format-version: 1.2
date: 25:09:2009 11:40
auto-generated-by: OBO-Edit 2.1-beta1
saved-by: jane
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
remark: cvs version: $Revision: 1.7 $

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai]
subset: goslim_candida
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:449273 "Mitotic Telophase /Cytokinesis"
xref: Reactome:470393 "Mitotic Telophase /Cytokinesis"
xref: Reactome:488068 "Mitotic Telophase /Cytokinesis"
xref: Reactome:508035 "Mitotic Telophase /Cytokinesis"
xref: Reactome:517891 "Mitotic Telophase /Cytokinesis"
xref: Reactome:526715 "Mitotic Telophase /Cytokinesis"
xref: Reactome:531490 "Mitotic Telophase /Cytokinesis"
xref: Reactome:542630 "Mitotic Telophase /Cytokinesis"
xref: Reactome:547945 "Mitotic Telophase /Cytokinesis"
xref: Reactome:552520 "Mitotic Telophase /Cytokinesis"
xref: Reactome:558142 "Mitotic Telophase /Cytokinesis"
xref: Reactome:586024 "Mitotic Telophase /Cytokinesis"
xref: Reactome:592880 "Mitotic Telophase /Cytokinesis"
xref: Reactome:68884 "Mitotic Telophase /Cytokinesis"
xref: Wikipedia:Cytokinesis
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []
synonym: "molecular function unknown" NARROW []

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:1805 "RNA binding"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:7001 "helicase activity"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004672
name: protein kinase activity
namespace: molecular_function
alt_id: GO:0050222
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
comment: Note that triphosphate is used as a phosphate donor by at least one kinase.
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "protamine kinase activity" NARROW []
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:4030 "protein kinase activity"
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16]
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:1887 "phosphoprotein phosphatase activity"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0004871
name: signal transducer activity
namespace: molecular_function
def: "Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai, GOC:df]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "small-molecule carrier or transporter" RELATED []
xref: Reactome:1391 "transporter activity"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0045308
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED []
synonym: "protein amino acid binding" EXACT []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "protein tagging activity" RELATED []
xref: Reactome:6125 "protein binding"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular component" EXACT []
synonym: "cellular component unknown" NARROW []

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cell_wall
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005624
name: membrane fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
xref: Wikipedia:Cell_nucleus
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: Wikipedia:Nucleolus
relationship: part_of GO:0005634 ! nucleus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoplasm
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: Wikipedia:Mitochondrion
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
synonym: "peroxisome vesicle" BROAD []
xref: Wikipedia:Peroxisome
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "ER" EXACT []
xref: Wikipedia:Endoplasmic_reticulum
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: Wikipedia:Golgi_apparatus
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
synonym: "MTOC" EXACT []
synonym: "microtubule organising centre" EXACT []
xref: Wikipedia:Microtubule_organizing_center
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005856 ! cytoskeleton
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal RNA" RELATED []
xref: Wikipedia:Ribosome
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoskeleton
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: Wikipedia:Cell_membrane
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0016020 ! membrane

