym: "PHA metabolism" BROAD []
synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0042810
name: pheromone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "pheromone metabolism" EXACT []
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005783 ! endoplasmic reticulum

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042908
name: xenobiotic transport
namespace: biological_process
def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT []
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao-867568886
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0043021
name: ribonucleoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "RNP binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body

[Term]
id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]
subset: goslim_pir
subset: gosubset_prok
synonym: "debranching enzyme complex" BROAD []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "extracellular structure organisation" EXACT [GOC:curators]
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:mah, GOC:jl, GOC:dph]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0043094
name: cellular metabolic compound salvage
namespace: biological_process
def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043101
name: purine-containing compound salvage
namespace: biological_process
def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [CHEBI:26401, GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "purine salvage" RELATED [GOC:curators]
xref: Reactome:REACT_101336 ! Purine salvage, Schizosaccharomyces pombe
xref: Reactome:REACT_101369 ! Purine salvage, Danio rerio
xref: Reactome:REACT_103029 ! Purine salvage, Sus scrofa
xref: Reactome:REACT_103526 ! Purine salvage, Plasmodium falciparum
xref: Reactome:REACT_104777 ! Purine salvage, Bos taurus
xref: Reactome:REACT_108943 ! Purine salvage, Saccharomyces cerevisiae
xref: Reactome:REACT_109288 ! Purine salvage, Drosophila melanogaster
xref: Reactome:REACT_1923 ! Purine salvage, Homo sapiens
xref: Reactome:REACT_28109 ! Purine salvage, Dictyostelium discoideum
xref: Reactome:REACT_28847 ! Purine salvage, Escherichia coli
xref: Reactome:REACT_31632 ! Purine salvage, Arabidopsis thaliana
xref: Reactome:REACT_32479 ! Purine salvage, Staphylococcus aureus N315
xref: Reactome:REACT_78176 ! Purine salvage, Oryza sativa
xref: Reactome:REACT_79232 ! Purine salvage, Xenopus tropicalis
xref: Reactome:REACT_82121 ! Purine salvage, Gallus gallus
xref: Reactome:REACT_82482 ! Purine salvage, Taeniopygia guttata
xref: Reactome:REACT_84877 ! Purine salvage, Mus musculus
xref: Reactome:REACT_91689 ! Purine salvage, Rattus norvegicus
xref: Reactome:REACT_92683 ! Purine salvage, Mycobacterium tuberculosis
xref: Reactome:REACT_96464 ! Purine salvage, Canis familiaris
xref: Reactome:REACT_99628 ! Purine salvage, Caenorhabditis elegans
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043163
name: cell envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell envelope organisation" EXACT [GOC:curators]
synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "atom binding" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0043283
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0043176
name: amine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043178
name: alcohol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
alt_id: GO:0043191
alt_id: GO:0043192
def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
subset: goslim_pir
subset: gosubset_prok
synonym: "ABC-type efflux permease complex" NARROW []
synonym: "ABC-type efflux porter complex" NARROW []
synonym: "ABC-type uptake permease complex" NARROW []
synonym: "ATP-binding cassette (ABC) transporter complex" RELATED []
synonym: "mating pheromone exporter" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043226 ! organelle
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005576 ! extracellular region
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043234
name: protein complex
namespace: cellular_component
def: "Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-protein complex" EXACT []
xref: Wikipedia:Protein_complex
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043256
name: laminin complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]
subset: goslim_pir
is_a: GO:0005575 ! cellular_component
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0043364
name: catalysis of free radical formation
namespace: molecular_function
def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl]
subset: goslim_pir
synonym: "catalysis of free radical generation" EXACT []
synonym: "catalysis of free-radical biosynthesis" EXACT []
synonym: "catalysis of free-radical formation" EXACT []
synonym: "catalysis of free-radical generation" EXACT []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0043412
name: macromolecule modification
namespace: biological_process
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043446
name: cellular alkane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkane metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043449
name: cellular alkene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkene metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043452
