format-version: 1.2
date: 15:08:2011 17:04
auto-generated-by: OBO-Edit 2.0
ontology: go
saved-by: kchris
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
subsetdef: high_level_annotation_qc "High-level terms not to be used for direct annotation"
subsetdef: unvetted "unvetted"
remark: cvs version: $Revision: 1.101 $

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai]
comment: Note that most eukaryotic gene products involved in canonical cytokinesis during the cell cycle can be annotated to 'cell cycle cytokinesis ; GO:0033205' or its descendants. See also 'cell division ; GO:0051301'. Note that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division.
subset: goslim_candida
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101918 ! Mitotic Telophase /Cytokinesis, Mus musculus
xref: Reactome:REACT_108805 ! Mitotic Telophase /Cytokinesis, Dictyostelium discoideum
xref: Reactome:REACT_1932 ! Mitotic Telophase /Cytokinesis, Homo sapiens
xref: Reactome:REACT_30667 ! Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe
xref: Reactome:REACT_32636 ! Mitotic Telophase /Cytokinesis, Bos taurus
xref: Reactome:REACT_78494 ! Mitotic Telophase /Cytokinesis, Danio rerio
xref: Reactome:REACT_84722 ! Mitotic Telophase /Cytokinesis, Gallus gallus
xref: Reactome:REACT_87726 ! Mitotic Telophase /Cytokinesis, Xenopus tropicalis
xref: Reactome:REACT_92849 ! Mitotic Telophase /Cytokinesis, Taeniopygia guttata
xref: Reactome:REACT_93374 ! Mitotic Telophase /Cytokinesis, Canis familiaris
xref: Reactome:REACT_94382 ! Mitotic Telophase /Cytokinesis, Drosophila melanogaster
xref: Reactome:REACT_98952 ! Mitotic Telophase /Cytokinesis, Rattus norvegicus
xref: Reactome:REACT_99118 ! Mitotic Telophase /Cytokinesis, Caenorhabditis elegans
xref: Wikipedia:Cytokinesis
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0002193
name: MAML1-RBP-Jkappa- ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]
subset: goslim_candida
synonym: "MAML1-CSL-ICN1" EXACT []
synonym: "MAML1-CSL-Notch1 complex" EXACT []
synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT []
is_a: GO:0005575 ! cellular_component
created_by: hjd
creation_date: 2011-08-11T04:08:18Z

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []
synonym: "molecular function unknown" NARROW []

