format-version: 1.2
date: 21:05:2012 16:23
saved-by: tanyaberardini
auto-generated-by: OBO-Edit 2.1
subsetdef: goslim_aspergillus "Aspergillus GO slim"
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_metagenomics "Metagenomics GO slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
subsetdef: high_level_annotation_qc "High-level terms not to be used for direct annotation"
subsetdef: mf_needs_review "Catalytic activity terms in need of attention"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
remark: cvs version: $Revision: 1.3069 $
ontology: go

[Term]
id: GO:0000001
name: mitochondrion inheritance
namespace: biological_process
def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
synonym: "mitochondrial inheritance" EXACT []
is_a: GO:0048308 ! organelle inheritance
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0000002
name: mitochondrial genome maintenance
namespace: biological_process
def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0000003
name: reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "reproductive physiological process" EXACT []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000005
name: ribosomal chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913]
comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0042254
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0000006
name: high affinity zinc uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000007
name: low-affinity zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000008
name: thioredoxin
namespace: molecular_function
alt_id: GO:0000013
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd]
comment: This term was made obsolete because it represents gene products.
is_obsolete: true
consider: GO:0006467
consider: GO:0015036

[Term]
id: GO:0000009
name: alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248]
synonym: "1,6-alpha-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: Reactome:REACT_22295 "Addition of a third mannose to the N-glycan precursor by Alg2, Saccharomyces cerevisiae"
xref: Reactome:REACT_22383 "Addition of a third mannose to the N-glycan precursor by ALG2, Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000010
name: trans-hexaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [EC:2.5.1.30, RHEA:20839]
subset: gosubset_prok
synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30]
xref: EC:2.5.1.30
xref: KEGG:R05612
xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
xref: RHEA:20839
xref: RHEA:27797
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0000012
name: single strand break repair
namespace: biological_process
def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000014
name: single-stranded DNA specific endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah]
synonym: "ssDNA-specific endodeoxyribonuclease activity" EXACT [GOC:mah]
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0000015
name: phosphopyruvate hydratase complex
namespace: cellular_component
def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "enolase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000016
name: lactase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108]
synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108]
synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108]
xref: EC:3.2.1.108
xref: MetaCyc:LACTASE-RXN
xref: Reactome:REACT_100439 "lactose + H2O => D-glucose + D-galactose, Gallus gallus"
xref: Reactome:REACT_104113 "lactose + H2O => D-glucose + D-galactose, Rattus norvegicus"
xref: Reactome:REACT_105850 "lactose + H2O => D-glucose + D-galactose, Bos taurus"
xref: Reactome:REACT_109208 "lactose + H2O => D-glucose + D-galactose, Taeniopygia guttata"
xref: Reactome:REACT_109391 "lactose + H2O => D-glucose + D-galactose, Sus scrofa"
xref: Reactome:REACT_109447 "lactose + H2O => D-glucose + D-galactose, Danio rerio"
xref: Reactome:REACT_112431 "lactose + H2O => D-glucose + D-galactose, Caenorhabditis elegans"
xref: Reactome:REACT_114967 "lactose + H2O => D-glucose + D-galactose, Drosophila melanogaster"
xref: Reactome:REACT_30821 "lactose + H2O => D-glucose + D-galactose, Mus musculus"
xref: Reactome:REACT_78084 "lactose + H2O => D-glucose + D-galactose, Canis familiaris"
xref: Reactome:REACT_78754 "lactose + H2O => D-glucose + D-galactose, Xenopus tropicalis"
xref: Reactome:REACT_9455 "lactose + H2O => D-glucose + D-galactose, Homo sapiens"
xref: RHEA:10079
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0000017
name: alpha-glucoside transport
namespace: biological_process
def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732]
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0000018
name: regulation of DNA recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006310 ! DNA recombination
relationship: regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0000019
name: regulation of mitotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006312 ! mitotic recombination
relationship: regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0000020
name: negative regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732]
comment: This term was made obsolete because it describes a substrate-specific process.
is_obsolete: true
consider: GO:0045950

[Term]
id: GO:0000022
name: mitotic spindle elongation
namespace: biological_process
def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah]
synonym: "spindle elongation during mitosis" EXACT []
is_a: GO:0051231 ! spindle elongation
intersection_of: GO:0051231 ! spindle elongation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0000023
name: maltose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar metabolic process" EXACT []
synonym: "malt sugar metabolism" EXACT []
synonym: "maltose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0000024
name: maltose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar biosynthesis" EXACT []
synonym: "malt sugar biosynthetic process" EXACT []
synonym: "maltose anabolism" EXACT []
synonym: "maltose biosynthesis" EXACT []
synonym: "maltose formation" EXACT []
synonym: "maltose synthesis" EXACT []
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0000025
name: maltose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "malt sugar catabolic process" EXACT []
synonym: "malt sugar catabolism" EXACT []
synonym: "maltose breakdown" EXACT []
synonym: "maltose degradation" EXACT []
synonym: "maltose hydrolysis" NARROW []
xref: MetaCyc:MALTOSECAT-PWY
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0000026
name: alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
xref: Reactome:REACT_22123 "Addition of the seventh mannose to the N-glycan precursor by ALG9, inside the ER lumen, Homo sapiens"
xref: Reactome:REACT_22156 "Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11, Homo sapiens"
xref: Reactome:REACT_22220 "Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11, Saccharomyces cerevisiae"
xref: Reactome:REACT_22307 "Addition of the last mannose to the N-glycan precursor by ALG3, inside the ER lumen., Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000027
name: ribosomal large subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl]
subset: gosubset_prok
synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000028
name: ribosomal small subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl]
subset: gosubset_prok
synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah]
synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0042255 ! ribosome assembly
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0000030
name: mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
xref: EC:2.4.1.-
xref: Reactome:REACT_1018 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Homo sapiens"
xref: Reactome:REACT_105204 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Dictyostelium discoideum"
xref: Reactome:REACT_2179 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Homo sapiens"
xref: Reactome:REACT_22117 "Addition of the eighth mannose to the N-glycan precursor by ALG12, inside the ER lumen, Homo sapiens"
xref: Reactome:REACT_30252 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Rattus norvegicus"
xref: Reactome:REACT_34702 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Danio rerio"
xref: Reactome:REACT_63412 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Mus musculus"
xref: Reactome:REACT_87972 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Canis familiaris"
xref: Reactome:REACT_95740 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate, Gallus gallus"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0000031
name: mannosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0000032
name: cell wall mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall mannoprotein anabolism" EXACT []
synonym: "cell wall mannoprotein biosynthesis" EXACT []
synonym: "cell wall mannoprotein formation" EXACT []
synonym: "cell wall mannoprotein synthesis" EXACT []
is_a: GO:0006057 ! mannoprotein biosynthetic process
is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process

[Term]
id: GO:0000033
name: alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
xref: Reactome:REACT_22347 "Addition of a second mannose to the N-glycan precursor by ALG2, Homo sapiens"
xref: Reactome:REACT_22415 "Addition of the sixth mannose to the N-glycan precursor by ALG3., Homo sapiens"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000034
name: adenine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2]
subset: gosubset_prok
synonym: "ADase activity" EXACT [EC:3.5.4.2]
synonym: "adenase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2]
xref: EC:3.5.4.2
xref: MetaCyc:ADENINE-DEAMINASE-RXN
xref: RHEA:23691
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0000035
name: acyl binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0000036
name: acyl carrier activity
namespace: molecular_function
def: "Enables the directed movement of acyl groups into, out of, within or between cells." [CHEBI:22221, GOC:cb]
subset: gosubset_prok
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0000038
name: very long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any long-chain fatty acid which has a chain length greater than C18." [CHEBI:27283, GOC:hjd]
subset: gosubset_prok
synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf]
synonym: "very-long-chain fatty acid metabolic process" EXACT []
synonym: "very-long-chain fatty acid metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:0000039
name: plasma membrane long-chain fatty acid transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains component information.
is_obsolete: true
consider: GO:0005324
consider: GO:0005886

[Term]
id: GO:0000040
name: low-affinity iron ion transport
namespace: biological_process
def: "The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
synonym: "low affinity iron ion transport" EXACT []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0000041
name: transition metal ion transport
namespace: biological_process
def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732]
subset: gosubset_prok
synonym: "transition metal transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0000042
name: protein targeting to Golgi
namespace: biological_process
def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
synonym: "protein-Golgi targeting" EXACT []
is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi
is_a: GO:0006605 ! protein targeting
is_a: GO:0072600 ! establishment of protein localization in Golgi

[Term]
id: GO:0000044
name: ascorbate stabilization
namespace: biological_process
def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "vitamin C stabilization" EXACT []
is_obsolete: true

[Term]
id: GO:0000045
name: autophagic vacuole assembly
namespace: biological_process
def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464]
synonym: "autophagic vacuole formation" RELATED [GOC:mah]
synonym: "autophagosome biosynthesis" EXACT []
synonym: "autophagosome formation" EXACT []
synonym: "PAS formation" NARROW []
is_a: GO:0007033 ! vacuole organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0000046
name: autophagic vacuole fusion
namespace: biological_process
def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404]
synonym: "fusion of autophagosome with lysosome" NARROW []
is_a: GO:0048284 ! organelle fusion
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0000047
name: Rieske iron-sulfur protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rieske iron-sulphur protein" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0000048
name: peptidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921]
synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:REACT_102632 "Peptide transfer from P-site tRNA to the A-site tRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_104123 "Peptide transfer from P-site tRNA to the A-site tRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_112282 "Peptide transfer from P-site tRNA to the A-site tRNA, Gallus gallus"
xref: Reactome:REACT_115501 "Peptide transfer from P-site tRNA to the A-site tRNA, Rattus norvegicus"
xref: Reactome:REACT_1227 "Peptide transfer from P-site tRNA to the A-site tRNA, Homo sapiens"
xref: Reactome:REACT_28090 "Peptide transfer from P-site tRNA to the A-site tRNA, Arabidopsis thaliana"
xref: Reactome:REACT_31656 "Peptide transfer from P-site tRNA to the A-site tRNA, Taeniopygia guttata"
xref: Reactome:REACT_33679 "Peptide transfer from P-site tRNA to the A-site tRNA, Dictyostelium discoideum"
xref: Reactome:REACT_77497 "Peptide transfer from P-site tRNA to the A-site tRNA, Oryza sativa"
xref: Reactome:REACT_81539 "Peptide transfer from P-site tRNA to the A-site tRNA, Drosophila melanogaster"
xref: Reactome:REACT_87719 "Peptide transfer from P-site tRNA to the A-site tRNA, Mus musculus"
xref: Reactome:REACT_90185 "Peptide transfer from P-site tRNA to the A-site tRNA, Danio rerio"
xref: Reactome:REACT_90457 "Peptide transfer from P-site tRNA to the A-site tRNA, Canis familiaris"
xref: Reactome:REACT_91228 "Peptide transfer from P-site tRNA to the A-site tRNA, Caenorhabditis elegans"
xref: Reactome:REACT_95405 "Peptide transfer from P-site tRNA to the A-site tRNA, Plasmodium falciparum"
xref: Reactome:REACT_98179 "Peptide transfer from P-site tRNA to the A-site tRNA, Xenopus tropicalis"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0000049
name: tRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000050
name: urea cycle
namespace: biological_process
alt_id: GO:0006594
alt_id: GO:0006871
def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732]
synonym: "ornithine cycle" EXACT []
synonym: "urea biosynthesis" EXACT []
synonym: "urea biosynthetic process" EXACT []
xref: Reactome:REACT_100599 "Urea cycle, Oryza sativa"
xref: Reactome:REACT_107747 "Urea cycle, Mus musculus"
xref: Reactome:REACT_109525 "Urea cycle, Danio rerio"
xref: Reactome:REACT_31787 "Urea cycle, Taeniopygia guttata"
xref: Reactome:REACT_32463 "Urea cycle, Drosophila melanogaster"
xref: Reactome:REACT_32971 "Urea cycle, Caenorhabditis elegans"
xref: Reactome:REACT_33119 "Urea cycle, Bos taurus"
xref: Reactome:REACT_78616 "Urea cycle, Plasmodium falciparum"
xref: Reactome:REACT_80089 "Urea cycle, Canis familiaris"
xref: Reactome:REACT_81058 "Urea cycle, Dictyostelium discoideum"
xref: Reactome:REACT_82995 "Urea cycle, Mycobacterium tuberculosis"
xref: Reactome:REACT_83831 "Urea cycle, Rattus norvegicus"
xref: Reactome:REACT_84694 "Urea cycle, Saccharomyces cerevisiae"
xref: Reactome:REACT_847 "Urea cycle, Homo sapiens"
xref: Reactome:REACT_88394 "Urea cycle, Gallus gallus"
xref: Reactome:REACT_90218 "Urea cycle, Escherichia coli"
xref: Reactome:REACT_90565 "Urea cycle, Sus scrofa"
xref: Reactome:REACT_92378 "Urea cycle, Xenopus tropicalis"
xref: Reactome:REACT_95880 "Urea cycle, Staphylococcus aureus N315"
xref: Reactome:REACT_97366 "Urea cycle, Arabidopsis thaliana"
xref: Reactome:REACT_98985 "Urea cycle, Schizosaccharomyces pombe"
xref: Wikipedia:Urea_cycle
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043604 ! amide biosynthetic process
relationship: has_part GO:0004055 ! argininosuccinate synthase activity
relationship: has_part GO:0004056 ! argininosuccinate lyase activity
relationship: has_part GO:0004585 ! ornithine carbamoyltransferase activity

[Term]
id: GO:0000051
name: urea cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
subset: gosubset_prok
synonym: "urea cycle intermediate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0000052
name: citrulline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732]
subset: gosubset_prok
synonym: "citrulline metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process

[Term]
id: GO:0000053
name: argininosuccinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732]
synonym: "argininosuccinate metabolism" EXACT []
is_a: GO:0006575 ! cellular modified amino acid metabolic process

[Term]
id: GO:0000054
name: ribosomal subunit export from nucleus
namespace: biological_process
def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]
subset: goslim_yeast
synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah]
synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb]
is_a: GO:0033753 ! establishment of ribosome localization
is_a: GO:0051168 ! nuclear export
is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0000055
name: ribosomal large subunit export from nucleus
namespace: biological_process
alt_id: GO:0000057
def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal large subunit export from cell nucleus" EXACT []
synonym: "ribosomal large subunit export out of nucleus" EXACT []
synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal large subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000056
name: ribosomal small subunit export from nucleus
namespace: biological_process
alt_id: GO:0000058
def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah]
synonym: "ribosomal small subunit export from cell nucleus" EXACT []
synonym: "ribosomal small subunit export out of nucleus" EXACT []
synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal small subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000059
name: protein import into nucleus, docking
namespace: biological_process
def: "A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736]
synonym: "protein docking during protein import into nucleus" EXACT []
synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein docking during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, docking" EXACT []
synonym: "protein-nucleus import, docking" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000060
name: protein import into nucleus, translocation
namespace: biological_process
def: "A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736]
comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "protein import into cell nucleus, translocation" EXACT []
synonym: "protein translocation during protein import into nucleus" EXACT []
synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein translocation during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT []
synonym: "protein-nucleus import, translocation" EXACT []
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000061
name: protein import into nucleus, substrate release
namespace: biological_process
def: "A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515]
synonym: "protein import into cell nucleus, substrate release" EXACT []
synonym: "protein substrate release during protein import into nucleus" EXACT []
synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein substrate release during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT []
synonym: "protein-nucleus import, substrate release" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000062
name: fatty-acyl-CoA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0000064
name: L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "L-ornithine transporter activity" BROAD []
xref: Reactome:REACT_100602 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Mus musculus"
xref: Reactome:REACT_102399 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Xenopus tropicalis"
xref: Reactome:REACT_103552 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus"
xref: Reactome:REACT_103610 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Canis familiaris"
xref: Reactome:REACT_104169 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Sus scrofa"
xref: Reactome:REACT_109285 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Caenorhabditis elegans"
xref: Reactome:REACT_115531 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Gallus gallus"
xref: Reactome:REACT_151 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Homo sapiens"
xref: Reactome:REACT_28177 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Drosophila melanogaster"
xref: Reactome:REACT_30708 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Arabidopsis thaliana"
xref: Reactome:REACT_78308 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Dictyostelium discoideum"
xref: Reactome:REACT_84383 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Oryza sativa"
xref: Reactome:REACT_88886 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Danio rerio"
xref: Reactome:REACT_88959 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Rattus norvegicus"
xref: Reactome:REACT_90007 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic), Taeniopygia guttata"
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
relationship: part_of GO:0015822 ! ornithine transport

[Term]
id: GO:0000066
name: mitochondrial ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015822 ! ornithine transport

[Term]
id: GO:0000067
name: DNA replication and chromosome cycle
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
is_obsolete: true
consider: GO:0006260
consider: GO:0007059
consider: GO:0051276

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
alt_id: GO:0016359
def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai]
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
is_a: GO:0000819 ! sister chromatid segregation
intersection_of: GO:0007059 ! chromosome segregation
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000072
name: M phase specific microtubule process
namespace: biological_process
def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
synonym: "M-phase specific microtubule process" EXACT []
is_a: GO:0007017 ! microtubule-based process
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0000073
name: spindle pole body separation
namespace: biological_process
alt_id: GO:0030475
def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051300 ! spindle pole body organization

[Term]
id: GO:0000075
name: cell cycle checkpoint
namespace: biological_process
def: "A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect." [GOC:curators, ISBN:0815316194]
xref: Reactome:REACT_100401 "Cell Cycle Checkpoints, Gallus gallus"
xref: Reactome:REACT_102145 "Cell Cycle Checkpoints, Saccharomyces cerevisiae"
xref: Reactome:REACT_102175 "Cell Cycle Checkpoints, Canis familiaris"
xref: Reactome:REACT_106487 "Cell Cycle Checkpoints, Rattus norvegicus"
xref: Reactome:REACT_109101 "Cell Cycle Checkpoints, Drosophila melanogaster"
xref: Reactome:REACT_1538 "Cell Cycle Checkpoints, Homo sapiens"
xref: Reactome:REACT_29957 "Cell Cycle Checkpoints, Bos taurus"
xref: Reactome:REACT_31789 "Cell Cycle Checkpoints, Dictyostelium discoideum"
xref: Reactome:REACT_33305 "Cell Cycle Checkpoints, Oryza sativa"
xref: Reactome:REACT_79078 "Cell Cycle Checkpoints, Sus scrofa"
xref: Reactome:REACT_84460 "Cell Cycle Checkpoints, Arabidopsis thaliana"
xref: Reactome:REACT_89660 "Cell Cycle Checkpoints, Xenopus tropicalis"
xref: Reactome:REACT_90285 "Cell Cycle Checkpoints, Mus musculus"
xref: Reactome:REACT_90465 "Cell Cycle Checkpoints, Caenorhabditis elegans"
xref: Reactome:REACT_92239 "Cell Cycle Checkpoints, Danio rerio"
xref: Reactome:REACT_96499 "Cell Cycle Checkpoints, Taeniopygia guttata"
xref: Reactome:REACT_99737 "Cell Cycle Checkpoints, Schizosaccharomyces pombe"
xref: Wikipedia:Cell_cycle_checkpoint
is_a: GO:0071156 ! regulation of cell cycle arrest
relationship: regulates GO:0007050 ! cell cycle arrest

[Term]
id: GO:0000076
name: DNA replication checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518]
is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle
is_a: GO:0031570 ! DNA integrity checkpoint

[Term]
id: GO:0000077
name: DNA damage checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mah, PMID:11891124]
synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
xref: Wikipedia:DNA_damage_checkpoint
xref: Wikipedia:Postreplication_checkpoint
is_a: GO:0006974 ! response to DNA damage stimulus
is_a: GO:0031570 ! DNA integrity checkpoint

[Term]
id: GO:0000078
name: cell shape checkpoint
namespace: biological_process
def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular shaping and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188]
synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw]
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0000079
name: regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]
synonym: "regulation of CDK activity" EXACT []
is_a: GO:0051726 ! regulation of cell cycle
is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0004693 ! cyclin-dependent protein kinase activity
relationship: regulates GO:0004693 ! cyclin-dependent protein kinase activity

[Term]
id: GO:0000080
name: G1 phase of mitotic cell cycle
namespace: biological_process
def: "G1 phase occurring as part of the mitotic cell cycle. G1 phase is the interval between the completion of DNA segregation (mitosis in a mitotic cell cycle) and the beginning of DNA synthesis. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:REACT_101162 "G1 Phase, Bos taurus"
xref: Reactome:REACT_1590 "G1 Phase, Homo sapiens"
xref: Reactome:REACT_29795 "G1 Phase, Taeniopygia guttata"
xref: Reactome:REACT_34060 "G1 Phase, Canis familiaris"
xref: Reactome:REACT_78665 "G1 Phase, Gallus gallus"
xref: Reactome:REACT_78866 "G1 Phase, Sus scrofa"
xref: Reactome:REACT_83686 "G1 Phase, Danio rerio"
xref: Reactome:REACT_91654 "G1 Phase, Mus musculus"
xref: Reactome:REACT_93384 "G1 Phase, Rattus norvegicus"
xref: Reactome:REACT_93574 "G1 Phase, Xenopus tropicalis"
is_a: GO:0051318 ! G1 phase
intersection_of: GO:0051318 ! G1 phase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000082
name: G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:REACT_101799 "G1/S Transition, Taeniopygia guttata"
xref: Reactome:REACT_102687 "G1/S Transition, Arabidopsis thaliana"
xref: Reactome:REACT_104020 "G1/S Transition, Canis familiaris"
xref: Reactome:REACT_104529 "G1/S Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_104577 "G1/S Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_106054 "G1/S Transition, Mus musculus"
xref: Reactome:REACT_107492 "G1/S Transition, Dictyostelium discoideum"
xref: Reactome:REACT_109784 "G1/S Transition, Oryza sativa"
xref: Reactome:REACT_109821 "G1/S Transition, Danio rerio"
xref: Reactome:REACT_110917 "G1/S Transition, Plasmodium falciparum"
xref: Reactome:REACT_1783 "G1/S Transition, Homo sapiens"
xref: Reactome:REACT_28713 "G1/S Transition, Xenopus tropicalis"
xref: Reactome:REACT_45711 "G1/S Transition, Caenorhabditis elegans"
xref: Reactome:REACT_84226 "G1/S Transition, Gallus gallus"
xref: Reactome:REACT_85355 "G1/S Transition, Sus scrofa"
xref: Reactome:REACT_87037 "G1/S Transition, Drosophila melanogaster"
xref: Reactome:REACT_88046 "G1/S Transition, Bos taurus"
xref: Reactome:REACT_95294 "G1/S Transition, Rattus norvegicus"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000083
name: regulation of transcription involved in G1/S phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in G1/S-phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_683 "G1/S-Specific Transcription, Homo sapiens"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0000084
name: S phase of mitotic cell cycle
namespace: biological_process
def: "S phase occurring as part of the mitotic cell cycle. S phase is the part of the cell cycle during which DNA synthesis takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194]
synonym: "S-phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_105829 "S Phase, Caenorhabditis elegans"
xref: Reactome:REACT_108550 "S Phase, Rattus norvegicus"
xref: Reactome:REACT_110039 "S Phase, Schizosaccharomyces pombe"
xref: Reactome:REACT_28988 "S Phase, Taeniopygia guttata"
xref: Reactome:REACT_32013 "S Phase, Mycobacterium tuberculosis"
xref: Reactome:REACT_34043 "S Phase, Oryza sativa"
xref: Reactome:REACT_78838 "S Phase, Plasmodium falciparum"
xref: Reactome:REACT_78845 "S Phase, Xenopus tropicalis"
xref: Reactome:REACT_81914 "S Phase, Saccharomyces cerevisiae"
xref: Reactome:REACT_82813 "S Phase, Arabidopsis thaliana"
xref: Reactome:REACT_85811 "S Phase, Sus scrofa"
xref: Reactome:REACT_89318 "S Phase, Drosophila melanogaster"
xref: Reactome:REACT_899 "S Phase, Homo sapiens"
xref: Reactome:REACT_92500 "S Phase, Mus musculus"
xref: Reactome:REACT_92759 "S Phase, Canis familiaris"
xref: Reactome:REACT_95174 "S Phase, Gallus gallus"
xref: Reactome:REACT_96081 "S Phase, Dictyostelium discoideum"
xref: Reactome:REACT_97603 "S Phase, Danio rerio"
xref: Reactome:REACT_99645 "S Phase, Bos taurus"
is_a: GO:0051320 ! S phase
intersection_of: GO:0051320 ! S phase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000085
name: G2 phase of mitotic cell cycle
namespace: biological_process
def: "G2 phase occurring as part of the mitotic cell cycle. G2 phase is the interval between the completion of DNA synthesis and the beginning of DNA segregation (mitosis in a mitotic cell cycle). A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:REACT_105223 "G2 Phase, Mus musculus"
xref: Reactome:REACT_105307 "G2 Phase, Canis familiaris"
xref: Reactome:REACT_106415 "G2 Phase, Xenopus tropicalis"
xref: Reactome:REACT_106836 "G2 Phase, Bos taurus"
xref: Reactome:REACT_1915 "G2 Phase, Homo sapiens"
xref: Reactome:REACT_28975 "G2 Phase, Rattus norvegicus"
xref: Reactome:REACT_85928 "G2 Phase, Sus scrofa"
xref: Reactome:REACT_96332 "G2 Phase, Danio rerio"
is_a: GO:0051319 ! G2 phase
intersection_of: GO:0051319 ! G2 phase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000086
name: G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:REACT_100942 "G2/M Transition, Danio rerio"
xref: Reactome:REACT_103766 "G2/M Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_107882 "G2/M Transition, Sus scrofa"
xref: Reactome:REACT_114616 "G2/M Transition, Arabidopsis thaliana"
xref: Reactome:REACT_2203 "G2/M Transition, Homo sapiens"
xref: Reactome:REACT_28929 "G2/M Transition, Xenopus tropicalis"
xref: Reactome:REACT_30388 "G2/M Transition, Gallus gallus"
xref: Reactome:REACT_34062 "G2/M Transition, Mus musculus"
xref: Reactome:REACT_77778 "G2/M Transition, Taeniopygia guttata"
xref: Reactome:REACT_83880 "G2/M Transition, Drosophila melanogaster"
xref: Reactome:REACT_87036 "G2/M Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_87230 "G2/M Transition, Canis familiaris"
xref: Reactome:REACT_87807 "G2/M Transition, Dictyostelium discoideum"
xref: Reactome:REACT_88018 "G2/M Transition, Caenorhabditis elegans"
xref: Reactome:REACT_88369 "G2/M Transition, Rattus norvegicus"
xref: Reactome:REACT_92702 "G2/M Transition, Bos taurus"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000087
name: M phase of mitotic cell cycle
namespace: biological_process
def: "M phase occurring as part of the mitotic cell cycle. M phase is the part of the cell cycle during which nuclear division takes place. A mitotic cell cycle is one which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells." [GOC:dph, GOC:mah, ISBN:0815316194]
synonym: "M-phase of mitotic cell cycle" EXACT []
xref: Reactome:REACT_105412 "M Phase, Mus musculus"
xref: Reactome:REACT_107095 "M Phase, Dictyostelium discoideum"
xref: Reactome:REACT_109059 "M Phase, Saccharomyces cerevisiae"
xref: Reactome:REACT_29488 "M Phase, Canis familiaris"
xref: Reactome:REACT_33490 "M Phase, Caenorhabditis elegans"
xref: Reactome:REACT_82055 "M Phase, Rattus norvegicus"
xref: Reactome:REACT_87132 "M Phase, Bos taurus"
xref: Reactome:REACT_88263 "M Phase, Xenopus tropicalis"
xref: Reactome:REACT_910 "M Phase, Homo sapiens"
xref: Reactome:REACT_92998 "M Phase, Danio rerio"
xref: Reactome:REACT_93131 "M Phase, Schizosaccharomyces pombe"
xref: Reactome:REACT_93566 "M Phase, Gallus gallus"
xref: Reactome:REACT_93720 "M Phase, Drosophila melanogaster"
xref: Reactome:REACT_94536 "M Phase, Taeniopygia guttata"
is_a: GO:0000279 ! M phase
intersection_of: GO:0000279 ! M phase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000088
name: mitotic prophase
namespace: biological_process
def: "Prophase occurring as part of mitosis. Prophase is the part of nuclear division in which, canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:REACT_100605 "Mitotic Prophase, Saccharomyces cerevisiae"
xref: Reactome:REACT_102122 "Mitotic Prophase, Mus musculus"
xref: Reactome:REACT_105127 "Mitotic Prophase, Danio rerio"
xref: Reactome:REACT_106058 "Mitotic Prophase, Drosophila melanogaster"
xref: Reactome:REACT_28443 "Mitotic Prophase, Taeniopygia guttata"
xref: Reactome:REACT_28607 "Mitotic Prophase, Rattus norvegicus"
xref: Reactome:REACT_32677 "Mitotic Prophase, Xenopus tropicalis"
xref: Reactome:REACT_765 "Mitotic Prophase, Homo sapiens"
xref: Reactome:REACT_79474 "Mitotic Prophase, Caenorhabditis elegans"
xref: Reactome:REACT_80300 "Mitotic Prophase, Gallus gallus"
xref: Reactome:REACT_83888 "Mitotic Prophase, Dictyostelium discoideum"
xref: Reactome:REACT_90347 "Mitotic Prophase, Canis familiaris"
xref: Reactome:REACT_90481 "Mitotic Prophase, Schizosaccharomyces pombe"
is_a: GO:0051324 ! prophase
intersection_of: GO:0051324 ! prophase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000089
name: mitotic metaphase
namespace: biological_process
def: "Metaphase occurring as part of mitosis. Metaphase is the part of nuclear division in which, canonically, chromosomes become aligned on the equatorial plate of the cell. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0815316194]
xref: Reactome:REACT_434 "Mitotic Metaphase, Homo sapiens"
is_a: GO:0051323 ! metaphase
intersection_of: GO:0051323 ! metaphase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000090
name: mitotic anaphase
namespace: biological_process
def: "Anaphase occurring as part of mitosis. Anaphase is the part of nuclear division in which sister chromatids (or chromosomes) separate and migrate towards the poles of the spindle. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, ISBN:0815316194]
xref: Reactome:REACT_1275 "Mitotic Anaphase, Homo sapiens"
is_a: GO:0051322 ! anaphase
intersection_of: GO:0051322 ! anaphase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000091
name: mitotic anaphase A
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GOC:dph, GOC:mah, ISBN:0815316194]
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000092
name: mitotic anaphase B
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GOC:dph, GOC:mah, ISBN:0815316194]
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000093
name: mitotic telophase
namespace: biological_process
def: "Telophase occurring as part of mitosis. Telophase is the part of nuclear division that, canonically, begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. Mitosis is the cell cycle process in which, canonically, the nucleus of a eukaryotic cell divides to produce two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:mah, ISBN:0721662544]
is_a: GO:0051326 ! telophase
intersection_of: GO:0051326 ! telophase
intersection_of: part_of GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000094
name: septin assembly and septum formation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined and the string name implied two separate processes.
is_obsolete: true
consider: GO:0000917
consider: GO:0000918
consider: GO:0000921

[Term]
id: GO:0000095
name: S-adenosylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015177
def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
synonym: "S-adenosyl methionine permease activity" EXACT []
synonym: "S-adenosyl methionine transporter activity" EXACT []
synonym: "S-adenosylmethionine permease activity" EXACT []
synonym: "S-adenosylmethionine transporter activity" BROAD []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0051185 ! coenzyme transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015805 ! S-adenosylmethionine transport

[Term]
id: GO:0000096
name: sulfur amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid metabolism" EXACT []
synonym: "sulphur amino acid metabolic process" EXACT []
synonym: "sulphur amino acid metabolism" EXACT []
xref: Reactome:REACT_115639 "Sulfur amino acid metabolism, Homo sapiens"
xref: Reactome:REACT_118084 "Sulfur amino acid metabolism, Rattus norvegicus"
xref: Reactome:REACT_118094 "Sulfur amino acid metabolism, Bos taurus"
xref: Reactome:REACT_118099 "Sulfur amino acid metabolism, Escherichia coli"
xref: Reactome:REACT_118166 "Sulfur amino acid metabolism, Taeniopygia guttata"
xref: Reactome:REACT_118184 "Sulfur amino acid metabolism, Canis familiaris"
xref: Reactome:REACT_118203 "Sulfur amino acid metabolism, Sus scrofa"
xref: Reactome:REACT_118227 "Sulfur amino acid metabolism, Mycobacterium tuberculosis"
xref: Reactome:REACT_118256 "Sulfur amino acid metabolism, Staphylococcus aureus N315"
xref: Reactome:REACT_118291 "Sulfur amino acid metabolism, Caenorhabditis elegans"
xref: Reactome:REACT_118309 "Sulfur amino acid metabolism, Gallus gallus"
xref: Reactome:REACT_118314 "Sulfur amino acid metabolism, Arabidopsis thaliana"
xref: Reactome:REACT_118323 "Sulfur amino acid metabolism, Xenopus tropicalis"
xref: Reactome:REACT_118328 "Sulfur amino acid metabolism, Drosophila melanogaster"
xref: Reactome:REACT_118349 "Sulfur amino acid metabolism, Oryza sativa"
xref: Reactome:REACT_118370 "Sulfur amino acid metabolism, Mus musculus"
xref: Reactome:REACT_118388 "Sulfur amino acid metabolism, Saccharomyces cerevisiae"
xref: Reactome:REACT_118463 "Sulfur amino acid metabolism, Schizosaccharomyces pombe"
xref: Reactome:REACT_118518 "Sulfur amino acid metabolism, Dictyostelium discoideum"
xref: Reactome:REACT_118541 "Sulfur amino acid metabolism, Danio rerio"
xref: Reactome:REACT_27187 "Sulfur amino acid metabolism, Mycobacterium tuberculosis"
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0000097
name: sulfur amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid anabolism" EXACT []
synonym: "sulfur amino acid biosynthesis" EXACT []
synonym: "sulfur amino acid formation" EXACT []
synonym: "sulfur amino acid synthesis" EXACT []
synonym: "sulphur amino acid biosynthesis" EXACT []
synonym: "sulphur amino acid biosynthetic process" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000098
name: sulfur amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid breakdown" EXACT []
synonym: "sulfur amino acid catabolism" EXACT []
synonym: "sulfur amino acid degradation" EXACT []
synonym: "sulphur amino acid catabolic process" EXACT []
synonym: "sulphur amino acid catabolism" EXACT []
xref: Reactome:REACT_115654 "Degradation of cysteine and homocysteine, Homo sapiens"
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0000099
name: sulfur amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sulfur amino acid transporter activity" BROAD []
synonym: "sulphur amino acid transmembrane transporter activity" EXACT []
synonym: "sulphur amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
relationship: part_of GO:0000101 ! sulfur amino acid transport

[Term]
id: GO:0000100
name: S-methylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015178
def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "S-methylmethionine permease activity" EXACT []
synonym: "S-methylmethionine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0072349 ! modified amino acid transmembrane transporter activity
relationship: part_of GO:0015806 ! S-methylmethionine transport

[Term]
id: GO:0000101
name: sulfur amino acid transport
namespace: biological_process
def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "sulphur amino acid transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0072348 ! sulfur compound transport

[Term]
id: GO:0000102
name: L-methionine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "L-methionine porter activity" RELATED []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015191 ! L-methionine transmembrane transporter activity

[Term]
id: GO:0000103
name: sulfate assimilation
namespace: biological_process
alt_id: GO:0019378
def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
subset: gosubset_prok
synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW []
synonym: "sulphate assimilation" EXACT []
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW []
xref: Reactome:REACT_27155 "Sulfate assimilation, Mycobacterium tuberculosis"
is_a: GO:0006790 ! sulfur compound metabolic process

[Term]
id: GO:0000104
name: succinate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019739
def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd]
subset: gosubset_prok
synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1]
synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1]
synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1]
xref: EC:1.3.99.1
xref: MetaCyc:SUCC-FUM-OXRED-RXN
xref: RHEA:16360
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0000105
name: histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine anabolism" EXACT []
synonym: "histidine biosynthesis" EXACT []
synonym: "histidine formation" EXACT []
synonym: "histidine synthesis" EXACT []
xref: MetaCyc:HISTSYN-PWY
is_a: GO:0006547 ! histidine metabolic process
is_a: GO:0009076 ! histidine family amino acid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process

[Term]
id: GO:0000107
name: imidazoleglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN]
subset: gosubset_prok
synonym: "glutamine amidotransferase:cyclase activity" BROAD []
synonym: "imidazole glycerol phosphate synthase activity" EXACT []
synonym: "imidazole-glycerol-phosphate synthase activity" RELATED []
synonym: "imidazoleglycerol phosphate synthase activity" EXACT []
xref: EC:2.4.2.-
xref: MetaCyc:GLUTAMIDOTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000108
name: repairosome
namespace: cellular_component
def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079]
comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators.
is_obsolete: true
replaced_by: GO:0000109

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000110
name: nucleotide-excision repair factor 1 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF1 complex" EXACT []
synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000111
name: nucleotide-excision repair factor 2 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF2 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000112
name: nucleotide-excision repair factor 3 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF3 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000113
name: nucleotide-excision repair factor 4 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF4 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000114
name: regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-dependent
intersection_of: part_of GO:0000080 ! G1 phase of mitotic cell cycle
relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle

[Term]
id: GO:0000115
name: regulation of transcription involved in S phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED []
synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT []
synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED []
synonym: "S-specific transcription in mitotic cell cycle" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-dependent
intersection_of: part_of GO:0000084 ! S phase of mitotic cell cycle
relationship: part_of GO:0000084 ! S phase of mitotic cell cycle

[Term]
id: GO:0000116
name: regulation of transcription involved in G2-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-dependent
intersection_of: part_of GO:0000085 ! G2 phase of mitotic cell cycle
relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle

[Term]
id: GO:0000117
name: regulation of transcription involved in G2/M-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006355 ! regulation of transcription, DNA-dependent
intersection_of: part_of GO:0000086 ! G2/M transition of mitotic cell cycle
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0000118
name: histone deacetylase complex
namespace: cellular_component
def: "A protein complex that possesses histone deacetylase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
synonym: "HDAC complex" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000120
name: RNA polymerase I transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0000121
name: glycerol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21]
synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21]
xref: EC:3.1.3.21
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
xref: RHEA:11479
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0000122
name: negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
alt_id: GO:0010553
alt_id: GO:0045816
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH]
synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED []
synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED []
synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT []
synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED []
synonym: "negative regulation of global transcription from Pol II promoter" RELATED []
synonym: "negative regulation of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0000123
name: histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000124
name: SAGA complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0070461 ! SAGA-type complex
relationship: has_part GO:0071819 ! DUBm complex

[Term]
id: GO:0000125
name: PCAF complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "PCAF histone acetylase-associated complex" EXACT []
synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386]
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0000126
name: transcription factor TFIIIB complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000127
name: transcription factor TFIIIC complex
namespace: cellular_component
def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000128
name: flocculation
namespace: biological_process
def: "The non-sexual aggregation of single-celled organisms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flocculation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000131
name: incipient cellular bud site
namespace: cellular_component
def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000132
name: establishment of mitotic spindle orientation
namespace: biological_process
alt_id: GO:0030607
alt_id: GO:0030609
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "mitotic spindle orientation" EXACT []
synonym: "orienting of mitotic spindle" EXACT []
is_a: GO:0040001 ! establishment of mitotic spindle localization
is_a: GO:0051294 ! establishment of spindle orientation
intersection_of: GO:0051294 ! establishment of spindle orientation
intersection_of: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030427 ! site of polarized growth

[Term]
id: GO:0000135
name: septin checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642]
is_a: GO:0031565 ! cytokinesis checkpoint

[Term]
id: GO:0000136
name: alpha-1,6-mannosyltransferase complex
namespace: cellular_component
def: "A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825]
is_a: GO:0030173 ! integral to Golgi membrane
is_a: GO:0031501 ! mannosyltransferase complex
relationship: part_of GO:0000137 ! Golgi cis cisterna

[Term]
id: GO:0000137
name: Golgi cis cisterna
namespace: cellular_component
def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000138
name: Golgi trans cisterna
namespace: cellular_component
def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
synonym: "late Golgi" RELATED [GOC:mah]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0000140
name: acylglycerone-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101]
synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT []
synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101]
synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
xref: EC:1.1.1.101
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
xref: Reactome:REACT_759 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+, Homo sapiens"
xref: RHEA:17344
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000142
name: cellular bud neck contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555]
synonym: "neck ring" EXACT []
is_a: GO:0005826 ! actomyosin contractile ring
intersection_of: GO:0005826 ! actomyosin contractile ring
intersection_of: part_of GO:0005935 ! cellular bud neck
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000144
name: cellular bud neck septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
intersection_of: GO:0005940 ! septin ring
intersection_of: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000145
name: exocyst
namespace: cellular_component
def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
synonym: "Sec6/8 complex" EXACT []
xref: Wikipedia:Exocyst
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0000146
name: microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
synonym: "actin filament motor activity" EXACT [GOC:dph]
synonym: "actin-filament motor activity" EXACT []
synonym: "muscle motor activity" NARROW []
synonym: "myosin ATPase activity" RELATED []
xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens"
xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0000147
name: actin cortical patch assembly
namespace: biological_process
def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah]
is_a: GO:0030866 ! cortical actin cytoskeleton organization
is_a: GO:0071844 ! cellular component assembly at cellular level

[Term]
id: GO:0000148
name: 1,3-beta-D-glucan synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34]
synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb]
synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0000149
name: SNARE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
synonym: "SNAP receptor binding" EXACT []
xref: Reactome:REACT_100180 "Acetylcholine synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_101078 "Noradrenalin synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_103740 "Acetylcholine synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_105540 "Vamp7 associated Lysosome to Plasma membrane transport, Mus musculus"
xref: Reactome:REACT_106347 "release of L-Glutamate at the synapse, Canis familiaris"
xref: Reactome:REACT_107235 "Vamp2 associated secretory vesicle to plasma membrane transport, Dictyostelium discoideum"
xref: Reactome:REACT_107965 "Noradrenalin synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_109894 "Vamp7 associated Lysosome to Plasma membrane transport, Dictyostelium discoideum"
xref: Reactome:REACT_110250 "Vamp2 associated secretory vesicle to plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_110371 "Release of noradrenaline at the synapse, Rattus norvegicus"
xref: Reactome:REACT_110396 "Vamp7 associated Lysosome to Plasma membrane transport, Xenopus tropicalis"
xref: Reactome:REACT_112169 "Acetylcholine synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_112728 "Release of noradrenaline at the synapse, Caenorhabditis elegans"
xref: Reactome:REACT_113606 "Glutamate synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_113753 "Exocytosis of Insulin, Danio rerio"
xref: Reactome:REACT_114225 "Noradrenalin synaptic vesicle docking and priming, Gallus gallus"
xref: Reactome:REACT_114547 "Noradrenalin synaptic vesicle docking and priming, Caenorhabditis elegans"
xref: Reactome:REACT_115054 "release of L-Glutamate at the synapse, Xenopus tropicalis"
xref: Reactome:REACT_115130 "Acetylcholine synaptic vesicle docking and priming, Gallus gallus"
xref: Reactome:REACT_115353 "Release of acetylcholine at the synapse, Xenopus tropicalis"
xref: Reactome:REACT_12411 "release of L-Glutamate at the synapse, Homo sapiens"
xref: Reactome:REACT_12617 "Glutamate synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_14778 "Vamp7 associated Lysosome to Plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_14821 "Vamp8 associated secretory vesicle to plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_14822 "Vamp2 associated secretory vesicle to plasma membrane transport, Homo sapiens"
xref: Reactome:REACT_15326 "Exocytosis of Insulin, Homo sapiens"
xref: Reactome:REACT_15338 "Serotonin loaded synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15404 "Release of acetylcholine at the synapse, Homo sapiens"
xref: Reactome:REACT_15411 "Noradrenalin synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15448 "Release of noradrenaline at the synapse, Homo sapiens"
xref: Reactome:REACT_15483 "Acetylcholine synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15503 "Release of docked serotonin loaded synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_15517 "Dopamine synaptic vesicle docking and priming, Homo sapiens"
xref: Reactome:REACT_15533 "Release of docked dopamine loaded synaptic vesicle, Homo sapiens"
xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens"
xref: Reactome:REACT_23813 "Release of GABA at the synapse, Homo sapiens"
xref: Reactome:REACT_23973 "GABA loaded synaptic vesicle Docking and Priming, Homo sapiens"
xref: Reactome:REACT_29535 "Acetylcholine synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_31215 "Exocytosis of Insulin, Rattus norvegicus"
xref: Reactome:REACT_31588 "Vamp2 associated secretory vesicle to plasma membrane transport, Danio rerio"
xref: Reactome:REACT_34035 "Vamp2 associated secretory vesicle to plasma membrane transport, Mus musculus"
xref: Reactome:REACT_77361 "Vamp2 associated secretory vesicle to plasma membrane transport, Sus scrofa"
xref: Reactome:REACT_77506 "Glutamate synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_77785 "Vamp7 associated Lysosome to Plasma membrane transport, Danio rerio"
xref: Reactome:REACT_77831 "release of L-Glutamate at the synapse, Mus musculus"
xref: Reactome:REACT_79299 "Glutamate synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_80371 "Vamp2 associated secretory vesicle to plasma membrane transport, Bos taurus"
xref: Reactome:REACT_82023 "Acetylcholine synaptic vesicle docking and priming, Mus musculus"
xref: Reactome:REACT_82703 "Vamp7 associated Lysosome to Plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_83226 "Glutamate synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_84308 "Release of noradrenaline at the synapse, Canis familiaris"
xref: Reactome:REACT_84628 "Exocytosis of Insulin, Xenopus tropicalis"
xref: Reactome:REACT_87193 "Glutamate synaptic vesicle docking and priming, Canis familiaris"
xref: Reactome:REACT_87411 "Vamp8 associated secretory vesicle to plasma membrane transport, Canis familiaris"
xref: Reactome:REACT_87768 "Vamp2 associated secretory vesicle to plasma membrane transport, Xenopus tropicalis"
xref: Reactome:REACT_90536 "Vamp7 associated Lysosome to Plasma membrane transport, Arabidopsis thaliana"
xref: Reactome:REACT_92466 "Vamp8 associated secretory vesicle to plasma membrane transport, Bos taurus"
xref: Reactome:REACT_93575 "Release of acetylcholine at the synapse, Rattus norvegicus"
xref: Reactome:REACT_93655 "Release of acetylcholine at the synapse, Canis familiaris"
xref: Reactome:REACT_93705 "Noradrenalin synaptic vesicle docking and priming, Rattus norvegicus"
xref: Reactome:REACT_94126 "Vamp8 associated secretory vesicle to plasma membrane transport, Danio rerio"
xref: Reactome:REACT_94434 "Exocytosis of Insulin, Bos taurus"
xref: Reactome:REACT_95323 "Vamp7 associated Lysosome to Plasma membrane transport, Oryza sativa"
xref: Reactome:REACT_96543 "Glutamate synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_96609 "release of L-Glutamate at the synapse, Rattus norvegicus"
xref: Reactome:REACT_96753 "Acetylcholine synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_96842 "Vamp8 associated secretory vesicle to plasma membrane transport, Mus musculus"
xref: Reactome:REACT_97101 "Exocytosis of Insulin, Canis familiaris"
xref: Reactome:REACT_98480 "Noradrenalin synaptic vesicle docking and priming, Xenopus tropicalis"
xref: Reactome:REACT_98819 "Noradrenalin synaptic vesicle docking and priming, Danio rerio"
xref: Reactome:REACT_99501 "Release of noradrenaline at the synapse, Mus musculus"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0000150
name: recombinase activity
namespace: molecular_function
def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]
comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
subset: gosubset_prok
synonym: "strand transferase" NARROW []
xref: Reactome:REACT_27300 "Formation of Meiotic Heteroduplex, Homo sapiens"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000152
name: nuclear ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000153
name: cytoplasmic ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000154
name: rRNA modification
namespace: biological_process
alt_id: GO:0016548
def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "rRNA editing" NARROW [GOC:hjd]
is_a: GO:0006364 ! rRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0000155
name: two-component sensor activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]
subset: gosubset_prok
synonym: "two-component sensor molecule" NARROW []
synonym: "two-component system sensor activity " EXACT []
xref: EC:2.7.3.-
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0000160 ! two-component signal transduction system (phosphorelay)
relationship: part_of GO:0023014 ! signal transduction by phosphorylation

[Term]
id: GO:0000156
name: two-component response regulator activity
namespace: molecular_function
def: "Responds to a two-component sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140]
subset: goslim_metagenomics
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity
relationship: part_of GO:0000160 ! two-component signal transduction system (phosphorelay)
relationship: part_of GO:0035556 ! intracellular signal transduction

[Term]
id: GO:0000159
name: protein phosphatase type 2A complex
namespace: cellular_component
def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000160
name: two-component signal transduction system (phosphorelay)
namespace: biological_process
def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]
subset: goslim_metagenomics
subset: gosubset_prok
synonym: "histidyl-aspartyl phosphorelay" EXACT []
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0000161
name: MAPK cascade involved in osmosensory signaling pathway
namespace: biological_process
def: "A MAPK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267]
synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736]
synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736]
synonym: "MAPKKK cascade during osmolarity sensing" EXACT []
synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling]
synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, MAPKKK cascade" EXACT []
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0007231 ! osmosensory signaling pathway
relationship: part_of GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0000162
name: tryptophan biosynthetic process
namespace: biological_process
alt_id: GO:0009096
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY]
subset: gosubset_prok
synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT []
synonym: "tryptophan anabolism" EXACT []
synonym: "tryptophan biosynthesis" EXACT []
synonym: "tryptophan formation" EXACT []
synonym: "tryptophan synthesis" EXACT []
xref: MetaCyc:TRPSYN-PWY
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process

[Term]
id: GO:0000164
name: protein phosphatase type 1 complex
namespace: cellular_component
def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000165
name: MAPK cascade
namespace: biological_process
def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
synonym: "ERK/MAPK cascade" NARROW []
synonym: "MAP kinase cascade" EXACT []
synonym: "MAP kinase kinase kinase cascade" EXACT []
synonym: "MAPK signaling" RELATED []
synonym: "MAPK signalling" RELATED []
synonym: "MAPKKK cascade" EXACT [GOC:curators]
synonym: "MAPKKK cascade during sporulation" NARROW []
synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf]
xref: Reactome:REACT_101634 "RAF/MAP kinase cascade, Bos taurus"
xref: Reactome:REACT_107261 "RAF/MAP kinase cascade, Saccharomyces cerevisiae"
xref: Reactome:REACT_107863 "RAF/MAP kinase cascade, Canis familiaris"
xref: Reactome:REACT_108330 "RAF/MAP kinase cascade, Xenopus tropicalis"
xref: Reactome:REACT_112235 "RAF/MAP kinase cascade, Dictyostelium discoideum"
xref: Reactome:REACT_112942 "RAF/MAP kinase cascade, Arabidopsis thaliana"
xref: Reactome:REACT_113285 "RAF/MAP kinase cascade, Oryza sativa"
xref: Reactome:REACT_634 "RAF/MAP kinase cascade, Homo sapiens"
xref: Reactome:REACT_79658 "RAF/MAP kinase cascade, Schizosaccharomyces pombe"
xref: Reactome:REACT_85806 "RAF/MAP kinase cascade, Drosophila melanogaster"
xref: Reactome:REACT_87028 "RAF/MAP kinase cascade, Danio rerio"
xref: Reactome:REACT_87232 "RAF/MAP kinase cascade, Mus musculus"
xref: Reactome:REACT_87855 "RAF/MAP kinase cascade, Rattus norvegicus"
xref: Reactome:REACT_92078 "RAF/MAP kinase cascade, Sus scrofa"
xref: Reactome:REACT_92987 "RAF/MAP kinase cascade, Caenorhabditis elegans"
xref: Reactome:REACT_94585 "RAF/MAP kinase cascade, Taeniopygia guttata"
xref: Reactome:REACT_94805 "RAF/MAP kinase cascade, Gallus gallus"
xref: Wikipedia:MAPK_cascade
xref: Wikipedia:Mitogen-activated_protein_kinase
is_a: GO:0007243 ! intracellular protein kinase cascade

[Term]
id: GO:0000166
name: nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0000167
name: activation of MAPKKK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038081 ! MAP kinase kinase kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038081 ! MAP kinase kinase kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000168
name: activation of MAPKK activity involved in osmosensory signaling pathway
namespace: biological_process
alt_id: GO:0007233
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "activation of Pbs2 kinase" NARROW []
synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038080 ! MAP kinase kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038080 ! MAP kinase kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000169
name: activation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAPK activity during osmolarity sensing" EXACT []
synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway
relationship: positively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000170
name: sphingosine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590]
xref: Reactome:REACT_100351 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Danio rerio"
xref: Reactome:REACT_103503 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus"
xref: Reactome:REACT_104963 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Canis familiaris"
xref: Reactome:REACT_115687 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Gallus gallus"
xref: Reactome:REACT_19258 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Homo sapiens"
xref: Reactome:REACT_29940 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Oryza sativa"
xref: Reactome:REACT_31871 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Drosophila melanogaster"
xref: Reactome:REACT_80095 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Bos taurus"
xref: Reactome:REACT_82371 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Xenopus tropicalis"
xref: Reactome:REACT_85471 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Dictyostelium discoideum"
xref: Reactome:REACT_85651 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Sus scrofa"
xref: Reactome:REACT_86222 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Arabidopsis thaliana"
xref: Reactome:REACT_91283 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Schizosaccharomyces pombe"
xref: Reactome:REACT_92284 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Rattus norvegicus"
xref: Reactome:REACT_96037 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Taeniopygia guttata"
xref: Reactome:REACT_97092 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Caenorhabditis elegans"
xref: Reactome:REACT_99475 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O, Mus musculus"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0000171
name: ribonuclease MRP activity
namespace: molecular_function
def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380]
synonym: "RNase MRP" EXACT []
xref: Wikipedia:RNase_MRP
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0000172
name: ribonuclease MRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]
synonym: "ribonuclease mitochondrial RNA processing complex" EXACT []
synonym: "RNase MRP complex" EXACT []
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex

[Term]
id: GO:0000173
name: inactivation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267]
synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT []
synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "osmolarity sensing, inactivation of MAPK" EXACT []
synonym: "osmolarity sensing, termination of MAPK activity" EXACT []
synonym: "termination of MAPK activity during osmolarity sensing" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007231 ! osmosensory signaling pathway
relationship: negatively_regulates GO:0038079 ! MAP kinase activity involved in osmosensory signaling pathway

[Term]
id: GO:0000174
name: inactivation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0000175
name: 3'-5'-exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "3'-5' exoribonuclease activity" EXACT []
xref: EC:3.1.13.-
xref: Reactome:REACT_102966 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_108214 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Sus scrofa"
xref: Reactome:REACT_20588 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Homo sapiens"
xref: Reactome:REACT_33991 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Dictyostelium discoideum"
xref: Reactome:REACT_34078 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Danio rerio"
xref: Reactome:REACT_78363 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Bos taurus"
xref: Reactome:REACT_82118 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Rattus norvegicus"
xref: Reactome:REACT_88115 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Arabidopsis thaliana"
xref: Reactome:REACT_89880 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Oryza sativa"
xref: Reactome:REACT_92153 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Caenorhabditis elegans"
xref: Reactome:REACT_93499 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Drosophila melanogaster"
xref: Reactome:REACT_95913 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Canis familiaris"
xref: Reactome:REACT_95921 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Mus musculus"
xref: Reactome:REACT_96267 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Taeniopygia guttata"
xref: Reactome:REACT_99422 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Xenopus tropicalis"
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0000176
name: nuclear exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT []
synonym: "nuclear exosome (ribonuclease complex)" EXACT []
synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000178 ! exosome (RNase complex)
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000177
name: cytoplasmic exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791]
synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT []
synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT []
synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000178 ! exosome (RNase complex)
intersection_of: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases." [PMID:10465791]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subset: goslim_pir
synonym: "exosome (ribonucleasease complex)" EXACT []
synonym: "exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000179
name: rRNA (adenine-N6,N6-)-dimethyltransferase activity
namespace: molecular_function
alt_id: GO:0043790
def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410]
subset: gosubset_prok
synonym: "18S rRNA dimethylase activity" EXACT []
synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532]
synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0000180
name: cytosolic large ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
is_obsolete: true
consider: GO:0022625

[Term]
id: GO:0000181
name: cytosolic small ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
is_obsolete: true
consider: GO:0022627

[Term]
id: GO:0000182
name: rDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
synonym: "ribosomal DNA binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0000183
name: chromatin silencing at rDNA
namespace: biological_process
def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245]
synonym: "chromatin silencing at ribosomal DNA" EXACT []
synonym: "heterochromatic silencing at rDNA" EXACT []
synonym: "rDNA chromatin silencing" EXACT [GOC:mah]
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0000184
name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
synonym: "mRNA breakdown, nonsense-mediated decay" EXACT []
synonym: "mRNA catabolic process, nonsense-mediated" EXACT []
synonym: "mRNA catabolism, nonsense-mediated" EXACT []
synonym: "mRNA degradation, nonsense-mediated decay" EXACT []
synonym: "nonsense-mediated mRNA decay" EXACT []
synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT []
xref: Reactome:REACT_75886 "Nonsense-Mediated Decay, Homo sapiens"
xref: Wikipedia:Nonsense-mediated_decay
xref: Wikipedia:Nonsense-mediated_mRNA_decay
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000185
name: activation of MAPKKK activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase" EXACT []
synonym: "activation of MAP3K activity" EXACT [GOC:bf]
synonym: "activation of MAPKKK activity during sporulation" NARROW []
synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD []
synonym: "positive regulation of MAPKKK activity" BROAD []
is_a: GO:0032147 ! activation of protein kinase activity
relationship: positively_regulates GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0000186
name: activation of MAPKK activity
namespace: biological_process
alt_id: GO:0007255
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity" EXACT []
synonym: "activation of MAP/ERK kinase kinase" EXACT []
synonym: "activation of MAP2K activity" EXACT [GOC:bf]
synonym: "activation of MAPKK activity during sporulation" NARROW []
synonym: "positive regulation of MAPKK activity" BROAD []
xref: Reactome:REACT_101798 "Prolonged ERK activation events, Mus musculus"
xref: Reactome:REACT_102728 "Prolonged ERK activation events, Schizosaccharomyces pombe"
xref: Reactome:REACT_103900 "Prolonged ERK activation events, Gallus gallus"
xref: Reactome:REACT_104177 "MEK activation, Danio rerio"
xref: Reactome:REACT_104271 "Prolonged ERK activation events, Canis familiaris"
xref: Reactome:REACT_110634 "MEK activation, Canis familiaris"
xref: Reactome:REACT_113771 "Prolonged ERK activation events, Arabidopsis thaliana"
xref: Reactome:REACT_114228 "Prolonged ERK activation events, Dictyostelium discoideum"
xref: Reactome:REACT_114817 "Prolonged ERK activation events, Oryza sativa"
xref: Reactome:REACT_12005 "Prolonged ERK activation events, Homo sapiens"
xref: Reactome:REACT_33773 "Prolonged ERK activation events, Caenorhabditis elegans"
xref: Reactome:REACT_81505 "MEK activation, Gallus gallus"
xref: Reactome:REACT_81553 "Prolonged ERK activation events, Xenopus tropicalis"
xref: Reactome:REACT_82861 "MEK activation, Xenopus tropicalis"
xref: Reactome:REACT_86719 "Prolonged ERK activation events, Rattus norvegicus"
xref: Reactome:REACT_86891 "Prolonged ERK activation events, Bos taurus"
xref: Reactome:REACT_87045 "Prolonged ERK activation events, Taeniopygia guttata"
xref: Reactome:REACT_89175 "Prolonged ERK activation events, Danio rerio"
xref: Reactome:REACT_89555 "MEK activation, Bos taurus"
xref: Reactome:REACT_91625 "Prolonged ERK activation events, Drosophila melanogaster"
xref: Reactome:REACT_94138 "Prolonged ERK activation events, Sus scrofa"
xref: Reactome:REACT_94626 "MEK activation, Mus musculus"
xref: Reactome:REACT_95763 "MEK activation, Taeniopygia guttata"
xref: Reactome:REACT_962 "MEK activation, Homo sapiens"
xref: Reactome:REACT_97271 "Prolonged ERK activation events, Saccharomyces cerevisiae"
xref: Reactome:REACT_98727 "MEK activation, Rattus norvegicus"
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
relationship: positively_regulates GO:0004708 ! MAP kinase kinase activity

[Term]
id: GO:0000187
name: activation of MAPK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267]
synonym: "activation of MAP kinase" EXACT []
synonym: "activation of MAPK activity during sporulation" NARROW []
synonym: "MAPK activation" EXACT []
xref: Reactome:REACT_100881 "activated TAK1 mediates p38 MAPK activation, Canis familiaris"
xref: Reactome:REACT_101870 "ERK activation, Caenorhabditis elegans"
xref: Reactome:REACT_101978 "ERK activation, Drosophila melanogaster"
xref: Reactome:REACT_102664 "activated TAK1 mediates p38 MAPK activation, Caenorhabditis elegans"
xref: Reactome:REACT_102813 "activated TAK1 mediates p38 MAPK activation, Arabidopsis thaliana"
xref: Reactome:REACT_103235 "ERK activation, Sus scrofa"
xref: Reactome:REACT_103251 "activated TAK1 mediates p38 MAPK activation, Dictyostelium discoideum"
xref: Reactome:REACT_106101 "ERK activation, Bos taurus"
xref: Reactome:REACT_112664 "ERK activation, Oryza sativa"
xref: Reactome:REACT_113767 "ERK activation, Dictyostelium discoideum"
xref: Reactome:REACT_114778 "ERK activation, Arabidopsis thaliana"
xref: Reactome:REACT_1482 "ERK activation, Homo sapiens"
xref: Reactome:REACT_21399 "activated TAK1 mediates p38 MAPK activation, Homo sapiens"
xref: Reactome:REACT_25355 "MAPK activation in TLR cascade, Gallus gallus"
xref: Reactome:REACT_25370 "Activated TAK1 mediates p38 MAP kinase phosphorylation, Gallus gallus"
xref: Reactome:REACT_28684 "ERK activation, Gallus gallus"
xref: Reactome:REACT_29727 "activated TAK1 mediates p38 MAPK activation, Xenopus tropicalis"
xref: Reactome:REACT_30502 "ERK activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_32301 "activated TAK1 mediates p38 MAPK activation, Rattus norvegicus"
xref: Reactome:REACT_34590 "ERK activation, Rattus norvegicus"
xref: Reactome:REACT_77440 "activated TAK1 mediates p38 MAPK activation, Mus musculus"
xref: Reactome:REACT_77987 "ERK activation, Taeniopygia guttata"
xref: Reactome:REACT_78017 "activated TAK1 mediates p38 MAPK activation, Bos taurus"
xref: Reactome:REACT_83894 "activated TAK1 mediates p38 MAPK activation, Sus scrofa"
xref: Reactome:REACT_84937 "ERK activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_86273 "activated TAK1 mediates p38 MAPK activation, Taeniopygia guttata"
xref: Reactome:REACT_86655 "activated TAK1 mediates p38 MAPK activation, Danio rerio"
xref: Reactome:REACT_87442 "activated TAK1 mediates p38 MAPK activation, Drosophila melanogaster"
xref: Reactome:REACT_88492 "ERK activation, Canis familiaris"
xref: Reactome:REACT_88606 "ERK activation, Mus musculus"
xref: Reactome:REACT_91962 "activated TAK1 mediates p38 MAPK activation, Oryza sativa"
xref: Reactome:REACT_93371 "activated TAK1 mediates p38 MAPK activation, Gallus gallus"
xref: Reactome:REACT_98123 "ERK activation, Xenopus tropicalis"
xref: Reactome:REACT_99633 "ERK activation, Danio rerio"
is_a: GO:0006468 ! protein phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043406 ! positive regulation of MAP kinase activity

[Term]
id: GO:0000188
name: inactivation of MAPK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267]
synonym: "inactivation of MAPK during sporulation" NARROW []
synonym: "termination of MAPK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity
relationship: part_of GO:0043409 ! negative regulation of MAPK cascade

[Term]
id: GO:0000189
name: MAPK import into nucleus
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "nuclear translocation of MAPK" NARROW [GOC:mah]
xref: Reactome:REACT_103042 "Nuclear translocation of phospho-ERK-1 dimer, Schizosaccharomyces pombe"
xref: Reactome:REACT_105886 "Nuclear translocation of phospho-ERK-2 dimer, Gallus gallus"
xref: Reactome:REACT_106064 "Nuclear translocation of phospho-ERK-2 dimer, Mus musculus"
xref: Reactome:REACT_107045 "Nuclear translocation of phospho-ERK-1 dimer, Canis familiaris"
xref: Reactome:REACT_110766 "Nuclear translocation of phospho-ERK-1 dimer, Danio rerio"
xref: Reactome:REACT_113196 "Nuclear translocation of phospho-ERK-1 dimer, Oryza sativa"
xref: Reactome:REACT_114932 "Nuclear translocation of phospho-ERK-1 dimer, Dictyostelium discoideum"
xref: Reactome:REACT_115101 "Nuclear translocation of phospho-ERK-1 dimer, Arabidopsis thaliana"
xref: Reactome:REACT_1866 "Nuclear translocation of phospho-ERK-1 dimer, Homo sapiens"
xref: Reactome:REACT_29004 "Nuclear translocation of phospho-ERK-1 dimer, Caenorhabditis elegans"
xref: Reactome:REACT_32259 "Nuclear translocation of phospho-ERK-1 dimer, Saccharomyces cerevisiae"
xref: Reactome:REACT_33595 "Nuclear translocation of phospho-ERK-1 dimer, Mus musculus"
xref: Reactome:REACT_487 "Nuclear translocation of phospho-ERK-2 dimer, Homo sapiens"
xref: Reactome:REACT_510 "Nuclear translocation of phospho-ERK-2 dimer, Rattus norvegicus"
xref: Reactome:REACT_78269 "Nuclear translocation of phospho-ERK-2 dimer, Danio rerio"
xref: Reactome:REACT_79422 "Nuclear translocation of phospho-ERK-2 dimer, Bos taurus"
xref: Reactome:REACT_81446 "Nuclear translocation of phospho-ERK-2 dimer, Taeniopygia guttata"
xref: Reactome:REACT_87335 "Nuclear translocation of phospho-ERK-2 dimer, Xenopus tropicalis"
xref: Reactome:REACT_89933 "Nuclear translocation of phospho-ERK-1 dimer, Drosophila melanogaster"
xref: Reactome:REACT_94910 "Nuclear translocation of phospho-ERK-1 dimer, Bos taurus"
xref: Reactome:REACT_95119 "Nuclear translocation of phospho-ERK-2 dimer, Sus scrofa"
xref: Reactome:REACT_97762 "Nuclear translocation of phospho-ERK-2 dimer, Canis familiaris"
is_a: GO:0006606 ! protein import into nucleus
relationship: part_of GO:0000165 ! MAPK cascade

[Term]
id: GO:0000190
name: MAPKKK cascade (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000191
name: activation of MAPKKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000192
name: activation of MAPKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000193
name: activation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000194
name: inactivation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000195
name: nuclear translocation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000196
name: MAPK cascade involved in cell wall biogenesis
namespace: biological_process
def: "A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, MAPKKK cascade" EXACT []
synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling]
synonym: "Mpk1 cascade" NARROW [PMID:10523653]
synonym: "Slt2 cascade" NARROW [PMID:10523653]
is_a: GO:0000165 ! MAPK cascade
intersection_of: GO:0000165 ! MAPK cascade
intersection_of: part_of GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0000197
name: activation of MAPKKK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038070 ! MAP kinase kinase kinase activity involved in cell wall biogenesis
relationship: positively_regulates GO:0038070 ! MAP kinase kinase kinase activity involved in cell wall biogenesis

[Term]
id: GO:0000198
name: activation of MAPKK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038068 ! MAP kinase kinase activity involved in cell wall biogenesis
relationship: positively_regulates GO:0038068 ! MAP kinase kinase activity involved in cell wall biogenesis

[Term]
id: GO:0000199
name: activation of MAPK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "cell wall biogenesis, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0038067 ! MAP kinase activity involved in cell wall biogenesis
relationship: positively_regulates GO:0038067 ! MAP kinase activity involved in cell wall biogenesis

[Term]
id: GO:0000200
name: inactivation of MAPK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT []
synonym: "cell wall biogenesis, termination of MAPK activity" EXACT []
synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf]
synonym: "termination of MAPK activity during cell wall biogenesis" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0038067 ! MAP kinase activity involved in cell wall biogenesis
relationship: negatively_regulates GO:0038067 ! MAP kinase activity involved in cell wall biogenesis

[Term]
id: GO:0000201
name: MAPK import into nucleus involved in cell wall biogenesis
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah]
synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0000196 ! MAPK cascade involved in cell wall biogenesis

[Term]
id: GO:0000202
name: MAPKKK cascade during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000203
name: activation of MAPKKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000204
name: activation of MAPKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000205
name: activation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000206
name: inactivation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000207
name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000208
name: MAPK import into nucleus involved in osmosensory signaling pathway
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267]
synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah]
synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah]
synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT []
synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah]
synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah]
synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah]
synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah]
is_a: GO:0000189 ! MAPK import into nucleus
intersection_of: GO:0000189 ! MAPK import into nucleus
intersection_of: part_of GO:0007231 ! osmosensory signaling pathway
relationship: part_of GO:0000161 ! MAPK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000209
name: protein polyubiquitination
namespace: biological_process
def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194]
synonym: "polyubiquitin" RELATED []
synonym: "protein polyubiquitinylation" EXACT []
synonym: "protein polyubiquitylation" EXACT []
xref: Reactome:REACT_75842 "Antigen processing: Ubiquitination & Proteasome degradation, Homo sapiens"
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0000210
name: NAD+ diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22]
subset: gosubset_prok
synonym: "NAD diphosphatase activity" EXACT []
synonym: "NAD pyrophosphatase activity" EXACT []
synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22]
synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22]
synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22]
xref: EC:3.6.1.22
xref: MetaCyc:NADPYROPHOSPHAT-RXN
xref: RHEA:11803
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0000211
name: protein degradation tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194]
comment: This term was made obsolete because it represents a biological process and a molecular function.
is_obsolete: true
consider: GO:0005515
consider: GO:0019941
consider: GO:0042787

[Term]
id: GO:0000212
name: meiotic spindle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
synonym: "meiotic spindle organisation" EXACT [GOC:curators]
synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "spindle organization during meiosis" EXACT [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0007051 ! spindle organization
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000213
name: tRNA-intron endonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA-intron endoribonuclease activity" EXACT []
synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9]
xref: EC:3.1.27.9
xref: MetaCyc:3.1.27.9-RXN
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0000214
name: tRNA-intron endonuclease complex
namespace: cellular_component
def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
synonym: "SEN complex" EXACT [GOC:se, PMID:22391451]
synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000215
name: tRNA 2'-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937]
synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "Tpt1" RELATED [EC:2.7.1.160]
synonym: "Tpt1p" RELATED [EC:2.7.1.160]
synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160]
xref: EC:2.7.1.160
xref: MetaCyc:2.7.1.160-RXN
is_a: GO:0008665 ! 2'-phosphotransferase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0000216
name: M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:REACT_103126 "M/G1 Transition, Sus scrofa"
xref: Reactome:REACT_103368 "M/G1 Transition, Taeniopygia guttata"
xref: Reactome:REACT_105126 "M/G1 Transition, Caenorhabditis elegans"
xref: Reactome:REACT_108209 "M/G1 Transition, Schizosaccharomyces pombe"
xref: Reactome:REACT_108301 "M/G1 Transition, Saccharomyces cerevisiae"
xref: Reactome:REACT_109437 "M/G1 Transition, Rattus norvegicus"
xref: Reactome:REACT_110954 "M/G1 Transition, Dictyostelium discoideum"
xref: Reactome:REACT_1725 "M/G1 Transition, Homo sapiens"
xref: Reactome:REACT_32146 "M/G1 Transition, Arabidopsis thaliana"
xref: Reactome:REACT_32196 "M/G1 Transition, Plasmodium falciparum"
xref: Reactome:REACT_77227 "M/G1 Transition, Danio rerio"
xref: Reactome:REACT_77394 "M/G1 Transition, Mus musculus"
xref: Reactome:REACT_78459 "M/G1 Transition, Gallus gallus"
xref: Reactome:REACT_79481 "M/G1 Transition, Drosophila melanogaster"
xref: Reactome:REACT_83776 "M/G1 Transition, Oryza sativa"
xref: Reactome:REACT_86397 "M/G1 Transition, Canis familiaris"
xref: Reactome:REACT_89032 "M/G1 Transition, Xenopus tropicalis"
xref: Reactome:REACT_94915 "M/G1 Transition, Bos taurus"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000217
name: DNA secondary structure binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0000219
name: vacuolar hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "V-ATPase" EXACT []
is_obsolete: true
consider: GO:0016469