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
relationship: part_of GO:0005737 ! cytoplasm
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: gosubset_prok
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:448487 "Metabolism of carbohydrates"
xref: Reactome:469617 "Metabolism of carbohydrates"
xref: Reactome:487336 "Metabolism of carbohydrates"
xref: Reactome:507287 "Metabolism of carbohydrates"
xref: Reactome:517301 "Metabolism of carbohydrates"
xref: Reactome:526186 "Metabolism of carbohydrates"
xref: Reactome:531076 "Metabolism of carbohydrates"
xref: Reactome:536449 "Metabolism of carbohydrates"
xref: Reactome:542153 "Metabolism of carbohydrates"
xref: Reactome:547511 "Metabolism of carbohydrates"
xref: Reactome:552109 "Metabolism of carbohydrates"
xref: Reactome:557702 "Metabolism of carbohydrates"
xref: Reactome:568311 "Metabolism of carbohydrates"
xref: Reactome:581513 "Metabolism of carbohydrates"
xref: Reactome:585745 "Metabolism of carbohydrates"
xref: Reactome:592407 "Metabolism of carbohydrates"
xref: Reactome:595291 "Metabolism of carbohydrates"
xref: Reactome:597267 "Metabolism of carbohydrates"
xref: Reactome:598076 "Metabolism of carbohydrates"
xref: Reactome:599604 "Metabolism of carbohydrates"
xref: Reactome:600550 "Metabolism of carbohydrates"
xref: Reactome:602409 "Metabolism of carbohydrates"
xref: Reactome:71387 "Metabolism of carbohydrates"
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "DNA metabolism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006350
name: transcription
namespace: biological_process
def: "The synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:448636 "Transcription"
xref: Reactome:469764 "Transcription"
xref: Reactome:487521 "Transcription"
xref: Reactome:507482 "Transcription"
xref: Reactome:517466 "Transcription"
xref: Reactome:526339 "Transcription"
xref: Reactome:531172 "Transcription"
xref: Reactome:536547 "Transcription"
xref: Reactome:542268 "Transcription"
xref: Reactome:547614 "Transcription"
xref: Reactome:552218 "Transcription"
xref: Reactome:557808 "Transcription"
xref: Reactome:568425 "Transcription"
xref: Reactome:581627 "Transcription"
xref: Reactome:585958 "Transcription"
xref: Reactome:592524 "Transcription"
xref: Reactome:595359 "Transcription"
xref: Reactome:74159 "Transcription"
xref: Wikipedia:Transcription_(genetics)
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:448800 "Translation"
xref: Reactome:469916 "Translation"
xref: Reactome:487622 "Translation"
xref: Reactome:507577 "Translation"
xref: Reactome:517550 "Translation"
xref: Reactome:526417 "Translation"
xref: Reactome:531240 "Translation"
xref: Reactome:536611 "Translation"
xref: Reactome:542335 "Translation"
xref: Reactome:547676 "Translation"
xref: Reactome:552260 "Translation"
xref: Reactome:557879 "Translation"
xref: Reactome:568477 "Translation"
xref: Reactome:581688 "Translation"
xref: Reactome:585834 "Translation"
xref: Reactome:592595 "Translation"
xref: Reactome:595406 "Translation"
xref: Reactome:597395 "Translation"
xref: Reactome:598177 "Translation"
xref: Reactome:599776 "Translation"
xref: Reactome:72766 "Translation"
xref: Wikipedia:Translation_(genetics)
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Reactome:389960 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:389967 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:390466 "Chaperonin-mediated protein folding"
xref: Reactome:392033 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding"
xref: Reactome:448640 "Chaperonin-mediated protein folding"
xref: Reactome:448770 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:469768 "Chaperonin-mediated protein folding"
xref: Reactome:469885 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:487587 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:487589 "Chaperonin-mediated protein folding"
xref: Reactome:507422 "Chaperonin-mediated protein folding"
xref: Reactome:507545 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:517425 "Chaperonin-mediated protein folding"
xref: Reactome:517525 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:526299 "Chaperonin-mediated protein folding"
xref: Reactome:526394 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:531205 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:531207 "Chaperonin-mediated protein folding"
xref: Reactome:536535 "Chaperonin-mediated protein folding"
xref: Reactome:536580 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:542256 "Chaperonin-mediated protein folding"
xref: Reactome:542306 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:547600 "Chaperonin-mediated protein folding"
xref: Reactome:547647 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:552207 "Chaperonin-mediated protein folding"
xref: Reactome:552239 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:557798 "Chaperonin-mediated protein folding"
xref: Reactome:557852 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:568411 "Chaperonin-mediated protein folding"
xref: Reactome:568446 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:581613 "Chaperonin-mediated protein folding"
xref: Reactome:581659 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:585812 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:585814 "Chaperonin-mediated protein folding"
xref: Reactome:592510 "Chaperonin-mediated protein folding"
xref: Reactome:592570 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:595349 "Chaperonin-mediated protein folding"
xref: Reactome:595388 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Wikipedia:Protein_folding
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006464
name: protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "process resulting in protein modification" RELATED []
synonym: "protein tagging activity" RELATED []
xref: Reactome:163841 "Post-translational protein modification"
xref: Reactome:448468 "Post-translational protein modification"
xref: Reactome:469598 "Post-translational protein modification"