name: cellular alkyne metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkyne metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in an organism, tissue or cell." [GOC:jl]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0043498
name: cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0043511
name: inhibin complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
subset: goslim_pir
relationship: part_of GO:0005576 ! extracellular region
is_a: GO:0005575 ! cellular_component
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
alt_id: GO:0055030
def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041]
subset: goslim_pir
synonym: "endospore wall" EXACT [GOC:mah]
synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu]
synonym: "spore wall" BROAD [GOC:mtg_sensu]
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0043603
name: cellular amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [CHEBI:32988]
subset: goslim_pir
subset: gosubset_prok
synonym: "amide metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_a: GO:0008152 ! metabolic process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]
subset: goslim_pir
subset: gosubset_prok
synonym: "primary metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044255
name: cellular lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular lipid metabolism" EXACT []
xref: Reactome:REACT_100469 ! Fatty acid, triacylglycerol, and ketone body metabolism, Rattus norvegicus
xref: Reactome:REACT_101288 ! Peroxisomal lipid metabolism, Bos taurus
xref: Reactome:REACT_101329 ! Fatty acid, triacylglycerol, and ketone body metabolism, Mus musculus
xref: Reactome:REACT_102412 ! Fatty acid, triacylglycerol, and ketone body metabolism, Canis familiaris
xref: Reactome:REACT_104402 ! Fatty acid, triacylglycerol, and ketone body metabolism, Dictyostelium discoideum
xref: Reactome:REACT_106581 ! Peroxisomal lipid metabolism, Rattus norvegicus
xref: Reactome:REACT_106990 ! Fatty acid, triacylglycerol, and ketone body metabolism, Xenopus tropicalis
xref: Reactome:REACT_107435 ! Peroxisomal lipid metabolism, Danio rerio
xref: Reactome:REACT_108484 ! Peroxisomal lipid metabolism, Dictyostelium discoideum
xref: Reactome:REACT_16957 ! Peroxisomal lipid metabolism, Homo sapiens
xref: Reactome:REACT_22279 ! Fatty acid, triacylglycerol, and ketone body metabolism, Homo sapiens
xref: Reactome:REACT_28392 ! Fatty acid, triacylglycerol, and ketone body metabolism, Arabidopsis thaliana
xref: Reactome:REACT_28564 ! Peroxisomal lipid metabolism, Canis familiaris
xref: Reactome:REACT_28948 ! Peroxisomal lipid metabolism, Mus musculus
xref: Reactome:REACT_29328 ! Fatty acid, triacylglycerol, and ketone body metabolism, Mycobacterium tuberculosis
xref: Reactome:REACT_31891 ! Fatty acid, triacylglycerol, and ketone body metabolism, Caenorhabditis elegans
xref: Reactome:REACT_32011 ! Fatty acid, triacylglycerol, and ketone body metabolism, Danio rerio
xref: Reactome:REACT_32998 ! Peroxisomal lipid metabolism, Schizosaccharomyces pombe
xref: Reactome:REACT_34149 ! Fatty acid, triacylglycerol, and ketone body metabolism, Taeniopygia guttata
xref: Reactome:REACT_79191 ! Peroxisomal lipid metabolism, Drosophila melanogaster
xref: Reactome:REACT_79497 ! Peroxisomal lipid metabolism, Taeniopygia guttata
xref: Reactome:REACT_81034 ! Peroxisomal lipid metabolism, Gallus gallus
xref: Reactome:REACT_81319 ! Peroxisomal lipid metabolism, Arabidopsis thaliana
xref: Reactome:REACT_82818 ! Peroxisomal lipid metabolism, Caenorhabditis elegans
xref: Reactome:REACT_84205 ! Fatty acid, triacylglycerol, and ketone body metabolism, Gallus gallus
xref: Reactome:REACT_84404 ! Peroxisomal lipid metabolism, Mycobacterium tuberculosis
xref: Reactome:REACT_86890 ! Fatty acid, triacylglycerol, and ketone body metabolism, Staphylococcus aureus N315
xref: Reactome:REACT_87163 ! Peroxisomal lipid metabolism, Staphylococcus aureus N315
xref: Reactome:REACT_87905 ! Fatty acid, triacylglycerol, and ketone body metabolism, Drosophila melanogaster
xref: Reactome:REACT_90141 ! Fatty acid, triacylglycerol, and ketone body metabolism, Plasmodium falciparum
xref: Reactome:REACT_92117 ! Peroxisomal lipid metabolism, Escherichia coli
xref: Reactome:REACT_93461 ! Fatty acid, triacylglycerol, and ketone body metabolism, Bos taurus
xref: Reactome:REACT_94266 ! Fatty acid, triacylglycerol, and ketone body metabolism, Sus scrofa
xref: Reactome:REACT_94360 ! Peroxisomal lipid metabolism, Saccharomyces cerevisiae
xref: Reactome:REACT_96855 ! Fatty acid, triacylglycerol, and ketone body metabolism, Escherichia coli
xref: Reactome:REACT_97999 ! Fatty acid, triacylglycerol, and ketone body metabolism, Schizosaccharomyces pombe
xref: Reactome:REACT_98520 ! Peroxisomal lipid metabolism, Oryza sativa
xref: Reactome:REACT_98981 ! Fatty acid, triacylglycerol, and ketone body metabolism, Saccharomyces cerevisiae
xref: Reactome:REACT_99720 ! Fatty acid, triacylglycerol, and ketone body metabolism, Oryza sativa
xref: Reactome:REACT_99861 ! Peroxisomal lipid metabolism, Xenopus tropicalis
xref: Reactome:REACT_99881 ! Peroxisomal lipid metabolism, Sus scrofa
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "cell soma" EXACT []
is_a: GO:0044464 ! cell part
created_by: jane
creation_date: 2010-02-05T10:37:16Z