[Term]
id: GO:0000220
name: vacuolar proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000221
name: vacuolar proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain generally consists of eight subunits.
synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
intersection_of: part_of GO:0005773 ! vacuole
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000222
name: plasma membrane proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0044459 ! plasma membrane part
intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005887 ! integral to plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000223
name: plasma membrane proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0044459 ! plasma membrane part
intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
intersection_of: part_of GO:0005886 ! plasma membrane
relationship: part_of GO:0005887 ! integral to plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000224
name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]
subset: gosubset_prok
synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52]
synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52]
synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52]
synonym: "N-glycanase activity" RELATED [EC:3.5.1.52]
synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52]
synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52]
synonym: "peptide:N-glycanase" RELATED []
synonym: "PNGase" EXACT []
synonym: "PNGase A" RELATED [EC:3.5.1.52]
synonym: "PNGase F" RELATED [EC:3.5.1.52]
xref: EC:3.5.1.52
xref: MetaCyc:3.5.1.52-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0000225
name: N-acetylglucosaminylphosphatidylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89]
comment: Note that this function was formerly EC:3.1.1.69.
synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89]
xref: EC:3.5.1.89
xref: MetaCyc:3.1.1.69-RXN
xref: Reactome:REACT_100003 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Gallus gallus"
xref: Reactome:REACT_103061 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Taeniopygia guttata"
xref: Reactome:REACT_107021 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Caenorhabditis elegans"
xref: Reactome:REACT_111009 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Dictyostelium discoideum"
xref: Reactome:REACT_114989 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Arabidopsis thaliana"
xref: Reactome:REACT_29732 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Schizosaccharomyces pombe"
xref: Reactome:REACT_32276 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Saccharomyces cerevisiae"
xref: Reactome:REACT_33502 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Bos taurus"
xref: Reactome:REACT_33809 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Drosophila melanogaster"
xref: Reactome:REACT_77843 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Danio rerio"
xref: Reactome:REACT_779 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Homo sapiens"
xref: Reactome:REACT_82306 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Oryza sativa"
xref: Reactome:REACT_82765 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Mus musculus"
xref: Reactome:REACT_88022 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Plasmodium falciparum"
xref: Reactome:REACT_88604 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Canis familiaris"
xref: Reactome:REACT_91074 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Rattus norvegicus"
xref: Reactome:REACT_98776 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate, Sus scrofa"
xref: RHEA:11663
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0000227
name: oxaloacetate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "oxaloacetate carrier activity" RELATED []
is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0000229
name: cytoplasmic chromosome
namespace: cellular_component
def: "A chromosome found in the cytoplasm." [GOC:mah]
subset: goslim_generic
subset: gosubset_prok
synonym: "cytoplasmic interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000230
name: nuclear mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0000231
name: cytoplasmic mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000793

[Term]
id: GO:0000232
name: nuclear interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000228

[Term]
id: GO:0000233
name: cytoplasmic interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000229

[Term]
id: GO:0000234
name: phosphoethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103]
synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103]
synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103]
xref: EC:2.1.1.103
xref: KEGG:R02037
xref: MetaCyc:2.1.1.103-RXN
xref: RHEA:20366
xref: RHEA:20368
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000235
name: astral microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
is_a: GO:0005876 ! spindle microtubule
is_a: GO:0005881 ! cytoplasmic microtubule
intersection_of: GO:0005876 ! spindle microtubule
intersection_of: part_of GO:0005818 ! aster
relationship: part_of GO:0005818 ! aster

[Term]
id: GO:0000236
name: mitotic prometaphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Reactome:REACT_102823 "Mitotic Prometaphase, Mus musculus"
xref: Reactome:REACT_104270 "Mitotic Prometaphase, Bos taurus"
xref: Reactome:REACT_105082 "Mitotic Prometaphase, Dictyostelium discoideum"
xref: Reactome:REACT_114704 "Mitotic Prometaphase, Schizosaccharomyces pombe"
xref: Reactome:REACT_118069 "Mitotic Prometaphase, Gallus gallus"
xref: Reactome:REACT_118526 "Mitotic Prometaphase, Saccharomyces cerevisiae"
xref: Reactome:REACT_118539 "Mitotic Prometaphase, Taeniopygia guttata"
xref: Reactome:REACT_31336 "Mitotic Prometaphase, Danio rerio"
xref: Reactome:REACT_31385 "Mitotic Prometaphase, Caenorhabditis elegans"
xref: Reactome:REACT_682 "Mitotic Prometaphase, Homo sapiens"
xref: Reactome:REACT_79351 "Mitotic Prometaphase, Rattus norvegicus"
xref: Reactome:REACT_83126 "Mitotic Prometaphase, Drosophila melanogaster"
xref: Reactome:REACT_98905 "Mitotic Prometaphase, Xenopus tropicalis"
xref: Reactome:REACT_99376 "Mitotic Prometaphase, Canis familiaris"
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000237
name: leptotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Leptotene
xref: Wikipedia:Meiosis#Leptotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000238
name: zygotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Zygotene
xref: Wikipedia:Zygotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000239
name: pachytene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Pachytene
xref: Wikipedia:Pachytene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000240
name: diplotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Diplotene
xref: Wikipedia:Meiosis#Diplotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000241
name: diakinesis
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Diakinesis
xref: Wikipedia:Meiosis#Diakinesis
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000242
name: pericentriolar material
namespace: cellular_component
def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0000243
name: commitment complex
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140]
synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah]
synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
relationship: has_part GO:0005685 ! U1 snRNP

[Term]
id: GO:0000244
name: assembly of spliceosomal tri-snRNP
namespace: biological_process
alt_id: GO:0000351
alt_id: GO:0000355
def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]
synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW []
synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW []
synonym: "snRNP recycling" BROAD []
synonym: "spliceosomal tri-snRNP assembly" EXACT []
synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW []
synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000387 ! spliceosomal snRNP assembly

[Term]
id: GO:0000245
name: spliceosomal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
synonym: "spliceosome assembly" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000246
name: delta24(24-1) sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18504]
subset: gosubset_prok
synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "D24(24-1)-sterol reductase activity" EXACT []
synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta-24(28) methylene reductase activity" EXACT []
synonym: "sterol delta-24(28) reductase activity" EXACT []
synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71]
xref: EC:1.3.1.71
xref: KEGG:R05641
xref: MetaCyc:1.3.1.71-RXN
xref: RHEA:18504
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000247
name: C-8 sterol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026]
synonym: "delta-8-delta-7 sterol isomerase activity" EXACT []
xref: EC:5.3.3.-
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0000248
name: C-5 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
synonym: "sterol-C5-desaturase activity" EXACT []
xref: Reactome:REACT_10092 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_106801 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_108498 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_110659 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Bos taurus"
xref: Reactome:REACT_34122 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Danio rerio"
xref: Reactome:REACT_34697 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_79598 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Mus musculus"
xref: Reactome:REACT_84206 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_85577 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_86700 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_98513 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol, Schizosaccharomyces pombe"
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000249
name: C-22 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000250
name: lanosterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14624]
subset: gosubset_prok
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT []
synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7]
synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7]
synonym: "OSC" EXACT []
synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "oxidosqualene-lanosterol cyclase activity" EXACT []
synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7]
synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
xref: EC:5.4.99.7
xref: KEGG:R03199
xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN
xref: Reactome:REACT_106250 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Danio rerio"
xref: Reactome:REACT_112890 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Oryza sativa"
xref: Reactome:REACT_114747 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Arabidopsis thaliana"
xref: Reactome:REACT_29522 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Schizosaccharomyces pombe"
xref: Reactome:REACT_33379 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Xenopus tropicalis"
xref: Reactome:REACT_78122 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Taeniopygia guttata"
xref: Reactome:REACT_84749 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Bos taurus"
xref: Reactome:REACT_86645 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Saccharomyces cerevisiae"
xref: Reactome:REACT_88346 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Rattus norvegicus"
xref: Reactome:REACT_89548 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Gallus gallus"
xref: Reactome:REACT_92166 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Dictyostelium discoideum"
xref: Reactome:REACT_93681 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Canis familiaris"
xref: Reactome:REACT_9391 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Homo sapiens"
xref: Reactome:REACT_96289 "Squalene 2,3-epoxide cyclizes, forming lanosterol, Mus musculus"
xref: RHEA:14624
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0000252
name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT []
synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED []
synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED []
synonym: "C-3 sterol dehydrogenase activity" RELATED []
synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED []
synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED []
synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED []
xref: EC:1.1.1.-
xref: Reactome:REACT_10053 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Homo sapiens"
xref: Reactome:REACT_103278 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Sus scrofa"
xref: Reactome:REACT_103729 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Bos taurus"
xref: Reactome:REACT_105643 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Gallus gallus"
xref: Reactome:REACT_106602 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Bos taurus"
xref: Reactome:REACT_107465 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Canis familiaris"
xref: Reactome:REACT_108692 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Mus musculus"
xref: Reactome:REACT_108789 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Rattus norvegicus"
xref: Reactome:REACT_109155 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Danio rerio"
xref: Reactome:REACT_112688 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_112771 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Escherichia coli"
xref: Reactome:REACT_112854 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Schizosaccharomyces pombe"
xref: Reactome:REACT_112960 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Saccharomyces cerevisiae"
xref: Reactome:REACT_112995 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Schizosaccharomyces pombe"
xref: Reactome:REACT_113072 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Oryza sativa"
xref: Reactome:REACT_113373 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Dictyostelium discoideum"
xref: Reactome:REACT_113553 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Saccharomyces cerevisiae"
xref: Reactome:REACT_114106 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Oryza sativa"
xref: Reactome:REACT_114356 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Dictyostelium discoideum"
xref: Reactome:REACT_115015 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Arabidopsis thaliana"
xref: Reactome:REACT_115441 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Arabidopsis thaliana"
xref: Reactome:REACT_30127 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Rattus norvegicus"
xref: Reactome:REACT_31080 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Taeniopygia guttata"
xref: Reactome:REACT_32363 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Sus scrofa"
xref: Reactome:REACT_33091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Canis familiaris"
xref: Reactome:REACT_77107 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Gallus gallus"
xref: Reactome:REACT_82876 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Xenopus tropicalis"
xref: Reactome:REACT_85383 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Mus musculus"
xref: Reactome:REACT_89091 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one, Xenopus tropicalis"
xref: Reactome:REACT_91545 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Danio rerio"
xref: Reactome:REACT_91980 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Taeniopygia guttata"
xref: Reactome:REACT_9949 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone), Homo sapiens"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000253
name: 3-keto sterol reductase activity
namespace: molecular_function
alt_id: GO:0050576
def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3-keto-steroid reductase activity" EXACT []
synonym: "3-KSR activity" EXACT [EC:1.1.1.270]
synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270]
xref: EC:1.1.1.270
xref: MetaCyc:1.1.1.270-RXN
xref: MetaCyc:RXN3O-4110
xref: MetaCyc:RXN66-19
xref: MetaCyc:RXN66-24
xref: MetaCyc:RXN66-314
xref: MetaCyc:RXN66-319
xref: Reactome:REACT_10036 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_10079 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Homo sapiens"
xref: Reactome:REACT_101014 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Schizosaccharomyces pombe"
xref: Reactome:REACT_102533 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_103243 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_103645 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_106908 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Saccharomyces cerevisiae"
xref: Reactome:REACT_107179 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_108259 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Canis familiaris"
xref: Reactome:REACT_31386 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_69122 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_78849 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_79755 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_82599 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_82943 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Sus scrofa"
xref: Reactome:REACT_84146 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Gallus gallus"
xref: Reactome:REACT_88684 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Bos taurus"
xref: Reactome:REACT_91551 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Mus musculus"
xref: Reactome:REACT_92714 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Rattus norvegicus"
xref: Reactome:REACT_95205 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Taeniopygia guttata"
xref: Reactome:REACT_96469 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_96959 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Danio rerio"
xref: Reactome:REACT_96973 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol), Xenopus tropicalis"
xref: Reactome:REACT_97126 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: RHEA:18412
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000254
name: C-4 methylsterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4-methylsterol oxidase activity" EXACT []
synonym: "methylsterol hydroxylase activity" RELATED []
synonym: "methylsterol monooxygenase activity" RELATED []
xref: EC:1.14.13.72
xref: MetaCyc:1.14.13.72-RXN
xref: Reactome:REACT_10059 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_10070 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Homo sapiens"
xref: Reactome:REACT_104089 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_104631 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_105610 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_105653 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_107576 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_112865 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_115505 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Xenopus tropicalis"
xref: Reactome:REACT_28712 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_29355 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_31445 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Mus musculus"
xref: Reactome:REACT_32207 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Sus scrofa"
xref: Reactome:REACT_32840 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_76969 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Oryza sativa"
xref: Reactome:REACT_79112 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_83222 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_84661 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Schizosaccharomyces pombe"
xref: Reactome:REACT_84707 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana"
xref: Reactome:REACT_85609 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Taeniopygia guttata"
xref: Reactome:REACT_86519 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_88988 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Canis familiaris"
xref: Reactome:REACT_89551 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Saccharomyces cerevisiae"
xref: Reactome:REACT_94158 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Gallus gallus"
xref: Reactome:REACT_95387 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Danio rerio"
xref: Reactome:REACT_95721 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Dictyostelium discoideum"
xref: Reactome:REACT_96643 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_97328 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Bos taurus"
xref: Reactome:REACT_99679 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol, Rattus norvegicus"
xref: Reactome:REACT_99766 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol, Arabidopsis thaliana"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0000255
name: allantoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0000256
name: allantoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin breakdown" EXACT []
synonym: "allantoin catabolism" EXACT []
synonym: "allantoin degradation" EXACT []
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0000257
name: nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd]
subset: gosubset_prok
synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1]
xref: EC:3.5.5.1
xref: MetaCyc:3.5.5.1-RXN
xref: RHEA:21727
xref: UM-BBD_enzymeID:e0283
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0000258
name: isoleucine/valine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005283
consider: GO:0005304
consider: GO:0015188

[Term]
id: GO:0000259
name: intracellular nucleoside transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai]
comment: This term was made obsolete because it contains component and function information.
is_obsolete: true
replaced_by: GO:0005337
replaced_by: GO:0005622

[Term]
id: GO:0000260
name: hydrogen-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0000261
name: sodium-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0046962

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
synonym: "mitochondrial DNA" NARROW []
synonym: "mitochondrial genome" RELATED []
synonym: "mtDNA" NARROW []
xref: NIF_Subcellular:sao1186327184
is_a: GO:0000229 ! cytoplasmic chromosome
is_a: GO:0044429 ! mitochondrial part
intersection_of: GO:0005694 ! chromosome
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0042645 ! mitochondrial nucleoid

[Term]
id: GO:0000263
name: heterotrimeric G-protein GTPase, alpha-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000264
name: heterotrimeric G-protein GTPase, beta-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000265
name: heterotrimeric G-protein GTPase, gamma-subunit
namespace: molecular_function
def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000266
name: mitochondrial fission
namespace: biological_process
def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
synonym: "mitochondrial division" EXACT []
synonym: "mitochondrial proliferation" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000267
name: cell fraction
namespace: cellular_component
def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000268
name: peroxisome targeting sequence binding
namespace: molecular_function
alt_id: GO:0005051
def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568]
synonym: "peroxisome targeting signal receptor" NARROW []
synonym: "PTS binding" EXACT []
synonym: "PTS receptor" NARROW []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0000269
name: toxin export channel activity
namespace: molecular_function
def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0015288 ! porin activity
is_a: GO:0019534 ! toxin transporter activity

[Term]
id: GO:0000270
name: peptidoglycan metabolic process
namespace: biological_process
alt_id: GO:0009284
def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732]
subset: gosubset_prok
synonym: "murein metabolic process" EXACT []
synonym: "murein metabolism" EXACT []
synonym: "peptidoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators]
subset: gosubset_prok
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0000274
name: mitochondrial proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0000275
name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000276
name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
intersection_of: part_of GO:0005739 ! mitochondrion
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000277
name: [cytochrome c]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59]
synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59]
xref: EC:2.1.1.59
xref: MetaCyc:2.1.1.59-RXN
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
subset: goslim_yeast
xref: Reactome:REACT_100451 "Cell Cycle, Mitotic, Taeniopygia guttata"
xref: Reactome:REACT_104035 "Cell Cycle, Mitotic, Sus scrofa"
xref: Reactome:REACT_104195 "Cell Cycle, Mitotic, Canis familiaris"
xref: Reactome:REACT_105856 "Cell Cycle, Mitotic, Danio rerio"
xref: Reactome:REACT_108233 "Cell Cycle, Mitotic, Saccharomyces cerevisiae"
xref: Reactome:REACT_152 "Cell Cycle, Mitotic, Homo sapiens"
xref: Reactome:REACT_28464 "Cell Cycle, Mitotic, Xenopus tropicalis"
xref: Reactome:REACT_28953 "Cell Cycle, Mitotic, Bos taurus"
xref: Reactome:REACT_33388 "Cell Cycle, Mitotic, Rattus norvegicus"
xref: Reactome:REACT_53493 "Cell Cycle, Mitotic, Plasmodium falciparum"
xref: Reactome:REACT_79085 "Cell Cycle, Mitotic, Schizosaccharomyces pombe"
xref: Reactome:REACT_84794 "Cell Cycle, Mitotic, Caenorhabditis elegans"
xref: Reactome:REACT_85137 "Cell Cycle, Mitotic, Gallus gallus"
xref: Reactome:REACT_85950 "Cell Cycle, Mitotic, Arabidopsis thaliana"
xref: Reactome:REACT_90332 "Cell Cycle, Mitotic, Mus musculus"
xref: Reactome:REACT_90846 "Cell Cycle, Mitotic, Oryza sativa"
xref: Reactome:REACT_96281 "Cell Cycle, Mitotic, Drosophila melanogaster"
xref: Reactome:REACT_97744 "Cell Cycle, Mitotic, Dictyostelium discoideum"
xref: Reactome:REACT_98208 "Cell Cycle, Mitotic, Mycobacterium tuberculosis"
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GOC:dph, GOC:mah, ISBN:0815316194]
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000281
name: cytokinesis after mitosis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: GO:0033205 ! cell cycle cytokinesis

[Term]
id: GO:0000282
name: cellular bud site selection
namespace: biological_process
def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010).
synonym: "bud site selection/establishment of cell polarity" BROAD []
is_a: GO:0007105 ! cytokinesis, site selection
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0033205 ! cell cycle cytokinesis

[Term]
id: GO:0000284
name: shmoo orientation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable.
is_obsolete: true
replaced_by: GO:0000753

[Term]
id: GO:0000285
name: 1-phosphatidylinositol-3-phosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13612]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT []
synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150]
xref: EC:2.7.1.150
xref: KEGG:R05802
xref: MetaCyc:2.7.1.150-RXN
xref: RHEA:13612
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0000286
name: alanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1]
subset: gosubset_prok
synonym: "AlaDH" RELATED [EC:1.4.1.1]
synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1]
synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1]
synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
xref: EC:1.4.1.1
xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN
xref: RHEA:18408
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0000287
name: magnesium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
subset: gosubset_prok
synonym: "magnesium binding" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0000288
name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]
synonym: "deadenylation-dependent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-dependent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylylation-dependent" EXACT []
synonym: "mRNA degradation, deadenylation-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT []
xref: Reactome:REACT_102357 "Deadenylation-dependent mRNA decay, Xenopus tropicalis"
xref: Reactome:REACT_103296 "Deadenylation-dependent mRNA decay, Gallus gallus"
xref: Reactome:REACT_105200 "Deadenylation-dependent mRNA decay, Plasmodium falciparum"
xref: Reactome:REACT_110041 "Deadenylation-dependent mRNA decay, Caenorhabditis elegans"
xref: Reactome:REACT_20639 "Deadenylation-dependent mRNA decay, Homo sapiens"
xref: Reactome:REACT_49520 "Deadenylation-dependent mRNA decay, Rattus norvegicus"
xref: Reactome:REACT_79530 "Deadenylation-dependent mRNA decay, Saccharomyces cerevisiae"
xref: Reactome:REACT_82315 "Deadenylation-dependent mRNA decay, Sus scrofa"
xref: Reactome:REACT_83961 "Deadenylation-dependent mRNA decay, Schizosaccharomyces pombe"
xref: Reactome:REACT_89647 "Deadenylation-dependent mRNA decay, Drosophila melanogaster"
xref: Reactome:REACT_90397 "Deadenylation-dependent mRNA decay, Mus musculus"
xref: Reactome:REACT_93483 "Deadenylation-dependent mRNA decay, Taeniopygia guttata"
xref: Reactome:REACT_95045 "Deadenylation-dependent mRNA decay, Oryza sativa"
xref: Reactome:REACT_95337 "Deadenylation-dependent mRNA decay, Arabidopsis thaliana"
xref: Reactome:REACT_96238 "Deadenylation-dependent mRNA decay, Dictyostelium discoideum"
xref: Reactome:REACT_96993 "Deadenylation-dependent mRNA decay, Bos taurus"
xref: Reactome:REACT_97186 "Deadenylation-dependent mRNA decay, Canis familiaris"
xref: Reactome:REACT_99680 "Deadenylation-dependent mRNA decay, Danio rerio"
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000289
name: nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
synonym: "3' to 5' mRNA deadenylation" RELATED []
synonym: "mRNA deadenylation" RELATED []
synonym: "nuclear mRNA poly(A) tail shortening" RELATED []
xref: Reactome:REACT_102415 "Deadenylation of mRNA, Rattus norvegicus"
xref: Reactome:REACT_104397 "Deadenylation of mRNA, Danio rerio"
xref: Reactome:REACT_109691 "Deadenylation of mRNA, Bos taurus"
xref: Reactome:REACT_111968 "Deadenylation of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_20514 "Deadenylation of mRNA, Homo sapiens"
xref: Reactome:REACT_30693 "Deadenylation of mRNA, Xenopus tropicalis"
xref: Reactome:REACT_31579 "Deadenylation of mRNA, Canis familiaris"
xref: Reactome:REACT_78492 "Deadenylation of mRNA, Mus musculus"
xref: Reactome:REACT_83021 "Deadenylation of mRNA, Taeniopygia guttata"
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0031124 ! mRNA 3'-end processing
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000290
name: deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]
synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT []
synonym: "deadenylylation-dependent decapping" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000291
name: nuclear-transcribed mRNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]
synonym: "exonucleolytic degradation of mRNA" EXACT []
synonym: "mRNA breakdown, exonucleolytic" EXACT []
synonym: "mRNA degradation, exonucleolytic" EXACT []
synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000292
name: RNA fragment catabolic process
namespace: biological_process
alt_id: GO:0030452
def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah]
subset: gosubset_prok
synonym: "group I intron catabolic process" NARROW []
synonym: "RNA fragment breakdown" EXACT []
synonym: "RNA fragment catabolism" EXACT [GOC:mah]
synonym: "RNA fragment degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000293
name: ferric-chelate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7]
comment: Note that this function was formerly EC:1.6.99.13.
synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7]
synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7]
synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7]
xref: EC:1.16.1.7
xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN
xref: RHEA:15064
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0000294
name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc]
synonym: "endonucleolytic mRNA decay" EXACT []
synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "mRNA catabolic process, endonucleolytic" EXACT []
synonym: "mRNA catabolism, endonucleolytic" EXACT []
synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000295
name: adenine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870]
xref: Reactome:REACT_101864 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Bos taurus"
xref: Reactome:REACT_107442 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Rattus norvegicus"
xref: Reactome:REACT_113419 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Oryza sativa"
xref: Reactome:REACT_16948 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Homo sapiens"
xref: Reactome:REACT_28950 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Mus musculus"
xref: Reactome:REACT_30244 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Drosophila melanogaster"
xref: Reactome:REACT_33254 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Dictyostelium discoideum"
xref: Reactome:REACT_80715 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Taeniopygia guttata"
xref: Reactome:REACT_83323 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Gallus gallus"
xref: Reactome:REACT_85299 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Saccharomyces cerevisiae"
xref: Reactome:REACT_86138 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Canis familiaris"
xref: Reactome:REACT_86805 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Danio rerio"
xref: Reactome:REACT_89005 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Sus scrofa"
xref: Reactome:REACT_91614 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP, Xenopus tropicalis"
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
relationship: part_of GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0000296
name: spermine transport
namespace: biological_process
def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732]
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0000297
name: spermine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai]
is_a: GO:0015203 ! polyamine transmembrane transporter activity
relationship: part_of GO:0000296 ! spermine transport

[Term]
id: GO:0000298
name: endopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10]
synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10]
xref: EC:3.6.1.10
xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000299
name: integral to membrane of membrane fraction
namespace: cellular_component
def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000300
name: peripheral to membrane of membrane fraction
namespace: cellular_component
def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000301
name: retrograde transport, vesicle recycling within Golgi
namespace: biological_process
def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]
synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0000302
name: response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
subset: gosubset_prok
synonym: "response to active oxygen species" EXACT []
synonym: "response to AOS" EXACT []
synonym: "response to reactive oxidative species" EXACT []
synonym: "response to reactive oxygen intermediate" EXACT []
synonym: "response to ROI" EXACT []
synonym: "response to ROS" EXACT []
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0000303
name: response to superoxide
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0000305 ! response to oxygen radical

[Term]
id: GO:0000304
name: response to singlet oxygen
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000305
name: response to oxygen radical
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000306
name: extrinsic to vacuolar membrane
namespace: cellular_component
def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
subset: goslim_pir
synonym: "CDK holoenzyme" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000308
name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
intersection_of: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0000309
name: nicotinamide-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1]
subset: gosubset_prok
synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1]
synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1]
synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMNAT activity" NARROW [EC:2.7.7.1]
xref: EC:2.7.7.1
xref: MetaCyc:2.7.7.1-RXN
xref: Reactome:REACT_101807 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Sus scrofa"
xref: Reactome:REACT_102033 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Canis familiaris"
xref: Reactome:REACT_103802 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Mus musculus"
xref: Reactome:REACT_105839 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Xenopus tropicalis"
xref: Reactome:REACT_107769 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Canis familiaris"
xref: Reactome:REACT_107952 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Drosophila melanogaster"
xref: Reactome:REACT_108630 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Sus scrofa"
xref: Reactome:REACT_108997 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Sus scrofa"
xref: Reactome:REACT_11116 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Homo sapiens"
xref: Reactome:REACT_11196 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Homo sapiens"
xref: Reactome:REACT_112138 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Arabidopsis thaliana"
xref: Reactome:REACT_11237 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Homo sapiens"
xref: Reactome:REACT_112385 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Oryza sativa"
xref: Reactome:REACT_114383 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Dictyostelium discoideum"
xref: Reactome:REACT_114560 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Schizosaccharomyces pombe"
xref: Reactome:REACT_114828 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Saccharomyces cerevisiae"
xref: Reactome:REACT_115028 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Dictyostelium discoideum"
xref: Reactome:REACT_29972 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Caenorhabditis elegans"
xref: Reactome:REACT_30979 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Oryza sativa"
xref: Reactome:REACT_31171 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Arabidopsis thaliana"
xref: Reactome:REACT_31453 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Taeniopygia guttata"
xref: Reactome:REACT_70840 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Saccharomyces cerevisiae"
xref: Reactome:REACT_77837 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Oryza sativa"
xref: Reactome:REACT_78904 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Dictyostelium discoideum"
xref: Reactome:REACT_79519 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Rattus norvegicus"
xref: Reactome:REACT_79745 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Danio rerio"
xref: Reactome:REACT_79909 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Canis familiaris"
xref: Reactome:REACT_80724 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Schizosaccharomyces pombe"
xref: Reactome:REACT_80917 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Danio rerio"
xref: Reactome:REACT_81520 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Taeniopygia guttata"
xref: Reactome:REACT_81532 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Bos taurus"
xref: Reactome:REACT_83285 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Mus musculus"
xref: Reactome:REACT_84119 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Mus musculus"
xref: Reactome:REACT_86854 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Xenopus tropicalis"
xref: Reactome:REACT_90006 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Saccharomyces cerevisiae"
xref: Reactome:REACT_92077 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Gallus gallus"
xref: Reactome:REACT_93517 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Drosophila melanogaster"
xref: Reactome:REACT_95186 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Rattus norvegicus"
xref: Reactome:REACT_96395 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Schizosaccharomyces pombe"
xref: Reactome:REACT_96707 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Gallus gallus"
xref: Reactome:REACT_97201 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1], Rattus norvegicus"
xref: Reactome:REACT_97323 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Taeniopygia guttata"
xref: Reactome:REACT_97434 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3], Arabidopsis thaliana"
xref: Reactome:REACT_98853 "Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2], Bos taurus"
xref: RHEA:21363
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0000310
name: xanthine phosphoribosyltransferase activity
namespace: molecular_function
alt_id: GO:0009043
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt]
subset: gosubset_prok
synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT []
synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
xref: EC:2.4.2.22
xref: MetaCyc:XANPRIBOSYLTRAN-RXN
xref: RHEA:10803
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000311
name: plastid large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044435 ! plastid part
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0009547 ! plastid ribosome
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000312
name: plastid small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044435 ! plastid part
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0009547 ! plastid ribosome
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome
is_a: GO:0044422 ! organelle part
intersection_of: GO:0005840 ! ribosome
intersection_of: part_of GO:0043226 ! organelle

[Term]
id: GO:0000314
name: organellar small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc]
is_a: GO:0015935 ! small ribosomal subunit
intersection_of: GO:0015935 ! small ribosomal subunit
intersection_of: part_of GO:0000313 ! organellar ribosome
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000315
name: organellar large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0015934 ! large ribosomal subunit
intersection_of: GO:0015934 ! large ribosomal subunit
intersection_of: part_of GO:0000313 ! organellar ribosome
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000316
name: sulfite transport
namespace: biological_process
def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc]
synonym: "sulphite transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0000318
name: protein-methionine-R-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995]
subset: gosubset_prok
xref: EC:1.8.4.-
is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0000319
name: sulfite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as]
synonym: "sulphite transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity
relationship: part_of GO:0000316 ! sulfite transport

[Term]
id: GO:0000320
name: re-entry into mitotic cell cycle
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000321
name: re-entry into mitotic cell cycle after pheromone arrest
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449]
is_a: GO:0000320 ! re-entry into mitotic cell cycle
is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000322
name: storage vacuole
namespace: cellular_component
def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000324
name: fungal-type vacuole
namespace: cellular_component
def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649]
synonym: "vacuole, cell cycle-correlated morphology" EXACT []
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0000325
name: plant-type vacuole
namespace: cellular_component
def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208]
synonym: "vacuole, cell cycle-independent morphology" EXACT []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000326
name: protein storage vacuole
namespace: cellular_component
def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000327
name: lytic vacuole within protein storage vacuole
namespace: cellular_component
def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490]
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0044437 ! vacuolar part
intersection_of: GO:0000323 ! lytic vacuole
intersection_of: part_of GO:0000326 ! protein storage vacuole
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0000328
name: fungal-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000329
name: fungal-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "fungal-type vacuolar membrane" RELATED []
synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000330
name: plant-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000331
name: contractile vacuole
namespace: cellular_component
def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, PMID:10503189]
xref: Wikipedia:Contractile_vacuole
is_a: GO:0005773 ! vacuole
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0000332
name: template for synthesis of G-rich strand of telomere DNA activity
namespace: molecular_function
def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242]
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
synonym: "telomerase RNA" EXACT []
synonym: "telomerase, template" EXACT []
is_a: GO:0000497 ! base pairing with DNA
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0000333
name: telomerase catalytic core complex
namespace: cellular_component
def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619]
is_a: GO:0005697 ! telomerase holoenzyme complex

[Term]
id: GO:0000334
name: 3-hydroxyanthranilate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17956]
subset: gosubset_prok
synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3HAO" RELATED [EC:1.13.11.6]
xref: EC:1.13.11.6
xref: KEGG:R02665
xref: MetaCyc:1.13.11.6-RXN
xref: Reactome:REACT_106067 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Danio rerio"
xref: Reactome:REACT_107237 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Rattus norvegicus"
xref: Reactome:REACT_108663 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Taeniopygia guttata"
xref: Reactome:REACT_108942 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Canis familiaris"
xref: Reactome:REACT_612 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Homo sapiens"
xref: Reactome:REACT_78765 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Caenorhabditis elegans"
xref: Reactome:REACT_81621 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Sus scrofa"
xref: Reactome:REACT_83535 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Saccharomyces cerevisiae"
xref: Reactome:REACT_83862 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Dictyostelium discoideum"
xref: Reactome:REACT_84121 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Gallus gallus"
xref: Reactome:REACT_86308 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Xenopus tropicalis"
xref: Reactome:REACT_93632 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Bos taurus"
xref: Reactome:REACT_94190 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde, Mus musculus"
xref: RHEA:17956
xref: UM-BBD_reactionID:r1027
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0000335
name: negative regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of DNA transposition" EXACT []
synonym: "down-regulation of DNA transposition" EXACT []
synonym: "downregulation of DNA transposition" EXACT []
synonym: "inhibition of DNA transposition" NARROW []
synonym: "negative regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010529 ! negative regulation of transposition
is_a: GO:0045910 ! negative regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006313 ! transposition, DNA-mediated
relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000336
name: positive regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "activation of DNA transposition" NARROW []
synonym: "positive regulation of DNA transposition" EXACT [GOC:dph]
synonym: "stimulation of DNA transposition" NARROW []
synonym: "up regulation of DNA transposition" EXACT []
synonym: "up-regulation of DNA transposition" EXACT []
synonym: "upregulation of DNA transposition" EXACT []
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010530 ! positive regulation of transposition
is_a: GO:0045911 ! positive regulation of DNA recombination
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006313 ! transposition, DNA-mediated
relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000337
name: regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0010528 ! regulation of transposition
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006313 ! transposition, DNA-mediated
relationship: regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000338
name: protein deneddylation
namespace: biological_process
def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0000339
name: RNA cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc]
synonym: "binding to mRNA cap" NARROW []
synonym: "mRNA cap binding" NARROW []
synonym: "snRNA cap binding" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000340
name: RNA 7-methylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
synonym: "RNA m7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000341
name: RNA trimethylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc]
synonym: "RNA m2,2,7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000342
name: RNA cap 4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975]
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000343
name: plastid-encoded plastid RNA polymerase complex A
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105]
synonym: "PEP-A" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000344
name: plastid-encoded plastid RNA polymerase complex B
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105]
synonym: "PEP-B" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000345
name: cytosolic DNA-directed RNA polymerase complex
namespace: cellular_component
def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566]
subset: gosubset_prok
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
subset: goslim_pir
synonym: "TREX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000348
name: nuclear mRNA branch site recognition
namespace: biological_process
alt_id: GO:0000370
alt_id: GO:0000371
def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian).
synonym: "spliceosomal A complex biosynthesis" NARROW []
synonym: "spliceosomal A complex formation" NARROW []
synonym: "spliceosomal B complex biosynthesis" NARROW []
synonym: "spliceosomal B complex formation" NARROW []
synonym: "U12-type nuclear mRNA branch site recognition" NARROW []
synonym: "U2-type nuclear mRNA branch site recognition" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly

[Term]
id: GO:0000349
name: generation of catalytic spliceosome for first transesterification step
namespace: biological_process
alt_id: GO:0000356
alt_id: GO:0000357
def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian).
synonym: "catalytic spliceosome assembly for first transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for first transesterification step" EXACT []
synonym: "spliceosomal A2-2 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-2 complex formation" NARROW []
synonym: "spliceosomal C1 complex biosynthesis" NARROW []
synonym: "spliceosomal C1 complex formation" NARROW []
synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW []
synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000350
name: generation of catalytic spliceosome for second transesterification step
namespace: biological_process
alt_id: GO:0000358
alt_id: GO:0000359
def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian).
synonym: "catalytic spliceosome assembly for second transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for second transesterification step" EXACT []
synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW []
synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW []
synonym: "formation of spliceosomal A2-2 complex" NARROW []
synonym: "formation of spliceosomal C1 complex" NARROW []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
synonym: "spliceosomal A2-3 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-3 complex formation" NARROW []
synonym: "spliceosomal C2 complex biosynthesis" NARROW []
synonym: "spliceosomal C2 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000352
name: trans assembly of SL-containing precatalytic spliceosome
namespace: biological_process
def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition

[Term]
id: GO:0000353
name: formation of quadruple SL/U4/U5/U6 snRNP
namespace: biological_process
def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897]
comment: Note that this step is analogous to 5' splice site selection in cis-splicing.
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition

[Term]
id: GO:0000354
name: cis assembly of pre-catalytic spliceosome
namespace: biological_process
alt_id: GO:0000360
alt_id: GO:0000361
def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals).
synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW []
synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW []
synonym: "formation of spliceosomal A2-1 complex" NARROW []
synonym: "formation of spliceosomal B1 complex" NARROW []
synonym: "spliceosomal A2-1 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-1 complex formation" NARROW []
synonym: "spliceosomal B1 complex biosynthesis" NARROW []
synonym: "spliceosomal B1 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosomal complex assembly
relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome

[Term]
id: GO:0000362
name: first U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000363
name: first U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000364
name: second U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000365
name: nuclear mRNA trans splicing, via spliceosome
namespace: biological_process
def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897]
synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW []
is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000366
name: intergenic nuclear mRNA trans splicing
namespace: biological_process
def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900]
is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome
is_a: GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000367
name: second U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000372
name: Group I intron splicing
namespace: biological_process
def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794]
comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone).
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile

[Term]
id: GO:0000373
name: Group II intron splicing
namespace: biological_process
def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794]
comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria.
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000374
name: Group III intron splicing
namespace: biological_process
def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794]
comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists.
subset: gosubset_prok
synonym: "mRNA splicing" RELATED []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000375
name: RNA splicing, via transesterification reactions
namespace: biological_process
alt_id: GO:0000385
alt_id: GO:0031202
def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc]
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
subset: gosubset_prok
synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah]
synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah]
synonym: "spliceosomal catalysis" RELATED []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000376
name: RNA splicing, via transesterification reactions with guanosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794]
subset: gosubset_prok
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000377
name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794]
subset: gosubset_prok
synonym: "lariat RNA biosynthesis" RELATED []
synonym: "lariat RNA formation" RELATED []
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000378
name: RNA exon ligation
namespace: biological_process
def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897]
comment: Note that this is not a part of spliceosomal RNA splicing.
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000379
name: tRNA-type intron splice site recognition and cleavage
namespace: biological_process
def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: gosubset_prok
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000380
name: alternative nuclear mRNA splicing, via spliceosome
namespace: biological_process
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
synonym: "splice site selection" BROAD []
is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000381
name: regulation of alternative nuclear mRNA splicing, via spliceosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
synonym: "splice site selection" BROAD []
is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome
relationship: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000384
name: first spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897]
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000386
name: second spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
is_a: GO:0003824 ! catalytic activity
relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000387
name: spliceosomal snRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah]
xref: Reactome:REACT_10002 "snRNA Cap hypermethylation, Homo sapiens"
xref: Reactome:REACT_10041 "Loading and methylation of Sm proteins onto SMN Complexes, Homo sapiens"
xref: Reactome:REACT_100869 "snRNP:Snurportin complex formation, Canis familiaris"
xref: Reactome:REACT_100915 "snRNP:Snurportin complex formation, Rattus norvegicus"
xref: Reactome:REACT_101141 "snRNP Assembly, Mus musculus"
xref: Reactome:REACT_102135 "snRNA Cap hypermethylation, Danio rerio"
xref: Reactome:REACT_102362 "snRNP complex assembly, Danio rerio"
xref: Reactome:REACT_107811 "snRNP Assembly, Gallus gallus"
xref: Reactome:REACT_108169 "snRNA Cap hypermethylation, Rattus norvegicus"
xref: Reactome:REACT_108689 "snRNP Assembly, Rattus norvegicus"
xref: Reactome:REACT_109502 "Loading and methylation of Sm proteins onto SMN Complexes, Danio rerio"
xref: Reactome:REACT_11066 "snRNP Assembly, Homo sapiens"
xref: Reactome:REACT_112455 "Loading and methylation of Sm proteins onto SMN Complexes, Xenopus tropicalis"
xref: Reactome:REACT_29060 "snRNP:Snurportin complex formation, Drosophila melanogaster"
xref: Reactome:REACT_29381 "snRNA Cap hypermethylation, Gallus gallus"
xref: Reactome:REACT_29703 "snRNP Assembly, Taeniopygia guttata"
xref: Reactome:REACT_29866 "snRNP:Snurportin complex formation, Mus musculus"
xref: Reactome:REACT_30125 "snRNP complex assembly, Bos taurus"
xref: Reactome:REACT_30397 "snRNP Assembly, Sus scrofa"
xref: Reactome:REACT_30799 "snRNP:Snurportin complex formation, Danio rerio"
xref: Reactome:REACT_30895 "snRNP complex assembly, Canis familiaris"
xref: Reactome:REACT_31007 "snRNP complex assembly, Mus musculus"
xref: Reactome:REACT_31363 "snRNP complex assembly, Gallus gallus"
xref: Reactome:REACT_31615 "snRNP Assembly, Drosophila melanogaster"
xref: Reactome:REACT_32359 "snRNP complex assembly, Rattus norvegicus"
xref: Reactome:REACT_54083 "snRNA Cap hypermethylation, Bos taurus"
xref: Reactome:REACT_77054 "snRNP Assembly, Canis familiaris"
xref: Reactome:REACT_79845 "snRNA Cap hypermethylation, Xenopus tropicalis"
xref: Reactome:REACT_81235 "Loading and methylation of Sm proteins onto SMN Complexes, Mus musculus"
xref: Reactome:REACT_81911 "snRNP complex assembly, Xenopus tropicalis"
xref: Reactome:REACT_82745 "snRNA Cap hypermethylation, Drosophila melanogaster"
xref: Reactome:REACT_85882 "snRNP Assembly, Danio rerio"
xref: Reactome:REACT_86133 "snRNP complex assembly, Drosophila melanogaster"
xref: Reactome:REACT_88437 "snRNP Assembly, Xenopus tropicalis"
xref: Reactome:REACT_88858 "snRNA Cap hypermethylation, Canis familiaris"
xref: Reactome:REACT_93259 "snRNP:Snurportin complex formation, Xenopus tropicalis"
xref: Reactome:REACT_93444 "snRNP Assembly, Bos taurus"
xref: Reactome:REACT_93869 "snRNP:Snurportin complex formation, Gallus gallus"
xref: Reactome:REACT_95210 "snRNA Cap hypermethylation, Mus musculus"
xref: Reactome:REACT_99021 "snRNP:Snurportin complex formation, Bos taurus"
xref: Reactome:REACT_9946 "snRNP:Snurportin complex formation, Homo sapiens"
xref: Reactome:REACT_9957 "snRNP complex assembly, Homo sapiens"
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000388
name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
namespace: biological_process
alt_id: GO:0000396
alt_id: GO:0000397
def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "spliceosomal A1 complex biosynthesis" NARROW []
synonym: "spliceosomal A1 complex formation" NARROW []
synonym: "spliceosomal B2 complex biosynthesis" NARROW []
synonym: "spliceosomal B2 complex formation" NARROW []
synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW []
synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000389
name: nuclear mRNA 3'-splice site recognition
namespace: biological_process
alt_id: GO:0000382
alt_id: GO:0000383
def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection

[Term]
id: GO:0000390
name: spliceosomal complex disassembly
namespace: biological_process
alt_id: GO:0000391
alt_id: GO:0000392
def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "spliceosome complex disassembly" EXACT []
synonym: "spliceosome disassembly" BROAD []
synonym: "U12-type spliceosome disassembly" NARROW []
synonym: "U2-type spliceosome disassembly" NARROW []
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000393
name: spliceosomal conformational changes to generate catalytic conformation
namespace: biological_process
def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000394
name: RNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897]
comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "mRNA splicing" BROAD []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000395
name: nuclear mRNA 5'-splice site recognition
namespace: biological_process
alt_id: GO:0000368
alt_id: GO:0000369
def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian).
synonym: "nuclear mRNA 5' splice site recognition" EXACT []
synonym: "spliceosomal CC complex biosynthesis" NARROW []
synonym: "spliceosomal CC complex formation" NARROW []
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection
relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome

[Term]
id: GO:0000398
name: nuclear mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0006374
alt_id: GO:0006375
def: "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897]
comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
synonym: "mRNA splicing" BROAD []
synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "pre-mRNA splicing" BROAD []
synonym: "splicing AT-AC intron" RELATED []
synonym: "splicing GT-AG intron" RELATED []
xref: Reactome:REACT_101135 "mRNA Splicing - Minor Pathway, Drosophila melanogaster"
xref: Reactome:REACT_101749 "mRNA Splicing - Minor Pathway, Caenorhabditis elegans"
xref: Reactome:REACT_106268 "mRNA Splicing - Major Pathway, Gallus gallus"
xref: Reactome:REACT_107907 "mRNA Splicing - Minor Pathway, Schizosaccharomyces pombe"
xref: Reactome:REACT_109091 "mRNA Splicing - Minor Pathway, Rattus norvegicus"
xref: Reactome:REACT_112200 "mRNA Splicing - Major Pathway, Arabidopsis thaliana"
xref: Reactome:REACT_114266 "mRNA Splicing - Major Pathway, Oryza sativa"
xref: Reactome:REACT_114738 "mRNA Splicing - Major Pathway, Taeniopygia guttata"
xref: Reactome:REACT_1753 "mRNA Splicing - Minor Pathway, Homo sapiens"
xref: Reactome:REACT_30984 "mRNA Splicing - Minor Pathway, Plasmodium falciparum"
xref: Reactome:REACT_32449 "mRNA Splicing - Minor Pathway, Canis familiaris"
xref: Reactome:REACT_34020 "mRNA Splicing - Minor Pathway, Dictyostelium discoideum"
xref: Reactome:REACT_467 "mRNA Splicing - Major Pathway, Homo sapiens"
xref: Reactome:REACT_81417 "mRNA Splicing - Major Pathway, Canis familiaris"
xref: Reactome:REACT_82149 "mRNA Splicing - Minor Pathway, Danio rerio"
xref: Reactome:REACT_85452 "mRNA Splicing - Major Pathway, Bos taurus"
xref: Reactome:REACT_86489 "mRNA Splicing - Minor Pathway, Mus musculus"
xref: Reactome:REACT_88186 "mRNA Splicing - Minor Pathway, Oryza sativa"
xref: Reactome:REACT_89168 "mRNA Splicing - Minor Pathway, Gallus gallus"
xref: Reactome:REACT_90296 "mRNA Splicing - Major Pathway, Danio rerio"
xref: Reactome:REACT_91088 "mRNA Splicing - Minor Pathway, Arabidopsis thaliana"
xref: Reactome:REACT_91611 "mRNA Splicing - Major Pathway, Drosophila melanogaster"
xref: Reactome:REACT_91773 "mRNA Splicing - Minor Pathway, Bos taurus"
xref: Reactome:REACT_93740 "mRNA Splicing - Major Pathway, Caenorhabditis elegans"
xref: Reactome:REACT_93843 "mRNA Splicing - Major Pathway, Rattus norvegicus"
xref: Reactome:REACT_95764 "mRNA Splicing - Major Pathway, Mus musculus"
xref: Reactome:REACT_99123 "mRNA Splicing - Major Pathway, Xenopus tropicalis"
xref: Reactome:REACT_99763 "mRNA Splicing - Minor Pathway, Xenopus tropicalis"
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0000399
name: cellular bud neck septin structure
namespace: cellular_component
def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc]
is_a: GO:0032155 ! cell division site part
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000400
name: four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "forked DNA binding" BROAD []
synonym: "Holliday junction binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000401
name: open form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "open form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000402
name: crossed form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "crossed form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000403
name: Y-form DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730]
synonym: "forked DNA binding" BROAD []
synonym: "splayed Y-form DNA binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000404
name: loop DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0000405
name: bubble DNA binding
namespace: molecular_function
def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000406
name: double-strand/single-strand DNA junction binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000407
name: pre-autophagosomal structure
namespace: cellular_component
def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
synonym: "isolation membrane" RELATED []
synonym: "PAS" EXACT []
synonym: "perivacuolar space" NARROW []
synonym: "phagophore" RELATED [GOC:bf]
synonym: "phagophore assembly site" RELATED []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000408
name: EKC/KEOPS complex
namespace: cellular_component
def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308]
synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT []
synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000409
name: regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0000410
name: negative regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah]
synonym: "down regulation of transcription by galactose" EXACT []
synonym: "down-regulation of transcription by galactose" EXACT []
synonym: "downregulation of transcription by galactose" EXACT []
synonym: "inhibition of transcription by galactose" NARROW []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000411
name: positive regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription by galactose" NARROW []
synonym: "stimulation of transcription by galactose" NARROW []
synonym: "up regulation of transcription by galactose" EXACT []
synonym: "up-regulation of transcription by galactose" EXACT []
synonym: "upregulation of transcription by galactose" EXACT []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045991 ! carbon catabolite activation of transcription

[Term]
id: GO:0000412
name: histone peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc]
synonym: "histone proline isomerization" EXACT []
is_a: GO:0000413 ! protein peptidyl-prolyl isomerization
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0000413
name: protein peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
synonym: "protein proline isomerization" EXACT []
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0000414
name: regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
is_a: GO:0031060 ! regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0010452 ! histone H3-K36 methylation
relationship: regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000415
name: negative regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "down regulation of histone H3-K36 methylation" EXACT []
synonym: "down-regulation of histone H3-K36 methylation" EXACT []
synonym: "downregulation of histone H3-K36 methylation" EXACT []
synonym: "inhibition of histone H3-K36 methylation" NARROW []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031061 ! negative regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010452 ! histone H3-K36 methylation
relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000416
name: positive regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "activation of histone H3-K36 methylation" NARROW []
synonym: "stimulation of histone H3-K36 methylation" NARROW []
synonym: "up regulation of histone H3-K36 methylation" EXACT []
synonym: "up-regulation of histone H3-K36 methylation" EXACT []
synonym: "upregulation of histone H3-K36 methylation" EXACT []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031062 ! positive regulation of histone methylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010452 ! histone H3-K36 methylation
relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000417
name: HIR complex
namespace: cellular_component
def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700]
synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105]
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0000418
name: DNA-directed RNA polymerase IV complex
namespace: cellular_component
alt_id: GO:0000420
def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IVa complex" EXACT []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000419
name: DNA-directed RNA polymerase V complex
namespace: cellular_component
alt_id: GO:0080137
def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459]
synonym: "DNA-directed RNA polymerase IVb complex" EXACT []
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000421
name: autophagic vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete]
synonym: "autophagosome membrane" EXACT []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005776 ! autophagic vacuole

[Term]
id: GO:0000422
name: mitochondrion degradation
namespace: biological_process
def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [PMID:15798367]
synonym: "mitophagy" EXACT []
xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy
xref: Wikipedia:Mitophagy
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0000423
name: macromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367]
is_a: GO:0000422 ! mitochondrion degradation
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0000424
name: micromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367]
is_a: GO:0000422 ! mitochondrion degradation
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0000425
name: macropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210]
is_a: GO:0016236 ! macroautophagy
is_a: GO:0030242 ! peroxisome degradation

[Term]
id: GO:0000426
name: micropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210]
is_a: GO:0016237 ! microautophagy
is_a: GO:0030242 ! peroxisome degradation

[Term]
id: GO:0000427
name: plastid-encoded plastid RNA polymerase complex
namespace: cellular_component
def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044435 ! plastid part
intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex
intersection_of: part_of GO:0009536 ! plastid

[Term]
id: GO:0000428
name: DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0000429
name: carbon catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045990 ! carbon catabolite regulation of transcription

[Term]
id: GO:0000430
name: regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0000431
name: regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000432
name: positive regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter
is_a: GO:0046016 ! positive regulation of transcription by glucose

[Term]
id: GO:0000433
name: negative regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter
is_a: GO:0045014 ! negative regulation of transcription by glucose

[Term]
id: GO:0000434
name: negative regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW []
is_a: GO:0000410 ! negative regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter

[Term]
id: GO:0000435
name: positive regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
is_a: GO:0000411 ! positive regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000436
name: carbon catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0045991 ! carbon catabolite activation of transcription

[Term]
id: GO:0000437
name: carbon catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc]
synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0045013 ! carbon catabolite repression of transcription

[Term]
id: GO:0000438
name: core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000439 ! core TFIIH complex
is_a: GO:0044451 ! nucleoplasm part
intersection_of: GO:0000439 ! core TFIIH complex
intersection_of: part_of GO:0005675 ! holo TFIIH complex
relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex

[Term]
id: GO:0000439
name: core TFIIH complex
namespace: cellular_component
def: "The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
relationship: part_of GO:0000441 ! SSL2-core TFIIH complex

[Term]
id: GO:0000440
name: core TFIIH complex portion of NEF3 complex
namespace: cellular_component
def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000439 ! core TFIIH complex
intersection_of: GO:0000439 ! core TFIIH complex
intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex
relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex

[Term]
id: GO:0000441
name: SSL2-core TFIIH complex
namespace: cellular_component
def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0000442
name: SSL2-core TFIIH complex portion of NEF3 complex
namespace: cellular_component
def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000441 ! SSL2-core TFIIH complex
is_a: GO:0044428 ! nuclear part
intersection_of: GO:0000441 ! SSL2-core TFIIH complex
intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex
relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex

[Term]
id: GO:0000443
name: SSL2-core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000441 ! SSL2-core TFIIH complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0005675 ! holo TFIIH complex

[Term]
id: GO:0000444
name: MIS12/MIND type complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]
synonym: "Mis12 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000445
name: THO complex part of transcription export complex
namespace: cellular_component
def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
synonym: "THO complex part of TREX complex" EXACT []
is_a: GO:0000347 ! THO complex
intersection_of: GO:0000347 ! THO complex
intersection_of: part_of GO:0000346 ! transcription export complex
relationship: part_of GO:0000346 ! transcription export complex

[Term]
id: GO:0000446
name: nucleoplasmic THO complex
namespace: cellular_component
def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
is_a: GO:0000347 ! THO complex
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0000447
name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A2" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000448
name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:0000490
def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "cleavage at C2" RELATED []
synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000449
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000450
name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000451
name: rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0000452
name: snoRNA guided rRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337]
synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000453
name: enzyme-directed rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000454
name: snoRNA guided rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000455
name: enzyme-directed rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000456
name: dimethylation involved in SSU-rRNA maturation
namespace: biological_process
def: "Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337]
is_a: GO:0031167 ! rRNA methylation
relationship: part_of GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000457
name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000458
name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000459
name: exonucleolytic trimming involved in rRNA processing
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators]
synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000469 ! cleavage involved in rRNA processing

[Term]
id: GO:0000460
name: maturation of 5.8S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000461
name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at site D" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000462
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000463
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000464
name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at A3" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000465
name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000466
name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000467
name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000468
name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
synonym: "processing at B2" NARROW []
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000469
name: cleavage involved in rRNA processing
namespace: biological_process
def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators]
synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
intersection_of: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
intersection_of: part_of GO:0006364 ! rRNA processing
relationship: part_of GO:0006364 ! rRNA processing

[Term]
id: GO:0000470
name: maturation of LSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000471
name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410]
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000472
name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A1" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000473
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000474
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000475
name: maturation of 2S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000476
name: maturation of 4.5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000477
name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "processing at C1" NARROW []
is_a: GO:0000469 ! cleavage involved in rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000478
name: endonucleolytic cleavage involved in rRNA processing
namespace: biological_process
def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000469 ! cleavage involved in rRNA processing

[Term]
id: GO:0000479
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000480
name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326]
synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326]
synonym: "endonucleolytic cleavage at A0" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000481
name: maturation of 5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000482
name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000481 ! maturation of 5S rRNA

[Term]
id: GO:0000483
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0000484
name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000485
name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA

[Term]
id: GO:0000486
name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000487
name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000488
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000489
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000491
name: small nucleolar ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "snoRNP assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly

[Term]
id: GO:0000492
name: box C/D snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000493
name: box H/ACA snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000494
name: box C/D snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc]
synonym: "box C/D snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034963 ! box C/D snoRNA processing

[Term]
id: GO:0000495
name: box H/ACA snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc]
synonym: "box H/ACA snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034964 ! box H/ACA snoRNA processing

[Term]
id: GO:0000496
name: base pairing
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
xref: Wikipedia:Base_pair
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0000497
name: base pairing with DNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0000498
name: base pairing with RNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000499
name: base pairing with mRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000500
name: RNA polymerase I upstream activating factor complex
namespace: cellular_component
def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378]
synonym: "RNA polymerase I upstream activation factor complex" EXACT []
synonym: "UAF" EXACT []
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0000501
name: flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae." [DOI:10.1016/S0963-9969(99)00021-6, GOC:sgd_curators]
subset: gosubset_prok
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0000502
name: proteasome complex
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb]
subset: goslim_pir
synonym: "26S proteasome" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000504
name: proteasome regulatory particle (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
synonym: "26S proteasome" NARROW []
is_obsolete: true

[Term]
id: GO:0000506
name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
synonym: "GPI-GlcNAc transferase complex" EXACT []
synonym: "GPI-GnT complex" EXACT []
synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0000578
name: embryonic axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification

[Term]
id: GO:0000700
name: mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000701
name: purine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "A/G-specific adenine DNA glycosylase activity" NARROW []
xref: EC:3.2.2.-
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0000702
name: oxidized base lesion DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
subset: gosubset_prok
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000703
name: oxidized pyrimidine base lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0019004
def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
subset: gosubset_prok
synonym: "bifunctional DNA glycosylase" BROAD []
synonym: "DNA glycosylase/AP-lyase" BROAD []
synonym: "DNA glycosylase/beta-lyase" BROAD []
synonym: "endodeoxyribonuclease III" RELATED []
synonym: "endonuclease III" RELATED []
synonym: "endonuclease VIII activity" RELATED []
synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: Reactome:REACT_101001 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_101090 "Cleavage of dihydrouracil by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_101315 "Cleavage of cytosine glycol by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_101744 "Cleavage of thymine glycol by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_102306 "Cleavage of cytosine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_103688 "Cleavage of thymine glycol by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_103837 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_104179 "Cleavage of cytosine glycol by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_104266 "Cleavage of thymine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_104313 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_105538 "Cleavage of cytosine glycol by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_105622 "Cleavage of thymine glycol by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_105635 "Cleavage of cytosine glycol by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_105967 "Cleavage of thymine glycol by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_106253 "Cleavage of thymine glycol by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_107207 "Cleavage of cytosine glycol by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_107703 "Cleavage of dihydrouracil by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_107763 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_108637 "Cleavage of cytosine glycol by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_108860 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_109023 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_109743 "Cleavage of cytosine glycol by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_2021 "Cleavage of cytosine glycol by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_2157 "Cleavage of dihydrouracil by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_2255 "Cleavage of thymine glycol by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_28127 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_28180 "Cleavage of thymine glycol by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_29323 "Cleavage of dihydrouracil by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_29518 "Cleavage of cytosine glycol by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_30621 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_30642 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_30750 "Cleavage of dihydrouracil by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_32240 "Cleavage of cytosine glycol by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_32421 "Cleavage of thymine glycol by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_32931 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_33078 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_33307 "Cleavage of cytosine glycol by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_33417 "Cleavage of cytosine glycol by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_33820 "Cleavage of thymine glycol by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_33839 "Cleavage of thymine glycol by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_33951 "Cleavage of dihydrouracil by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_34296 "Cleavage of dihydrouracil by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_77336 "Cleavage of cytosine glycol by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_77526 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_78108 "Cleavage of cytosine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_78298 "Cleavage of dihydrouracil by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_78343 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_78458 "Cleavage of dihydrouracil by hNTH1 glycosylase, Danio rerio"
xref: Reactome:REACT_78529 "Cleavage of dihydrouracil by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_79663 "Cleavage of dihydrouracil by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_79864 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Arabidopsis thaliana"
xref: Reactome:REACT_80155 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Schizosaccharomyces pombe"
xref: Reactome:REACT_81464 "Cleavage of dihydrouracil by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_81531 "Cleavage of thymine glycol by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_82850 "Cleavage of dihydrouracil by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_83701 "Cleavage of thymine glycol by hNTH1 glycosylase, Dictyostelium discoideum"
xref: Reactome:REACT_83784 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Gallus gallus"
xref: Reactome:REACT_84042 "Cleavage of dihydrouracil by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_84141 "Cleavage of cytosine glycol by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_84471 "Cleavage of dihydrouracil by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_85485 "Cleavage of dihydrouracil by hNTH1 glycosylase, Oryza sativa"
xref: Reactome:REACT_87055 "Cleavage of cytosine glycol by hNTH1 glycosylase, Saccharomyces cerevisiae"
xref: Reactome:REACT_87146 "Cleavage of cytosine glycol by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_87389 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_87494 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Mycobacterium tuberculosis"
xref: Reactome:REACT_87850 "Cleavage of thymine glycol by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_87925 "Cleavage of dihydrouracil by hNTH1 glycosylase, Caenorhabditis elegans"
xref: Reactome:REACT_890 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Homo sapiens"
xref: Reactome:REACT_89137 "Cleavage of dihydrouracil by hNTH1 glycosylase, Bos taurus"
xref: Reactome:REACT_89396 "Cleavage of cytosine glycol by hNTH1 glycosylase, Taeniopygia guttata"
xref: Reactome:REACT_90163 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_90552 "Cleavage of thymine glycol by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_92193 "Cleavage of dihydrouracil by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_92466 "Cleavage of cytosine glycol by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_93244 "Cleavage of thymine glycol by hNTH1 glycosylase, Sus scrofa"
xref: Reactome:REACT_93473 "Cleavage of dihydrouracil by hNTH1 glycosylase, Mus musculus"
xref: Reactome:REACT_94304 "Cleavage of thymine glycol by hNTH1 glycosylase, Staphylococcus aureus N315"
xref: Reactome:REACT_95145 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Rattus norvegicus"
xref: Reactome:REACT_96277 "Cleavage of thymine glycol by hNTH1 glycosylase, Escherichia coli"
xref: Reactome:REACT_96754 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Xenopus tropicalis"
xref: Reactome:REACT_97913 "Cleavage of thymine glycol by hNTH1 glycosylase, Drosophila melanogaster"
xref: Reactome:REACT_97922 "Cleavage of thymine glycol by hNTH1 glycosylase, Plasmodium falciparum"
xref: Reactome:REACT_98089 "Cleavage of formamidopyrimidine by hNTH1 glycosylase, Canis familiaris"
xref: Reactome:REACT_99032 "Cleavage of thymine glycol by hNTH1 glycosylase, Mycobacterium tuberculosis"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity

[Term]
id: GO:0000704
name: pyrimidine dimer DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000705
name: achiasmate meiosis I
namespace: biological_process
def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
is_a: GO:0007127 ! meiosis I

[Term]
id: GO:0000706
name: meiotic DNA double-strand break processing
namespace: biological_process
def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
is_a: GO:0000729 ! DNA double-strand break processing
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0000729 ! DNA double-strand break processing
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000707
name: meiotic DNA recombinase assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
is_a: GO:0000730 ! DNA recombinase assembly
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0000730 ! DNA recombinase assembly
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000708
name: meiotic strand invasion
namespace: biological_process
def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
synonym: "meiotic D-loop biosynthesis" RELATED []
synonym: "meiotic D-loop formation" RELATED []
synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0042148 ! strand invasion
intersection_of: GO:0042148 ! strand invasion
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000709
name: meiotic joint molecule formation
namespace: biological_process
def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000710
name: meiotic mismatch repair
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
is_a: GO:0006298 ! mismatch repair
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0006298 ! mismatch repair
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000711
name: meiotic DNA repair synthesis
namespace: biological_process
def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000712
name: resolution of meiotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
synonym: "crossover biosynthesis" NARROW []
synonym: "crossover formation" NARROW []
synonym: "formation of chiasmata" NARROW []
synonym: "homologous chromosome separation at meiosis I" EXACT []
synonym: "meiotic homologous chromosome separation" RELATED []
synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah]
is_a: GO:0051307 ! meiotic chromosome separation
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000713
name: meiotic heteroduplex formation
namespace: biological_process
def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0030491 ! heteroduplex formation
intersection_of: GO:0030491 ! heteroduplex formation
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0006310 ! DNA recombination
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000714
name: meiotic strand displacement
namespace: biological_process
def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0000732 ! strand displacement
is_a: GO:0022402 ! cell cycle process
intersection_of: GO:0000732 ! strand displacement
intersection_of: part_of GO:0051321 ! meiotic cell cycle
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000715
name: nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
xref: Reactome:REACT_107456 "DNA Damage Recognition in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_112311 "DNA Damage Recognition in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_115249 "DNA Damage Recognition in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_115544 "DNA damage recognition in global genomic repair, Gallus gallus"
xref: Reactome:REACT_29640 "DNA Damage Recognition in GG-NER, Dictyostelium discoideum"
xref: Reactome:REACT_30130 "DNA Damage Recognition in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_31764 "DNA Damage Recognition in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_476 "DNA Damage Recognition in GG-NER, Homo sapiens"
xref: Reactome:REACT_77558 "DNA Damage Recognition in GG-NER, Danio rerio"
xref: Reactome:REACT_81184 "DNA Damage Recognition in GG-NER, Bos taurus"
xref: Reactome:REACT_82635 "DNA Damage Recognition in GG-NER, Canis familiaris"
xref: Reactome:REACT_86796 "DNA Damage Recognition in GG-NER, Gallus gallus"
xref: Reactome:REACT_89770 "DNA Damage Recognition in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_92224 "DNA Damage Recognition in GG-NER, Mus musculus"
xref: Reactome:REACT_94418 "DNA Damage Recognition in GG-NER, Sus scrofa"
xref: Reactome:REACT_95988 "DNA Damage Recognition in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_97740 "DNA Damage Recognition in GG-NER, Oryza sativa"
xref: Reactome:REACT_98000 "DNA Damage Recognition in GG-NER, Schizosaccharomyces pombe"
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000716
name: transcription-coupled nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED []
xref: Reactome:REACT_100470 "RNA Pol II is blocked by the lesion leading to reduced transcription, Plasmodium falciparum"
xref: Reactome:REACT_100673 "RNA Pol II is blocked by the lesion leading to reduced transcription, Dictyostelium discoideum"
xref: Reactome:REACT_100817 "RNA Pol II is blocked by the lesion leading to reduced transcription, Mus musculus"
xref: Reactome:REACT_101583 "RNA Pol II is blocked by the lesion leading to reduced transcription, Drosophila melanogaster"
xref: Reactome:REACT_103224 "RNA Pol II is blocked by the lesion leading to reduced transcription, Saccharomyces cerevisiae"
xref: Reactome:REACT_104426 "RNA Pol II is blocked by the lesion leading to reduced transcription, Oryza sativa"
xref: Reactome:REACT_106854 "RNA Pol II is blocked by the lesion leading to reduced transcription, Schizosaccharomyces pombe"
xref: Reactome:REACT_1947 "RNA Pol II is blocked by the lesion leading to reduced transcription, Homo sapiens"
xref: Reactome:REACT_78581 "RNA Pol II is blocked by the lesion leading to reduced transcription, Gallus gallus"
xref: Reactome:REACT_78888 "RNA Pol II is blocked by the lesion leading to reduced transcription, Canis familiaris"
xref: Reactome:REACT_80099 "RNA Pol II is blocked by the lesion leading to reduced transcription, Xenopus tropicalis"
xref: Reactome:REACT_86060 "RNA Pol II is blocked by the lesion leading to reduced transcription, Bos taurus"
xref: Reactome:REACT_86572 "RNA Pol II is blocked by the lesion leading to reduced transcription, Taeniopygia guttata"
xref: Reactome:REACT_86848 "RNA Pol II is blocked by the lesion leading to reduced transcription, Caenorhabditis elegans"
xref: Reactome:REACT_88150 "RNA Pol II is blocked by the lesion leading to reduced transcription, Danio rerio"
xref: Reactome:REACT_90318 "RNA Pol II is blocked by the lesion leading to reduced transcription, Arabidopsis thaliana"
xref: Reactome:REACT_96982 "RNA Pol II is blocked by the lesion leading to reduced transcription, Rattus norvegicus"
is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition
relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0000717
name: nucleotide-excision repair, DNA duplex unwinding
namespace: biological_process
def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus"
xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa"
xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens"
xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata"
xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus"
xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio"
xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans"
xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis"
xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus"
xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster"
xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris"
xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus"
xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae"
xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana"
xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa"
is_a: GO:0032508 ! DNA duplex unwinding
intersection_of: GO:0032508 ! DNA duplex unwinding
intersection_of: part_of GO:0006289 ! nucleotide-excision repair
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000718
name: nucleotide-excision repair, DNA damage removal
namespace: biological_process
def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:REACT_102444 "Dual incision reaction in GG-NER, Oryza sativa"
xref: Reactome:REACT_104645 "Dual incision reaction in GG-NER, Taeniopygia guttata"
xref: Reactome:REACT_109019 "Dual incision reaction in GG-NER, Bos taurus"
xref: Reactome:REACT_30192 "Dual incision reaction in GG-NER, Xenopus tropicalis"
xref: Reactome:REACT_311 "Dual incision reaction in GG-NER, Homo sapiens"
xref: Reactome:REACT_31322 "Dual incision reaction in GG-NER, Saccharomyces cerevisiae"
xref: Reactome:REACT_32014 "Dual incision reaction in GG-NER, Danio rerio"
xref: Reactome:REACT_52725 "Dual incision reaction in GG-NER, Gallus gallus"
xref: Reactome:REACT_89200 "Dual incision reaction in GG-NER, Sus scrofa"
xref: Reactome:REACT_90961 "Dual incision reaction in GG-NER, Arabidopsis thaliana"
xref: Reactome:REACT_91383 "Dual incision reaction in GG-NER, Drosophila melanogaster"
xref: Reactome:REACT_92216 "Dual incision reaction in GG-NER, Canis familiaris"
xref: Reactome:REACT_92900 "Dual incision reaction in GG-NER, Rattus norvegicus"
xref: Reactome:REACT_93068 "Dual incision reaction in GG-NER, Schizosaccharomyces pombe"
xref: Reactome:REACT_96787 "Dual incision reaction in GG-NER, Caenorhabditis elegans"
xref: Reactome:REACT_99802 "Dual incision reaction in GG-NER, Mus musculus"
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0044349 ! DNA excision
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000719
name: photoreactive repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair by photolyase" NARROW []
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000720
name: pyrimidine dimer repair by nucleotide-excision repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh]
comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'.
subset: gosubset_prok
is_a: GO:0006289 ! nucleotide-excision repair
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000721
name: (R,R)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4]
subset: gosubset_prok
synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4]
xref: EC:1.1.1.4
xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN
xref: RHEA:24343
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000722
name: telomere maintenance via recombination
namespace: biological_process
def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]
synonym: "telomerase-independent telomere maintenance" RELATED []
xref: Reactome:REACT_101373 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_101439 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_101498 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_101756 "Polymerase switching on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_102170 "Polymerase switching on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_102248 "RPA binds to the Flap on the C-strand, Danio rerio"
xref: Reactome:REACT_102860 "Polymerase switching on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_102881 "Removal of the Flap Intermediate from the C-strand, Oryza sativa"
xref: Reactome:REACT_103207 "Telomere C-strand synthesis initiation, Dictyostelium discoideum"
xref: Reactome:REACT_103350 "Telomere C-strand synthesis initiation, Schizosaccharomyces pombe"
xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_103857 "Recruitment of Dna2 endonuclease to the C strand, Sus scrofa"
xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_104453 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_104638 "Polymerase switching on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_105258 "Formation of Processive Complex on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa"
xref: Reactome:REACT_105491 "Formation of Processive Complex on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_106206 "Removal of the Flap Intermediate from the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_106874 "Polymerase switching on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_106919 "Joining of adjacent Okazaki fragments of the C-strand, Oryza sativa"
xref: Reactome:REACT_106924 "Removal of remaining Flap from the C-strand, Bos taurus"
xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe"
xref: Reactome:REACT_107163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_107299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_107682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_108058 "Formation of Processive Complex on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_108285 "Processive synthesis on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_108876 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_109084 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus"
xref: Reactome:REACT_109676 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_110206 "Recruitment of Dna2 endonuclease to the C strand, Canis familiaris"
xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris"
xref: Reactome:REACT_110586 "Removal of remaining Flap from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_28301 "Removal of remaining Flap from the C-strand, Danio rerio"
xref: Reactome:REACT_28337 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_28438 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_28735 "Formation of the Flap Intermediate on the C-strand, Oryza sativa"
xref: Reactome:REACT_28845 "Removal of the Flap Intermediate from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio"
xref: Reactome:REACT_29091 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Danio rerio"
xref: Reactome:REACT_29268 "Polymerase switching on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_29498 "Joining of adjacent Okazaki fragments of the C-strand, Mus musculus"
xref: Reactome:REACT_29561 "Telomere C-strand synthesis initiation, Caenorhabditis elegans"
xref: Reactome:REACT_29730 "Processive synthesis on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_29736 "Removal of remaining Flap from the C-strand, Oryza sativa"
xref: Reactome:REACT_30132 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_30146 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_30357 "Recruitment of Dna2 endonuclease to the C strand, Oryza sativa"
xref: Reactome:REACT_30676 "Processive synthesis on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_31415 "Polymerase switching on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_31855 "Recruitment of Dna2 endonuclease to the C strand, Xenopus tropicalis"
xref: Reactome:REACT_31896 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Mus musculus"
xref: Reactome:REACT_32409 "Formation of Processive Complex on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_32656 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_32714 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_32801 "Recruitment of Dna2 endonuclease to the C strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_33015 "Formation of the Flap Intermediate on the C-strand, Sus scrofa"
xref: Reactome:REACT_33071 "Polymerase switching on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_33514 "Recruitment of Dna2 endonuclease to the C strand, Danio rerio"
xref: Reactome:REACT_33663 "Processive synthesis on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_33974 "Formation of the Flap Intermediate on the C-strand, Mus musculus"
xref: Reactome:REACT_34757 "Polymerase switching on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_57279 "Processive synthesis on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa"
xref: Reactome:REACT_77820 "Formation of Processive Complex on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_77906 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_78056 "Formation of the Flap Intermediate on the C-strand, Rattus norvegicus"
xref: Reactome:REACT_78182 "Telomere C-strand synthesis initiation, Rattus norvegicus"
xref: Reactome:REACT_78501 "Formation of the Flap Intermediate on the C-strand, Bos taurus"
xref: Reactome:REACT_78969 "Joining of adjacent Okazaki fragments of the C-strand, Bos taurus"
xref: Reactome:REACT_79008 "Recruitment of Dna2 endonuclease to the C strand, Arabidopsis thaliana"
xref: Reactome:REACT_79101 "Removal of the Flap Intermediate from the C-strand, Danio rerio"
xref: Reactome:REACT_7949 "RPA binds to the Flap on the C-strand, Homo sapiens"
xref: Reactome:REACT_7955 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Homo sapiens"
xref: Reactome:REACT_7967 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7973 "Formation of the Flap Intermediate on the C-strand, Homo sapiens"
xref: Reactome:REACT_7975 "Removal of remaining Flap from the C-strand, Homo sapiens"
xref: Reactome:REACT_7979 "Formation of Processive Complex on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7987 "Polymerase switching on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7993 "Telomere C-strand synthesis initiation, Homo sapiens"
xref: Reactome:REACT_7994 "Joining of adjacent Okazaki fragments of the C-strand, Homo sapiens"
xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_7999 "Removal of the Flap Intermediate from the C-strand, Homo sapiens"
xref: Reactome:REACT_8000 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8008 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8015 "Recruitment of Dna2 endonuclease to the C strand, Homo sapiens"
xref: Reactome:REACT_80165 "Removal of the Flap Intermediate from the C-strand, Taeniopygia guttata"
xref: Reactome:REACT_8027 "Processive synthesis on the C-strand of the telomere, Homo sapiens"
xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens"
xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_80567 "Polymerase switching on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_80653 "Telomere C-strand synthesis initiation, Sus scrofa"
xref: Reactome:REACT_80757 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_81201 "Removal of remaining Flap from the C-strand, Mus musculus"
xref: Reactome:REACT_81258 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_81387 "Formation of Processive Complex on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_81697 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa"
xref: Reactome:REACT_81990 "Joining of adjacent Okazaki fragments of the C-strand, Danio rerio"
xref: Reactome:REACT_82014 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_82097 "Processive synthesis on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_82465 "Processive synthesis on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_82605 "Telomere C-strand synthesis initiation, Canis familiaris"
xref: Reactome:REACT_82834 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_83118 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_83299 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_83482 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_83617 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_84276 "Recruitment of Dna2 endonuclease to the C strand, Taeniopygia guttata"
xref: Reactome:REACT_84292 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Bos taurus"
xref: Reactome:REACT_84527 "Joining of adjacent Okazaki fragments of the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus"
xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_85614 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_85781 "Joining of adjacent Okazaki fragments of the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_85910 "Joining of adjacent Okazaki fragments of the C-strand, Canis familiaris"
xref: Reactome:REACT_85945 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_86438 "Removal of the Flap Intermediate from the C-strand, Mus musculus"
xref: Reactome:REACT_86551 "Formation of the Flap Intermediate on the C-strand, Danio rerio"
xref: Reactome:REACT_86566 "RPA binds to the Flap on the C-strand, Mus musculus"
xref: Reactome:REACT_86673 "Processive synthesis on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_86894 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Bos taurus"
xref: Reactome:REACT_87128 "Processive synthesis on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_87148 "Recruitment of Dna2 endonuclease to the C strand, Rattus norvegicus"
xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_87564 "Recruitment of Dna2 endonuclease to the C strand, Mus musculus"
xref: Reactome:REACT_87776 "Removal of the Flap Intermediate from the C-strand, Canis familiaris"
xref: Reactome:REACT_87852 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand, Canis familiaris"
xref: Reactome:REACT_87982 "Removal of the Flap Intermediate from the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_88080 "Telomere C-strand synthesis initiation, Mus musculus"
xref: Reactome:REACT_88200 "Formation of the Flap Intermediate on the C-strand, Canis familiaris"
xref: Reactome:REACT_88586 "RPA binds to the Flap on the C-strand, Rattus norvegicus"
xref: Reactome:REACT_88760 "Removal of remaining Flap from the C-strand, Sus scrofa"
xref: Reactome:REACT_88793 "RPA binds to the Flap on the C-strand, Bos taurus"
xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio"
xref: Reactome:REACT_89109 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_89136 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_89422 "RPA binds to the Flap on the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_89618 "Joining of adjacent Okazaki fragments of the C-strand, Rattus norvegicus"
xref: Reactome:REACT_89731 "Polymerase switching on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_89859 "Polymerase switching on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus"
xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_90507 "Polymerase switching on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_90656 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa"
xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus"
xref: Reactome:REACT_91568 "Recruitment of Dna2 endonuclease to the C strand, Bos taurus"
xref: Reactome:REACT_91624 "Telomere C-strand synthesis initiation, Saccharomyces cerevisiae"
xref: Reactome:REACT_91633 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Gallus gallus"
xref: Reactome:REACT_91661 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Caenorhabditis elegans"
xref: Reactome:REACT_92017 "Telomere C-strand synthesis initiation, Arabidopsis thaliana"
xref: Reactome:REACT_92092 "Joining of adjacent Okazaki fragments of the C-strand, Sus scrofa"
xref: Reactome:REACT_92189 "Processive synthesis on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_92339 "Removal of remaining Flap from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_92420 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_92505 "Removal of the Flap Intermediate from the C-strand, Rattus norvegicus"
xref: Reactome:REACT_92773 "Formation of Processive Complex on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_93121 "Polymerase switching on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana"
xref: Reactome:REACT_93603 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Taeniopygia guttata"
xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_93682 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_93745 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Schizosaccharomyces pombe"
xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_93893 "Removal of the Flap Intermediate from the C-strand, Bos taurus"
xref: Reactome:REACT_94317 "Joining of adjacent Okazaki fragments of the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris"
xref: Reactome:REACT_94685 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Xenopus tropicalis"
xref: Reactome:REACT_94878 "Formation of the Flap Intermediate on the C-strand, Xenopus tropicalis"
xref: Reactome:REACT_94930 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_95256 "Polymerase switching on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_95355 "Polymerase switching on the C-strand of the telomere, Oryza sativa"
xref: Reactome:REACT_95570 "RPA binds to the Flap on the C-strand, Canis familiaris"
xref: Reactome:REACT_95593 "Telomere C-strand synthesis initiation, Bos taurus"
xref: Reactome:REACT_95767 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_95954 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_96276 "Removal of remaining Flap from the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana"
xref: Reactome:REACT_96454 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Saccharomyces cerevisiae"
xref: Reactome:REACT_96676 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_96810 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus"
xref: Reactome:REACT_97146 "Removal of remaining Flap from the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_97211 "Telomere C-strand synthesis initiation, Drosophila melanogaster"
xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis"
xref: Reactome:REACT_97574 "Formation of the Flap Intermediate on the C-strand, Arabidopsis thaliana"
xref: Reactome:REACT_97781 "Telomere C-strand synthesis initiation, Danio rerio"
xref: Reactome:REACT_97849 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere, Dictyostelium discoideum"
xref: Reactome:REACT_98163 "RFC dissociates after sliding clamp formation on the C-strand of the telomere, Mus musculus"
xref: Reactome:REACT_98508 "Telomere C-strand synthesis initiation, Oryza sativa"
xref: Reactome:REACT_98514 "Telomere C-strand synthesis initiation, Xenopus tropicalis"
xref: Reactome:REACT_98606 "Formation of Processive Complex on the C-strand of the telomere, Danio rerio"
xref: Reactome:REACT_98653 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Drosophila melanogaster"
xref: Reactome:REACT_98674 "Formation of Processive Complex on the C-strand of the telomere, Canis familiaris"
xref: Reactome:REACT_98759 "RFC binding displaces Pol Alpha on the C-strand of the telomere, Rattus norvegicus"
xref: Reactome:REACT_98885 "Formation of the Flap Intermediate on the C-strand, Schizosaccharomyces pombe"
xref: Reactome:REACT_99121 "Removal of the Flap Intermediate from the C-strand, Sus scrofa"
xref: Reactome:REACT_99658 "Processive synthesis on the C-strand of the telomere, Sus scrofa"
xref: Reactome:REACT_99801 "Polymerase switching on the C-strand of the telomere, Plasmodium falciparum"
xref: Reactome:REACT_99836 "Telomere C-strand synthesis initiation, Plasmodium falciparum"
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006312 ! mitotic recombination