xref: Reactome:487317 "Post-translational protein modification"
xref: Reactome:507268 "Post-translational protein modification"
xref: Reactome:517285 "Post-translational protein modification"
xref: Reactome:526163 "Post-translational protein modification"
xref: Reactome:531060 "Post-translational protein modification"
xref: Reactome:536442 "Post-translational protein modification"
xref: Reactome:542137 "Post-translational protein modification"
xref: Reactome:547504 "Post-translational protein modification"
xref: Reactome:552404 "Post-translational protein modification"
xref: Reactome:557675 "Post-translational protein modification"
xref: Reactome:568295 "Post-translational protein modification"
xref: Reactome:581497 "Post-translational protein modification"
xref: Reactome:585741 "Post-translational protein modification"
xref: Reactome:592394 "Post-translational protein modification"
xref: Reactome:595284 "Post-translational protein modification"
xref: Reactome:597401 "Post-translational protein modification"
xref: Reactome:598181 "Post-translational protein modification"
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006519
name: cellular amino acid and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "amino acid and derivative metabolism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: gosubset_prok
synonym: "lipid metabolism" EXACT []
xref: Reactome:448458 "Metabolism of lipids and lipoproteins"
xref: Reactome:469588 "Metabolism of lipids and lipoproteins"
xref: Reactome:487307 "Metabolism of lipids and lipoproteins"
xref: Reactome:507258 "Metabolism of lipids and lipoproteins"
xref: Reactome:517280 "Metabolism of lipids and lipoproteins"
xref: Reactome:526158 "Metabolism of lipids and lipoproteins"
xref: Reactome:531055 "Metabolism of lipids and lipoproteins"
xref: Reactome:536437 "Metabolism of lipids and lipoproteins"
xref: Reactome:542134 "Metabolism of lipids and lipoproteins"
xref: Reactome:547525 "Metabolism of lipids and lipoproteins"
xref: Reactome:552094 "Metabolism of lipids and lipoproteins"
xref: Reactome:557672 "Metabolism of lipids and lipoproteins"
xref: Reactome:568290 "Metabolism of lipids and lipoproteins"
xref: Reactome:581492 "Metabolism of lipids and lipoproteins"
xref: Reactome:585774 "Metabolism of lipids and lipoproteins"
xref: Reactome:592389 "Metabolism of lipids and lipoproteins"
xref: Reactome:595297 "Metabolism of lipids and lipoproteins"
xref: Reactome:597258 "Metabolism of lipids and lipoproteins"
xref: Reactome:598099 "Metabolism of lipids and lipoproteins"
xref: Reactome:599584 "Metabolism of lipids and lipoproteins"
xref: Reactome:600579 "Metabolism of lipids and lipoproteins"
xref: Reactome:602390 "Metabolism of lipids and lipoproteins"
xref: Reactome:73923 "Metabolism of lipids and lipoproteins"
xref: Wikipedia:Lipid_metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "vitamin metabolism" EXACT []
xref: Reactome:196854 "Metabolism of vitamins and cofactors"
xref: Reactome:448501 "Metabolism of vitamins and cofactors"
xref: Reactome:469631 "Metabolism of vitamins and cofactors"
xref: Reactome:487350 "Metabolism of vitamins and cofactors"
xref: Reactome:507301 "Metabolism of vitamins and cofactors"
xref: Reactome:517315 "Metabolism of vitamins and cofactors"
xref: Reactome:526200 "Metabolism of vitamins and cofactors"
xref: Reactome:531086 "Metabolism of vitamins and cofactors"
xref: Reactome:536459 "Metabolism of vitamins and cofactors"
xref: Reactome:542163 "Metabolism of vitamins and cofactors"
xref: Reactome:547521 "Metabolism of vitamins and cofactors"
xref: Reactome:552114 "Metabolism of vitamins and cofactors"
xref: Reactome:557706 "Metabolism of vitamins and cofactors"
xref: Reactome:568321 "Metabolism of vitamins and cofactors"
xref: Reactome:581523 "Metabolism of vitamins and cofactors"
xref: Reactome:585808 "Metabolism of vitamins and cofactors"
xref: Reactome:592410 "Metabolism of vitamins and cofactors"
xref: Reactome:595340 "Metabolism of vitamins and cofactors"
xref: Reactome:597308 "Metabolism of vitamins and cofactors"
xref: Reactome:598109 "Metabolism of vitamins and cofactors"
xref: Reactome:599609 "Metabolism of vitamins and cofactors"
xref: Reactome:600553 "Metabolism of vitamins and cofactors"
xref: Reactome:602413 "Metabolism of vitamins and cofactors"
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "small molecule transport" NARROW []
synonym: "solute:solute exchange" NARROW []
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "organelle organisation" EXACT [GOC:curators]
synonym: "organelle organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT [GOC:curators]
synonym: "nuclear organization" EXACT [GOC:curators]
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007047
name: cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell wall organisation" EXACT [GOC:curators]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007114
name: cell budding
namespace: biological_process
def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "budding" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007124
name: pseudohyphal growth
namespace: biological_process
def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818]
subset: goslim_candida
subset: goslim_yeast
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell adhesion molecule activity" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "signaling" EXACT []
synonym: "signaling cascade" EXACT []
synonym: "signalling" EXACT []
synonym: "signalling cascade" EXACT []
xref: Reactome:212718 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:448734 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:469856 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:487553 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:507509 "EGFR interacts with phospholipase C-gamma"
xref: Wikipedia:Signal_transduction
is_a: GO:0008150 ! biological_process
relationship: regulates GO:0008150 ! biological_process