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: goslim_candida
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
subset: goslim_candida
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101703 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis
xref: Reactome:REACT_103300 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Bos taurus
xref: Reactome:REACT_103323 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum
xref: Reactome:REACT_106430 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus
xref: Reactome:REACT_107757 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster
xref: Reactome:REACT_108232 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa
xref: Reactome:REACT_108368 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae
xref: Reactome:REACT_109723 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana
xref: Reactome:REACT_12458 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens
xref: Reactome:REACT_29965 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris
xref: Reactome:REACT_77167 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus
xref: Reactome:REACT_78197 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa
xref: Reactome:REACT_87164 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe
xref: Reactome:REACT_89329 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus
xref: Reactome:REACT_90531 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio
xref: Reactome:REACT_98683 ! Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_100335 ! RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum
xref: Reactome:REACT_101111 ! Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae
xref: Reactome:REACT_101247 ! Formation of open bubble structure in DNA by helicases, Bos taurus
xref: Reactome:REACT_101622 ! MCM8 mediated fork unwinding, Danio rerio
xref: Reactome:REACT_101644 ! Formation of open bubble structure in DNA by helicases, Oryza sativa
xref: Reactome:REACT_101823 ! MCM2-7 mediated fork unwinding, Plasmodium falciparum
xref: Reactome:REACT_101994 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis
xref: Reactome:REACT_102116 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Bos taurus
xref: Reactome:REACT_102121 ! Addition of the third nucleotide on the nascent transcript, Rattus norvegicus
xref: Reactome:REACT_102441 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus
xref: Reactome:REACT_102560 ! MCM2-7 mediated fork unwinding, Oryza sativa
xref: Reactome:REACT_1033 ! Formation of open bubble structure in DNA by helicases, Homo sapiens
xref: Reactome:REACT_103861 ! MCM8 mediated fork unwinding, Bos taurus
xref: Reactome:REACT_103897 ! MCM8 mediated fork unwinding, Mus musculus
xref: Reactome:REACT_103959 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus
xref: Reactome:REACT_104221 ! MCM2-7 mediated fork unwinding, Rattus norvegicus
xref: Reactome:REACT_105950 ! MCM2-7 mediated fork unwinding, Xenopus tropicalis
xref: Reactome:REACT_106346 ! Formation of open bubble structure in DNA by helicases, Taeniopygia guttata
xref: Reactome:REACT_107072 ! Formation of open bubble structure in DNA by helicases, Mus musculus
xref: Reactome:REACT_107495 ! RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata
xref: Reactome:REACT_108159 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum
xref: Reactome:REACT_108648 ! Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana
xref: Reactome:REACT_108654 ! MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe
xref: Reactome:REACT_109035 ! RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe
xref: Reactome:REACT_109161 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana
xref: Reactome:REACT_110588 ! MCM8 mediated fork unwinding, Xenopus tropicalis
xref: Reactome:REACT_110827 ! Formation of open bubble structure in DNA by helicases, Danio rerio
xref: Reactome:REACT_110838 ! Addition of the third nucleotide on the nascent transcript, Bos taurus
xref: Reactome:REACT_110845 ! Cap-bound mRNA is activated by helicases, Mus musculus
xref: Reactome:REACT_1521 ! Cap-bound mRNA is activated by helicases, Homo sapiens
xref: Reactome:REACT_1817 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens
xref: Reactome:REACT_1844 ! RNA Polymerase II Promoter Opening: First Transition, Homo sapiens
xref: Reactome:REACT_28131 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster
xref: Reactome:REACT_28343 ! MCM2-7 mediated fork unwinding, Danio rerio
xref: Reactome:REACT_28810 ! Addition of the third nucleotide on the nascent transcript, Oryza sativa
xref: Reactome:REACT_28880 ! MCM2-7 mediated fork unwinding, Drosophila melanogaster
xref: Reactome:REACT_29155 ! Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster
xref: Reactome:REACT_29217 ! Formation of open bubble structure in DNA by helicases, Xenopus tropicalis
xref: Reactome:REACT_29818 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa
xref: Reactome:REACT_29850 ! RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae
xref: Reactome:REACT_30013 ! MCM8 mediated fork unwinding, Rattus norvegicus
xref: Reactome:REACT_30989 ! MCM8 mediated fork unwinding, Arabidopsis thaliana
xref: Reactome:REACT_31034 ! Cap-bound mRNA is activated by helicases, Danio rerio
xref: Reactome:REACT_31090 ! MCM2-7 mediated fork unwinding, Gallus gallus
xref: Reactome:REACT_32533 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans
xref: Reactome:REACT_33205 ! MCM8 mediated fork unwinding, Canis familiaris
xref: Reactome:REACT_34016 ! Formation of open bubble structure in DNA by helicases, Rattus norvegicus
xref: Reactome:REACT_34089 ! MCM2-7 mediated fork unwinding, Dictyostelium discoideum
xref: Reactome:REACT_34560 ! MCM8 mediated fork unwinding, Sus scrofa
xref: Reactome:REACT_40 ! Addition of the third nucleotide on the nascent transcript, Homo sapiens
xref: Reactome:REACT_6134 ! HIV-1 Promoter Opening: First Transition, Homo sapiens
xref: Reactome:REACT_6184 ! Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens
xref: Reactome:REACT_6325 ! Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens
xref: Reactome:REACT_6758 ! Xenopus Mcm8 mediated fork unwinding, Xenopus laevis
xref: Reactome:REACT_6768 ! MCM8 mediated fork unwinding, Homo sapiens
xref: Reactome:REACT_6853 ! Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae
xref: Reactome:REACT_6922 ! MCM2-7 mediated fork unwinding, Homo sapiens
xref: Reactome:REACT_78086 ! RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus
xref: Reactome:REACT_78462 ! Formation of open bubble structure in DNA by helicases, Drosophila melanogaster
xref: Reactome:REACT_78667 ! MCM2-7 mediated fork unwinding, Canis familiaris
xref: Reactome:REACT_78771 ! MCM8 mediated fork unwinding, Dictyostelium discoideum
xref: Reactome:REACT_79401 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe
xref: Reactome:REACT_79759 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus
xref: Reactome:REACT_80107 ! RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana
xref: Reactome:REACT_80325 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio
xref: Reactome:REACT_80500 ! MCM8 mediated fork unwinding, Gallus gallus
xref: Reactome:REACT_80532 ! Addition of the third nucleotide on the nascent transcript, Gallus gallus
xref: Reactome:REACT_80605 ! Addition of the third nucleotide on the nascent transcript, Mus musculus
xref: Reactome:REACT_81126 ! Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe
xref: Reactome:REACT_81335 ! RNA Polymerase II Promoter Opening: First Transition, Gallus gallus
xref: Reactome:REACT_81427 ! MCM8 mediated fork unwinding, Taeniopygia guttata
xref: Reactome:REACT_81441 ! MCM8 mediated fork unwinding, Oryza sativa
xref: Reactome:REACT_81682 ! Formation of open bubble structure in DNA by helicases, Canis familiaris
xref: Reactome:REACT_82776 ! RNA Polymerase II Promoter Opening: First Transition, Danio rerio
xref: Reactome:REACT_83794 ! Formation of open bubble structure in DNA by helicases, Gallus gallus
xref: Reactome:REACT_84565 ! Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe
xref: Reactome:REACT_84574 ! Cap-bound mRNA is activated by helicases, Canis familiaris
xref: Reactome:REACT_84809 ! MCM2-7 mediated fork unwinding, Mus musculus
xref: Reactome:REACT_84907 ! MCM2-7 mediated fork unwinding, Taeniopygia guttata
xref: Reactome:REACT_85111 ! Cap-bound mRNA is activated by helicases, Drosophila melanogaster
xref: Reactome:REACT_85172 ! MCM2-7 mediated fork unwinding, Arabidopsis thaliana
xref: Reactome:REACT_86220 ! MCM2-7 mediated fork unwinding, Caenorhabditis elegans
xref: Reactome:REACT_88362 ! Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans
xref: Reactome:REACT_88953 ! Addition of the third nucleotide on the nascent transcript, Canis familiaris
xref: Reactome:REACT_89000 ! MCM2-7 mediated fork unwinding, Bos taurus
xref: Reactome:REACT_89030 ! Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae
xref: Reactome:REACT_89363 ! Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis
xref: Reactome:REACT_89694 ! RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster
xref: Reactome:REACT_91596 ! RNA Polymerase II Promoter Opening: First Transition, Canis familiaris
xref: Reactome:REACT_91692 ! RNA Polymerase II Promoter Opening: First Transition, Bos taurus
xref: Reactome:REACT_91822 ! MCM8 mediated fork unwinding, Plasmodium falciparum
xref: Reactome:REACT_93046 ! Cap-bound mRNA is activated by helicases, Rattus norvegicus
xref: Reactome:REACT_93391 ! RNA Polymerase II Promoter Opening: First Transition, Oryza sativa
xref: Reactome:REACT_93711 ! RNA Polymerase II Promoter Opening: First Transition, Mus musculus
xref: Reactome:REACT_94645 ! RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis
xref: Reactome:REACT_94679 ! RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans
xref: Reactome:REACT_95942 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae
xref: Reactome:REACT_95993 ! Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana
xref: Reactome:REACT_98273 ! Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum
xref: Reactome:REACT_98302 ! Formation of open bubble structure in DNA by helicases, Sus scrofa
xref: Reactome:REACT_98745 ! Cap-bound mRNA is activated by helicases, Xenopus tropicalis