[Term]
id: GO:0044419
name: interspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044464
name: cell part
namespace: cellular_component
def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "protoplast" RELATED [GOC:mah]
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045178
name: basal part of cell
namespace: cellular_component
def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "translation factor activity" EXACT []
relationship: part_of GO:0065007 ! biological regulation
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]
subset: goslim_pir
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "external encapsulating structure organisation" EXACT [GOC:curators]
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:mah, GOC:jl, GOC:dph]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0045230
name: capsule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "capsule organisation" EXACT [GOC:curators]
synonym: "capsule organization and biogenesis" RELATED []
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045231
name: slime layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "slime layer organisation" EXACT [GOC:curators]
synonym: "slime layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045239
name: tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "TCA cycle enzyme complex" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoyl dehydrogenase complex" BROAD []
synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT []
xref: Wikipedia:Pyruvate_dehydrogenase_complex
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045273
name: respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "electron transport complex II" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
alt_id: GO:0032842
alt_id: GO:0045285
def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733]
subset: goslim_pir
subset: gosubset_prok
synonym: "complex III" EXACT []
synonym: "cytochrome bc(1) complex" EXACT []
synonym: "cytochrome bc1 complex" EXACT []
synonym: "electron transport complex III" RELATED []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT []
synonym: "ubiquinol-cytochrome-c reductase complex" EXACT []
xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045287
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytochrome c oxidase complex" EXACT []
synonym: "electron transport complex IV" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607]
subset: goslim_pir
synonym: "editosome" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0008152 ! metabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0045478
name: fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "fusome organisation" EXACT [GOC:curators]
synonym: "fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0045499
name: chemorepellent activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "chemorepellant activity" EXACT []
relationship: part_of GO:0040011 ! locomotion
relationship: part_of GO:0050896 ! response to stimulus
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045735
name: nutrient reservoir activity
namespace: molecular_function
def: "Functions in the storage of nutritious substrates." [GOC:ai]
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.
subset: goslim_pir
subset: gosubset_prok
synonym: "storage protein" RELATED []
synonym: "storage protein of fat body" RELATED []
synonym: "yolk protein" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0046483
name: heterocycle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "heterocycle metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0046490
name: isopentenyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "IPP metabolic process" EXACT []
synonym: "IPP metabolism" EXACT []
synonym: "isopentenyl diphosphate metabolism" EXACT []
synonym: "isopentenyl pyrophosphate metabolic process" EXACT []
synonym: "isopentenyl pyrophosphate metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0046536
name: dosage compensation complex
namespace: cellular_component
def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah]
subset: goslim_pir
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0046794
name: virion transport
namespace: biological_process
def: "The directed movement of a virion into, out of, or within a host cell." [GOC:ai]
subset: goslim_pir
relationship: part_of GO:0000003 ! reproduction
relationship: part_of GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0016032 ! viral reproduction
is_a: GO:0006810 ! transport
is_a: GO:0044419 ! interspecies interaction between organisms
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0046812
name: host cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the surface of a host cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046864
name: isoprenoid transport
namespace: biological_process
def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai]
subset: goslim_pir
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell, a group of cells, or a tissue." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0046906
name: tetrapyrrole binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [CHEBI:26932, GOC:curators, ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "porphyrin binding" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0046950
name: cellular ketone body metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
synonym: "ketone body metabolism" EXACT []
xref: Reactome:REACT_100444 ! Ketone body metabolism, Caenorhabditis elegans
xref: Reactome:REACT_101523 ! Ketone body metabolism, Danio rerio
xref: Reactome:REACT_109409 ! Ketone body metabolism, Mus musculus
xref: Reactome:REACT_109752 ! Ketone body metabolism, Mycobacterium tuberculosis
xref: Reactome:REACT_110395 ! Ketone body metabolism, Oryza sativa
xref: Reactome:REACT_110725 ! Ketone body metabolism, Xenopus tropicalis
xref: Reactome:REACT_110872 ! Ketone body metabolism, Bos taurus
xref: Reactome:REACT_1861 ! Ketone body metabolism, Homo sapiens
xref: Reactome:REACT_29105 ! Ketone body metabolism, Gallus gallus
xref: Reactome:REACT_29141 ! Ketone body metabolism, Taeniopygia guttata
xref: Reactome:REACT_29697 ! Ketone body metabolism, Canis familiaris
xref: Reactome:REACT_31341 ! Ketone body metabolism, Plasmodium falciparum
xref: Reactome:REACT_34650 ! Ketone body metabolism, Schizosaccharomyces pombe
xref: Reactome:REACT_77702 ! Ketone body metabolism, Saccharomyces cerevisiae
xref: Reactome:REACT_78769 ! Ketone body metabolism, Arabidopsis thaliana
xref: Reactome:REACT_80825 ! Ketone body metabolism, Drosophila melanogaster
xref: Reactome:REACT_84796 ! Ketone body metabolism, Sus scrofa
xref: Reactome:REACT_85192 ! Ketone body metabolism, Dictyostelium discoideum
xref: Reactome:REACT_89476 ! Ketone body metabolism, Escherichia coli
xref: Reactome:REACT_90520 ! Ketone body metabolism, Rattus norvegicus
xref: Reactome:REACT_95478 ! Ketone body metabolism, Staphylococcus aureus N315
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0048037
name: cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0048180
name: activin complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
subset: goslim_pir
relationship: part_of GO:0005576 ! extracellular region
is_a: GO:0005575 ! cellular_component
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0048196
name: middle lamella-containing extracellular matrix
namespace: cellular_component
def: "The matrix external to the cell, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466]
comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
subset: goslim_pir
is_a: GO:0031012 ! extracellular matrix
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid]
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0032502 ! developmental process
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0032502 ! developmental process
relationship: part_of GO:0009987 ! cellular process