[Term]
id: GO:0000723
name: telomere maintenance
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb]
xref: Reactome:REACT_102051 "Telomere Maintenance, Sus scrofa"
xref: Reactome:REACT_102166 "Telomere Maintenance, Schizosaccharomyces pombe"
xref: Reactome:REACT_103257 "Telomere Maintenance, Bos taurus"
xref: Reactome:REACT_103618 "Telomere Maintenance, Canis familiaris"
xref: Reactome:REACT_104398 "Telomere Maintenance, Dictyostelium discoideum"
xref: Reactome:REACT_105276 "Disassociation of Processive Complex and Completed Telomere End, Canis familiaris"
xref: Reactome:REACT_105401 "Packaging Of Telomere Ends, Rattus norvegicus"
xref: Reactome:REACT_105641 "Disassociation of Processive Complex and Completed Telomere End, Mus musculus"
xref: Reactome:REACT_107344 "Disassociation of Processive Complex and Completed Telomere End, Xenopus tropicalis"
xref: Reactome:REACT_109055 "Disassociation of Processive Complex and Completed Telomere End, Schizosaccharomyces pombe"
xref: Reactome:REACT_110319 "Telomere Maintenance, Rattus norvegicus"
xref: Reactome:REACT_115102 "Packaging Of Telomere Ends, Canis familiaris"
xref: Reactome:REACT_115503 "Packaging Of Telomere Ends, Danio rerio"
xref: Reactome:REACT_115535 "Telomere maintenance, Gallus gallus"
xref: Reactome:REACT_31996 "Disassociation of Processive Complex and Completed Telomere End, Rattus norvegicus"
xref: Reactome:REACT_32322 "Packaging Of Telomere Ends, Sus scrofa"
xref: Reactome:REACT_78001 "Telomere Maintenance, Danio rerio"
xref: Reactome:REACT_78680 "Telomere Maintenance, Saccharomyces cerevisiae"
xref: Reactome:REACT_7954 "Disassociation of Processive Complex and Completed Telomere End, Homo sapiens"
xref: Reactome:REACT_7963 "Packaging Of Telomere Ends, Homo sapiens"
xref: Reactome:REACT_7970 "Telomere Maintenance, Homo sapiens"
xref: Reactome:REACT_80940 "Telomere Maintenance, Plasmodium falciparum"
xref: Reactome:REACT_82431 "Disassociation of Processive Complex and Completed Telomere End, Danio rerio"
xref: Reactome:REACT_83277 "Disassociation of Processive Complex and Completed Telomere End, Bos taurus"
xref: Reactome:REACT_84888 "Telomere Maintenance, Mus musculus"
xref: Reactome:REACT_85317 "Disassociation of Processive Complex and Completed Telomere End, Oryza sativa"
xref: Reactome:REACT_85782 "Telomere Maintenance, Arabidopsis thaliana"
xref: Reactome:REACT_86038 "Telomere Maintenance, Drosophila melanogaster"
xref: Reactome:REACT_86194 "Disassociation of Processive Complex and Completed Telomere End, Arabidopsis thaliana"
xref: Reactome:REACT_87184 "Telomere Maintenance, Caenorhabditis elegans"
xref: Reactome:REACT_88530 "Packaging Of Telomere Ends, Mus musculus"
xref: Reactome:REACT_94176 "Telomere Maintenance, Gallus gallus"
xref: Reactome:REACT_94707 "Telomere Maintenance, Oryza sativa"
xref: Reactome:REACT_96013 "Telomere Maintenance, Taeniopygia guttata"
xref: Reactome:REACT_96166 "Telomere Maintenance, Xenopus tropicalis"
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032200 ! telomere organization
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0000724
name: double-strand break repair via homologous recombination
namespace: biological_process
alt_id: GO:0016924
def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
subset: gosubset_prok
synonym: "HDR" EXACT [GOC:vk]
synonym: "homologous recombinational repair" EXACT []
synonym: "homology-directed repair" EXACT [GOC:vk]
synonym: "HRR" EXACT []
synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah]
synonym: "Rhp51-dependent recombinational repair" EXACT []
xref: Reactome:REACT_103005 "Homologous Recombination Repair, Caenorhabditis elegans"
xref: Reactome:REACT_108237 "Homologous Recombination Repair, Saccharomyces cerevisiae"
xref: Reactome:REACT_115539 "Recruitment of repair and signaling proteins to double-strand breaks, Gallus gallus"
xref: Reactome:REACT_115585 "Homologous recombination repair of replication-dependent double-strand breaks, Gallus gallus"
xref: Reactome:REACT_115626 "Homologous DNA pairing and strand exchange, Gallus gallus"
xref: Reactome:REACT_115651 "ATM mediated response to DNA double-strand break, Gallus gallus"
xref: Reactome:REACT_115715 "ATM mediated phosphorylation of repair proteins, Gallus gallus"
xref: Reactome:REACT_115769 "Homologous recombination repair, Gallus gallus"
xref: Reactome:REACT_115931 "Processing of DNA double-strand break ends, Gallus gallus"
xref: Reactome:REACT_115936 "Homologous recombination repair (HRR) of replication-independent double-strand breaks, Gallus gallus"
xref: Reactome:REACT_1874 "Homologous Recombination Repair, Homo sapiens"
xref: Reactome:REACT_29815 "Homologous Recombination Repair, Sus scrofa"
xref: Reactome:REACT_33853 "Homologous Recombination Repair, Oryza sativa"
xref: Reactome:REACT_42307 "Homologous Recombination Repair, Gallus gallus"
xref: Reactome:REACT_80576 "Homologous Recombination Repair, Schizosaccharomyces pombe"
xref: Reactome:REACT_82771 "Homologous Recombination Repair, Xenopus tropicalis"
xref: Reactome:REACT_83941 "Homologous Recombination Repair, Plasmodium falciparum"
xref: Reactome:REACT_84594 "Homologous Recombination Repair, Dictyostelium discoideum"
xref: Reactome:REACT_84793 "Homologous Recombination Repair, Danio rerio"
xref: Reactome:REACT_85965 "Homologous Recombination Repair, Drosophila melanogaster"
xref: Reactome:REACT_87979 "Homologous Recombination Repair, Mycobacterium tuberculosis"
xref: Reactome:REACT_90944 "Homologous Recombination Repair, Mus musculus"
xref: Reactome:REACT_92384 "Homologous Recombination Repair, Canis familiaris"
xref: Reactome:REACT_92897 "Homologous Recombination Repair, Arabidopsis thaliana"
xref: Reactome:REACT_97339 "Homologous Recombination Repair, Taeniopygia guttata"
xref: Reactome:REACT_99066 "Homologous Recombination Repair, Rattus norvegicus"
xref: Reactome:REACT_99423 "Homologous Recombination Repair, Bos taurus"
is_a: GO:0000725 ! recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0000725
name: recombinational repair
namespace: biological_process
def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
xref: Wikipedia:Recombinational_repair
is_a: GO:0006281 ! DNA repair
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0000726
name: non-recombinational repair
namespace: biological_process
def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000727
name: double-strand break repair via break-induced replication
namespace: biological_process
def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]
subset: gosubset_prok
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0000728
name: gene conversion at mating-type locus, DNA double-strand break formation
namespace: biological_process
def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483]
is_a: GO:0048610 ! cellular process involved in reproduction
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000729
name: DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]
xref: Reactome:REACT_172 "Resection of double-strand break ends, Homo sapiens"
is_a: GO:0000738 ! DNA catabolic process, exonucleolytic
intersection_of: GO:0000738 ! DNA catabolic process, exonucleolytic
intersection_of: part_of GO:0006302 ! double-strand break repair
relationship: part_of GO:0006302 ! double-strand break repair

[Term]
id: GO:0000730
name: DNA recombinase assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855]
synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw]
xref: Reactome:REACT_100225 "Assembly of the RAD51-ssDNA nucleoprotein complex, Gallus gallus"
xref: Reactome:REACT_100616 "Assembly of the RAD51-ssDNA nucleoprotein complex, Plasmodium falciparum"
xref: Reactome:REACT_101062 "Assembly of the RAD51-ssDNA nucleoprotein complex, Arabidopsis thaliana"
xref: Reactome:REACT_102016 "Assembly of the RAD51-ssDNA nucleoprotein complex, Dictyostelium discoideum"
xref: Reactome:REACT_103788 "Assembly of the RAD51-ssDNA nucleoprotein complex, Drosophila melanogaster"
xref: Reactome:REACT_104366 "Assembly of the RAD51-ssDNA nucleoprotein complex, Schizosaccharomyces pombe"
xref: Reactome:REACT_106498 "Assembly of the RAD51-ssDNA nucleoprotein complex, Taeniopygia guttata"
xref: Reactome:REACT_110494 "Assembly of the RAD51-ssDNA nucleoprotein complex, Mus musculus"
xref: Reactome:REACT_2141 "Assembly of the RAD51-ssDNA nucleoprotein complex, Homo sapiens"
xref: Reactome:REACT_28107 "Assembly of the RAD51-ssDNA nucleoprotein complex, Saccharomyces cerevisiae"
xref: Reactome:REACT_32257 "Assembly of the RAD51-ssDNA nucleoprotein complex, Bos taurus"
xref: Reactome:REACT_78586 "Assembly of the RAD51-ssDNA nucleoprotein complex, Canis familiaris"
xref: Reactome:REACT_79561 "Assembly of the RAD51-ssDNA nucleoprotein complex, Sus scrofa"
xref: Reactome:REACT_81810 "Assembly of the RAD51-ssDNA nucleoprotein complex, Xenopus tropicalis"
xref: Reactome:REACT_82066 "Assembly of the RAD51-ssDNA nucleoprotein complex, Caenorhabditis elegans"
xref: Reactome:REACT_85201 "Assembly of the RAD51-ssDNA nucleoprotein complex, Oryza sativa"
xref: Reactome:REACT_88197 "Assembly of the RAD51-ssDNA nucleoprotein complex, Rattus norvegicus"
xref: Reactome:REACT_96901 "Assembly of the RAD51-ssDNA nucleoprotein complex, Danio rerio"
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0000731
name: DNA synthesis involved in DNA repair
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855]
subset: gosubset_prok
synonym: "DNA repair synthesis" BROAD []
synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb]
synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah]
xref: Reactome:REACT_973 "DNA repair synthesis, Homo sapiens"
is_a: GO:0071897 ! DNA biosynthetic process
intersection_of: GO:0071897 ! DNA biosynthetic process
intersection_of: part_of GO:0006281 ! DNA repair
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0000732
name: strand displacement
namespace: biological_process
def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855]
subset: gosubset_prok
synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw]
synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw]
xref: Reactome:REACT_287 "Dissociation of the extended strands, Homo sapiens"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000733
name: DNA strand renaturation
namespace: biological_process
def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0000734
name: gene conversion at mating-type locus, DNA repair synthesis
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh]
is_a: GO:0000731 ! DNA synthesis involved in DNA repair
is_a: GO:0048610 ! cellular process involved in reproduction
intersection_of: GO:0000731 ! DNA synthesis involved in DNA repair
intersection_of: part_of GO:0007534 ! gene conversion at mating-type locus
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000735
name: removal of nonhomologous ends
namespace: biological_process
def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000736
name: double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
subset: gosubset_prok
is_a: GO:0000735 ! removal of nonhomologous ends
intersection_of: GO:0000735 ! removal of nonhomologous ends
intersection_of: part_of GO:0045002 ! double-strand break repair via single-strand annealing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0000737
name: DNA catabolic process, endonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, endonucleolytic" EXACT []
synonym: "DNA degradation, endonucleolytic" EXACT []
synonym: "endonucleolytic degradation of DNA" EXACT []
synonym: "endonucleolytic DNA catabolism" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis

[Term]
id: GO:0000738
name: DNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, exonucleolytic" EXACT []
synonym: "DNA degradation, exonucleolytic" EXACT []
synonym: "exonucleolytic degradation of DNA" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis

[Term]
id: GO:0000739
name: DNA strand annealing activity
namespace: molecular_function
def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0003697 ! single-stranded DNA binding
relationship: part_of GO:0000733 ! DNA strand renaturation

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0006997 ! nucleus organization

[Term]
id: GO:0000742
name: karyogamy involved in conjugation with cellular fusion
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh]
synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
is_a: GO:0048610 ! cellular process involved in reproduction
intersection_of: GO:0000741 ! karyogamy
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000743
name: nuclear migration involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0006946
def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt]
synonym: "nuclear congression" BROAD []
synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
is_a: GO:0048610 ! cellular process involved in reproduction
intersection_of: GO:0007097 ! nuclear migration
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000744
name: karyogamy involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh]
synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000741 ! karyogamy
intersection_of: GO:0000741 ! karyogamy
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000745
name: nuclear migration involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah]
synonym: "nuclear exchange during conjugation without cellular fusion" RELATED []
synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007097 ! nuclear migration
intersection_of: GO:0007097 ! nuclear migration
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000747
name: conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007322
alt_id: GO:0007333
alt_id: GO:0030461
alt_id: GO:0030477
def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: goslim_pombe
synonym: "cell fusion" RELATED []
synonym: "mating" RELATED []
is_a: GO:0000746 ! conjugation
is_a: GO:0019953 ! sexual reproduction

[Term]
id: GO:0000748
name: conjugation with mutual genetic exchange
namespace: biological_process
def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh]
synonym: "conjugation without cellular fusion" EXACT []
is_a: GO:0000746 ! conjugation

[Term]
id: GO:0000749
name: response to pheromone involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007328
alt_id: GO:0030434
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0048610 ! cellular process involved in reproduction
is_a: GO:0070887 ! cellular response to chemical stimulus
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000750
name: pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007330
alt_id: GO:0030454
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "transduction of mating signal" BROAD []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
is_a: GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000751
name: cell cycle arrest in response to pheromone
namespace: biological_process
alt_id: GO:0030571
def: "The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:tb]
is_a: GO:0007050 ! cell cycle arrest
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000752
name: agglutination involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007334
def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh]
synonym: "agglutination" BROAD []
synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT []
synonym: "cell-cell adhesion during mating" EXACT []
is_a: GO:0000771 ! agglutination involved in conjugation
is_a: GO:0048610 ! cellular process involved in reproduction
intersection_of: GO:0016337 ! cell-cell adhesion
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000753
name: cell morphogenesis involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007332
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt]
synonym: "shmoo orientation" NARROW []
synonym: "shmooing" NARROW []
is_a: GO:0000767 ! cell morphogenesis involved in conjugation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048610 ! cellular process involved in reproduction
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000747 ! conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion

[Term]
id: GO:0000754
name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007331
alt_id: GO:0030453
def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt]
synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT []
is_a: GO:0000749 ! response to pheromone involved in conjugation with cellular fusion
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0000755
name: cytogamy
namespace: biological_process
alt_id: GO:0000218
alt_id: GO:0030462
def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
synonym: "zygote formation" RELATED []
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000756
name: response to pheromone involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt]
synonym: "response to pheromone involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007154 ! cell communication
is_a: GO:0019236 ! response to pheromone
is_a: GO:0070887 ! cellular response to chemical stimulus
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000757
name: signal transduction involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt]
synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000758
name: agglutination involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh]
synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000771 ! agglutination involved in conjugation
intersection_of: GO:0000771 ! agglutination involved in conjugation
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000759
name: cell morphogenesis involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt]
synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000767 ! cell morphogenesis involved in conjugation
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000748 ! conjugation with mutual genetic exchange
relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange

[Term]
id: GO:0000760
name: adaptation to pheromone involved in conjugation with mutual genetic exchange
namespace: biological_process
def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT []
is_a: GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange
is_a: GO:0022401 ! negative adaptation of signaling pathway

[Term]
id: GO:0000761
name: conjugant formation
namespace: biological_process
def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000762
name: pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh]
is_a: GO:0009291 ! unidirectional conjugation

[Term]
id: GO:0000763
name: cell morphogenesis involved in unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
is_obsolete: true

[Term]
id: GO:0000764
name: cellular morphogenesis involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt]
comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur.
synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0000765
name: response to pheromone involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation." [GOC:clt]
synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb]
is_a: GO:0019236 ! response to pheromone
intersection_of: GO:0019236 ! response to pheromone
intersection_of: part_of GO:0000762 ! pheromone-induced unidirectional conjugation
relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation

[Term]
id: GO:0000766
name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb]
synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT []
synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0000765 ! response to pheromone involved in pheromone-induced unidirectional conjugation
is_a: GO:0022401 ! negative adaptation of signaling pathway

[Term]
id: GO:0000767
name: cell morphogenesis involved in conjugation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0000746 ! conjugation
relationship: part_of GO:0000746 ! conjugation

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" EXACT []
is_a: GO:0006949 ! syncytium formation
relationship: has_part GO:0045026 ! plasma membrane fusion

[Term]
id: GO:0000769
name: syncytium formation by mitosis without cytokinesis
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb]
synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah]
is_a: GO:0006949 ! syncytium formation
relationship: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis

[Term]
id: GO:0000770
name: peptide pheromone export
namespace: biological_process
alt_id: GO:0007325
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh]
synonym: "a-factor export" NARROW []
synonym: "peptide pheromone secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0000771
name: agglutination involved in conjugation
namespace: biological_process
def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh]
is_a: GO:0007157 ! heterophilic cell-cell adhesion
relationship: part_of GO:0000746 ! conjugation

[Term]
id: GO:0000772
name: mating pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh]
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0000773
name: phosphatidyl-N-methylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71]
subset: gosubset_prok
synonym: "methyltransferase II" RELATED [EC:2.1.1.71]
synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71]
synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "PLMT" EXACT []
synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71]
xref: EC:2.1.1.71
xref: MetaCyc:2.1.1.71-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000774
name: adenyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0000775
name: chromosome, centromeric region
namespace: cellular_component
def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "centromere" RELATED []
synonym: "chromosome, centric region" EXACT []
synonym: "chromosome, pericentric region" RELATED []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
alt_id: GO:0005699
def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Kinetochore
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0000777
name: condensed chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000776 ! kinetochore
intersection_of: GO:0000776 ! kinetochore
intersection_of: part_of GO:0000793 ! condensed chromosome
relationship: part_of GO:0000779 ! condensed chromosome, centromeric region

[Term]
id: GO:0000778
name: condensed nuclear chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000777 ! condensed chromosome kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000776 ! kinetochore
intersection_of: part_of GO:0000794 ! condensed nuclear chromosome
relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region

[Term]
id: GO:0000779
name: condensed chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed chromosome, centric region" EXACT []
synonym: "condensed chromosome, centromere" RELATED []
synonym: "condensed chromosome, pericentric region" RELATED []
is_a: GO:0000775 ! chromosome, centromeric region
intersection_of: GO:0000775 ! chromosome, centromeric region
intersection_of: part_of GO:0000793 ! condensed chromosome
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000780
name: condensed nuclear chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed nuclear chromosome, centric region" EXACT []
synonym: "condensed nuclear chromosome, centromere" RELATED []
synonym: "condensed nuclear chromosome, pericentric region" RELATED []
is_a: GO:0000779 ! condensed chromosome, centromeric region
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000779 ! condensed chromosome, centromeric region
intersection_of: part_of GO:0000794 ! condensed nuclear chromosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000781
name: chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "telomere" RELATED []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0000783
name: nuclear telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0000782 ! telomere cap complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000782 ! telomere cap complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0000784
name: nuclear chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "nuclear chromosome, telomere" EXACT []
is_a: GO:0000781 ! chromosome, telomeric region
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000781 ! chromosome, telomeric region
intersection_of: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
alt_id: GO:0005717
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130]
synonym: "chromosome scaffold" RELATED []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
alt_id: GO:0005718
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Nucleosome
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000787
name: cytoplasmic nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000786 ! nucleosome
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000789 ! cytoplasmic chromatin

[Term]
id: GO:0000788
name: nuclear nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000786 ! nucleosome
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000789
name: cytoplasmic chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm." [GOC:elh, PMID:20404130]
is_a: GO:0000785 ! chromatin
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000785 ! chromatin
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000790
name: nuclear chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130]
is_a: GO:0000785 ! chromatin
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000785 ! chromatin
intersection_of: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
def: "A compact and highly condensed form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000793
name: condensed chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
synonym: "cytoplasmic mitotic chromosome" RELATED []
synonym: "metaphase chromosome" RELATED []
synonym: "mitotic chromosome" RELATED []
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000794
name: condensed nuclear chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh]
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
synonym: "meiotic chromosome" RELATED []
synonym: "nuclear mitotic chromosome" RELATED []
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000793 ! condensed chromosome
intersection_of: GO:0000793 ! condensed chromosome
intersection_of: part_of GO:0005634 ! nucleus

[Term]
id: GO:0000795
name: synaptonemal complex
namespace: cellular_component
alt_id: GO:0005716
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
xref: Wikipedia:Synaptonemal_complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
alt_id: GO:0005676
alt_id: GO:0008620
def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
subset: goslim_pir
synonym: "13S condensin complex" NARROW []
synonym: "SMC complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000797
name: condensin core heterodimer
namespace: cellular_component
alt_id: GO:0008621
def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
synonym: "8S condensin complex" NARROW []
synonym: "Smc2-Smc4 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
intersection_of: GO:0043234 ! protein complex
intersection_of: part_of GO:0000796 ! condensin complex
relationship: part_of GO:0000796 ! condensin complex

[Term]
id: GO:0000798
name: nuclear cohesin complex
namespace: cellular_component
def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh]
comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0008278 ! cohesin complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0008278 ! cohesin complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000799
name: nuclear condensin complex
namespace: cellular_component
def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh]
is_a: GO:0000796 ! condensin complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000796 ! condensin complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000800
name: lateral element
namespace: cellular_component
def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh]
synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000801
name: central element
namespace: cellular_component
def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000802
name: transverse filament
namespace: cellular_component
def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000804
name: W chromosome
namespace: cellular_component
def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000805
name: X chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:X_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000806
name: Y chromosome
namespace: cellular_component
def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:Y_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000807
name: Z chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: goslim_pir
subset: gosubset_prok
synonym: "ORC" EXACT []
synonym: "origin of replication recognition complex" EXACT []
xref: Wikipedia:Origin_recognition_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000809
name: cytoplasmic origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh]
subset: gosubset_prok
synonym: "cytoplasmic ORC" EXACT []
synonym: "prokaryotic ORC" RELATED []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044444 ! cytoplasmic part
intersection_of: GO:0000808 ! origin recognition complex
intersection_of: part_of GO:0005737 ! cytoplasm
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000810
name: diacylglycerol diphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [EC:3.1.3.81, GOC:kad, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443]
comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two.
synonym: "DGPP phosphatase activity" EXACT []
synonym: "DGPP phosphohydrolase activity" EXACT []
synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT []
xref: EC:3.1.3.81
xref: MetaCyc:RXN-11277
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000811
name: GINS complex
namespace: cellular_component
def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]
synonym: "Go, Ichi, Ni and San complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000812
name: Swr1 complex
namespace: cellular_component
def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608]
synonym: "SWR-C" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000813
name: ESCRT I complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000814
name: ESCRT II complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000815
name: ESCRT III complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000817
name: COMA complex
namespace: cellular_component
def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972]
synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000818
name: nuclear MIS12/MIND type complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972]
synonym: "MIND complex" EXACT []
synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT []
is_a: GO:0000444 ! MIS12/MIND type complex
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000444 ! MIS12/MIND type complex
intersection_of: part_of GO:0005634 ! nucleus
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0007059 ! chromosome segregation
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0000820
name: regulation of glutamine family amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]
synonym: "regulation of glutamine family amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009064 ! glutamine family amino acid metabolic process
relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0000821
name: regulation of arginine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators]
synonym: "regulation of arginine metabolism" EXACT []
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006525 ! arginine metabolic process
relationship: regulates GO:0006525 ! arginine metabolic process

[Term]
id: GO:0000822
name: inositol hexakisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators]
synonym: "InsP6 binding" EXACT []
synonym: "IP6 binding" EXACT []
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0000823
name: inositol-1,4,5-trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN]
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "inositol trisphosphate 6-kinase activity" BROAD []
synonym: "IpmK" BROAD []
xref: EC:2.7.1.151
xref: KEGG:R05800
xref: MetaCyc:2.7.1.151-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0000824
name: inositol tetrakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "EC:2.7.1.151" BROAD []
synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "IpmK" BROAD []
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000825
name: inositol tetrakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT []
synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT []
xref: MetaCyc:RXN-7184
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000826
name: inositol pyrophosphate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326]
comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them.
synonym: "inositol diphosphate synthase activity" EXACT []
is_obsolete: true
consider: GO:0052746

[Term]
id: GO:0000827
name: inositol-1,3,4,5,6-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242]
synonym: "EC:2.7.4.21" BROAD []
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000828
name: inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, PMID:16429326]
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000829
name: inositol heptakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326]
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000830
name: inositol hexakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000831
name: inositol hexakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000832
name: inositol hexakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN]
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT []
xref: EC:2.7.4.21
xref: KEGG:R09087
xref: MetaCyc:2.7.1.152-RXN
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000833
name: inositol heptakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326]
synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT []
synonym: "IP7 4-kinase activity" EXACT []
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0000834
name: inositol heptakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0000835
name: ER ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the ER." [GOC:elh]
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
intersection_of: GO:0000151 ! ubiquitin ligase complex
intersection_of: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0000836
name: Hrd1p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000837
name: Doa10p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066]
synonym: "Ssm4p ubiquitin ligase complex" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000838
name: Hrd1p ubiquitin ligase ERAD-M complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000839
name: Hrd1p ubiquitin ligase ERAD-L complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000900
name: translation repressor activity, nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0000901
name: translation repressor activity, non-nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0000903
name: regulation of cell shape during vegetative growth phase
namespace: biological_process
alt_id: GO:0090061
def: "Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw]
synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw]
synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED []
is_a: GO:0008360 ! regulation of cell shape
relationship: part_of GO:0072690 ! vegetative growth of a single-celled organism

[Term]
id: GO:0000904
name: cell morphogenesis involved in differentiation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]
is_a: GO:0000902 ! cell morphogenesis
intersection_of: GO:0000902 ! cell morphogenesis
intersection_of: part_of GO:0048468 ! cell development
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0000905
name: sporocarp development involved in asexual reproduction
namespace: biological_process
def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu]
synonym: "conidium development" NARROW []
synonym: "fruiting body formation involved in asexual reproduction" BROAD []
synonym: "haploid fruiting" RELATED []
synonym: "homokaryotic fruiting" RELATED []
synonym: "imperfect stage fruiting body development" NARROW []
synonym: "monokaryotic fruiting" RELATED []
is_a: GO:0030584 ! sporocarp development
intersection_of: GO:0030584 ! sporocarp development
intersection_of: part_of GO:0019954 ! asexual reproduction
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0000906
name: 6,7-dimethyl-8-ribityllumazine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556]
synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX]
xref: EC:5.4.-.-
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0000907
name: sulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536]
subset: gosubset_prok
synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT []
synonym: "sulphonate dioxygenase activity" EXACT []
xref: EC:1.14.11.-
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0000908
name: taurine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15912]
subset: gosubset_prok
synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17]
xref: EC:1.14.11.17
xref: KEGG:R05320
xref: MetaCyc:RXN0-299
xref: RHEA:15912
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0000909
name: sporocarp development involved in sexual reproduction
namespace: biological_process
def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu]
synonym: "ascus development" NARROW []
synonym: "fruiting body development involved in sexual reproduction" BROAD []
synonym: "fruiting body formation involved in sexual reproduction" BROAD []
synonym: "perfect stage fruiting body development" NARROW []
is_a: GO:0030584 ! sporocarp development
intersection_of: GO:0030584 ! sporocarp development
intersection_of: part_of GO:0019953 ! sexual reproduction
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai]
comment: Note that most eukaryotic gene products involved in canonical cytokinesis during the cell cycle can be annotated to 'cell cycle cytokinesis ; GO:0033205' or its descendants. See also 'cell division ; GO:0051301'. Note that cytokinesis excludes nuclear division; in prokaryotes, there is little difference between cytokinesis and cell division.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101918 "Mitotic Telophase /Cytokinesis, Mus musculus"
xref: Reactome:REACT_108805 "Mitotic Telophase /Cytokinesis, Dictyostelium discoideum"
xref: Reactome:REACT_1932 "Mitotic Telophase /Cytokinesis, Homo sapiens"
xref: Reactome:REACT_30667 "Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe"
xref: Reactome:REACT_32636 "Mitotic Telophase /Cytokinesis, Bos taurus"
xref: Reactome:REACT_78494 "Mitotic Telophase /Cytokinesis, Danio rerio"
xref: Reactome:REACT_84722 "Mitotic Telophase /Cytokinesis, Gallus gallus"
xref: Reactome:REACT_87726 "Mitotic Telophase /Cytokinesis, Xenopus tropicalis"
xref: Reactome:REACT_92849 "Mitotic Telophase /Cytokinesis, Taeniopygia guttata"
xref: Reactome:REACT_93374 "Mitotic Telophase /Cytokinesis, Canis familiaris"
xref: Reactome:REACT_94382 "Mitotic Telophase /Cytokinesis, Drosophila melanogaster"
xref: Reactome:REACT_98952 "Mitotic Telophase /Cytokinesis, Rattus norvegicus"
xref: Reactome:REACT_99118 "Mitotic Telophase /Cytokinesis, Caenorhabditis elegans"
xref: Wikipedia:Cytokinesis
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0051301 ! cell division

[Term]
id: GO:0000911
name: cytokinesis by cell plate formation
namespace: biological_process
def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt]
is_a: GO:0033205 ! cell cycle cytokinesis

[Term]
id: GO:0000912
name: assembly of actomyosin apparatus involved in cell cycle cytokinesis
namespace: biological_process
def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:mah]
synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah]
synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb]
synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph]
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0071844 ! cellular component assembly at cellular level
relationship: part_of GO:0033205 ! cell cycle cytokinesis

[Term]
id: GO:0000913
name: preprophase band assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah]
synonym: "preprophase band formation" RELATED [GOC:mah]
is_a: GO:0007105 ! cytokinesis, site selection
is_a: GO:0071844 ! cellular component assembly at cellular level
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000914
name: phragmoplast assembly
namespace: biological_process
def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt]
synonym: "phragmoplast formation" RELATED [goc:dph]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000915
name: cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
alt_id: GO:0045573
def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
synonym: "constriction ring assembly" NARROW []
synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED []
synonym: "cytokinesis, actomyosin ring formation" RELATED []
synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis

[Term]
id: GO:0000916
name: actomyosin contractile ring contraction
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw]
synonym: "cytokinesis, actomyosin ring contraction" EXACT []
synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb]
is_a: GO:0036213 ! contractile ring contraction
relationship: part_of GO:0033205 ! cell cycle cytokinesis

[Term]
id: GO:0000917
name: barrier septum assembly
namespace: biological_process
def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt, GOC:mah]
synonym: "barrier septum formation" EXACT [GOC:mah]
synonym: "formation of barrier septum" EXACT []
synonym: "septation" BROAD []
synonym: "septin assembly and septum biosynthesis" RELATED []
synonym: "septin assembly and septum formation" RELATED []
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0071844 ! cellular component assembly at cellular level

[Term]
id: GO:0000918
name: barrier septum site selection
namespace: biological_process
def: "The process of marking the site where a barrier septum will form." [GOC:clt]
synonym: "selection of site for barrier cell septum biosynthesis" EXACT []
synonym: "selection of site for barrier cell septum formation" EXACT []
synonym: "selection of site for barrier septum formation" EXACT [GOC:curators]
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
synonym: "septum positioning" EXACT []
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000917 ! barrier septum assembly

[Term]
id: GO:0000919
name: cell plate assembly
namespace: biological_process
def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt]
synonym: "cell plate formation" RELATED [GOC:mah]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0071844 ! cellular component assembly at cellular level
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000920
name: cytokinetic cell separation
namespace: biological_process
def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt]
synonym: "cell separation during cytokinesis" RELATED [GOC:dph, GOC:tb]
synonym: "rotokinesis" NARROW []
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0000921
name: septin ring assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt]
subset: gosubset_prok
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0031106 ! septin ring organization

[Term]
id: GO:0000922
name: spindle pole
namespace: cellular_component
alt_id: GO:0030615
def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0000923
name: equatorial microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817]
synonym: "EMTOC" EXACT []
synonym: "equatorial microtubule organising centre" EXACT []
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0032155 ! cell division site part
intersection_of: GO:0005815 ! microtubule organizing center
intersection_of: part_of GO:0032153 ! cell division site

[Term]
id: GO:0000924
name: gamma-tubulin ring complex, centrosomal
namespace: cellular_component
alt_id: GO:0000925
alt_id: GO:0000926
def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256]
synonym: "gamma-tubulin large complex, centrosomal" EXACT []
is_a: GO:0008274 ! gamma-tubulin ring complex
intersection_of: GO:0008274 ! gamma-tubulin ring complex
intersection_of: part_of GO:0000242 ! pericentriolar material
relationship: part_of GO:0000242 ! pericentriolar material

[Term]
id: GO:0000927
name: gamma-tubulin small complex, centrosomal
namespace: cellular_component
def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0008275 ! gamma-tubulin small complex

[Term]
id: GO:0000928
name: gamma-tubulin small complex, spindle pole body
namespace: cellular_component
def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075]
synonym: "Tub4 complex" EXACT []
is_a: GO:0008275 ! gamma-tubulin small complex
intersection_of: GO:0008275 ! gamma-tubulin small complex
intersection_of: part_of GO:0005816 ! spindle pole body
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044450 ! microtubule organizing center part

[Term]
id: GO:0000931
name: gamma-tubulin large complex
namespace: cellular_component
alt_id: GO:0000929
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0000932
name: cytoplasmic mRNA processing body
namespace: cellular_component
def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
synonym: "cytoplasmic foci" RELATED []
synonym: "P body" EXACT []
synonym: "P-body" EXACT []
xref: Wikipedia:P_body
is_a: GO:0035770 ! ribonucleoprotein granule

[Term]
id: GO:0000933
name: adventitious septum
namespace: cellular_component
def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526]
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000934
name: porous cell septum
namespace: cellular_component
def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt]
synonym: "porous septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000935
name: barrier septum
namespace: cellular_component
def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt]
synonym: "complete septum" EXACT []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000936
name: primary cell septum
namespace: cellular_component
def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526]
synonym: "primary septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000937
name: dolipore septum
namespace: cellular_component
def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt]
is_a: GO:0000934 ! porous cell septum

[Term]
id: GO:0000938
name: GARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]
synonym: "Golgi associated retrograde protein complex" EXACT []
synonym: "VFT tethering complex" EXACT []
synonym: "Vps fifty three tethering complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0000939
name: condensed chromosome inner kinetochore
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983]
synonym: "inner centromere core complex" RELATED []
synonym: "inner kinetochore of condensed chromosome" EXACT [GOC:curators]
synonym: "inner kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000940
name: condensed chromosome outer kinetochore
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
synonym: "outer kinetochore of condensed chromosome" EXACT [GOC:curators]
synonym: "outer kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000941
name: condensed nuclear chromosome inner kinetochore
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398]
synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [GOC:curators]
is_a: GO:0000939 ! condensed chromosome inner kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000939 ! condensed chromosome inner kinetochore
intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000942
name: condensed nuclear chromosome outer kinetochore
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398]
synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [GOC:curators]
is_a: GO:0000940 ! condensed chromosome outer kinetochore
is_a: GO:0044454 ! nuclear chromosome part
intersection_of: GO:0000940 ! condensed chromosome outer kinetochore
intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000943
name: retrotransposon nucleocapsid
namespace: cellular_component
def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903]
synonym: "Virus-like particle" EXACT []
synonym: "VLP" EXACT []
xref: Wikipedia:Virus-like_particle
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000944
name: base pairing with rRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0000945
name: base pairing with snRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0000946
name: base pairing with tRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000049 ! tRNA binding
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000947
name: amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0000948
name: amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0000949
name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000950
name: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0000951
name: methionine catabolic process to 3-methylthiopropanol
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0000952
name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000953
name: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0000954
name: methionine catabolic process to 3-methylthiopropanoate
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0000955
name: amino acid catabolic process via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0000956
name: nuclear-transcribed mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]
synonym: "nuclear mRNA breakdown" EXACT []
synonym: "nuclear mRNA catabolism" EXACT []
synonym: "nuclear mRNA degradation" EXACT []
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000957
name: mitochondrial RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006401 ! RNA catabolic process
intersection_of: GO:0006401 ! RNA catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000958
name: mitochondrial mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0006402 ! mRNA catabolic process
intersection_of: GO:0006402 ! mRNA catabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000959
name: mitochondrial RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0016070 ! RNA metabolic process
intersection_of: GO:0016070 ! RNA metabolic process
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000960
name: regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000961
name: negative regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000962
name: positive regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process
relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000963
name: mitochondrial RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006396 ! RNA processing
is_a: GO:0007005 ! mitochondrion organization
intersection_of: GO:0006396 ! RNA processing
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000964
name: mitochondrial RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 5' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0000966 ! RNA 5'-end processing
intersection_of: GO:0000966 ! RNA 5'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000965
name: mitochondrial RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 3' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0031123 ! RNA 3'-end processing
intersection_of: GO:0031123 ! RNA 3'-end processing
intersection_of: occurs_in GO:0005739 ! mitochondrion

[Term]
id: GO:0000966
name: RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc]
synonym: "RNA 5' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0000967
name: rRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc]
synonym: "rRNA 5' end processing" EXACT []
is_a: GO:0034471 ! ncRNA 5'-end processing

[Term]
id: GO:0000968
name: tRNA exon ligation
namespace: biological_process
def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc]
is_a: GO:0000378 ! RNA exon ligation
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation
created_by: kchris
creation_date: 2009-04-28T10:22:40Z

[Term]
id: GO:0000969
name: tRNA exon ligation utilizing ATP as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:29:37Z

[Term]
id: GO:0000970
name: tRNA exon ligation utilizing GTP as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:33:25Z

[Term]
id: GO:0000971
name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
namespace: biological_process
def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation
created_by: kchris
creation_date: 2009-04-28T10:36:17Z

[Term]
id: GO:0000972
name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049]
is_a: GO:0051276 ! chromosome organization
created_by: kchris
creation_date: 2009-09-10T12:25:11Z

[Term]
id: GO:0000973
name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049]
is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
created_by: kchris
creation_date: 2009-09-10T12:28:04Z

[Term]
id: GO:0000974
name: Prp19 complex
namespace: cellular_component
def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]
synonym: "nineteen complex" NARROW []
synonym: "NTC" RELATED []
synonym: "Prp19/CDC5 complex" NARROW []
is_a: GO:0043234 ! protein complex
created_by: kchris
creation_date: 2009-10-12T10:01:30Z

[Term]
id: GO:0000975
name: regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0001067 ! regulatory region nucleic acid binding
is_a: GO:0003677 ! DNA binding
created_by: kchris
creation_date: 2010-08-10T10:56:24Z

[Term]
id: GO:0000976
name: transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0043565 ! sequence-specific DNA binding
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-10T11:00:02Z

[Term]
id: GO:0000977
name: RNA polymerase II regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-10T11:05:36Z

[Term]
id: GO:0000978
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH]
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED []
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:17:19Z

[Term]
id: GO:0000979
name: RNA polymerase II core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery." [GOC:txnOH]
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:17:28Z

[Term]
id: GO:0000980
name: RNA polymerase II distal enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH]
comment: Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers.
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:29:25Z

[Term]
id: GO:0000981
name: sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: has_part GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
relationship: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-08-10T02:37:21Z

[Term]
id: GO:0000982
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:txnOH]
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:39:46Z

[Term]
id: GO:0000983
name: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0000979 ! RNA polymerase II core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T02:47:56Z

[Term]
id: GO:0000984
name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED []
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-10T02:58:18Z

[Term]
id: GO:0000985
name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T03:01:38Z

[Term]
id: GO:0000986
name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-10T03:02:31Z

[Term]
id: GO:0000987
name: core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001159 ! core promoter proximal region DNA binding
created_by: kchris
creation_date: 2010-08-10T03:40:16Z

[Term]
id: GO:0000988
name: protein binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: high_level_annotation_qc
synonym: "transcription factor activity" BROAD []
is_a: GO:0003674 ! molecular_function
relationship: has_part GO:0005515 ! protein binding
relationship: part_of GO:2001141 ! regulation of RNA biosynthetic process
created_by: kchris
creation_date: 2010-08-10T04:03:22Z

[Term]
id: GO:0000989
name: transcription factor binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000988 ! protein binding transcription factor activity
relationship: has_part GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2010-08-10T04:57:43Z

[Term]
id: GO:0000990
name: core RNA polymerase binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000988 ! protein binding transcription factor activity
relationship: has_part GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-10T05:01:03Z

[Term]
id: GO:0000991
name: core RNA polymerase II binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity
relationship: has_part GO:0000993 ! RNA polymerase II core binding
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-08-10T05:03:45Z

[Term]
id: GO:0000992
name: polymerase III regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-11T03:49:28Z

[Term]
id: GO:0000993
name: RNA polymerase II core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH]
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
is_a: GO:0032403 ! protein complex binding
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-11T03:57:27Z

[Term]
id: GO:0000994
name: RNA polymerase III core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-11T03:58:58Z

[Term]
id: GO:0000995
name: core RNA polymerase III binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:12381659]
is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity
relationship: has_part GO:0000994 ! RNA polymerase III core binding
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-11T03:59:13Z

[Term]
id: GO:0000996
name: core DNA-dependent RNA polymerase binding promoter specificity activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs." [GOC:txnOH]
is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity
relationship: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-11T04:12:24Z

[Term]
id: GO:0000997
name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase." [GOC:txnOH]
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-17T04:48:40Z

[Term]
id: GO:0000999
name: RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001022 ! transcription initiation from RNA polymerase III type 1 promoter
created_by: kchris
creation_date: 2010-08-19T04:16:04Z

[Term]
id: GO:0001000
name: bacterial-type RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH]
comment: Should omega be included here?
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT []
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-08-17T04:59:00Z

[Term]
id: GO:0001001
name: mitochondrial single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding
created_by: kchris
creation_date: 2010-08-17T05:01:28Z

[Term]
id: GO:0001002
name: RNA polymerase III type 1 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T05:38:20Z

[Term]
id: GO:0001003
name: RNA polymerase III type 2 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T05:51:18Z

[Term]
id: GO:0001004
name: RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter." [GOC:txnOH, PMID:12381659]
is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity
is_a: GO:0001034 ! sequence-specific DNA binding RNA polymerase III transcription factor activity
is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity
relationship: has_part GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
relationship: has_part GO:0001154 ! TFIIIB-class transcription factor binding
created_by: kchris
creation_date: 2010-08-18T05:53:32Z

[Term]
id: GO:0001005
name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "TFIIIA activity" RELATED []
synonym: "TFIIIC-type activity" RELATED []
is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
relationship: has_part GO:0001002 ! RNA polymerase III type 1 promoter sequence-specific DNA binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-18T05:57:29Z

[Term]
id: GO:0001006
name: RNA polymerase III type 3 promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding
created_by: kchris
creation_date: 2010-08-18T06:02:26Z

[Term]
id: GO:0001007
name: RNA polymerase III transcription factor binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000989 ! transcription factor binding transcription factor activity
relationship: has_part GO:0001025 ! RNA polymerase III transcription factor binding
relationship: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-18T06:24:07Z

[Term]
id: GO:0001008
name: RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity." [GOC:txnOH, PMID:12381659]
synonym: "TFIIIC-type activity" RELATED []
synonym: "type 2 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
relationship: has_part GO:0001003 ! RNA polymerase III type 2 promoter sequence-specific DNA binding
relationship: part_of GO:0001021 ! RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-18T06:30:45Z

[Term]
id: GO:0001009
name: transcription from RNA polymerase III type 2 promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-18T06:37:56Z

[Term]
id: GO:0001010
name: sequence-specific DNA binding transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH]
is_a: GO:0001134 ! transcription factor recruiting transcription factor activity
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2010-08-18T06:46:33Z

[Term]
id: GO:0001011
name: sequence-specific DNA binding RNA polymerase recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2010-08-18T06:49:16Z

[Term]
id: GO:0001012
name: RNA polymerase II regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:43:58Z

[Term]
id: GO:0001013
name: RNA polymerase I regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:44:02Z

[Term]
id: GO:0001014
name: snoRNA transcription from a type 2 RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH]
is_a: GO:0001009 ! transcription from RNA polymerase III type 2 promoter
is_a: GO:0009302 ! snoRNA transcription
created_by: kchris
creation_date: 2010-08-18T07:13:45Z

[Term]
id: GO:0001015
name: snoRNA transcription from an RNA polymerase II promoter
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009302 ! snoRNA transcription
created_by: kchris
creation_date: 2010-08-18T07:21:18Z

[Term]
id: GO:0001016
name: RNA polymerase III regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, PMID:12381659]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:36:17Z

[Term]
id: GO:0001017
name: bacterial-type RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
subset: gosubset_prok
synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT []
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:45:42Z

[Term]
id: GO:0001018
name: mitochondrial RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors." [GOC:txnOH, PMID:20056105]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:46:22Z

[Term]
id: GO:0001019
name: plastid RNA polymerase regulatory region DNA binding
namespace: molecular_function
def: "Interacting selectively with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-19T09:46:27Z

[Term]
id: GO:0001020
name: RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001024 ! transcription initiation from RNA polymerase III type 3 promoter
created_by: kchris
creation_date: 2010-08-19T04:18:46Z

[Term]
id: GO:0001021
name: RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
relationship: part_of GO:0001023 ! transcription initiation from RNA polymerase III type 2 promoter
created_by: kchris
creation_date: 2010-08-19T04:18:53Z

[Term]
id: GO:0001022
name: transcription initiation from RNA polymerase III type 1 promoter
namespace: biological_process
def: "A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0042791 ! 5S class rRNA transcription from RNA polymerase III type 1 promoter
created_by: kchris
creation_date: 2010-08-19T04:33:52Z

[Term]
id: GO:0001023
name: transcription initiation from RNA polymerase III type 2 promoter
namespace: biological_process
def: "A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001009 ! transcription from RNA polymerase III type 2 promoter
created_by: kchris
creation_date: 2010-08-19T04:35:09Z

[Term]
id: GO:0001024
name: transcription initiation from RNA polymerase III type 3 promoter
namespace: biological_process
def: "A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001035 ! transcription from RNA polymerase III type 3 promoter
created_by: kchris
creation_date: 2010-08-19T04:35:14Z

[Term]
id: GO:0001025
name: RNA polymerase III transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2010-08-20T03:26:50Z

[Term]
id: GO:0001026
name: TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH]
synonym: "RNA polymerase III recruiting transcription factor activity" EXACT []
is_a: GO:0000995 ! core RNA polymerase III binding transcription factor activity
is_a: GO:0001007 ! RNA polymerase III transcription factor binding transcription factor activity
relationship: has_part GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T12:24:31Z

[Term]
id: GO:0001027
name: RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001030 ! RNA polymerase III type 1 promoter DNA binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:50:20Z

[Term]
id: GO:0001028
name: RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001031 ! RNA polymerase III type 2 promoter DNA binding
relationship: part_of GO:0001021 ! RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:52:01Z

[Term]
id: GO:0001029
name: RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED []
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001032 ! RNA polymerase III type 3 promoter DNA binding
relationship: part_of GO:0001020 ! RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T12:52:40Z

[Term]
id: GO:0001030
name: RNA polymerase III type 1 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
is_a: GO:0080084 ! 5S rDNA binding
created_by: kchris
creation_date: 2010-08-23T12:58:54Z

[Term]
id: GO:0001031
name: RNA polymerase III type 2 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T01:14:56Z

[Term]
id: GO:0001032
name: RNA polymerase III type 3 promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-23T01:15:14Z

[Term]
id: GO:0001033
name: RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIC.
synonym: "SNAPc-type activity" RELATED []
synonym: "type 3 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
relationship: has_part GO:0001006 ! RNA polymerase III type 3 promoter sequence-specific DNA binding
relationship: part_of GO:0001020 ! RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T03:04:17Z

[Term]
id: GO:0001034
name: sequence-specific DNA binding RNA polymerase III transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:12381659]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0006359 ! regulation of transcription from RNA polymerase III promoter
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-23T03:41:48Z

[Term]
id: GO:0001035
name: transcription from RNA polymerase III type 3 promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659]
synonym: "U6 snRNA transcription (mammalian)" NARROW []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-23T04:17:41Z

[Term]
id: GO:0001036
name: transcription initiation from RNA polymerase III hybrid type promoter
namespace: biological_process
def: "A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0006384 ! transcription initiation from RNA polymerase III promoter
relationship: part_of GO:0001041 ! transcription from a RNA polymerase III hybrid type promoter
created_by: kchris
creation_date: 2010-08-23T06:08:55Z

[Term]
id: GO:0001037
name: RNA polymerase III hybrid type promoter DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-24T02:51:34Z

[Term]
id: GO:0001038
name: RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
is_a: GO:0001004 ! RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity
relationship: has_part GO:0001039 ! RNA polymerase III hybrid type promoter sequence-specific DNA binding
relationship: part_of GO:0001043 ! RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T06:17:33Z

[Term]
id: GO:0001039
name: RNA polymerase III hybrid type promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding
is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding
created_by: kchris
creation_date: 2010-08-23T06:21:24Z

[Term]
id: GO:0001040
name: RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH, PMID:12381659]
is_a: GO:0001026 ! TFIIIB-type transcription factor activity
relationship: has_part GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding
relationship: part_of GO:0001043 ! RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-23T06:28:23Z

[Term]
id: GO:0001041
name: transcription from a RNA polymerase III hybrid type promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659]
synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-08-24T02:11:52Z

[Term]
id: GO:0001042
name: RNA polymerase I core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:39:23Z

[Term]
id: GO:0001043
name: RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene." [GOC:txnOH, PMID:12381659]
is_a: GO:0070898 ! RNA polymerase III transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-08-24T02:19:52Z

[Term]
id: GO:0001044
name: mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001018 ! mitochondrial RNA polymerase regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-25T04:11:49Z

[Term]
id: GO:0001045
name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase." [GOC:txnOH, PMID:20670382]
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2010-08-25T04:13:36Z

[Term]
id: GO:0001046
name: core promoter sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001047 ! core promoter binding
created_by: kchris
creation_date: 2010-08-25T04:17:44Z

[Term]
id: GO:0001047
name: core promoter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2010-08-27T03:00:52Z

[Term]
id: GO:0001048
name: RNA polymerase IV core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:41:03Z

[Term]
id: GO:0001049
name: RNA polymerase V core binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459]
is_a: GO:0043175 ! RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T01:41:08Z

[Term]
id: GO:0001050
name: single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
synonym: "SP6-type RNA polymerase binding" EXACT []
synonym: "T3-type RNA polymerase binding" EXACT []
synonym: "T3/T7 type RNA polymerase binding" EXACT []
synonym: "T7-type RNA polymerase binding" EXACT []
is_a: GO:0070063 ! RNA polymerase binding
created_by: kchris
creation_date: 2010-09-23T02:33:45Z

[Term]
id: GO:0001051
name: plastid single-subunit type RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995]
is_a: GO:0001050 ! single-subunit type RNA polymerase binding
created_by: kchris
creation_date: 2010-09-23T02:42:57Z

[Term]
id: GO:0001052
name: plastid PEP RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995]
is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T02:49:31Z

[Term]
id: GO:0001053
name: plastid sigma factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a plastid PEP core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of plastid PEP core promoter DNA sequence motifs." [GOC:txnOH, PMID:20701995]
subset: gosubset_prok
synonym: "sigma transcription factor" RELATED []
is_a: GO:0016987 ! sigma factor activity
relationship: has_part GO:0001052 ! plastid PEP RNA polymerase core enzyme binding
created_by: kchris
creation_date: 2010-09-23T03:03:00Z

[Term]
id: GO:0001054
name: RNA polymerase I activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006360 ! transcription from RNA polymerase I promoter
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2010-09-23T03:36:11Z

[Term]
id: GO:0001055
name: RNA polymerase II activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006366 ! transcription from RNA polymerase II promoter
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-09-23T03:44:23Z

[Term]
id: GO:0001056
name: RNA polymerase III activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0006383 ! transcription from RNA polymerase III promoter
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-09-23T03:44:47Z

[Term]
id: GO:0001057
name: RNA polymerase IV activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0001059 ! transcription from RNA polymerase IV promoter
relationship: part_of GO:0001059 ! transcription from RNA polymerase IV promoter
created_by: kchris
creation_date: 2010-09-23T03:44:55Z

[Term]
id: GO:0001058
name: RNA polymerase V activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: GO:0003899 ! DNA-directed RNA polymerase activity
intersection_of: part_of GO:0001060 ! transcription from RNA polymerase V promoter
relationship: part_of GO:0001060 ! transcription from RNA polymerase V promoter
created_by: kchris
creation_date: 2010-09-23T03:45:01Z

[Term]
id: GO:0001059
name: transcription from RNA polymerase IV promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol IV promoter" EXACT []
is_a: GO:0006351 ! transcription, DNA-dependent
created_by: kchris
creation_date: 2010-09-23T03:51:35Z

[Term]
id: GO:0001060
name: transcription from RNA polymerase V promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459]
synonym: "transcription from RNA pol V promoter" EXACT []
is_a: GO:0006351 ! transcription, DNA-dependent
created_by: kchris
creation_date: 2010-09-23T03:54:04Z

[Term]
id: GO:0001061
name: bacterial-type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-10-19T03:36:01Z

[Term]
id: GO:0001062
name: plastid PEP-A RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001061 ! bacterial-type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:38:49Z

[Term]
id: GO:0001063
name: plastid PEP-B RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001061 ! bacterial-type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:46:46Z

[Term]
id: GO:0001064
name: single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
synonym: "T3/T7 type RNA polymerase activity" EXACT []
is_a: GO:0003899 ! DNA-directed RNA polymerase activity
created_by: kchris
creation_date: 2010-10-19T03:47:56Z

[Term]
id: GO:0001065
name: mitochondrial single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type mitochondrial RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH]
is_a: GO:0001064 ! single subunit type RNA polymerase activity
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter
created_by: kchris
creation_date: 2010-10-19T03:50:51Z

[Term]
id: GO:0001066
name: plastid single subunit type RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995]
is_a: GO:0001064 ! single subunit type RNA polymerase activity
relationship: part_of GO:0042793 ! transcription from plastid promoter
created_by: kchris
creation_date: 2010-10-19T03:54:57Z

[Term]
id: GO:0001067
name: regulatory region nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0003676 ! nucleic acid binding
created_by: kchris
creation_date: 2010-10-21T04:08:56Z

[Term]
id: GO:0001068
name: transcription regulatory region RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0001069 ! regulatory region RNA binding
created_by: kchris
creation_date: 2010-10-21T04:15:32Z

[Term]
id: GO:0001069
name: regulatory region RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH]
is_a: GO:0001067 ! regulatory region nucleic acid binding
is_a: GO:0003723 ! RNA binding
created_by: kchris
creation_date: 2010-10-21T04:17:01Z

[Term]
id: GO:0001070
name: RNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:8332211]
synonym: "transcription factor activity" BROAD []
is_a: GO:0001071 ! nucleic acid binding transcription factor activity
relationship: has_part GO:0001068 ! transcription regulatory region RNA binding
created_by: kchris
creation_date: 2010-10-21T04:19:17Z

[Term]
id: GO:0001071
name: nucleic acid binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_yeast
subset: high_level_annotation_qc
synonym: "transcription factor activity" BROAD []
is_a: GO:0003674 ! molecular_function
relationship: has_part GO:0003676 ! nucleic acid binding
relationship: part_of GO:2001141 ! regulation of RNA biosynthetic process
created_by: kchris
creation_date: 2010-10-21T04:37:54Z

[Term]
id: GO:0001072
name: RNA binding transcription antitermination factor activity
namespace: molecular_function
def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211]
subset: gosubset_prok
is_a: GO:0001070 ! RNA binding transcription factor activity
relationship: part_of GO:0031564 ! transcription antitermination
created_by: kchris
creation_date: 2010-10-21T04:48:17Z

[Term]
id: GO:0001073
name: DNA binding transcription antitermination factor activity
namespace: molecular_function
def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211]
subset: gosubset_prok
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0031564 ! transcription antitermination
created_by: kchris
creation_date: 2010-10-21T05:18:52Z

[Term]
id: GO:0001074
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-10-22T02:30:43Z

[Term]
id: GO:0001075
name: RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT []
is_a: GO:0000983 ! RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2010-10-22T02:35:51Z

[Term]
id: GO:0001076
name: RNA polymerase II transcription factor binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000989 ! transcription factor binding transcription factor activity
relationship: has_part GO:0001085 ! RNA polymerase II transcription factor binding
relationship: part_of GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-10-22T02:49:32Z

[Term]
id: GO:0001077
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
is_a: GO:0001228 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
created_by: kchris
creation_date: 2010-10-26T03:40:43Z

[Term]
id: GO:0001078
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
is_a: GO:0001227 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
created_by: kchris
creation_date: 2010-10-26T03:56:48Z

[Term]
id: GO:0001079
name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0090293 ! nitrogen catabolite regulation of transcription
created_by: kchris
creation_date: 2010-10-27T03:29:01Z

[Term]
id: GO:0001080
name: nitrogen catabolite activation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090294 ! nitrogen catabolite activation of transcription
created_by: kchris
creation_date: 2010-10-27T03:32:34Z

[Term]
id: GO:0001081
name: nitrogen catabolite repression of transcription from RNA polymerase II promoter
namespace: biological_process
def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072]
synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah]
is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a: GO:0090295 ! nitrogen catabolite repression of transcription
created_by: kchris
creation_date: 2010-10-27T03:38:05Z

[Term]
id: GO:0001082
name: RNA polymerase I transcription factor binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000989 ! transcription factor binding transcription factor activity
relationship: has_part GO:0001179 ! RNA polymerase I transcription factor binding
relationship: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2010-10-27T04:03:47Z

[Term]
id: GO:0001083
name: RNA polymerase II basal transcription factor binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity
relationship: has_part GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-27T04:12:55Z

[Term]
id: GO:0001084
name: TFIID-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001094 ! TFIID-class transcription factor binding
created_by: kchris
creation_date: 2010-10-27T04:15:22Z

[Term]
id: GO:0001085
name: RNA polymerase II transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:08:59Z

[Term]
id: GO:0001086
name: TFIIA-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001092 ! TFIIA-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:14:59Z

[Term]
id: GO:0001087
name: TFIIB-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001093 ! TFIIB-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:18:00Z

[Term]
id: GO:0001088
name: TFIIE-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001095 ! TFIIE-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:25:22Z

[Term]
id: GO:0001089
name: TFIIF-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001096 ! TFIIF-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:27:12Z

[Term]
id: GO:0001090
name: TFIIH-class binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH]
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0001097 ! TFIIH-class transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:28:01Z

[Term]
id: GO:0001091
name: RNA polymerase II basal transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding
created_by: kchris
creation_date: 2010-10-28T02:30:02Z

[Term]
id: GO:0001092
name: TFIIA-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:37:19Z

[Term]
id: GO:0001093
name: TFIIB-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:46:15Z

[Term]
id: GO:0001094
name: TFIID-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:48:33Z

[Term]
id: GO:0001095
name: TFIIE-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:49:20Z

[Term]
id: GO:0001096
name: TFIIF-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:51:20Z

[Term]
id: GO:0001097
name: TFIIH-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867]
is_a: GO:0001091 ! RNA polymerase II basal transcription factor binding
created_by: kchris
creation_date: 2010-10-28T02:51:41Z

[Term]
id: GO:0001098
name: basal transcription machinery binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
is_a: GO:0005515 ! protein binding
created_by: kchris
creation_date: 2010-11-24T12:50:49Z

[Term]
id: GO:0001099
name: basal RNA polymerase II transcription machinery binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH]
comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors.
is_a: GO:0001098 ! basal transcription machinery binding
created_by: kchris
creation_date: 2010-11-24T12:54:33Z

[Term]
id: GO:0001100
name: negative regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
synonym: "down regulation of exit from mitosis" EXACT []
synonym: "down-regulation of exit from mitosis" EXACT []
synonym: "downregulation of exit from mitosis" EXACT []
synonym: "inhibition of exit from mitosis" NARROW []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0010948 ! negative regulation of cell cycle process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0010458 ! exit from mitosis
relationship: negatively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0001101
name: response to acid
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn]
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0001102
name: RNA polymerase II activating transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0033613 ! activating transcription factor binding
created_by: kchris
creation_date: 2010-11-24T02:17:08Z

[Term]
id: GO:0001103
name: RNA polymerase II repressing transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH]
is_a: GO:0001085 ! RNA polymerase II transcription factor binding
is_a: GO:0070491 ! repressing transcription factor binding
created_by: kchris
creation_date: 2010-11-24T02:34:55Z

[Term]
id: GO:0001104
name: RNA polymerase II transcription cofactor activity
namespace: molecular_function
alt_id: GO:0016455
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "RNA polymerase II transcription mediator activity" RELATED []
synonym: "RNA polymerase II transcriptional co-regulator" EXACT []
synonym: "RNA polymerase II transcriptional cofactor activity" EXACT []
synonym: "thyroid receptor-associated protein" RELATED []
synonym: "TRAP protein" RELATED []
is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0001099 ! basal RNA polymerase II transcription machinery binding
created_by: kchris
creation_date: 2010-11-24T03:02:15Z

[Term]
id: GO:0001105
name: RNA polymerase II transcription coactivator activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
subset: gosubset_prok
synonym: "RNA polymerase II transcription co-activator activity" EXACT []
is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity
is_a: GO:0001190 ! RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
is_a: GO:0003713 ! transcription coactivator activity
relationship: has_part GO:0001102 ! RNA polymerase II activating transcription factor binding
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-11-24T03:08:19Z

[Term]
id: GO:0001106
name: RNA polymerase II transcription corepressor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
synonym: "RNA polymerase II transcription co-repressor activity" EXACT []
is_a: GO:0001104 ! RNA polymerase II transcription cofactor activity
is_a: GO:0001191 ! RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
is_a: GO:0003714 ! transcription corepressor activity
relationship: has_part GO:0001103 ! RNA polymerase II repressing transcription factor binding
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-11-24T03:14:44Z

[Term]
id: GO:0001108
name: bacterial-type RNA polymerase holo enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH]
subset: gosubset_prok
synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT []
is_a: GO:0001098 ! basal transcription machinery binding
created_by: kchris
creation_date: 2010-11-30T04:26:04Z

[Term]
id: GO:0001109
name: promoter clearance during DNA-dependent transcription
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "promoter escape" BROAD []
is_a: GO:0032774 ! RNA biosynthetic process
relationship: has_part GO:0001119 ! protein-DNA-RNA complex remodeling
relationship: part_of GO:0006351 ! transcription, DNA-dependent
created_by: kchris
creation_date: 2010-12-01T02:13:09Z

[Term]
id: GO:0001110
name: promoter clearance from RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH]
is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter
created_by: kchris
creation_date: 2010-12-01T03:08:29Z

[Term]
id: GO:0001111
name: promoter clearance from RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047]
synonym: "promoter escape from RNA polymerase II promoter" EXACT []
is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-12-01T03:09:31Z

[Term]
id: GO:0001112
name: DNA-dependent transcriptional open complex formation
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "promoter melting" BROAD []
is_a: GO:0001120 ! protein-DNA complex remodeling
relationship: part_of GO:0006352 ! transcription initiation, DNA-dependent
created_by: kchris
creation_date: 2010-12-02T02:15:04Z

[Term]
id: GO:0001113
name: transcriptional open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161]
synonym: "RNA polymerase II promoter melting" EXACT []
is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter
created_by: kchris
creation_date: 2010-12-02T02:27:19Z

[Term]
id: GO:0001114
name: protein-DNA-RNA complex
namespace: cellular_component
def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH]
is_a: GO:0032991 ! macromolecular complex
created_by: kchris
creation_date: 2010-12-03T02:09:38Z

[Term]
id: GO:0001115
name: protein-DNA-RNA complex subunit organization
namespace: biological_process
def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH]
synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah]
is_a: GO:0043933 ! macromolecular complex subunit organization
created_by: kchris
creation_date: 2010-12-03T04:00:02Z

[Term]
id: GO:0001116
name: protein-DNA-RNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0034622 ! cellular macromolecular complex assembly
created_by: kchris
creation_date: 2010-12-03T04:01:38Z

[Term]
id: GO:0001117
name: protein-DNA-RNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0034623 ! cellular macromolecular complex disassembly
created_by: kchris
creation_date: 2010-12-03T04:04:07Z

[Term]
id: GO:0001118
name: transcription ternary complex disassembly
namespace: biological_process
def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH]
synonym: "transcription protein-DNA-RNA complex disassembly" EXACT []
is_a: GO:0001117 ! protein-DNA-RNA complex disassembly
relationship: part_of GO:0006353 ! transcription termination, DNA-dependent
created_by: kchris
creation_date: 2010-12-03T04:11:34Z