xref: Reactome:REACT_99106 ! Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Canis familiaris
xref: Reactome:REACT_99120 ! Addition of the third nucleotide on the nascent transcript, Danio rerio
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004672
name: protein kinase activity
namespace: molecular_function
alt_id: GO:0050222
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
comment: Note that triphosphate is used as a phosphate donor by at least one kinase.
subset: goslim_candida
subset: gosubset_prok
synonym: "protamine kinase activity" NARROW []
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:REACT_100389 ! Phosphorylation and Release of IRF3 or IRF7, Bos taurus
xref: Reactome:REACT_100723 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Canis familiaris
xref: Reactome:REACT_100866 ! Phosphorylation and activation of Ezrin, Gallus gallus
xref: Reactome:REACT_101171 ! Phosphorylation and release of IRF3/IRF7, Rattus norvegicus
xref: Reactome:REACT_101316 ! Autophosphorylation of FADK1 at Y397, Rattus norvegicus
xref: Reactome:REACT_102340 ! Activated Src activates ERK, Danio rerio
xref: Reactome:REACT_102368 ! Phosphorylation and Release of IRF3 or IRF7, Gallus gallus
xref: Reactome:REACT_104931 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Gallus gallus
xref: Reactome:REACT_104987 ! Phosphorylation of pFADK1 by SRC, Danio rerio
xref: Reactome:REACT_105344 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Sus scrofa
xref: Reactome:REACT_106425 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Taeniopygia guttata
xref: Reactome:REACT_106633 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Sus scrofa
xref: Reactome:REACT_107161 ! Phosphorylation and release of IRF3/IRF7, Taeniopygia guttata
xref: Reactome:REACT_107646 ! Phosphorylation and release of IRF3/IRF7, Canis familiaris
xref: Reactome:REACT_107914 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Xenopus tropicalis
xref: Reactome:REACT_108319 ! Activated Src activates ERK, Xenopus tropicalis
xref: Reactome:REACT_108693 ! Phosphorylation and release of IRF3/IRF7, Mus musculus
xref: Reactome:REACT_109624 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Rattus norvegicus
xref: Reactome:REACT_110105 ! Phosphorylation and activation of Ezrin, Canis familiaris
xref: Reactome:REACT_110177 ! Autophosphorylation of FADK1 at Y397, Mus musculus
xref: Reactome:REACT_110248 ! Activated Src activates ERK, Canis familiaris
xref: Reactome:REACT_12050 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Homo sapiens
xref: Reactome:REACT_1325 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Homo sapiens
xref: Reactome:REACT_15368 ! Phosphorylation of pFADK1 by SRC, Homo sapiens
xref: Reactome:REACT_15375 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Homo sapiens
xref: Reactome:REACT_15534 ! PKC phosphorylates GRK2, Homo sapiens
xref: Reactome:REACT_15535 ! Autophosphorylation of FADK1 at Y397, Homo sapiens
xref: Reactome:REACT_161 ! rLkb-1 (Stk-11) activates AMPK by phosphorylation, Rattus norvegicus
xref: Reactome:REACT_1825 ! INF-gamma induced phosphorylation of L13a, Homo sapiens
xref: Reactome:REACT_19374 ! Phosphorylation of Plexin-A, Mus musculus
xref: Reactome:REACT_22301 ! Phosphorylation and activation of Ezrin, Homo sapiens
xref: Reactome:REACT_22305 ! Phosphorylation of FADK1, Mus musculus
xref: Reactome:REACT_23900 ! Activated Src activates ERK, Homo sapiens
xref: Reactome:REACT_24935 ! Activation of IKK by MEKK1, Homo sapiens
xref: Reactome:REACT_25200 ! IRAK1 phosphorylates Pellino, Homo sapiens
xref: Reactome:REACT_25213 ! Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex, Homo sapiens
xref: Reactome:REACT_25241 ! IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation, Homo sapiens
xref: Reactome:REACT_25327 ! Phosphorylation and release of IRF7, Homo sapiens
xref: Reactome:REACT_25368 ! Phosphorylation and release of IRF3/IRF7, Homo sapiens
xref: Reactome:REACT_27151 ! Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR, Homo sapiens
xref: Reactome:REACT_27163 ! Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex, Homo sapiens
xref: Reactome:REACT_27165 ! Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex, Homo sapiens
xref: Reactome:REACT_27228 ! First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR, Homo sapiens
xref: Reactome:REACT_29590 ! PKC phosphorylates GRK2, Rattus norvegicus
xref: Reactome:REACT_29816 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Drosophila melanogaster
xref: Reactome:REACT_30885 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Bos taurus
xref: Reactome:REACT_31028 ! Autophosphorylation of FADK1 at Y397, Sus scrofa
xref: Reactome:REACT_31157 ! Phosphorylation of pFADK1 by SRC, Canis familiaris
xref: Reactome:REACT_31403 ! Autophosphorylation of FADK1 at Y397, Gallus gallus
xref: Reactome:REACT_32448 ! Phosphorylation of pFADK1 by SRC, Bos taurus
xref: Reactome:REACT_32744 ! PKC phosphorylates GRK2, Mus musculus
xref: Reactome:REACT_33098 ! PKC phosphorylates GRK2, Canis familiaris
xref: Reactome:REACT_33973 ! Phosphorylation and Release of IRF3 or IRF7, Canis familiaris
xref: Reactome:REACT_34630 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Danio rerio
xref: Reactome:REACT_6227 ! Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster
xref: Reactome:REACT_6236 ! Activated DTOR phosphorylates DS6K, Drosophila melanogaster
xref: Reactome:REACT_6842 ! Phosphorylation and Release of IRF3 or IRF7, Homo sapiens
xref: Reactome:REACT_6862 ! Multiple IRAK1 autophosphorylation steps, Chlamydia trachomatis
xref: Reactome:REACT_72123 ! PKC phosphorylates GRK2, Sus scrofa
xref: Reactome:REACT_75763 ! Phosphorylation and release of IRF3, Gallus gallus
xref: Reactome:REACT_75767 ! Phosphorylation of IKKs complex mediated by MEKK1, Gallus gallus
xref: Reactome:REACT_77320 ! Phosphorylation and release of IRF3/IRF7, Gallus gallus
xref: Reactome:REACT_77352 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Danio rerio
xref: Reactome:REACT_78568 ! Phosphorylation and activation of Ezrin, Danio rerio
xref: Reactome:REACT_79546 ! Activated Src activates ERK, Gallus gallus
xref: Reactome:REACT_80082 ! Phosphorylation and release of IRF3/IRF7, Sus scrofa
xref: Reactome:REACT_80382 ! Phosphorylation and activation of Ezrin, Mus musculus
xref: Reactome:REACT_81116 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Canis familiaris
xref: Reactome:REACT_81601 ! Autophosphorylation of FADK1 at Y397, Bos taurus
xref: Reactome:REACT_81960 ! PKC phosphorylates GRK2, Drosophila melanogaster
xref: Reactome:REACT_82440 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Xenopus tropicalis
xref: Reactome:REACT_82942 ! Activated Src activates ERK, Bos taurus
xref: Reactome:REACT_83498 ! Activated Src activates ERK, Taeniopygia guttata
xref: Reactome:REACT_83992 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Mus musculus
xref: Reactome:REACT_84298 ! Autophosphorylation of FADK1 at Y397, Danio rerio
xref: Reactome:REACT_84426 ! Phosphorylation and Release of IRF3 or IRF7, Taeniopygia guttata
xref: Reactome:REACT_85334 ! PKC phosphorylates GRK2, Bos taurus
xref: Reactome:REACT_85508 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Saccharomyces cerevisiae
xref: Reactome:REACT_85934 ! Autophosphorylation of FADK1 at Y397, Canis familiaris
xref: Reactome:REACT_86784 ! Autophosphorylation of FADK1 at Y397, Taeniopygia guttata
xref: Reactome:REACT_86846 ! Activated Src activates ERK, Mus musculus
xref: Reactome:REACT_87050 ! Phosphorylation of pFADK1 by SRC, Mus musculus
xref: Reactome:REACT_87514 ! Phosphorylation and activation of Ezrin, Sus scrofa
xref: Reactome:REACT_87874 ! Phosphorylation of pFADK1 by SRC, Sus scrofa
xref: Reactome:REACT_87926 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Bos taurus
xref: Reactome:REACT_88017 ! PKC phosphorylates GRK2, Taeniopygia guttata
xref: Reactome:REACT_88090 ! Phosphorylation and release of IRF3/IRF7, Bos taurus
xref: Reactome:REACT_88344 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Sus scrofa
xref: Reactome:REACT_88685 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Xenopus tropicalis
xref: Reactome:REACT_89390 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Bos taurus
xref: Reactome:REACT_90060 ! Autophosphorylation of FADK1 at Y397, Xenopus tropicalis
xref: Reactome:REACT_90671 ! Phosphorylation and activation of Ezrin, Xenopus tropicalis
xref: Reactome:REACT_90879 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Gallus gallus
xref: Reactome:REACT_91096 ! Activated Src activates ERK, Sus scrofa
xref: Reactome:REACT_93160 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Mus musculus
xref: Reactome:REACT_93476 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Canis familiaris
xref: Reactome:REACT_93547 ! Activated Src activates ERK, Rattus norvegicus
xref: Reactome:REACT_94091 ! Phosphorylation and activation of Ezrin, Bos taurus
xref: Reactome:REACT_95384 ! Phosphorylation and Release of IRF3 or IRF7, Mus musculus
xref: Reactome:REACT_96044 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Mus musculus
xref: Reactome:REACT_96155 ! Phosphorylation and release of IRF3/IRF7, Danio rerio
xref: Reactome:REACT_96307 ! Phosphorylation and Release of IRF3 or IRF7, Danio rerio
xref: Reactome:REACT_96320 ! Phosphorylation and activation of Ezrin, Rattus norvegicus
xref: Reactome:REACT_96822 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Dictyostelium discoideum
xref: Reactome:REACT_96873 ! LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Caenorhabditis elegans
xref: Reactome:REACT_97267 ! PKC phosphorylates GRK2, Gallus gallus
xref: Reactome:REACT_97501 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Taeniopygia guttata
xref: Reactome:REACT_97784 ! Phosphorylation and activation of Ezrin, Taeniopygia guttata
xref: Reactome:REACT_98334 ! Phosphorylation of pFADK1 by SRC, Rattus norvegicus
xref: Reactome:REACT_98994 ! (Frs2)Rap1-GTP binds to and activates B-Raf, Gallus gallus
xref: Reactome:REACT_99274 ! Phosphorylation of p130Cas by SRC-FADK1 complex, Taeniopygia guttata
is_a: GO:0016740 ! transferase activity
relationship: part_of GO:0006464 ! protein modification process