[Term]
id: GO:0048476
name: Holliday junction resolvase complex
namespace: cellular_component
def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758]
subset: goslim_pir
synonym: "Mus81-Eme1 complex" NARROW []
synonym: "resolvasome" EXACT [PMID:11207366]
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0048492
name: ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
synonym: "RubisCO complex" EXACT []
relationship: part_of GO:0005622 ! intracellular
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0048500
name: signal recognition particle
namespace: cellular_component
def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Signal_recognition_particle
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0048511
name: rhythmic process
namespace: biological_process
def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid]
subset: goslim_pir
subset: gosubset_prok
synonym: "rhythm" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT [GOC:curators]
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0043473 ! pigmentation
relationship: part_of GO:0009987 ! cellular process

[Term]
id: GO:0048771
name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050761
name: depsipeptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "depsipeptide metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050817
name: coagulation
namespace: biological_process
def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]
subset: goslim_pir
synonym: "clotting" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050824
name: water binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with water (H2O)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0050840
name: extracellular matrix binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "extracellular matrix constituent binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050877
name: neurological system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_generic
subset: goslim_pir
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC.
subset: goslim_pir
subset: gosubset_prok
subset: high_level_annotation_qc
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051179
name: localization
namespace: biological_process
def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
synonym: "localisation" EXACT [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051180
name: vitamin transport
namespace: biological_process
def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0051181
name: cofactor transport
namespace: biological_process
def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0051186
name: cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cofactor metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0051189
name: prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "prosthetic group metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process
relationship: part_of GO:0019538 ! protein metabolic process
relationship: part_of GO:0044237 ! cellular metabolic process