[Term]
id: GO:0001119
name: protein-DNA-RNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH]
is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization
is_a: GO:0034367 ! macromolecular complex remodeling
created_by: kchris
creation_date: 2010-12-03T04:15:52Z

[Term]
id: GO:0001120
name: protein-DNA complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:txnOH]
is_a: GO:0034367 ! macromolecular complex remodeling
is_a: GO:0071824 ! protein-DNA complex subunit organization
created_by: kchris
creation_date: 2010-12-03T04:17:15Z

[Term]
id: GO:0001121
name: transcription from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH]
is_a: GO:0006351 ! transcription, DNA-dependent
created_by: kchris
creation_date: 2010-12-06T03:32:13Z

[Term]
id: GO:0001122
name: promoter clearance from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161]
is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:38:10Z

[Term]
id: GO:0001123
name: transcription initiation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161]
is_a: GO:0006352 ! transcription initiation, DNA-dependent
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:40:12Z

[Term]
id: GO:0001124
name: transcription elongation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT []
is_a: GO:0006354 ! transcription elongation, DNA-dependent
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:46:27Z

[Term]
id: GO:0001125
name: transcription termination from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161]
is_a: GO:0006353 ! transcription termination, DNA-dependent
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:47:43Z

[Term]
id: GO:0001126
name: bacterial-type RNA polymerase preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:18280161]
synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT []
synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT []
synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT []
is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T03:54:45Z

[Term]
id: GO:0001127
name: transcriptional open complex formation at bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161]
is_a: GO:0001112 ! DNA-dependent transcriptional open complex formation
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2010-12-06T04:04:16Z

[Term]
id: GO:0001128
name: RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867]
comment: Note that some basal transcription factors are themselves considered to have coactivator activity, in that they mediate interactions between an activator and either RNA polymerase II itself or another basal transcription factor.
is_a: GO:0001105 ! RNA polymerase II transcription coactivator activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T02:13:36Z

[Term]
id: GO:0001129
name: TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
comment: For example, both TFIIA as well as TFIIB interact with TBP bound to DNA to stabilize formation of the preinitiation complex.
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW []
is_a: GO:0001132 ! TBP-class protein binding RNA polymerase II transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T02:53:35Z

[Term]
id: GO:0001130
name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: has_part GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
relationship: part_of GO:0001121 ! transcription from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2011-01-26T10:36:02Z

[Term]
id: GO:0001131
name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
relationship: has_part GO:0000986 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-26T10:50:37Z

[Term]
id: GO:0001132
name: TBP-class protein binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867]
synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW []
synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW []
is_a: GO:0001083 ! RNA polymerase II basal transcription factor binding transcription factor activity
relationship: has_part GO:0017025 ! TBP-class protein binding
created_by: kchris
creation_date: 2011-01-20T04:15:44Z

[Term]
id: GO:0001133
name: sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity
created_by: kchris
creation_date: 2011-01-20T04:40:20Z

[Term]
id: GO:0001134
name: transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:16858867]
is_a: GO:0000989 ! transcription factor binding transcription factor activity
created_by: kchris
creation_date: 2011-01-20T04:57:59Z

[Term]
id: GO:0001135
name: RNA polymerase II transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity
is_a: GO:0001134 ! transcription factor recruiting transcription factor activity
created_by: kchris
creation_date: 2011-01-20T05:13:12Z

[Term]
id: GO:0001136
name: TFIIE-class transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
is_a: GO:0001088 ! TFIIE-class binding transcription factor activity
is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:24:07Z

[Term]
id: GO:0001137
name: TFIIF-class transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
is_a: GO:0001089 ! TFIIF-class binding transcription factor activity
is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:35:02Z

[Term]
id: GO:0001138
name: TFIIH-class transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:16858867]
is_a: GO:0001090 ! TFIIH-class binding transcription factor activity
is_a: GO:0001135 ! RNA polymerase II transcription factor recruiting transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:39:10Z

[Term]
id: GO:0001139
name: core RNA polymerase II recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867]
is_a: GO:0000991 ! core RNA polymerase II binding transcription factor activity
relationship: part_of GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-20T05:55:01Z

[Term]
id: GO:0001140
name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:20491932, PMID:20629756]
is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
is_a: GO:0001216 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
created_by: kchris
creation_date: 2011-01-26T03:09:27Z

[Term]
id: GO:0001141
name: bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter." [GOC:txnOH, PMID:20491932, PMID:20629756]
is_a: GO:0001131 ! bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
is_a: GO:0001217 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
created_by: kchris
creation_date: 2011-01-26T03:15:45Z

[Term]
id: GO:0001142
name: sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: has_part GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter
created_by: kchris
creation_date: 2011-01-27T01:55:21Z

[Term]
id: GO:0001143
name: mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
relationship: has_part GO:0000997 ! mitochondrial RNA polymerase core promoter sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:08:44Z

[Term]
id: GO:0001144
name: mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH, PMID:18391175]
is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
relationship: has_part GO:0001045 ! mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:11:59Z

[Term]
id: GO:0001145
name: mitochondrial RNA polymerase termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175]
is_a: GO:0001044 ! mitochondrial RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T02:34:53Z

[Term]
id: GO:0001146
name: mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase." [GOC:txnOH, PMID:18391175]
is_a: GO:0001142 ! sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity
relationship: has_part GO:0001145 ! mitochondrial RNA polymerase termination site sequence-specific DNA binding
relationship: part_of GO:0006393 ! termination of mitochondrial transcription
created_by: kchris
creation_date: 2011-01-27T02:42:23Z

[Term]
id: GO:0001147
name: transcription termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175]
comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation.
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0001160 ! transcription termination site DNA binding
created_by: kchris
creation_date: 2011-01-27T02:48:26Z

[Term]
id: GO:0001148
name: bacterial-type RNA polymerase termination site sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:04:07Z

[Term]
id: GO:0001149
name: bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161]
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
relationship: has_part GO:0001148 ! bacterial-type RNA polymerase termination site sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:08:41Z

[Term]
id: GO:0001150
name: bacterial-type RNA polymerase enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:11282468, PMID:20629756]
comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer".
synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" EXACT []
is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:42:53Z

[Term]
id: GO:0001151
name: bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:20629756]
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
relationship: has_part GO:0001150 ! bacterial-type RNA polymerase enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-27T03:47:54Z

[Term]
id: GO:0001152
name: RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "TFIIIA activity" RELATED []
synonym: "type 1 RNA polymerase III promoter recognition" EXACT []
is_a: GO:0001010 ! sequence-specific DNA binding transcription factor recruiting transcription factor activity
is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity
relationship: has_part GO:0001002 ! RNA polymerase III type 1 promoter sequence-specific DNA binding
relationship: has_part GO:0001156 ! TFIIIC-class transcription factor binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-27T04:18:21Z

[Term]
id: GO:0001153
name: RNA polymerase III transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH]
is_a: GO:0001007 ! RNA polymerase III transcription factor binding transcription factor activity
is_a: GO:0001134 ! transcription factor recruiting transcription factor activity
created_by: kchris
creation_date: 2011-01-27T04:45:37Z

[Term]
id: GO:0001154
name: TFIIIB-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T04:53:50Z

[Term]
id: GO:0001155
name: TFIIIA-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T04:57:49Z

[Term]
id: GO:0001156
name: TFIIIC-class transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659]
is_a: GO:0001025 ! RNA polymerase III transcription factor binding
created_by: kchris
creation_date: 2011-01-27T05:02:22Z

[Term]
id: GO:0001157
name: RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC." [GOC:txnOH, PMID:12381659]
comment: This represents TFIIIA.
synonym: "TFIIIC-type activity" RELATED []
is_a: GO:0001153 ! RNA polymerase III transcription factor recruiting transcription factor activity
relationship: has_part GO:0001154 ! TFIIIB-class transcription factor binding
relationship: has_part GO:0001155 ! TFIIIA-class transcription factor binding
relationship: part_of GO:0000999 ! RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly
created_by: kchris
creation_date: 2011-01-27T05:27:28Z

[Term]
id: GO:0001158
name: enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH]
is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding
is_a: GO:0035326 ! enhancer binding
created_by: kchris
creation_date: 2011-01-28T03:29:40Z

[Term]
id: GO:0001159
name: core promoter proximal region DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:37:52Z

[Term]
id: GO:0001160
name: transcription termination site DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH]
is_a: GO:0044212 ! transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:39:44Z

[Term]
id: GO:0001161
name: intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
is_a: GO:0044213 ! intronic transcription regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-28T03:44:02Z

[Term]
id: GO:0001162
name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH]
is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding
is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-28T03:46:19Z

[Term]
id: GO:0001163
name: RNA polymerase I regulatory region sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH]
is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding
created_by: kchris
creation_date: 2011-01-31T04:12:06Z

[Term]
id: GO:0001164
name: RNA polymerase I CORE element sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT []
synonym: "RNA polymerase I core promoter sequence-specific DNA binding" EXACT []
is_a: GO:0001046 ! core promoter sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T04:47:48Z

[Term]
id: GO:0001165
name: RNA polymerase I upstream control element sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED []
is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T05:09:10Z

[Term]
id: GO:0001166
name: RNA polymerase I enhancer sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
is_a: GO:0001158 ! enhancer sequence-specific DNA binding
is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding
created_by: kchris
creation_date: 2011-01-31T05:29:59Z

[Term]
id: GO:0001167
name: sequence-specific DNA binding RNA polymerase I transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH]
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0006356 ! regulation of transcription from RNA polymerase I promoter
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-02-03T04:07:46Z

[Term]
id: GO:0001168
name: RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity
relationship: has_part GO:0001165 ! RNA polymerase I upstream control element sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:23Z

[Term]
id: GO:0001169
name: RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT []
is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity
relationship: has_part GO:0001164 ! RNA polymerase I CORE element sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:42Z

[Term]
id: GO:0001170
name: RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832]
is_a: GO:0001167 ! sequence-specific DNA binding RNA polymerase I transcription factor activity
relationship: has_part GO:0001166 ! RNA polymerase I enhancer sequence-specific DNA binding
created_by: kchris
creation_date: 2011-02-03T04:10:59Z

[Term]
id: GO:0001171
name: reverse transcription
namespace: biological_process
def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252]
xref: Wikipedia:Reverse_transcription
is_a: GO:0006278 ! RNA-dependent DNA replication
created_by: kchris
creation_date: 2011-03-14T03:51:08Z

[Term]
id: GO:0001172
name: transcription, RNA-dependent
namespace: biological_process
def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH]
subset: gosubset_prok
is_a: GO:0032774 ! RNA biosynthetic process
created_by: kchris
creation_date: 2011-03-14T03:54:46Z

[Term]
id: GO:0001173
name: DNA-dependent transcriptional start site selection
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006352 ! transcription initiation, DNA-dependent
created_by: kchris
creation_date: 2011-06-20T12:44:11Z

[Term]
id: GO:0001174
name: transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104]
is_a: GO:0001173 ! DNA-dependent transcriptional start site selection
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T01:35:28Z

[Term]
id: GO:0001175
name: transcriptional start site selection at RNA polymerase III promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0001173 ! DNA-dependent transcriptional start site selection
relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter
created_by: kchris
creation_date: 2011-06-20T01:47:38Z

[Term]
id: GO:0001176
name: transcriptional start site selection at bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0001173 ! DNA-dependent transcriptional start site selection
relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2011-06-20T01:48:56Z

[Term]
id: GO:0001177
name: regulation of transcriptional open complex formation at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH]
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter
relationship: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T02:01:18Z

[Term]
id: GO:0001178
name: regulation of transcriptional start site selection at RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH]
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter
relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter
created_by: kchris
creation_date: 2011-06-20T02:06:00Z

[Term]
id: GO:0001179
name: RNA polymerase I transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2011-08-12T03:03:03Z

[Term]
id: GO:0001180
name: transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript, resulting in the subsequent synthesis of rRNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:txnOH]
is_a: GO:0006361 ! transcription initiation from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:45:49Z

[Term]
id: GO:0001181
name: core RNA polymerase I binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase I (RNAP I) complex, typically composed of fourteen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0000990 ! core RNA polymerase binding transcription factor activity
relationship: has_part GO:0001042 ! RNA polymerase I core binding
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-12T04:13:30Z

[Term]
id: GO:0001182
name: promoter clearance from RNA polymerase I promoter
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH]
is_a: GO:0001109 ! promoter clearance during DNA-dependent transcription
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:49:28Z

[Term]
id: GO:0001183
name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH]
is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T03:57:25Z

[Term]
id: GO:0001184
name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript
namespace: biological_process
def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH]
is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T04:03:52Z

[Term]
id: GO:0001185
name: termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript
namespace: biological_process
def: "The process in which the synthesis of an rRNA molecule from a promoter for the nuclear large ribosomal RNA (rRNA) transcript by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:txnOH]
is_a: GO:0006363 ! termination of RNA polymerase I transcription
relationship: part_of GO:0042790 ! transcription of nuclear large rRNA transcript from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-15T04:07:43Z

[Term]
id: GO:0001186
name: RNA polymerase I transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0001082 ! RNA polymerase I transcription factor binding transcription factor activity
is_a: GO:0001134 ! transcription factor recruiting transcription factor activity
created_by: kchris
creation_date: 2011-08-24T04:00:18Z

[Term]
id: GO:0001187
name: RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0001169 ! RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity
is_a: GO:0001186 ! RNA polymerase I transcription factor recruiting transcription factor activity
relationship: part_of GO:0001189 ! RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
created_by: kchris
creation_date: 2011-08-24T04:07:50Z

[Term]
id: GO:0001188
name: RNA polymerase I transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0070897 ! DNA-dependent transcriptional preinitiation complex assembly
relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter
created_by: kchris
creation_date: 2011-08-24T04:16:28Z

[Term]
id: GO:0001189
name: RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832]
is_a: GO:0001188 ! RNA polymerase I transcriptional preinitiation complex assembly
relationship: part_of GO:0001180 ! transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript
created_by: kchris
creation_date: 2011-08-24T04:20:43Z

[Term]
id: GO:0001190
name: RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH]
is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-08-25T02:07:14Z

[Term]
id: GO:0001191
name: RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836]
is_a: GO:0001076 ! RNA polymerase II transcription factor binding transcription factor activity
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-08-25T02:12:30Z

[Term]
id: GO:0001192
name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH]
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006354 ! transcription elongation, DNA-dependent
created_by: kchris
creation_date: 2011-09-02T02:25:30Z

[Term]
id: GO:0001193
name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation
relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter
created_by: kchris
creation_date: 2011-09-02T02:31:00Z

[Term]
id: GO:0001194
name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter." [GOC:txnOH]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation
relationship: part_of GO:0001124 ! transcription elongation from bacterial-type RNA polymerase promoter
created_by: kchris
creation_date: 2011-09-02T02:37:59Z

[Term]
id: GO:0001195
name: maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter
namespace: biological_process
def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH]
is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-dependent transcription elongation
relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter
created_by: kchris
creation_date: 2011-09-02T02:41:29Z

[Term]
id: GO:0001196
name: regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-dependent
created_by: kchris
creation_date: 2011-11-23T09:25:32Z

[Term]
id: GO:0001197
name: positive regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW []
synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT []
is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter
is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-dependent
created_by: kchris
creation_date: 2011-11-23T09:31:33Z

[Term]
id: GO:0001198
name: negative regulation of mating-type specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT []
synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW []
is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter
is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-dependent
created_by: kchris
creation_date: 2011-11-23T09:36:06Z

[Term]
id: GO:0001199
name: metal ion regulated sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0003700 ! sequence-specific DNA binding transcription factor activity
relationship: has_part GO:0046872 ! metal ion binding
relationship: part_of GO:0071248 ! cellular response to metal ion
created_by: kchris
creation_date: 2011-11-23T10:52:49Z

[Term]
id: GO:0001200
name: metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2011-11-23T11:18:49Z

[Term]
id: GO:0001201
name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor that binds the core promoter proximal region in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0000982 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
is_a: GO:0001200 ! metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
created_by: kchris
creation_date: 2011-11-23T11:22:42Z

[Term]
id: GO:0001202
name: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0005507 ! copper ion binding
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: kchris
creation_date: 2011-11-23T11:27:57Z

[Term]
id: GO:0001203
name: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), in such a way that zinc ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II." [GOC:txnOH, PMID:22084422]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0008270 ! zinc ion binding
relationship: part_of GO:0071294 ! cellular response to zinc ion
created_by: kchris
creation_date: 2011-11-23T11:36:25Z

[Term]
id: GO:0001204
name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2011-11-23T12:07:06Z

[Term]
id: GO:0001205
name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" EXACT []
is_a: GO:0001228 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
is_a: GO:0003705 ! RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2012-01-26T03:10:20Z

[Term]
id: GO:0001206
name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH]
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" EXACT []
is_a: GO:0001227 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
is_a: GO:0003705 ! RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
created_by: kchris
creation_date: 2012-01-26T03:10:40Z

[Term]
id: GO:0001207
name: histone displacement
namespace: biological_process
def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
is_a: GO:0034728 ! nucleosome organization
created_by: karen
creation_date: 2012-03-27T10:56:56Z

[Term]
id: GO:0001208
name: histone H2A-H2B dimer displacement
namespace: biological_process
def: "The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128]
is_a: GO:0001207 ! histone displacement
created_by: karen
creation_date: 2012-03-27T11:03:40Z

[Term]
id: GO:0001209
name: metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-dependent
created_by: kchris
creation_date: 2012-04-04T02:26:42Z

[Term]
id: GO:0001210
name: metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001199 ! metal ion regulated sequence-specific DNA binding transcription factor activity
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-dependent
created_by: kchris
creation_date: 2012-04-04T02:53:25Z

[Term]
id: GO:0001211
name: copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001202 ! copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
is_a: GO:0001213 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
created_by: kchris
creation_date: 2012-04-04T03:03:00Z

[Term]
id: GO:0001212
name: zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001203 ! zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
is_a: GO:0001213 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
created_by: kchris
creation_date: 2012-04-04T03:13:34Z

[Term]
id: GO:0001213
name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001077 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
created_by: kchris
creation_date: 2012-04-04T03:18:43Z

[Term]
id: GO:0001214
name: metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH, PMID:22084422, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001078 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
is_a: GO:0001201 ! metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
created_by: kchris
creation_date: 2012-04-04T03:33:08Z

[Term]
id: GO:0001215
name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001204 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
is_a: GO:0001209 ! metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
created_by: kchris
creation_date: 2012-04-04T03:47:42Z

[Term]
id: GO:0001216
name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc]
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
relationship: part_of GO:0045893 ! positive regulation of transcription, DNA-dependent
created_by: kchris
creation_date: 2012-04-04T03:55:59Z

[Term]
id: GO:0001217
name: sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:krc]
is_a: GO:0001130 ! sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-dependent
created_by: kchris
creation_date: 2012-04-04T03:57:16Z

[Term]
id: GO:0001218
name: metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist." [GOC:txnOH, PMID:12829264, PMID:12829265, PMID:2674688]
comment: This term is intended for sequence specific DNA binding transcription factors whose transcription factor activity is regulated by binding of a metal ion, e.g. copper, zinc, etc. Do not use this term for transcription factors which bind a metal ion all the time, where binding of that metal ion does not regulate the DNA binding, or some other activity, required for the gene product to act as a transcription factor.
is_a: GO:0001204 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
is_a: GO:0001210 ! metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
created_by: kchris
creation_date: 2012-04-05T10:46:50Z

[Term]
id: GO:0001219
name: copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), in such a way that copper ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19928961]
synonym: "copper ion sensor" RELATED []
is_a: GO:0001218 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
relationship: has_part GO:0005507 ! copper ion binding
relationship: part_of GO:0071280 ! cellular response to copper ion
created_by: kchris
creation_date: 2012-04-05T11:13:34Z

[Term]
id: GO:0001220
name: cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with cadmium (Cd) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd), in such a way that cadmium (Cd) ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase." [GOC:krc, PMID:12829264, PMID:12829265, PMID:19456862]
synonym: "cadmium ion sensor" RELATED []
is_a: GO:0001218 ! metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription
relationship: has_part GO:0046870 ! cadmium ion binding
relationship: part_of GO:0071276 ! cellular response to cadmium ion
created_by: kchris
creation_date: 2012-04-05T11:46:06Z

[Term]
id: GO:0001221
name: transcription cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors  do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0008134 ! transcription factor binding
created_by: kchris
creation_date: 2012-04-16T03:19:05Z

[Term]
id: GO:0001222
name: transcription corepressor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:27:26Z

[Term]
id: GO:0001223
name: transcription coactivator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors  and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:30:16Z

[Term]
id: GO:0001224
name: RNA polymerase II transcription cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors  do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001221 ! transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:37:06Z

[Term]
id: GO:0001225
name: RNA polymerase II transcription coactivator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II  transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors  and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001223 ! transcription coactivator binding
is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:39:41Z

[Term]
id: GO:0001226
name: RNA polymerase II transcription corepressor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc]
is_a: GO:0001222 ! transcription corepressor binding
is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding
created_by: kchris
creation_date: 2012-04-16T03:39:47Z

[Term]
id: GO:0001227
name: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: part_of GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2012-04-16T04:41:29Z

[Term]
id: GO:0001228
name: RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter." [GOC:krc]
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: part_of GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
created_by: kchris
creation_date: 2012-04-16T04:44:21Z

[Term]
id: GO:0001300
name: chronological cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934]
synonym: "chronological cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001301
name: progressive alteration of chromatin involved in cell aging
namespace: biological_process
def: "The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938]
synonym: "age-dependent accumulation of genetic damage" RELATED []
synonym: "progressive alteration of chromatin during cell ageing" EXACT []
synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0016568 ! chromatin modification
intersection_of: GO:0016568 ! chromatin modification
intersection_of: part_of GO:0007569 ! cell aging
relationship: part_of GO:0007569 ! cell aging

[Term]
id: GO:0001302
name: replicative cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934]
synonym: "replicative cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001303
name: nucleolar fragmentation involved in replicative aging
namespace: biological_process
def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807]
synonym: "nucleolar fragmentation during replicative ageing" RELATED []
synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007576 ! nucleolar fragmentation
intersection_of: GO:0007576 ! nucleolar fragmentation
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001304
name: progressive alteration of chromatin involved in replicative cell aging
namespace: biological_process
def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb]
synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT []
synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001305
name: progressive alteration of chromatin involved in chronological cell aging
namespace: biological_process
def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb]
synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED []
synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: GO:0001301 ! progressive alteration of chromatin involved in cell aging
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001306
name: age-dependent response to oxidative stress
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
is_a: GO:0006979 ! response to oxidative stress
relationship: part_of GO:0007571 ! age-dependent general metabolic decline

[Term]
id: GO:0001307
name: extrachromosomal circular DNA accumulation involved in replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh]
synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging
is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging

[Term]
id: GO:0001308
name: negative regulation of chromatin silencing involved in replicative cell aging
namespace: biological_process
def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934]
synonym: "loss of chromatin silencing during replicative cell ageing" RELATED []
synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT []
is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging
is_a: GO:0031936 ! negative regulation of chromatin silencing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006342 ! chromatin silencing
intersection_of: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001309
name: age-dependent telomere shortening
namespace: biological_process
def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807]
is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging
is_a: GO:0010834 ! telomere maintenance via telomere shortening

[Term]
id: GO:0001310
name: extrachromosomal rDNA circle accumulation involved in replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED []
synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED []
is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001311
name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934]
synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED []
is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging

[Term]
id: GO:0001312
name: replication of extrachromosomal rDNA circles involved in replicative cell aging
namespace: biological_process
def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED []
synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED []
is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging

[Term]
id: GO:0001313
name: formation of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh]
synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT []
synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED []
synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001325 ! formation of extrachromosomal circular DNA
intersection_of: GO:0001325 ! formation of extrachromosomal circular DNA
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001314
name: replication of extrachromosomal circular DNA involved in replicative cell aging
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT []
synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001326 ! replication of extrachromosomal circular DNA
intersection_of: GO:0001326 ! replication of extrachromosomal circular DNA
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging

[Term]
id: GO:0001315
name: age-dependent response to reactive oxygen species
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
subset: gosubset_prok
synonym: "age-dependent response to active oxygen species" EXACT []
synonym: "age-dependent response to AOS" EXACT []
synonym: "age-dependent response to reactive oxidative species" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate" EXACT []
synonym: "age-dependent response to ROI" EXACT []
synonym: "age-dependent response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0001306 ! age-dependent response to oxidative stress

[Term]
id: GO:0001316
name: age-dependent response to reactive oxygen species involved in replicative cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED []
synonym: "age-dependent response to AOS during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT []
synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during replicative cell aging" RELATED []
synonym: "age-dependent response to ROS during replicative cell aging" RELATED []
is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging
is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species
intersection_of: GO:0001315 ! age-dependent response to reactive oxygen species
intersection_of: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001317
name: accumulation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging

[Term]
id: GO:0001318
name: formation of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006464 ! cellular protein modification process
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging

[Term]
id: GO:0001319
name: inheritance of oxidatively modified proteins involved in replicative cell aging
namespace: biological_process
def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh]
synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED []
synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008105 ! asymmetric protein localization
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging

[Term]
id: GO:0001320
name: age-dependent response to reactive oxygen species involved in chronological cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED []
synonym: "age-dependent response to AOS during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED []
synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb]
synonym: "age-dependent response to ROI during chronological cell aging" RELATED []
synonym: "age-dependent response to ROS during chronological cell aging" RELATED []
is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging
is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species
intersection_of: GO:0001315 ! age-dependent response to reactive oxygen species
intersection_of: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001321
name: age-dependent general metabolic decline involved in replicative cell aging
namespace: biological_process
def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED []
synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007571 ! age-dependent general metabolic decline
intersection_of: GO:0007571 ! age-dependent general metabolic decline
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001322
name: age-dependent response to oxidative stress involved in replicative cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001306 ! age-dependent response to oxidative stress
is_a: GO:0034599 ! cellular response to oxidative stress
intersection_of: GO:0001306 ! age-dependent response to oxidative stress
intersection_of: part_of GO:0001302 ! replicative cell aging
relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging

[Term]
id: GO:0001323
name: age-dependent general metabolic decline involved in chronological cell aging
namespace: biological_process
def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah]
synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED []
synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007571 ! age-dependent general metabolic decline
intersection_of: GO:0007571 ! age-dependent general metabolic decline
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001324
name: age-dependent response to oxidative stress involved in chronological cell aging
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED []
synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001306 ! age-dependent response to oxidative stress
is_a: GO:0034599 ! cellular response to oxidative stress
intersection_of: GO:0001306 ! age-dependent response to oxidative stress
intersection_of: part_of GO:0001300 ! chronological cell aging
relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging

[Term]
id: GO:0001325
name: formation of extrachromosomal circular DNA
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938]
subset: gosubset_prok
synonym: "assembly of extrachromosomal circular DNA" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0071844 ! cellular component assembly at cellular level

[Term]
id: GO:0001326
name: replication of extrachromosomal circular DNA
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0001400
name: mating projection base
namespace: cellular_component
def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc]
synonym: "base of shmoo tip" NARROW []
synonym: "conjugation tube base" NARROW []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0001401
name: mitochondrial sorting and assembly machinery complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
synonym: "SAM complex" EXACT []
synonym: "TOB complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0001402
name: signal transduction involved in filamentous growth
namespace: biological_process
def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395]
synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED []
synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
intersection_of: GO:0007165 ! signal transduction
intersection_of: part_of GO:0030447 ! filamentous growth
relationship: part_of GO:0030447 ! filamentous growth

[Term]
id: GO:0001403
name: invasive growth in response to glucose limitation
namespace: biological_process
def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395]
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'invasive growth', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.
subset: goslim_yeast
synonym: "colony morphology" RELATED []
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0001404
name: invasive growth
namespace: biological_process
def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "tissue invasion" EXACT []
is_obsolete: true
consider: GO:0044409

[Term]
id: GO:0001405
name: presequence translocase-associated import motor
namespace: cellular_component
def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855]
synonym: "mitochondrial import motor" EXACT []
synonym: "PAM complex" EXACT []
synonym: "pre-sequence translocase-associated import motor" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex

[Term]
id: GO:0001406
name: glycerophosphodiester transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
relationship: part_of GO:0001407 ! glycerophosphodiester transport

[Term]
id: GO:0001407
name: glycerophosphodiester transport
namespace: biological_process
def: "The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0001408
name: guanine nucleotide transport
namespace: biological_process
def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0001409
name: guanine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity
relationship: part_of GO:0001408 ! guanine nucleotide transport

[Term]
id: GO:0001410
name: chlamydospore formation
namespace: biological_process
alt_id: GO:0055027
def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094]
synonym: "chlamydospore development" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development

[Term]
id: GO:0001502
name: cartilage condensation
namespace: biological_process
def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649]
comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'.
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001504
name: neurotransmitter uptake
namespace: biological_process
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387]
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
synonym: "neurotransmitter reuptake" EXACT []
xref: Reactome:REACT_106095 "Neurotransmitter uptake and Metabolism In Glial Cells, Gallus gallus"
xref: Reactome:REACT_106673 "Neurotransmitter uptake and Metabolism In Glial Cells, Bos taurus"
xref: Reactome:REACT_107830 "Neurotransmitter uptake and Metabolism In Glial Cells, Arabidopsis thaliana"
xref: Reactome:REACT_114027 "Neurotransmitter uptake and Metabolism In Glial Cells, Staphylococcus aureus N315"
xref: Reactome:REACT_13594 "Neurotransmitter uptake and Metabolism In Glial Cells, Homo sapiens"
xref: Reactome:REACT_29399 "Neurotransmitter uptake and Metabolism In Glial Cells, Drosophila melanogaster"
xref: Reactome:REACT_30311 "Neurotransmitter uptake and Metabolism In Glial Cells, Rattus norvegicus"
xref: Reactome:REACT_82534 "Neurotransmitter uptake and Metabolism In Glial Cells, Caenorhabditis elegans"
xref: Reactome:REACT_88126 "Neurotransmitter uptake and Metabolism In Glial Cells, Escherichia coli"
xref: Reactome:REACT_89424 "Neurotransmitter uptake and Metabolism In Glial Cells, Sus scrofa"
xref: Reactome:REACT_92363 "Neurotransmitter uptake and Metabolism In Glial Cells, Canis familiaris"
xref: Reactome:REACT_93291 "Neurotransmitter uptake and Metabolism In Glial Cells, Taeniopygia guttata"
xref: Reactome:REACT_94616 "Neurotransmitter uptake and Metabolism In Glial Cells, Schizosaccharomyces pombe"
xref: Reactome:REACT_97761 "Neurotransmitter uptake and Metabolism In Glial Cells, Saccharomyces cerevisiae"
xref: Reactome:REACT_98224 "Neurotransmitter uptake and Metabolism In Glial Cells, Oryza sativa"
xref: Reactome:REACT_98482 "Neurotransmitter uptake and Metabolism In Glial Cells, Xenopus tropicalis"
xref: Reactome:REACT_98978 "Neurotransmitter uptake and Metabolism In Glial Cells, Danio rerio"
xref: Reactome:REACT_99735 "Neurotransmitter uptake and Metabolism In Glial Cells, Mus musculus"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0001505
name: regulation of neurotransmitter levels
namespace: biological_process
def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0001506
name: neurotransmitter biosynthetic process and storage
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387]
comment: This term was made obsolete because it is an amalgamation of its two children.
synonym: "neurotransmitter anabolism and storage" EXACT []
synonym: "neurotransmitter formation and storage" EXACT []
synonym: "neurotransmitter synthesis and storage" EXACT []
is_obsolete: true
consider: GO:0042136
consider: GO:0042137

[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
intersection_of: GO:0006581 ! acetylcholine catabolic process
intersection_of: occurs_in GO:0043083 ! synaptic cleft
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0001508
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0001509
name: legumain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "citvac" RELATED [EC:3.4.22.34]
synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34]
synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
xref: EC:3.4.22.34
xref: MetaCyc:3.4.22.34-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0001510
name: RNA methylation
namespace: biological_process
def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0009451 ! RNA modification
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0001511
name: fibrillin
namespace: molecular_function
def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0001527
consider: GO:0005509

[Term]
id: GO:0001512
name: dihydronicotinamide riboside quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2]
synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2]
synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2]
synonym: "NQO(2) activity" EXACT [EC:1.10.99.2]
synonym: "NQO2" RELATED [EC:1.10.99.2]
synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2]
synonym: "QR2 activity" RELATED [EC:1.10.99.2]
synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2]
synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT []
xref: EC:1.10.99.2
xref: MetaCyc:1.10.99.2-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0001514
name: selenocysteine incorporation
namespace: biological_process
def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]
subset: gosubset_prok
xref: RESID:AA0022
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0001515
name: opioid peptide activity
namespace: molecular_function
def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001516
name: prostaglandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]
subset: gosubset_prok
synonym: "prostaglandin anabolism" EXACT []
synonym: "prostaglandin biosynthesis" EXACT []
synonym: "prostaglandin formation" EXACT []
synonym: "prostaglandin synthesis" EXACT []
is_a: GO:0006693 ! prostaglandin metabolic process
is_a: GO:0046457 ! prostanoid biosynthetic process

[Term]
id: GO:0001517
name: N-acetylglucosamine 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd]
synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001518
name: voltage-gated sodium channel complex
namespace: cellular_component
def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732]
synonym: "voltage gated sodium channel complex" EXACT []
synonym: "voltage-dependent sodium channel complex" EXACT []
synonym: "voltage-sensitive sodium channel complex" EXACT []
xref: NIF_Subcellular:sao785001660
is_a: GO:0034706 ! sodium channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0001519
name: peptide amidation
namespace: biological_process
def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916]
subset: gosubset_prok
is_a: GO:0031179 ! peptide modification

[Term]
id: GO:0001520
name: outer dense fiber
namespace: cellular_component
def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820]
synonym: "outer dense fibre" EXACT []
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001522
name: pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
subset: gosubset_prok
synonym: "pseudouridylation" EXACT []
xref: Wikipedia:Pseudouridine
xref: Wikipedia:Pseudouridylation
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0001523
name: retinoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732]
subset: gosubset_prok
synonym: "retinoid metabolism" EXACT []
xref: Reactome:REACT_24968 "Vitamin A uptake in enterocytes, Homo sapiens"
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:0001524
name: globin
namespace: molecular_function
def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001526
name: proteoglycan sulfate transfer
namespace: biological_process
def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd]
comment: This term was made obsolete because it represents a group of molecular functions.
synonym: "proteoglycan sulphate transfer" EXACT []
is_obsolete: true
consider: GO:0006029
consider: GO:0006790
consider: GO:0050698

[Term]
id: GO:0001527
name: microfibril
namespace: cellular_component
def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235]
synonym: "extended fibrils" EXACT []
synonym: "fibrillin" RELATED []
is_a: GO:0043205 ! fibril

[Term]
id: GO:0001528
name: elastin
namespace: molecular_function
def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001529
name: elastin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001530
name: lipopolysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463]
synonym: "endotoxin binding" BROAD []
synonym: "LPS binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001531
name: interleukin-21 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai]
synonym: "IL-21" NARROW []
synonym: "interleukin-21 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0001532
name: interleukin-21 receptor activity
namespace: molecular_function
def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]
synonym: "IL-21 receptor activity" EXACT [GOC:mah]
synonym: "IL-21R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0019977 ! interleukin-21 binding
relationship: part_of GO:0038114 ! interleukin-21-mediated signaling pathway

[Term]
id: GO:0001533
name: cornified envelope
namespace: cellular_component
def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971]
subset: goslim_pir
xref: Wikipedia:Radial_spoke
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001535
name: radial spokehead
namespace: cellular_component
def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001536
name: radial spoke stalk
namespace: cellular_component
def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001537
name: N-acetylgalactosamine 4-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai]
synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001539
name: ciliary or flagellar motility
namespace: biological_process
def: "Cell motility due to movement of cilia or flagella." [GOC:hjd]
subset: gosubset_prok
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001540
name: beta-amyloid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001541
name: ovarian follicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "follicular phase" RELATED []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0001542
name: ovulation from ovarian follicle
namespace: biological_process
def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0030728 ! ovulation
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0001543
name: ovarian follicle rupture
namespace: biological_process
def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001542 ! ovulation from ovarian follicle

[Term]
id: GO:0001544
name: initiation of primordial ovarian follicle growth
namespace: biological_process
def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001545
name: primary ovarian follicle growth
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001546
name: preantral ovarian follicle growth
namespace: biological_process
def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0048162 ! multi-layer follicle stage

[Term]
id: GO:0001547
name: antral ovarian follicle growth
namespace: biological_process
def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001548
name: follicular fluid formation in ovarian follicle antrum
namespace: biological_process
def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu]
synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT []
synonym: "ovarian follicle antrum/follicular fluid formation" EXACT []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:0001549
name: cumulus cell differentiation
namespace: biological_process
def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu]
synonym: "ovarian cumulus cell differentiation" EXACT []
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0030154 ! cell differentiation
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001550
name: ovarian cumulus expansion
namespace: biological_process
def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu]
synonym: "ovarian cumulus growth" RELATED []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0001551
name: ovarian follicle endowment
namespace: biological_process
def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001552
name: ovarian follicle atresia
namespace: biological_process
def: "Ovarian follicle demise mediated by apoptosis." [http://ovary.stanford.edu]
is_a: GO:0006915 ! apoptotic process
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0001553
name: luteinization
namespace: biological_process
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0001554
name: luteolysis
namespace: biological_process
def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764]
xref: Wikipedia:Luteolysis
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0048469 ! cell maturation
is_a: GO:0048610 ! cellular process involved in reproduction
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001557
name: metabolic process resulting in cell growth
namespace: biological_process
def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph]
comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms.
is_obsolete: true
replaced_by: GO:0008152
replaced_by: GO:0016049

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators]
subset: gosubset_prok
xref: Reactome:REACT_6201 "DTOR is positively regulated by DRheb-GTP, Drosophila melanogaster"
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016049 ! cell growth
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001559
name: regulation of cell growth by detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT []
synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio
is_a: GO:0061387 ! regulation of extent of cell growth
intersection_of: GO:0016475 ! detection of nuclear:cytoplasmic ratio
intersection_of: results_in GO:0001558 ! regulation of cell growth

[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
namespace: biological_process
def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
intersection_of: GO:0001558 ! regulation of cell growth
intersection_of: part_of GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0001561
name: fatty acid alpha-oxidation
namespace: biological_process
def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html]
subset: gosubset_prok
xref: MetaCyc:PWY-2501
xref: Reactome:REACT_103076 "Alpha-oxidation of phytanate, Dictyostelium discoideum"
xref: Reactome:REACT_106518 "Alpha-oxidation of phytanate, Drosophila melanogaster"
xref: Reactome:REACT_106956 "Alpha-oxidation of phytanate, Mus musculus"
xref: Reactome:REACT_107335 "Alpha-oxidation of phytanate, Taeniopygia guttata"
xref: Reactome:REACT_109097 "Alpha-oxidation of phytanate, Saccharomyces cerevisiae"
xref: Reactome:REACT_17003 "Alpha-oxidation of phytanate, Homo sapiens"
xref: Reactome:REACT_29885 "Alpha-oxidation of phytanate, Oryza sativa"
xref: Reactome:REACT_47735 "Alpha-oxidation of phytanate, Gallus gallus"
xref: Reactome:REACT_78088 "Alpha-oxidation of phytanate, Bos taurus"
xref: Reactome:REACT_81097 "Alpha-oxidation of phytanate, Xenopus tropicalis"
xref: Reactome:REACT_83317 "Alpha-oxidation of phytanate, Caenorhabditis elegans"
xref: Reactome:REACT_87622 "Alpha-oxidation of phytanate, Sus scrofa"
xref: Reactome:REACT_87835 "Alpha-oxidation of phytanate, Arabidopsis thaliana"
xref: Reactome:REACT_90750 "Alpha-oxidation of phytanate, Canis familiaris"
xref: Reactome:REACT_92361 "Alpha-oxidation of phytanate, Mycobacterium tuberculosis"
xref: Reactome:REACT_94726 "Alpha-oxidation of phytanate, Escherichia coli"
xref: Reactome:REACT_94872 "Alpha-oxidation of phytanate, Rattus norvegicus"
xref: Reactome:REACT_96409 "Alpha-oxidation of phytanate, Danio rerio"
xref: Reactome:REACT_98637 "Alpha-oxidation of phytanate, Schizosaccharomyces pombe"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0001562
name: response to protozoan
namespace: biological_process
alt_id: GO:0042833
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai]
synonym: "resistance to pathogenic protozoa" RELATED []
synonym: "response to protozoa" EXACT []
synonym: "response to protozoon" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0001563
name: detection of protozoan
namespace: biological_process
def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of protozoa" EXACT []
synonym: "detection of protozoon" EXACT []
synonym: "perception of protozoa" RELATED []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0001564
name: resistance to pathogenic protozoa
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0001562

[Term]
id: GO:0001565
name: phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570]
is_a: GO:0038023 ! signaling receptor activity

[Term]
id: GO:0001566
name: non-kinase phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570]
is_a: GO:0001565 ! phorbol ester receptor activity

[Term]
id: GO:0001567
name: cholesterol 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21107]
synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38]
synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38]
xref: EC:1.14.99.38
xref: KEGG:R07218
xref: MetaCyc:1.14.99.38-RXN
xref: RHEA:21107
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001569
name: patterning of blood vessels
namespace: biological_process
def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0061138 ! morphogenesis of a branching epithelium
relationship: part_of GO:0001525 ! angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001571
name: non-tyrosine kinase fibroblast growth factor receptor activity
namespace: molecular_function
def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238]
synonym: "non-tyrosine kinase FGF receptor activity" EXACT []
synonym: "non-tyrosine kinase FGFR activity" EXACT []
is_a: GO:0004888 ! transmembrane signaling receptor activity

[Term]
id: GO:0001572
name: lactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501]
subset: gosubset_prok
synonym: "lactosylceramide anabolism" EXACT []
synonym: "lactosylceramide biosynthesis" EXACT []
synonym: "lactosylceramide formation" EXACT []
synonym: "lactosylceramide synthesis" EXACT []
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process

[Term]
id: GO:0001573
name: ganglioside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ganglioside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001574
name: ganglioside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732]
subset: gosubset_prok
synonym: "ganglioside anabolism" EXACT []
synonym: "ganglioside biosynthesis" EXACT []
synonym: "ganglioside formation" EXACT []
synonym: "ganglioside synthesis" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001575
name: globoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732]
subset: gosubset_prok
synonym: "globoside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001576
name: globoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732]
subset: gosubset_prok
synonym: "globoside anabolism" EXACT []
synonym: "globoside biosynthesis" EXACT []
synonym: "globoside formation" EXACT []
synonym: "globoside synthesis" EXACT []
is_a: GO:0001575 ! globoside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001577
name: galectin
namespace: molecular_function
def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "S-type lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0016936

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0001579
name: medium-chain fatty acid transport
namespace: biological_process
def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai]
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0001580
name: detection of chemical stimulus involved in sensory perception of bitter taste
namespace: biological_process
def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "bitter taste detection" EXACT []
synonym: "perception of bitter taste, detection of chemical stimulus" EXACT []
synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of bitter taste" EXACT []
synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT []
synonym: "sensory transduction of bitter taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050913 ! sensory perception of bitter taste
relationship: part_of GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:0001581
name: detection of chemical stimulus involved in sensory perception of sour taste
namespace: biological_process
def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sour taste, detection of chemical stimulus" EXACT []
synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory detection of sour taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory transduction of sour taste" EXACT []
synonym: "sour taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050915 ! sensory perception of sour taste
relationship: part_of GO:0050915 ! sensory perception of sour taste

[Term]
id: GO:0001582
name: detection of chemical stimulus involved in sensory perception of sweet taste
namespace: biological_process
def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sweet taste, detection of chemical stimulus" EXACT []
synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory detection of sweet taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory transduction of sweet taste" EXACT []
synonym: "sweet taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050916 ! sensory perception of sweet taste
relationship: part_of GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:0001583
name: detection of chemical stimulus involved in sensory perception of salty taste
namespace: biological_process
def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of salty taste, detection of chemical stimulus" EXACT []
synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT []
synonym: "salty taste detection" EXACT []
synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory detection of salty taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory transduction of salty taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
intersection_of: GO:0009593 ! detection of chemical stimulus
intersection_of: part_of GO:0050914 ! sensory perception of salty taste
relationship: part_of GO:0050914 ! sensory perception of salty taste

[Term]
id: GO:0001584
name: rhodopsin-like receptor activity
namespace: molecular_function
alt_id: GO:0001620
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
subset: gosubset_prok
synonym: "Class A G protein coupled receptor" EXACT []
synonym: "Class A G-protein coupled receptor" EXACT []
synonym: "Class A GPCR" EXACT []
synonym: "class A orphan receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001586
name: Gi/o-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247]
synonym: "5-HT1 receptor activity" EXACT [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf]
is_a: GO:0004993 ! serotonin receptor activity

[Term]
id: GO:0001587
name: Gq/11-coupled serotonin receptor activity
namespace: molecular_function
def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043]
synonym: "5-HT2 receptor activity" BROAD [GOC:bf]
synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf]
is_a: GO:0004993 ! serotonin receptor activity

[Term]
id: GO:0001588
name: dopamine receptor activity, coupled via Gs
namespace: molecular_function
alt_id: GO:0001589
alt_id: GO:0001590
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260]
synonym: "dopamine D1 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D5 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine receptor activity

[Term]
id: GO:0001591
name: dopamine receptor activity, coupled via Gi/Go
namespace: molecular_function
alt_id: GO:0001592
alt_id: GO:0001593
alt_id: GO:0001670
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258]
synonym: "dopamine D2 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D3 receptor activity" NARROW [GOC:bf]
synonym: "dopamine D4 receptor activity" NARROW [GOC:bf]
is_a: GO:0004952 ! dopamine receptor activity

[Term]
id: GO:0001594
name: trace-amine receptor activity
namespace: molecular_function
def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0001595
name: angiotensin receptor activity
namespace: molecular_function
def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity
relationship: part_of GO:0038166 ! angiotensin-mediated signaling pathway

[Term]
id: GO:0001596
name: angiotensin type I receptor activity
namespace: molecular_function
def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869]
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0001597
name: apelin-like receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because the function it represents does not exist.
synonym: "APJ-like receptor" EXACT []
is_obsolete: true
consider: GO:0031704

[Term]
id: GO:0001598
name: chemokine receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001601
name: peptide YY receptor activity
namespace: molecular_function
def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001602
name: pancreatic polypeptide receptor activity
namespace: molecular_function
def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001603
name: vasopressin-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators]
is_obsolete: true

[Term]
id: GO:0001604
name: urotensin II receptor activity
namespace: molecular_function
def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001605
name: adrenomedullin receptor activity
namespace: molecular_function
def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai]
synonym: "G10D receptor" NARROW []
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001606
name: GPR37/endothelin B-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001607
name: neuromedin U receptor activity
namespace: molecular_function
def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
synonym: "NMUR activity" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity
relationship: has_part GO:0042924 ! neuromedin U binding

[Term]
id: GO:0001608
name: G-protein coupled nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294]
synonym: "G protein coupled nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled nucleotide receptor activity" EXACT []
synonym: "nucleotide receptor activity, G protein coupled" EXACT []
synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001609
name: G-protein coupled adenosine receptor activity
namespace: molecular_function
alt_id: GO:0001610
alt_id: GO:0001611
alt_id: GO:0001612
alt_id: GO:0001613
alt_id: GO:0008501
def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289]
synonym: "A1 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "adenosine nucleotide receptor" BROAD []
synonym: "adenosine receptor activity, G protein coupled" EXACT []
synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled A1 adenosine receptor activity" NARROW []
synonym: "G protein coupled A2A adenosine receptor activity" NARROW []
synonym: "G protein coupled A2B adenosine receptor activity" NARROW []
synonym: "G protein coupled A3 adenosine receptor activity" NARROW []
synonym: "G protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled adenosine receptor activity" EXACT []
synonym: "P1 receptor" EXACT [PMID:9755289]
xref: Reactome:REACT_105855 "TRKA activation by adenosine A2a receptor, Bos taurus"
xref: Reactome:REACT_110350 "TRKA activation by adenosine A2a receptor, Canis familiaris"
xref: Reactome:REACT_11079 "TrkA activation by adenosine A2a receptor, Rattus norvegicus"
xref: Reactome:REACT_29695 "TRKA activation by adenosine A2a receptor, Sus scrofa"
xref: Reactome:REACT_36513 "TRKA activation by adenosine A2a receptor, Gallus gallus"
xref: Reactome:REACT_79823 "TRKA activation by adenosine A2a receptor, Danio rerio"
xref: Reactome:REACT_89799 "TRKA activation by adenosine A2a receptor, Taeniopygia guttata"
xref: Reactome:REACT_97530 "TRKA activation by adenosine A2a receptor, Xenopus tropicalis"
xref: Reactome:REACT_9980 "TRKA activation by adenosine A2a receptor, Homo sapiens"
xref: Reactome:REACT_99869 "TRKA activation by adenosine A2a receptor, Mus musculus"
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0035586 ! purinergic receptor activity
relationship: part_of GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0001614
name: purinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]
synonym: "P2 receptor" RELATED [PMID:9755289]
is_a: GO:0016502 ! nucleotide receptor activity
is_a: GO:0035586 ! purinergic receptor activity
relationship: has_part GO:0017076 ! purine nucleotide binding
relationship: part_of GO:0035590 ! purinergic nucleotide receptor signaling pathway

[Term]
id: GO:0001615
name: thyrotropin releasing hormone and secretagogue-like receptors activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001616
name: growth hormone secretagogue receptor activity
namespace: molecular_function
def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853]
synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001617
name: growth hormone secretagogue-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001618
name: viral receptor activity
namespace: molecular_function
def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403]
is_a: GO:0004872 ! receptor activity
relationship: part_of GO:0009615 ! response to virus

[Term]
id: GO:0001619
name: lysosphingolipid and lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph]
is_obsolete: true
consider: GO:0038036
consider: GO:0070915

[Term]
id: GO:0001621
name: ADP receptor activity
namespace: molecular_function
def: "Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:11196645]
synonym: "K101 receptor" NARROW []
synonym: "platelet ADP receptor activity" NARROW [GOC:mah]
is_a: GO:0045028 ! G-protein coupled purinergic nucleotide receptor activity
relationship: has_part GO:0043531 ! ADP binding

[Term]
id: GO:0001626
name: nociceptin receptor activity
namespace: molecular_function
def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432]
synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "OFQ receptor activity" EXACT [PR:000012940]
synonym: "ORPH receptor" EXACT []
synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf]
synonym: "X-opioid receptor activity" RELATED [GOC:bf]
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0001627
name: leucine-rich G-protein receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "leucine-rich G protein receptor-like receptor activity" EXACT []
synonym: "LGR-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001628
name: gastropyloric receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the gastropyloric receptor is a type of neuron.
synonym: "GPR receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001629
name: G-protein receptor 45-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "G protein receptor 45-like receptor activity" EXACT []
synonym: "GPR45-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001630
name: GP40-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001631
name: cysteinyl leukotriene receptor activity
namespace: molecular_function
def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]
synonym: "CysLT receptor" EXACT []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001632
name: leukotriene B4 receptor activity
namespace: molecular_function
def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732]
synonym: "BLT receptor" NARROW []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001633
name: secretin-like receptor activity
namespace: molecular_function
alt_id: GO:0001638
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class B G protein coupled receptor" EXACT []
synonym: "class B G-protein coupled receptor" EXACT []
synonym: "class B GPCR" EXACT []
synonym: "class B orphan receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001634
name: pituitary adenylate cyclase-activating polypeptide receptor activity
namespace: molecular_function
alt_id: GO:0016522
def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb]
synonym: "PACAP receptor" EXACT []
synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT []
synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED []
synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED []
synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT []
xref: Reactome:REACT_10128 "TRKA activation by PACAP type 1 receptor, Homo sapiens"
xref: Reactome:REACT_101685 "TRKA activation by PACAP type 1 receptor, Canis familiaris"
xref: Reactome:REACT_109490 "TRKA activation by PACAP type 1 receptor, Taeniopygia guttata"
xref: Reactome:REACT_11114 "TrkA activation by PACAP type 1 receptor, Rattus norvegicus"
xref: Reactome:REACT_34105 "TRKA activation by PACAP type 1 receptor, Mus musculus"
xref: Reactome:REACT_86120 "TRKA activation by PACAP type 1 receptor, Xenopus tropicalis"
xref: Reactome:REACT_87714 "TRKA activation by PACAP type 1 receptor, Bos taurus"
xref: Reactome:REACT_91558 "TRKA activation by PACAP type 1 receptor, Danio rerio"
xref: Reactome:REACT_92997 "TRKA activation by PACAP type 1 receptor, Gallus gallus"
xref: Reactome:REACT_96326 "TRKA activation by PACAP type 1 receptor, Sus scrofa"
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001635
name: calcitonin gene-related polypeptide receptor activity
namespace: molecular_function
def: "Combining with a calcitonin gene-related polypeptide to initiate a change in cell activity." [GOC:mah, PMID:12037140]
synonym: "CGRP receptor" EXACT []
xref: Wikipedia:CALCRL
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001636
name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001637
name: G-protein coupled chemoattractant receptor activity
namespace: molecular_function
def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah]
synonym: "G protein chemoattractant receptor activity" EXACT []
synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001639
name: PLC activating G-protein coupled glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303]
synonym: "Group I metabotropic glutamate receptor" RELATED []
synonym: "group I metabotropic glutamate receptor activity" RELATED []
synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT []
synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf]
is_a: GO:0008066 ! glutamate receptor activity
relationship: part_of GO:0007206 ! activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0001640
name: adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph]
synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf]
synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0008066 ! glutamate receptor activity
relationship: part_of GO:0007196 ! inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway

[Term]
id: GO:0001641
name: group II metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph]
is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

[Term]
id: GO:0001642
name: group III metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303]
is_a: GO:0001640 ! adenylate cyclase inhibiting G-protein coupled glutamate receptor activity

[Term]
id: GO:0001646
name: cAMP receptor activity
namespace: molecular_function
alt_id: GO:0001644
def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg]
synonym: "3',5' cAMP receptor activity" EXACT []
synonym: "3',5'-cAMP receptor activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT []
synonym: "class E G protein coupled receptor" BROAD []
synonym: "class E G-protein coupled receptor" BROAD []
synonym: "class E GPCR" BROAD []
synonym: "cyclic AMP receptor activity" EXACT []
is_a: GO:0001614 ! purinergic nucleotide receptor activity
relationship: has_part GO:0030552 ! cAMP binding

[Term]
id: GO:0001647
name: G-protein coupled cytokinin receptor activity
namespace: molecular_function
def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph]
synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf]
synonym: "G protein coupled cytokinin receptor activity" EXACT []
synonym: "G-protein-coupled cytokinin receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0001648
name: proteinase activated receptor activity
namespace: molecular_function
def: "A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985]
is_a: GO:0008528 ! G-protein coupled peptide receptor activity

[Term]
id: GO:0001649
name: osteoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid]
synonym: "osteoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0001650
name: fibrillar center
namespace: cellular_component
def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561]
synonym: "fibrillar centre" EXACT []
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001651
name: dense fibrillar component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001652
name: granular component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001653
name: peptide receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0038023 ! signaling receptor activity
relationship: has_part GO:0042277 ! peptide binding

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0001655
name: urogenital system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development

[Term]
id: GO:0001656
name: metanephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001657
name: ureteric bud development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0035295 ! tube development

[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0061138 ! morphogenesis of a branching epithelium
intersection_of: GO:0001763 ! morphogenesis of a branching structure
intersection_of: part_of GO:0060675 ! ureteric bud morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001660
name: fever generation
namespace: biological_process
def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl]
synonym: "pyrexia" BROAD []
xref: Wikipedia:Fever
is_a: GO:0006953 ! acute-phase response
is_a: GO:0031649 ! heat generation

[Term]
id: GO:0001661
name: conditioned taste aversion
namespace: biological_process
def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
xref: Wikipedia:Conditioned_taste_aversion
xref: Wikipedia:Taste_aversion
is_a: GO:0007631 ! feeding behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0001662
name: behavioral fear response
namespace: biological_process
def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659]
synonym: "behavioural fear response" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0042596 ! fear response

[Term]
id: GO:0001664
name: G-protein coupled receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein-coupled receptor binding" EXACT [GOC:bf]
synonym: "G-protein-coupled receptor ligand" NARROW []
xref: Reactome:REACT_21309 "Activation of GRIK3 homomer, Homo sapiens"
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001665
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3]
synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3]
synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3]
xref: EC:2.4.99.3
xref: MetaCyc:2.4.99.3-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to lowered oxygen tension" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0001667
name: ameboidal cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001669
name: acrosomal vesicle
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732]
synonym: "acrosomal granule" EXACT [GOC:sart]
synonym: "acrosome" RELATED [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0001671
name: ATPase activator activity
namespace: molecular_function
def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp]
synonym: "ATPase stimulator activity" EXACT []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0060590 ! ATPase regulator activity
relationship: part_of GO:0032781 ! positive regulation of ATPase activity
relationship: positively_regulates GO:0016887 ! ATPase activity

[Term]
id: GO:0001672
name: regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "regulation of chromatin assembly/disassembly" EXACT []
is_a: GO:0033044 ! regulation of chromosome organization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006333 ! chromatin assembly or disassembly
relationship: regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001675
name: acrosome assembly
namespace: biological_process
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0001676
name: long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18." [CHEBI:15904, GOC:ajp]
subset: gosubset_prok
synonym: "long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
subset: gosubset_prok
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001678
name: cellular glucose homeostasis
namespace: biological_process
def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042593 ! glucose homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0001680
name: tRNA 3'-terminal CCA addition
namespace: biological_process
def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators]
subset: gosubset_prok
synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CCA-adding enzyme activity" EXACT [EC:2.7.7.72]
synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" EXACT [EC:2.7.7.72]
synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" EXACT [EC:2.7.7.72]
synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72]
synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72]
synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72]
xref: EC:2.7.7.72
xref: KEGG:R09382
xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
is_a: GO:0042780 ! tRNA 3'-end processing
relationship: has_part GO:0052927 ! CTP:tRNA cytidylyltransferase activity
relationship: has_part GO:0052928 ! CTP:3'-cytidine-tRNA cytidylyltransferase activity
relationship: has_part GO:0052929 ! ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity

[Term]
id: GO:0001681
name: sialate O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039]
subset: gosubset_prok
synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53]
synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53]
synonym: "sialate 9(4)-O-acetylesterase activity" EXACT []
xref: EC:3.1.1.53
xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0001682
name: tRNA 5'-leader removal
namespace: biological_process
def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
subset: gosubset_prok
synonym: "tRNA 5' leader removal" EXACT []
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0001683
name: axonemal dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001684
name: axonemal dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001685
name: axonemal dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001686
name: axonemal dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001687
name: cytoplasmic dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001688
name: cytoplasmic dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001689
name: cytoplasmic dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001690
name: cytoplasmic dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001691
name: pseudophosphatase activity
namespace: molecular_function
def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp]
is_a: GO:0019212 ! phosphatase inhibitor activity

[Term]
id: GO:0001692
name: histamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0052803 ! imidazole-containing compound metabolic process

[Term]
id: GO:0001694
name: histamine biosynthetic process
namespace: biological_process
alt_id: GO:0001693
def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine anabolism" EXACT []
synonym: "histamine biosynthesis" EXACT []
synonym: "histamine formation" EXACT []
synonym: "histamine synthesis" EXACT []
xref: Reactome:REACT_115661 "Histidine is decarboxylated to histamine, Homo sapiens"
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0001695
name: histamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0052805 ! imidazole-containing compound catabolic process

[Term]
id: GO:0001696
name: gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0001697
name: histamine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001698
name: gastrin-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001699
name: acetylcholine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryo development ending in birth or egg hatching

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001702
name: gastrulation with mouth forming second
namespace: biological_process
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001703
name: gastrulation with mouth forming first
namespace: biological_process
def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "protostomic gastrulation" NARROW [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007492 ! endoderm development

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0001708
name: cell fate specification
namespace: biological_process
def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001709
name: cell fate determination
namespace: biological_process
def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
xref: Wikipedia:Cell_fate_determination
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001710
name: mesodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "mesoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:0001711
name: endodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "endoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0035987 ! endodermal cell differentiation

[Term]
id: GO:0001712
name: ectodermal cell fate commitment
namespace: biological_process
def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer
relationship: part_of GO:0001705 ! ectoderm formation
relationship: part_of GO:0010668 ! ectodermal cell differentiation

[Term]
id: GO:0001713
name: ectodermal cell fate determination
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001714
name: endodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "endoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0001715
name: ectodermal cell fate specification
namespace: biological_process
def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "ectoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001716
name: L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2]
subset: gosubset_prok
synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2]
synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2]
xref: EC:1.4.3.2
xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN
xref: RHEA:13784
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0001717
name: conversion of seryl-tRNAsec to selenocys-tRNAsec
namespace: biological_process
def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001720
name: conversion of lysyl-tRNA to pyrrolysyl-tRNA
namespace: biological_process
def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001721
name: intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "IFAP" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001722
name: type I intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001723
name: type II intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001724
name: type III intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0001725
name: stress fiber
namespace: cellular_component
def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]
synonym: "actin cable" RELATED [GOC:mah]
synonym: "stress fibre" EXACT []
is_a: GO:0032432 ! actin filament bundle
is_a: GO:0042641 ! actomyosin

[Term]
id: GO:0001726
name: ruffle
namespace: cellular_component
def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
synonym: "membrane ruffle" RELATED []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0001727
name: lipid kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity
relationship: part_of GO:0046834 ! lipid phosphorylation

[Term]
id: GO:0001729
name: ceramide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138]
synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138]
synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138]
xref: EC:2.7.1.138
xref: MetaCyc:CERAMIDE-KINASE-RXN
xref: Reactome:REACT_116045 "Ceramide kinase (CERK) mediates the phosphorylation of ceramide, Homo sapiens"
xref: RHEA:17932
is_a: GO:0001727 ! lipid kinase activity

[Term]
id: GO:0001730
name: 2'-5'-oligoadenylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732]
synonym: "(2-5')oligo(A) synthetase activity" EXACT []
synonym: "2'-5' oligoadenylate synthetase activity" EXACT []
synonym: "2-5A synthetase activity" EXACT []
synonym: "oligo-2',5'-adenylate synthetase activity" EXACT []
xref: MetaCyc:RXN-10798
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0001731
name: formation of translation preinitiation complex
namespace: biological_process
def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children.
subset: gosubset_prok
synonym: "formation of translation pre-initiation complex" EXACT []
synonym: "translation preinitiation complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001732
name: formation of translation initiation complex
namespace: biological_process
def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd]
subset: gosubset_prok
synonym: "translation initiation complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001733
name: galactosylceramide sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929]
synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "cerebroside sulfotransferase activity" EXACT []
synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactosylceramide sulphotransferase activity" EXACT []
synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "GSase" EXACT [EC:2.8.2.11]
xref: EC:2.8.2.11
xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN
xref: Reactome:REACT_115577 "Galactosylceramide sulfotransferase (GAL3ST1) mediates the sulfation of membrane glycolipids, Homo sapiens"
xref: RHEA:20616
is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity

[Term]
id: GO:0001734
name: mRNA (N6-adenosine)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd]
xref: Reactome:REACT_101890 "Internal Methylation of mRNA, Oryza sativa"
xref: Reactome:REACT_1720 "Internal Methylation of mRNA, Homo sapiens"
xref: Reactome:REACT_28538 "Internal Methylation of mRNA, Canis familiaris"
xref: Reactome:REACT_28726 "Internal Methylation of mRNA, Arabidopsis thaliana"
xref: Reactome:REACT_30916 "Internal Methylation of mRNA, Drosophila melanogaster"
xref: Reactome:REACT_32129 "Internal Methylation of mRNA, Rattus norvegicus"
xref: Reactome:REACT_85371 "Internal Methylation of mRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_88666 "Internal Methylation of mRNA, Mus musculus"
xref: Reactome:REACT_90117 "Internal Methylation of mRNA, Bos taurus"
xref: Reactome:REACT_91818 "Internal Methylation of mRNA, Plasmodium falciparum"
xref: Reactome:REACT_92618 "Internal Methylation of mRNA, Danio rerio"
xref: Reactome:REACT_96892 "Internal Methylation of mRNA, Xenopus tropicalis"
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0001735
name: prenylcysteine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd]
synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5]
synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5]
xref: EC:1.8.3.5
xref: MetaCyc:1.8.3.5-RXN
is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0001736
name: establishment of planar polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
synonym: "establishment of planar cell polarity" NARROW []
is_a: GO:0007164 ! establishment of tissue polarity
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0001737
name: establishment of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
synonym: "establishment of wing hair orientation" EXACT []
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0001738
name: morphogenesis of a polarized epithelium
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
synonym: "epithelial polarization" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732]
is_a: GO:0005720 ! nuclear heterochromatin
intersection_of: GO:0005720 ! nuclear heterochromatin
intersection_of: part_of GO:0000803 ! sex chromosome
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0001740
name: Barr body
namespace: cellular_component
def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
xref: Wikipedia:Barr_body
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000805 ! X chromosome
relationship: has_part GO:0001739 ! sex chromatin

[Term]
id: GO:0001741
name: XY body
namespace: cellular_component
def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
is_a: GO:0000803 ! sex chromosome
relationship: has_part GO:0001739 ! sex chromatin

[Term]
id: GO:0001742
name: oenocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators]
synonym: "oenocyte cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0001743
name: optic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0001744
name: optic lobe placode formation
namespace: biological_process
alt_id: GO:0007457
def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor formation" EXACT []
is_a: GO:0001743 ! optic placode formation
relationship: part_of GO:0001748 ! optic lobe placode development

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0001746
name: Bolwig's organ morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0055034 ! Bolwig's organ development

[Term]
id: GO:0001748
name: optic lobe placode development
namespace: biological_process
alt_id: GO:0048049
def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor development" EXACT []
synonym: "optic placode development" BROAD []
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0001750
name: photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820]
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0001752
name: compound eye photoreceptor fate commitment
namespace: biological_process
alt_id: GO:0007459
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0001753
name: adult eye photoreceptor development (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators]
comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins.
is_obsolete: true
consider: GO:0042051

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0014032 ! neural crest cell development

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern specification
is_a: GO:0035282 ! segmentation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0043009 ! chordate embryonic development
relationship: part_of GO:0061053 ! somite development

[Term]
id: GO:0001757
name: somite specification
namespace: biological_process
def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph]
is_a: GO:0007379 ! segment specification
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0001758
name: retinal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36]
synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36]
xref: EC:1.2.1.36
xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN
xref: RHEA:16180
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0001759
name: organ induction
namespace: biological_process
def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437]
synonym: "induction of an organ" EXACT [GOC:curators]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0031128 ! developmental induction
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0010092 ! specification of organ identity

[Term]
id: GO:0001760
name: aminocarboxymuconate-semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16560]
subset: gosubset_prok
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45]
xref: EC:4.1.1.45
xref: KEGG:R04323
xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
xref: RHEA:16560
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0001761
name: beta-alanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd]
synonym: "beta-alanine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
relationship: part_of GO:0001762 ! beta-alanine transport

[Term]
id: GO:0001762
name: beta-alanine transport
namespace: biological_process
def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd]
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators]
synonym: "neuron chemotaxis" EXACT [GOC:curators]
synonym: "neuron guidance" RELATED [GOC:curators]
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0001765
name: membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198]
synonym: "lipid raft assembly" EXACT [GOC:mah]
synonym: "lipid raft formation" RELATED []
synonym: "membrane raft formation" RELATED [GOC:mah]
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0071844 ! cellular component assembly at cellular level

[Term]
id: GO:0001766
name: membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889]
synonym: "lipid raft polarization" EXACT []
is_a: GO:0031580 ! membrane raft distribution

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042110 ! T cell activation

[Term]
id: GO:0001769
name: establishment of B cell polarity
namespace: biological_process
def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889]
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
synonym: "B cell polarization" EXACT []
synonym: "B lymphocyte polarization" EXACT []
synonym: "B-cell polarization" EXACT []
synonym: "establishment of B lymphocyte polarity" EXACT []
synonym: "establishment of B-cell polarity" EXACT []
synonym: "establishment of B-lymphocyte polarity" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042113 ! B cell activation

[Term]
id: GO:0001770
name: establishment of natural killer cell polarity
namespace: biological_process
def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849]
synonym: "establishment of NK cell polarity" EXACT []
synonym: "natural killer cell polarization" EXACT []
synonym: "NK cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001771
name: immunological synapse formation
namespace: biological_process
def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330]
synonym: "formation of immunological synapse" EXACT [GOC:curators]
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001772
name: immunological synapse
namespace: cellular_component
def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300]
synonym: "c-SMAC" NARROW [PMID:14724296]
synonym: "supramolecular activation cluster" EXACT [PMID:14724296]
xref: Wikipedia:Immunological_synapse
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
namespace: biological_process
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0001774
name: microglial cell activation
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
is_a: GO:0042116 ! macrophage activation

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0001778
name: plasma membrane repair
namespace: biological_process
def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0001779
name: natural killer cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development" RELATED [GOC:add]
synonym: "NK cell differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001780
name: neutrophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:12752675, PMID:12960266]
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0001781
name: neutrophil apoptotic process
namespace: biological_process
def: "The process of apoptosis in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266]
synonym: "apoptosis of neutrophils" EXACT []
synonym: "neutrophil apoptosis" NARROW []
synonym: "neutrophil programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neutrophils by apoptosis" EXACT []
synonym: "programmed cell death, neutrophils" EXACT []
is_a: GO:0006925 ! inflammatory cell apoptotic process
is_a: GO:0033028 ! myeloid cell apoptotic process
relationship: part_of GO:0001780 ! neutrophil homeostasis

[Term]
id: GO:0001782
name: B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429]
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B lymphocyte homeostasis" EXACT []
synonym: "B-cell homeostasis" EXACT []
synonym: "B-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0001783
name: B cell apoptotic process
namespace: biological_process
def: "The process of apoptosis in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of B cells" EXACT []
synonym: "apoptosis of B lymphocytes" EXACT []
synonym: "apoptosis of B-cells" EXACT []
synonym: "apoptosis of B-lymphocytes" EXACT []
synonym: "B cell apoptosis" NARROW []
synonym: "B cell programmed cell death by apoptosis" EXACT []
synonym: "B lymphocyte apoptosis" EXACT []
synonym: "B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "B-cell apoptosis" EXACT []
synonym: "B-cell programmed cell death by apoptosis" EXACT []
synonym: "B-lymphocyte apoptosis" EXACT []
synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of B cells by apoptosis" EXACT []
synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of B-cells by apoptosis" EXACT []
synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, B cells" EXACT []
synonym: "programmed cell death, B lymphocytes" EXACT []
synonym: "programmed cell death, B-cells" EXACT []
synonym: "programmed cell death, B-lymphocytes" EXACT []
is_a: GO:0070227 ! lymphocyte apoptotic process

[Term]
id: GO:0001784
name: phosphotyrosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584]
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0001785
name: prostaglandin J receptor activity
namespace: molecular_function
def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180]
synonym: "PGJ receptor activity" RELATED []
synonym: "PGJ(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0001786
name: phosphatidylserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0001787
name: natural killer cell proliferation
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149]
synonym: "NK cell proliferation" EXACT []
is_a: GO:0030101 ! natural killer cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0001788
name: antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [ISBN:0781735149, PMID:11677095, PMID:9581795]
synonym: "ADCC" EXACT []
synonym: "antibody dependent cell death" EXACT []
synonym: "antibody dependent cell killing" EXACT []
synonym: "antibody-dependent cell death" EXACT []
synonym: "antibody-dependent cell killing" EXACT []
synonym: "type VI hypersensitivity" EXACT []
xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity
is_a: GO:0001794 ! type IIa hypersensitivity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001789
name: G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating)
namespace: biological_process
def: "A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate." [GOC:dph, PMID:14592418]
synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway

[Term]
id: GO:0001790
name: polymeric immunoglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001791
name: IgM binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001792
name: polymeric immunoglobulin receptor activity
namespace: molecular_function
def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0001790 ! polymeric immunoglobulin binding

[Term]
id: GO:0001793
name: IgM receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0019763 ! immunoglobulin receptor activity
relationship: has_part GO:0001791 ! IgM binding