[Term]
id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
subset: goslim_candida
subset: gosubset_prok
synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16]
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:REACT_100556 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Canis familiaris
xref: Reactome:REACT_101161 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Bos taurus
xref: Reactome:REACT_101258 ! Dephosphorylation of phospho-Cdh1, Taeniopygia guttata
xref: Reactome:REACT_101308 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Mus musculus
xref: Reactome:REACT_101537 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Drosophila melanogaster
xref: Reactome:REACT_102055 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Bos taurus
xref: Reactome:REACT_102521 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Canis familiaris
xref: Reactome:REACT_103107 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Danio rerio
xref: Reactome:REACT_105948 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Rattus norvegicus
xref: Reactome:REACT_106256 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Xenopus tropicalis
xref: Reactome:REACT_107500 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Taeniopygia guttata
xref: Reactome:REACT_107570 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Drosophila melanogaster
xref: Reactome:REACT_107782 ! Pp2a mediated localization of Rb protein in chromatin, Danio rerio
xref: Reactome:REACT_108174 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Gallus gallus
xref: Reactome:REACT_109144 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Drosophila melanogaster
xref: Reactome:REACT_109225 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Rattus norvegicus
xref: Reactome:REACT_109310 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Rattus norvegicus
xref: Reactome:REACT_109345 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Mus musculus
xref: Reactome:REACT_109732 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Rattus norvegicus
xref: Reactome:REACT_110596 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Canis familiaris
xref: Reactome:REACT_1251 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens
xref: Reactome:REACT_28065 ! Pp2a mediated localization of Rb protein in chromatin, Arabidopsis thaliana
xref: Reactome:REACT_28268 ! Dephosphorylation of phospho-Cdh1, Xenopus tropicalis
xref: Reactome:REACT_28473 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Canis familiaris
xref: Reactome:REACT_28474 ! Pp2a mediated localization of Rb protein in chromatin, Canis familiaris
xref: Reactome:REACT_28606 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Gallus gallus
xref: Reactome:REACT_29645 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Mus musculus
xref: Reactome:REACT_30225 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Xenopus tropicalis
xref: Reactome:REACT_33423 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Drosophila melanogaster
xref: Reactome:REACT_421 ! Pp2a mediated localization of Rb protein in chromatin, Homo sapiens
xref: Reactome:REACT_592 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Homo sapiens
xref: Reactome:REACT_59811 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Canis familiaris
xref: Reactome:REACT_6175 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Homo sapiens
xref: Reactome:REACT_6206 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens
xref: Reactome:REACT_6255 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Homo sapiens
xref: Reactome:REACT_6257 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Homo sapiens
xref: Reactome:REACT_6294 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Homo sapiens
xref: Reactome:REACT_6910 ! Dephosphorylation of phospho-Cdh1, Homo sapiens
xref: Reactome:REACT_77578 ! Dephosphorylation of phospho-Cdh1, Rattus norvegicus
xref: Reactome:REACT_77594 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Caenorhabditis elegans
xref: Reactome:REACT_77793 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Danio rerio
xref: Reactome:REACT_78412 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Mus musculus
xref: Reactome:REACT_79518 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Saccharomyces cerevisiae
xref: Reactome:REACT_80229 ! Dephosphorylation of phospho-Cdh1, Bos taurus
xref: Reactome:REACT_80518 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Rattus norvegicus
xref: Reactome:REACT_80852 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Sus scrofa
xref: Reactome:REACT_81016 ! Dephosphorylation of phospho-Cdh1, Sus scrofa
xref: Reactome:REACT_81195 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Xenopus tropicalis
xref: Reactome:REACT_81980 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Bos taurus
xref: Reactome:REACT_82328 ! Dephosphorylation of phospho-Cdh1, Saccharomyces cerevisiae
xref: Reactome:REACT_83073 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Xenopus tropicalis
xref: Reactome:REACT_83503 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Danio rerio
xref: Reactome:REACT_83605 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Dictyostelium discoideum
xref: Reactome:REACT_83812 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Drosophila melanogaster
xref: Reactome:REACT_83901 ! Pp2a mediated localization of Rb protein in chromatin, Gallus gallus
xref: Reactome:REACT_83951 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Bos taurus
xref: Reactome:REACT_84291 ! Pp2a mediated localization of Rb protein in chromatin, Mus musculus
xref: Reactome:REACT_84834 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Danio rerio
xref: Reactome:REACT_84882 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Gallus gallus
xref: Reactome:REACT_86262 ! Dephosphorylation of phospho-Cdh1, Schizosaccharomyces pombe
xref: Reactome:REACT_86293 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Arabidopsis thaliana
xref: Reactome:REACT_86738 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Xenopus tropicalis
xref: Reactome:REACT_88974 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Canis familiaris
xref: Reactome:REACT_89601 ! Dephosphorylation of phospho-Cdh1, Gallus gallus
xref: Reactome:REACT_89607 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Xenopus tropicalis
xref: Reactome:REACT_9062 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Homo sapiens
xref: Reactome:REACT_90978 ! Pp2a mediated localization of Rb protein in chromatin, Taeniopygia guttata
xref: Reactome:REACT_91918 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Danio rerio
xref: Reactome:REACT_91996 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Danio rerio
xref: Reactome:REACT_92030 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Bos taurus
xref: Reactome:REACT_92154 ! Dephosphorylation of phospho-Cdh1, Canis familiaris
xref: Reactome:REACT_92277 ! Pp2a mediated localization of Rb protein in chromatin, Bos taurus
xref: Reactome:REACT_92312 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Bos taurus
xref: Reactome:REACT_92765 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Oryza sativa
xref: Reactome:REACT_93167 ! Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Mus musculus
xref: Reactome:REACT_93324 ! Pp2a mediated localization of Rb protein in chromatin, Dictyostelium discoideum
xref: Reactome:REACT_94004 ! Dephosphorylation of phospho-Cdh1, Danio rerio
xref: Reactome:REACT_95002 ! Pp2a mediated localization of Rb protein in chromatin, Sus scrofa
xref: Reactome:REACT_95049 ! Dephosphorylation of phospho-Cdh1, Mus musculus
xref: Reactome:REACT_95090 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Mus musculus
xref: Reactome:REACT_95610 ! Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Sus scrofa
xref: Reactome:REACT_95688 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Drosophila melanogaster
xref: Reactome:REACT_95930 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Xenopus tropicalis
xref: Reactome:REACT_95992 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Mus musculus
xref: Reactome:REACT_96195 ! Pp2a mediated localization of Rb protein in chromatin, Rattus norvegicus
xref: Reactome:REACT_96431 ! Pp2a mediated localization of Rb protein in chromatin, Oryza sativa
xref: Reactome:REACT_97239 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Canis familiaris
xref: Reactome:REACT_97616 ! Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Taeniopygia guttata
xref: Reactome:REACT_98140 ! Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Bos taurus
xref: Reactome:REACT_98958 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Rattus norvegicus
xref: Reactome:REACT_98967 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Schizosaccharomyces pombe
xref: Reactome:REACT_99508 ! Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Danio rerio
xref: Reactome:REACT_99511 ! Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Taeniopygia guttata
xref: Reactome:REACT_99512 ! Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Rattus norvegicus
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004871
name: signal transducer activity
namespace: molecular_function
alt_id: GO:0005062
alt_id: GO:0009369
alt_id: GO:0009370
def: "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]
comment: Ligands do NOT have the molecular function 'signal transducer activity'.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW []
synonym: "quorum sensing response regulator activity" NARROW []
synonym: "quorum sensing signal generator activity" NARROW []
relationship: part_of GO:0007165 ! signal transduction
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "small-molecule carrier or transporter" RELATED []
xref: Reactome:REACT_6315 ! Virion-associated M2 protein mediated ion infusion, Homo sapiens
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0006810 ! transport