[Term]
id: GO:0051213
name: dioxygenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment of localisation" EXACT [GOC:mah]
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0051179 ! localization

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0016043 ! cellular component organization
is_a: GO:0034622 ! cellular macromolecular complex assembly

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
alt_id: GO:0007001
alt_id: GO:0051277
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division. Note that there is no relationship between this term and 'nuclear division ; GO:0000280' because cell division can take place without nuclear division (as in prokaryotes) and vice versa (as in syncytium formation by mitosis without cytokinesis.
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_division
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051540
name: metal cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0051604
name: protein maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
relationship: part_of GO:0043170 ! macromolecule metabolic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
synonym: "organelle localisation" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
def: "A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular localisation" EXACT [GOC:mah]
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
is_a: GO:0051179 ! localization
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051703
name: intraspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "intraspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051704
name: multi-organism process
namespace: biological_process
alt_id: GO:0051706
def: "Any process in which an organism has an effect on another organism of the same or different species." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction between organisms" EXACT []
synonym: "physiological interaction between organisms" EXACT []
synonym: "physiological interaction with other organism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051705
name: behavioral interaction between organisms
namespace: biological_process
alt_id: GO:0023032
def: "Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai]
subset: goslim_pir
synonym: "behavioral interaction with other organism" EXACT []
synonym: "behavioral signaling" NARROW []
synonym: "behavioral signalling" NARROW [GOC:mah]
synonym: "behavioural interaction between organisms" EXACT []
synonym: "behavioural interaction with other organism" EXACT []
is_a: GO:0050896 ! response to stimulus
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0052314
name: phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
subset: goslim_pir
subset: gosubset_prok
synonym: "phytoalexin metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0055044
name: symplast
namespace: cellular_component
def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu]
subset: goslim_pir
xref: Wikipedia:Symplast
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT_16mar07]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060090
name: binding, bridging
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07]
subset: goslim_pir
subset: gosubset_prok
synonym: "molecular adaptor activity" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0065003
name: macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any biological process, quality or function." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0070020
name: transforming growth factor beta1-type II receptor complex
namespace: cellular_component
def: "A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:REACT_7218]
subset: goslim_pir
synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:REACT_7218]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0070021
name: transforming growth factor beta1-type II receptor-type I receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer." [Reactome:REACT_7425]
subset: goslim_pir
synonym: "TGF-beta 1:type II receptor:type I receptor complex" EXACT [Reactome:REACT_7425]
synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor-type I receptor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0070023
name: interleukin-12-interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991]
subset: goslim_pir
synonym: "IL12-IL12 receptor complex" EXACT []
synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0070024
name: CD19-Vav-PIK3R1 complex
namespace: cellular_component
def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218]
subset: goslim_pir
synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0070450
name: interleukin4-interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772]
subset: goslim_pir
synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah]
synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0070451
name: cell hair
namespace: cellular_component
def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
subset: goslim_pir
synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah]
synonym: "non-sensory hair" EXACT [GOC:bf]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0070517
name: DNA replication factor C core complex
namespace: cellular_component
def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326]
subset: goslim_pir
synonym: "RFC core complex" EXACT [CORUM:278]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005663 ! DNA replication factor C complex
relationship: part_of GO:0005634 ! nucleus
relationship: part_of GO:0030894 ! replisome

[Term]
id: GO:0070565
name: telomere-telomerase complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
relationship: part_of GO:0043229 ! intracellular organelle
relationship: part_of GO:0005694 ! chromosome
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part
created_by: midori
creation_date: 2009-04-14T03:07:50Z

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "cell wall organisation" EXACT [GOC:curators]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
created_by: midori
creation_date: 2010-01-13T03:33:07Z

[Typedef]
id: has_part
name: has_part
namespace: gene_ontology
xref: OBO_REL:has_part
is_transitive: true
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Typedef]
id: negatively_regulates
name: negatively_regulates
namespace: gene_ontology

[Typedef]
id: occurs_in
name: occurs in
namespace: gene_ontology
xref: BFO:0000066

[Typedef]
id: part_of
name: part_of
namespace: gene_ontology
xref: OBO_REL:part_of
is_transitive: true

[Typedef]
id: positively_regulates
name: positively_regulates
namespace: gene_ontology

[Typedef]
id: regulates
name: regulates
namespace: gene_ontology