[Term]
id: GO:0001794
name: type IIa hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149]
comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001795
name: type IIb hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
synonym: "type V hypersensitivity" EXACT []
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001796
name: regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001794 ! type IIa hypersensitivity
relationship: regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001797
name: negative regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIa hypersensitivity" EXACT []
synonym: "down-regulation of type IIa hypersensitivity" EXACT []
synonym: "downregulation of type IIa hypersensitivity" EXACT []
synonym: "inhibition of type IIa hypersensitivity" NARROW []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001794 ! type IIa hypersensitivity
relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001798
name: positive regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIa hypersensitivity" NARROW []
synonym: "stimulation of type IIa hypersensitivity" NARROW []
synonym: "up regulation of type IIa hypersensitivity" EXACT []
synonym: "up-regulation of type IIa hypersensitivity" EXACT []
synonym: "upregulation of type IIa hypersensitivity" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001794 ! type IIa hypersensitivity
relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001799
name: regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001795 ! type IIb hypersensitivity
relationship: regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001800
name: negative regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IIb hypersensitivity" EXACT []
synonym: "down-regulation of type IIb hypersensitivity" EXACT []
synonym: "downregulation of type IIb hypersensitivity" EXACT []
synonym: "inhibition of type IIb hypersensitivity" NARROW []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001795 ! type IIb hypersensitivity
relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001801
name: positive regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IIb hypersensitivity" NARROW []
synonym: "stimulation of type IIb hypersensitivity" NARROW []
synonym: "up regulation of type IIb hypersensitivity" EXACT []
synonym: "up-regulation of type IIb hypersensitivity" EXACT []
synonym: "upregulation of type IIb hypersensitivity" EXACT []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001795 ! type IIb hypersensitivity
relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001802
name: type III hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149]
comment: Note that the Arthus reaction is an example of type III hypersensitivity.
xref: Wikipedia:Type_III_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0001803
name: regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001802 ! type III hypersensitivity
relationship: regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001804
name: negative regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type III hypersensitivity" EXACT []
synonym: "down-regulation of type III hypersensitivity" EXACT []
synonym: "downregulation of type III hypersensitivity" EXACT []
synonym: "inhibition of type III hypersensitivity" NARROW []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001802 ! type III hypersensitivity
relationship: negatively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001805
name: positive regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type III hypersensitivity" NARROW []
synonym: "stimulation of type III hypersensitivity" NARROW []
synonym: "up regulation of type III hypersensitivity" EXACT []
synonym: "up-regulation of type III hypersensitivity" EXACT []
synonym: "upregulation of type III hypersensitivity" EXACT []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001802 ! type III hypersensitivity
relationship: positively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001806
name: type IV hypersensitivity
namespace: biological_process
alt_id: GO:0016069
def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149]
synonym: "delayed hypersensitivity response" EXACT []
synonym: "delayed-type hypersensitivity" EXACT []
xref: Wikipedia:Type_IV_hypersensitivity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002524 ! hypersensitivity

[Term]
id: GO:0001807
name: regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001806 ! type IV hypersensitivity
relationship: regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001808
name: negative regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type IV hypersensitivity" EXACT []
synonym: "down-regulation of type IV hypersensitivity" EXACT []
synonym: "downregulation of type IV hypersensitivity" EXACT []
synonym: "inhibition of type IV hypersensitivity" NARROW []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002884 ! negative regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001806 ! type IV hypersensitivity
relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001809
name: positive regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type IV hypersensitivity" NARROW []
synonym: "stimulation of type IV hypersensitivity" NARROW []
synonym: "up regulation of type IV hypersensitivity" EXACT []
synonym: "up-regulation of type IV hypersensitivity" EXACT []
synonym: "upregulation of type IV hypersensitivity" EXACT []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002885 ! positive regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001806 ! type IV hypersensitivity
relationship: positively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001810
name: regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016068 ! type I hypersensitivity
relationship: regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001811
name: negative regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "down regulation of type I hypersensitivity" EXACT []
synonym: "down-regulation of type I hypersensitivity" EXACT []
synonym: "downregulation of type I hypersensitivity" EXACT []
synonym: "inhibition of type I hypersensitivity" NARROW []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016068 ! type I hypersensitivity
relationship: negatively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001812
name: positive regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "activation of type I hypersensitivity" NARROW []
synonym: "stimulation of type I hypersensitivity" NARROW []
synonym: "up regulation of type I hypersensitivity" EXACT []
synonym: "up-regulation of type I hypersensitivity" EXACT []
synonym: "upregulation of type I hypersensitivity" EXACT []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016068 ! type I hypersensitivity
relationship: positively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001813
name: regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of antibody dependent cell death" EXACT []
synonym: "regulation of antibody dependent cell killing" EXACT []
synonym: "regulation of antibody-dependent cell death" EXACT []
synonym: "regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001814
name: negative regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "negative regulation of antibody dependent cell death" EXACT []
synonym: "negative regulation of antibody dependent cell killing" EXACT []
synonym: "negative regulation of antibody-dependent cell death" EXACT []
synonym: "negative regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001815
name: positive regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "positive regulation of antibody dependent cell death" EXACT []
synonym: "positive regulation of antibody dependent cell killing" EXACT []
synonym: "positive regulation of antibody-dependent cell death" EXACT []
synonym: "positive regulation of antibody-dependent cell killing" EXACT []
synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT []
is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity
relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subset: goslim_pir
synonym: "interferon production" NARROW [GOC:add, GOC:mah]
synonym: "interleukin production" NARROW [GOC:add, GOC:mah]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
is_a: GO:0051239 ! regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001816 ! cytokine production
relationship: regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine production" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001816 ! cytokine production
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]
synonym: "activation of cytokine production" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001816 ! cytokine production
relationship: positively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
synonym: "serotonin release" RELATED [GOC:tb]
is_a: GO:0006837 ! serotonin transport
is_a: GO:0023061 ! signal release
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0001821
name: histamine secretion
namespace: biological_process
def: "The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149]
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0001822
name: kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]
synonym: "nephrogenesis" RELATED [GOC:dph, GOC:tb]
xref: Wikipedia:Kidney_development
is_a: GO:0048513 ! organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0001823
name: mesonephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001701 ! in utero embryonic development

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001827
name: inner cell mass cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001828
name: inner cell mass cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001830
name: trophectodermal cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell fate commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001835
name: blastocyst hatching
namespace: biological_process
def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
is_a: GO:0035188 ! hatching
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001836
name: release of cytochrome c from mitochondria
namespace: biological_process
def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:add, GOC:mah, ISBN:0721639976, PMID:12925707, PMID:9560217]
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0014031 ! mesenchymal cell development

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001840 ! neural plate development

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
synonym: "neural groove formation" RELATED [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001843
name: neural tube closure
namespace: biological_process
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001844
name: protein insertion into mitochondrial membrane involved in induction of apoptosis
namespace: biological_process
def: "The process in which a protein is incorporated into a mitochondrial membrane, contributing to the induction of apoptosis." [GOC:add, PMID:12952892]
comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" EXACT []
synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" RELATED [GOC:dph, GOC:tb]
synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" EXACT []
xref: Reactome:REACT_101395 "Translocation of BMF to mitochondria, Gallus gallus"
xref: Reactome:REACT_101818 "Translocation of BIM to mitochondria, Sus scrofa"
xref: Reactome:REACT_102379 "Translocation of BIM to mitochondria, Bos taurus"
xref: Reactome:REACT_104 "Translocation of PUMA protein to mitochondria, Homo sapiens"
xref: Reactome:REACT_105818 "Translocation of BIM to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_105883 "Translocation of activated BAD protein to mitochondria, Bos taurus"
xref: Reactome:REACT_109143 "Translocation of activated BAX to the mitochondria, Danio rerio"
xref: Reactome:REACT_110253 "Translocation of BMF to mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_110902 "Translocation of activated BAD protein to mitochondria, Sus scrofa"
xref: Reactome:REACT_112264 "Translocation of activated BAD protein to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_112484 "Translocation of NOXA to mitochondria, Mus musculus"
xref: Reactome:REACT_112773 "Translocation of NOXA to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_113120 "Translocation of BIM to mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_113968 "Translocation of NOXA to mitochondria, Sus scrofa"
xref: Reactome:REACT_115488 "Translocation of NOXA to mitochondria, Canis familiaris"
xref: Reactome:REACT_1286 "Translocation of activated BAX to the mitochondria, Homo sapiens"
xref: Reactome:REACT_1585 "Translocation of NOXA to mitochondria, Homo sapiens"
xref: Reactome:REACT_2046 "Translocation of activated BAD protein to mitochondria, Homo sapiens"
xref: Reactome:REACT_32202 "Translocation of activated BAX to the mitochondria, Xenopus tropicalis"
xref: Reactome:REACT_32704 "Translocation of activated BAD protein to mitochondria, Canis familiaris"
xref: Reactome:REACT_600 "Translocation of BMF to mitochondria, Homo sapiens"
xref: Reactome:REACT_750 "Translocation of BIM to mitochondria, Homo sapiens"
xref: Reactome:REACT_78961 "Translocation of activated BAD protein to mitochondria, Danio rerio"
xref: Reactome:REACT_81932 "Translocation of activated BAX to the mitochondria, Bos taurus"
xref: Reactome:REACT_83771 "Translocation of BMF to mitochondria, Bos taurus"
xref: Reactome:REACT_85921 "Translocation of BIM to mitochondria, Canis familiaris"
xref: Reactome:REACT_87251 "Translocation of activated BAD protein to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_87865 "Translocation of activated BAX to the mitochondria, Rattus norvegicus"
xref: Reactome:REACT_89314 "Translocation of BMF to mitochondria, Rattus norvegicus"
xref: Reactome:REACT_91622 "Translocation of activated BAD protein to mitochondria, Mus musculus"
xref: Reactome:REACT_92580 "Translocation of activated BAX to the mitochondria, Mus musculus"
xref: Reactome:REACT_94530 "Translocation of BMF to mitochondria, Mus musculus"
xref: Reactome:REACT_95929 "Translocation of BIM to mitochondria, Mus musculus"
xref: Reactome:REACT_97369 "Translocation of activated BAX to the mitochondria, Taeniopygia guttata"
xref: Reactome:REACT_97409 "Translocation of activated BAX to the mitochondria, Sus scrofa"
xref: Reactome:REACT_97453 "Translocation of BMF to mitochondria, Canis familiaris"
xref: Reactome:REACT_99030 "Translocation of activated BAX to the mitochondria, Canis familiaris"
xref: Reactome:REACT_99700 "Translocation of BMF to mitochondria, Xenopus tropicalis"
is_a: GO:0008637 ! apoptotic mitochondrial changes
is_a: GO:0051204 ! protein insertion into mitochondrial membrane
intersection_of: GO:0051204 ! protein insertion into mitochondrial membrane
intersection_of: part_of GO:0006917 ! induction of apoptosis
relationship: part_of GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001845
name: phagolysosome assembly
namespace: biological_process
def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149]
synonym: "late phagosome biosynthesis" RELATED []
synonym: "late phagosome formation" RELATED []
synonym: "phagolysosome formation" RELATED [GOC:mah]
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0090382 ! phagosome maturation

[Term]
id: GO:0001846
name: opsonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149]
comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001847
name: opsonin receptor activity
namespace: molecular_function
def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004888 ! transmembrane signaling receptor activity
relationship: has_part GO:0001846 ! opsonin binding

[Term]
id: GO:0001848
name: complement binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001849
name: complement component C1q binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001850
name: complement component C3a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001851
name: complement component C3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001852
name: complement component iC3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001853
name: complement component C3dg binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001854
name: complement component C3d binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001855
name: complement component C4b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001856
name: complement component C5a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001857
name: complement component C1q receptor activity
namespace: molecular_function
def: "Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001849 ! complement component C1q binding

[Term]
id: GO:0001858
name: complement component iC3b receptor activity
namespace: molecular_function
def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001852 ! complement component iC3b binding

[Term]
id: GO:0001859
name: complement component C3dg receptor activity
namespace: molecular_function
def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001853 ! complement component C3dg binding

[Term]
id: GO:0001860
name: complement component C3d receptor activity
namespace: molecular_function
def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001854 ! complement component C3d binding

[Term]
id: GO:0001861
name: complement component C4b receptor activity
namespace: molecular_function
def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0004875 ! complement receptor activity
relationship: has_part GO:0001855 ! complement component C4b binding

[Term]
id: GO:0001862
name: collectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001863
name: collectin receptor activity
namespace: molecular_function
def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]
comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001847 ! opsonin receptor activity
relationship: has_part GO:0001862 ! collectin binding

[Term]
id: GO:0001864
name: pentraxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001865
name: NK T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer T cell differentiation" EXACT []
synonym: "natural T cell differentiation" EXACT []
synonym: "NK T cell development" RELATED [GOC:add]
synonym: "NK T lymphocyte differentiation" EXACT []
synonym: "NK T-cell differentiation" EXACT []
synonym: "NK T-lymphocyte differentiation" EXACT []
synonym: "NKT cell differentiation" EXACT []
synonym: "NT cell differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0001866
name: NK T cell proliferation
namespace: biological_process
def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell proliferation" EXACT []
synonym: "natural T cell proliferation" EXACT []
synonym: "NK T lymphocyte proliferation" EXACT []
synonym: "NK T-cell proliferation" EXACT []
synonym: "NK T-lymphocyte proliferation" EXACT []
synonym: "NKT cell proliferation" EXACT []
synonym: "NT cell proliferation" EXACT []
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0001867
name: complement activation, lectin pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]
comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
synonym: "complement cascade, lectin pathway" EXACT [GOC:add]
xref: Reactome:REACT_114752 "Lectin pathway of complement activation, Canis familiaris"
xref: Reactome:REACT_30334 "Lectin pathway of complement activation, Rattus norvegicus"
xref: Reactome:REACT_31122 "Lectin pathway of complement activation, Bos taurus"
xref: Reactome:REACT_33084 "Lectin pathway of complement activation, Mus musculus"
xref: Reactome:REACT_7964 "Lectin pathway of complement activation, Homo sapiens"
xref: Reactome:REACT_89631 "Lectin pathway of complement activation, Sus scrofa"
xref: Reactome:REACT_96749 "Lectin pathway of complement activation, Gallus gallus"
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0001868
name: regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149]
synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001867 ! complement activation, lectin pathway
relationship: regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001869
name: negative regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "down regulation of complement activation, lectin pathway" EXACT []
synonym: "down-regulation of complement activation, lectin pathway" EXACT []
synonym: "downregulation of complement activation, lectin pathway" EXACT []
synonym: "inhibition of complement activation, lectin pathway" NARROW []
synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add]
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001867 ! complement activation, lectin pathway
relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001870
name: positive regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]
synonym: "activation of complement activation, lectin pathway" NARROW []
synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add]
synonym: "stimulation of complement activation, lectin pathway" NARROW []
synonym: "up regulation of complement activation, lectin pathway" EXACT []
synonym: "up-regulation of complement activation, lectin pathway" EXACT []
synonym: "upregulation of complement activation, lectin pathway" EXACT []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001867 ! complement activation, lectin pathway
relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001871
name: pattern binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]
comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead.
subset: goslim_pir
subset: gosubset_prok
synonym: "pattern recognition activity" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001872
name: (1->3)-beta-D-glucan binding
namespace: molecular_function
alt_id: GO:0080087
def: "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091]
synonym: "1,3-beta-D-glucan binding" EXACT []
synonym: "callose binding" NARROW []
synonym: "zymosan binding" NARROW [GOC:tb]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001873
name: polysaccharide receptor activity
namespace: molecular_function
def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091]
is_a: GO:0008329 ! pattern recognition receptor activity
relationship: has_part GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001874
name: (1->3)-beta-D-glucan receptor activity
namespace: molecular_function
def: "Combining with (1->3)-beta-D-glucans to initiate a change in cell activity." [PMID:14707091]
synonym: "(1,3)-beta-D-glucan receptor activity" EXACT []
synonym: "1,3-beta-D-glucan receptor activity" EXACT []
synonym: "beta-1,3-D-glucan receptor activity" EXACT []
synonym: "zymosan receptor activity" NARROW [GOC:tb]
is_a: GO:0001873 ! polysaccharide receptor activity
relationship: has_part GO:0001872 ! (1->3)-beta-D-glucan binding

[Term]
id: GO:0001875
name: lipopolysaccharide receptor activity
namespace: molecular_function
def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]
synonym: "endotoxin receptor activity" BROAD []
synonym: "LPS receptor activity" EXACT []
is_a: GO:0008329 ! pattern recognition receptor activity
relationship: has_part GO:0001530 ! lipopolysaccharide binding
relationship: part_of GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0001876
name: lipoarabinomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073]
synonym: "LAM binding" EXACT []
is_a: GO:0001871 ! pattern binding

[Term]
id: GO:0001877
name: lipoarabinomannan receptor activity
namespace: molecular_function
def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073]
synonym: "LAM receptor activity" EXACT []
is_a: GO:0008329 ! pattern recognition receptor activity
relationship: has_part GO:0001876 ! lipoarabinomannan binding

[Term]
id: GO:0001878
name: response to yeast
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0001879
name: detection of yeast
namespace: biological_process
def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091]
is_a: GO:0001878 ! response to yeast
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0001880
name: Mullerian duct regression
namespace: biological_process
def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913]
is_a: GO:0003006 ! developmental process involved in reproduction
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0001881
name: receptor recycling
namespace: biological_process
def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]
is_a: GO:0043112 ! receptor metabolic process
relationship: part_of GO:0023051 ! regulation of signaling

[Term]
id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0001883
name: purine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001884
name: pyrimidine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
relationship: part_of GO:0001885 ! endothelial cell development

[Term]
id: GO:0001887
name: selenium compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456]
subset: gosubset_prok
synonym: "selenium compound metabolism" EXACT []
synonym: "selenium metabolic process" EXACT []
synonym: "selenium metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0001888
name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223]
synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223]
synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223]
xref: EC:2.4.1.223
xref: MetaCyc:2.4.1.223-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0001889
name: liver development
namespace: biological_process
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0001890
name: placenta development
namespace: biological_process
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001893
name: maternal placenta development
namespace: biological_process
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: part_of GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001895
name: retina homeostasis
namespace: biological_process
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0001896
name: autolysis
namespace: biological_process
def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add]
subset: gosubset_prok
xref: Wikipedia:Autolysis
is_a: GO:0019835 ! cytolysis

[Term]
id: GO:0001897
name: cytolysis by symbiont of host cells
namespace: biological_process
def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "cytolysis by organism of host cells" EXACT []
is_a: GO:0001907 ! killing by symbiont of host cells
is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction
is_a: GO:0052025 ! modification by symbiont of host cell membrane

[Term]
id: GO:0001898
name: regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001899
name: negative regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "downregulation by symbiont of cytolysis of host cells" EXACT []
synonym: "inhibition by symbiont of cytolysis of host cells" NARROW []
synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001900
name: positive regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation by symbiont of cytolysis of host cells" NARROW []
synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation by symbiont of cytolysis of host cells" NARROW []
synonym: "up regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "upregulation by symbiont of cytolysis of host cells" EXACT []
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells
relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001905
name: activation of membrane attack complex
namespace: biological_process
def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149]
synonym: "activation of MAC" EXACT []
synonym: "activation of TCC" NARROW []
synonym: "activation of terminal complement complex" NARROW [GOC:add]
synonym: "activation of the terminal complement cascade" NARROW []
synonym: "MAC assembly" EXACT [GOC:rl]
synonym: "MAC formation" EXACT [GOC:rl]
synonym: "membrane attack complex assembly" EXACT [GOC:rl]
synonym: "membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0006956 ! complement activation

[Term]
id: GO:0001906
name: cell killing
namespace: biological_process
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "necrosis" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0001907
name: killing by symbiont of host cells
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cells
is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction

[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826]
comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
synonym: "immune cell mediated cell death" EXACT []
synonym: "immune cell mediated cell killing" EXACT []
synonym: "immune cell mediated cytotoxicity" EXACT []
synonym: "leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "regulation of immune cell mediated cell death" EXACT []
synonym: "regulation of immune cell mediated cell killing" EXACT []
synonym: "regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0031341 ! regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW []
synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0031342 ! negative regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]
synonym: "activation of leukocyte mediated cytotoxicity" NARROW []
synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW []
synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0031343 ! positive regulation of cell killing
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity
relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:11911826]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
synonym: "T cell mediated apoptosis" EXACT []
synonym: "T cell mediated cell death" EXACT []
synonym: "T cell mediated cell killing" EXACT []
synonym: "T cell mediated cytolysis" RELATED []
synonym: "T lymphocyte mediated cytotoxicity" EXACT []
synonym: "T-cell mediated apoptosis" EXACT []
synonym: "T-cell mediated cell death" EXACT []
synonym: "T-cell mediated cell killing" EXACT []
synonym: "T-cell mediated cytotoxicity" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001914
name: regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "regulation of T cell mediated apoptosis" EXACT []
synonym: "regulation of T cell mediated cell death" EXACT []
synonym: "regulation of T cell mediated cell killing" EXACT []
synonym: "regulation of T cell mediated cytolysis" RELATED []
synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "regulation of T-cell mediated apoptosis" EXACT []
synonym: "regulation of T-cell mediated cell death" EXACT []
synonym: "regulation of T-cell mediated cell killing" EXACT []
synonym: "regulation of T-cell mediated cytolysis" RELATED []
synonym: "regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "down regulation of T cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of T cell mediated apoptosis" EXACT []
synonym: "negative regulation of T cell mediated cell death" EXACT []
synonym: "negative regulation of T cell mediated cell killing" EXACT []
synonym: "negative regulation of T cell mediated cytolysis" RELATED []
synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-cell mediated apoptosis" EXACT []
synonym: "negative regulation of T-cell mediated cell death" EXACT []
synonym: "negative regulation of T-cell mediated cell killing" EXACT []
synonym: "negative regulation of T-cell mediated cytolysis" RELATED []
synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]
synonym: "activation of T cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of T cell mediated apoptosis" EXACT []
synonym: "positive regulation of T cell mediated cell death" EXACT []
synonym: "positive regulation of T cell mediated cell killing" EXACT []
synonym: "positive regulation of T cell mediated cytolysis" RELATED []
synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-cell mediated apoptosis" EXACT []
synonym: "positive regulation of T-cell mediated cell death" EXACT []
synonym: "positive regulation of T-cell mediated cell killing" EXACT []
synonym: "positive regulation of T-cell mediated cytolysis" RELATED []
synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of T cell mediated cytotoxicity" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001913 ! T cell mediated cytotoxicity
relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0001918
name: farnesylated protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001919
name: regulation of receptor recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
is_a: GO:0023051 ! regulation of signaling
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001881 ! receptor recycling
relationship: regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001920
name: negative regulation of receptor recycling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add]
synonym: "down regulation of receptor recycling" EXACT []
synonym: "down-regulation of receptor recycling" EXACT []
synonym: "downregulation of receptor recycling" EXACT []
synonym: "inhibition of receptor recycling" NARROW []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0031324 ! negative regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001881 ! receptor recycling
relationship: negatively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001921
name: positive regulation of receptor recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add]
synonym: "activation of receptor recycling" NARROW []
synonym: "stimulation of receptor recycling" NARROW []
synonym: "up regulation of receptor recycling" EXACT []
synonym: "up-regulation of receptor recycling" EXACT []
synonym: "upregulation of receptor recycling" EXACT []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0023056 ! positive regulation of signaling
is_a: GO:0031325 ! positive regulation of cellular metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001881 ! receptor recycling
relationship: positively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001922
name: B-1 B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B-1 B lymphocyte homeostasis" EXACT []
synonym: "B-1 B-cell homeostasis" EXACT []
synonym: "B-1 B-lymphocyte homeostasis" EXACT []
is_a: GO:0001782 ! B cell homeostasis

[Term]
id: GO:0001923
name: B-1 B cell differentiation
namespace: biological_process
def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
synonym: "B-1 B cell development" RELATED [GOC:add]
synonym: "B-1 B lymphocyte differentiation" EXACT []
synonym: "B-1 B-cell differentiation" EXACT []
synonym: "B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0001924
name: regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "regulation of B-1 B-cell differentiation" EXACT []
synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001923 ! B-1 B cell differentiation
relationship: regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001925
name: negative regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "down regulation of B-1 B cell differentiation" EXACT []
synonym: "down-regulation of B-1 B cell differentiation" EXACT []
synonym: "downregulation of B-1 B cell differentiation" EXACT []
synonym: "inhibition of B-1 B cell differentiation" NARROW []
synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-1 B-cell differentiation" EXACT []
synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045578 ! negative regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001923 ! B-1 B cell differentiation
relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001926
name: positive regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "activation of B-1 B cell differentiation" NARROW []
synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add]
synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-1 B-cell differentiation" EXACT []
synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B-1 B cell differentiation" NARROW []
synonym: "up regulation of B-1 B cell differentiation" EXACT []
synonym: "up-regulation of B-1 B cell differentiation" EXACT []
synonym: "upregulation of B-1 B cell differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045579 ! positive regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001923 ! B-1 B cell differentiation
relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001927
name: exocyst assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis

[Term]
id: GO:0001928
name: regulation of exocyst assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0043254 ! regulation of protein complex assembly
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001927 ! exocyst assembly
relationship: regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001929
name: negative regulation of exocyst assembly
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "down regulation of exocyst assembly" EXACT []
synonym: "down-regulation of exocyst assembly" EXACT []
synonym: "downregulation of exocyst assembly" EXACT []
synonym: "inhibition of exocyst assembly" NARROW []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0048523 ! negative regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001927 ! exocyst assembly
relationship: negatively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001930
name: positive regulation of exocyst assembly
namespace: biological_process
def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "activation of exocyst assembly" NARROW []
synonym: "stimulation of exocyst assembly" NARROW []
synonym: "up regulation of exocyst assembly" EXACT []
synonym: "up-regulation of exocyst assembly" EXACT []
synonym: "upregulation of exocyst assembly" EXACT []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0048522 ! positive regulation of cellular process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001927 ! exocyst assembly
relationship: positively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001931
name: uropod
namespace: cellular_component
def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]
synonym: "distal pole complex" RELATED []
synonym: "retractile pole" RELATED []
synonym: "uropodium" EXACT []
is_a: GO:0042995 ! cell projection
intersection_of: GO:0042995 ! cell projection
intersection_of: part_of GO:0031254 ! trailing edge
relationship: part_of GO:0031254 ! trailing edge

[Term]
id: GO:0001932
name: regulation of protein phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006468 ! protein phosphorylation
relationship: regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001933
name: negative regulation of protein phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006468 ! protein phosphorylation
relationship: negatively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001934
name: positive regulation of protein phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf]
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006468 ! protein phosphorylation
relationship: positively_regulates GO:0006468 ! protein phosphorylation

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001935 ! endothelial cell proliferation
relationship: regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation
relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation
relationship: positively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001939
name: female pronucleus
namespace: cellular_component
def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph]
synonym: "postsynaptic membrane organisation" EXACT [GOC:curators]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0001942
name: hair follicle development
namespace: biological_process
alt_id: GO:0001943
def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073]
is_a: GO:0008544 ! epidermis development
is_a: GO:0022405 ! hair cycle process

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]
synonym: "vascular system development" RELATED [GOC:curators]
is_a: GO:0048731 ! system development
relationship: part_of GO:0072358 ! cardiovascular system development

[Term]
id: GO:0001945
name: lymph vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001946
name: lymphangiogenesis
namespace: biological_process
def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]
synonym: "lymph vessel formation" EXACT systematic_synonym []
xref: Wikipedia:Lymphangiogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0001947
name: heart looping
namespace: biological_process
def: "The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration." [GOC:dph, PMID:12094232]
synonym: "cardiac looping" EXACT []
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry

[Term]
id: GO:0001948
name: glycoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001949
name: sebaceous gland cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]
synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators]
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0001950
name: plasma membrane enriched fraction
namespace: cellular_component
def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]
synonym: "PME fraction" RELATED [GOC:mah]
is_a: GO:0000267 ! cell fraction
relationship: part_of GO:0005624 ! membrane fraction

[Term]
id: GO:0001951
name: intestinal D-glucose absorption
namespace: biological_process
def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832]
is_a: GO:0015758 ! glucose transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0001952
name: regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0007160 ! cell-matrix adhesion
relationship: regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001953
name: negative regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd]
synonym: "down regulation of cell-matrix adhesion" EXACT []
synonym: "down-regulation of cell-matrix adhesion" EXACT []
synonym: "downregulation of cell-matrix adhesion" EXACT []
synonym: "inhibition of cell-matrix adhesion" NARROW []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0007160 ! cell-matrix adhesion
relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001954
name: positive regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]
synonym: "activation of cell-matrix adhesion" NARROW []
synonym: "stimulation of cell-matrix adhesion" NARROW []
synonym: "up regulation of cell-matrix adhesion" EXACT []
synonym: "up-regulation of cell-matrix adhesion" EXACT []
synonym: "upregulation of cell-matrix adhesion" EXACT []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007160 ! cell-matrix adhesion
relationship: positively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0071695 ! anatomical structure maturation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion
relationship: positively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]
comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division.
synonym: "dermal ossification" NARROW [GO_REF:0000034]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0036072 ! direct ossification

[Term]
id: GO:0001958
name: endochondral ossification
namespace: biological_process
def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437]
xref: Wikipedia:Endochondral_ossification
is_a: GO:0036075 ! replacement ossification
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0060759 ! regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway
relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001962
name: alpha-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427]
synonym: "isoglobotriaosylceramide synthase" NARROW []
xref: EC:2.4.1.-
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph]
is_a: GO:0007270 ! neuron-neuron synaptic transmission

[Term]
id: GO:0001964
name: startle response
namespace: biological_process
def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
xref: Wikipedia:Startle_reaction
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0001965
name: G-protein alpha-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
synonym: "G-alpha protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001966
name: thigmotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph]
synonym: "stereotaxis" EXACT []
synonym: "taxis in response to mechanical stimulus" BROAD []
synonym: "taxis in response to touch stimulus" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0001967
name: suckling behavior
namespace: biological_process
def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph]
synonym: "nursing behavior" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0051705 ! behavioral interaction between organisms

[Term]
id: GO:0001968
name: fibronectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001969
name: regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "regulation of activation of MAC" EXACT [GOC:mah]
synonym: "regulation of activation of TCC" NARROW [GOC:mah]
synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "regulation of MAC assembly" EXACT [GOC:rl]
synonym: "regulation of MAC formation" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0030449 ! regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001905 ! activation of membrane attack complex
relationship: regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001970
name: positive regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "activation of activation of membrane attack complex" NARROW []
synonym: "positive regulation of activation of MAC" EXACT [GOC:mah]
synonym: "positive regulation of activation of TCC" NARROW [GOC:mah]
synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "positive regulation of MAC assembly" EXACT [GOC:rl]
synonym: "positive regulation of MAC formation" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl]
synonym: "stimulation of activation of membrane attack complex" NARROW []
synonym: "up regulation of activation of membrane attack complex" EXACT []
synonym: "up-regulation of activation of membrane attack complex" EXACT []
synonym: "upregulation of activation of membrane attack complex" EXACT []
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045917 ! positive regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001905 ! activation of membrane attack complex
relationship: positively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001971
name: negative regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "down regulation of activation of membrane attack complex" EXACT []
synonym: "down-regulation of activation of membrane attack complex" EXACT []
synonym: "downregulation of activation of membrane attack complex" EXACT []
synonym: "inhibition of activation of membrane attack complex" NARROW []
synonym: "negative regulation of activation of MAC" EXACT [GOC:mah]
synonym: "negative regulation of activation of TCC" NARROW [GOC:mah]
synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "negative regulation of MAC assembly" EXACT [GOC:rl]
synonym: "negative regulation of MAC formation" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045916 ! negative regulation of complement activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001905 ! activation of membrane attack complex
relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001972
name: retinoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd]
is_a: GO:0005501 ! retinoid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0001973
name: adenosine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]
synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289]
synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah]
synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289]
is_a: GO:0035588 ! G-protein coupled purinergic receptor signaling pathway

[Term]
id: GO:0001974
name: blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing blood vessels." [GOC:hjd]
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0001975
name: response to amphetamine
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef]
is_a: GO:0014075 ! response to amine stimulus

[Term]
id: GO:0001976
name: neurological system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050877 ! neurological system process
intersection_of: GO:0050877 ! neurological system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0001977
name: renal system process involved in regulation of blood volume
namespace: biological_process
def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "renal blood volume control of blood pressure" RELATED []
synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "baroreceptor feedback control of blood pressure" RELATED []
synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X]
synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "chemoreceptor control of blood pressure" RELATED []
synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001980
name: regulation of systemic arterial blood pressure by ischemic conditions
namespace: biological_process
def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "CNS ischemic response" RELATED [ISBN:0721643949]
synonym: "ischemic control of blood pressure" RELATED []
synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001981
name: baroreceptor detection of arterial stretch
namespace: biological_process
def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0001982
name: baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0001983
name: baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0001984
name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949]
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001985
name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949]
synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW []
synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED []
synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0010459 ! negative regulation of heart rate
intersection_of: GO:0010459 ! negative regulation of heart rate
intersection_of: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001986
name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT []
synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0045822 ! negative regulation of heart contraction
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001987
name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001988
name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED []
synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
intersection_of: GO:0010460 ! positive regulation of heart rate
intersection_of: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001989
name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]
synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED []
synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED []
synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb]
is_a: GO:0045823 ! positive regulation of heart contraction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process

[Term]
id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949]
synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT []
synonym: "circulatory renin-angiotensin control of blood pressure" RELATED []
synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT []
synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED []
synonym: "renin-angiotensin blood pressure control" RELATED []
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0001993
name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949]
synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED []
synonym: "norepinephrine-epinephrine blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0001994
name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001995
name: norepinephrine-epinephrine catabolic process in blood stream
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd]
synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT []
is_a: GO:0042419 ! epinephrine catabolic process
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0001996
name: positive regulation of heart rate by epinephrine-norepinephrine
namespace: biological_process
def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph]
synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED []
synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001997
name: positive regulation of the force of heart contraction by epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio]
synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT []
synonym: "increased inotropy by epinephrine-norepinephrine " RELATED []
synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001998
name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED []
synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT []
synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0001999
name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
namespace: biological_process
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002000
name: detection of renal blood flow
namespace: biological_process
def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949]
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002001
name: renin secretion into blood stream
namespace: biological_process
def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949]
synonym: "renin release into blood stream" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002002
name: regulation of angiotensin levels in blood
namespace: biological_process
def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph]
synonym: "control of angiotensin levels in blood" RELATED []
synonym: "control of blood angiotensin level" RELATED []
synonym: "regulation of blood angiotensin level" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0060177 ! regulation of angiotensin metabolic process
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002003
name: angiotensin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002004
name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949]
synonym: "secretion of vasopressin during fast control of blood pressure" RELATED []
synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0030103 ! vasopressin secretion
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002005
name: angiotensin catabolic process in blood
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949]
is_a: GO:0044254 ! multicellular organismal protein catabolic process
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002006
name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]
synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0010850 ! regulation of blood pressure by chemoreceptor signaling pathway
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002008
name: excitation of vasomotor center by chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT []
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0002010
name: excitation of vasomotor center by baroreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT []
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0002012
name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002013
name: detection of carbon dioxide by vasomotor center
namespace: biological_process
def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002014
name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002015
name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback
namespace: biological_process
def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb]
synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "atrial control of blood pressure" RELATED []
synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio]
synonym: "atrial reflex" RELATED [GOC:dph]
is_a: GO:0003015 ! heart process
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0002016
name: regulation of blood volume by renin-angiotensin
namespace: biological_process
def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "renin-angiotensin control of body fluid levels" RELATED []
synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0002017
name: regulation of blood volume by renal aldosterone
namespace: biological_process
def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949]
synonym: "aldosterone mediated control of body fluids" RELATED []
synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
namespace: biological_process
def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949]
synonym: "renin-angiotensin control of aldosterone production" RELATED []
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002019
name: regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]
synonym: "angiotensin mediated control of renal output" RELATED []
synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002020
name: protease binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0002021
name: response to dietary excess
namespace: biological_process
def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [PMID:12161655]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0050896 ! response to stimulus
relationship: part_of GO:0040014 ! regulation of multicellular organism growth

[Term]
id: GO:0002022
name: detection of dietary excess
namespace: biological_process
def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002023
name: reduction of food intake in response to dietary excess
namespace: biological_process
def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655]
is_a: GO:0042755 ! eating behavior
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002024
name: diet induced thermogenesis
namespace: biological_process
def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655]
is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002025
name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008]
synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0002026
name: regulation of the force of heart contraction
namespace: biological_process
def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb]
synonym: "heart inotropy" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006814 ! sodium ion transport
relationship: regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0002029
name: desensitization of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717]
synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
is_a: GO:0022401 ! negative adaptation of signaling pathway
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002030
name: inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717]
is_a: GO:0006468 ! protein phosphorylation
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002031
name: G-protein coupled receptor internalization
namespace: biological_process
def: "The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle." [PMID:8396717]
is_a: GO:0031623 ! receptor internalization
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002032
name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717]
synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway
is_a: GO:0032091 ! negative regulation of protein binding

[Term]
id: GO:0002033
name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951, PMID:10425188]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0002034
name: regulation of blood vessel size by renin-angiotensin
namespace: biological_process
def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb]
synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0002035
name: brain renin-angiotensin system
namespace: biological_process
def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002036
name: regulation of L-glutamate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051955 ! regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0015813 ! L-glutamate transport
relationship: regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002037
name: negative regulation of L-glutamate transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "down regulation of L-glutamate transport" EXACT []
synonym: "down-regulation of L-glutamate transport" EXACT []
synonym: "downregulation of L-glutamate transport" EXACT []
synonym: "inhibition of L-glutamate transport" NARROW []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0051956 ! negative regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0015813 ! L-glutamate transport
relationship: negatively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002038
name: positive regulation of L-glutamate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "upregulation of L-glutamate transport" EXACT []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051957 ! positive regulation of amino acid transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0015813 ! L-glutamate transport
relationship: positively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002039
name: p53 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002040
name: sprouting angiogenesis
namespace: biological_process
def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002041
name: intussusceptive angiogenesis
namespace: biological_process
def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002042
name: cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0002040 ! sprouting angiogenesis
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002043
name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003]
synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001935 ! endothelial cell proliferation
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002044
name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
intersection_of: GO:0043534 ! blood vessel endothelial cell migration
intersection_of: part_of GO:0002041 ! intussusceptive angiogenesis
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002045
name: regulation of cell adhesion involved in intussusceptive angiogenesis
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0030155 ! regulation of cell adhesion
intersection_of: part_of GO:0002041 ! intussusceptive angiogenesis
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002046
name: opsin binding
namespace: molecular_function
alt_id: GO:0016030
def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd]
synonym: "metarhodopsin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002047
name: phenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph]
subset: gosubset_prok
synonym: "acridizine biosynthesis" RELATED []
synonym: "acridizine biosynthetic process" RELATED []
synonym: "azophenylene biosynthesis" RELATED []
synonym: "azophenylene biosynthetic process" RELATED []
synonym: "dibenzo-p-diazine biosynthesis" RELATED []
synonym: "dibenzo-p-diazine biosynthetic process" RELATED []
synonym: "dibenzopyrazine biosynthesis" RELATED []
synonym: "dibenzopyrazine biosynthetic process" RELATED []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0002048
name: pyoverdine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763]
synonym: "pyoverdine metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0002049
name: pyoverdine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0002050
name: pyoverdine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0002051
name: osteoblast fate commitment
namespace: biological_process
def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation
relationship: positively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation
relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0036094 ! small molecule binding

[Term]
id: GO:0002055
name: adenine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd]
synonym: "6-aminopurine binding" EXACT []
is_a: GO:0002060 ! purine base binding

[Term]
id: GO:0002056
name: cytosine binding
namespace: molecular_function
def: "Interactiing selectively with cytosine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine base binding

[Term]
id: GO:0002057
name: guanine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanine." [GOC:hjd]
is_a: GO:0002060 ! purine base binding

[Term]
id: GO:0002058
name: uracil binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with uracil." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine base binding

[Term]
id: GO:0002059
name: thymine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thymine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine base binding

[Term]
id: GO:0002060
name: purine base binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine base, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd]
synonym: "purine binding" RELATED [GOC:curators]
synonym: "purine nucleobase binding" EXACT [CHEBI:26386]
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002061
name: pyrimidine base binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine base, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd]
synonym: "1,3-diazine binding" NARROW []
synonym: "pyrimidine binding" RELATED [GOC:curators]
synonym: "pyrimidine nucleobase binding" EXACT [CHEBI:26432]
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0002068 ! glandular epithelial cell development

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0002074
name: extraocular skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002075
name: somitomeric trunk muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0002076
name: osteoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002077
name: acrosome matrix dispersal
namespace: biological_process
def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029]
is_a: GO:0048610 ! cellular process involved in reproduction
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002078
name: membrane fusion involved in acrosome reaction
namespace: biological_process
def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029]
synonym: "membrane fusion involved in the acrosomal reaction" EXACT []
is_a: GO:0006944 ! cellular membrane fusion
is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism
intersection_of: GO:0061025 ! membrane fusion
intersection_of: part_of GO:0007340 ! acrosome reaction
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044425 ! membrane part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044425 ! membrane part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002082
name: regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006119 ! oxidative phosphorylation
relationship: regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0002083
name: 4-hydroxybenzoate decaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230]
xref: EC:2.5.1.39
xref: MetaCyc:RXN-9230
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0002084
name: protein depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
is_a: GO:0035601 ! protein deacylation
is_a: GO:0042159 ! lipoprotein catabolic process

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tairtb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation
relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0002086
name: diaphragm contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206]
is_a: GO:0003011 ! involuntary skeletal muscle contraction
is_a: GO:0003016 ! respiratory system process

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by neurological system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! neurological system process
intersection_of: GO:0050877 ! neurological system process
intersection_of: results_in GO:0043576 ! regulation of respiratory gaseous exchange

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0002090
name: regulation of receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
is_a: GO:0060255 ! regulation of macromolecule metabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0031623 ! receptor internalization
relationship: regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002091
name: negative regulation of receptor internalization
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "down regulation of receptor internalization" EXACT []
synonym: "down-regulation of receptor internalization" EXACT []
synonym: "downregulation of receptor internalization" EXACT []
synonym: "inhibition of receptor internalization" NARROW []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0031623 ! receptor internalization
relationship: negatively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002092
name: positive regulation of receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "activation of receptor internalization" NARROW []
synonym: "stimulation of receptor internalization" NARROW []
synonym: "up regulation of receptor internalization" EXACT []
synonym: "up-regulation of receptor internalization" EXACT []
synonym: "upregulation of receptor internalization" EXACT []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0031623 ! receptor internalization
relationship: positively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002093
name: auditory receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb]
synonym: "hair cell morphogenesis" BROAD [GO:dph]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060117 ! auditory receptor cell development

[Term]
id: GO:0002094
name: polyprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0002095
name: caveolar macromolecular signaling complex
namespace: cellular_component
def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270]
synonym: "caveolar macromolecular signalling complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0002096
name: polkadots
namespace: cellular_component
def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340]
comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0002097
name: tRNA wobble base modification
namespace: biological_process
def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0002098
name: tRNA wobble uridine modification
namespace: biological_process
def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002099
name: tRNA wobble guanine modification
namespace: biological_process
def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002100
name: tRNA wobble adenosine to inosine editing
namespace: biological_process
def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002101
name: tRNA wobble cytosine modification
namespace: biological_process
def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002102
name: podosome
namespace: cellular_component
def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
xref: Wikipedia:Podosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0002103
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing

[Term]
id: GO:0002104
name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002105
name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002106
name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002107
name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
namespace: biological_process
def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]
is_a: GO:0000481 ! maturation of 5S rRNA
is_a: GO:0031125 ! rRNA 3'-end processing

[Term]
id: GO:0002108
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0002109
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0002110
name: cotranscriptional mitochondrial rRNA nucleotide insertion
namespace: biological_process
def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0002111
name: BRCA2-BRAF35 complex
namespace: cellular_component
def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0002112
name: interleukin-33 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd]
synonym: "IL-33" NARROW [GOC:mah]
synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0002113
name: interleukin-33 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd]
synonym: "IL-33 binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0002114
name: interleukin-33 receptor activity
namespace: molecular_function
def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
synonym: "IL-33 receptor activity" EXACT [GOC:mah]
synonym: "IL-33R" EXACT [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity
relationship: has_part GO:0002113 ! interleukin-33 binding

[Term]
id: GO:0002115
name: store-operated calcium entry
namespace: biological_process
def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
synonym: "calcium ion import" BROAD []
synonym: "capacitative calcium entry" EXACT []
synonym: "SOCE" EXACT []
synonym: "store-operated calcium import" EXACT []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0002116
name: semaphorin receptor complex
namespace: cellular_component
def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]
synonym: "plexin-neurophilin complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0002117
name: amphibian larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002118
name: aggressive behavior
namespace: biological_process
def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
synonym: "aggression" EXACT []
xref: Wikipedia:Aggression
is_a: GO:0051705 ! behavioral interaction between organisms

[Term]
id: GO:0002119
name: nematode larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002120
name: predatory behavior
namespace: biological_process
def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd]
synonym: "predatory aggression" EXACT []
synonym: "predatory aggressive behavior" EXACT []
is_a: GO:0002118 ! aggressive behavior
is_a: GO:0044366 ! feeding on or from other organism

[Term]
id: GO:0002121
name: inter-male aggressive behavior
namespace: biological_process
def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
synonym: "inter-male aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002122
name: fear-induced aggressive behavior
namespace: biological_process
def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd]
synonym: "fear-induced aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002123
name: irritable aggressive behavior
namespace: biological_process
def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd]
synonym: "irritable aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002124
name: territorial aggressive behavior
namespace: biological_process
def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd]
synonym: "territorial aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002125
name: maternal aggressive behavior
namespace: biological_process
def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd]
comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
synonym: "maternal aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002126
name: instrumental aggressive behavior
namespace: biological_process
def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd]
synonym: "instrumental aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002127
name: wobble base cytosine methylation
namespace: biological_process
def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X]
synonym: "wobble position m5C biosynthesis" EXACT []
is_a: GO:0002101 ! tRNA wobble cytosine modification
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002128
name: tRNA nucleoside ribose methylation
namespace: biological_process
def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002129
name: wobble position guanine ribose methylation
namespace: biological_process
def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002130
name: wobble position ribose methylation
namespace: biological_process
def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation

[Term]
id: GO:0002131
name: wobble position cytosine ribose methylation
namespace: biological_process
def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002132
name: wobble position uridine ribose methylation
namespace: biological_process
def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002133
name: polycystin complex
namespace: cellular_component
def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144]
comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0002134
name: UTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding

[Term]
id: GO:0002135
name: CTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding

[Term]
id: GO:0002136
name: wobble base lysidine biosynthesis
namespace: biological_process
def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617]
comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
is_a: GO:0002101 ! tRNA wobble cytosine modification

[Term]
id: GO:0002137
name: nuclear cluster
namespace: cellular_component
def: "Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1)." [PMID:9413993]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0031618 ! nuclear centromeric heterochromatin
created_by: hjd
creation_date: 2009-04-22T12:51:32Z

[Term]
id: GO:0002138
name: retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd]
synonym: "retinoic acid anabolic process" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
created_by: hjd
creation_date: 2009-05-01T10:53:24Z

[Term]
id: GO:0002139
name: stereocilia coupling link
namespace: cellular_component
def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142]
is_a: GO:0044464 ! cell part
created_by: hjd
creation_date: 2009-05-06T10:25:38Z

[Term]
id: GO:0002140
name: stereocilia tip link
namespace: cellular_component
def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787]
is_a: GO:0002139 ! stereocilia coupling link
created_by: hjd
creation_date: 2009-05-06T10:28:10Z

[Term]
id: GO:0002141
name: stereocilia ankle link
namespace: cellular_component
def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809]
is_a: GO:0002139 ! stereocilia coupling link
created_by: hjd
creation_date: 2009-05-06T10:31:56Z

[Term]
id: GO:0002142
name: stereocilia ankle link complex
namespace: cellular_component
def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0002141 ! stereocilia ankle link
created_by: hjd
creation_date: 2009-05-06T10:33:57Z

[Term]
id: GO:0002143
name: tRNA wobble position uridine thiolation
namespace: biological_process
def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]
comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah]
synonym: "wobble position s2U biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0034227 ! tRNA thio-modification
created_by: hjd
creation_date: 2009-05-06T05:05:40Z

[Term]
id: GO:0002144
name: cytosolic tRNA wobble base thiouridylase complex
namespace: cellular_component
def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219]
synonym: "Cut1-Cut2 complex" NARROW []
synonym: "tRNA thiouridylase" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part
created_by: hjd
creation_date: 2009-05-08T02:32:55Z

[Term]
id: GO:0002145
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543]
synonym: "HMP-PP diphosphatase" EXACT []
synonym: "HMP-PP pyrophosphatase" EXACT []
xref: MetaCyc:RXN0-3543
is_a: GO:0016462 ! pyrophosphatase activity
created_by: hjd
creation_date: 2009-06-10T11:21:35Z

[Term]
id: GO:0002146
name: steroid hormone receptor import into nucleus
namespace: biological_process
def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd]
comment: Note that 'translocation' is sometimes used in the literature to refer to the entire process of protein import into the nucleus, but in GO refers specifically to the step in which a cargo-carrier protein complex moves through the nuclear pore complex.
synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah]
is_a: GO:0006606 ! protein import into nucleus
created_by: hjd
creation_date: 2009-07-09T02:34:42Z

[Term]
id: GO:0002147
name: glucocorticoid receptor import into nucleus
namespace: biological_process
def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd]
synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah]
is_a: GO:0002146 ! steroid hormone receptor import into nucleus
relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway
created_by: hjd
creation_date: 2009-07-09T02:36:09Z

[Term]
id: GO:0002148
name: hypochlorous acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024]
synonym: "HClO metabolic process" EXACT []
synonym: "HOCl metabolic process" EXACT []
synonym: "hypochlorite metabolic process" RELATED []
synonym: "hypochlorous acid metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process
created_by: hjd
creation_date: 2009-10-13T10:27:48Z

[Term]
id: GO:0002149
name: hypochlorous acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]
comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
synonym: "HClO biosynthetic process" EXACT []
synonym: "HOCl biosynthetic process" EXACT []
synonym: "hypochlorite biosynthetic process" RELATED []
synonym: "hypochlorous acid biosynthesis" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process
created_by: hjd
creation_date: 2009-10-13T10:32:35Z

[Term]
id: GO:0002150
name: hypochlorous acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add]
synonym: "HClO catabolic process" EXACT []
synonym: "HOCl catabolic process" EXACT []
synonym: "hypochlorite catabolic process" RELATED []
synonym: "hypochlorous acid catabolism" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process
is_a: GO:0044282 ! small molecule catabolic process
created_by: hjd
creation_date: 2009-10-13T10:36:09Z

[Term]
id: GO:0002151
name: G-quadruplex RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
synonym: "G quadruplex binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:hjd]
synonym: "G quartet RNA binding" EXACT [GOC:hjd]
synonym: "G-quartet binding" BROAD [GOC:mah]
is_a: GO:0003723 ! RNA binding
created_by: hjd
creation_date: 2009-10-22T01:38:02Z

[Term]
id: GO:0002152
name: bile acid conjugation
namespace: biological_process
def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413]
comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
is_a: GO:0008206 ! bile acid metabolic process
created_by: hjd
creation_date: 2009-10-29T01:41:51Z

[Term]
id: GO:0002153
name: steroid receptor RNA activator RNA binding
namespace: molecular_function
def: "Selectively interacting with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [PMID:10199399, PMID:15180993]
comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
synonym: "SRA binding" EXACT []
is_a: GO:0003727 ! single-stranded RNA binding
created_by: hjd
creation_date: 2009-11-16T02:18:55Z

[Term]
id: GO:0002154
name: thyroid hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd]
synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0030522 ! intracellular receptor mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:36:29Z

[Term]
id: GO:0002155
name: regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:37:46Z

[Term]
id: GO:0002156
name: negative regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:41:48Z

[Term]
id: GO:0002157
name: positive regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway
created_by: hjd
creation_date: 2009-11-19T12:42:57Z

[Term]
id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation
created_by: hjd
creation_date: 2010-02-03T01:50:37Z

[Term]
id: GO:0002159
name: desmosome assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0007043 ! cell-cell junction assembly
created_by: hjd
creation_date: 2010-02-09T10:46:30Z

[Term]
id: GO:0002160
name: desmosome maintenance
namespace: biological_process
def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0002934 ! desmosome organization
is_a: GO:0045217 ! cell-cell junction maintenance
created_by: hjd
creation_date: 2010-02-09T10:50:59Z

[Term]
id: GO:0002161
name: aminoacyl-tRNA editing activity
namespace: molecular_function
def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889]
synonym: "amino acid proofreading activity" RELATED []
synonym: "aminoacyl-tRNA hydrolysis activity" RELATED []
is_a: GO:0052689 ! carboxylic ester hydrolase activity
relationship: part_of GO:0006450 ! regulation of translational fidelity
created_by: hjd
creation_date: 2010-02-12T03:06:56Z

[Term]
id: GO:0002162
name: dystroglycan binding
namespace: molecular_function
alt_id: GO:0002163
alt_id: GO:0002166
def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd]
synonym: "alpha-dystroglycan binding" NARROW []
synonym: "beta-dystroglycan binding" NARROW []
is_a: GO:0001948 ! glycoprotein binding
created_by: hjd
creation_date: 2010-02-22T02:17:58Z

[Term]
id: GO:0002164
name: larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002165
name: instar larval or pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002167
name: VRK3/VHR/ERK complex
namespace: cellular_component
def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2010-03-04T01:15:05Z

[Term]
id: GO:0002168
name: instar larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002164 ! larval development
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0002169
name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
namespace: cellular_component
def: "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465]
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
created_by: hjd
creation_date: 2010-03-15T04:58:08Z

[Term]
id: GO:0002170
name: high affinity IgA receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
is_a: GO:0019766 ! IgA receptor activity
created_by: hjd
creation_date: 2010-05-06T05:00:11Z

[Term]
id: GO:0002171
name: low affinity IgA receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
is_a: GO:0019766 ! IgA receptor activity
created_by: hjd
creation_date: 2010-05-06T05:01:41Z

[Term]
id: GO:0002172
name: high affinity IgM receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
is_a: GO:0001793 ! IgM receptor activity
created_by: hjd
creation_date: 2010-05-06T05:03:26Z

[Term]
id: GO:0002173
name: low affinity IgM receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]
is_a: GO:0001793 ! IgM receptor activity
created_by: hjd
creation_date: 2010-05-06T05:04:24Z

[Term]
id: GO:0002174
name: mammary stem cell proliferation
namespace: biological_process
def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030879 ! mammary gland development
created_by: hjd
creation_date: 2010-09-14T01:19:45Z

[Term]
id: GO:0002175
name: protein localization to paranode region of axon
namespace: biological_process
def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321]
synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization
created_by: hjd
creation_date: 2010-11-15T10:28:20Z

[Term]
id: GO:0002176
name: male germ cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]
is_a: GO:0036093 ! germ cell proliferation
created_by: hjd
creation_date: 2010-11-18T02:35:14Z

[Term]
id: GO:0002177
name: manchette
namespace: cellular_component
def: "A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation." [PMID:15018141]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton
created_by: hjd
creation_date: 2010-12-01T02:31:43Z

[Term]
id: GO:0002178
name: palmitoyltransferase complex
namespace: cellular_component
def: "A protein complex with palmitoyltransferase activity." [GOC:hjd]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2010-12-03T10:49:17Z

[Term]
id: GO:0002179
name: homodimeric serine palmitoyltransferase complex
namespace: cellular_component
def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd]
comment: This complex occurs primarily in bacteria.
is_a: GO:0002178 ! palmitoyltransferase complex
created_by: hjd
creation_date: 2010-12-03T10:50:59Z

[Term]
id: GO:0002180
name: 5-lipoxygenase complex
namespace: cellular_component
def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240]
is_a: GO:0043234 ! protein complex
is_a: GO:0044453 ! nuclear membrane part
created_by: hjd
creation_date: 2011-06-09T01:05:53Z

[Term]
id: GO:0002181
name: cytoplasmic translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]
subset: goslim_pombe
subset: goslim_yeast
is_a: GO:0006412 ! translation
created_by: hjd
creation_date: 2011-06-09T03:11:53Z

[Term]
id: GO:0002182
name: cytoplasmic translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]
is_a: GO:0006414 ! translational elongation
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:14:42Z

[Term]
id: GO:0002183
name: cytoplasmic translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]
is_a: GO:0006413 ! translational initiation
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:15:48Z

[Term]
id: GO:0002184
name: cytoplasmic translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]
is_a: GO:0006415 ! translational termination
relationship: part_of GO:0002181 ! cytoplasmic translation
created_by: hjd
creation_date: 2011-06-09T03:17:13Z

[Term]
id: GO:0002185
name: creatine kinase complex
namespace: cellular_component
def: "A protein complex having creatine kinase activity." [GOC:hjd]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2011-06-14T02:12:19Z

[Term]
id: GO:0002186
name: cytosolic creatine kinase complex
namespace: cellular_component
def: "A dimeric protein complex having creatine kinase activity." [PMID:173175]
is_a: GO:0002185 ! creatine kinase complex
is_a: GO:0044445 ! cytosolic part
created_by: hjd
creation_date: 2011-06-14T02:14:16Z

[Term]
id: GO:0002187
name: mitochondrial creatine kinase complex
namespace: cellular_component
def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486]
is_a: GO:0002185 ! creatine kinase complex
is_a: GO:0044429 ! mitochondrial part
created_by: hjd
creation_date: 2011-06-14T02:15:29Z

[Term]
id: GO:0002188
name: translation reinitiation
namespace: biological_process
def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-06-22T12:31:13Z

[Term]
id: GO:0002189
name: ribose phosphate diphosphokinase complex
namespace: cellular_component
def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095]
comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits.
synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095]
synonym: "PRPP synthetase complex" EXACT [PMID:9348095]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2011-06-27T02:49:33Z

[Term]
id: GO:0002190
name: cap-independent translational initiation
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-08-11T02:16:05Z

[Term]
id: GO:0002191
name: cap-dependent translational initiation
namespace: biological_process
def: "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130]
is_a: GO:0002183 ! cytoplasmic translational initiation
created_by: hjd
creation_date: 2011-08-11T02:20:24Z

[Term]
id: GO:0002192
name: IRES-dependent translational initiation
namespace: biological_process
def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]
is_a: GO:0002190 ! cap-independent translational initiation
created_by: hjd
creation_date: 2011-08-11T02:32:45Z

[Term]
id: GO:0002193
name: MAML1-RBP-Jkappa- ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]
synonym: "MAML1-CSL-ICN1" EXACT []
synonym: "MAML1-CSL-Notch1 complex" EXACT []
synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT []
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2011-08-11T04:08:18Z

[Term]
id: GO:0002194
name: hepatocyte cell migration
namespace: biological_process
def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819]
is_a: GO:0016477 ! cell migration
created_by: hjd
creation_date: 2011-08-30T04:27:39Z

[Term]
id: GO:0002195
name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
namespace: biological_process
def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729]
comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli.
is_a: GO:0006400 ! tRNA modification
created_by: hjd
creation_date: 2011-08-31T02:20:06Z

[Term]
id: GO:0002196
name: Ser-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375]
is_a: GO:0002161 ! aminoacyl-tRNA editing activity
created_by: hjd
creation_date: 2011-09-30T02:18:50Z

[Term]
id: GO:0002197
name: xanthine dehydrogenase complex
namespace: cellular_component
def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915]
is_a: GO:0043234 ! protein complex
created_by: hjd
creation_date: 2011-10-03T03:55:57Z

[Term]
id: GO:0002198
name: S/G2 transition of mitotic cell cycle
namespace: biological_process
def: "The transition from a cell in the S phase to the G2 phase." [GOC:hjd, PMID:15161931]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle
created_by: hjd
creation_date: 2011-11-02T10:36:58Z

[Term]
id: GO:0002199
name: sperm protein complex
namespace: cellular_component
def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0005832 ! chaperonin-containing T-complex
created_by: hjd
creation_date: 2011-12-23T01:33:23Z

[Term]
id: GO:0002200
name: somatic diversification of immune receptors
namespace: biological_process
def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002201
name: somatic diversification of DSCAM-based immune receptors
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174]
comment: Note that this type of immune receptor may not be limited to insects.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002202
name: somatic diversification of variable lymphocyte receptors of jawless fish
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579]
comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002203
name: proteolysis by cytosolic proteases associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of antibody genes during immune response" RELATED []
synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002205
name: somatic hypermutation of immunoglobulin genes involved in immune response
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701]
synonym: "somatic hypermutation of antibody genes during immune response" RELATED []
synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response
is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: part_of GO:0002344 ! B cell affinity maturation

[Term]
id: GO:0002206
name: gene conversion of immunoglobulin genes
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes" EXACT []
is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion
is_a: GO:0016445 ! somatic diversification of immunoglobulins
is_a: GO:0035822 ! gene conversion

[Term]
id: GO:0002207
name: gene conversion of immunoglobulin genes involved in immune response
namespace: biological_process
def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes during immune response" RELATED []
synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph]
is_a: GO:0002206 ! gene conversion of immunoglobulin genes
is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response

[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701]
synonym: "somatic diversification of antibodies during immune response" RELATED []
synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph]
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002209
name: behavioral defense response
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural defense response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0007610 ! behavior

[Term]
id: GO:0002210
name: behavioral response to wounding
namespace: biological_process
def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural response to wounding" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0002211
name: behavioral defense response to insect
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "behavioural defense response to insect" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002213 ! defense response to insect

[Term]
id: GO:0002212
name: behavioral defense response to nematode
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883]
synonym: "behavioural defense response to nematode" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002215 ! defense response to nematode

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009625 ! response to insect

[Term]
id: GO:0002215
name: defense response to nematode
namespace: biological_process
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009624 ! response to nematode

[Term]
id: GO:0002218
name: activation of innate immune response
namespace: biological_process
alt_id: GO:0002219
def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]
comment: This term was added by GO_REF:0000022.
xref: Reactome:REACT_75835 "RLR (RIG-like receptor) mediated induction of IFN alpha/beta, Gallus gallus"
is_a: GO:0002253 ! activation of immune response
is_a: GO:0045089 ! positive regulation of innate immune response

[Term]
id: GO:0002220
name: innate immune response activating cell surface receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT []
synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway
is_a: GO:0002758 ! innate immune response-activating signal transduction

[Term]
id: GO:0002221
name: pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447]
is_a: GO:0002758 ! innate immune response-activating signal transduction

[Term]
id: GO:0002222
name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002223
name: stimulatory C-type lectin receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT []
synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002224
name: toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
synonym: "TLR signaling pathway" EXACT [ISBN:0781735149]
synonym: "toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_25035 "Innate immune response mediated by toll like receptors, Gallus gallus"
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002225
name: positive regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]
synonym: "activation of antimicrobial peptide production" NARROW []
synonym: "antimicrobial peptide induction" EXACT []
synonym: "stimulation of antimicrobial peptide production" NARROW []
synonym: "up regulation of antimicrobial peptide production" EXACT []
synonym: "up-regulation of antimicrobial peptide production" EXACT []
synonym: "upregulation of antimicrobial peptide production" EXACT []
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002775 ! antimicrobial peptide production
relationship: positively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002228
name: natural killer cell mediated immunity
namespace: biological_process
def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "NK cell mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002229
name: defense response to oomycetes
namespace: biological_process
def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002230
name: positive regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "activation of antiviral response by host" NARROW []
synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of antiviral response by host" NARROW []
synonym: "up regulation of antiviral response by host" EXACT []
synonym: "up-regulation of antiviral response by host" EXACT []
synonym: "upregulation of antiviral response by host" EXACT []
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0002231
name: detection of oomycetes
namespace: biological_process
def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during inflammatory response" RELATED []
synonym: "leucocyte chemotaxis during inflammatory response" RELATED []
synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph]
is_a: GO:0002523 ! leukocyte migration involved in inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002233
name: leukocyte chemotaxis involved in immune response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration involved in immune response
is_a: GO:0030595 ! leukocyte chemotaxis
intersection_of: GO:0030595 ! leukocyte chemotaxis
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002234
name: detection of endoplasmic reticulum overloading
namespace: biological_process
def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516]
synonym: "detection of ER overloading" EXACT []
is_a: GO:0006983 ! ER overload response
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002235
name: detection of unfolded protein
namespace: biological_process
def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470]
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0002236
name: detection of misfolded protein
namespace: biological_process
def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051788 ! response to misfolded protein

[Term]
id: GO:0002237
name: response to molecule of bacterial origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]
synonym: "response to bacteria associated molecule" EXACT []
synonym: "response to bacterial associated molecule" EXACT []
synonym: "response to bacterium associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0010033 ! response to organic substance
relationship: part_of GO:0009617 ! response to bacterium

[Term]
id: GO:0002238
name: response to molecule of fungal origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm]
synonym: "response to fungus associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0010033 ! response to organic substance
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0002239
name: response to oomycetes
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0002240
name: response to molecule of oomycetes origin
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm]
synonym: "response to oomycetes associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
relationship: part_of GO:0002239 ! response to oomycetes

[Term]
id: GO:0002241
name: response to parasitic plant
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0002242
name: defense response to parasitic plant
namespace: biological_process
def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002243
name: detection of parasitic plant
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0009602 ! detection of symbiont

[Term]
id: GO:0002244
name: hemopoietic progenitor cell differentiation
namespace: biological_process
def: "The process in which precursor cell type acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, ISBN:0781735149, PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hematopoietic progenitor cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002246
name: wound healing involved in inflammatory response
namespace: biological_process
def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "healing during inflammatory response" RELATED [GOC:dph]
synonym: "inflammatory response wound healing" RELATED [GOC:dph]
is_a: GO:0042060 ! wound healing
intersection_of: GO:0042060 ! wound healing
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002247
name: clearance of damaged tissue involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002248
name: connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph]
synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! wound healing involved in inflammatory response

[Term]
id: GO:0002249
name: lymphocyte anergy
namespace: biological_process
def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "acquired immune response" EXACT [ISBN:068340007X]
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002253
name: activation of immune response
namespace: biological_process
def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002254
name: kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002526 ! acute inflammatory response
is_a: GO:0072376 ! protein activation cascade

[Term]
id: GO:0002255
name: tissue kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145]
synonym: "glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002256
name: regulation of kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:2000257 ! regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002254 ! kinin cascade
relationship: regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002257
name: negative regulation of kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "down regulation of kinin cascade" EXACT []
synonym: "down-regulation of kinin cascade" EXACT []
synonym: "downregulation of kinin cascade" EXACT []
synonym: "inhibition of kinin cascade" NARROW []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:2000258 ! negative regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002254 ! kinin cascade
relationship: negatively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002258
name: positive regulation of kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "activation of kinin cascade" NARROW []
synonym: "stimulation of kinin cascade" NARROW []
synonym: "up regulation of kinin cascade" EXACT []
synonym: "up-regulation of kinin cascade" EXACT []
synonym: "upregulation of kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:2000259 ! positive regulation of protein activation cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002254 ! kinin cascade
relationship: positively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002259
name: endothelial cell activation within high endothelial venule involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb]
is_a: GO:0002264 ! endothelial cell activation involved in immune response

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0002261
name: mucosal lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020]
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001775 ! cell activation
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0001775 ! cell activation
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "endothelial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0042118 ! endothelial cell activation
intersection_of: GO:0042118 ! endothelial cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002265
name: astrocyte activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
synonym: "astrocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0048143 ! astrocyte activation
intersection_of: GO:0048143 ! astrocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002266
name: follicular dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0002267
name: follicular dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789]
synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0002266 ! follicular dendritic cell activation
intersection_of: GO:0002266 ! follicular dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002268
name: follicular dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002266 ! follicular dendritic cell activation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during inflammatory response" RELATED []
synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb]
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002270
name: plasmacytoid dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002271
name: plasmacytoid dendritic cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109]
synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002366 ! leukocyte activation involved in immune response
intersection_of: GO:0002270 ! plasmacytoid dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002272
name: plasmacytoid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333]
synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph]
is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response
is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation
intersection_of: GO:0002273 ! plasmacytoid dendritic cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002273
name: plasmacytoid dendritic cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002521 ! leukocyte differentiation

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002275
name: myeloid cell activation involved in immune response
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation involved in immune response

[Term]
id: GO:0002276
name: basophil activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "basophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0045575 ! basophil activation
intersection_of: GO:0045575 ! basophil activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation involved in immune response
intersection_of: GO:0001773 ! myeloid dendritic cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002278
name: eosinophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "eosinophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0043307 ! eosinophil activation
intersection_of: GO:0043307 ! eosinophil activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002279
name: mast cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "mast cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0045576 ! mast cell activation
intersection_of: GO:0045576 ! mast cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002280
name: monocyte activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]
synonym: "monocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042117 ! monocyte activation
intersection_of: GO:0042117 ! monocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002281
name: macrophage activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "macrophage activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042116 ! macrophage activation
intersection_of: GO:0042116 ! macrophage activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002282
name: microglial cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "microglial cell activation during immune response" RELATED [GOC:tb]
is_a: GO:0001774 ! microglial cell activation
is_a: GO:0002281 ! macrophage activation involved in immune response
intersection_of: GO:0001774 ! microglial cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002283
name: neutrophil activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "neutrophil activation during immune response" RELATED [GOC:tb]
is_a: GO:0002275 ! myeloid cell activation involved in immune response
is_a: GO:0042119 ! neutrophil activation
intersection_of: GO:0042119 ! neutrophil activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb]
is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: GO:0043011 ! myeloid dendritic cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "lymphocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002366 ! leukocyte activation involved in immune response
is_a: GO:0046649 ! lymphocyte activation
intersection_of: GO:0046649 ! lymphocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell activation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte activation during immune response" RELATED []
synonym: "T-cell activation during immune response" RELATED []
synonym: "T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042110 ! T cell activation
intersection_of: GO:0042110 ! T cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002287
name: alpha-beta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte activation during immune response" RELATED []
synonym: "alpha-beta T-cell activation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046631 ! alpha-beta T cell activation
intersection_of: GO:0046631 ! alpha-beta T cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002288
name: NK T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte activation during immune response" RELATED []
synonym: "natural killer T-cell activation during immune response" RELATED []
synonym: "natural killer T-lymphocyte activation during immune response" RELATED []
synonym: "NK T cell activation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte activation during immune response" RELATED []
synonym: "NK T-cell activation during immune response" RELATED []
synonym: "NK T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0051132 ! NK T cell activation
intersection_of: GO:0051132 ! NK T cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002289
name: NK T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte proliferation during immune response" RELATED []
synonym: "natural killer T-cell proliferation during immune response" RELATED []
synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED []
synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK T lymphocyte proliferation during immune response" RELATED []
synonym: "NK T-cell proliferation during immune response" RELATED []
synonym: "NK T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0001866 ! NK T cell proliferation
is_a: GO:0002288 ! NK T cell activation involved in immune response
is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response
intersection_of: GO:0001866 ! NK T cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002290
name: gamma-delta T cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523]
synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte activation during immune response" RELATED []
synonym: "gamma-delta T-cell activation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0046629 ! gamma-delta T cell activation
intersection_of: GO:0046629 ! gamma-delta T cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002291
name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
is_a: GO:0002286 ! T cell activation involved in immune response

[Term]
id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T cell development involved in immune response" RELATED [GOC:add]
synonym: "T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte differentiation during immune response" RELATED []
synonym: "T-cell differentiation during immune response" RELATED []
synonym: "T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0030217 ! T cell differentiation
intersection_of: GO:0030217 ! T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002293
name: alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0046632 ! alpha-beta T cell differentiation
intersection_of: GO:0046632 ! alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002294
name: CD4-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
intersection_of: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002295
name: T-helper cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149]
synonym: "T-helper cell fate commitment" EXACT []
synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149]
synonym: "Thp lineage commitment" RELATED [ISBN:0781735149]
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0002296
name: T-helper 1 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149]
synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149]
synonym: "Th1 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0002297
name: T-helper 2 cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149]
synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149]
synonym: "Th2 fate commitment" EXACT [ISBN:0781735149]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0002298
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED []
synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response
is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
intersection_of: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002299
name: alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002300
name: CD8-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002301
name: CD4-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002302
name: CD8-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
intersection_of: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002303
name: gamma-delta T cell differentiation involved in immune response
namespace: biological_process
def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add]
synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph]
synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED []
synonym: "gamma-delta T-cell differentiation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002292 ! T cell differentiation involved in immune response
is_a: GO:0042492 ! gamma-delta T cell differentiation
intersection_of: GO:0042492 ! gamma-delta T cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002304
name: gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002305
name: CD8-positive, gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002306
name: CD4-positive gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002307
name: CD8-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002308
name: CD8-positive, alpha-beta cytotoxic T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add]
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "T lymphocyte proliferation during immune response" RELATED []
synonym: "T-cell proliferation during immune response" RELATED []
synonym: "T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002286 ! T cell activation involved in immune response
is_a: GO:0042098 ! T cell proliferation
intersection_of: GO:0042098 ! T cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002310
name: alpha-beta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED []
synonym: "alpha-beta T-cell proliferation during immune response" RELATED []
synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046633 ! alpha-beta T cell proliferation
intersection_of: GO:0046633 ! alpha-beta T cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002311
name: gamma-delta T cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add]
synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb]
synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED []
synonym: "gamma-delta T-cell proliferation during immune response" RELATED []
synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response
is_a: GO:0002309 ! T cell proliferation involved in immune response
is_a: GO:0046630 ! gamma-delta T cell proliferation
intersection_of: GO:0046630 ! gamma-delta T cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002312
name: B cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]
synonym: "B cell activation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte activation during immune response" RELATED []
synonym: "B-cell activation during immune response" RELATED []
synonym: "B-lymphocyte activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0042113 ! B cell activation
intersection_of: GO:0042113 ! B cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002313
name: mature B cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B cell development involved in immune response" RELATED [GOC:add]
synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb]
synonym: "mature B lymphocyte differentiation during immune response" RELATED []
synonym: "mature B-cell differentiation during immune response" RELATED []
synonym: "mature B-lymphocyte differentiation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0002335 ! mature B cell differentiation
intersection_of: GO:0002335 ! mature B cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002314
name: germinal center B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "germinal center B cell development" RELATED [GOC:add]
synonym: "germinal center B lymphocyte differentiation" EXACT []
synonym: "germinal center B-cell differentiation" EXACT []
synonym: "germinal center B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "marginal zone B cell development" RELATED [GOC:add]
synonym: "marginal zone B lymphocyte differentiation" EXACT []
synonym: "marginal zone B-cell differentiation" EXACT []
synonym: "marginal zone B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002316
name: follicular B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "follicular B cell development" RELATED [GOC:add]
synonym: "follicular B lymphocyte differentiation" EXACT []
synonym: "follicular B-cell differentiation" EXACT []
synonym: "follicular B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002317
name: plasma cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "plasma cell development" RELATED [GOC:add]
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hemopoietic progenitor cell differentiation