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0045308
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED []
synonym: "protein amino acid binding" EXACT []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein folding chaperone" NARROW [GOC:tb, GOC:mah, GOC:dph]
synonym: "protein tagging activity" RELATED []
xref: Reactome:REACT_100108 ! Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus
xref: Reactome:REACT_100287 ! Formation of the IGF:IGFBP-4 Complex, Canis familiaris
xref: Reactome:REACT_101129 ! Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus
xref: Reactome:REACT_102084 ! Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus
xref: Reactome:REACT_102457 ! An anchoring protein, SARA, recruits R-SMAD, Canis familiaris
xref: Reactome:REACT_103972 ! Type II receptor recruits type I receptor, Xenopus tropicalis
xref: Reactome:REACT_104488 ! Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus
xref: Reactome:REACT_104599 ! Type II receptor recruits type I receptor, Sus scrofa
xref: Reactome:REACT_105776 ! Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio
xref: Reactome:REACT_106189 ! Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus
xref: Reactome:REACT_107402 ! Formation of the IGF:IGFBP-4 Complex, Mus musculus
xref: Reactome:REACT_108283 ! Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis
xref: Reactome:REACT_108734 ! Exocyst complex formation, Rattus norvegicus
xref: Reactome:REACT_109392 ! Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus
xref: Reactome:REACT_110419 ! Type II receptor recruits type I receptor, Bos taurus
xref: Reactome:REACT_110570 ! Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa
xref: Reactome:REACT_15321 ! Formation of the IGF:IGFBP-1 Complex, Homo sapiens
xref: Reactome:REACT_15325 ! Formation of the IGF:IGFBP-4 Complex, Homo sapiens
xref: Reactome:REACT_15355 ! Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens
xref: Reactome:REACT_15394 ! Exocyst complex formation, Homo sapiens
xref: Reactome:REACT_15417 ! Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens
xref: Reactome:REACT_15419 ! Formation of the IGF:IGFBP-2 Complex, Homo sapiens
xref: Reactome:REACT_15506 ! Formation of the IGF:IGFBP-6 Complex, Homo sapiens
xref: Reactome:REACT_15520 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Homo sapiens
xref: Reactome:REACT_15541 ! Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens
xref: Reactome:REACT_20509 ! Exocytosis of Insulin, Mus musculus
xref: Reactome:REACT_20539 ! Traversal of the cortical actin network., Mus musculus
xref: Reactome:REACT_28794 ! Formation of the IGF:IGFBP-4 Complex, Sus scrofa
xref: Reactome:REACT_29512 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Caenorhabditis elegans
xref: Reactome:REACT_29669 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Danio rerio
xref: Reactome:REACT_29941 ! Formation of the IGF:IGFBP-4 Complex, Bos taurus
xref: Reactome:REACT_30571 ! Formation of the IGF:IGFBP-6 Complex, Danio rerio
xref: Reactome:REACT_30672 ! Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata
xref: Reactome:REACT_31305 ! Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata
xref: Reactome:REACT_31537 ! Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus
xref: Reactome:REACT_31641 ! Type II receptor recruits type I receptor, Danio rerio
xref: Reactome:REACT_31648 ! An anchoring protein, SARA, recruits R-SMAD, Mus musculus
xref: Reactome:REACT_32973 ! Formation of the IGF:IGFBP-1 Complex, Canis familiaris
xref: Reactome:REACT_33135 ! An anchoring protein, SARA, recruits R-SMAD, Rattus norvegicus
xref: Reactome:REACT_34719 ! Formation of the IGF:IGFBP-1 Complex, Danio rerio
xref: Reactome:REACT_6923 ! An anchoring protein, SARA, recruits R-SMAD, Homo sapiens
xref: Reactome:REACT_6945 ! Type II receptor recruits type I receptor, Homo sapiens
xref: Reactome:REACT_77120 ! Formation of the IGF:IGFBP-2 Complex, Bos taurus
xref: Reactome:REACT_77540 ! Exocyst complex formation, Canis familiaris
xref: Reactome:REACT_77845 ! Exocyst complex formation, Danio rerio
xref: Reactome:REACT_78036 ! Exocyst complex formation, Drosophila melanogaster
xref: Reactome:REACT_78044 ! Exocyst complex formation, Xenopus tropicalis
xref: Reactome:REACT_78382 ! Formation of the IGF:IGFBP-1 Complex, Mus musculus
xref: Reactome:REACT_78466 ! Formation of the IGF:IGFBP-6 Complex, Canis familiaris
xref: Reactome:REACT_79611 ! Exocyst complex formation, Bos taurus
xref: Reactome:REACT_79634 ! Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris
xref: Reactome:REACT_80470 ! Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus
xref: Reactome:REACT_80778 ! Type II receptor recruits type I receptor, Mus musculus
xref: Reactome:REACT_83147 ! Type II receptor recruits type I receptor, Rattus norvegicus
xref: Reactome:REACT_83165 ! Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa
xref: Reactome:REACT_83532 ! Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis
xref: Reactome:REACT_85250 ! Formation of the IGF:IGFBP-2 Complex, Canis familiaris
xref: Reactome:REACT_85814 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Dictyostelium discoideum
xref: Reactome:REACT_85858 ! Formation of the IGF:IGFBP-2 Complex, Gallus gallus
xref: Reactome:REACT_85962 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Taeniopygia guttata
xref: Reactome:REACT_85975 ! An anchoring protein, SARA, recruits R-SMAD, Danio rerio
xref: Reactome:REACT_86333 ! Exocyst complex formation, Taeniopygia guttata
xref: Reactome:REACT_86955 ! Exocyst complex formation, Mus musculus
xref: Reactome:REACT_87187 ! An anchoring protein, SARA, recruits R-SMAD, Xenopus tropicalis
xref: Reactome:REACT_87374 ! Formation of the IGF:IGFBP-6 Complex, Sus scrofa
xref: Reactome:REACT_88068 ! Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris
xref: Reactome:REACT_88138 ! Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio
xref: Reactome:REACT_88223 ! Formation of the IGF:IGFBP-1 Complex, Sus scrofa
xref: Reactome:REACT_89261 ! Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata
xref: Reactome:REACT_90027 ! Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus
xref: Reactome:REACT_90105 ! Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis
xref: Reactome:REACT_90666 ! An anchoring protein, SARA, recruits R-SMAD, Sus scrofa
xref: Reactome:REACT_91560 ! Type II receptor recruits type I receptor, Canis familiaris
xref: Reactome:REACT_92029 ! Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus
xref: Reactome:REACT_93175 ! Formation of the IGF:IGFBP-1 Complex, Gallus gallus
xref: Reactome:REACT_93596 ! Formation of the IGF:IGFBP-6 Complex, Bos taurus
xref: Reactome:REACT_93938 ! Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus
xref: Reactome:REACT_94337 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Mus musculus
xref: Reactome:REACT_94522 ! Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata
xref: Reactome:REACT_94808 ! Formation of the IGF:IGFBP-6 Complex, Mus musculus
xref: Reactome:REACT_95241 ! Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus
xref: Reactome:REACT_95561 ! Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis
xref: Reactome:REACT_95914 ! Translocation of Preproinsulin to Endoplasmic Reticulum, Drosophila melanogaster
xref: Reactome:REACT_96236 ! Formation of the IGF:IGFBP-2 Complex, Mus musculus
xref: Reactome:REACT_96264 ! Formation of the IGF:IGFBP-2 Complex, Danio rerio
xref: Reactome:REACT_98028 ! Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata
xref: Reactome:REACT_98807 ! An anchoring protein, SARA, recruits R-SMAD, Bos taurus
xref: Reactome:REACT_99562 ! Exocyst complex formation, Gallus gallus
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular component" EXACT []
synonym: "cellular component unknown" NARROW []
xref: NIF_Subcellular:sao1337158144
disjoint_from: GO:0003674 ! molecular_function