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "biological process" EXACT []
synonym: "biological process unknown" NARROW []
synonym: "physiological process" EXACT []
xref: Wikipedia:Biological_process

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" EXACT []
xref: EC:3.4
xref: Reactome:1687 "peptidase activity"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid." [GOC:ai]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009405
name: pathogenesis
namespace: biological_process
def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself.
subset: goslim_candida
subset: goslim_goa
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
synonym: "virulence" RELATED []
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Biological_membrane
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0016023
name: cytoplasmic membrane-bounded vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoplasmic membrane bounded vesicle" EXACT []
synonym: "cytoplasmic membrane-enclosed vesicle" EXACT []
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0016044
name: membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "membrane organisation" EXACT [GOC:curators]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:199991 "Membrane Trafficking"
xref: Reactome:448815 "Membrane Trafficking"
xref: Reactome:469931 "Membrane Trafficking"
xref: Reactome:487634 "Membrane Trafficking"
xref: Reactome:507593 "Membrane Trafficking"
xref: Reactome:517561 "Membrane Trafficking"
xref: Reactome:526427 "Membrane Trafficking"
xref: Reactome:531244 "Membrane Trafficking"
xref: Reactome:536615 "Membrane Trafficking"
xref: Reactome:542339 "Membrane Trafficking"
xref: Reactome:547680 "Membrane Trafficking"
xref: Reactome:552334 "Membrane Trafficking"
xref: Reactome:557889 "Membrane Trafficking"
xref: Reactome:568487 "Membrane Trafficking"
xref: Reactome:581698 "Membrane Trafficking"
xref: Reactome:585888 "Membrane Trafficking"
xref: Reactome:592605 "Membrane Trafficking"
xref: Reactome:595446 "Membrane Trafficking"
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA metabolism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
relationship: part_of GO:0008150 ! biological_process
is_a: GO:0006810 ! transport

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1
xref: Reactome:95 "oxidoreductase activity"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016779
name: nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2.7.7
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:3
xref: Reactome:450 "hydrolase activity"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other lyase activity" NARROW []
xref: EC:4
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other isomerase activity" NARROW []
xref: EC:5
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: EC:6
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
subset: goslim_candida
subset: goslim_pombe
subset: gosubset_prok
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005575 ! cellular_component

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process by which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_candida
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030528
name: transcription regulator activity
namespace: molecular_function
def: "Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "transcriptional regulator activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
synonym: "tRNA" RELATED []
synonym: "transfer RNA" RELATED []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Transposon
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042221
name: response to chemical stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to chemical substance" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:ma]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal chaperone activity" RELATED []
synonym: "ribosome biogenesis and assembly" EXACT []
xref: Wikipedia:Ribosome_biogenesis
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0042493
name: response to drug
namespace: biological_process
alt_id: GO:0017035
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
subset: goslim_candida
subset: gosubset_prok
synonym: "drug resistance" RELATED []
synonym: "drug susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044419
name: interspecies interaction between organisms
namespace: biological_process
def: "Any process by which an organism has an effect on an organism of a different species." [GOC:cc]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "translation factor activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators]
subset: goslim_candida
subset: gosubset_prok
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0008150 ! biological_process

[Term]
id: GO:0070732
name: spindle envelope
namespace: cellular_component
def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
subset: goslim_candida
subset: goslim_yeast
relationship: part_of GO:0005575 ! cellular_component
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0070783
name: growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth

[Typedef]
id: has_part
name: has_part
namespace: gene_ontology
is_transitive: true

[Typedef]
id: negatively_regulates
name: negatively_regulates
namespace: gene_ontology
is_a: regulates ! regulates

[Typedef]
id: part_of
name: part_of
namespace: gene_ontology
xref: OBO_REL:part_of
is_transitive: true

[Typedef]
id: positively_regulates
name: positively_regulates
namespace: gene_ontology
is_a: regulates ! regulates

[Typedef]
id: regulates
name: regulates
namespace: gene_ontology