[Term]
id: GO:0002319
name: memory B cell differentiation
namespace: biological_process
def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "memory B cell development" RELATED [GOC:add]
synonym: "memory B lymphocyte differentiation" EXACT []
synonym: "memory B-cell differentiation" EXACT []
synonym: "memory B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hemopoietic progenitor cell differentiation

[Term]
id: GO:0002321
name: natural killer cell progenitor differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002322
name: B cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]
synonym: "B cell proliferation during immune response" RELATED [GOC:tb]
synonym: "B lymphocyte proliferation during immune response" RELATED []
synonym: "B-cell proliferation during immune response" RELATED []
synonym: "B-lymphocyte proliferation during immune response" RELATED []
is_a: GO:0002312 ! B cell activation involved in immune response
is_a: GO:0042100 ! B cell proliferation
intersection_of: GO:0042100 ! B cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002323
name: natural killer cell activation involved in immune response
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell activation during immune response" RELATED [GOC:tb]
synonym: "NK cell activation during immune response" RELATED []
is_a: GO:0002285 ! lymphocyte activation involved in immune response
is_a: GO:0030101 ! natural killer cell activation
intersection_of: GO:0030101 ! natural killer cell activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002324
name: natural killer cell proliferation involved in immune response
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583]
synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb]
synonym: "NK cell proliferation during immune response" RELATED []
is_a: GO:0001787 ! natural killer cell proliferation
is_a: GO:0002323 ! natural killer cell activation involved in immune response
intersection_of: GO:0001787 ! natural killer cell proliferation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002325
name: natural killer cell differentiation involved in immune response
namespace: biological_process
def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "natural killer cell development involved in immune response" RELATED [GOC:add]
synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb]
synonym: "NK cell differentiation during immune response" RELATED []
is_a: GO:0001779 ! natural killer cell differentiation
is_a: GO:0002323 ! natural killer cell activation involved in immune response
intersection_of: GO:0001779 ! natural killer cell differentiation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002326
name: B cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149]
synonym: "B lymphocyte lineage commitment" EXACT []
synonym: "B-cell lineage commitment" EXACT []
synonym: "B-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002327
name: immature B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "immature B cell development" RELATED [GOC:add]
synonym: "immature B lymphocyte differentiation" EXACT []
synonym: "immature B-cell differentiation" EXACT []
synonym: "immature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002328
name: pro-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149]
synonym: "pro-B cell development" RELATED [GOC:add]
synonym: "pro-B lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002329
name: pre-B cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "pre-B cell development" RELATED [GOC:add]
synonym: "pre-B lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002330
name: pre-B cell receptor expression
namespace: biological_process
def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149]
is_a: GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002331
name: pre-B cell allelic exclusion
namespace: biological_process
def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149]
synonym: "pre-B lymphocyte allelic exclusion" EXACT []
is_a: GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002332
name: transitional stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "transitional stage B cell development" RELATED [GOC:add]
synonym: "transitional stage B lymphocyte differentiation" EXACT []
synonym: "transitional stage B-cell differentiation" EXACT []
synonym: "transitional stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002333
name: transitional one stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T1 stage B cell differentiation" EXACT []
synonym: "transitional one stage B cell development" RELATED [GOC:add]
synonym: "transitional one stage B lymphocyte differentiation" EXACT []
synonym: "transitional one stage B-cell differentiation" EXACT []
synonym: "transitional one stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002334
name: transitional two stage B cell differentiation
namespace: biological_process
def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "T2 stage B cell differentiation" EXACT []
synonym: "transitional two stage B cell development" RELATED [GOC:add]
synonym: "transitional two stage B lymphocyte differentiation" EXACT []
synonym: "transitional two stage B-cell differentiation" EXACT []
synonym: "transitional two stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002335
name: mature B cell differentiation
namespace: biological_process
def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "mature B lymphocyte differentiation" EXACT []
synonym: "mature B-cell differentiation" EXACT []
synonym: "mature B-lymphocyte differentiation" EXACT []
synonym: "mature cell development" RELATED [GOC:add]
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002336
name: B-1 B cell lineage commitment
namespace: biological_process
def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149]
synonym: "B-1 B lymphocyte lineage commitment" EXACT []
synonym: "B-1 B-cell lineage commitment" EXACT []
synonym: "B-1 B-lymphocyte lineage commitment" EXACT []
is_a: GO:0002326 ! B cell lineage commitment
relationship: part_of GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002337
name: B-1a B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1a B cell development" RELATED [GOC:add]
synonym: "B-1a B lymphocyte differentiation" EXACT []
synonym: "B-1a B-cell differentiation" EXACT []
synonym: "B-1a B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002338
name: B-1b B cell differentiation
namespace: biological_process
def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "B-1b B cell development" RELATED [GOC:add]
synonym: "B-1b B lymphocyte differentiation" EXACT []
synonym: "B-1b B-cell differentiation" EXACT []
synonym: "B-1b B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002339
name: B cell selection
namespace: biological_process
def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]
synonym: "B lymphocyte selection" EXACT []
synonym: "B-cell selection" EXACT []
synonym: "B-lymphocyte selection" EXACT []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002340
name: central B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte selection" EXACT []
synonym: "central B-cell selection" EXACT []
synonym: "central B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002341
name: central B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte anergy" EXACT []
synonym: "central B-cell anergy" EXACT []
synonym: "central B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002342
name: central B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal]
synonym: "central B lymphocyte deletion" EXACT []
synonym: "central B-cell deletion" EXACT []
synonym: "central B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002343
name: peripheral B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte selection" EXACT []
synonym: "peripheral B-cell selection" EXACT []
synonym: "peripheral B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002344
name: B cell affinity maturation
namespace: biological_process
def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "B lymphocyte affinity maturation" EXACT []
synonym: "B-cell affinity maturation" EXACT []
synonym: "B-lymphocyte affinity maturation" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002345
name: peripheral B cell receptor editing
namespace: biological_process
def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal]
synonym: "peripheral B lymphocyte receptor editing" EXACT []
synonym: "peripheral B-cell receptor editing" EXACT []
synonym: "peripheral B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002346
name: B cell positive selection
namespace: biological_process
def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal]
synonym: "B lymphocyte positive selection" EXACT []
synonym: "B-cell positive selection" EXACT []
synonym: "B-lymphocyte positive selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002347
name: response to tumor cell
namespace: biological_process
def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002348
name: central B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "central B lymphocyte positive selection" EXACT []
synonym: "central B-cell positive selection" EXACT []
synonym: "central B-lymphocyte positive selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002349
name: histamine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "histamine production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002350
name: peripheral B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "peripheral B lymphocyte positive selection" EXACT []
synonym: "peripheral B-cell positive selection" EXACT []
synonym: "peripheral B-lymphocyte positive selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]
synonym: "serotonin production involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002352
name: B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal]
synonym: "B lymphocyte negative selection" EXACT []
synonym: "B-cell negative selection" EXACT []
synonym: "B-lymphocyte negative selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002353
name: plasma kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002354
name: central B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte negative selection" EXACT []
synonym: "central B-cell negative selection" EXACT []
synonym: "central B-lymphocyte negative selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002355
name: detection of tumor cell
namespace: biological_process
def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002356
name: peripheral B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte negative selection" EXACT []
synonym: "peripheral B-cell negative selection" EXACT []
synonym: "peripheral B-lymphocyte negative selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002357
name: defense response to tumor cell
namespace: biological_process
def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002358
name: B cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]
synonym: "B lymphocyte homeostatic proliferation" EXACT []
synonym: "B-cell homeostatic proliferation" EXACT []
synonym: "B-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002359
name: B-1 B cell proliferation
namespace: biological_process
def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal]
synonym: "B-1 B lymphocyte proliferation" EXACT []
synonym: "B-1 B-cell proliferation" EXACT []
synonym: "B-1 B-lymphocyte proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002360
name: T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte lineage commitment" EXACT []
synonym: "T-cell lineage commitment" EXACT []
synonym: "T-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002361
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002362
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
namespace: biological_process
def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002363
name: alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "alpha-beta T-cell lineage commitment" EXACT []
synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002364
name: NK T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149]
synonym: "natural killer T lymphocyte lineage commitment" EXACT []
synonym: "natural killer T-cell lineage commitment" EXACT []
synonym: "natural killer T-lymphocyte lineage commitment" EXACT []
synonym: "NK T lymphocyte lineage commitment" EXACT []
synonym: "NK T-cell lineage commitment" EXACT []
synonym: "NK T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0002365
name: gamma-delta T cell lineage commitment
namespace: biological_process
def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte lineage commitment" EXACT []
synonym: "gamma-delta T-cell lineage commitment" EXACT []
synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]
synonym: "immune cell activation during immune response" RELATED []
synonym: "leucocyte activation during immune response" RELATED []
synonym: "leukocyte activation during immune response" RELATED [GOC:tb]
is_a: GO:0002263 ! cell activation involved in immune response
is_a: GO:0045321 ! leukocyte activation
intersection_of: GO:0045321 ! leukocyte activation
intersection_of: part_of GO:0006955 ! immune response

[Term]
id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
synonym: "cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002368
name: B cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149]
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production involved in immune response
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002371 ! dendritic cell cytokine production
is_a: GO:0061082 ! myeloid leukocyte cytokine production

[Term]
id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149]
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002374
name: cytokine secretion involved in immune response
namespace: biological_process
def: "The regulated release of cytokines from a cell or group of cells that contributes to an immune response." [GOC:add, ISBN:0781735149]
synonym: "cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0050663 ! cytokine secretion
intersection_of: GO:0050663 ! cytokine secretion
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002375
name: cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149]
synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0042089 ! cytokine biosynthetic process
intersection_of: GO:0042089 ! cytokine biosynthetic process
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
xref: Wikipedia:Immune_system
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0002377
name: immunoglobulin production
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "antibody production" EXACT []
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002378
name: immunoglobulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149]
synonym: "antibody biosynthesis" EXACT []
synonym: "antibody biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002379
name: immunoglobulin biosynthetic process involved in immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149]
synonym: "antibody biosynthesis during immune response" RELATED []
synonym: "antibody biosynthetic process during immune response" RELATED []
synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002378 ! immunoglobulin biosynthetic process
intersection_of: GO:0002378 ! immunoglobulin biosynthetic process
intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002380
name: immunoglobulin secretion involved in immune response
namespace: biological_process
def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563]
synonym: "antibody secretion during immune response" RELATED []
synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph]
is_a: GO:0048305 ! immunoglobulin secretion
intersection_of: GO:0048305 ! immunoglobulin secretion
intersection_of: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response

[Term]
id: GO:0002381
name: immunoglobulin production involved in immunoglobulin mediated immune response
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "antibody production during immune response" RELATED []
synonym: "immunoglobulin production during immune response" RELATED [GOC:dph]
synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph]
is_a: GO:0002377 ! immunoglobulin production
intersection_of: GO:0002377 ! immunoglobulin production
intersection_of: part_of GO:0016064 ! immunoglobulin mediated immune response
relationship: part_of GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002382
name: regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002383
name: immune response in brain or nervous system
namespace: biological_process
def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002384
name: hepatic immune response
namespace: biological_process
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002385
name: mucosal immune response
namespace: biological_process
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002386
name: immune response in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149]
synonym: "immune response in MALT" EXACT []
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149]
synonym: "immune response in GALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002388
name: immune response in Peyer's patch
namespace: biological_process
def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149]
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002389
name: tolerance induction in Peyer's patch
namespace: biological_process
def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149]
is_a: GO:0002388 ! immune response in Peyer's patch
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue

[Term]
id: GO:0002390
name: platelet activating factor production
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0002391
name: platelet activating factor production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "platelet activating factor production involved in acute inflammatory response" BROAD []
is_a: GO:0002390 ! platelet activating factor production
is_a: GO:0002534 ! cytokine production involved in inflammatory response
intersection_of: GO:0002390 ! platelet activating factor production
intersection_of: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002392
name: platelet activating factor secretion
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell or group of cells." [GOC:add, ISBN:0781735149]
is_a: GO:0050663 ! cytokine secretion

[Term]
id: GO:0002393
name: lysosomal enzyme production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add]
synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002394
name: tolerance induction in gut-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149]
synonym: "oral tolerance" RELATED []
synonym: "tolerance induction in GALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149]
synonym: "immune response in NALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0002397
name: MHC class I protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002398
name: MHC class Ib protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002400
name: tolerance induction in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149]
synonym: "nasal tolerance" RELATED []
synonym: "tolerance induction in NALT" EXACT []
is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002401
name: tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149]
synonym: "tolerance induction in MALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002402
name: B cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149]
synonym: "B cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002403
name: T cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002404
name: antigen sampling in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]
synonym: "antigen sampling in MALT" EXACT []
synonym: "antigen transport in MALT" RELATED []
synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002405
name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746]
synonym: "antigen sampling by dendritic cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue
relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002406
name: antigen sampling by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763]
synonym: "antigen sampling by M cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue

[Term]
id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002409
name: Langerhans cell chemotaxis
namespace: biological_process
def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]
is_a: GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:0002410
name: plasmacytoid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002411
name: T cell tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002413 ! tolerance induction to tumor cell
is_a: GO:0002424 ! T cell mediated immune response to tumor cell
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002412
name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411]
synonym: "antigen transcytosis by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT []
is_a: GO:0045056 ! transcytosis
relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue

[Term]
id: GO:0002413
name: tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add]
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002414
name: immunoglobulin transcytosis in epithelial cells
namespace: biological_process
def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
is_a: GO:0045056 ! transcytosis

[Term]
id: GO:0002415
name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
namespace: biological_process
def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]
synonym: "antibody transcytosis mediated by pIgR" EXACT []
synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002416
name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
namespace: biological_process
def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X]
synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT []
synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells

[Term]
id: GO:0002417
name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis

[Term]
id: GO:0002418
name: immune response to tumor cell
namespace: biological_process
def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002419
name: T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001913 ! T cell mediated cytotoxicity
is_a: GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002420
name: natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell
is_a: GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0002421
name: B cell antigen processing and presentation following pinocytosis
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530]
synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002422
name: immune response in urogenital tract
namespace: biological_process
def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002423
name: natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002424
name: T cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]
comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002425
name: tolerance induction in urogenital tract
namespace: biological_process
def: "Tolerance induction taking place in the urogenital tract." [GOC:jal]
is_a: GO:0002422 ! immune response in urogenital tract
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002426
name: immunoglobulin production in mucosal tissue
namespace: biological_process
def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal]
synonym: "antibody production in mucosal tissue " EXACT []
is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002427
name: mucosal tolerance induction
namespace: biological_process
def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002428
name: antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678]
synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002429
name: immune response-activating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT []
synonym: "immune response-activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002757 ! immune response-activating signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002430
name: complement receptor mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "complement receptor mediated signalling pathway" EXACT []
synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002431
name: Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT []
synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002432
name: granuloma formation
namespace: biological_process
def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002433
name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
namespace: biological_process
def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah]
synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [GO_REF:0000022]
is_a: GO:0002252 ! immune effector process
intersection_of: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway
intersection_of: part_of GO:0006909 ! phagocytosis
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0002434
name: immune complex clearance
namespace: biological_process
def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002435
name: immune complex clearance by erythrocytes
namespace: biological_process
def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352]
synonym: "immune complex clearance by RBCs" EXACT [CL:0000232]
synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002436
name: immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002437
name: inflammatory response to antigenic stimulus
namespace: biological_process
def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002438
name: acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002439
name: chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002441
name: histamine secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of histamine by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "histamine secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001821 ! histamine secretion
is_a: GO:0046879 ! hormone secretion
intersection_of: GO:0001821 ! histamine secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002349 ! histamine production involved in inflammatory response

[Term]
id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb]
synonym: "serotonin secretion involved in acute inflammatory response" BROAD []
is_a: GO:0001820 ! serotonin secretion
intersection_of: GO:0001820 ! serotonin secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002445
name: type II hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]
xref: Wikipedia:Type_II_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002446
name: neutrophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002447
name: eosinophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002448
name: mast cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002450
name: B cell antigen processing and presentation
namespace: biological_process
def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation" EXACT []
synonym: "B-cell antigen processing and presentation" EXACT []
synonym: "B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002451
name: peripheral B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte tolerance induction" EXACT []
synonym: "peripheral B-cell tolerance induction" EXACT []
synonym: "peripheral B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002514 ! B cell tolerance induction
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002452
name: B cell receptor editing
namespace: biological_process
def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte receptor editing" EXACT []
synonym: "B-cell receptor editing" EXACT []
synonym: "B-lymphocyte receptor editing" EXACT []
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002453
name: peripheral B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte anergy" EXACT []
synonym: "peripheral B-cell anergy" EXACT []
synonym: "peripheral B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002454
name: peripheral B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "peripheral B lymphocyte deletion" EXACT []
synonym: "peripheral B-cell deletion" EXACT []
synonym: "peripheral B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002455
name: humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "circulating antibody mediated immune response" EXACT []
synonym: "circulating immunoglobulin mediated immune response" EXACT []
synonym: "humoral defence mechanism" RELATED []
synonym: "humoral immune response mediated by circulating antibody" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002458
name: peripheral T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149]
synonym: "peripheral T lymphocyte tolerance induction" EXACT []
synonym: "peripheral T-cell tolerance induction" EXACT []
synonym: "peripheral T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002459
name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579]
synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT []
synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT []
synonym: "adaptive immune response in jawless fish" EXACT []
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002461
name: tolerance induction dependent upon immune response
namespace: biological_process
def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
synonym: "immune response-dependent tolerance induction" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002462
name: tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002463
name: central tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002508 ! central tolerance induction

[Term]
id: GO:0002464
name: peripheral tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002465
name: peripheral tolerance induction
namespace: biological_process
def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002466
name: peripheral tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149]
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002467
name: germinal center formation
namespace: biological_process
def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002470
name: plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002473
name: non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_110097 "Class I MHC mediated antigen processing & presentation, Sus scrofa"
xref: Reactome:REACT_114442 "Class I MHC mediated antigen processing & presentation, Xenopus tropicalis"
xref: Reactome:REACT_75820 "Class I MHC mediated antigen processing & presentation, Homo sapiens"
xref: Reactome:REACT_77569 "Class I MHC mediated antigen processing & presentation, Rattus norvegicus"
xref: Reactome:REACT_83138 "Class I MHC mediated antigen processing & presentation, Bos taurus"
xref: Reactome:REACT_84092 "Class I MHC mediated antigen processing & presentation, Taeniopygia guttata"
xref: Reactome:REACT_86224 "Class I MHC mediated antigen processing & presentation, Mus musculus"
xref: Reactome:REACT_88020 "Class I MHC mediated antigen processing & presentation, Danio rerio"
xref: Reactome:REACT_90151 "Class I MHC mediated antigen processing & presentation, Canis familiaris"
xref: Reactome:REACT_94042 "Class I MHC mediated antigen processing & presentation, Gallus gallus"
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002475
name: antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002476
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0002477
name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen
intersection_of: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
intersection_of: part_of GO:0042638 ! exogen

[Term]
id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "exogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen
intersection_of: GO:0048002 ! antigen processing and presentation of peptide antigen
intersection_of: part_of GO:0042638 ! exogen

[Term]
id: GO:0002479
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_111056 "Cross-presentation of soluble exogenous antigens (endosomes), Homo sapiens"
xref: Reactome:REACT_111174 "Cross-presentation of particulate exogenous antigens (phagosomes), Homo sapiens"
xref: Reactome:REACT_111178 "ER-Phagosome pathway, Homo sapiens"
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002480
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
xref: Reactome:REACT_111168 "Endosomal/Vacuolar pathway, Homo sapiens"
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002481
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002482
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]
synonym: "endogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002484
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002485
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002486
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002487
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002488
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002489
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002490
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]
synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002492
name: peptide antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002493
name: lipid antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0065005 ! protein-lipid complex assembly
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002494
name: lipid antigen transport
namespace: biological_process
def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002496
name: proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
intersection_of: GO:0006508 ! proteolysis
intersection_of: part_of GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002497
name: proteasomal proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0002498
name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]
synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT []
synonym: "ER proteolysis associated with antigen processing and presentation" EXACT []
synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002499
name: proteolysis within endosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: occurs_in GO:0005768 ! endosome

[Term]
id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]
synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
is_a: GO:0007039 ! vacuolar protein catabolic process
intersection_of: GO:0002496 ! proteolysis associated with antigen processing and presentation
intersection_of: occurs_in GO:0005764 ! lysosome

[Term]
id: GO:0002501
name: peptide antigen assembly with MHC protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0002396 ! MHC protein complex assembly
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002502
name: peptide antigen assembly with MHC class I protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002397 ! MHC class I protein complex assembly
relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002503
name: peptide antigen assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002505
name: antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240]
synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002506
name: polysaccharide assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240]
is_a: GO:0065006 ! protein-carbohydrate complex assembly
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002507
name: tolerance induction
namespace: biological_process
def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002508
name: central tolerance induction
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002509
name: central tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922]
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002510
name: central B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte tolerance induction" EXACT []
synonym: "central B-cell tolerance induction" EXACT []
synonym: "central B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002511
name: central B cell receptor editing
namespace: biological_process
def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte receptor editing" EXACT []
synonym: "central B-cell receptor editing" EXACT []
synonym: "central B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002512
name: central T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149]
synonym: "central T lymphocyte tolerance induction" EXACT []
synonym: "central T-cell tolerance induction" EXACT []
synonym: "central T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002513
name: tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002514
name: B cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922]
synonym: "B lymphocyte tolerance induction" EXACT []
synonym: "B-cell tolerance induction" EXACT []
synonym: "B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002515
name: B cell anergy
namespace: biological_process
def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte anergy" EXACT []
synonym: "B-cell anergy" EXACT []
synonym: "B-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002516
name: B cell deletion
namespace: biological_process
def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149]
synonym: "B lymphocyte deletion" EXACT []
synonym: "B-cell deletion" EXACT []
synonym: "B-lymphocyte deletion" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
intersection_of: GO:0001783 ! B cell apoptotic process
intersection_of: part_of GO:0002514 ! B cell tolerance induction
relationship: part_of GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002517
name: T cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]
synonym: "T lymphocyte tolerance induction" EXACT []
synonym: "T-cell tolerance induction" EXACT []
synonym: "T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002518
name: lymphocyte chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0002519
name: natural killer cell tolerance induction
namespace: biological_process
def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094]
synonym: "NK cell tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006955 ! immune response
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" RELATED []
synonym: "immune cell trafficking during inflammatory response" RELATED []
synonym: "leucocyte migration during inflammatory response" RELATED []
synonym: "leucocyte trafficking during inflammatory response" RELATED []
synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph]
synonym: "leukocyte trafficking during inflammatory response" RELATED []
is_a: GO:0050900 ! leukocyte migration
intersection_of: GO:0050900 ! leukocyte migration
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002524
name: hypersensitivity
namespace: biological_process
def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149]
synonym: "hypersensitivity response" RELATED [ISBN:0781735149]
xref: Wikipedia:Hypersensitivity
is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002525
name: acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002526
name: acute inflammatory response
namespace: biological_process
def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002527
name: vasodilation involved in acute inflammatory response
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal]
synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0042311 ! vasodilation
intersection_of: GO:0042311 ! vasodilation
intersection_of: part_of GO:0002526 ! acute inflammatory response
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002528
name: regulation of vascular permeability involved in acute inflammatory response
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal]
synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph]
is_a: GO:0043114 ! regulation of vascular permeability
intersection_of: GO:0043114 ! regulation of vascular permeability
intersection_of: part_of GO:0002526 ! acute inflammatory response
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002529
name: regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
is_a: GO:0002256 ! regulation of kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002530
name: regulation of systemic arterial blood pressure involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X]
synonym: "blood pressure regulation during acute phase response" RELATED []
synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
intersection_of: GO:0003073 ! regulation of systemic arterial blood pressure
intersection_of: part_of GO:0006953 ! acute-phase response
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002531
name: regulation of heart contraction involved in acute-phase response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430]
synonym: "regulation of cardiac contraction during acute phase response" RELATED []
synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb]
is_a: GO:0008016 ! regulation of heart contraction
intersection_of: GO:0008016 ! regulation of heart contraction
intersection_of: part_of GO:0006953 ! acute-phase response
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]
synonym: "production of cellular mediator of acute inflammation" RELATED []
synonym: "production of molecular mediator involved in acute inflammatory response" BROAD []
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002533
name: lysosomal enzyme secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of lysosomal enzymes by a cell or group of cells as part of an inflammatory response." [GOC:jal, PMID:11836514]
synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah]
synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD []
synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0033299 ! secretion of lysosomal enzymes
intersection_of: GO:0033299 ! secretion of lysosomal enzymes
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response

[Term]
id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "cytokine production involved in acute inflammatory response" BROAD []
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
intersection_of: GO:0001816 ! cytokine production
intersection_of: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002535
name: platelet activating factor secretion involved in inflammatory response
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149]
synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD []
is_a: GO:0002392 ! platelet activating factor secretion
intersection_of: GO:0002392 ! platelet activating factor secretion
intersection_of: part_of GO:0006954 ! inflammatory response
relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response

[Term]
id: GO:0002536
name: respiratory burst involved in inflammatory response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "oxidative burst during acute inflammatory response " BROAD []
synonym: "production of reactive oxygen species during acute inflammatory response" BROAD []
synonym: "respiratory burst involved in acute inflammatory response" BROAD []
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response
is_a: GO:0002679 ! respiratory burst involved in defense response
intersection_of: GO:0045730 ! respiratory burst
intersection_of: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002537
name: nitric oxide production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of nitric oxide involved in acute inflammatory response" BROAD []
synonym: "production of nitric oxide involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002538
name: arachidonic acid metabolite production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah]
synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD []
synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [GOC:curators]
is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response

[Term]
id: GO:0002539
name: prostaglandin production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "prostaglandin production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002540
name: leukotriene production involved in inflammatory response
namespace: biological_process
def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]
synonym: "leukotriene production involved in acute inflammatory response" BROAD []
is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response

[Term]
id: GO:0002541
name: activation of plasma proteins involved in acute inflammatory response
namespace: biological_process
def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149]
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002542
name: Factor XII activation
namespace: biological_process
def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871]
synonym: "Hageman factor activation" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0010954 ! positive regulation of protein processing
relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response

[Term]
id: GO:0002543
name: activation of blood coagulation via clotting cascade
namespace: biological_process
def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149]
synonym: "activation of clotting cascade" EXACT []
is_a: GO:0030194 ! positive regulation of blood coagulation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002544
name: chronic inflammatory response
namespace: biological_process
def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002545
name: chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal]
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002546
name: negative regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW []
synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002547
name: positive regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "activation of tissue kallikrein-kinin cascade" NARROW []
synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT []
synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW []
synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade
relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002549
name: negative regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002550
name: positive regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "activation of plasma kallikrein-kinin cascade" NARROW []
synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW []
synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002551
name: mast cell chemotaxis
namespace: biological_process
def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002552
name: serotonin secretion by mast cell
namespace: biological_process
def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by mast cell" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002553
name: histamine secretion by mast cell
namespace: biological_process
def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002554
name: serotonin secretion by platelet
namespace: biological_process
def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by platelet" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002555
name: histamine secretion by platelet
namespace: biological_process
def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002556
name: serotonin secretion by basophil
namespace: biological_process
def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
synonym: "serotonin release by basophil" RELATED [GOC:tb]
is_a: GO:0002442 ! serotonin secretion involved in inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002557
name: histamine secretion by basophil
namespace: biological_process
def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149]
is_a: GO:0002441 ! histamine secretion involved in inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002558
name: type I hypersensitivity mediated by mast cells
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002448 ! mast cell mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002559
name: type I hypersensitivity mediated by basophils
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]
is_a: GO:0002560 ! basophil mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002560
name: basophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002561
name: basophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149]
is_a: GO:0002276 ! basophil activation involved in immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002560 ! basophil mediated immunity

[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
namespace: biological_process
def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002563
name: somatic diversification of immune receptors via alternate splicing
namespace: biological_process
def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002564
name: alternate splicing of immunoglobulin genes
namespace: biological_process
def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563]
synonym: "alternate splicing of antibody genes" EXACT []
is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002565
name: somatic diversification of immune receptors via gene conversion
namespace: biological_process
def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
namespace: biological_process
def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002567
name: somatic diversification of FREP-based immune receptors
namespace: biological_process
def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575]
comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002568
name: somatic diversification of T cell receptor genes
namespace: biological_process
def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002569
name: somatic diversification of immune receptors by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002570
name: somatic diversification of immunoglobulin genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of antibody genes by N region addition" EXACT []
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002571
name: somatic diversification of T cell receptor genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149]
synonym: "somatic diversification of TCR genes by N region addition" EXACT []
is_a: GO:0002568 ! somatic diversification of T cell receptor genes
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]
synonym: "pro-T lymphocyte differentiation " EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002574
name: thrombocyte differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002575
name: basophil chemotaxis
namespace: biological_process
def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002576
name: platelet degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]
synonym: "platelet exocytosis" EXACT []
xref: Reactome:REACT_100828 "Platelet degranulation, Oryza sativa"
xref: Reactome:REACT_102232 "Platelet degranulation, Mus musculus"
xref: Reactome:REACT_102739 "Platelet degranulation, Rattus norvegicus"
xref: Reactome:REACT_102744 "Platelet degranulation, Sus scrofa"
xref: Reactome:REACT_104057 "Platelet degranulation, Saccharomyces cerevisiae"
xref: Reactome:REACT_104856 "Platelet degranulation, Caenorhabditis elegans"
xref: Reactome:REACT_118371 "Platelet degranulation, Escherichia coli"
xref: Reactome:REACT_29845 "Platelet degranulation, Bos taurus"
xref: Reactome:REACT_30497 "Platelet degranulation, Canis familiaris"
xref: Reactome:REACT_31557 "Platelet degranulation, Gallus gallus"
xref: Reactome:REACT_318 "Platelet degranulation, Homo sapiens"
xref: Reactome:REACT_33703 "Platelet degranulation, Schizosaccharomyces pombe"
xref: Reactome:REACT_80537 "Platelet degranulation, Drosophila melanogaster"
xref: Reactome:REACT_81075 "Platelet degranulation, Xenopus tropicalis"
xref: Reactome:REACT_81265 "Platelet degranulation, Danio rerio"
xref: Reactome:REACT_81408 "Platelet degranulation, Arabidopsis thaliana"
xref: Reactome:REACT_87179 "Platelet degranulation, Plasmodium falciparum"
xref: Reactome:REACT_97581 "Platelet degranulation, Taeniopygia guttata"
xref: Reactome:REACT_99712 "Platelet degranulation, Dictyostelium discoideum"
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019882 ! antigen processing and presentation
relationship: regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019882 ! antigen processing and presentation
relationship: positively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen
relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II
relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002589
name: regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002590
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002591
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002592
name: regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002593
name: negative regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002594
name: positive regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib
relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002595
name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002596
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002597
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002598
name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002599
name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002600
name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib
relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002601
name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002602
name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002603
name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002610
name: regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002611
name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002612
name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002471 ! monocyte antigen processing and presentation
relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002472 ! macrophage antigen processing and presentation
relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002619
name: regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002620
name: negative regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002621
name: positive regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation
relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002622
name: regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of B-cell antigen processing and presentation" EXACT []
synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002450 ! B cell antigen processing and presentation
relationship: regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of B cell antigen processing and presentation" EXACT []
synonym: "down-regulation of B cell antigen processing and presentation" EXACT []
synonym: "downregulation of B cell antigen processing and presentation" EXACT []
synonym: "inhibition of B cell antigen processing and presentation" NARROW []
synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of B-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002450 ! B cell antigen processing and presentation
relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "activation of B cell antigen processing and presentation" NARROW []
synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of B-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of B cell antigen processing and presentation" NARROW []
synonym: "up regulation of B cell antigen processing and presentation" EXACT []
synonym: "up-regulation of B cell antigen processing and presentation" EXACT []
synonym: "upregulation of B cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002450 ! B cell antigen processing and presentation
relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002457 ! T cell antigen processing and presentation
relationship: regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002457 ! T cell antigen processing and presentation
relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW []
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation
relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002631
name: regulation of granuloma formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002432 ! granuloma formation
relationship: regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002632
name: negative regulation of granuloma formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "down regulation of granuloma formation" EXACT []
synonym: "down-regulation of granuloma formation" EXACT []
synonym: "downregulation of granuloma formation" EXACT []
synonym: "inhibition of granuloma formation" NARROW []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002698 ! negative regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002432 ! granuloma formation
relationship: negatively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002633
name: positive regulation of granuloma formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "activation of granuloma formation" NARROW []
synonym: "stimulation of granuloma formation" NARROW []
synonym: "up regulation of granuloma formation" EXACT []
synonym: "up-regulation of granuloma formation" EXACT []
synonym: "upregulation of granuloma formation" EXACT []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002699 ! positive regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002432 ! granuloma formation
relationship: positively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002634
name: regulation of germinal center formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002467 ! germinal center formation
relationship: regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002635
name: negative regulation of germinal center formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "down regulation of germinal center formation" EXACT []
synonym: "down-regulation of germinal center formation" EXACT []
synonym: "downregulation of germinal center formation" EXACT []
synonym: "inhibition of germinal center formation" NARROW []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002467 ! germinal center formation
relationship: negatively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002636
name: positive regulation of germinal center formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "activation of germinal center formation" NARROW []
synonym: "stimulation of germinal center formation" NARROW []
synonym: "up regulation of germinal center formation" EXACT []
synonym: "up-regulation of germinal center formation" EXACT []
synonym: "upregulation of germinal center formation" EXACT []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002467 ! germinal center formation
relationship: positively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002637
name: regulation of immunoglobulin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002377 ! immunoglobulin production
relationship: regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002638
name: negative regulation of immunoglobulin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "down regulation of immunoglobulin production" EXACT []
synonym: "down-regulation of immunoglobulin production" EXACT []
synonym: "downregulation of immunoglobulin production" EXACT []
synonym: "inhibition of immunoglobulin production" NARROW []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002377 ! immunoglobulin production
relationship: negatively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "activation of immunoglobulin production" NARROW []
synonym: "stimulation of immunoglobulin production" NARROW []
synonym: "up regulation of immunoglobulin production" EXACT []
synonym: "up-regulation of immunoglobulin production" EXACT []
synonym: "upregulation of immunoglobulin production" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002377 ! immunoglobulin production
relationship: positively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002640
name: regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002641
name: negative regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "down regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "downregulation of immunoglobulin biosynthetic process" EXACT []
synonym: "inhibition of immunoglobulin biosynthetic process" NARROW []
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002642
name: positive regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "activation of immunoglobulin biosynthetic process" NARROW []
synonym: "stimulation of immunoglobulin biosynthetic process" NARROW []
synonym: "up regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "upregulation of immunoglobulin biosynthetic process" EXACT []
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process
relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002643
name: regulation of tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002507 ! tolerance induction
relationship: regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002644
name: negative regulation of tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "down regulation of tolerance induction" EXACT []
synonym: "down-regulation of tolerance induction" EXACT []
synonym: "downregulation of tolerance induction" EXACT []
synonym: "inhibition of tolerance induction" NARROW []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002683 ! negative regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002507 ! tolerance induction
relationship: negatively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002645
name: positive regulation of tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "activation of tolerance induction" NARROW []
synonym: "stimulation of tolerance induction" NARROW []
synonym: "up regulation of tolerance induction" EXACT []
synonym: "up-regulation of tolerance induction" EXACT []
synonym: "upregulation of tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002684 ! positive regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002507 ! tolerance induction
relationship: positively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002646
name: regulation of central tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002508 ! central tolerance induction
relationship: regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002647
name: negative regulation of central tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "down regulation of central tolerance induction" EXACT []
synonym: "down-regulation of central tolerance induction" EXACT []
synonym: "downregulation of central tolerance induction" EXACT []
synonym: "inhibition of central tolerance induction" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002508 ! central tolerance induction
relationship: negatively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002648
name: positive regulation of central tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "activation of central tolerance induction" NARROW []
synonym: "stimulation of central tolerance induction" NARROW []
synonym: "up regulation of central tolerance induction" EXACT []
synonym: "up-regulation of central tolerance induction" EXACT []
synonym: "upregulation of central tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002508 ! central tolerance induction
relationship: positively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002649
name: regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002513 ! tolerance induction to self antigen
relationship: regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002650
name: negative regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "down regulation of tolerance induction to self antigen" EXACT []
synonym: "down-regulation of tolerance induction to self antigen" EXACT []
synonym: "downregulation of tolerance induction to self antigen" EXACT []
synonym: "inhibition of tolerance induction to self antigen" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002513 ! tolerance induction to self antigen
relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002651
name: positive regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "activation of tolerance induction to self antigen" NARROW []
synonym: "stimulation of tolerance induction to self antigen" NARROW []
synonym: "up regulation of tolerance induction to self antigen" EXACT []
synonym: "up-regulation of tolerance induction to self antigen" EXACT []
synonym: "upregulation of tolerance induction to self antigen" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002513 ! tolerance induction to self antigen
relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002653
name: negative regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "down regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "downregulation of tolerance induction dependent upon immune response" EXACT []
synonym: "inhibition of tolerance induction dependent upon immune response" NARROW []
synonym: "negative regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "activation of tolerance induction dependent upon immune response" NARROW []
synonym: "positive regulation of immune response-dependent tolerance induction" EXACT []
synonym: "stimulation of tolerance induction dependent upon immune response" NARROW []
synonym: "up regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "upregulation of tolerance induction dependent upon immune response" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response
relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002655
name: regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002656
name: negative regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "down regulation of tolerance induction to nonself antigen" EXACT []
synonym: "down-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "downregulation of tolerance induction to nonself antigen" EXACT []
synonym: "inhibition of tolerance induction to nonself antigen" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002657
name: positive regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "activation of tolerance induction to nonself antigen" NARROW []
synonym: "stimulation of tolerance induction to nonself antigen" NARROW []
synonym: "up regulation of tolerance induction to nonself antigen" EXACT []
synonym: "up-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "upregulation of tolerance induction to nonself antigen" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002462 ! tolerance induction to nonself antigen
relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002658
name: regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002465 ! peripheral tolerance induction
relationship: regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002659
name: negative regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "down regulation of peripheral tolerance induction" EXACT []
synonym: "down-regulation of peripheral tolerance induction" EXACT []
synonym: "downregulation of peripheral tolerance induction" EXACT []
synonym: "inhibition of peripheral tolerance induction" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002465 ! peripheral tolerance induction
relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002660
name: positive regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "activation of peripheral tolerance induction" NARROW []
synonym: "stimulation of peripheral tolerance induction" NARROW []
synonym: "up regulation of peripheral tolerance induction" EXACT []
synonym: "up-regulation of peripheral tolerance induction" EXACT []
synonym: "upregulation of peripheral tolerance induction" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002465 ! peripheral tolerance induction
relationship: positively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002661
name: regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "regulation of B lymphocyte tolerance induction" EXACT []
synonym: "regulation of B-cell tolerance induction" EXACT []
synonym: "regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002514 ! B cell tolerance induction
relationship: regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002662
name: negative regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "down regulation of B cell tolerance induction" EXACT []
synonym: "down-regulation of B cell tolerance induction" EXACT []
synonym: "downregulation of B cell tolerance induction" EXACT []
synonym: "inhibition of B cell tolerance induction" NARROW []
synonym: "negative regulation of B lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of B-cell tolerance induction" EXACT []
synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002514 ! B cell tolerance induction
relationship: negatively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002663
name: positive regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "activation of B cell tolerance induction" NARROW []
synonym: "positive regulation of B lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of B-cell tolerance induction" EXACT []
synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of B cell tolerance induction" NARROW []
synonym: "up regulation of B cell tolerance induction" EXACT []
synonym: "up-regulation of B cell tolerance induction" EXACT []
synonym: "upregulation of B cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002514 ! B cell tolerance induction
relationship: positively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002664
name: regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "regulation of T lymphocyte tolerance induction" EXACT []
synonym: "regulation of T-cell tolerance induction" EXACT []
synonym: "regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002517 ! T cell tolerance induction
relationship: regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002665
name: negative regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "down regulation of T cell tolerance induction" EXACT []
synonym: "down-regulation of T cell tolerance induction" EXACT []
synonym: "downregulation of T cell tolerance induction" EXACT []
synonym: "inhibition of T cell tolerance induction" NARROW []
synonym: "negative regulation of T lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of T-cell tolerance induction" EXACT []
synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002517 ! T cell tolerance induction
relationship: negatively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002666
name: positive regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "activation of T cell tolerance induction" NARROW []
synonym: "positive regulation of T lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of T-cell tolerance induction" EXACT []
synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of T cell tolerance induction" NARROW []
synonym: "up regulation of T cell tolerance induction" EXACT []
synonym: "up-regulation of T cell tolerance induction" EXACT []
synonym: "upregulation of T cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002517 ! T cell tolerance induction
relationship: positively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002667
name: regulation of T cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "regulation of T lymphocyte anergy" EXACT []
synonym: "regulation of T-cell anergy" EXACT []
synonym: "regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002870 ! T cell anergy
relationship: regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002668
name: negative regulation of T cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "down regulation of T cell anergy" EXACT []
synonym: "down-regulation of T cell anergy" EXACT []
synonym: "downregulation of T cell anergy" EXACT []
synonym: "inhibition of T cell anergy" NARROW []
synonym: "negative regulation of T lymphocyte anergy" EXACT []
synonym: "negative regulation of T-cell anergy" EXACT []
synonym: "negative regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002870 ! T cell anergy
relationship: negatively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002669
name: positive regulation of T cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "activation of T cell anergy" NARROW []
synonym: "positive regulation of T lymphocyte anergy" EXACT []
synonym: "positive regulation of T-cell anergy" EXACT []
synonym: "positive regulation of T-lymphocyte anergy" EXACT []
synonym: "stimulation of T cell anergy" NARROW []
synonym: "up regulation of T cell anergy" EXACT []
synonym: "up-regulation of T cell anergy" EXACT []
synonym: "upregulation of T cell anergy" EXACT []
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002870 ! T cell anergy
relationship: positively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002670
name: regulation of B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "regulation of B lymphocyte anergy" EXACT []
synonym: "regulation of B-cell anergy" EXACT []
synonym: "regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002515 ! B cell anergy
relationship: regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002671
name: negative regulation of B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "down regulation of B cell anergy" EXACT []
synonym: "down-regulation of B cell anergy" EXACT []
synonym: "downregulation of B cell anergy" EXACT []
synonym: "inhibition of B cell anergy" NARROW []
synonym: "negative regulation of B lymphocyte anergy" EXACT []
synonym: "negative regulation of B-cell anergy" EXACT []
synonym: "negative regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002515 ! B cell anergy
relationship: negatively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002672
name: positive regulation of B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "activation of B cell anergy" NARROW []
synonym: "positive regulation of B lymphocyte anergy" EXACT []
synonym: "positive regulation of B-cell anergy" EXACT []
synonym: "positive regulation of B-lymphocyte anergy" EXACT []
synonym: "stimulation of B cell anergy" NARROW []
synonym: "up regulation of B cell anergy" EXACT []
synonym: "up-regulation of B cell anergy" EXACT []
synonym: "upregulation of B cell anergy" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002515 ! B cell anergy
relationship: positively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002673
name: regulation of acute inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002526 ! acute inflammatory response
relationship: regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002674
name: negative regulation of acute inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "down regulation of acute inflammatory response" EXACT []
synonym: "down-regulation of acute inflammatory response" EXACT []
synonym: "downregulation of acute inflammatory response" EXACT []
synonym: "inhibition of acute inflammatory response" NARROW []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002526 ! acute inflammatory response
relationship: negatively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002675
name: positive regulation of acute inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "activation of acute inflammatory response" NARROW []
synonym: "stimulation of acute inflammatory response" NARROW []
synonym: "up regulation of acute inflammatory response" EXACT []
synonym: "up-regulation of acute inflammatory response" EXACT []
synonym: "upregulation of acute inflammatory response" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002526 ! acute inflammatory response
relationship: positively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002676
name: regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002544 ! chronic inflammatory response
relationship: regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002677
name: negative regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "down regulation of chronic inflammatory response" EXACT []
synonym: "down-regulation of chronic inflammatory response" EXACT []
synonym: "downregulation of chronic inflammatory response" EXACT []
synonym: "inhibition of chronic inflammatory response" NARROW []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002544 ! chronic inflammatory response
relationship: negatively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002678
name: positive regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "activation of chronic inflammatory response" NARROW []
synonym: "stimulation of chronic inflammatory response" NARROW []
synonym: "up regulation of chronic inflammatory response" EXACT []
synonym: "up-regulation of chronic inflammatory response" EXACT []
synonym: "upregulation of chronic inflammatory response" EXACT []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002544 ! chronic inflammatory response
relationship: positively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002679
name: respiratory burst involved in defense response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499]
is_a: GO:0002252 ! immune effector process
is_a: GO:0045730 ! respiratory burst
intersection_of: GO:0045730 ! respiratory burst
intersection_of: part_of GO:0006952 ! defense response
relationship: part_of GO:0006952 ! defense response

[Term]
id: GO:0002680
name: pro-T cell lineage commitment
namespace: biological_process
def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149]
synonym: "pro-T cell fate commitment" EXACT []
synonym: "pro-T lymphocyte fate commitment" EXACT []
synonym: "pro-T lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:0002681
name: somatic recombination of T cell receptor gene segments
namespace: biological_process
def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149]
synonym: "somatic recombination of TCR gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0002568 ! somatic diversification of T cell receptor genes

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002376 ! immune system process
relationship: regulates GO:0002376 ! immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002376 ! immune system process
relationship: negatively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002376 ! immune system process
relationship: positively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0050900 ! leukocyte migration
relationship: regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0050900 ! leukocyte migration
relationship: negatively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0050900 ! leukocyte migration
relationship: positively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0030595 ! leukocyte chemotaxis
relationship: regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0030595 ! leukocyte chemotaxis
relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0030595 ! leukocyte chemotaxis
relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002691
name: regulation of cellular extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add]
is_a: GO:0002685 ! regulation of leukocyte migration
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045123 ! cellular extravasation
relationship: regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002692
name: negative regulation of cellular extravasation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "down regulation of cellular extravasation" EXACT []
synonym: "down-regulation of cellular extravasation" EXACT []
synonym: "downregulation of cellular extravasation" EXACT []
synonym: "inhibition of cellular extravasation" NARROW []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045123 ! cellular extravasation
relationship: negatively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002693
name: positive regulation of cellular extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "activation of cellular extravasation" NARROW []
synonym: "stimulation of cellular extravasation" NARROW []
synonym: "up regulation of cellular extravasation" EXACT []
synonym: "up-regulation of cellular extravasation" EXACT []
synonym: "upregulation of cellular extravasation" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045123 ! cellular extravasation
relationship: positively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0045321 ! leukocyte activation
relationship: regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0045321 ! leukocyte activation
relationship: negatively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0045321 ! leukocyte activation
relationship: positively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002252 ! immune effector process
relationship: regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002252 ! immune effector process
relationship: negatively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002252 ! immune effector process
relationship: positively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002440 ! production of molecular mediator of immune response
relationship: regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002440 ! production of molecular mediator of immune response
relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002443 ! leukocyte mediated immunity
relationship: regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity
relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity
relationship: regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity
relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002456 ! T cell mediated immunity
relationship: regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002456 ! T cell mediated immunity
relationship: negatively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002456 ! T cell mediated immunity
relationship: positively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "regulation of B lymphocyte mediated immunity" EXACT []
synonym: "regulation of B-cell mediated immunity" EXACT []
synonym: "regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019724 ! B cell mediated immunity
relationship: regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002713
name: negative regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "down regulation of B cell mediated immunity" EXACT []
synonym: "down-regulation of B cell mediated immunity" EXACT []
synonym: "downregulation of B cell mediated immunity" EXACT []
synonym: "inhibition of B cell mediated immunity" NARROW []
synonym: "negative regulation of B lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of B-cell mediated immunity" EXACT []
synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0019724 ! B cell mediated immunity
relationship: negatively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "activation of B cell mediated immunity" NARROW []
synonym: "positive regulation of B lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of B-cell mediated immunity" EXACT []
synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of B cell mediated immunity" NARROW []
synonym: "up regulation of B cell mediated immunity" EXACT []
synonym: "up-regulation of B cell mediated immunity" EXACT []
synonym: "upregulation of B cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019724 ! B cell mediated immunity
relationship: positively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002715
name: regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045845
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "regulation of natural killer cell activity" RELATED []
synonym: "regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0045088 ! regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002228 ! natural killer cell mediated immunity
relationship: regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0030102
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "down regulation of natural killer cell mediated immunity" EXACT []
synonym: "down-regulation of natural killer cell mediated immunity" EXACT []
synonym: "downregulation of natural killer cell mediated immunity" EXACT []
synonym: "inhibition of natural killer cell mediated immunity" NARROW []
synonym: "negative regulation of natural killer cell activity" RELATED []
synonym: "negative regulation of NK cell activity" RELATED []
synonym: "negative regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045824 ! negative regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002228 ! natural killer cell mediated immunity
relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045846
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "activation of natural killer cell mediated immunity" NARROW []
synonym: "positive regulation of natural killer cell activity" RELATED []
synonym: "positive regulation of NK cell activity" RELATED []
synonym: "positive regulation of NK cell mediated immunity" EXACT []
synonym: "stimulation of natural killer cell mediated immunity" NARROW []
synonym: "up regulation of natural killer cell mediated immunity" EXACT []
synonym: "up-regulation of natural killer cell mediated immunity" EXACT []
synonym: "upregulation of natural killer cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045089 ! positive regulation of innate immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002228 ! natural killer cell mediated immunity
relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002367 ! cytokine production involved in immune response
relationship: regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" RELATED []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" RELATED []
synonym: "inhibition of cytokine production during immune response" RELATED []
synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" RELATED []
synonym: "up-regulation of cytokine production during immune response" RELATED []
synonym: "upregulation of cytokine production during immune response" RELATED []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002367 ! cytokine production involved in immune response
relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response

[Term]
id: GO:0002721
name: regulation of B cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "regulation of B lymphocyte cytokine production" EXACT []
synonym: "regulation of B-cell cytokine production" EXACT []
synonym: "regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002368 ! B cell cytokine production
relationship: regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002722
name: negative regulation of B cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "down regulation of B cell cytokine production" EXACT []
synonym: "down-regulation of B cell cytokine production" EXACT []
synonym: "downregulation of B cell cytokine production" EXACT []
synonym: "inhibition of B cell cytokine production" NARROW []
synonym: "negative regulation of B lymphocyte cytokine production" EXACT []
synonym: "negative regulation of B-cell cytokine production" EXACT []
synonym: "negative regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002368 ! B cell cytokine production
relationship: negatively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002723
name: positive regulation of B cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "activation of B cell cytokine production" NARROW []
synonym: "positive regulation of B lymphocyte cytokine production" EXACT []
synonym: "positive regulation of B-cell cytokine production" EXACT []
synonym: "positive regulation of B-lymphocyte cytokine production" EXACT []
synonym: "stimulation of B cell cytokine production" NARROW []
synonym: "up regulation of B cell cytokine production" EXACT []
synonym: "up-regulation of B cell cytokine production" EXACT []
synonym: "upregulation of B cell cytokine production" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002368 ! B cell cytokine production
relationship: positively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002369 ! T cell cytokine production
relationship: regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002369 ! T cell cytokine production
relationship: negatively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002369 ! T cell cytokine production
relationship: positively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002727
name: regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "regulation of NK cell cytokine production" EXACT []
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002370 ! natural killer cell cytokine production
relationship: regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002728
name: negative regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "down regulation of natural killer cell cytokine production" EXACT []
synonym: "down-regulation of natural killer cell cytokine production" EXACT []
synonym: "downregulation of natural killer cell cytokine production" EXACT []
synonym: "inhibition of natural killer cell cytokine production" NARROW []
synonym: "negative regulation of NK cell cytokine production" EXACT []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002370 ! natural killer cell cytokine production
relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002729
name: positive regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "activation of natural killer cell cytokine production" NARROW []
synonym: "positive regulation of NK cell cytokine production" EXACT []
synonym: "stimulation of natural killer cell cytokine production" NARROW []
synonym: "up regulation of natural killer cell cytokine production" EXACT []
synonym: "up-regulation of natural killer cell cytokine production" EXACT []
synonym: "upregulation of natural killer cell cytokine production" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002370 ! natural killer cell cytokine production
relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002371 ! dendritic cell cytokine production
relationship: regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002371 ! dendritic cell cytokine production
relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production
relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002736
name: regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002737
name: negative regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002738
name: positive regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production
relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002739
name: regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0050707 ! regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002740
name: negative regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine secretion during immune response" RELATED []
synonym: "down-regulation of cytokine secretion during immune response" RELATED []
synonym: "downregulation of cytokine secretion during immune response" RELATED []
synonym: "inhibition of cytokine secretion during immune response" NARROW []
synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph]
is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
is_a: GO:0050710 ! negative regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002741
name: positive regulation of cytokine secretion involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]
synonym: "activation of cytokine secretion during immune response" NARROW []
synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine secretion during immune response" NARROW []
synonym: "up regulation of cytokine secretion during immune response" RELATED []
synonym: "up-regulation of cytokine secretion during immune response" RELATED []
synonym: "upregulation of cytokine secretion during immune response" RELATED []
is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response
is_a: GO:0050715 ! positive regulation of cytokine secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response
relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response

[Term]
id: GO:0002742
name: regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add]
synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002718 ! regulation of cytokine production involved in immune response
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002743
name: negative regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW []
synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002744
name: positive regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]
synonym: "activation of cytokine biosynthetic process during immune response" NARROW []
synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph]
synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW []
synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED []
synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED []
is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response
relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response

[Term]
id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002746
name: antigen processing and presentation following pinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002747
name: antigen processing and presentation following phagocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002748
name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149]
synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT []
synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT []
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002749
name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122]
synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT []
is_a: GO:0002747 ! antigen processing and presentation following phagocytosis
is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

[Term]
id: GO:0002750
name: antigen processing and presentation following macropinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257]
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002751
name: antigen processing and presentation following receptor mediated endocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149]
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002752
name: cell surface pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "cell surface PAMP receptor signaling pathway" EXACT []
synonym: "cell surface pathogen receptor signaling pathway" EXACT []
synonym: "cell surface pattern recognition receptor signalling pathway" EXACT []
synonym: "cell surface PRR signaling pathway" EXACT []
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002753
name: cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located in the cytoplasm. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT []
synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT []
synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT []
synonym: "cytoplasmic PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
is_a: GO:0030522 ! intracellular receptor mediated signaling pathway
intersection_of: GO:0002221 ! pattern recognition receptor signaling pathway
intersection_of: occurs_in GO:0005737 ! cytoplasm

[Term]
id: GO:0002754
name: intracellular vesicle pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149, PMID:15199967]
synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT []
synonym: "intracellular vesicle PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway
is_a: GO:0030522 ! intracellular receptor mediated signaling pathway

[Term]
id: GO:0002755
name: MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-dependent TLR signaling pathway" EXACT []
synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_100168 "MyD88 cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_101942 "MyD88:Mal cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_104035 "MyD88 cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_106952 "MyD88 cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_107977 "MyD88:Mal cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_110031 "MyD88 cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_25089 "MyD88:TIRAP-dependent cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_27215 "MyD88 cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_27254 "MyD88-dependent cascade initiated on endosome membrane, Gallus gallus"
xref: Reactome:REACT_27259 "MyD88 cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_28050 "MyD88:Mal cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_30270 "MyD88 cascade initiated on plasma membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_32510 "MyD88:Mal cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_34594 "MyD88:Mal cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_6788 "MyD88:Mal cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_79855 "MyD88:Mal cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_80624 "MyD88:Mal cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_80969 "MyD88:Mal cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_81173 "MyD88 cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_81183 "MyD88 cascade initiated on plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_85347 "MyD88:Mal cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_85793 "MyD88:Mal cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_88707 "MyD88 cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_88909 "MyD88 cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_90702 "MyD88:Mal cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_92018 "MyD88:Mal cascade initiated on plasma membrane, Drosophila melanogaster"
xref: Reactome:REACT_92143 "MyD88:Mal cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_93524 "MyD88 cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_93873 "MyD88 cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_95154 "MyD88 cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_95427 "MyD88 cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_95678 "MyD88 cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_96158 "MyD88:Mal cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_96187 "MyD88 cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_96209 "MyD88 cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_99530 "MyD88:Mal cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_99838 "MyD88:Mal cascade initiated on plasma membrane, Schizosaccharomyces pombe"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002756
name: MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-independent TLR signaling pathway" EXACT []
synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT []
xref: Reactome:REACT_100200 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Gallus gallus"
xref: Reactome:REACT_102299 "MyD88-independent cascade initiated on plasma membrane, Caenorhabditis elegans"
xref: Reactome:REACT_102509 "TRAF6 Mediated Induction of proinflammatory cytokines, Dictyostelium discoideum"
xref: Reactome:REACT_102886 "TRAF6 Mediated Induction of proinflammatory cytokines, Saccharomyces cerevisiae"
xref: Reactome:REACT_104655 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Mus musculus"
xref: Reactome:REACT_105840 "TRAF6 Mediated Induction of proinflammatory cytokines, Gallus gallus"
xref: Reactome:REACT_105924 "TRAF6 Mediated Induction of proinflammatory cytokines, Mus musculus"
xref: Reactome:REACT_106037 "TRAF6 Mediated Induction of proinflammatory cytokines, Canis familiaris"
xref: Reactome:REACT_106039 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Mus musculus"
xref: Reactome:REACT_106964 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Danio rerio"
xref: Reactome:REACT_109458 "TRAF6 Mediated Induction of proinflammatory cytokines, Rattus norvegicus"
xref: Reactome:REACT_110829 "MyD88-independent cascade initiated on plasma membrane, Canis familiaris"
xref: Reactome:REACT_110980 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Danio rerio"
xref: Reactome:REACT_114143 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Drosophila melanogaster"
xref: Reactome:REACT_25148 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Homo sapiens"
xref: Reactome:REACT_28259 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Xenopus tropicalis"
xref: Reactome:REACT_28395 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Bos taurus"
xref: Reactome:REACT_28410 "MyD88-independent cascade initiated on plasma membrane, Oryza sativa"
xref: Reactome:REACT_28525 "MyD88-independent cascade initiated on plasma membrane, Schizosaccharomyces pombe"
xref: Reactome:REACT_29826 "MyD88-independent cascade initiated on plasma membrane, Gallus gallus"
xref: Reactome:REACT_30390 "TRAF6 Mediated Induction of proinflammatory cytokines, Arabidopsis thaliana"
xref: Reactome:REACT_31920 "TRAF6 Mediated Induction of proinflammatory cytokines, Sus scrofa"
xref: Reactome:REACT_32587 "MyD88-independent cascade initiated on plasma membrane, Mus musculus"
xref: Reactome:REACT_32888 "MyD88-independent cascade initiated on plasma membrane, Sus scrofa"
xref: Reactome:REACT_33115 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Taeniopygia guttata"
xref: Reactome:REACT_33276 "MyD88-independent cascade initiated on plasma membrane, Danio rerio"
xref: Reactome:REACT_33454 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Sus scrofa"
xref: Reactome:REACT_33857 "TRAF6 Mediated Induction of proinflammatory cytokines, Oryza sativa"
xref: Reactome:REACT_34578 "TRAF6 Mediated Induction of proinflammatory cytokines, Drosophila melanogaster"
xref: Reactome:REACT_6782 "TRAF6 Mediated Induction of proinflammatory cytokines, Homo sapiens"
xref: Reactome:REACT_6809 "MyD88-independent cascade initiated on plasma membrane, Homo sapiens"
xref: Reactome:REACT_6898 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Homo sapiens"
xref: Reactome:REACT_6976 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Homo sapiens"
xref: Reactome:REACT_70758 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Gallus gallus"
xref: Reactome:REACT_78892 "MyD88-independent cascade initiated on plasma membrane, Saccharomyces cerevisiae"
xref: Reactome:REACT_79777 "TRAF6 Mediated Induction of proinflammatory cytokines, Caenorhabditis elegans"
xref: Reactome:REACT_81045 "TRAF6 Mediated Induction of proinflammatory cytokines, Danio rerio"
xref: Reactome:REACT_81308 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Bos taurus"
xref: Reactome:REACT_81312 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Sus scrofa"
xref: Reactome:REACT_82068 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Rattus norvegicus"
xref: Reactome:REACT_83083 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Canis familiaris"
xref: Reactome:REACT_85389 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Rattus norvegicus"
xref: Reactome:REACT_85560 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Rattus norvegicus"
xref: Reactome:REACT_85813 "MyD88-independent cascade initiated on plasma membrane, Arabidopsis thaliana"
xref: Reactome:REACT_87120 "MyD88-independent cascade initiated on plasma membrane, Dictyostelium discoideum"
xref: Reactome:REACT_88311 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Xenopus tropicalis"
xref: Reactome:REACT_88396 "MyD88-independent cascade initiated on plasma membrane, Xenopus tropicalis"
xref: Reactome:REACT_88627 "TRAF6 Mediated Induction of proinflammatory cytokines, Schizosaccharomyces pombe"
xref: Reactome:REACT_89370 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Xenopus tropicalis"
xref: Reactome:REACT_89942 "MyD88-independent cascade initiated on plasma membrane, Rattus norvegicus"
xref: Reactome:REACT_90312 "TRAF6 Mediated Induction of proinflammatory cytokines, Bos taurus"
xref: Reactome:REACT_91487 "TRAF6 Mediated Induction of proinflammatory cytokines, Xenopus tropicalis"
xref: Reactome:REACT_91606 "MyD88-independent cascade initiated on plasma membrane, Taeniopygia guttata"
xref: Reactome:REACT_92796 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Taeniopygia guttata"
xref: Reactome:REACT_93657 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Canis familiaris"
xref: Reactome:REACT_94894 "TRAF6 Mediated Induction of proinflammatory cytokines, Taeniopygia guttata"
xref: Reactome:REACT_95971 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Taeniopygia guttata"
xref: Reactome:REACT_96392 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Bos taurus"
xref: Reactome:REACT_96482 "MyD88-independent cascade initiated on plasma membrane, Bos taurus"
xref: Reactome:REACT_97209 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Gallus gallus"
xref: Reactome:REACT_98583 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Sus scrofa"
xref: Reactome:REACT_99022 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Danio rerio"
xref: Reactome:REACT_99202 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Canis familiaris"
xref: Reactome:REACT_99347 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Mus musculus"
xref: Reactome:REACT_99643 "MyD88-independent cascade initiated on plasma membrane, Drosophila melanogaster"
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002757
name: immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add]
is_a: GO:0002253 ! activation of immune response
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002758
name: innate immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002757 ! immune response-activating signal transduction

[Term]
id: GO:0002759
name: regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0043900 ! regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0019730 ! antimicrobial humoral response
relationship: regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002760
name: positive regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
synonym: "activation of antimicrobial humoral response" NARROW []
synonym: "stimulation of antimicrobial humoral response" NARROW []
synonym: "up regulation of antimicrobial humoral response" EXACT []
synonym: "up-regulation of antimicrobial humoral response" EXACT []
synonym: "upregulation of antimicrobial humoral response" EXACT []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0043902 ! positive regulation of multi-organism process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0019730 ! antimicrobial humoral response
relationship: positively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation
relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002764
name: immune response-regulating signaling pathway
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002765
name: immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149]
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002766
name: innate immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
is_a: GO:0002765 ! immune response-inhibiting signal transduction

[Term]
id: GO:0002767
name: immune response-inhibiting cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT []
is_a: GO:0002765 ! immune response-inhibiting signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002768
name: immune response-regulating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002764 ! immune response-regulating signaling pathway
is_a: GO:0007166 ! cell surface receptor signaling pathway

[Term]
id: GO:0002769
name: natural killer cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory KIR signaling pathway" NARROW []
synonym: "killer cell inhibitory receptor signaling pathway" NARROW []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
synonym: "natural killer cell inhibitory signalling pathway" EXACT []
synonym: "NK cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002770
name: T cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309]
synonym: "T cell inhibitory signalling pathway" EXACT []
synonym: "T lymphocyte inhibitory signaling pathway" EXACT []
synonym: "T-cell inhibitory signaling pathway" EXACT []
synonym: "T-lymphocyte inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002771
name: inhibitory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "killer cell inhibitory receptor signaling pathway" EXACT []
synonym: "KIR signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002772
name: inhibitory C-type lectin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]
synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT []
synonym: "Ly49 inhibitory receptor signaling pathway" RELATED []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002773
name: B cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920]
synonym: "B cell inhibitory signalling pathway" EXACT []
synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT []
synonym: "B-cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002774
name: Fc receptor mediated inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149]
synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT []
synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002776
name: antimicrobial peptide secretion
namespace: biological_process
def: "The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002790 ! peptide secretion
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002777
name: antimicrobial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0043043 ! peptide biosynthetic process
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0002779
name: antibacterial peptide secretion
namespace: biological_process
def: "The regulated release of an antibacterial peptide from a cell or group of cells." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002780
name: antibacterial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019732 ! antifungal humoral response

[Term]
id: GO:0002782
name: antifungal peptide secretion
namespace: biological_process
def: "The regulated release of an antifungal peptide from a cell or group of cells." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002783
name: antifungal peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002784
name: regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0002759 ! regulation of antimicrobial humoral response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002775 ! antimicrobial peptide production
relationship: regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002785
name: negative regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
synonym: "down regulation of antimicrobial peptide production" EXACT []
synonym: "down-regulation of antimicrobial peptide production" EXACT []
synonym: "downregulation of antimicrobial peptide production" EXACT []
synonym: "inhibition of antimicrobial peptide production" NARROW []
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002775 ! antimicrobial peptide production
relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002786
name: regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:1900424 ! regulation of defense response to bacterium
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002778 ! antibacterial peptide production
relationship: regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002787
name: negative regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "down regulation of antibacterial peptide production" EXACT []
synonym: "down-regulation of antibacterial peptide production" EXACT []
synonym: "downregulation of antibacterial peptide production" EXACT []
synonym: "inhibition of antibacterial peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002778 ! antibacterial peptide production
relationship: negatively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002788
name: regulation of antifungal peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:1900150 ! regulation of defense response to fungus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002781 ! antifungal peptide production
relationship: regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002789
name: negative regulation of antifungal peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "down regulation of antifungal peptide production" EXACT []
synonym: "down-regulation of antifungal peptide production" EXACT []
synonym: "downregulation of antifungal peptide production" EXACT []
synonym: "inhibition of antifungal peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002781 ! antifungal peptide production
relationship: negatively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or group of cells." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002790 ! peptide secretion
relationship: regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002790 ! peptide secretion
relationship: negatively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002790 ! peptide secretion
relationship: positively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002794
name: regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0002791 ! regulation of peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002776 ! antimicrobial peptide secretion
relationship: regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "down regulation of antimicrobial peptide secretion" EXACT []
synonym: "down-regulation of antimicrobial peptide secretion" EXACT []
synonym: "downregulation of antimicrobial peptide secretion" EXACT []
synonym: "inhibition of antimicrobial peptide secretion" NARROW []
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002776 ! antimicrobial peptide secretion
relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "activation of antimicrobial peptide secretion" NARROW []
synonym: "stimulation of antimicrobial peptide secretion" NARROW []
synonym: "up regulation of antimicrobial peptide secretion" EXACT []
synonym: "up-regulation of antimicrobial peptide secretion" EXACT []
synonym: "upregulation of antimicrobial peptide secretion" EXACT []
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002776 ! antimicrobial peptide secretion
relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002797
name: regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002779 ! antibacterial peptide secretion
relationship: regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002798
name: negative regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "down regulation of antibacterial peptide secretion" EXACT []
synonym: "down-regulation of antibacterial peptide secretion" EXACT []
synonym: "downregulation of antibacterial peptide secretion" EXACT []
synonym: "inhibition of antibacterial peptide secretion" NARROW []
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002779 ! antibacterial peptide secretion
relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002799
name: positive regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "activation of antibacterial peptide secretion" NARROW []
synonym: "stimulation of antibacterial peptide secretion" NARROW []
synonym: "up regulation of antibacterial peptide secretion" EXACT []
synonym: "up-regulation of antibacterial peptide secretion" EXACT []
synonym: "upregulation of antibacterial peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002779 ! antibacterial peptide secretion
relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002800
name: regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002782 ! antifungal peptide secretion
relationship: regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002801
name: negative regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "down regulation of antifungal peptide secretion" EXACT []
synonym: "down-regulation of antifungal peptide secretion" EXACT []
synonym: "downregulation of antifungal peptide secretion" EXACT []
synonym: "inhibition of antifungal peptide secretion" NARROW []
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002782 ! antifungal peptide secretion
relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002802
name: positive regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "activation of antifungal peptide secretion" NARROW []
synonym: "stimulation of antifungal peptide secretion" NARROW []
synonym: "up regulation of antifungal peptide secretion" EXACT []
synonym: "up-regulation of antifungal peptide secretion" EXACT []
synonym: "upregulation of antifungal peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002782 ! antifungal peptide secretion
relationship: positively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002803
name: positive regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "activation of antibacterial peptide production" NARROW []
synonym: "stimulation of antibacterial peptide production" NARROW []
synonym: "up regulation of antibacterial peptide production" EXACT []
synonym: "up-regulation of antibacterial peptide production" EXACT []
synonym: "upregulation of antibacterial peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002778 ! antibacterial peptide production
relationship: positively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002804
name: positive regulation of antifungal peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "activation of antifungal peptide production" NARROW []
synonym: "stimulation of antifungal peptide production" NARROW []
synonym: "up regulation of antifungal peptide production" EXACT []
synonym: "up-regulation of antifungal peptide production" EXACT []
synonym: "upregulation of antifungal peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002781 ! antifungal peptide production
relationship: positively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002805
name: regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0031326 ! regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002806
name: negative regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW []
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002807
name: positive regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "activation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT []
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002808
name: regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002780 ! antibacterial peptide biosynthetic process
relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002809
name: negative regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW []
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process
relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002810
name: regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002783 ! antifungal peptide biosynthetic process
relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002811
name: negative regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
synonym: "down regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "downregulation of antifungal peptide biosynthetic process" EXACT []
synonym: "inhibition of antifungal peptide biosynthetic process" NARROW []
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process
relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002812
name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0002813
name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002814
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002815
name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0002816
name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002817
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002818
name: intracellular defense response
namespace: biological_process
def: "A physiological defense response which occurs intracellularly." [GOC:add]
synonym: "intracellular defence response" EXACT []
is_a: GO:0006968 ! cellular defense response
is_a: GO:0033554 ! cellular response to stress
intersection_of: GO:0006952 ! defense response
intersection_of: occurs_in GO:0005622 ! intracellular

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002250 ! adaptive immune response
relationship: regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002250 ! adaptive immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002250 ! adaptive immune response
relationship: positively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002825
name: regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042088 ! T-helper 1 type immune response
relationship: regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002826
name: negative regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "down regulation of T-helper 1 type immune response" EXACT []
synonym: "down-regulation of T-helper 1 type immune response" EXACT []
synonym: "downregulation of T-helper 1 type immune response" EXACT []
synonym: "inhibition of T-helper 1 type immune response" NARROW []
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042088 ! T-helper 1 type immune response
relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002827
name: positive regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "activation of T-helper 1 type immune response" NARROW []
synonym: "stimulation of T-helper 1 type immune response" NARROW []
synonym: "up regulation of T-helper 1 type immune response" EXACT []
synonym: "up-regulation of T-helper 1 type immune response" EXACT []
synonym: "upregulation of T-helper 1 type immune response" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042088 ! T-helper 1 type immune response
relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002828
name: regulation of type 2 immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0042092 ! type 2 immune response
relationship: regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002829
name: negative regulation of type 2 immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "down regulation of type 2 immune response" EXACT []
synonym: "down-regulation of type 2 immune response" EXACT []
synonym: "downregulation of type 2 immune response" EXACT []
synonym: "inhibition of type 2 immune response" NARROW []
synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "negative regulation of Th2 immune response" NARROW [GOC:add]
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0042092 ! type 2 immune response
relationship: negatively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002830
name: positive regulation of type 2 immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add]
synonym: "activation of type 2 immune response" NARROW []
synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add]
synonym: "positive regulation of Th2 immune response" NARROW [GOC:add]
synonym: "stimulation of type 2 immune response" NARROW []
synonym: "up regulation of type 2 immune response" EXACT []
synonym: "up-regulation of type 2 immune response" EXACT []
synonym: "upregulation of type 2 immune response" EXACT []
is_a: GO:0002828 ! regulation of type 2 immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0042092 ! type 2 immune response
relationship: positively_regulates GO:0042092 ! type 2 immune response