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cell_wall
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005624
name: membrane fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
relationship: part_of GO:0005634 ! nucleus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoplasm
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
relationship: part_of GO:0005739 ! mitochondrion
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
synonym: "peroxisome vesicle" BROAD []
xref: NIF_Subcellular:sao499555322
xref: Wikipedia:Peroxisome
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "ER" EXACT []
xref: NIF_Subcellular:sao1036339110
xref: Wikipedia:Endoplasmic_reticulum
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
synonym: "MTOC" EXACT []
synonym: "microtubule organising centre" EXACT []
xref: Wikipedia:Microtubule_organizing_center
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
alt_id: GO:0033279
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal RNA" RELATED []
synonym: "ribosomal subunit" RELATED [GOC:mah, GOC:vw]
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoskeleton
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:REACT_101193 ! Metabolism of carbohydrates, Sus scrofa
xref: Reactome:REACT_102834 ! Metabolism of carbohydrates, Mus musculus
xref: Reactome:REACT_103806 ! Metabolism of carbohydrates, Mycobacterium tuberculosis
xref: Reactome:REACT_104502 ! Metabolism of carbohydrates, Gallus gallus
xref: Reactome:REACT_105321 ! Metabolism of carbohydrates, Escherichia coli
xref: Reactome:REACT_106046 ! Metabolism of carbohydrates, Drosophila melanogaster
xref: Reactome:REACT_107409 ! Metabolism of carbohydrates, Caenorhabditis elegans
xref: Reactome:REACT_28218 ! Metabolism of carbohydrates, Xenopus tropicalis
xref: Reactome:REACT_32291 ! Metabolism of carbohydrates, Staphylococcus aureus N315
xref: Reactome:REACT_33141 ! Metabolism of carbohydrates, Taeniopygia guttata
xref: Reactome:REACT_33953 ! Metabolism of carbohydrates, Rattus norvegicus
xref: Reactome:REACT_34800 ! Metabolism of carbohydrates, Danio rerio
xref: Reactome:REACT_474 ! Metabolism of carbohydrates, Homo sapiens
xref: Reactome:REACT_77669 ! Metabolism of carbohydrates, Plasmodium falciparum
xref: Reactome:REACT_81945 ! Metabolism of carbohydrates, Schizosaccharomyces pombe
xref: Reactome:REACT_83038 ! Metabolism of carbohydrates, Arabidopsis thaliana
xref: Reactome:REACT_83329 ! Metabolism of carbohydrates, Saccharomyces cerevisiae
xref: Reactome:REACT_88330 ! Metabolism of carbohydrates, Bos taurus
xref: Reactome:REACT_88558 ! Metabolism of carbohydrates, Canis familiaris
xref: Reactome:REACT_96375 ! Metabolism of carbohydrates, Dictyostelium discoideum
xref: Reactome:REACT_98394 ! Metabolism of carbohydrates, Oryza sativa
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "DNA metabolism" EXACT []
synonym: "cellular DNA metabolism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein biosynthetic process" EXACT [GOC:curators]
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:REACT_100851 ! Translation, Saccharomyces cerevisiae
xref: Reactome:REACT_101045 ! Translation, Dictyostelium discoideum
xref: Reactome:REACT_101324 ! Translation, Canis familiaris
xref: Reactome:REACT_1014 ! Translation, Homo sapiens
xref: Reactome:REACT_103420 ! Translation, Plasmodium falciparum
xref: Reactome:REACT_105544 ! Translation, Arabidopsis thaliana
xref: Reactome:REACT_29980 ! Translation, Bos taurus
xref: Reactome:REACT_33559 ! Translation, Rattus norvegicus
xref: Reactome:REACT_77710 ! Translation, Drosophila melanogaster
xref: Reactome:REACT_79784 ! Translation, Danio rerio
xref: Reactome:REACT_81734 ! Translation, Schizosaccharomyces pombe
xref: Reactome:REACT_81833 ! Translation, Caenorhabditis elegans
xref: Reactome:REACT_82171 ! Translation, Xenopus tropicalis
xref: Reactome:REACT_83429 ! Translation, Taeniopygia guttata
xref: Reactome:REACT_83530 ! Translation, Gallus gallus
xref: Reactome:REACT_84182 ! Translation, Sus scrofa
xref: Reactome:REACT_86996 ! Translation, Oryza sativa
xref: Reactome:REACT_95535 ! Translation, Mus musculus
xref: Reactome:REACT_96394 ! Translation, Escherichia coli
xref: Wikipedia:Translation_(genetics)
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Reactome:REACT_100411 ! Chaperonin-mediated protein folding, Arabidopsis thaliana
xref: Reactome:REACT_104912 ! Chaperonin-mediated protein folding, Caenorhabditis elegans
xref: Reactome:REACT_105663 ! Chaperonin-mediated protein folding, Rattus norvegicus
xref: Reactome:REACT_106009 ! Chaperonin-mediated protein folding, Canis familiaris
xref: Reactome:REACT_106427 ! Chaperonin-mediated protein folding, Mus musculus
xref: Reactome:REACT_106894 ! Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris
xref: Reactome:REACT_106927 ! Chaperonin-mediated protein folding, Drosophila melanogaster
xref: Reactome:REACT_107029 ! Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster
xref: Reactome:REACT_108248 ! Chaperonin-mediated protein folding, Gallus gallus
xref: Reactome:REACT_109411 ! Formation of tubulin folding intermediates by CCT/TriC, Bos taurus
xref: Reactome:REACT_110417 ! Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus
xref: Reactome:REACT_16956 ! Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens
xref: Reactome:REACT_17001 ! Formation of tubulin folding intermediates by CCT/TriC, Mus musculus
xref: Reactome:REACT_17004 ! Chaperonin-mediated protein folding, Homo sapiens
xref: Reactome:REACT_17056 ! Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus
xref: Reactome:REACT_23878 ! N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens
xref: Reactome:REACT_30906 ! Chaperonin-mediated protein folding, Oryza sativa
xref: Reactome:REACT_32155 ! Chaperonin-mediated protein folding, Saccharomyces cerevisiae
xref: Reactome:REACT_32255 ! Chaperonin-mediated protein folding, Schizosaccharomyces pombe
xref: Reactome:REACT_33395 ! Formation of tubulin folding intermediates by CCT/TriC, Mus musculus
xref: Reactome:REACT_77627 ! Chaperonin-mediated protein folding, Plasmodium falciparum
xref: Reactome:REACT_77963 ! Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae
xref: Reactome:REACT_78530 ! Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus
xref: Reactome:REACT_81155 ! Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans
xref: Reactome:REACT_83906 ! Chaperonin-mediated protein folding, Dictyostelium discoideum
xref: Reactome:REACT_85492 ! Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa
xref: Reactome:REACT_85496 ! Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum
xref: Reactome:REACT_86318 ! Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana
xref: Reactome:REACT_91676 ! Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe
xref: Reactome:REACT_92785 ! Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum
xref: Reactome:REACT_92961 ! Chaperonin-mediated protein folding, Xenopus tropicalis
xref: Reactome:REACT_92981 ! Chaperonin-mediated protein folding, Taeniopygia guttata
xref: Reactome:REACT_94123 ! Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata
xref: Reactome:REACT_94443 ! Formation of tubulin folding intermediates by CCT/TriC, Danio rerio
xref: Reactome:REACT_94772 ! Chaperonin-mediated protein folding, Sus scrofa
xref: Reactome:REACT_96773 ! Chaperonin-mediated protein folding, Danio rerio
xref: Reactome:REACT_97016 ! Chaperonin-mediated protein folding, Bos taurus
xref: Reactome:REACT_97220 ! Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis
xref: Reactome:REACT_98132 ! Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa
xref: Wikipedia:Protein_folding
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006464
name: protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "process resulting in protein modification" RELATED []
synonym: "protein tagging activity" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "lipid metabolism" EXACT []
xref: Reactome:REACT_104930 ! Lipid digestion, mobilization, and transport, Drosophila melanogaster
xref: Reactome:REACT_107479 ! Lipid digestion, mobilization, and transport, Xenopus tropicalis
xref: Reactome:REACT_108775 ! Lipid digestion, mobilization, and transport, Canis familiaris
xref: Reactome:REACT_28745 ! Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae
xref: Reactome:REACT_31395 ! Lipid digestion, mobilization, and transport, Sus scrofa
xref: Reactome:REACT_32539 ! Lipid digestion, mobilization, and transport, Bos taurus
xref: Reactome:REACT_33836 ! Lipid digestion, mobilization, and transport, Rattus norvegicus
xref: Reactome:REACT_602 ! Lipid digestion, mobilization, and transport, Homo sapiens
xref: Reactome:REACT_77176 ! Lipid digestion, mobilization, and transport, Danio rerio
xref: Reactome:REACT_77191 ! Lipid digestion, mobilization, and transport, Arabidopsis thaliana
xref: Reactome:REACT_79244 ! Lipid digestion, mobilization, and transport, Plasmodium falciparum
xref: Reactome:REACT_81778 ! Lipid digestion, mobilization, and transport, Oryza sativa
xref: Reactome:REACT_82512 ! Lipid digestion, mobilization, and transport, Taeniopygia guttata
xref: Reactome:REACT_82723 ! Lipid digestion, mobilization, and transport, Escherichia coli
xref: Reactome:REACT_90757 ! Lipid digestion, mobilization, and transport, Mus musculus
xref: Reactome:REACT_94607 ! Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis
xref: Reactome:REACT_97906 ! Lipid digestion, mobilization, and transport, Gallus gallus
xref: Reactome:REACT_98052 ! Lipid digestion, mobilization, and transport, Caenorhabditis elegans
xref: Reactome:REACT_98129 ! Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe
xref: Reactome:REACT_99706 ! Lipid digestion, mobilization, and transport, Dictyostelium discoideum
xref: Wikipedia:Lipid_metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "vitamin metabolism" EXACT []
xref: Reactome:REACT_101808 ! Metabolism of vitamins and cofactors, Bos taurus
xref: Reactome:REACT_101968 ! Metabolism of vitamins and cofactors, Saccharomyces cerevisiae
xref: Reactome:REACT_103646 ! Metabolism of vitamins and cofactors, Staphylococcus aureus N315
xref: Reactome:REACT_105907 ! Metabolism of vitamins and cofactors, Danio rerio
xref: Reactome:REACT_106152 ! Metabolism of vitamins and cofactors, Xenopus tropicalis
xref: Reactome:REACT_108558 ! Metabolism of vitamins and cofactors, Rattus norvegicus
xref: Reactome:REACT_110948 ! Metabolism of vitamins and cofactors, Sus scrofa
xref: Reactome:REACT_11193 ! Metabolism of vitamins and cofactors, Homo sapiens
xref: Reactome:REACT_30091 ! Metabolism of vitamins and cofactors, Oryza sativa
xref: Reactome:REACT_33738 ! Metabolism of vitamins and cofactors, Mycobacterium tuberculosis
xref: Reactome:REACT_34161 ! Metabolism of vitamins and cofactors, Mus musculus
xref: Reactome:REACT_78899 ! Metabolism of vitamins and cofactors, Caenorhabditis elegans
xref: Reactome:REACT_81509 ! Metabolism of vitamins and cofactors, Gallus gallus
xref: Reactome:REACT_82129 ! Metabolism of vitamins and cofactors, Taeniopygia guttata
xref: Reactome:REACT_83508 ! Metabolism of vitamins and cofactors, Arabidopsis thaliana
xref: Reactome:REACT_87513 ! Metabolism of vitamins and cofactors, Schizosaccharomyces pombe
xref: Reactome:REACT_88850 ! Metabolism of vitamins and cofactors, Dictyostelium discoideum
xref: Reactome:REACT_96278 ! Metabolism of vitamins and cofactors, Plasmodium falciparum
xref: Reactome:REACT_96904 ! Metabolism of vitamins and cofactors, Drosophila melanogaster
xref: Reactome:REACT_97734 ! Metabolism of vitamins and cofactors, Escherichia coli
xref: Reactome:REACT_97893 ! Metabolism of vitamins and cofactors, Canis familiaris
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "auxiliary transport protein activity" RELATED [GOC:mah]
synonym: "small molecule transport" NARROW []
synonym: "solute:solute exchange" NARROW []
synonym: "transport accessory protein activity" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC.
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
subset: high_level_annotation_qc
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "organelle organisation" EXACT [GOC:curators]
synonym: "organelle organization and biogenesis" RELATED [GOC:mah, GOC:jl, GOC:dph]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT [GOC:curators]
synonym: "nuclear organization" EXACT [GOC:curators]
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007047
name: cellular cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation" EXACT [GOC:curators]
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007114
name: cell budding
namespace: biological_process
def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "budding" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007124
name: pseudohyphal growth
namespace: biological_process
def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell adhesion molecule activity" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
alt_id: GO:0023033
def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "signaling cascade" NARROW []
synonym: "signaling pathway" RELATED []
synonym: "signalling cascade" NARROW []
synonym: "signalling pathway" RELATED [GOC:mah]
xref: Reactome:REACT_100624 ! EGFR interacts with phospholipase C-gamma, Gallus gallus
xref: Reactome:REACT_102354 ! EGFR interacts with phospholipase C-gamma, Canis familiaris
xref: Reactome:REACT_12478 ! EGFR interacts with phospholipase C-gamma, Homo sapiens
xref: Reactome:REACT_31232 ! EGFR interacts with phospholipase C-gamma, Rattus norvegicus
xref: Reactome:REACT_78535 ! EGFR interacts with phospholipase C-gamma, Xenopus tropicalis
xref: Reactome:REACT_89740 ! EGFR interacts with phospholipase C-gamma, Taeniopygia guttata
xref: Reactome:REACT_93680 ! EGFR interacts with phospholipase C-gamma, Danio rerio
xref: Reactome:REACT_98872 ! EGFR interacts with phospholipase C-gamma, Mus musculus
xref: Wikipedia:Signal_transduction
relationship: regulates GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "biological process" EXACT []
synonym: "biological process unknown" NARROW []
synonym: "physiological process" EXACT []
xref: Wikipedia:Biological_process
disjoint_from: GO:0005575 ! cellular_component

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" EXACT []
xref: EC:3.4
xref: Reactome:REACT_106748 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus
xref: Reactome:REACT_110349 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus
xref: Reactome:REACT_13710 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens
xref: Reactome:REACT_19284 ! Proteolytic processing of Slit, Homo sapiens
xref: Reactome:REACT_93020 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus
xref: Reactome:REACT_99630 ! gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009405
name: pathogenesis
namespace: biological_process
def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself.
subset: goslim_candida
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
synonym: "virulence" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Biological_membrane
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0016023
name: cytoplasmic membrane-bounded vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoplasmic membrane bounded vesicle" EXACT []
synonym: "cytoplasmic membrane-enclosed vesicle" EXACT []
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0016044
name: cellular membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "membrane organisation" EXACT [GOC:curators]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:REACT_101524 ! Membrane Trafficking, Dictyostelium discoideum
xref: Reactome:REACT_103082 ! Membrane Trafficking, Schizosaccharomyces pombe
xref: Reactome:REACT_11123 ! Membrane Trafficking, Homo sapiens
xref: Reactome:REACT_29278 ! Membrane Trafficking, Sus scrofa
xref: Reactome:REACT_32337 ! Membrane Trafficking, Taeniopygia guttata
xref: Reactome:REACT_33741 ! Membrane Trafficking, Bos taurus
xref: Reactome:REACT_34084 ! Membrane Trafficking, Caenorhabditis elegans
xref: Reactome:REACT_78213 ! Membrane Trafficking, Plasmodium falciparum
xref: Reactome:REACT_78288 ! Membrane Trafficking, Xenopus tropicalis
xref: Reactome:REACT_83546 ! Membrane Trafficking, Oryza sativa
xref: Reactome:REACT_86557 ! Membrane Trafficking, Arabidopsis thaliana
xref: Reactome:REACT_87431 ! Membrane Trafficking, Drosophila melanogaster
xref: Reactome:REACT_88307 ! Membrane Trafficking, Mus musculus
xref: Reactome:REACT_91154 ! Membrane Trafficking, Saccharomyces cerevisiae
xref: Reactome:REACT_93714 ! Membrane Trafficking, Danio rerio
xref: Reactome:REACT_95586 ! Membrane Trafficking, Gallus gallus
xref: Reactome:REACT_96516 ! Membrane Trafficking, Canis familiaris
xref: Reactome:REACT_97881 ! Membrane Trafficking, Rattus norvegicus
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "RNA metabolism" EXACT []
xref: Reactome:REACT_107259 ! Metabolism of RNA, Sus scrofa
xref: Reactome:REACT_107652 ! Metabolism of RNA, Schizosaccharomyces pombe
xref: Reactome:REACT_110289 ! Metabolism of RNA, Danio rerio
xref: Reactome:REACT_21257 ! Metabolism of RNA, Homo sapiens
xref: Reactome:REACT_30579 ! Metabolism of RNA, Xenopus tropicalis
xref: Reactome:REACT_31367 ! Metabolism of RNA, Dictyostelium discoideum
xref: Reactome:REACT_33720 ! Metabolism of RNA, Plasmodium falciparum
xref: Reactome:REACT_80071 ! Metabolism of RNA, Caenorhabditis elegans
xref: Reactome:REACT_83630 ! Metabolism of RNA, Taeniopygia guttata
xref: Reactome:REACT_84169 ! Metabolism of RNA, Canis familiaris
xref: Reactome:REACT_85788 ! Metabolism of RNA, Oryza sativa
xref: Reactome:REACT_88316 ! Metabolism of RNA, Mus musculus
xref: Reactome:REACT_89992 ! Metabolism of RNA, Saccharomyces cerevisiae
xref: Reactome:REACT_91556 ! Metabolism of RNA, Bos taurus
xref: Reactome:REACT_92152 ! Metabolism of RNA, Drosophila melanogaster
xref: Reactome:REACT_94876 ! Metabolism of RNA, Arabidopsis thaliana
xref: Reactome:REACT_99403 ! Metabolism of RNA, Rattus norvegicus
xref: Reactome:REACT_99885 ! Metabolism of RNA, Gallus gallus
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1
xref: Reactome:REACT_102858 ! Diiodinated tyrosine can be deiodinated, Mus musculus
xref: Reactome:REACT_102973 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris
xref: Reactome:REACT_103874 ! Monoiodinated tyrosine can be deiodinated, Canis familiaris
xref: Reactome:REACT_104604 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio
xref: Reactome:REACT_105062 ! Monoiodinated tyrosine can be deiodinated, Danio rerio
xref: Reactome:REACT_105121 ! Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans
xref: Reactome:REACT_106088 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus
xref: Reactome:REACT_106276 ! Monoiodinated tyrosine can be deiodinated, Rattus norvegicus
xref: Reactome:REACT_107002 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa
xref: Reactome:REACT_107467 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus
xref: Reactome:REACT_108745 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata
xref: Reactome:REACT_109500 ! Monoiodinated tyrosine can be deiodinated, Bos taurus
xref: Reactome:REACT_110582 ! Diiodinated tyrosine can be deiodinated, Rattus norvegicus
xref: Reactome:REACT_15389 ! Monoiodinated tyrosine can be deiodinated, Homo sapiens
xref: Reactome:REACT_15410 ! Diiodinated tyrosine can be deiodinated, Homo sapiens
xref: Reactome:REACT_17006 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens
xref: Reactome:REACT_17042 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens
xref: Reactome:REACT_29212 ! Diiodinated tyrosine can be deiodinated, Canis familiaris
xref: Reactome:REACT_30160 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus
xref: Reactome:REACT_31762 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus
xref: Reactome:REACT_32960 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus
xref: Reactome:REACT_34705 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus
xref: Reactome:REACT_44470 ! Monoiodinated tyrosine can be deiodinated, Mus musculus
xref: Reactome:REACT_78923 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata
xref: Reactome:REACT_84842 ! Diiodinated tyrosine can be deiodinated, Gallus gallus
xref: Reactome:REACT_86178 ! Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis
xref: Reactome:REACT_88304 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus
xref: Reactome:REACT_89057 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus
xref: Reactome:REACT_90394 ! Diiodinated tyrosine can be deiodinated, Xenopus tropicalis
xref: Reactome:REACT_91638 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana
xref: Reactome:REACT_91952 ! Monoiodinated tyrosine can be deiodinated, Gallus gallus
xref: Reactome:REACT_92075 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis
xref: Reactome:REACT_92434 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris
xref: Reactome:REACT_93539 ! Diiodinated tyrosine can be deiodinated, Drosophila melanogaster
xref: Reactome:REACT_93974 ! Diiodinated tyrosine can be deiodinated, Taeniopygia guttata
xref: Reactome:REACT_95169 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio
xref: Reactome:REACT_95558 ! Monoiodinated tyrosine can be deiodinated, Sus scrofa
xref: Reactome:REACT_95573 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans
xref: Reactome:REACT_97234 ! Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans
xref: Reactome:REACT_97568 ! Diiodinated tyrosine can be deiodinated, Sus scrofa
xref: Reactome:REACT_97851 ! Diiodinated tyrosine can be deiodinated, Bos taurus
xref: Reactome:REACT_98022 ! Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster
xref: Reactome:REACT_99085 ! palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa
xref: Reactome:REACT_99794 ! Diiodinated tyrosine can be deiodinated, Danio rerio
xref: Reactome:REACT_99989 ! Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: EC:2
xref: Reactome:REACT_25050 ! Molybdenum ion transfer onto molybdopterin, Homo sapiens
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016779
name: nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2.7.7
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: EC:3
xref: Reactome:REACT_110436 ! Hydrolysis of phosphatidylcholine, Bos taurus
xref: Reactome:REACT_15331 ! Hydrolysis of phosphatidylcholine, Homo sapiens
xref: Reactome:REACT_83734 ! Hydrolysis of phosphatidylcholine, Danio rerio
xref: Reactome:REACT_84047 ! Hydrolysis of phosphatidylcholine, Xenopus tropicalis
xref: Reactome:REACT_87959 ! Hydrolysis of phosphatidylcholine, Gallus gallus
xref: Reactome:REACT_88159 ! Hydrolysis of phosphatidylcholine, Canis familiaris
xref: Reactome:REACT_90118 ! Hydrolysis of phosphatidylcholine, Mus musculus
xref: Reactome:REACT_91045 ! Hydrolysis of phosphatidylcholine, Taeniopygia guttata
xref: Reactome:REACT_98572 ! Hydrolysis of phosphatidylcholine, Rattus norvegicus
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other lyase activity" NARROW []
xref: EC:4
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]
comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other isomerase activity" NARROW []
xref: EC:5
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: EC:6
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children.
subset: goslim_candida
subset: goslim_pombe
subset: gosubset_prok
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function
relationship: regulates GO:0003674 ! molecular_function
relationship: regulates GO:0008150 ! biological_process