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
is_a: GO:0048583 ! regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0009607 ! response to biotic stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002834
name: regulation of response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "regulation of response to tumour cell" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002347 ! response to tumor cell
relationship: regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002835
name: negative regulation of response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "down regulation of response to tumor cell" EXACT []
synonym: "down-regulation of response to tumor cell" EXACT []
synonym: "downregulation of response to tumor cell" EXACT []
synonym: "inhibition of response to tumor cell" NARROW []
synonym: "negative regulation of response to tumour cell" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002347 ! response to tumor cell
relationship: negatively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002836
name: positive regulation of response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "activation of response to tumor cell" NARROW []
synonym: "positive regulation of response to tumour cell" EXACT []
synonym: "stimulation of response to tumor cell" NARROW []
synonym: "up regulation of response to tumor cell" EXACT []
synonym: "up-regulation of response to tumor cell" EXACT []
synonym: "upregulation of response to tumor cell" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002347 ! response to tumor cell
relationship: positively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002837
name: regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "regulation of immune response to tumour cell" EXACT []
is_a: GO:0002834 ! regulation of response to tumor cell
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002418 ! immune response to tumor cell
relationship: regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002838
name: negative regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "down regulation of immune response to tumor cell" EXACT []
synonym: "down-regulation of immune response to tumor cell" EXACT []
synonym: "downregulation of immune response to tumor cell" EXACT []
synonym: "inhibition of immune response to tumor cell" NARROW []
synonym: "negative regulation of immune response to tumour cell" EXACT []
is_a: GO:0002835 ! negative regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002418 ! immune response to tumor cell
relationship: negatively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002839
name: positive regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "activation of immune response to tumor cell" NARROW []
synonym: "positive regulation of immune response to tumour cell" EXACT []
synonym: "stimulation of immune response to tumor cell" NARROW []
synonym: "up regulation of immune response to tumor cell" EXACT []
synonym: "up-regulation of immune response to tumor cell" EXACT []
synonym: "upregulation of immune response to tumor cell" EXACT []
is_a: GO:0002836 ! positive regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002418 ! immune response to tumor cell
relationship: positively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002840
name: regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002841
name: negative regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW []
synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002842
name: positive regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "activation of T cell mediated immune response to tumor cell" NARROW []
synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002843
name: regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002413 ! tolerance induction to tumor cell
relationship: regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002844
name: negative regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of tolerance induction to tumor cell" EXACT []
synonym: "downregulation of tolerance induction to tumor cell" EXACT []
synonym: "inhibition of tolerance induction to tumor cell" NARROW []
synonym: "negative regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002413 ! tolerance induction to tumor cell
relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002845
name: positive regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "activation of tolerance induction to tumor cell" NARROW []
synonym: "positive regulation of tolerance induction to tumour cell" EXACT []
synonym: "stimulation of tolerance induction to tumor cell" NARROW []
synonym: "up regulation of tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of tolerance induction to tumor cell" EXACT []
synonym: "upregulation of tolerance induction to tumor cell" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002413 ! tolerance induction to tumor cell
relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002846
name: regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002847
name: negative regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW []
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002848
name: positive regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "activation of T cell tolerance induction to tumor cell" NARROW []
synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW []
synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT []
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell
relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002849
name: regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002709 ! regulation of T cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002850
name: negative regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "down regulation of peripheral T cell tolerance induction" EXACT []
synonym: "down-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "downregulation of peripheral T cell tolerance induction" EXACT []
synonym: "inhibition of peripheral T cell tolerance induction" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002851
name: positive regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "activation of peripheral T cell tolerance induction" NARROW []
synonym: "stimulation of peripheral T cell tolerance induction" NARROW []
synonym: "up regulation of peripheral T cell tolerance induction" EXACT []
synonym: "up-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "upregulation of peripheral T cell tolerance induction" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002458 ! peripheral T cell tolerance induction
relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002852
name: regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002853
name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002854
name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002855
name: regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002856
name: negative regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002857
name: positive regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002858
name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002859
name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002860
name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002861
name: regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002862
name: negative regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002863
name: positive regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002864
name: regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002865
name: negative regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002866
name: positive regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002867
name: regulation of B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "regulation of B lymphocyte deletion" EXACT []
synonym: "regulation of B-cell deletion" EXACT []
synonym: "regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002902 ! regulation of B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002516 ! B cell deletion
relationship: regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002868
name: negative regulation of B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "down regulation of B cell deletion" EXACT []
synonym: "down-regulation of B cell deletion" EXACT []
synonym: "downregulation of B cell deletion" EXACT []
synonym: "inhibition of B cell deletion" NARROW []
synonym: "negative regulation of B lymphocyte deletion" EXACT []
synonym: "negative regulation of B-cell deletion" EXACT []
synonym: "negative regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002516 ! B cell deletion
relationship: negatively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002869
name: positive regulation of B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "activation of B cell deletion" NARROW []
synonym: "positive regulation of B lymphocyte deletion" EXACT []
synonym: "positive regulation of B-cell deletion" EXACT []
synonym: "positive regulation of B-lymphocyte deletion" EXACT []
synonym: "stimulation of B cell deletion" NARROW []
synonym: "up regulation of B cell deletion" EXACT []
synonym: "up-regulation of B cell deletion" EXACT []
synonym: "upregulation of B cell deletion" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002516 ! B cell deletion
relationship: positively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002870
name: T cell anergy
namespace: biological_process
def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149]
synonym: "T lymphocyte anergy" EXACT []
synonym: "T-cell anergy" EXACT []
synonym: "T-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002871
name: regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002519 ! natural killer cell tolerance induction
relationship: regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002872
name: negative regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "down regulation of natural killer cell tolerance induction" EXACT []
synonym: "down-regulation of natural killer cell tolerance induction" EXACT []
synonym: "downregulation of natural killer cell tolerance induction" EXACT []
synonym: "inhibition of natural killer cell tolerance induction" NARROW []
synonym: "negative regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002519 ! natural killer cell tolerance induction
relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002873
name: positive regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "activation of natural killer cell tolerance induction" NARROW []
synonym: "positive regulation of NK cell tolerance induction" EXACT []
synonym: "stimulation of natural killer cell tolerance induction" NARROW []
synonym: "up regulation of natural killer cell tolerance induction" EXACT []
synonym: "up-regulation of natural killer cell tolerance induction" EXACT []
synonym: "upregulation of natural killer cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002519 ! natural killer cell tolerance induction
relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002874
name: regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002875
name: negative regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002876
name: positive regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002877
name: regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002878
name: negative regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002879
name: positive regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002880
name: regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002881
name: negative regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002882
name: positive regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002883
name: regulation of hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add]
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002524 ! hypersensitivity
relationship: regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002884
name: negative regulation of hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "down regulation of hypersensitivity" EXACT []
synonym: "down-regulation of hypersensitivity" EXACT []
synonym: "downregulation of hypersensitivity" EXACT []
synonym: "inhibition of hypersensitivity" NARROW []
is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002524 ! hypersensitivity
relationship: negatively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002885
name: positive regulation of hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "activation of hypersensitivity" NARROW []
synonym: "stimulation of hypersensitivity" NARROW []
synonym: "up regulation of hypersensitivity" EXACT []
synonym: "up-regulation of hypersensitivity" EXACT []
synonym: "upregulation of hypersensitivity" EXACT []
is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002524 ! hypersensitivity
relationship: positively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity
relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "down regulation of immunoglobulin mediated immune response" EXACT []
synonym: "down-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "downregulation of immunoglobulin mediated immune response" EXACT []
synonym: "inhibition of immunoglobulin mediated immune response" NARROW []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "activation of immunoglobulin mediated immune response" NARROW []
synonym: "stimulation of immunoglobulin mediated immune response" NARROW []
synonym: "up regulation of immunoglobulin mediated immune response" EXACT []
synonym: "up-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "upregulation of immunoglobulin mediated immune response" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0016064 ! immunoglobulin mediated immune response
relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002892
name: regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002445 ! type II hypersensitivity
relationship: regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002893
name: negative regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "down regulation of type II hypersensitivity" EXACT []
synonym: "down-regulation of type II hypersensitivity" EXACT []
synonym: "downregulation of type II hypersensitivity" EXACT []
synonym: "inhibition of type II hypersensitivity" NARROW []
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002445 ! type II hypersensitivity
relationship: negatively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002894
name: positive regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "activation of type II hypersensitivity" NARROW []
synonym: "stimulation of type II hypersensitivity" NARROW []
synonym: "up regulation of type II hypersensitivity" EXACT []
synonym: "up-regulation of type II hypersensitivity" EXACT []
synonym: "upregulation of type II hypersensitivity" EXACT []
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002445 ! type II hypersensitivity
relationship: positively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002895
name: regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
is_a: GO:0002646 ! regulation of central tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002510 ! central B cell tolerance induction
relationship: regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002896
name: negative regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "down regulation of central B cell tolerance induction" EXACT []
synonym: "down-regulation of central B cell tolerance induction" EXACT []
synonym: "downregulation of central B cell tolerance induction" EXACT []
synonym: "inhibition of central B cell tolerance induction" NARROW []
is_a: GO:0002647 ! negative regulation of central tolerance induction
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002510 ! central B cell tolerance induction
relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002897
name: positive regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "activation of central B cell tolerance induction" NARROW []
synonym: "stimulation of central B cell tolerance induction" NARROW []
synonym: "up regulation of central B cell tolerance induction" EXACT []
synonym: "up-regulation of central B cell tolerance induction" EXACT []
synonym: "upregulation of central B cell tolerance induction" EXACT []
is_a: GO:0002648 ! positive regulation of central tolerance induction
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002510 ! central B cell tolerance induction
relationship: positively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002898
name: regulation of central B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add]
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002342 ! central B cell deletion
relationship: regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002899
name: negative regulation of central B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "down regulation of central B cell deletion" EXACT []
synonym: "down-regulation of central B cell deletion" EXACT []
synonym: "downregulation of central B cell deletion" EXACT []
synonym: "inhibition of central B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002898 ! regulation of central B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002342 ! central B cell deletion
relationship: negatively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002900
name: positive regulation of central B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "activation of central B cell deletion" NARROW []
synonym: "stimulation of central B cell deletion" NARROW []
synonym: "up regulation of central B cell deletion" EXACT []
synonym: "up-regulation of central B cell deletion" EXACT []
synonym: "upregulation of central B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002898 ! regulation of central B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002342 ! central B cell deletion
relationship: positively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002901
name: mature B cell apoptotic process
namespace: biological_process
def: "The process of apoptosis in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]
synonym: "apoptosis of mature B cells" EXACT []
synonym: "apoptosis of mature B lymphocytes" EXACT []
synonym: "apoptosis of mature B-cells" EXACT []
synonym: "apoptosis of mature B-lymphocytes" EXACT []
synonym: "mature B cell apoptosis" NARROW []
synonym: "mature B cell programmed cell death by apoptosis" EXACT []
synonym: "mature B lymphocyte apoptosis" EXACT []
synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "mature B-cell apoptosis" EXACT []
synonym: "mature B-cell programmed cell death by apoptosis" EXACT []
synonym: "mature B-lymphocyte apoptosis" EXACT []
synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of mature B cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of mature B-cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, mature B cells" EXACT []
synonym: "programmed cell death, mature B lymphocytes" EXACT []
synonym: "programmed cell death, mature B-cells" EXACT []
synonym: "programmed cell death, mature B-lymphocytes" EXACT []
is_a: GO:0001783 ! B cell apoptotic process
relationship: part_of GO:0001782 ! B cell homeostasis

[Term]
id: GO:0002902
name: regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell apoptosis." [GOC:add]
synonym: "regulation of B cell apoptosis" NARROW []
is_a: GO:0070228 ! regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0001783 ! B cell apoptotic process
relationship: regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002903
name: negative regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]
synonym: "down regulation of B cell apoptosis" EXACT []
synonym: "down-regulation of B cell apoptosis" EXACT []
synonym: "downregulation of B cell apoptosis" EXACT []
synonym: "inhibition of B cell apoptosis" NARROW []
synonym: "negative regulation of B cell apoptosis" NARROW []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0001783 ! B cell apoptotic process
relationship: negatively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002904
name: positive regulation of B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptosis." [GOC:add]
synonym: "activation of B cell apoptosis" NARROW []
synonym: "positive regulation of B cell apoptosis" NARROW []
synonym: "stimulation of B cell apoptosis" NARROW []
synonym: "up regulation of B cell apoptosis" EXACT []
synonym: "up-regulation of B cell apoptosis" EXACT []
synonym: "upregulation of B cell apoptosis" EXACT []
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0001783 ! B cell apoptotic process
relationship: positively_regulates GO:0001783 ! B cell apoptotic process

[Term]
id: GO:0002905
name: regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
synonym: "regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptotic process
is_a: GO:0032844 ! regulation of homeostatic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002901 ! mature B cell apoptotic process
relationship: regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002906
name: negative regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
synonym: "down regulation of mature B cell apoptosis" EXACT []
synonym: "down-regulation of mature B cell apoptosis" EXACT []
synonym: "downregulation of mature B cell apoptosis" EXACT []
synonym: "inhibition of mature B cell apoptosis" NARROW []
synonym: "negative regulation of mature B cell apoptosis" NARROW []
is_a: GO:0002903 ! negative regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002901 ! mature B cell apoptotic process
relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002907
name: positive regulation of mature B cell apoptotic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
synonym: "activation of mature B cell apoptosis" NARROW []
synonym: "positive regulation of mature B cell apoptosis" NARROW []
synonym: "stimulation of mature B cell apoptosis" NARROW []
synonym: "up regulation of mature B cell apoptosis" EXACT []
synonym: "up-regulation of mature B cell apoptosis" EXACT []
synonym: "upregulation of mature B cell apoptosis" EXACT []
is_a: GO:0002904 ! positive regulation of B cell apoptotic process
is_a: GO:0002905 ! regulation of mature B cell apoptotic process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002901 ! mature B cell apoptotic process
relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process

[Term]
id: GO:0002908
name: regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002867 ! regulation of B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002454 ! peripheral B cell deletion
relationship: regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002909
name: negative regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "down regulation of peripheral B cell deletion" EXACT []
synonym: "down-regulation of peripheral B cell deletion" EXACT []
synonym: "downregulation of peripheral B cell deletion" EXACT []
synonym: "inhibition of peripheral B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002454 ! peripheral B cell deletion
relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002910
name: positive regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "activation of peripheral B cell deletion" NARROW []
synonym: "stimulation of peripheral B cell deletion" NARROW []
synonym: "up regulation of peripheral B cell deletion" EXACT []
synonym: "up-regulation of peripheral B cell deletion" EXACT []
synonym: "upregulation of peripheral B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002454 ! peripheral B cell deletion
relationship: positively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002911
name: regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002249 ! lymphocyte anergy
relationship: regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002912
name: negative regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "down regulation of lymphocyte anergy" EXACT []
synonym: "down-regulation of lymphocyte anergy" EXACT []
synonym: "downregulation of lymphocyte anergy" EXACT []
synonym: "inhibition of lymphocyte anergy" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002249 ! lymphocyte anergy
relationship: negatively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002913
name: positive regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "activation of lymphocyte anergy" NARROW []
synonym: "stimulation of lymphocyte anergy" NARROW []
synonym: "up regulation of lymphocyte anergy" EXACT []
synonym: "up-regulation of lymphocyte anergy" EXACT []
synonym: "upregulation of lymphocyte anergy" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002249 ! lymphocyte anergy
relationship: positively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002914
name: regulation of central B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add]
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002341 ! central B cell anergy
relationship: regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002915
name: negative regulation of central B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "down regulation of central B cell anergy" EXACT []
synonym: "down-regulation of central B cell anergy" EXACT []
synonym: "downregulation of central B cell anergy" EXACT []
synonym: "inhibition of central B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002914 ! regulation of central B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002341 ! central B cell anergy
relationship: negatively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002916
name: positive regulation of central B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "activation of central B cell anergy" NARROW []
synonym: "stimulation of central B cell anergy" NARROW []
synonym: "up regulation of central B cell anergy" EXACT []
synonym: "up-regulation of central B cell anergy" EXACT []
synonym: "upregulation of central B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002914 ! regulation of central B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002341 ! central B cell anergy
relationship: positively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002917
name: regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002712 ! regulation of B cell mediated immunity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002453 ! peripheral B cell anergy
relationship: regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002918
name: negative regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "down regulation of peripheral B cell anergy" EXACT []
synonym: "down-regulation of peripheral B cell anergy" EXACT []
synonym: "downregulation of peripheral B cell anergy" EXACT []
synonym: "inhibition of peripheral B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002917 ! regulation of peripheral B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002453 ! peripheral B cell anergy
relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002919
name: positive regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "activation of peripheral B cell anergy" NARROW []
synonym: "stimulation of peripheral B cell anergy" NARROW []
synonym: "up regulation of peripheral B cell anergy" EXACT []
synonym: "up-regulation of peripheral B cell anergy" EXACT []
synonym: "upregulation of peripheral B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002917 ! regulation of peripheral B cell anergy
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002453 ! peripheral B cell anergy
relationship: positively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002920
name: regulation of humoral immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0006959 ! humoral immune response
relationship: regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002921
name: negative regulation of humoral immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "down regulation of humoral immune response" EXACT []
synonym: "down-regulation of humoral immune response" EXACT []
synonym: "downregulation of humoral immune response" EXACT []
synonym: "inhibition of humoral immune response" NARROW []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050777 ! negative regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0006959 ! humoral immune response
relationship: negatively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002922
name: positive regulation of humoral immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "activation of humoral immune response" NARROW []
synonym: "stimulation of humoral immune response" NARROW []
synonym: "up regulation of humoral immune response" EXACT []
synonym: "up-regulation of humoral immune response" EXACT []
synonym: "upregulation of humoral immune response" EXACT []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050778 ! positive regulation of immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0006959 ! humoral immune response
relationship: positively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002923
name: regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0002920 ! regulation of humoral immune response
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002924
name: negative regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW []
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002925
name: positive regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin
relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002926
name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.
namespace: biological_process
def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988]
synonym: "mcm5s2U34 biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
created_by: hjd
creation_date: 2012-01-17T02:50:54Z

[Term]
id: GO:0002927
name: archaeosine-tRNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, a an archaea-specific modified base found at position 15 in the in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393]
comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine.
is_a: GO:0006400 ! tRNA modification
created_by: hjd
creation_date: 2012-01-18T03:06:27Z

[Term]
id: GO:0002929
name: MECO complex
namespace: cellular_component
def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642]
synonym: "meta-coactivator complex" EXACT []
is_a: GO:0043234 ! protein complex
relationship: has_part GO:0005671 ! Ada2/Gcn5/Ada3 transcription activator complex
relationship: has_part GO:0016592 ! mediator complex
created_by: hjd
creation_date: 2012-03-14T02:50:13Z

[Term]
id: GO:0002930
name: trabecular meshwork development
namespace: biological_process
def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: hjd
creation_date: 2012-04-19T04:50:06Z

[Term]
id: GO:0002931
name: response to ischemia
namespace: biological_process
def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd]
comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia .
is_a: GO:0006950 ! response to stress
created_by: hjd
creation_date: 2012-04-20T02:57:51Z

[Term]
id: GO:0002932
name: tendon sheath development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0035989 ! tendon development
created_by: hjd
creation_date: 2012-04-23T02:11:22Z

[Term]
id: GO:0002933
name: lipid hydroxylation
namespace: biological_process
def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937]
synonym: "fatty acid hydroxylation" RELATED []
is_a: GO:0030258 ! lipid modification
created_by: hjd
creation_date: 2012-04-24T02:26:33Z

[Term]
id: GO:0002934
name: desmosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd]
is_a: GO:0045216 ! cell-cell junction organization
created_by: hjd
creation_date: 2012-05-08T02:59:08Z

[Term]
id: GO:0003001
name: generation of a signal involved in cell-cell signaling
namespace: biological_process
def: "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph]
synonym: "formation of a signal" BROAD []
synonym: "generation of a signal involved in cell-cell signalling" EXACT []
synonym: "signal generation" BROAD []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003003
name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
namespace: biological_process
def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048165 ! fused antrum stage
relationship: part_of GO:0048165 ! fused antrum stage

[Term]
id: GO:0003004
name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048164 ! distinct antral spaces stage
relationship: part_of GO:0048164 ! distinct antral spaces stage

[Term]
id: GO:0003005
name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
namespace: biological_process
def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
intersection_of: part_of GO:0048163 ! scattered antral spaces stage
relationship: part_of GO:0048163 ! scattered antral spaces stage

[Term]
id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process
intersection_of: GO:0032502 ! developmental process
intersection_of: part_of GO:0000003 ! reproduction

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0003010
name: voluntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003011
name: involuntary skeletal muscle contraction
namespace: biological_process
def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
subset: goslim_generic
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003014
name: renal system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:cjm, GOC:mtg_cardio]
synonym: "excretory system process" EXACT []
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
alt_id: GO:0010802
def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "respiratory gaseous exchange by respiratory system" EXACT []
is_a: GO:0003008 ! system process
is_a: GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0003017
name: lymph circulation
namespace: biological_process
def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio]
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003018
name: vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio]
synonym: "vasculature process" EXACT []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003019
name: central nervous system control of baroreceptor feedback
namespace: biological_process
def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0070483 ! detection of hypoxia
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003021
name: detection of increased carbon dioxide by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003022
name: detection of pH by chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]
synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003030 ! detection of hydrogen ion
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003023
name: baroreceptor detection of increased arterial stretch
namespace: biological_process
def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0003024
name: baroreceptor detection of decreased arterial stretch
namespace: biological_process
def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
namespace: biological_process
def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003026
name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah]
synonym: "vagal reflex" BROAD []
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003028
name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph]
synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003030
name: detection of hydrogen ion
namespace: biological_process
def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003031
name: detection of carbon dioxide
namespace: biological_process
def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003033
name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003034
name: detection of increased carbon dioxide by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003035
name: detection of increased carbon dioxide by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003036
name: detection of pH by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003037
name: detection of pH by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003038
name: detection of reduced oxygen by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003040
name: excitation of vasomotor center by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003041
name: excitation of vasomotor center by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003042
name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951]
synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003043
name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio]
synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003045
name: regulation of systemic arterial blood pressure by physical factors
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by physical factors" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003046
name: regulation of systemic arterial blood pressure by stress relaxation
namespace: biological_process
def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by stress relaxation" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0003047
name: regulation of systemic arterial blood pressure by epinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by epinephrine" RELATED []
synonym: "regulation of blood pressure by adrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003048
name: regulation of systemic arterial blood pressure by norepinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by norepinephrine" RELATED []
synonym: "regulation of blood pressure by noradrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003049
name: regulation of systemic arterial blood pressure by capillary fluid shift
namespace: biological_process
def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949]
synonym: "blood pressure regulation by capillary fluid shift" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors

[Term]
id: GO:0003050
name: regulation of systemic arterial blood pressure by atrial natriuretic peptide
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio]
synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio]
synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003051
name: angiotensin-mediated drinking behavior
namespace: biological_process
def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio]
synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042756 ! drinking behavior
relationship: part_of GO:0002035 ! brain renin-angiotensin system

[Term]
id: GO:0003052
name: circadian regulation of systemic arterial blood pressure
namespace: biological_process
def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003053
name: circadian regulation of heart rate
namespace: biological_process
def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate" RELATED []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003054
name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "master pacemaker clock regulation of blood pressure" EXACT []
synonym: "SCN regulation of blood pressure" EXACT []
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003055
name: circadian regulation of heart rate by the suprachiasmatic nucleus
namespace: biological_process
def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED []
synonym: "master pacemaker clock regulation of heart rate" EXACT []
synonym: "SCN regulation of heart rate" EXACT []
is_a: GO:0003053 ! circadian regulation of heart rate

[Term]
id: GO:0003056
name: regulation of vascular smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0019229 ! regulation of vasoconstriction
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction
relationship: regulates GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0003057
name: regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl]
synonym: "chemical cardiac inotropy" EXACT []
synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0003058
name: hormonal regulation of the force of heart contraction
namespace: biological_process
def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac inotropy" EXACT []
synonym: "hormonal regulation of the force of heart muscle contraction" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal

[Term]
id: GO:0003059
name: positive regulation of the force of heart contraction by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac inotropy" EXACT []
synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac inotropy" EXACT []
synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003060
name: negative regulation of the force of heart contraction by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "decreased force of heart contraction by acetylcholine" EXACT []
is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003061
name: positive regulation of the force of heart contraction by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl]
synonym: "increased force of heart contraction by adrenaline" RELATED []
synonym: "increased force of heart contraction by norepinephrine" EXACT []
synonym: "noradrenaline cardiac inotropy" EXACT []
synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac inotropy" EXACT []
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003062
name: regulation of heart rate by chemical signal
namespace: biological_process
def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]
synonym: "chemical cardiac chronotropy" EXACT []
synonym: "chemical signal regulation of heart contraction rate" RELATED []
synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate

[Term]
id: GO:0003063
name: negative regulation of heart rate by acetylcholine
namespace: biological_process
def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003064
name: regulation of heart rate by hormone
namespace: biological_process
def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac chronotropy" EXACT []
synonym: "regulation of the rate of heart contraction by hormone" EXACT [GOC:curators]
is_a: GO:0003062 ! regulation of heart rate by chemical signal

[Term]
id: GO:0003065
name: positive regulation of heart rate by epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac chronotropy" EXACT []
synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003066
name: positive regulation of heart rate by norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "noradrenaline cardiac chronotropy" EXACT []
synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003067
name: circadian regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003068
name: regulation of systemic arterial blood pressure by acetylcholine
namespace: biological_process
def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl]
synonym: "blood pressure regulation by acetylcholine" EXACT []
is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter

[Term]
id: GO:0003069
name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003070
name: regulation of systemic arterial blood pressure by neurotransmitter
namespace: biological_process
def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "renal control of blood pressure" EXACT []
synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003014 ! renal system process
intersection_of: GO:0003014 ! renal system process
intersection_of: part_of GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003072
name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio]
synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0003074
name: regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035809

[Term]
id: GO:0003075
name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio]
synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003077
name: negative regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035811

[Term]
id: GO:0003078
name: regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035813

[Term]
id: GO:0003079
name: positive regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035815

[Term]
id: GO:0003080
name: negative regulation of natriuresis
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035814

[Term]
id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
namespace: biological_process
def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by renin-angiotensin" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003082
name: positive regulation of renal output by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0003083
name: negative regulation of renal output by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002019 ! regulation of renal output by angiotensin
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0003084
name: positive regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045777 ! positive regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003085
name: negative regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045776 ! negative regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003086
name: regulation of systemic arterial blood pressure by local renal renin-angiotensin
namespace: biological_process
def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0003087
name: positive regulation of the force of heart contraction by neuronal epinephrine
namespace: biological_process
def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine

[Term]
id: GO:0003088
name: positive regulation of the force of heart contraction by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline" RELATED []
synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine

[Term]
id: GO:0003089
name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003090
name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003091
name: renal water homeostasis
namespace: biological_process
def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio]
synonym: "water homeostasis by the kidney" EXACT []
is_a: GO:0003014 ! renal system process
is_a: GO:0050891 ! multicellular organismal water homeostasis

[Term]
id: GO:0003092
name: renal water retention
namespace: biological_process
def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio]
synonym: "negative regulation of renal water excretion" EXACT []
is_a: GO:0035811 ! negative regulation of urine volume

[Term]
id: GO:0003093
name: regulation of glomerular filtration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0044057 ! regulation of system process
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003094 ! glomerular filtration
relationship: regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003094
name: glomerular filtration
namespace: biological_process
def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]
is_a: GO:0097205 ! renal filtration

[Term]
id: GO:0003095
name: pressure natriuresis
namespace: biological_process
def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003096
name: renal sodium ion transport
namespace: biological_process
def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport

[Term]
id: GO:0003097
name: renal water transport
namespace: biological_process
def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006833 ! water transport
relationship: part_of GO:0003091 ! renal water homeostasis

[Term]
id: GO:0003098
name: tubuloglomerular feedback
namespace: biological_process
def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio]
xref: Wikipedia:Tubuloglomerular_feedback
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
relationship: part_of GO:0003093 ! regulation of glomerular filtration

[Term]
id: GO:0003099
name: positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0003100
name: regulation of systemic arterial blood pressure by endothelin
namespace: biological_process
def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003101
name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
namespace: biological_process
def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003102
name: positive regulation of diuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003103
name: positive regulation of diuresis
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0035810

[Term]
id: GO:0003104
name: positive regulation of glomerular filtration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003094 ! glomerular filtration
relationship: positively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003105
name: negative regulation of glomerular filtration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003094 ! glomerular filtration
relationship: negatively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003106
name: negative regulation of glomerular filtration by angiotensin
namespace: biological_process
def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb]
synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of glomerular filtration by angiotensin" BROAD []
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
relationship: part_of GO:0003105 ! negative regulation of glomerular filtration

[Term]
id: GO:0003107
name: positive regulation of natriuresis by angiotensin
namespace: biological_process
def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb]
comment: This term was made obsolete because the term is misleading.
synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb]
is_obsolete: true

[Term]
id: GO:0003108
name: negative regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0003109
name: positive regulation of the force of heart contraction by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating noradrenaline" RELATED []
synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003110
name: positive regulation of the force of heart contraction by neuronal norepinephrine
namespace: biological_process
def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003111
name: positive regulation of heart rate by circulating epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003112
name: positive regulation of heart rate by neuronal epinephrine
namespace: biological_process
def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003113
name: positive regulation of heart rate by neuronal norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003114
name: positive regulation of heart rate by circulating norepinephrine
namespace: biological_process
def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003115
name: regulation of vasoconstriction by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003116
name: regulation of vasoconstriction by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003117
name: regulation of vasoconstriction by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003118
name: regulation of vasoconstriction by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003119
name: regulation of vasoconstriction by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003120
name: regulation of vasoconstriction by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003121
name: regulation of vasodilation by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by adrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003122
name: regulation of vasodilation by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by noradrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003123
name: regulation of vasodilation by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003124
name: regulation of vasodilation by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003125
name: regulation of vasodilation by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003126
name: regulation of vasodilation by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003127
name: detection of nodal flow
namespace: biological_process
def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart]
is_a: GO:0009726 ! detection of endogenous stimulus
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: tanyaberardini
creation_date: 2009-09-22T02:45:48Z

[Term]
id: GO:0003128
name: heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0060914 ! heart formation
created_by: tanyaberardini
creation_date: 2009-09-22T02:56:05Z

[Term]
id: GO:0003129
name: heart induction
namespace: biological_process
def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart]
is_a: GO:0001759 ! organ induction
is_a: GO:2000826 ! regulation of heart morphogenesis
relationship: positively_regulates GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T02:58:41Z

[Term]
id: GO:0003130
name: BMP signaling pathway involved in heart induction
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart]
synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:02:00Z

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: tanyaberardini
creation_date: 2009-09-22T03:07:34Z

[Term]
id: GO:0003132
name: mesodermal-endodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003131 ! mesodermal-endodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
intersection_of: GO:0003131 ! mesodermal-endodermal cell signaling
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:08:52Z

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
created_by: tanyaberardini
creation_date: 2009-09-22T03:10:29Z

[Term]
id: GO:0003134
name: endodermal-mesodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart]
synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah]
is_a: GO:0003133 ! endodermal-mesodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment
intersection_of: GO:0003133 ! endodermal-mesodermal cell signaling
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:11:17Z

[Term]
id: GO:0003135
name: fibroblast growth factor receptor signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development
intersection_of: GO:0008543 ! fibroblast growth factor receptor signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:17:49Z

[Term]
id: GO:0003136
name: negative regulation of heart induction by canonical Wnt receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]
synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling
is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development
is_a: GO:0090381 ! regulation of heart induction
intersection_of: GO:0060070 ! canonical Wnt receptor signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: negatively_regulates GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:26:17Z

[Term]
id: GO:0003137
name: Notch signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart]
synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah]
is_a: GO:0061314 ! Notch signaling involved in heart development
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0003129 ! heart induction
relationship: part_of GO:0003129 ! heart induction
created_by: tanyaberardini
creation_date: 2009-09-22T03:28:42Z

[Term]
id: GO:0003138
name: primary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube." [GOC:mtg_heart]
is_a: GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T03:47:24Z

[Term]
id: GO:0003139
name: secondary heart field specification
namespace: biological_process
def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial and venous poles." [GOC:mtg_heart]
synonym: "anterior heart field specification" NARROW [GOC:mtg_heart]
synonym: "second heart field specification" EXACT [GOC:mtg_heart]
is_a: GO:0003128 ! heart field specification
created_by: tanyaberardini
creation_date: 2009-09-22T03:47:56Z

[Term]
id: GO:0003140
name: determination of left/right asymmetry in lateral mesoderm
namespace: biological_process
def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048368 ! lateral mesoderm development
created_by: tanyaberardini
creation_date: 2009-09-22T03:58:29Z

[Term]
id: GO:0003141
name: transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart]
comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm.
synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT []
is_obsolete: true
replaced_by: GO:1900164
created_by: tanyaberardini
creation_date: 2009-09-22T04:03:22Z

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T04:12:18Z

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: tanyaberardini
creation_date: 2009-09-22T04:21:17Z

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T04:22:34Z

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation
created_by: tanyaberardini
creation_date: 2009-09-22T04:26:03Z

[Term]
id: GO:0003146
name: heart jogging
namespace: biological_process
def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285]
synonym: "cardiac jogging" EXACT [GOC:mtg_heart]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis
relationship: part_of GO:0061371 ! determination of heart left/right asymmetry
created_by: tanyaberardini
creation_date: 2009-09-22T06:11:41Z

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
intersection_of: GO:0001755 ! neural crest cell migration
intersection_of: part_of GO:0060914 ! heart formation
relationship: part_of GO:0060914 ! heart formation
relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development
created_by: tanyaberardini
creation_date: 2009-09-22T04:29:55Z

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:51:01Z

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:51:41Z

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:53:28Z

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: tanyaberardini
creation_date: 2009-09-22T07:59:24Z

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: GO:0060571 ! morphogenesis of an epithelial fold
intersection_of: part_of GO:0003144 ! embryonic heart tube formation
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tanyaberardini
creation_date: 2009-09-23T10:10:24Z

[Term]
id: GO:0003153
name: closure of embryonic heart tube
namespace: biological_process
def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding
created_by: tanyaberardini
creation_date: 2009-09-23T10:14:54Z

[Term]
id: GO:0003154
name: BMP signaling pathway involved in determination of left/right symmetry
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling]
synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0007368 ! determination of left/right symmetry
created_by: tanyaberardini
creation_date: 2009-09-24T05:34:57Z

[Term]
id: GO:0003155
name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart]
synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT []
synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah]
is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm
created_by: tanyaberardini
creation_date: 2009-09-24T05:42:17Z

[Term]
id: GO:0003156
name: regulation of organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048645 ! organ formation
relationship: regulates GO:0048645 ! organ formation
created_by: tanyaberardini
creation_date: 2009-09-30T11:21:09Z

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-01T12:42:27Z

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities,and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0009888 ! tissue development
created_by: dph
creation_date: 2009-10-01T12:50:57Z

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0003158 ! endothelium development
created_by: dph
creation_date: 2009-10-01T01:34:06Z

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003157 ! endocardium development
created_by: dph
creation_date: 2009-10-01T01:37:26Z

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-01T01:57:16Z

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:05:13Z

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:06:09Z

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development
created_by: dph
creation_date: 2009-10-01T02:07:12Z

[Term]
id: GO:0003165
name: cardiac Purkinje fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac Purkinje fiber over time, from its formation to the mature structure. The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003164 ! His-Purkinje system development
created_by: dph
creation_date: 2009-10-01T02:07:50Z

[Term]
id: GO:0003166
name: bundle of His development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003164 ! His-Purkinje system development
created_by: dph
creation_date: 2009-10-01T02:08:43Z

[Term]
id: GO:0003167
name: atrioventricular bundle cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003166 ! bundle of His development
created_by: dph
creation_date: 2009-10-01T02:48:23Z

[Term]
id: GO:0003168
name: cardiac Purkinje fiber cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac Purkinje fiber cell. These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003165 ! cardiac Purkinje fiber development
created_by: dph
creation_date: 2009-10-01T02:49:54Z

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-08T10:45:41Z

[Term]
id: GO:0003170
name: heart valve development
namespace: biological_process
def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]
synonym: "cardiac valve development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-08T10:50:09Z

[Term]
id: GO:0003171
name: atrioventricular valve development
namespace: biological_process
def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "AV valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:14:21Z

[Term]
id: GO:0003172
name: sinoatrial valve development
namespace: biological_process
def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "SA valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:15:39Z

[Term]
id: GO:0003173
name: ventriculo bulbo valve development
namespace: biological_process
def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:16:25Z

[Term]
id: GO:0003174
name: mitral valve development
namespace: biological_process
def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:17:22Z

[Term]
id: GO:0003175
name: tricuspid valve development
namespace: biological_process
def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:18:12Z

[Term]
id: GO:0003176
name: aortic valve development
namespace: biological_process
def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:18:55Z

[Term]
id: GO:0003177
name: pulmonary valve development
namespace: biological_process
def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:19:44Z

[Term]
id: GO:0003178
name: coronary sinus valve development
namespace: biological_process
def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:21:43Z

[Term]
id: GO:0003179
name: heart valve morphogenesis
namespace: biological_process
def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart]
synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf]
synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-08T11:23:48Z

[Term]
id: GO:0003180
name: aortic valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003176 ! aortic valve development
created_by: dph
creation_date: 2009-10-08T11:29:42Z

[Term]
id: GO:0003181
name: atrioventricular valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart]
synonym: "AV valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003171 ! atrioventricular valve development
created_by: dph
creation_date: 2009-10-08T11:31:59Z

[Term]
id: GO:0003182
name: coronary sinus valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003178 ! coronary sinus valve development
created_by: dph
creation_date: 2009-10-08T11:33:31Z

[Term]
id: GO:0003183
name: mitral valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003174 ! mitral valve development
created_by: dph
creation_date: 2009-10-08T12:02:01Z

[Term]
id: GO:0003184
name: pulmonary valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003177 ! pulmonary valve development
created_by: dph
creation_date: 2009-10-08T12:03:35Z

[Term]
id: GO:0003185
name: sinoatrial valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart]
synonym: "SA valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003172 ! sinoatrial valve development
created_by: dph
creation_date: 2009-10-08T12:04:52Z

[Term]
id: GO:0003186
name: tricuspid valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003175 ! tricuspid valve development
created_by: dph
creation_date: 2009-10-08T12:05:45Z

[Term]
id: GO:0003187
name: ventriculo bulbo valve morphogenesis
namespace: biological_process
def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003173 ! ventriculo bulbo valve development
created_by: dph
creation_date: 2009-10-08T12:07:00Z

[Term]
id: GO:0003188
name: heart valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-08T12:20:15Z

[Term]
id: GO:0003189
name: aortic valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003180 ! aortic valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:05:44Z

[Term]
id: GO:0003190
name: atrioventricular valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "AV valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:07:28Z

[Term]
id: GO:0003191
name: coronary sinus valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:09:04Z

[Term]
id: GO:0003192
name: mitral valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003183 ! mitral valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:10:19Z

[Term]
id: GO:0003193
name: pulmonary valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003184 ! pulmonary valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:11:20Z

[Term]
id: GO:0003194
name: sinoatrial valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "SA valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:12:45Z

[Term]
id: GO:0003195
name: tricuspid valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003186 ! tricuspid valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:14:40Z

[Term]
id: GO:0003196
name: ventriculo bulbo valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis
created_by: dph
creation_date: 2009-10-08T01:16:02Z

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-08T01:17:43Z

[Term]
id: GO:0003198
name: epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: GO:0001837 ! epithelial to mesenchymal transition
intersection_of: part_of GO:0003272 ! endocardial cushion formation
relationship: part_of GO:0003272 ! endocardial cushion formation
created_by: dph
creation_date: 2009-10-08T01:27:42Z

[Term]
id: GO:0003199
name: endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart]
synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003188 ! heart valve formation
created_by: dph
creation_date: 2009-10-08T01:31:21Z

[Term]
id: GO:0003200
name: endocardial cushion to mesenchymal transition involved in heart chamber septation
namespace: biological_process
def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060411 ! cardiac septum morphogenesis
created_by: dph
creation_date: 2009-10-08T01:34:31Z

[Term]
id: GO:0003201
name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
intersection_of: GO:0001837 ! epithelial to mesenchymal transition
intersection_of: part_of GO:0060977 ! coronary vasculature morphogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis
created_by: dph
creation_date: 2009-10-08T01:36:54Z

[Term]
id: GO:0003202
name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003204 ! cardiac skeleton development
created_by: dph
creation_date: 2009-10-08T01:39:57Z

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development
created_by: dph
creation_date: 2009-10-08T01:43:22Z

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0061448 ! connective tissue development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-13T09:05:04Z

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-13T09:11:18Z

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T09:14:51Z

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
created_by: dph
creation_date: 2009-10-13T09:29:13Z

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003231 ! cardiac ventricle development
created_by: dph
creation_date: 2009-10-13T09:38:44Z

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003230 ! cardiac atrium development
created_by: dph
creation_date: 2009-10-13T09:39:44Z

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:44:25Z

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:46:27Z

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:48:16Z

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:49:03Z

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:50:08Z

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:50:57Z

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:52:31Z

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis
created_by: dph
creation_date: 2009-10-13T09:53:12Z

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:54:33Z

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T09:55:38Z

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T10:18:05Z

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T10:26:33Z

[Term]
id: GO:0003222
name: ventricular trabecula myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
is_a: GO:0061384 ! heart trabecula morphogenesis
created_by: dph
creation_date: 2009-10-13T10:33:00Z

[Term]
id: GO:0003223
name: ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2009-10-13T10:34:21Z

[Term]
id: GO:0003224
name: left ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:43:36Z

[Term]
id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:45:09Z

[Term]
id: GO:0003226
name: right ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:48:42Z

[Term]
id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis
created_by: dph
creation_date: 2009-10-13T10:50:59Z

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
created_by: dph
creation_date: 2009-10-13T10:53:18Z

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development
created_by: dph
creation_date: 2009-10-13T10:56:01Z

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:02:07Z

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:03:16Z

[Term]
id: GO:0003232
name: bulbus arteriosus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:05:36Z

[Term]
id: GO:0003233
name: bulbus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003232 ! bulbus arteriosus development
created_by: dph
creation_date: 2009-10-13T11:07:30Z

[Term]
id: GO:0003234
name: bulbus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:10:02Z

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:12:34Z

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003235 ! sinus venosus development
created_by: dph
creation_date: 2009-10-13T11:16:52Z

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003236 ! sinus venosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:18:34Z

[Term]
id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-13T11:20:57Z

[Term]
id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003238 ! conus arteriosus development
created_by: dph
creation_date: 2009-10-13T11:25:04Z

[Term]
id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003239 ! conus arteriosus morphogenesis
created_by: dph
creation_date: 2009-10-13T11:25:47Z

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
intersection_of: GO:0040007 ! growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0060419 ! heart growth
created_by: dph
creation_date: 2009-10-13T11:28:46Z

[Term]
id: GO:0003242
name: cardiac chamber ballooning
namespace: biological_process
def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
created_by: dph
creation_date: 2009-10-13T11:30:30Z

[Term]
id: GO:0003243
name: circumferential growth involved in left ventricle morphogenesis
namespace: biological_process
def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T11:33:09Z

[Term]
id: GO:0003244
name: radial growth involved in right ventricle morphogenesis
namespace: biological_process
def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis
created_by: dph
creation_date: 2009-10-13T11:38:23Z

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
intersection_of: GO:0055017 ! cardiac muscle tissue growth
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis
created_by: dph
creation_date: 2009-10-13T11:44:21Z

[Term]
id: GO:0003246
name: embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart]
synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis
created_by: dph
creation_date: 2009-10-13T11:46:23Z

[Term]
id: GO:0003247
name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis
created_by: dph
creation_date: 2009-10-13T11:50:29Z

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060419 ! heart growth
relationship: part_of GO:0060976 ! coronary vasculature development
created_by: dph
creation_date: 2009-10-13T11:53:12Z

[Term]
id: GO:0003249
name: cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis
is_a: GO:2000793 ! cell proliferation involved in heart valve development
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T01:59:19Z

[Term]
id: GO:0003250
name: regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:03:42Z

[Term]
id: GO:0003251
name: positive regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:07:20Z

[Term]
id: GO:0003252
name: negative regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis
created_by: dph
creation_date: 2009-10-13T02:10:39Z

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-13T02:14:16Z

[Term]
id: GO:0003254
name: regulation of membrane depolarization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:2000021 ! regulation of ion homeostasis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0051899 ! membrane depolarization
relationship: regulates GO:0051899 ! membrane depolarization
created_by: tanyaberardini
creation_date: 2009-10-14T10:54:09Z

[Term]
id: GO:0003255
name: endocardial precursor cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation
created_by: dph
creation_date: 2009-10-15T12:09:43Z

[Term]
id: GO:0003256
name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: dph
creation_date: 2009-10-15T01:01:25Z

[Term]
id: GO:0003257
name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation
created_by: dph
creation_date: 2009-10-15T01:07:25Z

[Term]
id: GO:0003258
name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
intersection_of: part_of GO:0003255 ! endocardial precursor cell differentiation
relationship: part_of GO:0003255 ! endocardial precursor cell differentiation
created_by: dph
creation_date: 2009-10-15T01:10:34Z

[Term]
id: GO:0003259
name: cardioblast anterior-lateral migration
namespace: biological_process
def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration
created_by: dph
creation_date: 2009-10-15T01:17:28Z

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-15T01:52:25Z

[Term]
id: GO:0003261
name: cardiac muscle progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart]
synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation
created_by: dph
creation_date: 2009-10-15T01:57:55Z

[Term]
id: GO:0003262
name: endocardial progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation
created_by: dph
creation_date: 2009-10-15T02:00:41Z

[Term]
id: GO:0003263
name: cardioblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0060914 ! heart formation
created_by: dph
creation_date: 2009-10-15T02:13:05Z

[Term]
id: GO:0003264
name: regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:2000826 ! regulation of heart morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003263 ! cardioblast proliferation
relationship: regulates GO:0003263 ! cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:19:37Z

[Term]
id: GO:0003265
name: regulation of primary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the first heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "regulation of first heart field cardiac proliferation" RELATED []
is_a: GO:0003264 ! regulation of cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:25:26Z

[Term]
id: GO:0003266
name: regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
is_a: GO:0003264 ! regulation of cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:26:15Z

[Term]
id: GO:0003267
name: canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in an increase in the frequency, or rate of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0044340 ! canonical Wnt receptor signaling pathway involved in regulation of cell proliferation
is_a: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development
intersection_of: GO:0061316 ! canonical Wnt receptor signaling pathway involved in heart development
intersection_of: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:36:08Z

[Term]
id: GO:0003268
name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph]
synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf]
synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah]
is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development
intersection_of: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:43:03Z

[Term]
id: GO:0003269
name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:45:28Z

[Term]
id: GO:0003270
name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph]
synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0061314 ! Notch signaling involved in heart development
intersection_of: GO:0007219 ! Notch signaling pathway
intersection_of: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:47:00Z

[Term]
id: GO:0003271
name: smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph]
synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation
created_by: dph
creation_date: 2009-10-15T02:48:32Z

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T08:53:19Z

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0003272 ! endocardial cushion formation
relationship: part_of GO:0003272 ! endocardial cushion formation
created_by: dph
creation_date: 2009-10-20T09:08:44Z

[Term]
id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T09:26:32Z

[Term]
id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart]
synonym: "apoptosis involved in outflow tract morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003151 ! outflow tract morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis
created_by: dph
creation_date: 2009-10-20T09:30:01Z

[Term]
id: GO:0003276
name: apoptotic process involved in heart valve morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of a heart valve." [GOC:mtg_heart]
synonym: "apoptosis involved in heart valve morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis
created_by: dph
creation_date: 2009-10-20T09:34:29Z

[Term]
id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW []
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003203 ! endocardial cushion morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis
created_by: dph
creation_date: 2009-10-20T09:37:03Z

[Term]
id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def: "The process of apoptosis that contributes to the shaping of the heart." [GOC:mtg_heart]
synonym: "apoptosis involved in heart morphogenesis" NARROW []
is_a: GO:0060561 ! apoptotic process involved in morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-20T09:40:22Z

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003205 ! cardiac chamber development
created_by: dph
creation_date: 2009-10-20T09:45:13Z

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003231 ! cardiac ventricle development
created_by: dph
creation_date: 2009-10-20T10:04:51Z

[Term]
id: GO:0003282
name: ventricular septum intermedium development
namespace: biological_process
def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003281 ! ventricular septum development
created_by: dph
creation_date: 2009-10-20T10:09:53Z

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003230 ! cardiac atrium development
created_by: dph
creation_date: 2009-10-20T10:10:38Z

[Term]
id: GO:0003284
name: septum primum development
namespace: biological_process
def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:12:26Z

[Term]
id: GO:0003285
name: septum secundum development
namespace: biological_process
def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:21:13Z

[Term]
id: GO:0003286
name: atrial septum intermedium development
namespace: biological_process
def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development
created_by: dph
creation_date: 2009-10-20T10:23:52Z

[Term]
id: GO:0003288
name: ventricular septum intermedium morphogenesis
namespace: biological_process
def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060412 ! ventricular septum morphogenesis
created_by: dph
creation_date: 2009-10-20T10:58:48Z

[Term]
id: GO:0003289
name: atrial septum primum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003284 ! septum primum development
created_by: dph
creation_date: 2009-10-20T10:32:32Z

[Term]
id: GO:0003290
name: atrial septum secundum morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003285 ! septum secundum development
created_by: dph
creation_date: 2009-10-20T10:33:57Z

[Term]
id: GO:0003291
name: atrial septum intermedium morphogenesis
namespace: biological_process
def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003286 ! atrial septum intermedium development
created_by: dph
creation_date: 2009-10-20T10:35:04Z

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation
relationship: part_of GO:0003279 ! cardiac septum development
created_by: dph
creation_date: 2009-10-20T11:03:46Z

[Term]
id: GO:0003293
name: heart valve cell differentiation
namespace: biological_process
def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation
relationship: part_of GO:0003170 ! heart valve development
created_by: dph
creation_date: 2009-10-20T11:06:46Z

[Term]
id: GO:0003294
name: atrial ventricular junction remodeling
namespace: biological_process
def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart]
synonym: "atrio-ventricular junction remodeling " RELATED [GOC:mtg_heart]
synonym: "atrioventricular junction remodeling " EXACT [GOC:mtg_heart]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-22T08:35:36Z

[Term]
id: GO:0003295
name: cell proliferation involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "cell proliferation involved in atrio-ventricular junction remodeling " EXACT [GOC:mtg_heart]
synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
intersection_of: GO:0008283 ! cell proliferation
intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling
created_by: dph
creation_date: 2009-10-22T08:38:30Z

[Term]
id: GO:0003296
name: apoptotic process involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The process of apoptosis that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW []
synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "apoptosis involved in atrioventricular junction remodeling " EXACT [GOC:mtg_heart]
is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis
intersection_of: GO:0006915 ! apoptotic process
intersection_of: part_of GO:0003294 ! atrial ventricular junction remodeling
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling
created_by: dph
creation_date: 2009-10-22T08:43:11Z

[Term]
id: GO:0003297
name: heart wedging
namespace: biological_process
def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
created_by: dph
creation_date: 2009-10-22T08:52:58Z

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T09:24:51Z

[Term]
id: GO:0003299
name: muscle hypertrophy in response to stress
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]
is_a: GO:0006950 ! response to stress
is_a: GO:0014896 ! muscle hypertrophy
is_a: GO:0043500 ! muscle adaptation
created_by: dph
creation_date: 2009-10-22T09:26:10Z

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy
created_by: dph
creation_date: 2009-10-22T10:33:56Z

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:mtg_heart]
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: part_of GO:0055017 ! cardiac muscle tissue growth
created_by: dph
creation_date: 2009-10-22T10:38:10Z

[Term]
id: GO:0003302
name: transforming growth factor beta receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling]
synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0007179 ! transforming growth factor beta receptor signaling pathway
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T10:51:58Z

[Term]
id: GO:0003303
name: BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart]
synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah]
is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry
is_a: GO:0061312 ! BMP signaling pathway involved in heart development
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:00:58Z

[Term]
id: GO:0003304
name: myocardial epithelial involution involved in heart jogging
namespace: biological_process
def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:03:33Z

[Term]
id: GO:0003305
name: cell migration involved in heart jogging
namespace: biological_process
def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
intersection_of: GO:0016477 ! cell migration
intersection_of: part_of GO:0003146 ! heart jogging
relationship: part_of GO:0003146 ! heart jogging
created_by: dph
creation_date: 2009-10-22T11:05:46Z

[Term]
id: GO:0003306
name: Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0016055 ! Wnt receptor signaling pathway
is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development
intersection_of: GO:0016055 ! Wnt receptor signaling pathway
intersection_of: part_of GO:0007507 ! heart development
created_by: dph
creation_date: 2009-10-22T12:26:07Z

[Term]
id: GO:0003307
name: regulation of Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
is_a: GO:2000026 ! regulation of multicellular organismal development
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development
relationship: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development
created_by: dph
creation_date: 2009-10-22T12:32:10Z

[Term]
id: GO:0003308
name: negative regulation of Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah]
is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development
is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development
relationship: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development
created_by: dph
creation_date: 2009-10-22T12:36:11Z

[Term]
id: GO:0003309
name: type B pancreatic cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772]
synonym: "pancreatic B cell differentiation" EXACT [GOC:mah]
synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:27:23Z

[Term]
id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772]
synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:28:05Z

[Term]
id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772]
synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:30:27Z

[Term]
id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]
synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development
created_by: dph
creation_date: 2009-10-26T09:32:32Z

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0035050 ! embryonic heart tube development
created_by: dph
creation_date: 2009-10-27T08:32:40Z

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0003313 ! heart rudiment development
created_by: dph
creation_date: 2009-10-27T08:38:04Z

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003314 ! heart rudiment morphogenesis
created_by: dph
creation_date: 2009-10-27T08:43:37Z

[Term]
id: GO:0003316
name: establishment of myocardial progenitor cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:01:26Z

[Term]
id: GO:0003317
name: cardioblast cell midline fusion
namespace: biological_process
def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:08:57Z

[Term]
id: GO:0003318
name: cell migration to the midline involved in heart development
namespace: biological_process
def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
created_by: dph
creation_date: 2009-10-27T09:15:43Z

[Term]
id: GO:0003319
name: cardioblast migration to the midline involved in heart rudiment formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart]
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0003315 ! heart rudiment formation
created_by: dph
creation_date: 2009-10-27T09:21:36Z

[Term]
id: GO:0003320
name: heart rudiment involution
namespace: biological_process
def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart]
is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation
created_by: dph
creation_date: 2009-10-27T09:29:24Z

[Term]
id: GO:0003321
name: positive regulation of blood pressure by epinephrine-norepinephrine
namespace: biological_process
def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph]
is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine
is_a: GO:0045777 ! positive regulation of blood pressure
created_by: dph
creation_date: 2009-10-29T01:52:50Z

[Term]
id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
synonym: "pancreatic alpha cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003310 ! pancreatic A cell differentiation
created_by: dph
creation_date: 2009-11-02T08:13:55Z

[Term]
id: GO:0003323
name: type B pancreatic cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell development" EXACT [GOC:mah]
synonym: "pancreatic beta cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation
created_by: dph
creation_date: 2009-11-02T08:20:11Z

[Term]
id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
synonym: "pancreatic delta cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003311 ! pancreatic D cell differentiation
created_by: dph
creation_date: 2009-11-02T08:23:26Z

[Term]
id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation
created_by: dph
creation_date: 2009-11-02T08:25:03Z

[Term]
id: GO:0003326
name: pancreatic A cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003310 ! pancreatic A cell differentiation
created_by: dph
creation_date: 2009-11-02T08:29:00Z

[Term]
id: GO:0003327
name: type B pancreatic cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]
synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003309 ! type B pancreatic cell differentiation
created_by: dph
creation_date: 2009-11-02T08:31:24Z

[Term]
id: GO:0003328
name: pancreatic D cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003311 ! pancreatic D cell differentiation
created_by: dph
creation_date: 2009-11-02T08:33:36Z

[Term]
id: GO:0003329
name: pancreatic PP cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation
created_by: dph
creation_date: 2009-11-02T08:35:13Z

[Term]
id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060341 ! regulation of cellular localization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:07:40Z

[Term]
id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:11:22Z

[Term]
id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion
relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion
created_by: dph
creation_date: 2009-11-02T02:13:49Z

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0055085 ! transmembrane transport
created_by: dph
creation_date: 2009-11-02T02:36:11Z

[Term]
id: GO:0003334
name: keratinocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0030216 ! keratinocyte differentiation
created_by: dph
creation_date: 2009-11-24T08:55:57Z

[Term]
id: GO:0003335
name: corneocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0003334 ! keratinocyte development
created_by: dph
creation_date: 2009-11-24T09:01:02Z

[Term]
id: GO:0003336
name: corneocyte desquamation
namespace: biological_process
def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph]
synonym: "epidermal desquamation" EXACT [GOC:dph]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0003335 ! corneocyte development
created_by: dph
creation_date: 2009-11-24T09:11:53Z

[Term]
id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph]
is_a: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: GO:0060231 ! mesenchymal to epithelial transition
intersection_of: part_of GO:0003338 ! metanephros morphogenesis
relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis
created_by: dph
creation_date: 2009-11-24T09:29:49Z

[Term]
id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001656 ! metanephros development
created_by: dph
creation_date: 2009-11-24T09:32:09Z

[Term]
id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0072215 ! regulation of metanephros development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:43:04Z

[Term]
id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis
created_by: dph
creation_date: 2009-11-24T09:46:12Z

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006928 ! cellular component movement
is_a: GO:0007018 ! microtubule-based movement
created_by: dph
creation_date: 2009-11-24T09:56:26Z

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0003343 ! septum transversum development
created_by: dph
creation_date: 2009-12-01T10:30:17Z

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
created_by: dph
creation_date: 2009-12-01T10:40:17Z

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060039 ! pericardium development
created_by: dph
creation_date: 2009-12-01T10:46:34Z

[Term]
id: GO:0003345
name: proepicardium cell migration involved in pericardium morphogenesis
namespace: biological_process
def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003344 ! pericardium morphogenesis
created_by: dph
creation_date: 2009-12-01T10:49:32Z

[Term]
id: GO:0003346
name: epicardium-derived cell migration to the myocardium
namespace: biological_process
def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development
created_by: dph
creation_date: 2009-12-01T11:00:42Z

[Term]
id: GO:0003347
name: epicardial cell to mesenchymal cell transition
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343]
is_a: GO:0001837 ! epithelial to mesenchymal transition
created_by: dph
creation_date: 2009-12-01T11:05:39Z

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiac cell differentiation
created_by: dph
creation_date: 2009-12-01T11:12:05Z

[Term]
id: GO:0003349
name: epicardium-derived cardiac endothelial cell differentiation
namespace: biological_process
def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
created_by: dph
creation_date: 2009-12-01T11:17:49Z

[Term]
id: GO:0003350
name: pulmonary myocardium development
namespace: biological_process
def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577]
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060841 ! venous blood vessel development
created_by: dph
creation_date: 2009-12-01T12:50:06Z

[Term]
id: GO:0003351
name: epithelial cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph]
synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:08:25Z

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0051270 ! regulation of cellular component movement
is_a: GO:0060632 ! regulation of microtubule-based movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003341 ! cilium movement
relationship: regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:12:00Z

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051272 ! positive regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: positively_regulates GO:0003341 ! cilium movement
relationship: positively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:16:10Z

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051271 ! negative regulation of cellular component movement
intersection_of: GO:0065007 ! biological regulation
intersection_of: negatively_regulates GO:0003341 ! cilium movement
relationship: negatively_regulates GO:0003341 ! cilium movement
created_by: dph
creation_date: 2009-12-03T10:17:47Z

[Term]
id: GO:0003355
name: cilium movement involved in otolith formation
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph]
is_a: GO:0003351 ! epithelial cilium movement
intersection_of: GO:0003341 ! cilium movement
intersection_of: part_of GO:0032475 ! otolith formation
relationship: part_of GO:0032475 ! otolith formation
created_by: dph
creation_date: 2009-12-03T10:21:08Z

[Term]
id: GO:0003356
name: regulation of cilium beat frequency
namespace: biological_process
def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement
created_by: dph
creation_date: 2009-12-03T10:27:12Z

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:34:30Z

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:38:37Z

[Term]
id: GO:0003359
name: noradrenergic neuron fate commitment
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph]
synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation
created_by: dph
creation_date: 2009-12-03T10:41:08Z

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
created_by: dph
creation_date: 2009-12-03T10:47:20Z

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: GO:0003357 ! noradrenergic neuron differentiation
intersection_of: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003360 ! brainstem development
created_by: dph
creation_date: 2009-12-03T10:53:30Z

[Term]
id: GO:0003362
name: noradrenergic neuron fate commitment involved in brainstem development
namespace: biological_process
def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003359 ! noradrenergic neuron fate commitment
intersection_of: GO:0003359 ! noradrenergic neuron fate commitment
intersection_of: part_of GO:0003360 ! brainstem development
relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development
created_by: dph
creation_date: 2009-12-03T10:56:16Z

[Term]
id: GO:0003363
name: lamellipodium assembly involved in ameboidal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030032 ! lamellipodium assembly
intersection_of: GO:0030032 ! lamellipodium assembly
intersection_of: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0001667 ! ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T04:38:04Z

[Term]
id: GO:0003364
name: lamellipodium assembly involved in mesendodermal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T04:46:39Z

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0001667 ! ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T04:50:41Z

[Term]
id: GO:0003366
name: cell-matrix adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007160 ! cell-matrix adhesion
intersection_of: GO:0007160 ! cell-matrix adhesion
intersection_of: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0001667 ! ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T04:54:33Z

[Term]
id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion
intersection_of: GO:0016337 ! cell-cell adhesion
intersection_of: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T05:15:49Z

[Term]
id: GO:0003368
name: cell-matrix adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration
intersection_of: GO:0007160 ! cell-matrix adhesion
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T05:26:12Z

[Term]
id: GO:0003369
name: establishment of cell polarity involved in mesendodermal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration
created_by: dph
creation_date: 2009-12-08T05:31:51Z

[Term]
id: GO:0003370
name: cell-cell adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration
is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration
created_by: dph
creation_date: 2009-12-08T05:33:51Z

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
created_by: dph
creation_date: 2009-12-08T05:42:46Z

[Term]
id: GO:0003372
name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0090134 ! cell migration involved in mesendoderm migration
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration
created_by: dph
creation_date: 2009-12-08T05:46:23Z

[Term]
id: GO:0003373
name: dynamin polymerization involved in membrane fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0090148 ! membrane fission
created_by: dph
creation_date: 2009-12-09T04:55:16Z

[Term]
id: GO:0003374
name: dynamin polymerization involved in mitochondrial fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003373 ! dynamin polymerization involved in membrane fission
created_by: dph
creation_date: 2009-12-09T05:39:52Z

[Term]
id: GO:0003375
name: regulation of dynamin polymerization involved in membrane fission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032271 ! regulation of protein polymerization
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003373 ! dynamin polymerization involved in membrane fission
relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission
created_by: dph
creation_date: 2009-12-09T05:50:15Z

[Term]
id: GO:0003376
name: sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:22001186, Reactome:REACT_18416.2]
comment: Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'.
synonym: "S1P receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P signaling pathway" EXACT [GOC:bf]
synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf]
synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf]
synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186]
synonym: "sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "sphingolipid signalling pathway" BROAD [GOC:mah]
xref: Reactome:REACT_18416.2 "S1P-binding receptors bind S1P"
is_a: GO:0007186 ! G-protein coupled receptor signaling pathway
created_by: dph
creation_date: 2009-12-09T06:30:12Z

[Term]
id: GO:0003377
name: regulation of apoptosis by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb]
synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah]
is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway
is_a: GO:0042981 ! regulation of apoptotic process
created_by: dph
creation_date: 2009-12-09T06:32:22Z

[Term]
id: GO:0003378
name: regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def: "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf]
synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah]
is_a: GO:0003376 ! sphingosine-1-phosphate signaling pathway
is_a: GO:0050727 ! regulation of inflammatory response
intersection_of: GO:0003376 ! sphingosine-1-phosphate signaling pathway
intersection_of: results_in GO:0050727 ! regulation of inflammatory response
created_by: dph
creation_date: 2009-12-09T06:38:06Z

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0042074 ! cell migration involved in gastrulation
created_by: dph
creation_date: 2009-12-09T06:54:44Z

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
created_by: dph
creation_date: 2009-12-09T07:10:57Z

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
intersection_of: GO:0003382 ! epithelial cell morphogenesis
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0007369 ! gastrulation
created_by: dph
creation_date: 2009-12-09T07:18:53Z

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002064 ! epithelial cell development
created_by: dph
creation_date: 2009-12-09T07:21:06Z

[Term]
id: GO:0003383
name: apical constriction
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0003382 ! epithelial cell morphogenesis
created_by: dph
creation_date: 2009-12-09T07:30:34Z

[Term]
id: GO:0003384
name: apical constriction involved in gastrulation
namespace: biological_process
def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003383 ! apical constriction
intersection_of: GO:0003383 ! apical constriction
intersection_of: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation
created_by: dph
creation_date: 2009-12-09T07:35:38Z

[Term]
id: GO:0003385
name: cell-cell signaling involved in amphid sensory organ development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah]
is_a: GO:0007267 ! cell-cell signaling
intersection_of: GO:0007267 ! cell-cell signaling
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T08:55:37Z

[Term]
id: GO:0003386
name: amphid sensory organ development
namespace: biological_process
def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007423 ! sensory organ development
created_by: dph
creation_date: 2009-12-09T09:09:20Z

[Term]
id: GO:0003387
name: neuron differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
intersection_of: GO:0030182 ! neuron differentiation
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:15:00Z

[Term]
id: GO:0003388
name: neuron development involved in amphid sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048666 ! neuron development
intersection_of: GO:0048666 ! neuron development
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:18:06Z

[Term]
id: GO:0003389
name: retrograde extension
namespace: biological_process
def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031175 ! neuron projection development
created_by: dph
creation_date: 2009-12-09T09:22:03Z

[Term]
id: GO:0003390
name: dendrite development by retrograde extension
namespace: biological_process
def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003389 ! retrograde extension
is_a: GO:0016358 ! dendrite development
created_by: dph
creation_date: 2009-12-09T09:25:24Z

[Term]
id: GO:0003391
name: amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:28:27Z

[Term]
id: GO:0003392
name: cell adhesion involved in retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007155 ! cell adhesion
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003389 ! retrograde extension
relationship: part_of GO:0003389 ! retrograde extension
created_by: dph
creation_date: 2009-12-09T09:32:06Z

[Term]
id: GO:0003393
name: neuron migration involved in retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001764 ! neuron migration
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003389 ! retrograde extension
relationship: part_of GO:0003389 ! retrograde extension
created_by: dph
creation_date: 2009-12-09T09:36:03Z

[Term]
id: GO:0003394
name: cell adhesion involved in dendrite retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003392 ! cell adhesion involved in retrograde extension
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension
created_by: dph
creation_date: 2009-12-09T09:42:09Z

[Term]
id: GO:0003395
name: neuron migration involved in dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003393 ! neuron migration involved in retrograde extension
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension
created_by: dph
creation_date: 2009-12-09T09:44:24Z

[Term]
id: GO:0003396
name: cell adhesion involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension
intersection_of: GO:0007155 ! cell adhesion
intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
created_by: dph
creation_date: 2009-12-09T09:50:18Z

[Term]
id: GO:0003397
name: neuron migration involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension
intersection_of: GO:0001764 ! neuron migration
intersection_of: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension
created_by: dph
creation_date: 2009-12-09T09:52:18Z

[Term]
id: GO:0003398
name: glial cell differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010001 ! glial cell differentiation
intersection_of: GO:0010001 ! glial cell differentiation
intersection_of: part_of GO:0003386 ! amphid sensory organ development
relationship: part_of GO:0003386 ! amphid sensory organ development
created_by: dph
creation_date: 2009-12-09T09:55:27Z

[Term]
id: GO:0003399
name: cytoneme morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048858 ! cell projection morphogenesis
created_by: dph
creation_date: 2009-12-09T10:03:32Z

[Term]
id: GO:0003400
name: regulation of COPII vesicle coating
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi
is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0048208 ! COPII vesicle coating
relationship: regulates GO:0048208 ! COPII vesicle coating
created_by: dph
creation_date: 2009-12-17T08:38:14Z

[Term]
id: GO:0003401
name: axis elongation
namespace: biological_process
def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
created_by: dph
creation_date: 2009-12-21T01:12:15Z

[Term]
id: GO:0003402
name: planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
intersection_of: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
intersection_of: part_of GO:0003401 ! axis elongation
relationship: part_of GO:0003401 ! axis elongation
created_by: dph
creation_date: 2009-12-21T01:22:11Z

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
relationship: part_of GO:0060900 ! embryonic camera-type eye formation
created_by: dph
creation_date: 2009-12-21T01:42:37Z

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T01:54:34Z

[Term]
id: GO:0003405
name: optic vesicle elongation
namespace: biological_process
def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
created_by: dph
creation_date: 2009-12-21T01:59:50Z

[Term]
id: GO:0003406
name: retinal pigment epithelium development
namespace: biological_process
def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060041 ! retina development in camera-type eye
created_by: dph
creation_date: 2009-12-21T02:04:27Z

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060041 ! retina development in camera-type eye
created_by: dph
creation_date: 2009-12-21T02:15:14Z

[Term]
id: GO:0003408
name: optic cup formation involved in camera-type eye development
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:37:12Z

[Term]
id: GO:0003409
name: optic cup structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "optic cup structural organisation" EXACT [GOC:mah]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:44:20Z

[Term]
id: GO:0003410
name: anterior rotation of the optic cup
namespace: biological_process
def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development
created_by: dph
creation_date: 2009-12-21T02:49:48Z

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
intersection_of: GO:0048870 ! cell motility
intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T03:04:27Z

[Term]
id: GO:0003412
name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
intersection_of: GO:0045198 ! establishment of epithelial cell apical/basal polarity
intersection_of: part_of GO:0048593 ! camera-type eye morphogenesis
created_by: dph
creation_date: 2009-12-21T03:09:23Z

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
intersection_of: GO:0002062 ! chondrocyte differentiation
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:39:58Z

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
intersection_of: GO:0090171 ! chondrocyte morphogenesis
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:42:55Z

[Term]
id: GO:0003415
name: chondrocyte hypertrophy
namespace: biological_process
def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0002063 ! chondrocyte development
created_by: dph
creation_date: 2009-12-22T08:48:44Z

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T08:52:55Z

[Term]
id: GO:0003417
name: growth plate cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
relationship: part_of GO:0003416 ! endochondral bone growth
created_by: dph
creation_date: 2009-12-22T08:57:42Z

[Term]
id: GO:0003418
name: growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:00:56Z

[Term]
id: GO:0003419
name: growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:02:51Z

[Term]
id: GO:0003420
name: regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061035 ! regulation of cartilage development
is_a: GO:2000027 ! regulation of organ morphogenesis
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation
relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation
created_by: dph
creation_date: 2009-12-22T09:07:40Z

[Term]
id: GO:0003421
name: growth plate cartilage axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T09:16:33Z

[Term]
id: GO:0003422
name: growth plate cartilage morphogenesis
namespace: biological_process
def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development
created_by: dph
creation_date: 2009-12-22T09:21:30Z

[Term]
id: GO:0003423
name: growth plate cartilage chondrocyte division
namespace: biological_process
def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation
created_by: dph
creation_date: 2009-12-22T09:55:51Z

[Term]
id: GO:0003424
name: establishment of cell polarity involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0030010 ! establishment of cell polarity
intersection_of: GO:0030010 ! establishment of cell polarity
intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division
relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T10:18:10Z

[Term]
id: GO:0003425
name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000132 ! establishment of mitotic spindle orientation
is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity
intersection_of: GO:0051294 ! establishment of spindle orientation
intersection_of: part_of GO:0003423 ! growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T10:36:36Z