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_candida
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
subset: goslim_candida
subset: goslim_yeast
synonym: "tRNA" RELATED []
synonym: "transfer RNA" RELATED []
relationship: part_of GO:0006412 ! translation
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Transposon
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042221
name: response to chemical stimulus
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Annotations to this term will be removed during annotation QC.
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
subset: high_level_annotation_qc
synonym: "response to chemical substance" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "ribosomal chaperone activity" RELATED []
synonym: "ribosome biogenesis and assembly" EXACT []
xref: Wikipedia:Ribosome_biogenesis
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042493
name: response to drug
namespace: biological_process
alt_id: GO:0017035
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
subset: goslim_candida
subset: gosubset_prok
synonym: "drug resistance" RELATED []
synonym: "drug susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044419
name: interspecies interaction between organisms
namespace: biological_process
def: "Any process in which an organism has an effect on an organism of a different species." [GOC:cc]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "translation factor activity" EXACT []
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators]
subset: goslim_candida
subset: gosubset_prok
synonym: "terminal differentiation" RELATED [GOC:tb, GOC:dph]
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0070732
name: spindle envelope
namespace: cellular_component
def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
subset: goslim_candida
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component
created_by: midori
creation_date: 2009-06-18T12:00:59Z

[Term]
id: GO:0070783
name: growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth
created_by: midori
creation_date: 2009-07-07T02:21:14Z

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "cell wall organisation" EXACT [GOC:curators]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process
created_by: midori
creation_date: 2010-01-13T03:33:07Z

[Typedef]
id: has_part
name: has_part
namespace: gene_ontology
xref: OBO_REL:has_part
is_transitive: true
created_by: midori
creation_date: 2009-07-30T12:00:35Z

[Typedef]
id: negatively_regulates
name: negatively_regulates
namespace: gene_ontology

[Typedef]
id: occurs_in
name: occurs in
namespace: gene_ontology
xref: BFO:0000066

[Typedef]
id: part_of
name: part_of
namespace: gene_ontology
xref: OBO_REL:part_of
is_transitive: true

[Typedef]
id: positively_regulates
name: positively_regulates
namespace: gene_ontology

[Typedef]
id: regulates
name: regulates
namespace: gene_ontology