[Term]
id: GO:0003426
name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
intersection_of: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division
relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T11:38:22Z

[Term]
id: GO:0003427
name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
is_a: GO:0051302 ! regulation of cell division
is_a: GO:0051493 ! regulation of cytoskeleton organization
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
is_a: GO:2000114 ! regulation of establishment of cell polarity
intersection_of: GO:0065007 ! biological regulation
intersection_of: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division
created_by: dph
creation_date: 2009-12-22T11:43:29Z

[Term]
id: GO:0003428
name: chondrocyte intercalation involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0060029 ! convergent extension involved in organogenesis
created_by: dph
creation_date: 2009-12-22T11:52:32Z

[Term]
id: GO:0003429
name: growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation
created_by: dph
creation_date: 2009-12-22T12:22:24Z

[Term]
id: GO:0003430
name: growth plate cartilage chondrocyte growth
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003415 ! chondrocyte hypertrophy
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T12:29:19Z

[Term]
id: GO:0003431
name: growth plate cartilage chondrocyte development
namespace: biological_process
def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation
created_by: dph
creation_date: 2009-12-22T12:32:49Z

[Term]
id: GO:0003432
name: cell growth involved in growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003430 ! growth plate cartilage chondrocyte growth
intersection_of: GO:0048588 ! developmental cell growth
intersection_of: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis
relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis
created_by: dph
creation_date: 2009-12-22T12:37:48Z

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
intersection_of: GO:0002063 ! chondrocyte development
intersection_of: part_of GO:0060350 ! endochondral bone morphogenesis
relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
created_by: dph
creation_date: 2009-12-22T12:42:44Z

[Term]
id: GO:0003434
name: BMP signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_a: GO:0030509 ! BMP signaling pathway
intersection_of: GO:0030509 ! BMP signaling pathway
intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T12:50:17Z

[Term]
id: GO:0003435
name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd]
synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah]
is_a: GO:0007224 ! smoothened signaling pathway
intersection_of: GO:0007224 ! smoothened signaling pathway
intersection_of: part_of GO:0003431 ! growth plate cartilage chondrocyte development
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development
created_by: dph
creation_date: 2009-12-22T01:02:42Z

[Term]
id: GO:0003436
name: regulation of cell adhesion involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
intersection_of: GO:0030155 ! regulation of cell adhesion
intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T01:28:15Z

[Term]
id: GO:0003437
name: regulation of cell communication involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
intersection_of: GO:0010646 ! regulation of cell communication
intersection_of: part_of GO:0003422 ! growth plate cartilage morphogenesis
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis
created_by: dph
creation_date: 2009-12-22T01:34:24Z

[Term]
id: GO:0003673
name: Gene_Ontology
namespace: biological_process
def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
is_obsolete: true

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_generic
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []
synonym: "molecular function unknown" NARROW []
disjoint_from: GO:0005575 ! cellular_component
disjoint_from: GO:0008150 ! biological_process

[Term]
id: GO:0003675
name: protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003678
name: DNA helicase activity
namespace: molecular_function
alt_id: GO:0003679
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_116013 "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA, Gallus gallus"
is_a: GO:0004386 ! helicase activity
relationship: part_of GO:0032508 ! DNA duplex unwinding

[Term]
id: GO:0003680
name: AT DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
synonym: "AT binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003681
name: bent DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]
subset: goslim_pir
subset: goslim_plant
synonym: "lamin/chromatin binding" BROAD []
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003683
name: lamin/chromatin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two functions.
is_obsolete: true
replaced_by: GO:0003682
replaced_by: GO:0005521

[Term]
id: GO:0003684
name: damaged DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
subset: gosubset_prok
synonym: "DNA repair enzyme" RELATED []
synonym: "DNA repair protein" RELATED []
xref: Reactome:REACT_100664 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_101048 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_101116 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_103019 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_103328 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_103380 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_103899 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_104175 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_104346 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_105157 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_105628 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_106525 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_110972 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_110979 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_113582 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_113713 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_113838 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_114851 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_1435 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_1696 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_1934 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_2185 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_28366 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_29673 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_30891 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_31436 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_33416 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_33600 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_33888 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_462 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Homo sapiens"
xref: Reactome:REACT_52866 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_77587 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Danio rerio"
xref: Reactome:REACT_783 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Homo sapiens"
xref: Reactome:REACT_79824 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_81071 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_81112 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_81735 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Sus scrofa"
xref: Reactome:REACT_82167 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_83944 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Bos taurus"
xref: Reactome:REACT_84763 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Gallus gallus"
xref: Reactome:REACT_84781 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_84951 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_85779 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Oryza sativa"
xref: Reactome:REACT_86067 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_87009 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Rattus norvegicus"
xref: Reactome:REACT_88774 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Canis familiaris"
xref: Reactome:REACT_88901 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_89666 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Xenopus tropicalis"
xref: Reactome:REACT_89685 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_89917 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_90545 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Canis familiaris"
xref: Reactome:REACT_91221 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Bos taurus"
xref: Reactome:REACT_91729 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Gallus gallus"
xref: Reactome:REACT_91817 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Taeniopygia guttata"
xref: Reactome:REACT_92004 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Danio rerio"
xref: Reactome:REACT_92429 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mus musculus"
xref: Reactome:REACT_93699 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_93716 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Gallus gallus"
xref: Reactome:REACT_93739 "Oxidative demethylation of 1-EtA damaged DNA By ABH2, Mycobacterium tuberculosis"
xref: Reactome:REACT_94142 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Xenopus tropicalis"
xref: Reactome:REACT_94682 "Oxidative demethylation of 1-EtA damaged DNA By ABH3, Mus musculus"
xref: Reactome:REACT_95130 "Oxidative demethylation of 1-MeA damaged DNA By ABH2, Arabidopsis thaliana"
xref: Reactome:REACT_97138 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_97358 "Oxidative demethylation of 3-MeC damaged DNA By ABH3, Rattus norvegicus"
xref: Reactome:REACT_98435 "Oxidative demethylation of 3-MeC damaged DNA By ABH2, Taeniopygia guttata"
xref: Reactome:REACT_98953 "Oxidative demethylation of 1-MeA damaged DNA By ABH3, Gallus gallus"
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003685
name: DNA repair protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003686
name: DNA repair enzyme
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003687
name: DNA replication factor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0003688
name: DNA replication origin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators]
subset: gosubset_prok
synonym: "ARS binding" NARROW []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003689
name: DNA clamp loader activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]
subset: gosubset_prok
synonym: "DNA clamp loading ATPase activity" EXACT []
synonym: "PCNA loading activity" NARROW []
synonym: "PCNA loading complex activity" NARROW []
xref: Reactome:REACT_106382 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster"
xref: Reactome:REACT_107423 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans"
xref: Reactome:REACT_113703 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus"
xref: Reactome:REACT_29764 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata"
xref: Reactome:REACT_33572 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum"
xref: Reactome:REACT_50018 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus"
xref: Reactome:REACT_6729 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens"
xref: Reactome:REACT_79188 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris"
xref: Reactome:REACT_88384 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_90809 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio"
xref: Reactome:REACT_92527 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus"
xref: Reactome:REACT_92644 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis"
xref: Reactome:REACT_96998 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus"
is_a: GO:0003677 ! DNA binding
is_a: GO:0033170 ! protein-DNA loading ATPase activity

[Term]
id: GO:0003690
name: double-stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
subset: gosubset_prok
synonym: "dsDNA binding" EXACT [GOC:elh]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003691
name: double-stranded telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0003692
name: left-handed Z-DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003693
name: P-element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003694
name: plasmid binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732]
comment: This term was made obsolete because it refers to component information.
synonym: "plasmid-associated protein" RELATED []
is_obsolete: true
consider: GO:0003677
consider: GO:0005727

[Term]
id: GO:0003695
name: random coil DNA binding
namespace: molecular_function
alt_id: GO:0016017
def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah]
synonym: "random coil binding" EXACT []
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003696
name: satellite DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003697
name: single-stranded DNA binding
namespace: molecular_function
alt_id: GO:0003698
alt_id: GO:0003699
def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh]
comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA.
subset: gosubset_prok
synonym: "ssDNA binding" EXACT [GOC:mah]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003700
name: sequence-specific DNA binding transcription factor activity
namespace: molecular_function
alt_id: GO:0000130
def: "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]
subset: goslim_plant
subset: gosubset_prok
synonym: "transcription factor activity" BROAD []
is_a: GO:0001071 ! nucleic acid binding transcription factor activity
relationship: has_part GO:0000976 ! transcription regulatory region sequence-specific DNA binding
relationship: part_of GO:0006355 ! regulation of transcription, DNA-dependent

[Term]
id: GO:0003701
name: RNA polymerase I transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
is_obsolete: true
consider: GO:0001082
consider: GO:0001167
consider: GO:0006360

[Term]
id: GO:0003702
name: RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0003704
name: specific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma]
comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
is_obsolete: true
consider: GO:0000981
consider: GO:0000991
consider: GO:0001076
consider: GO:0006366

[Term]
id: GO:0003705
name: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]
synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" EXACT []
is_a: GO:0000981 ! sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding

[Term]
id: GO:0003706
name: ligand-regulated transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators]
comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism.
is_obsolete: true
consider: GO:0004879
consider: GO:0038049

[Term]
id: GO:0003707
name: steroid hormone receptor activity
namespace: molecular_function
def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]
comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'.
is_a: GO:0038023 ! signaling receptor activity
relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway

[Term]
id: GO:0003708
name: retinoic acid receptor activity
namespace: molecular_function
def: "Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A." [GOC:signaling, PMID:1328967]
synonym: "vitamin A receptor activity" BROAD []
is_a: GO:0004879 ! ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
relationship: has_part GO:0001972 ! retinoic acid binding
relationship: part_of GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0003709
name: RNA polymerase III transcription factor activity
namespace: molecular_function
def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
is_obsolete: true
consider: GO:0000995
consider: GO:0001007
consider: GO:0001034
consider: GO:0006383

[Term]
id: GO:0003711
name: transcription elongation regulator activity
namespace: molecular_function
def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcription elongation factor activity" EXACT []
synonym: "transcriptional elongation regulator activity" EXACT []
is_obsolete: true
consider: GO:0032784

[Term]
id: GO:0003712
name: transcription cofactor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "transcriptional co-regulator" EXACT []
synonym: "transcriptional cofactor activity" EXACT []
is_a: GO:0000989 ! transcription factor binding transcription factor activity
relationship: has_part GO:0001098 ! basal transcription machinery binding

[Term]
id: GO:0003713
name: transcription coactivator activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
subset: gosubset_prok
synonym: "transcription co-activator activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0033613 ! activating transcription factor binding

[Term]
id: GO:0003714
name: transcription corepressor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]
synonym: "transcription co-repressor activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
relationship: has_part GO:0070491 ! repressing transcription factor binding

[Term]
id: GO:0003715
name: transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
subset: gosubset_prok
synonym: "transcriptional termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006353

[Term]
id: GO:0003716
name: RNA polymerase I transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol I transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006363

[Term]
id: GO:0003717
name: RNA polymerase II transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol II transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006369

[Term]
id: GO:0003718
name: RNA polymerase III transcription termination factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah]
comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function.
synonym: "Pol III transcription termination factor activity" EXACT []
is_obsolete: true
consider: GO:0006386

[Term]
id: GO:0003719
name: transcription factor binding, cytoplasmic sequestering
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process rather than a function.
is_obsolete: true
replaced_by: GO:0042994

[Term]
id: GO:0003720
name: telomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc]
xref: EC:2.7.7.-
xref: Reactome:REACT_104705 "Elongation of Extended Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_106476 "Elongation Of The Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_108407 "Elongation of Extended Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_109443 "Elongation Of The Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_113385 "Elongation Of The Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_114466 "Elongation of Extended Telomeric Chromosome End, Xenopus tropicalis"
xref: Reactome:REACT_115824 "Elongation and translocation of the extended telomeric chromosome end, Gallus gallus"
xref: Reactome:REACT_116122 "Elongation and translocation of the telomeric chromosome end, Gallus gallus"
xref: Reactome:REACT_28249 "Elongation of Extended Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_30494 "Elongation Of The Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_30995 "Elongation Of The Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_31549 "Elongation Of The Telomeric Chromosome End, Saccharomyces cerevisiae"
xref: Reactome:REACT_33436 "Elongation of Extended Telomeric Chromosome End, Danio rerio"
xref: Reactome:REACT_77280 "Elongation of Extended Telomeric Chromosome End, Arabidopsis thaliana"
xref: Reactome:REACT_7985 "Elongation of Extended Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_8019 "Elongation Of The Telomeric Chromosome End, Homo sapiens"
xref: Reactome:REACT_80834 "Elongation Of The Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_81691 "Elongation of Extended Telomeric Chromosome End, Canis familiaris"
xref: Reactome:REACT_83982 "Elongation Of The Telomeric Chromosome End, Oryza sativa"
xref: Reactome:REACT_85286 "Elongation of Extended Telomeric Chromosome End, Bos taurus"
xref: Reactome:REACT_86666 "Elongation of Extended Telomeric Chromosome End, Sus scrofa"
xref: Reactome:REACT_90823 "Elongation of Extended Telomeric Chromosome End, Mus musculus"
xref: Reactome:REACT_93232 "Elongation Of The Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_94534 "Elongation Of The Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_94768 "Elongation of Extended Telomeric Chromosome End, Schizosaccharomyces pombe"
xref: Reactome:REACT_95176 "Elongation Of The Telomeric Chromosome End, Gallus gallus"
xref: Reactome:REACT_96912 "Elongation of Extended Telomeric Chromosome End, Taeniopygia guttata"
xref: Reactome:REACT_97770 "Elongation Of The Telomeric Chromosome End, Arabidopsis thaliana"
is_a: GO:0003964 ! RNA-directed DNA polymerase activity

[Term]
id: GO:0003721
name: telomeric template RNA reverse transcriptase activity
namespace: molecular_function
def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242]
synonym: "telomerase, catalyst" EXACT []
is_a: GO:0003964 ! RNA-directed DNA polymerase activity
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis"
xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum"
xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus"
xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster"
xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa"
xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae"
xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana"
xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens"
xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris"
xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus"
xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa"
xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe"
xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus"
xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio"
xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003724
name: RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: EC:2.7.7.-
xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus"
xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe"
xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens"
xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio"
xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris"
xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster"
xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis"
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0003725
name: double-stranded RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
subset: gosubset_prok
synonym: "dsRNA binding" EXACT [GOC:ecd]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003726
name: double-stranded RNA adenosine deaminase activity
namespace: molecular_function
alt_id: GO:0003971
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "double-stranded RNA specific editase activity" RELATED []
xref: Reactome:REACT_100080 "Deamination at C6 position of adenosine in Editosome (ADAR2), Taeniopygia guttata"
xref: Reactome:REACT_104541 "Deamination at C6 position of adenosine in Editosome (ADAR1), Sus scrofa"
xref: Reactome:REACT_110356 "Deamination at C6 position of adenosine in Editosome (ADAR1), Xenopus tropicalis"
xref: Reactome:REACT_1105 "Deamination at C6 position of adenosine in Editosome (ADAR1), Homo sapiens"
xref: Reactome:REACT_112019 "Deamination at C6 position of adenosine in Editosome (ADAR1), Oryza sativa"
xref: Reactome:REACT_112024 "Deamination at C6 position of adenosine in Editosome (ADAR1), Saccharomyces cerevisiae"
xref: Reactome:REACT_113770 "Deamination at C6 position of adenosine in Editosome (ADAR1), Caenorhabditis elegans"
xref: Reactome:REACT_114900 "Deamination at C6 position of adenosine in Editosome (ADAR1), Arabidopsis thaliana"
xref: Reactome:REACT_115470 "Deamination at C6 position of adenosine in Editosome (ADAR1), Schizosaccharomyces pombe"
xref: Reactome:REACT_29892 "Deamination at C6 position of adenosine in Editosome (ADAR2), Canis familiaris"
xref: Reactome:REACT_31966 "Deamination at C6 position of adenosine in Editosome (ADAR1), Canis familiaris"
xref: Reactome:REACT_32015 "Deamination at C6 position of adenosine in Editosome (ADAR2), Xenopus tropicalis"
xref: Reactome:REACT_365 "Deamination at C6 position of adenosine in Editosome (ADAR2), Homo sapiens"
xref: Reactome:REACT_79183 "Deamination at C6 position of adenosine in Editosome (ADAR2), Mus musculus"
xref: Reactome:REACT_79641 "Deamination at C6 position of adenosine in Editosome (ADAR1), Taeniopygia guttata"
xref: Reactome:REACT_80597 "Deamination at C6 position of adenosine in Editosome (ADAR2), Gallus gallus"
xref: Reactome:REACT_80662 "Deamination at C6 position of adenosine in Editosome (ADAR2), Bos taurus"
xref: Reactome:REACT_86066 "Deamination at C6 position of adenosine in Editosome (ADAR2), Sus scrofa"
xref: Reactome:REACT_86370 "Deamination at C6 position of adenosine in Editosome (ADAR1), Gallus gallus"
xref: Reactome:REACT_86554 "Deamination at C6 position of adenosine in Editosome (ADAR1), Rattus norvegicus"
xref: Reactome:REACT_87527 "Deamination at C6 position of adenosine in Editosome (ADAR1), Mus musculus"
xref: Reactome:REACT_90605 "Deamination at C6 position of adenosine in Editosome (ADAR2), Rattus norvegicus"
xref: Reactome:REACT_90645 "Deamination at C6 position of adenosine in Editosome (ADAR2), Danio rerio"
xref: Reactome:REACT_92526 "Deamination at C6 position of adenosine in Editosome (ADAR2), Drosophila melanogaster"
xref: Reactome:REACT_99543 "Deamination at C6 position of adenosine in Editosome (ADAR1), Bos taurus"
xref: Reactome:REACT_99769 "Deamination at C6 position of adenosine in Editosome (ADAR1), Danio rerio"
is_a: GO:0004000 ! adenosine deaminase activity

[Term]
id: GO:0003727
name: single-stranded RNA binding
namespace: molecular_function
alt_id: GO:0003728
def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
synonym: "ssRNA binding" EXACT [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003729
name: mRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003730
name: mRNA 3'-UTR binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
synonym: "mRNA 3' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0003731
name: mRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003732
name: snRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003733
name: ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
is_obsolete: true
replaced_by: GO:0030529

[Term]
id: GO:0003734
name: small nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "snRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030532

[Term]
id: GO:0003735
name: structural constituent of ribosome
namespace: molecular_function
alt_id: GO:0003736
alt_id: GO:0003737
alt_id: GO:0003738
alt_id: GO:0003739
alt_id: GO:0003740
alt_id: GO:0003741
alt_id: GO:0003742
def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal protein" BROAD []
synonym: "ribosomal RNA" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0003743
name: translation initiation factor activity
namespace: molecular_function
alt_id: GO:0003744
alt_id: GO:0003745
def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_102411 "eIF2 activation, Arabidopsis thaliana"
xref: Reactome:REACT_102747 "Ribosomal scanning, Plasmodium falciparum"
xref: Reactome:REACT_104592 "Ribosomal scanning, Xenopus tropicalis"
xref: Reactome:REACT_104947 "Start codon recognition, Arabidopsis thaliana"
xref: Reactome:REACT_105336 "Ribosomal scanning, Danio rerio"
xref: Reactome:REACT_105545 "eIF2 activation, Schizosaccharomyces pombe"
xref: Reactome:REACT_105772 "Ribosomal scanning, Caenorhabditis elegans"
xref: Reactome:REACT_106049 "Ribosomal scanning, Schizosaccharomyces pombe"
xref: Reactome:REACT_107324 "eIF2 activation, Taeniopygia guttata"
xref: Reactome:REACT_108980 "Ribosomal scanning, Canis familiaris"
xref: Reactome:REACT_112013 "Start codon recognition, Gallus gallus"
xref: Reactome:REACT_114676 "Ribosomal scanning, Gallus gallus"
xref: Reactome:REACT_115071 "Ribosomal scanning, Rattus norvegicus"
xref: Reactome:REACT_115079 "Start codon recognition, Rattus norvegicus"
xref: Reactome:REACT_115451 "Start codon recognition, Bos taurus"
xref: Reactome:REACT_1401 "eIF2 activation, Homo sapiens"
xref: Reactome:REACT_1516 "Ribosomal scanning, Homo sapiens"
xref: Reactome:REACT_29285 "eIF2 activation, Danio rerio"
xref: Reactome:REACT_31248 "Ribosomal scanning, Drosophila melanogaster"
xref: Reactome:REACT_31637 "Start codon recognition, Saccharomyces cerevisiae"
xref: Reactome:REACT_32686 "eIF2 activation, Oryza sativa"
xref: Reactome:REACT_33398 "Start codon recognition, Oryza sativa"
xref: Reactome:REACT_33544 "Start codon recognition, Xenopus tropicalis"
xref: Reactome:REACT_57036 "Start codon recognition, Plasmodium falciparum"
xref: Reactome:REACT_60464 "eIF2 activation, Caenorhabditis elegans"
xref: Reactome:REACT_656 "Start codon recognition, Homo sapiens"
xref: Reactome:REACT_78159 "Start codon recognition, Caenorhabditis elegans"
xref: Reactome:REACT_78773 "eIF2 activation, Plasmodium falciparum"
xref: Reactome:REACT_79007 "Start codon recognition, Danio rerio"
xref: Reactome:REACT_81171 "Start codon recognition, Mus musculus"
xref: Reactome:REACT_82224 "eIF2 activation, Gallus gallus"
xref: Reactome:REACT_83059 "eIF2 activation, Bos taurus"
xref: Reactome:REACT_83547 "eIF2 activation, Rattus norvegicus"
xref: Reactome:REACT_83592 "eIF2 activation, Saccharomyces cerevisiae"
xref: Reactome:REACT_88632 "eIF2 activation, Mus musculus"
xref: Reactome:REACT_88913 "Ribosomal scanning, Bos taurus"
xref: Reactome:REACT_88955 "eIF2 activation, Xenopus tropicalis"
xref: Reactome:REACT_91084 "Ribosomal scanning, Arabidopsis thaliana"
xref: Reactome:REACT_91415 "Start codon recognition, Dictyostelium discoideum"
xref: Reactome:REACT_91967 "Ribosomal scanning, Dictyostelium discoideum"
xref: Reactome:REACT_91979 "Ribosomal scanning, Taeniopygia guttata"
xref: Reactome:REACT_93372 "Start codon recognition, Schizosaccharomyces pombe"
xref: Reactome:REACT_93678 "eIF2 activation, Canis familiaris"
xref: Reactome:REACT_95840 "Ribosomal scanning, Saccharomyces cerevisiae"
xref: Reactome:REACT_96533 "Ribosomal scanning, Oryza sativa"
xref: Reactome:REACT_96726 "eIF2 activation, Dictyostelium discoideum"
xref: Reactome:REACT_99607 "Ribosomal scanning, Mus musculus"
is_a: GO:0008135 ! translation factor activity, nucleic acid binding
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0003746
name: translation elongation factor activity
namespace: molecular_function
alt_id: GO:0008182
alt_id: GO:0008183
def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732]
subset: gosubset_prok
xref: Reactome:REACT_9514 "Viral Protein Synthesis, Homo sapiens"
xref: Reactome:REACT_9524 "Synthesis of PB1-F2, Homo sapiens"
is_a: GO:0008135 ! translation factor activity, nucleic acid binding
relationship: part_of GO:0006414 ! translational elongation

[Term]
id: GO:0003747
name: translation release factor activity
namespace: molecular_function
alt_id: GO:0003748
alt_id: GO:0003749
def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0008079 ! translation termination factor activity

[Term]
id: GO:0003750
name: cell cycle regulator
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a single molecular function.
is_obsolete: true
replaced_by: GO:0051726

[Term]
id: GO:0003754
name: chaperone activity
namespace: molecular_function
alt_id: GO:0003757
alt_id: GO:0003758
alt_id: GO:0003760
alt_id: GO:0003761
def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684]
comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003755
name: peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
alt_id: GO:0004752
alt_id: GO:0042028
def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
subset: gosubset_prok
synonym: "cis-trans proline isomerase activity" EXACT []
synonym: "cyclophilin activity" RELATED [EC:5.2.1.8]
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW []
synonym: "immunophilin" RELATED []
synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah]
synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah]
synonym: "parvulin" RELATED []
synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidyl-prolyl isomerase B reaction" RELATED []
synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8]
synonym: "PPIase activity" EXACT [EC:5.2.1.8]
synonym: "rotamase activity" EXACT [EC:5.2.1.8]
xref: EC:5.2.1.8
xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity
relationship: part_of GO:0000413 ! protein peptidyl-prolyl isomerization

[Term]
id: GO:0003756
name: protein disulfide isomerase activity
namespace: molecular_function
def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
subset: gosubset_prok
synonym: "protein cysteine-thiol oxidation" RELATED []
synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1]
synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1]
synonym: "protein disulphide isomerase activity" EXACT []
synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1]
xref: EC:5.3.4.1
xref: MetaCyc:5.3.4.1-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups
is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds

[Term]
id: GO:0003759
name: glycoprotein-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003762
name: histone-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "nucleosome assembly chaperone" EXACT []
is_obsolete: true
consider: GO:0006333
consider: GO:0006334
consider: GO:0034728
consider: GO:0042393
consider: GO:0043486
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003763
name: chaperonin ATPase activity
namespace: molecular_function
alt_id: GO:0003764
alt_id: GO:0003765
alt_id: GO:0003766
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "chaperonin" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006457

[Term]
id: GO:0003767
name: co-chaperone activity
namespace: molecular_function
alt_id: GO:0003768
alt_id: GO:0003769
alt_id: GO:0003770
alt_id: GO:0003771
def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003772
name: co-chaperonin activity
namespace: molecular_function
def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003773
name: heat shock protein activity
namespace: molecular_function
def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006986
consider: GO:0042026

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]
subset: goslim_aspergillus
subset: goslim_candida
subset: goslim_metagenomics
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0003775
name: axonemal motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
is_obsolete: true
consider: GO:0003777
consider: GO:0005930

[Term]
id: GO:0003776
name: muscle motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes anatomy information.
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0006936
consider: GO:0043292

[Term]
id: GO:0003777
name: microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.
synonym: "axonemal motor activity" NARROW []
synonym: "dynein" BROAD []
synonym: "dynein ATPase activity" NARROW []
synonym: "kinesin" BROAD []
synonym: "kinesin motor activity" NARROW []
synonym: "kinetochore motor activity" NARROW []
xref: Reactome:REACT_102513 "Axonal transport of NGF:Trk complexes, Danio rerio"
xref: Reactome:REACT_103791 "Translocation of Insulin Secretory Granules to Cell Cortex, Danio rerio"
xref: Reactome:REACT_105852 "Translocation of Insulin Secretory Granules to Cell Cortex, Bos taurus"
xref: Reactome:REACT_106252 "Translocation of Insulin Secretory Granules to Cell Cortex, Xenopus tropicalis"
xref: Reactome:REACT_113466 "Axonal transport of NGF:Trk complexes, Caenorhabditis elegans"
xref: Reactome:REACT_115371 "Translocation of Insulin Secretory Granules to Cell Cortex, Gallus gallus"
xref: Reactome:REACT_12385 "Axonal transport of NGF:Trk complexes, Homo sapiens"
xref: Reactome:REACT_15477 "Translocation of Insulin Secretory Granules to Cell Cortex, Homo sapiens"
xref: Reactome:REACT_20570 "Translocation of Insulin Secretory Granules to Cell Cortex, Mus musculus"
xref: Reactome:REACT_31982 "Axonal transport of NGF:Trk complexes, Sus scrofa"
xref: Reactome:REACT_32872 "Axonal transport of NGF:Trk complexes, Mus musculus"
xref: Reactome:REACT_33543 "Translocation of Insulin Secretory Granules to Cell Cortex, Rattus norvegicus"
xref: Reactome:REACT_77014 "Axonal transport of NGF:Trk complexes, Drosophila melanogaster"
xref: Reactome:REACT_78584 "Axonal transport of NGF:Trk complexes, Gallus gallus"
xref: Reactome:REACT_86678 "Translocation of Insulin Secretory Granules to Cell Cortex, Canis familiaris"
xref: Reactome:REACT_87390 "Axonal transport of NGF:Trk complexes, Bos taurus"
xref: Reactome:REACT_89365 "Axonal transport of NGF:Trk complexes, Taeniopygia guttata"
xref: Reactome:REACT_92428 "Translocation of Insulin Secretory Granules to Cell Cortex, Taeniopygia guttata"
xref: Reactome:REACT_94549 "Axonal transport of NGF:Trk complexes, Canis familiaris"
xref: Reactome:REACT_95164 "Axonal transport of NGF:Trk complexes, Xenopus tropicalis"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0003778
name: dynactin motor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.
is_obsolete: true

[Term]
id: GO:0003779
name: actin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
synonym: "membrane associated actin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0003780
name: actin cross-linking activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid]
comment: This term was made obsolete because it represents a combination of molecular functions.
is_obsolete: true
replaced_by: GO:0030674
replaced_by: GO:0051015

[Term]
id: GO:0003781
name: actin bundling activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0051017

[Term]
id: GO:0003782
name: F-actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003783
name: barbed-end actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003784
name: barbed-end actin capping/severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes two biological processes.
is_obsolete: true
replaced_by: GO:0051014
replaced_by: GO:0051016

[Term]
id: GO:0003785
name: actin monomer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai]
synonym: "G actin binding" EXACT []
is_a: GO:0003779 ! actin binding

[Term]
id: GO:0003786
name: actin lateral binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah]
is_a: GO:0051015 ! actin filament binding

[Term]
id: GO:0003787
name: actin depolymerizing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0030042

[Term]
id: GO:0003788
name: actin monomer sequestering activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process, not an activity.
is_obsolete: true
replaced_by: GO:0042989

[Term]
id: GO:0003789
name: actin filament severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051014

[Term]
id: GO:0003790
name: actin modulating activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not make sense.
is_obsolete: true
consider: GO:0030036

[Term]
id: GO:0003791
name: membrane associated actin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0003779
consider: GO:0016020

[Term]
id: GO:0003792
name: regulation of actin thin filament length activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the term belongs in the process ontology.
is_obsolete: true
replaced_by: GO:0030832

[Term]
id: GO:0003793
name: defense/immunity protein activity
namespace: molecular_function
def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "defence/immunity protein activity" EXACT []
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003794
name: acute-phase response protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0006953

[Term]
id: GO:0003795
name: antimicrobial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003796
name: lysozyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
subset: gosubset_prok
synonym: "1,4-N-acetylmuramidase activity" EXACT []
synonym: "globulin G" RELATED [EC:3.2.1.17]
synonym: "globulin G1" RELATED [EC:3.2.1.17]
synonym: "L-7001" RELATED [EC:3.2.1.17]
synonym: "lysozyme g" RELATED [EC:3.2.1.17]
synonym: "mucopeptide glucohydrolase activity" EXACT []
synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT []
synonym: "muramidase activity" EXACT []
synonym: "N,O-diacetylmuramidase activity" EXACT []
synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17]
synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17]
xref: EC:3.2.1.17
xref: MetaCyc:3.2.1.17-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003797
name: antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0042742

[Term]
id: GO:0003798
name: male-specific antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050831

[Term]
id: GO:0003799
name: antifungal peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050832

[Term]
id: GO:0003800
name: antiviral response protein activity
namespace: molecular_function
def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0009615

[Term]
id: GO:0003801
name: blood coagulation factor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0004252
consider: GO:0007596

[Term]
id: GO:0003802
name: coagulation factor VIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21]
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21]
xref: EC:3.4.21.21
xref: MetaCyc:3.4.21.21-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003803
name: coagulation factor IXa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22]
synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22]
synonym: "activated christmas factor" RELATED [EC:3.4.21.22]
synonym: "autoprothrombin II" RELATED [EC:3.4.21.22]
synonym: "blood coagulation factor IX activity" EXACT []
synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22]
synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22]
synonym: "Christmas factor activity" EXACT [EC:3.4.21.22]
xref: EC:3.4.21.22
xref: MetaCyc:3.4.21.22-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003804
name: coagulation factor Xa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6]
synonym: "activated factor X" RELATED [EC:3.4.21.6]
synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6]
synonym: "autoprothrombin C" RELATED [EC:3.4.21.6]
synonym: "blood coagulation factor X activity" EXACT []
synonym: "factor Xa" RELATED [EC:3.4.21.6]
synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6]
synonym: "prothrombase activity" EXACT [EC:3.4.21.6]
synonym: "prothrombinase activity" EXACT [EC:3.4.21.6]
synonym: "Stuart factor" RELATED [EC:3.4.21.6]
synonym: "Stuart factor activity" EXACT [EC:3.4.21.6]
synonym: "thrombokinase activity" EXACT [EC:3.4.21.6]
synonym: "thromboplastin" RELATED [EC:3.4.21.6]
xref: EC:3.4.21.6
xref: MetaCyc:3.4.21.6-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003805
name: coagulation factor XIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27]
synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27]
synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27]
synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27]
xref: EC:3.4.21.27
xref: MetaCyc:3.4.21.27-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003806
name: coagulation factor XIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38]
synonym: "blood coagulation factor XII activity" EXACT []
synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38]
synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38]
synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38]
synonym: "hageman factor activity" EXACT [EC:3.4.21.38]
synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38]
synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38]
synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38]
synonym: "prealbumin activator" RELATED [EC:3.4.21.38]
synonym: "prekallikrein activator" RELATED [EC:3.4.21.38]
xref: EC:3.4.21.38
xref: MetaCyc:3.4.21.38-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003807
name: plasma kallikrein activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD [EC:3.4.21.34]
synonym: "callicrein" RELATED [EC:3.4.21.34]
synonym: "depot-padutin" RELATED [EC:3.4.21.34]
synonym: "dilminal D" RELATED [EC:3.4.21.34]
synonym: "glumorin" RELATED [EC:3.4.21.34]
synonym: "kallidinogenase" BROAD [EC:3.4.21.34]
synonym: "kallikrein" RELATED [EC:3.4.21.34]
synonym: "kallikrein I" RELATED [EC:3.4.21.34]
synonym: "kallikrein II" RELATED [EC:3.4.21.34]
synonym: "kininogenase" BROAD [EC:3.4.21.34]
synonym: "kininogenin activity" RELATED [EC:3.4.21.34]
synonym: "onokrein P" RELATED [EC:3.4.21.34]
synonym: "padreatin" RELATED [EC:3.4.21.34]
synonym: "padutin" RELATED [EC:3.4.21.34]
synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34]
synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.34]
synonym: "urokallikrein" RELATED [EC:3.4.21.34]
xref: EC:3.4.21.34
xref: MetaCyc:3.4.21.34-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003808
name: protein C (activated) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69]
synonym: "activated protein C" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69]
synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69]
synonym: "GSAPC" RELATED [EC:3.4.21.69]
synonym: "protein Ca" RELATED [EC:3.4.21.69]
xref: EC:3.4.21.69
xref: MetaCyc:3.4.21.69-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003809
name: thrombin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5]
synonym: "beta-thrombin" RELATED [EC:3.4.21.5]
synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5]
synonym: "E thrombin" RELATED [EC:3.4.21.5]
synonym: "factor IIa" RELATED [EC:3.4.21.5]
synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5]
synonym: "gamma-thrombin" RELATED [EC:3.4.21.5]
synonym: "thrombase activity" EXACT [EC:3.4.21.5]
synonym: "thrombin-C" RELATED [EC:3.4.21.5]
synonym: "thrombofort" RELATED [EC:3.4.21.5]
synonym: "topical" RELATED [EC:3.4.21.5]
synonym: "tropostasin" RELATED [EC:3.4.21.5]
xref: EC:3.4.21.5
xref: MetaCyc:3.4.21.5-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
subset: gosubset_prok
synonym: "factor XIIIa" RELATED [EC:2.3.2.13]
synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13]
synonym: "fibrinoligase activity" EXACT []
synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13]
synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13]
synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13]
synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13]
synonym: "TGase activity" EXACT []
synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13]
synonym: "transglutaminase activity" EXACT []
xref: EC:2.3.2.13
xref: MetaCyc:2.3.2.13-RXN
xref: Reactome:REACT_101525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Canis familiaris"
xref: Reactome:REACT_112106 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Drosophila melanogaster"
xref: Reactome:REACT_112367 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Sus scrofa"
xref: Reactome:REACT_112902 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Xenopus tropicalis"
xref: Reactome:REACT_1852 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Homo sapiens"
xref: Reactome:REACT_37344 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Gallus gallus"
xref: Reactome:REACT_82525 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Bos taurus"
xref: Reactome:REACT_82887 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Rattus norvegicus"
xref: Reactome:REACT_89774 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Danio rerio"
xref: Reactome:REACT_97354 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Taeniopygia guttata"
xref: Reactome:REACT_98243 "fibrin multimer -> fibrin multimer, crosslinked + NH4+, Mus musculus"
xref: RESID:AA0124
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003811
name: complement activity
namespace: molecular_function
def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0003812
name: alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47]
synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47]
synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47]
synonym: "C3 convertase activity" BROAD [EC:3.4.21.47]
synonym: "C3 proactivator" RELATED [EC:3.4.21.47]
synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.47]
synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47]
synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47]
synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47]
synonym: "complement factor B activity" EXACT [EC:3.4.21.47]
synonym: "CVF,Bb" RELATED [EC:3.4.21.47]
synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47]
synonym: "heat-labile factor" RELATED [EC:3.4.21.47]
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" EXACT [EC:3.4.21.47]
xref: EC:3.4.21.47
xref: MetaCyc:3.4.21.47-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003813
name: classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3 convertase activity" BROAD [EC:3.4.21.43]
synonym: "C42" RELATED [EC:3.4.21.43]
synonym: "C423" RELATED [EC:3.4.21.43]
synonym: "C4b,2a" RELATED [EC:3.4.21.43]
synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.43]
synonym: "complement C2 activity" BROAD [EC:3.4.21.43]
synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43]
synonym: "complement C42" RELATED [EC:3.4.21.43]
xref: EC:3.4.21.43
xref: MetaCyc:3.4.21.43-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003815
name: complement component C1r activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1r" RELATED [EC:3.4.21.41]
synonym: "C1r esterase activity" EXACT [EC:3.4.21.41]
synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41]
xref: EC:3.4.21.41
xref: MetaCyc:3.4.21.41-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003816
name: complement component C1s activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1s" RELATED [EC:3.4.21.42]
synonym: "C1 esterase activity" EXACT [EC:3.4.21.42]
synonym: "C1s esterase activity" EXACT [EC:3.4.21.42]
synonym: "complement C1s" RELATED [EC:3.4.21.42]
synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42]
xref: EC:3.4.21.42
xref: MetaCyc:3.4.21.42-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003817
name: complement factor D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46]
comment: This term was made obsolete because it represents a gene product.
synonym: "adipsin" EXACT []
synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46]
synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46]
synonym: "factor D" RELATED [EC:3.4.21.46]
synonym: "factor D (complement)" RELATED [EC:3.4.21.46]
synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46]
xref: EC:3.4.21.46
xref: MetaCyc:3.4.21.46-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003818
name: complement factor I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45]
synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "C3bINA" RELATED [EC:3.4.21.45]
synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4bi" RELATED [EC:3.4.21.45]
synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45]
synonym: "factor I" RELATED [EC:3.4.21.45]
xref: EC:3.4.21.45
xref: MetaCyc:3.4.21.45-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003819
name: major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "MHC protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003820
name: class I major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true
consider: GO:0042612

[Term]
id: GO:0003821
name: class II major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true
consider: GO:0042613

[Term]
id: GO:0003822
name: MHC-interacting protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0003823
name: antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544]
subset: goslim_pir
synonym: "antibody" RELATED []
synonym: "B cell receptor activity" RELATED []
synonym: "immunoglobulin" RELATED []
synonym: "opsonin activity" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function
relationship: part_of GO:0008152 ! metabolic process

[Term]
id: GO:0003825
name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15]
synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15]
synonym: "transglucosylase activity" EXACT []
synonym: "trehalose 6-phosphate synthase activity" EXACT []
synonym: "trehalose 6-phosphate synthetase activity" EXACT []
synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-phosphate synthase activity" EXACT []
synonym: "trehalose-phosphate synthetase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT []
synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
xref: EC:2.4.1.15
xref: MetaCyc:TREHALOSE6PSYN-RXN
xref: Reactome:REACT_27138 "Glucose is transferred from UDP-glucose onto glucose-6-phosphate, Mycobacterium tuberculosis"
xref: RHEA:18892
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003826
name: alpha-ketoacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah]
subset: gosubset_prok
xref: Reactome:REACT_101696 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_101855 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Plasmodium falciparum"
xref: Reactome:REACT_102398 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_109062 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Canis familiaris"
xref: Reactome:REACT_113399 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_1813 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Homo sapiens"
xref: Reactome:REACT_30155 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Oryza sativa"
xref: Reactome:REACT_30632 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Gallus gallus"
xref: Reactome:REACT_30883 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_33771 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_34024 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Bos taurus"
xref: Reactome:REACT_34280 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_81262 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_86541 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Sus scrofa"
xref: Reactome:REACT_88849 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Mus musculus"
xref: Reactome:REACT_92556 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Danio rerio"
xref: Reactome:REACT_95085 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_96212 "a-ketoisocaproate, a-keto b-methylvalerate, or a-ketoisovalerate + CoA + NAD+ => isovaleryl-CoA, a-methylbutyryl-CoA, or isobuyryl-CoA + CO2 + NADH + H+, Dictyostelium discoideum"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0003827
name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459]
synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTI" RELATED [EC:2.4.1.101]
synonym: "GNTI activity" EXACT [EC:2.4.1.101]
synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
xref: EC:2.4.1.101
xref: KEGG:R05983
xref: MetaCyc:2.4.1.101-RXN
xref: Reactome:REACT_25236 "Addition of GlcNAc to the glycan on the A arm, Homo sapiens"
xref: RHEA:11459
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003828
name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8]
synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" EXACT [EC:2.4.99.8]
synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" EXACT [EC:2.4.99.8]
synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8]
synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "SAT-2" RELATED [EC:2.4.99.8]
xref: EC:2.4.99.8
xref: MetaCyc:2.4.99.8-RXN
xref: Reactome:REACT_103372 "Polysialylation of NCAM1, Canis familiaris"
xref: Reactome:REACT_103428 "Polysialylation of NCAM1, Taeniopygia guttata"
xref: Reactome:REACT_104790 "Polysialylation of NCAM1, Sus scrofa"
xref: Reactome:REACT_105388 "Polysialylation of NCAM1, Rattus norvegicus"
xref: Reactome:REACT_110734 "Polysialylation of NCAM1, Xenopus tropicalis"
xref: Reactome:REACT_18324 "Polysialylation of NCAM1, Homo sapiens"
xref: Reactome:REACT_25115 "Addition of alpha-2,8-sialic acid to N-glycan over a galactose by ST8SIAs, Homo sapiens"
xref: Reactome:REACT_32138 "Polysialylation of NCAM1, Danio rerio"
xref: Reactome:REACT_34632 "Polysialylation of NCAM1, Gallus gallus"
xref: Reactome:REACT_85065 "Polysialylation of NCAM1, Bos taurus"
xref: Reactome:REACT_86310 "Polysialylation of NCAM1, Mus musculus"
xref: RHEA:19316
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003829
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102]
synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
xref: EC:2.4.1.102
xref: MetaCyc:2.4.1.102-RXN
xref: Reactome:REACT_115554 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein, Homo sapiens"
xref: Reactome:REACT_115905 "Addition of GlcNAc to the T antigen forms a Core 2 glycoprotein, Homo sapiens"
xref: RHEA:18708
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003830
name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
subset: gosubset_prok
synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "GnTIII activity" EXACT [EC:2.4.1.144]
synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144]
xref: EC:2.4.1.144
xref: MetaCyc:2.4.1.144-RXN
xref: Reactome:REACT_25005 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3, Homo sapiens"
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003831
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "GalT activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38]
synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38]
synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
xref: EC:2.4.1.38
xref: MetaCyc:2.4.1.38-RXN
xref: Reactome:REACT_25178 "Addition of galactose by beta 4-galactosyltransferases, Homo sapiens"
xref: RHEA:22935
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003832
name: beta-alanyl-dopamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543]
synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT []
synonym: "NBAD hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003833
name: beta-alanyl-dopamine synthase activity
namespace: molecular_function
def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543]
synonym: "N-beta-alanyl dopamine synthetase activity" EXACT []
synonym: "NBAD transferase activity" EXACT []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0003834
name: beta-carotene 15,15'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407]
comment: Note that this function was formerly EC:1.13.11.21.
synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT []
synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36]
synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36]
synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36]
xref: EC:1.14.99.36
xref: KEGG:R00032
xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN
xref: Reactome:REACT_25117 "Oxidation of beta-carotene to retinal, Homo sapiens"
xref: RHEA:10407
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003835
name: beta-galactoside alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1]
synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1]
synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1]
xref: EC:2.4.99.1
xref: MetaCyc:2.4.99.1-RXN
xref: Reactome:REACT_115891 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position, Homo sapiens"
xref: Reactome:REACT_115991 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position, Homo sapiens"
xref: Reactome:REACT_24990 "Addition of alpha-2,6-sialic acid to terminal galactose of N-glycans by ST6GAL1, Homo sapiens"
xref: RHEA:11839
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003836
name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4]
xref: EC:2.4.99.4
xref: MetaCyc:2.4.99.4-RXN
xref: Reactome:REACT_116038 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position, Homo sapiens"
xref: Reactome:REACT_25121 "Addition of alpha-2,3-sialic acid to N-glycan over a galactose by ST3GAL4, Homo sapiens"
xref: RHEA:21619
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003837
name: beta-ureidopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
subset: gosubset_prok
synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6]
xref: EC:3.5.1.6
xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN
xref: Reactome:REACT_101423 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Xenopus tropicalis"
xref: Reactome:REACT_102071 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Danio rerio"
xref: Reactome:REACT_102892 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Canis familiaris"
xref: Reactome:REACT_103635 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Taeniopygia guttata"
xref: Reactome:REACT_103759 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Danio rerio"
xref: Reactome:REACT_104624 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Drosophila melanogaster"
xref: Reactome:REACT_104670 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Taeniopygia guttata"
xref: Reactome:REACT_105623 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Gallus gallus"
xref: Reactome:REACT_108466 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_110755 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_112730 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_115012 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Schizosaccharomyces pombe"
xref: Reactome:REACT_2183 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Homo sapiens"
xref: Reactome:REACT_28778 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Arabidopsis thaliana"
xref: Reactome:REACT_29340 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Oryza sativa"
xref: Reactome:REACT_34440 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Gallus gallus"
xref: Reactome:REACT_79448 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Xenopus tropicalis"
xref: Reactome:REACT_82451 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Sus scrofa"
xref: Reactome:REACT_84087 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Canis familiaris"
xref: Reactome:REACT_84098 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Mus musculus"
xref: Reactome:REACT_84968 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Bos taurus"
xref: Reactome:REACT_87205 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Drosophila melanogaster"
xref: Reactome:REACT_87574 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Sus scrofa"
xref: Reactome:REACT_87832 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Rattus norvegicus"
xref: Reactome:REACT_902 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Homo sapiens"
xref: Reactome:REACT_90983 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Caenorhabditis elegans"
xref: Reactome:REACT_92584 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Dictyostelium discoideum"
xref: Reactome:REACT_96079 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Bos taurus"
xref: Reactome:REACT_96886 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Mus musculus"
xref: Reactome:REACT_98071 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2, Oryza sativa"
xref: Reactome:REACT_99446 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Rattus norvegicus"
xref: Reactome:REACT_99655 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2, Caenorhabditis elegans"
xref: RHEA:11187
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003838
name: sterol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41]
subset: gosubset_prok
synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-sterol C-methyltransferase activity" EXACT []
synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "SMT1 activity" NARROW [EC:2.1.1.41]
synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41]
xref: EC:2.1.1.41
xref: MetaCyc:RXN3O-178
xref: RHEA:21131
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0003839
name: gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]
synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4]
synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4]
xref: EC:2.3.2.4
xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
xref: Reactome:REACT_75867 "5-oxoproline can be formed from gamma-glutamyl-AA products, Homo sapiens"
xref: Reactome:REACT_75929 "Formation of 5-oxoproline from gamma-glutamylcysteine, Homo sapiens"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003840
name: gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
subset: gosubset_prok
synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-GPT" RELATED [EC:2.3.2.2]
synonym: "gamma-GT" RELATED [EC:2.3.2.2]
synonym: "gamma-GTP" RELATED [EC:2.3.2.2]
synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2]
xref: EC:2.3.2.2
xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN
xref: Reactome:REACT_105103 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Taeniopygia guttata"
xref: Reactome:REACT_107509 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Xenopus tropicalis"
xref: Reactome:REACT_108503 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Escherichia coli"
xref: Reactome:REACT_109920 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Oryza sativa"
xref: Reactome:REACT_114722 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Caenorhabditis elegans"
xref: Reactome:REACT_15356 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Homo sapiens"
xref: Reactome:REACT_28900 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Saccharomyces cerevisiae"
xref: Reactome:REACT_29202 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Bos taurus"
xref: Reactome:REACT_75920 "Glutathione is hydrolyzed, Homo sapiens"
xref: Reactome:REACT_79594 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Danio rerio"
xref: Reactome:REACT_80649 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Sus scrofa"
xref: Reactome:REACT_82062 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Arabidopsis thaliana"
xref: Reactome:REACT_85164 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Schizosaccharomyces pombe"
xref: Reactome:REACT_92059 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Canis familiaris"
xref: Reactome:REACT_97168 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Mus musculus"
xref: Reactome:REACT_99498 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Gallus gallus"
xref: RHEA:28810
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003841
name: 1-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0004469
def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51]
subset: gosubset_prok
synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "lysophosphatidate acyltransferase activity" EXACT []
synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51]
xref: EC:2.3.1.51
xref: MetaCyc:RXN-1623
xref: Reactome:REACT_100569 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Drosophila melanogaster"
xref: Reactome:REACT_101159 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Bos taurus"
xref: Reactome:REACT_104719 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Oryza sativa"
xref: Reactome:REACT_108799 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Canis familiaris"
xref: Reactome:REACT_109082 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Xenopus tropicalis"
xref: Reactome:REACT_113184 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Dictyostelium discoideum"
xref: Reactome:REACT_113260 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Arabidopsis thaliana"
xref: Reactome:REACT_115377 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Caenorhabditis elegans"
xref: Reactome:REACT_2042 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Homo sapiens"
xref: Reactome:REACT_30683 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Gallus gallus"
xref: Reactome:REACT_32891 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Sus scrofa"
xref: Reactome:REACT_79417 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Danio rerio"
xref: Reactome:REACT_81957 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mus musculus"
xref: Reactome:REACT_84904 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Taeniopygia guttata"
xref: Reactome:REACT_93954 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Rattus norvegicus"
xref: Reactome:REACT_93992 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Escherichia coli"
xref: Reactome:REACT_96723 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Schizosaccharomyces pombe"
xref: Reactome:REACT_97949 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Saccharomyces cerevisiae"
xref: Reactome:REACT_99430 "1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH, Mycobacterium tuberculosis"
xref: RHEA:19712
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003842
name: 1-pyrroline-5-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12]
subset: gosubset_prok
synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12]
synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12]
xref: EC:1.5.1.12
xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN
xref: Reactome:REACT_101154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Gallus gallus"
xref: Reactome:REACT_2180 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Homo sapiens"
xref: Reactome:REACT_28267 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Bos taurus"
xref: Reactome:REACT_29350 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_30746 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_32976 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mus musculus"
xref: Reactome:REACT_33427 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_77246 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_78368 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Staphylococcus aureus N315"
xref: Reactome:REACT_79652 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_82290 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_83335 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Escherichia coli"
xref: Reactome:REACT_84624 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_88645 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Danio rerio"
xref: Reactome:REACT_91287 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_94154 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Canis familiaris"
xref: Reactome:REACT_97859 "L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+, Schizosaccharomyces pombe"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003843
name: 1,3-beta-D-glucan synthase activity
namespace: molecular_function
alt_id: GO:0009981
def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34]
synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "beta-1,3-glucan synthase activity" EXACT []
synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "callose synthase activity" EXACT []
synonym: "callose synthetase activity" EXACT [EC:2.4.1.34]
synonym: "GS-II" RELATED [EC:2.4.1.34]
synonym: "paramylon synthetase" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
xref: EC:2.4.1.34
xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003844
name: 1,4-alpha-glucan branching enzyme activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT []
synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT []
synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18]
synonym: "branching enzyme activity" RELATED [EC:2.4.1.18]
synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18]
synonym: "enzyme Q" RELATED [EC:2.4.1.18]
synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18]
synonym: "plant branching enzyme" RELATED [EC:2.4.1.18]
synonym: "Q-enzyme" RELATED [EC:2.4.1.18]
synonym: "starch branching enzyme" RELATED [EC:2.4.1.18]
xref: EC:2.4.1.18
xref: MetaCyc:GLYCOGEN-BRANCH-RXN
xref: Reactome:REACT_105148 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Danio rerio"
xref: Reactome:REACT_106694 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Caenorhabditis elegans"
xref: Reactome:REACT_107726 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Saccharomyces cerevisiae"
xref: Reactome:REACT_115406 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Arabidopsis thaliana"
xref: Reactome:REACT_1560 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Homo sapiens"
xref: Reactome:REACT_30904 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Bos taurus"
xref: Reactome:REACT_32069 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Taeniopygia guttata"
xref: Reactome:REACT_34100 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Canis familiaris"
xref: Reactome:REACT_86636 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Xenopus tropicalis"
xref: Reactome:REACT_89477 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Mus musculus"
xref: Reactome:REACT_89641 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Gallus gallus"
xref: Reactome:REACT_94260 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Rattus norvegicus"
xref: Reactome:REACT_94674 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Oryza sativa"
xref: Reactome:REACT_96621 "poly((1,4)-alpha-D-glucosyl) glycogenin => glycogen-glycogenin, Sus scrofa"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036]
subset: gosubset_prok
synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146]
synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146]
synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146]
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: Reactome:REACT_10043 "Oxidation of cortisol to yield cortisone, Homo sapiens"
xref: Reactome:REACT_102267 "Oxidation of cortisol to yield cortisone, Canis familiaris"
xref: Reactome:REACT_114165 "Oxidation of cortisol to yield cortisone, Plasmodium falciparum"
xref: Reactome:REACT_31438 "Oxidation of cortisol to yield cortisone, Mus musculus"
xref: Reactome:REACT_32859 "Oxidation of cortisol to yield cortisone, Dictyostelium discoideum"
xref: Reactome:REACT_82916 "Oxidation of cortisol to yield cortisone, Oryza sativa"
xref: Reactome:REACT_84167 "Oxidation of cortisol to yield cortisone, Xenopus tropicalis"
xref: Reactome:REACT_84288 "Oxidation of cortisol to yield cortisone, Sus scrofa"
xref: Reactome:REACT_86323 "Oxidation of cortisol to yield cortisone, Bos taurus"
xref: Reactome:REACT_86610 "Oxidation of cortisol to yield cortisone, Arabidopsis thaliana"
xref: Reactome:REACT_93487 "Oxidation of cortisol to yield cortisone, Gallus gallus"
xref: Reactome:REACT_95677 "Oxidation of cortisol to yield cortisone, Taeniopygia guttata"
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003846
name: 2-acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22]
synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
xref: EC:2.3.1.22
xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: RHEA:16744
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003847
name: 1-alkyl-2-acetylglycerophosphocholine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
subset: gosubset_prok
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT []
synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA2" RELATED [EC:3.1.1.47]
synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47]
xref: EC:3.1.1.47
xref: MetaCyc:3.1.1.47-RXN
is_a: GO:0052689 ! carboxylic ester hydrolase activity

[Term]
id: GO:0003848
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415]
subset: gosubset_prok
synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT []
synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3]
synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "HPPK" RELATED [EC:2.7.6.3]
synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3]
xref: EC:2.7.6.3
xref: KEGG:R03503
xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
xref: RHEA:11415
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0003849
name: 3-deoxy-7-phosphoheptulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720]
comment: Note that this function was formerly EC:4.1.2.15.
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54]
synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54]
synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54]
synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54]
synonym: "DS-Co activity" RELATED [EC:2.5.1.54]
synonym: "DS-Mn activity" RELATED [EC:2.5.1.54]
synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54]
synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54]
xref: EC:2.5.1.54
xref: KEGG:R01826
xref: MetaCyc:DAHPSYN-RXN
xref: Reactome:REACT_27267 "DHAP from Ery4P and PEP, Mycobacterium tuberculosis"
xref: RHEA:14720
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003850
name: 2-deoxyglucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68]
synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68]
synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68]
xref: EC:3.1.3.68
xref: KEGG:R02587
xref: MetaCyc:3.1.3.68-RXN
xref: RHEA:22239
is_a: GO:0050308 ! sugar-phosphatase activity

[Term]
id: GO:0003851
name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
xref: EC:2.4.1.45
xref: MetaCyc:2.4.1.45-RXN
xref: RHEA:10859
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003852
name: 2-isopropylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21527]
comment: Note that this function was formerly EC:4.1.3.12.
subset: gosubset_prok
synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13]
synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13]
synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
xref: EC:2.3.3.13
xref: KEGG:R01213
xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN
xref: RHEA:21527
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003853
name: 2-methylacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12]
synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12]
xref: EC:1.3.99.12
xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN
xref: RHEA:13264
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0003854
name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]
subset: gosubset_prok
synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT []
synonym: "3beta-HSDH" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145]
synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145]
xref: EC:1.1.1.145
xref: MetaCyc:1.1.1.145-RXN
xref: Reactome:REACT_10031 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Homo sapiens"
xref: Reactome:REACT_10067 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Homo sapiens"
xref: Reactome:REACT_100839 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Danio rerio"
xref: Reactome:REACT_10090 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Homo sapiens"
xref: Reactome:REACT_10115 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Homo sapiens"
xref: Reactome:REACT_101983 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Bos taurus"
xref: Reactome:REACT_103390 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Bos taurus"
xref: Reactome:REACT_103657 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Sus scrofa"
xref: Reactome:REACT_103990 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Danio rerio"
xref: Reactome:REACT_104422 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Drosophila melanogaster"
xref: Reactome:REACT_104615 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Gallus gallus"
xref: Reactome:REACT_105565 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mus musculus"
xref: Reactome:REACT_106120 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Bos taurus"
xref: Reactome:REACT_106214 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Danio rerio"
xref: Reactome:REACT_106644 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_108035 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Canis familiaris"
xref: Reactome:REACT_108087 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_108432 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Xenopus tropicalis"
xref: Reactome:REACT_109510 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mus musculus"
xref: Reactome:REACT_111989 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mycobacterium tuberculosis"
xref: Reactome:REACT_112248 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Escherichia coli"
xref: Reactome:REACT_113096 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mycobacterium tuberculosis"
xref: Reactome:REACT_113257 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Escherichia coli"
xref: Reactome:REACT_113772 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Escherichia coli"
xref: Reactome:REACT_114424 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Escherichia coli"
xref: Reactome:REACT_114777 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_114921 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_115275 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Escherichia coli"
xref: Reactome:REACT_115303 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mycobacterium tuberculosis"
xref: Reactome:REACT_28427 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Danio rerio"
xref: Reactome:REACT_28467 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_29450 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Danio rerio"
xref: Reactome:REACT_30525 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_30795 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Rattus norvegicus"
xref: Reactome:REACT_30899 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Canis familiaris"
xref: Reactome:REACT_32283 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Gallus gallus"
xref: Reactome:REACT_32783 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mus musculus"
xref: Reactome:REACT_32924 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Gallus gallus"
xref: Reactome:REACT_33199 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Sus scrofa"
xref: Reactome:REACT_33352 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Gallus gallus"
xref: Reactome:REACT_34556 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_77900 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_78893 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_79104 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Sus scrofa"
xref: Reactome:REACT_79525 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Rattus norvegicus"
xref: Reactome:REACT_79553 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Bos taurus"
xref: Reactome:REACT_80359 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Drosophila melanogaster"
xref: Reactome:REACT_80746 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Rattus norvegicus"
xref: Reactome:REACT_81646 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Taeniopygia guttata"
xref: Reactome:REACT_82293 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Sus scrofa"
xref: Reactome:REACT_82688 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mus musculus"
xref: Reactome:REACT_84251 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Canis familiaris"
xref: Reactome:REACT_85738 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Canis familiaris"
xref: Reactome:REACT_86717 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Drosophila melanogaster"
xref: Reactome:REACT_87612 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Taeniopygia guttata"
xref: Reactome:REACT_88118 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mus musculus"
xref: Reactome:REACT_88292 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Rattus norvegicus"
xref: Reactome:REACT_88643 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Xenopus tropicalis"
xref: Reactome:REACT_91120 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Gallus gallus"
xref: Reactome:REACT_93787 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Taeniopygia guttata"
xref: Reactome:REACT_94450 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Xenopus tropicalis"
xref: Reactome:REACT_96507 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Sus scrofa"
xref: Reactome:REACT_99573 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Canis familiaris"
xref: Reactome:REACT_99689 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Bos taurus"
xref: Reactome:REACT_9989 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Homo sapiens"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003855
name: 3-dehydroquinate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21099]
subset: gosubset_prok
synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "DHQase" EXACT [EC:4.2.1.10]
xref: EC:4.2.1.10
xref: KEGG:R03084
xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN
xref: Reactome:REACT_27221 "Dehydratation of DHQ yields DHS, Mycobacterium tuberculosis"
xref: RHEA:21099
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003856
name: 3-dehydroquinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971]
subset: gosubset_prok
synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4]
synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
synonym: "DHQ synthase" EXACT [PMID:17586643]
synonym: "DHQS" EXACT [PMID:17586643]
xref: EC:4.2.3.4
xref: KEGG:R03083
xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN
xref: Reactome:REACT_27251 "DHQ from DAHP dephosphorylation, Mycobacterium tuberculosis"
xref: RHEA:21971
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003857
name: 3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35]
comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
subset: gosubset_prok
synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079]
synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35]
synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
xref: EC:1.1.1.35
xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN
xref: Reactome:REACT_100238 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_100408 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_100617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_10065 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Homo sapiens"
xref: Reactome:REACT_101468 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_101506 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis"
xref: Reactome:REACT_101519 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_101647 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_101913 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Gallus gallus"
xref: Reactome:REACT_101921 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_102671 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_102910 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_102920 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_103002 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_103054 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_103256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_103362 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_103856 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_104004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_104064 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_104792 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_105101 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_105286 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_105300 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Sus scrofa"
xref: Reactome:REACT_106598 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Caenorhabditis elegans"
xref: Reactome:REACT_106630 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Caenorhabditis elegans"
xref: Reactome:REACT_106706 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_106767 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Canis familiaris"
xref: Reactome:REACT_106920 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_106947 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_106969 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_106993 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Drosophila melanogaster"
xref: Reactome:REACT_107615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Danio rerio"
xref: Reactome:REACT_107618 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_107700 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_107858 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_107953 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_107981 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_108093 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_108518 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_108521 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_109194 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_109636 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_109679 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus"
xref: Reactome:REACT_109823 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_109984 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_110388 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_110947 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_112490 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_113301 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_113705 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_115146 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_115227 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Staphylococcus aureus N315"
xref: Reactome:REACT_16971 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_16976 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_1908 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_21320 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+, Homo sapiens"
xref: Reactome:REACT_2187 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_2195 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_2238 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Homo sapiens"
xref: Reactome:REACT_242 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_28171 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Arabidopsis thaliana"
xref: Reactome:REACT_28279 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_28310 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_28475 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_28502 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_28542 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_28734 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_28832 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_28849 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_29078 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_29670 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_29976 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Mus musculus"
xref: Reactome:REACT_29995 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Oryza sativa"
xref: Reactome:REACT_29997 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_30800 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_30941 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_31004 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_31541 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Danio rerio"
xref: Reactome:REACT_31820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_31990 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Sus scrofa"
xref: Reactome:REACT_32500 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_32695 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Danio rerio"
xref: Reactome:REACT_32848 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Rattus norvegicus"
xref: Reactome:REACT_33031 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Sus scrofa"
xref: Reactome:REACT_33370 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster"
xref: Reactome:REACT_33795 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_33854 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_34140 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mycobacterium tuberculosis"
xref: Reactome:REACT_343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_34604 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Oryza sativa"
xref: Reactome:REACT_34731 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Escherichia coli"
xref: Reactome:REACT_440 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Homo sapiens"
xref: Reactome:REACT_447 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_457 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Homo sapiens"
xref: Reactome:REACT_488 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Homo sapiens"
xref: Reactome:REACT_76935 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_77072 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_77100 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_77507 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_77574 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_78964 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_78989 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_79125 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_79280 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_79436 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_79907 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_79918 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_80029 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_80406 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_80423 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_80706 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Rattus norvegicus"
xref: Reactome:REACT_80985 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_81132 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_81339 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_81483 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mus musculus"
xref: Reactome:REACT_81715 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_81942 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Drosophila melanogaster"
xref: Reactome:REACT_82010 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Gallus gallus"
xref: Reactome:REACT_82448 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Bos taurus"
xref: Reactome:REACT_82560 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_82705 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_83211 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_83233 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_83339 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_83343 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_83521 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Taeniopygia guttata"
xref: Reactome:REACT_83685 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Dictyostelium discoideum"
xref: Reactome:REACT_83929 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Oryza sativa"
xref: Reactome:REACT_84012 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Drosophila melanogaster"
xref: Reactome:REACT_84185 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_84732 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_85076 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_85352 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_86008 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_86054 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Canis familiaris"
xref: Reactome:REACT_86074 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Taeniopygia guttata"
xref: Reactome:REACT_86077 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Gallus gallus"
xref: Reactome:REACT_86330 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mus musculus"
xref: Reactome:REACT_86348 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_87006 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Bos taurus"
xref: Reactome:REACT_87192 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Danio rerio"
xref: Reactome:REACT_87443 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_87448 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_87532 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Bos taurus"
xref: Reactome:REACT_88318 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_88762 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_88921 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Canis familiaris"
xref: Reactome:REACT_89448 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata"
xref: Reactome:REACT_89623 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_89867 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_89919 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_90143 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Mus musculus"
xref: Reactome:REACT_90989 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_91027 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_91170 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Mycobacterium tuberculosis"
xref: Reactome:REACT_91389 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_91693 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Bos taurus"
xref: Reactome:REACT_91746 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Gallus gallus"
xref: Reactome:REACT_91758 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_92399 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_92535 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_92615 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_92737 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_93233 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Danio rerio"
xref: Reactome:REACT_93724 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_93920 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Canis familiaris"
xref: Reactome:REACT_93932 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_94022 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Saccharomyces cerevisiae"
xref: Reactome:REACT_94076 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_94192 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Dictyostelium discoideum"
xref: Reactome:REACT_94248 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_94489 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Dictyostelium discoideum"
xref: Reactome:REACT_94548 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Gallus gallus"
xref: Reactome:REACT_95062 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Gallus gallus"
xref: Reactome:REACT_95378 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA, Xenopus tropicalis"
xref: Reactome:REACT_95512 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Xenopus tropicalis"
xref: Reactome:REACT_95608 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_95831 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Oryza sativa"
xref: Reactome:REACT_95994 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_96433 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Taeniopygia guttata"
xref: Reactome:REACT_96601 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Arabidopsis thaliana"
xref: Reactome:REACT_96805 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Mus musculus"
xref: Reactome:REACT_96911 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_97617 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_97730 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Arabidopsis thaliana"
xref: Reactome:REACT_97950 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Bos taurus"
xref: Reactome:REACT_98096 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA, Gallus gallus"
xref: Reactome:REACT_98191 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Rattus norvegicus"
xref: Reactome:REACT_98235 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_98465 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Oryza sativa"
xref: Reactome:REACT_98828 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+, Rattus norvegicus"
xref: Reactome:REACT_98881 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_98895 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Xenopus tropicalis"
xref: Reactome:REACT_99003 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H, Sus scrofa"
xref: Reactome:REACT_99129 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H, Xenopus tropicalis"
xref: Reactome:REACT_99158 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H, Caenorhabditis elegans"
xref: Reactome:REACT_99256 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Drosophila melanogaster"
xref: Reactome:REACT_99335 "3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+, Taeniopygia guttata"
xref: Reactome:REACT_99549 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H, Mus musculus"
xref: Reactome:REACT_9967 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA, Homo sapiens"
xref: Reactome:REACT_99725 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+, Danio rerio"
xref: Reactome:REACT_99776 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA, Bos taurus"
xref: RHEA:22435
xref: UM-BBD_enzymeID:e0664
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003858
name: 3-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20524]
subset: gosubset_prok
synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30]
xref: EC:1.1.1.30
xref: KEGG:R01361
xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:REACT_100598 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Taeniopygia guttata"
xref: Reactome:REACT_100701 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Gallus gallus"
xref: Reactome:REACT_101716 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Escherichia coli"
xref: Reactome:REACT_103885 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Canis familiaris"
xref: Reactome:REACT_104408 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Sus scrofa"
xref: Reactome:REACT_108608 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Danio rerio"
xref: Reactome:REACT_110558 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Taeniopygia guttata"
xref: Reactome:REACT_1493 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Homo sapiens"
xref: Reactome:REACT_31121 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Bos taurus"
xref: Reactome:REACT_31745 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Mus musculus"
xref: Reactome:REACT_32814 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Rattus norvegicus"
xref: Reactome:REACT_631 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Homo sapiens"
xref: Reactome:REACT_81074 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Mus musculus"
xref: Reactome:REACT_84906 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Sus scrofa"
xref: Reactome:REACT_85059 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Xenopus tropicalis"
xref: Reactome:REACT_87253 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Bos taurus"
xref: Reactome:REACT_87733 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Gallus gallus"
xref: Reactome:REACT_89789 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+, Escherichia coli"
xref: Reactome:REACT_90360 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Xenopus tropicalis"
xref: Reactome:REACT_91670 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Rattus norvegicus"
xref: Reactome:REACT_95508 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Canis familiaris"
xref: Reactome:REACT_97547 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+, Danio rerio"
xref: RHEA:20524
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003859
name: 3-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17852]
subset: gosubset_prok
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55]
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55]
synonym: "crotonase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55]
xref: EC:4.2.1.55
xref: KEGG:R03027
xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
xref: RHEA:17852
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003860
name: 3-hydroxyisobutyryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4]
subset: gosubset_prok
synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4]
xref: EC:3.1.2.4
xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
xref: Reactome:REACT_101449 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Canis familiaris"
xref: Reactome:REACT_102854 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Bos taurus"
xref: Reactome:REACT_104494 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mus musculus"
xref: Reactome:REACT_106977 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Gallus gallus"
xref: Reactome:REACT_107222 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Drosophila melanogaster"
xref: Reactome:REACT_111014 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Taeniopygia guttata"
xref: Reactome:REACT_115031 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Arabidopsis thaliana"
xref: Reactome:REACT_29772 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Saccharomyces cerevisiae"
xref: Reactome:REACT_34277 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Plasmodium falciparum"
xref: Reactome:REACT_77522 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Oryza sativa"
xref: Reactome:REACT_78256 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Dictyostelium discoideum"
xref: Reactome:REACT_83318 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Schizosaccharomyces pombe"
xref: Reactome:REACT_919 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Homo sapiens"
xref: Reactome:REACT_92394 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Caenorhabditis elegans"
xref: Reactome:REACT_93703 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Danio rerio"
xref: Reactome:REACT_95071 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Mycobacterium tuberculosis"
xref: Reactome:REACT_96788 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Rattus norvegicus"
xref: Reactome:REACT_97387 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Xenopus tropicalis"
xref: Reactome:REACT_99747 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA, Sus scrofa"
xref: RHEA:20891
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0003861
name: 3-isopropylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33]
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33]
synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
xref: EC:4.2.1.33
xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003862
name: 3-isopropylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85]
synonym: "IMDH activity" EXACT [EC:1.1.1.85]
synonym: "IPMDH" RELATED [EC:1.1.1.85]
synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
xref: EC:1.1.1.85
xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN
xref: RHEA:25082
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003863
name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]
subset: gosubset_prok
synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4]
synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "BCKDH activity" RELATED [EC:1.2.4.4]
synonym: "BCOAD activity" RELATED [EC:1.2.4.4]
synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4]
synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4]
xref: EC:1.2.4.4
xref: MetaCyc:1.2.4.4-RXN
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0003864
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11]
subset: gosubset_prok
synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
xref: EC:2.1.2.11
xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
xref: RHEA:11827
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0003865
name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5]
synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5]
xref: EC:1.3.99.5
xref: MetaCyc:1.3.99.5-RXN
xref: Reactome:REACT_22210 "Testosterone is converted to 5-alpha-dihydroxytestosterone, Homo sapiens"
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003866
name: 3-phosphoshikimate 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21259]
subset: gosubset_prok
synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19]
synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19]
xref: EC:2.5.1.19
xref: KEGG:R03460
xref: MetaCyc:2.5.1.19-RXN
xref: Reactome:REACT_27315 "EPSP from shikimate 3-phosphate, Mycobacterium tuberculosis"
xref: RHEA:21259
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003867
name: 4-aminobutyrate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]
subset: gosubset_prok
synonym: "4-aminobutanoate transaminase activity" EXACT []
synonym: "4-aminobutyrate aminotransferase activity" EXACT []
synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19]
synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6